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https://www.readbyqxmd.com/read/28910402/nasopharyngeal-bacterial-load-as-a-marker-for-rapid-and-easy-diagnosis-of-invasive-pneumococcal-disease-in-children-from-mozambique
#1
Pedro Brotons, Quique Bassat, Miguel Lanaspa, Desiree Henares, Amaresh Perez-Arguello, Lola Madrid, Reyes Balcells, Sozinho Acacio, Maria Andres-Franch, Maria Angeles Marcos, Ana Valero-Rello, Carmen Muñoz-Almagro
BACKGROUND: Current diagnostic methods for detection of Streptococcus pneumoniae in children with suspected invasive pneumococcal disease have limitations of accuracy, timeliness, and patient convenience. This study aimed to determine the performance of pneumococcal load quantified with a real-time polymerase-chain reaction in nasopharyngeal samples to diagnose invasive pneumococcal disease in children. METHODS: Matched case-control study of patients <5 years of age with invasive pneumococcal disease admitted to the Manhiça District Hospital (Mozambique) and asymptomatic controls recruited in different periods between 2006 and 2014...
2017: PloS One
https://www.readbyqxmd.com/read/28904172/fda-approval-summary-daratumumab-for-treatment-of-multiple-myeloma-after-one-prior-therapy
#2
Vishal Bhatnagar, Nicole J Gormley, Lola Luo, Yuan Li Shen, Rajeshwari Sridhara, Sriram Subramaniam, Guoxiang Shen, Lian Ma, Stacy Shord, Kirsten B Goldberg, Ann T Farrell, Amy E McKee, Richard Pazdur
On November 21, 2016, the U.S. Food and Drug Administration granted regular approval to daratumumab in combination with lenalidomide and dexamethasone, or bortezomib and dexamethasone, for the treatment of patients with multiple myeloma who have received at least one prior therapy. Approval was based on two randomized, open-label trials in which daratumumab was added to these backbone therapies. The MMY3003 trial demonstrated substantial improvement in progression-free survival (PFS) when daratumumab was added to lenalidomide and dexamethasone compared with lenalidomide and dexamethasone alone...
September 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28903591/negative-self-evaluating-emotions-as-mediator-in-the-relationship-between-childhood-emotional-trauma-and-alexithymia-in-adulthood
#3
Serge Lecours, Frédérick L Philippe, Marie-Ève Boucher, Lola Ahoundova, Catherine Allard-Chapais
No abstract text is available yet for this article.
October 2016: Journal of the American Psychoanalytic Association
https://www.readbyqxmd.com/read/28902512/cloud-processing-of-secondary-organic-aerosol-from-isoprene-and-methacrolein-photooxidation
#4
Chiara Giorio, Anne Monod, Lola Brégonzio-Rozier, Helen Langley DeWitt, Mathieu Cazaunau, Brice Temime-Roussel, Aline Gratien, Vincent Michoud, Edouard Pangui, Sylvain Ravier, Arthur T Zielinski, Andrea Tapparo, Reinhilde Vermeylen, Magda Claeys, Didier Voisin, Markus Kalberer, Jean-Francois Doussin
Aerosol-cloud interaction contributes to the largest uncertainties in the estimation and interpretation of the Earth's changing energy budget. The present study explores experimentally the impacts of water condensation evaporation events, mimicking processes occurring in atmospheric clouds, on the molecular composition of secondary organic aerosol (SOA) from the photooxidation of methacrolein. A range of on- and off-line mass spectrometry techniques were used to obtain a detailed chemical characterization of SOA formed in control experiments in dry conditions, in triphasic experiments, i...
September 13, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28901831/collaboration-between-biomedical-and-complementary-and-alternative-care-providers-barriers-and-pathways
#5
Alberta S J van der Watt, Gareth Nortje, Lola Kola, John Appiah-Poku, Caleb Othieno, Benjamin Harris, Bibilola D Oladeji, Oluyomi Esan, Victor Makanjuola, LeShawndra N Price, Soraya Seedat, Oye Gureje
We examined the scope of collaborative care for persons with mental illness as implemented by traditional healers, faith healers, and biomedical care providers. We conducted semistructured focus group discussions in Ghana, Kenya, and Nigeria with traditional healers, faith healers, biomedical care providers, patients, and their caregivers. Transcribed data were thematically analyzed. A barrier to collaboration was distrust, influenced by factionalism, charlatanism, perceptions of superiority, limited roles, and responsibilities...
September 1, 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28901271/the-role-of-cannabinoid-receptors-in-renal-diseases
#6
Hélène François, Lola Lecru
Chronic kidney disease (CKD) remains a major challenge for Public Health systems and corresponds to the replacement of renal functional tissue by extra-cellular matrix proteins such as collagens and fibronectin. There is no efficient treatment to date for CKD except nephroprotective strategies. The cannabinoid system and more specifically the cannabinoid receptors 1 (CB1) and 2 (CB2) may represent a new therapeutic target in CKD. Our review will first focus on the current state of knowledge regarding the cannabinoid system in normal renal physiology and in various experimental nephropathies, especially diabetes...
