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https://www.readbyqxmd.com/read/28196751/-hospital-emergencies-arising-from-nursing-homes-in-a-region-evolution-characteristics-and-appropriateness
#1
Inma Sánchez-Pérez, Nuri Comes Garcia, Lola Romero Piniella, Gemma Prats Martos, Gemma Arnau Bataller, Jordi Coderch
OBJECTIVE: Hospital emergencies (HE) arising from nursing homes (NH) are on the rise. We analyse the evolution, characteristics and appropriateness of HE of NH residents in a region, as well as resulting hospital admissions. METHOD: Retrospective descriptive study between 2010 and 2013 of institutionalised residents of 11 NH located in Baix Empordà (704 beds) and Palamós Hospital. VARIABLES: Gender, age, morbidity and relative weight according to clinical risk groups (CRG), NH, length of stay, diagnosis of the emergency, appropriateness of HE according to Bermejo's criteria and the HE appropriateness protocol (HEAP), and appropriateness of hospitalisations according to the Appropriateness Evaluation Protocol (AEP)...
February 10, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28156105/a-quantum-mechanical-study-of-the-k-j-and-k-j-vector-correlations-for-the-h-lih-%C3%A2-li-h2-reaction
#2
Ahmad W Huran, L González-Sánchez, S Gomez-Carrasco, J Aldegunde
We have characterized the stereodynamics of the H + LiH (v = 0, j = 0-1) reactive collisions leading to H2 formation through the quantum mechanical analysis of the k-j and k'-j' vector correlations that describe the polarization of the reactants and products, respectively. Our results, which cover the collision energy interval between 10(-4) and 1 eV, are unexpectedly complex given the apparent simplicity and featureless nature of the potential energy surface for the LiH2 system and point toward the existence of a dynamical barrier connected to the centrifugal barrier...
February 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28156050/evaluation-of-a-decision-support-strategy-for-the-control-of-powdery-mildew-erysiphe-necator-schw-burr-in-grapevine-in-the-central-region-of-chile
#3
Héctor Valdés-Gómez, Miguel Araya-Alman, Carolina Pañitrur-De la Fuente, Nicolás Verdugo-Vásquez, Mauricio Lolas, César Acevedo-Opazo, Christian Gary, Agnès Calonnec
BACKGROUND: The primary strategy to control powdery mildew in Chilean vineyards involves periodic fungicide spraying, which may lead to many environmental and human health risks. This study aimed to implement and evaluate the effectiveness and economic feasibility of a novel Decision Support Strategy (DSS) to limit the number of treatments against this pathogen. An experiment was conducted between the 2010 and 2013 seasons in two irrigated vine fields, one containing a cultivar of Cabernet Sauvignon (CS) and another of Chardonnay (CH)...
February 3, 2017: Pest Management Science
https://www.readbyqxmd.com/read/28150755/ecology-vast-peatlands-found-in-the-congo-basin
#4
Lola Fatoyinbo
No abstract text is available yet for this article.
February 1, 2017: Nature
https://www.readbyqxmd.com/read/28121968/outcomes-of-the-suture-pull-through-technique-for-repair-of-lateral-skull-base-csf-fistula-and-encephaloceles
#5
Brendan P O'Connell, Jacob B Hunter, Alex D Sweeney, Reid C Thompson, Lola B Chambless, George B Wanna, Alejandro Rivas
OBJECTIVE: Describe the safety profile and surgical outcomes of a combined transmastoid-middle cranial fossa suture "pull-through" technique for repair of lateral skull base defects. STUDY DESIGN: Retrospective. SETTING: Tertiary care hospital. PATIENTS: Patients undergoing surgery for cerebrospinal fluid (CSF) fistula and/or encephalocele. INTERVENTION: Combined transmastoid and middle fossa approach using suture pull-through technique...
March 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28108553/the-bright-fluorescent-protein-mneongreen-facilitates-protein-expression-analysis-in-vivo
#6
Lola Hostettler, Laura Grundy, Stéphanie Käser-Pébernard, Chantal Wicky, William R Schafer, Dominique A Glauser
The Green Fluorescent Protein (GFP) has been tremendously useful to investigate cell architecture, protein localization, and protein function. While recent developments in transgenesis and genome editing methods enable working with few transgene copies and, consequently, with physiological expression levels, lower signal intensity might become a limiting factor. The recently developed mNeonGreen protein is a brighter alternative to GFP in vitro The goal of the present study was to determine how mNeonGreen performs in vivo in Caenorhabditis elegans, a model extensively used for fluorescence imaging in intact animals...
