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https://www.readbyqxmd.com/read/28304380/comprehensive-analysis-of-the-cancer-genome-atlas-reveals-a-unique-gene-and-non-coding-rna-signature-of-fibrolamellar-carcinoma
#1
Timothy A Dinh, Eva C M Vitucci, Eliane Wauthier, Rondell P Graham, Wendy A Pitman, Tsunekazu Oikawa, Mengjie Chen, Grace O Silva, Kevin G Greene, Michael S Torbenson, Lola M Reid, Praveen Sethupathy
Fibrolamellar carcinoma (FLC) is a unique liver cancer primarily affecting young adults and characterized by a fusion event between DNAJB1 and PRKACA. By analyzing RNA-sequencing data from The Cancer Genome Atlas (TCGA) for >9,100 tumors across ~30 cancer types, we show that the DNAJB1-PRKACA fusion is specific to FLCs. We demonstrate that FLC tumors (n = 6) exhibit distinct messenger RNA (mRNA) and long intergenic non-coding RNA (lincRNA) profiles compared to hepatocellular carcinoma (n = 263) and cholangiocarcinoma (n = 36), the two most common liver cancers...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28298193/identification-of-two-novel-mutations-in-the-slc45a2-gene-in-a-hungarian-pedigree-affected-by-unusual-oca-type-4
#2
Lola Tóth, Beáta Fábos, Katalin Farkas, Adrienn Sulák, Kornélia Tripolszki, Márta Széll, Nikoletta Nagy
BACKGROUND: Oculocutaneous albinism (OCA) is a clinically and genetically heterogenic group of pigmentation abnormalities. OCA type IV (OCA4, OMIM 606574) develops due to homozygous or compound heterozygous mutations in the solute carrier family 45, member 2 (SLC45A2) gene. This gene encodes a membrane-associated transport protein, which regulates tyrosinase activity and, thus, melanin content by changing melanosomal pH and disrupting the incorporation of copper into tyrosinase. METHODS: Here we report two Hungarian siblings affected by an unusual OCA4 phenotype...
March 15, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28289806/estrogenic-effects-in-feral-male-common-carp-cyprinus-carpio-from-laguna-de-bay-philippines
#3
Michelle Grace V Paraso, Justinne Kaye C Morales, Angelo A Clavecillas, Ma Suzanneth Epifania G Lola
This study was conducted to measure 17β-estradiol (E2) levels in Laguna de Bay, Philippines and to examine feral male common carp for evidence of exposure to estrogenic pollutants. Analysis of water samples revealed E2 concentrations of 630 and 550 ng/L from the east and west bay of the lake, respectively. Plasma vitellogenin (VTG) in captured fish ranged from 506 to 4083 ng/mL. In comparison to the reference and west bay groups, fish from the east bay had higher plasma VTG concentrations and reduced gonadosomatic index (GSI)...
March 13, 2017: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28250505/strengthening-health-systems-through-embedded-research
#4
EDITORIAL
Abdul Ghaffar, Etienne V Langlois, Kumanan Rasanathan, Stefan Peterson, Lola Adedokun, Nhan T Tran
No abstract text is available yet for this article.
February 1, 2017: Bulletin of the World Health Organization
https://www.readbyqxmd.com/read/28239548/ictal-laughter-and-crying-should-they-be-classified-as-automatisms
#5
Anna-Marieta Moise, Linda Leary, Lola C Morgan, Alex M Papanastassiou, C Ákos Szabó
Gelastic seizures (GS) describe ictal laughter and are associated with hypothalamic lesions, as well as other cortical areas. Dacrystic seizures (DS), characterized by ictal crying, also have been reported in hypothalamic lesions and focal epilepsy. We describe a young girl with drug resistant focal dyscognitive seizures associated with gelastic and dacrystic features. However, neither laughter nor crying was correlated with a stereotyped electroencephalographic (EEG) pattern or involvement of a particular brain region...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28237252/effect-of-ebola-virus-disease-on-maternal-and-child-health-services-in-guinea-a-retrospective-observational-cohort-study
#6
Alexandre Delamou, Alison M El Ayadi, Sidikiba Sidibe, Therese Delvaux, Bienvenu S Camara, Sah D Sandouno, Abdoul H Beavogui, Georges W Rutherford, Junko Okumura, Wei-Hong Zhang, Vincent De Brouwere
BACKGROUND: The 2014 west African epidemic of Ebola virus disease posed a major threat to the health systems of the countries affected. We sought to quantify the consequences of Ebola virus disease on maternal and child health services in the highly-affected Forest region of Guinea. METHODS: We did a retrospective, observational cohort study of women and children attending public health facilities for antenatal care, institutional delivery, and immunisation services in six of seven health districts in the Forest region (Beyla, Guéckédou, Kissidougou, Lola, Macenta, and N'Zérékoré)...