January 20, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28074322/decreased-survival-in-glioblastomas-is-specific-to-contact-with-the-ventricular-subventricular-zone-not-subgranular-zone-or-corpus-callosum
#7
Akshitkumar M Mistry, Michael C Dewan, Gabrielle A White-Dzuro, Philip R Brinson, Kyle D Weaver, Reid C Thompson, Rebecca A Ihrie, Lola B Chambless
The clinical effect of radiographic contact of glioblastoma (GBM) with neurogenic zones (NZ)-the ventricular-subventricular (VSVZ) and subgranular (SGZ) zones-and the corpus callosum (CC) remains unclear and, in the case of the SGZ, unexplored. We investigated (1) if GBM contact with a NZ correlates with decreased survival; (2) if so, whether this effect is associated with a specific NZ; and (3) if radiographic contact with or invasion of the CC by GBM is associated with decreased survival. We retrospectively identified 207 adult patients who underwent cytoreductive surgery for GBM followed by chemotherapy and/or radiation...
January 10, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28018120/hedonic-quality-or-reward-a-study-of-basic-pleasure-in-homeostasis-and-decision-making-of-a-motivated-autonomous-robot
#8
Matthew Lewis, Lola Cañamero
We present a robot architecture and experiments to investigate some of the roles that pleasure plays in the decision making (action selection) process of an autonomous robot that must survive in its environment. We have conducted three sets of experiments to assess the effect of different types of pleasure-related versus unrelated to the satisfaction of physiological needs-under different environmental circumstances. Our results indicate that pleasure, including pleasure unrelated to need satisfaction, has value for homeostatic management in terms of improved viability and increased flexibility in adaptive behavior...
October 2016: Adaptive Behavior
https://www.readbyqxmd.com/read/28000941/cost-analysis-of-laparoscopic-lavage-compared-with-sigmoid-resection-for-perforated-diverticulitis-in-the-ladies-trial
#9
S Vennix, S van Dieren, B C Opmeer, J F Lange, W A Bemelman
BACKGROUND: Laparoscopic peritoneal lavage is an alternative to sigmoid resection in selected patients presenting with purulent peritonitis from perforated diverticulitis. Although recent trials have lacked superiority for lavage in terms of morbidity, mortality was not compromised, and beneficial secondary outcomes were shown. These included shorter duration of surgery, less stoma formation and less surgical reintervention (including stoma reversal) for laparoscopic lavage versus sigmoid resection respectively...
January 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/27992493/clinical-and-metabolic-characteristics-among-mexican-children-with-different-types-of-diabetes-mellitus
#10
María Lola Evia-Viscarra, Rodolfo Guardado-Mendoza, Edel Rafael Rodea-Montero
BACKGROUND: Current classification of diabetes mellitus (DM) is based on etiology and includes type 1 (T1DM), type 2 (T2DM), gestational, and other. Clinical and pathophysiological characteristics of T1DM and T2DM in the same patient have been designated as type 1.5 DM (T1.5DM). OBJECTIVES: The aim of this study was to classify pediatric patients with DM based on pancreatic autoimmunity and the presence or absence of overweight/obesity, and to compare the clinical, anthropometric, and biochemical characteristics between children in the different classes of DM...
2016: PloS One
https://www.readbyqxmd.com/read/27925665/viral-oncoprotein-antibodies-as-a-marker-for-recurrence-of-merkel-cell-carcinoma-a-prospective-validation-study
#11
Kelly G Paulson, Christopher W Lewis, Mary W Redman, William T Simonson, Aaron Lisberg, Deborah Ritter, Chihiro Morishima, Kathleen Hutchinson, Lola Mudgistratova, Astrid Blom, Jayasri Iyer, Ata S Moshiri, Erica S Tarabadkar, Joseph J Carter, Shailender Bhatia, Masaoki Kawasumi, Denise A Galloway, Mark H Wener, Paul Nghiem
BACKGROUND: Merkel cell carcinoma (MCC) is an aggressive skin cancer with a recurrence rate of >40%. Of the 2000 MCC cases per year in the United States, most are caused by the Merkel cell polyomavirus (MCPyV). Antibodies to MCPyV oncoprotein (T-antigens) have been correlated with MCC tumor burden. The present study assesses the clinical utility of MCPyV-oncoprotein antibody titers for MCC prognostication and surveillance. METHODS: MCPyV-oncoprotein antibody detection was optimized in a clinical laboratory...
December 7, 2016: Cancer
https://www.readbyqxmd.com/read/27911441/sirt1-protects-the-heart-from-er-stress-induced-cell-death-through-eif2%C3%AE-deacetylation
#12
Alexandre Prola, Julie Pires Da Silva, Arnaud Guilbert, Lola Lecru, Jérôme Piquereau, Maxance Ribeiro, Philippe Mateo, Mélanie Gressette, Dominique Fortin, Céline Boursier, Cindy Gallerne, Anaïs Caillard, Jane-Lise Samuel, Hélène François, David A Sinclair, Pierre Eid, Renée Ventura-Clapier, Anne Garnier, Christophe Lemaire
Over the past decade, endoplasmic reticulum (ER) stress has emerged as an important mechanism involved in the pathogenesis of cardiovascular diseases including heart failure. Cardiac therapy based on ER stress modulation is viewed as a promising avenue toward effective therapies for the diseased heart. Here, we tested whether sirtuin-1 (SIRT1), a NAD(+)-dependent deacetylase, participates in modulating ER stress response in the heart. Using cardiomyocytes and adult-inducible SIRT1 knockout mice, we demonstrate that SIRT1 inhibition or deficiency increases ER stress-induced cardiac injury, whereas activation of SIRT1 by the SIRT1-activating compound STAC-3 is protective...
February 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/27898696/regulation-of-gonad-morphogenesis-in-drosophila-melanogaster-by-btb-family-transcription-factors
#13
Diane Silva, Kenneth W Olsen, Magdalena N Bednarz, Andrew Droste, Christopher P Lenkeit, Edwin Chaharbakhshi, Emily R Temple-Wood, Jennifer C Jemc
During embryogenesis, primordial germ cells (PGCs) and somatic gonadal precursor cells (SGPs) migrate and coalesce to form the early gonad. A failure of the PGCs and SGPs to form a gonad with the proper architecture not only affects germ cell development, but can also lead to infertility. Therefore, it is critical to identify the molecular mechanisms that function within both the PGCs and SGPs to promote gonad morphogenesis. We have characterized the phenotypes of two genes, longitudinals lacking (lola) and ribbon (rib), that are required for the coalescence and compaction of the embryonic gonad in Drosophila melanogaster...
2016: PloS One
https://www.readbyqxmd.com/read/27898569/elimination-of-mother-to-child-transmission-of-syphilis-in-the-americas-a-goal-that-must-not-slip-away
#14
Lola V Stamm, Angel A Noda
No abstract text is available yet for this article.
January 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/27893352/prevalence-of-antibodies-to-a-new-histo-blood-system-the-fors-system
#15
Carlos Jesus, Camilla Hesse, Clara Rocha, Nádia Osório, Ana Valado, Armando Caseiro, António Gabriel, Lola Svensson, Ali-Reza Moslemi, Wafa Abu Siba, Mahmoud A Srour, Cristina Pereira, Jorge Tomaz, Paulo Teixeira, Fernando Mendes
BACKGROUND: In 1987, three unrelated English families were reported with a putative blood subgroup called Apae. Swedish researchers later found evidence leading to abolishment of the Apae subgroup and establishment instead of the FORS blood group system (System 31 - ISBT, 2012). It is important to know the prevalence of antibodies in order to make the best decisions in transfusion medicine. Cells expressing the Forssman saccharide, such as sheep erythrocytes, are needed to detect the anti-Forssman antibody...
October 24, 2016: Blood Transfusion, Trasfusione del Sangue
https://www.readbyqxmd.com/read/27885144/treatment-of-multiple-myeloma-in-a-heart-transplant-recipient-focus-on-the-immunomodulatory-effects-of-lenalidomide
#16
Lola Xie, Bartosz Jozwik, Phillip Weeks, L Maximilian Buja, Robert Brown, Sriram Nathan, Keshava Rajagopal, Christina Paruthi, Biswajit Kar, Pranav Loyalka, Indranee Rajapreyar
Malignancy following solid organ transplant remains a significant threat to the survival of cardiac transplant recipients. Plasma cell dyscrasias including multiple myeloma have been encountered in this population, and medication treatments traditionally used to treat these disorders demonstrate immunomodulatory effects that may have implications on the transplanted allograft. Lenalidomide is an immunomodulatory agent that has been used to treat plasma cell disorders, including light-chain amyloidosis (AL) and multiple myeloma, and represents such a class of medications in which the risks and benefits in the solid organ transplant population remain to be fully elucidated...