April 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28228369/feasibility-of-implementing-a-patient-centered-postoperative-wound-monitoring-program-using-smartphone-images-a-pilot-protocol
#7
Sara Fernandes-Taylor, Rebecca L Gunter, Kyla M Bennett, Lola Awoyinka, Shahrose Rahman, Caprice C Greenberg, K Craig Kent
BACKGROUND: Surgical site infections (SSI) represent a significant public health problem as the most common nosocomial infection and a leading cause of unplanned hospital readmissions among surgical patients. Many develop following hospital discharge and often go unrecognized by patients. Telemedicine offers the opportunity to leverage the mobile technology to remotely monitor wound recovery in the transitional period between hospital discharge and routine clinic follow-up. However, many existing telemedicine platforms are episodic, replacing routine follow-up, rather than equipped for continued monitoring; they include only low-risk patient populations and those who already have access to and comfort with the necessary technology; and transmit no visual information...
February 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28196751/-hospital-emergencies-arising-from-nursing-homes-in-a-region-evolution-characteristics-and-appropriateness
#8
Inma Sánchez-Pérez, Nuri Comes Garcia, Lola Romero Piniella, Gemma Prats Martos, Gemma Arnau Bataller, Jordi Coderch
OBJECTIVE: Hospital emergencies (HE) arising from nursing homes (NH) are on the rise. We analyse the evolution, characteristics and appropriateness of HE of NH residents in a region, as well as resulting hospital admissions. METHOD: Retrospective descriptive study between 2010 and 2013 of institutionalised residents of 11 NH located in Baix Empordà (704 beds) and Palamós Hospital. VARIABLES: Gender, age, morbidity and relative weight according to clinical risk groups (CRG), NH, length of stay, diagnosis of the emergency, appropriateness of HE according to Bermejo's criteria and the HE appropriateness protocol (HEAP), and appropriateness of hospitalisations according to the Appropriateness Evaluation Protocol (AEP)...
February 10, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28156105/a-quantum-mechanical-study-of-the-k-j-and-k-j-vector-correlations-for-the-h-lih-%C3%A2-li-h2-reaction
#9
Ahmad W Huran, L González-Sánchez, S Gomez-Carrasco, J Aldegunde
We have characterized the stereodynamics of the H + LiH (v = 0, j = 0-1) reactive collisions leading to H2 formation through the quantum mechanical analysis of the k-j and k'-j' vector correlations that describe the polarization of the reactants and products, respectively. Our results, which cover the collision energy interval between 10(-4) and 1 eV, are unexpectedly complex given the apparent simplicity and featureless nature of the potential energy surface for the LiH2 system and point toward the existence of a dynamical barrier connected to the centrifugal barrier...
February 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28156050/evaluation-of-a-decision-support-strategy-for-the-control-of-powdery-mildew-erysiphe-necator-schw-burr-in-grapevine-in-the-central-region-of-chile
#10
Héctor Valdés-Gómez, Miguel Araya-Alman, Carolina Pañitrur-De la Fuente, Nicolás Verdugo-Vásquez, Mauricio Lolas, César Acevedo-Opazo, Christian Gary, Agnès Calonnec
BACKGROUND: The primary strategy to control powdery mildew in Chilean vineyards involves periodic fungicide spraying, which may lead to many environmental and human health risks. This study aimed to implement and evaluate the effectiveness and economic feasibility of a novel Decision Support Strategy (DSS) to limit the number of treatments against this pathogen. An experiment was conducted between the 2010 and 2013 seasons in two irrigated vine fields, one containing a cultivar of Cabernet Sauvignon (CS) and another of Chardonnay (CH)...
February 3, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28150755/ecology-vast-peatlands-found-in-the-congo-basin
#11
Lola Fatoyinbo
No abstract text is available yet for this article.
February 1, 2017: Nature
https://www.readbyqxmd.com/read/28121968/outcomes-of-the-suture-pull-through-technique-for-repair-of-lateral-skull-base-csf-fistula-and-encephaloceles
#12
Brendan P O'Connell, Jacob B Hunter, Alex D Sweeney, Reid C Thompson, Lola B Chambless, George B Wanna, Alejandro Rivas
OBJECTIVE: Describe the safety profile and surgical outcomes of a combined transmastoid-middle cranial fossa suture "pull-through" technique for repair of lateral skull base defects. STUDY DESIGN: Retrospective. SETTING: Tertiary care hospital. PATIENTS: Patients undergoing surgery for cerebrospinal fluid (CSF) fistula and/or encephalocele. INTERVENTION: Combined transmastoid and middle fossa approach using suture pull-through technique...
March 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28108553/the-bright-fluorescent-protein-mneongreen-facilitates-protein-expression-analysis-in-vivo
#13
Lola Hostettler, Laura Grundy, Stéphanie Käser-Pébernard, Chantal Wicky, William R Schafer, Dominique A Glauser
The Green Fluorescent Protein (GFP) has been tremendously useful to investigate cell architecture, protein localization, and protein function. While recent developments in transgenesis and genome editing methods enable working with few transgene copies and, consequently, with physiological expression levels, lower signal intensity might become a limiting factor. The recently developed mNeonGreen protein is a brighter alternative to GFP in vitro The goal of the present study was to determine how mNeonGreen performs in vivo in Caenorhabditis elegans, a model extensively used for fluorescence imaging in intact animals...
January 20, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28074322/decreased-survival-in-glioblastomas-is-specific-to-contact-with-the-ventricular-subventricular-zone-not-subgranular-zone-or-corpus-callosum
#14
Akshitkumar M Mistry, Michael C Dewan, Gabrielle A White-Dzuro, Philip R Brinson, Kyle D Weaver, Reid C Thompson, Rebecca A Ihrie, Lola B Chambless
The clinical effect of radiographic contact of glioblastoma (GBM) with neurogenic zones (NZ)-the ventricular-subventricular (VSVZ) and subgranular (SGZ) zones-and the corpus callosum (CC) remains unclear and, in the case of the SGZ, unexplored. We investigated (1) if GBM contact with a NZ correlates with decreased survival; (2) if so, whether this effect is associated with a specific NZ; and (3) if radiographic contact with or invasion of the CC by GBM is associated with decreased survival. We retrospectively identified 207 adult patients who underwent cytoreductive surgery for GBM followed by chemotherapy and/or radiation...
January 10, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28018120/hedonic-quality-or-reward-a-study-of-basic-pleasure-in-homeostasis-and-decision-making-of-a-motivated-autonomous-robot
#15
Matthew Lewis, Lola Cañamero
We present a robot architecture and experiments to investigate some of the roles that pleasure plays in the decision making (action selection) process of an autonomous robot that must survive in its environment. We have conducted three sets of experiments to assess the effect of different types of pleasure-related versus unrelated to the satisfaction of physiological needs-under different environmental circumstances. Our results indicate that pleasure, including pleasure unrelated to need satisfaction, has value for homeostatic management in terms of improved viability and increased flexibility in adaptive behavior...
October 2016: Adaptive Behavior
https://www.readbyqxmd.com/read/28000941/cost-analysis-of-laparoscopic-lavage-compared-with-sigmoid-resection-for-perforated-diverticulitis-in-the-ladies-trial
#16
S Vennix, S van Dieren, B C Opmeer, J F Lange, W A Bemelman
BACKGROUND: Laparoscopic peritoneal lavage is an alternative to sigmoid resection in selected patients presenting with purulent peritonitis from perforated diverticulitis. Although recent trials have lacked superiority for lavage in terms of morbidity, mortality was not compromised, and beneficial secondary outcomes were shown. These included shorter duration of surgery, less stoma formation and less surgical reintervention (including stoma reversal) for laparoscopic lavage versus sigmoid resection respectively...