November 24, 2016: Progress in Transplantation
https://www.readbyqxmd.com/read/27862050/impact-of-individual-and-neighborhood-factors-on-cardiovascular-risk-in-white-hispanic-and-non-hispanic-women-and-men
#17
Tanya Cohn, Arlene Miller, Louis Fogg, Lynne T Braun, Lola Coke
Cardiovascular disease (CVD) is the leading cause of mortality for adults in the US, regardless of ethnicity. A cross-sectional correlational design was used to describe and compare CVD risk and cardiac mortality in White Hispanic and non-Hispanic women and men. Data from 3,317 individuals (1,523 women and 1,794 men) hospitalized for non-cardiac causes during 2012-2013, and data from the 2010 United States Census were included. The sex-specific 10-year Framingham General Cardiovascular Risk Score (FRS-10) was used to estimate long-term risk for major cardiac events...
November 16, 2016: Research in Nursing & Health
https://www.readbyqxmd.com/read/27842569/efficacy-and-safety-of-psychostimulants-for-amphetamine-and-methamphetamine-use-disorders-a-systematic-review-and-meta-analysis
#18
Meha Bhatt, Laura Zielinski, Lola Baker-Beal, Neera Bhatnagar, Natalia Mouravska, Phillip Laplante, Andrew Worster, Lehana Thabane, Zainab Samaan
BACKGROUND: Amphetamine and methamphetamine use disorders are associated with severe health and social consequences. No pharmacological therapy has been approved for the treatment of these disorders. Psychostimulants can act as maintenance-like therapies for managing substance use among these patients. The aim of this study is to evaluate the literature examining the efficacy and safety of psychostimulant agents for increasing abstinence and treatment retention among patients with amphetamine and methamphetamine use disorders...
November 14, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27837008/transcriptional-categorization-of-the-etiology-of-pneumonia-syndrome-in-pediatric-patients-in-malaria-endemic-areas
#19
Jacob Silterra, Michael A Gillette, Miguel Lanaspa, Karell G Pellé, Clarissa Valim, Rushdy Ahmad, Sozinho Acácio, Katherine D Almendinger, Yan Tan, Lola Madrid, Pedro L Alonso, Steven A Carr, Roger C Wiegand, Quique Bassat, Jill P Mesirov, Danny A Milner, Dyann F Wirth
BACKGROUND:  Pediatric acute respiratory distress in tropical settings is very common. Bacterial pneumonia is a major contributor to morbidity and mortality and requires adequate diagnosis for correct treatment. A rapid test that could identify bacterial (vs. other) infections would have great clinical utility. METHODS AND FINDINGS:  We performed RNA-Seq and analyzed the transcriptomes of 68 pediatric patients with well-characterized clinical phenotype to identify transcriptional features associated with each disease class...
November 10, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27833075/a-pilot-study-evaluating-concordance-between-blood-based-and-patient-matched-tumor-molecular-testing-within-pancreatic-cancer-patients-participating-in-the-know-your-tumor-kyt-initiative
#20
Michael J Pishvaian, R Joseph Bender, Lynn M Matrisian, Lola Rahib, Andrew Hendifar, William A Hoos, Sam Mikhail, Vincent Chung, Vincent Picozzi, Craig Heartwell, Kimberly Mason, Katelyn Varieur, Metasebia Aberra, Subha Madhavan, Emanuel Petricoin, Jonathan R Brody
Recent improvements in next-generation sequencing (NGS) technology have enabled detection of biomarkers in cell-free DNA in blood and may ultimately replace invasive tissue biopsies. However, a better understanding of the performance of blood-based NGS assays is needed prior to routine clinical use. As part of an IRB-approved molecular profiling registry trial of pancreatic ductal adenocarcinoma (PDA) patients, we facilitated blood-based NGS testing of 34 patients from multiple community-based and high-volume academic oncology practices...
November 8, 2016: Oncotarget
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