January 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/27992493/clinical-and-metabolic-characteristics-among-mexican-children-with-different-types-of-diabetes-mellitus
#17
María Lola Evia-Viscarra, Rodolfo Guardado-Mendoza, Edel Rafael Rodea-Montero
BACKGROUND: Current classification of diabetes mellitus (DM) is based on etiology and includes type 1 (T1DM), type 2 (T2DM), gestational, and other. Clinical and pathophysiological characteristics of T1DM and T2DM in the same patient have been designated as type 1.5 DM (T1.5DM). OBJECTIVES: The aim of this study was to classify pediatric patients with DM based on pancreatic autoimmunity and the presence or absence of overweight/obesity, and to compare the clinical, anthropometric, and biochemical characteristics between children in the different classes of DM...
2016: PloS One
https://www.readbyqxmd.com/read/27925665/viral-oncoprotein-antibodies-as-a-marker-for-recurrence-of-merkel-cell-carcinoma-a-prospective-validation-study
#18
Kelly G Paulson, Christopher W Lewis, Mary W Redman, William T Simonson, Aaron Lisberg, Deborah Ritter, Chihiro Morishima, Kathleen Hutchinson, Lola Mudgistratova, Astrid Blom, Jayasri Iyer, Ata S Moshiri, Erica S Tarabadkar, Joseph J Carter, Shailender Bhatia, Masaoki Kawasumi, Denise A Galloway, Mark H Wener, Paul Nghiem
BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive skin cancer with a recurrence rate of >40%. Of the 2000 MCC cases per year in the United States, most are caused by the Merkel cell polyomavirus (MCPyV). Antibodies to MCPyV oncoprotein (T-antigens) have been correlated with MCC tumor burden. The present study assesses the clinical utility of MCPyV-oncoprotein antibody titers for MCC prognostication and surveillance. METHODS: MCPyV-oncoprotein antibody detection was optimized in a clinical laboratory...
December 7, 2016: Cancer
https://www.readbyqxmd.com/read/27911441/sirt1-protects-the-heart-from-er-stress-induced-cell-death-through-eif2%C3%AE-deacetylation
#19
Alexandre Prola, Julie Pires Da Silva, Arnaud Guilbert, Lola Lecru, Jérôme Piquereau, Maxance Ribeiro, Philippe Mateo, Mélanie Gressette, Dominique Fortin, Céline Boursier, Cindy Gallerne, Anaïs Caillard, Jane-Lise Samuel, Hélène François, David A Sinclair, Pierre Eid, Renée Ventura-Clapier, Anne Garnier, Christophe Lemaire
Over the past decade, endoplasmic reticulum (ER) stress has emerged as an important mechanism involved in the pathogenesis of cardiovascular diseases including heart failure. Cardiac therapy based on ER stress modulation is viewed as a promising avenue toward effective therapies for the diseased heart. Here, we tested whether sirtuin-1 (SIRT1), a NAD(+)-dependent deacetylase, participates in modulating ER stress response in the heart. Using cardiomyocytes and adult-inducible SIRT1 knockout mice, we demonstrate that SIRT1 inhibition or deficiency increases ER stress-induced cardiac injury, whereas activation of SIRT1 by the SIRT1-activating compound STAC-3 is protective...
February 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27898696/regulation-of-gonad-morphogenesis-in-drosophila-melanogaster-by-btb-family-transcription-factors
#20
Diane Silva, Kenneth W Olsen, Magdalena N Bednarz, Andrew Droste, Christopher P Lenkeit, Edwin Chaharbakhshi, Emily R Temple-Wood, Jennifer C Jemc
During embryogenesis, primordial germ cells (PGCs) and somatic gonadal precursor cells (SGPs) migrate and coalesce to form the early gonad. A failure of the PGCs and SGPs to form a gonad with the proper architecture not only affects germ cell development, but can also lead to infertility. Therefore, it is critical to identify the molecular mechanisms that function within both the PGCs and SGPs to promote gonad morphogenesis. We have characterized the phenotypes of two genes, longitudinals lacking (lola) and ribbon (rib), that are required for the coalescence and compaction of the embryonic gonad in Drosophila melanogaster...
2016: PloS One
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