September 11, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28900233/copt2-a-plasma-membrane-located-copper-transporter-is-involved-in-the-uptake-of-au-in-arabidopsis
#7
Manish Tiwari, Perumal Venkatachalam, Lola Penarrubia, Shivendra V Sahi
The mechanism of gold nanoparticle formation and genes involved in such processes, especially Au transport in plants are not understood. Previous reports pointed to the probable role of COPT2 in Au transport based on the transcript accumulation of COPT2 under Au exposure. Here, we provide evidence revealing the additional role of COPT2 for Au mobilization in yeast and Arabidopsis. The COPT2 transcripts significantly accumulated in the root of Arabidopsis under Au exposure. The expression of COPT2 restores Cu uptake ability in ctr1Δctr3Δ mutants and leads to Au sensitivity in yeast, which is comparable to Cu in growth kinetics experiments...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28892741/effect-of-diet-with-omega-3-in-basal-brain-electrical-activity-and-during-status-epilepticus-in-rats
#8
Daniella Tavares Pessoa, Eva Luana Almeida da Silva, Edbhergue Ventura Lola Costa, Romildo Albuquerque Nogueira
Western diets are high in saturated fat and low in omega-3. Certain animals cannot produce omega-3 from their own lipids, making it necessary for it to be acquired from the diet. However, omega-3s are important components of the plasma membrane, and altering their proportions can promote physical and chemical alterations in the membranes, which may modify neuronal excitability. These alterations occur in healthy individuals, as well as in patients with epilepsy who are more sensitive to changes in brain electrical activity...
September 1, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/28888603/potential-factors-involved-in-virulence-of-cronobacter-sakazakii-isolates-by-comparative-transcriptome-analysis
#9
Yingwang Ye, Xiyan Zhang, Maofeng Zhang, Na Ling, Haiyan Zeng, Jina Gao, Rui Jiao, Qingping Wu, Jumei Zhang
Cronobacter species are important foodborne pathogens causing severe infections in neonates through consumption of contaminated powdered infant formula. However, the virulence-associated factors in Cronobacter are largely unknown. In this study, the transcriptome analysis between highly virulent Cronobacter sakazakii G362 and attenuated L3101 strains was used to reveal the potential factors involved in virulence. The total transcripts were grouped into 20 clusters of orthologous group categories and summarized in 3 gene ontology categories (biological process, cellular component, and molecular function)...
September 6, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28888414/use-of-silver-diamine-fluoride-for-the-maintenance-of-dental-prostheses-in-a-high-caries-risk-patient-a-medical-management-approach
#10
Lola Giusti, Cathrine Steinborn, Maya Steinborn
A technique for using silver diamine fluoride (SDF) as part of a regimen to help maintain dental prostheses in a patient with scleroderma and at high risk of caries is presented. Medically compromised, xerostomic, or elderly patients generally face greater risk of caries and specifically with prosthetic retainer teeth. SDF is a minimally invasive solution to this problem. A technique is described for using SDF to arrest and prevent new caries with the goal of maintaining fixed and removable prostheses and supporting teeth in a cost-effective manner...
September 6, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28864089/transient-hyperandrogenism-in-2-preterm-twins-with-exposure-to-antiretrovirals
#11
Emilio García García, Lola Falcón-Neyra, Laura Audí
No abstract text is available yet for this article.
August 29, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28843648/5-gene-differential-expression-predicts-stability-of-human-intestinal-allografts
#12
Paloma Talayero, Lola Alonso-Guirado, Guillermo Padilla, Haydee Artaza, Ana Dopazo, Fátima Sánchez-Cabo, Sarbelio Rodríguez-Muñoz, Jorge Calvo-Pulido, Esther Mancebo, Mario García de Lacoba, Estela Paz-Artal
In intestinal allografts, endoscopy and histology detect the injury once changes in the bowel wall architecture have occurred. We aimed to identify a molecular signature that could predict early deterioration, within histologically indistinguishable biopsies with "minimal changes" (MC) pathology. Sixty biopsies from 12 adult recipients were longitudinally taken during 8years post-transplant. They were classified as either stable (STA) or non-stable (NSTA) according to the prospectively recorded number, frequency and severity of rejection events of the allograft...
August 24, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/28837019/medial-thalamic-stroke-and-its-impact-on-familiarity-and-recollection
#13
Lola Danet, Jérémie Pariente, Pierre Eustache, Nicolas Raposo, Igor Sibon, Jean-François Albucher, Fabrice Bonneville, Patrice Péran, Emmanuel J Barbeau
Models of recognition memory have postulated that the mammillo-thalamic tract (MTT)/anterior thalamic nucleus (AN) complex would be critical for recollection while the Mediodorsal nucleus (MD) of the thalamus would support familiarity and indirectly also be involved in recollection (Aggleton et al., 2011). 12 patients with left thalamic stroke underwent a neuropsychological assessment, three verbal recognition memory tasks assessing familiarity and recollection each using different procedures and a high-resolution structural MRI...
August 24, 2017: ELife
https://www.readbyqxmd.com/read/28827613/biogeographic-distributions-of-neotropical-trees-reflect-their-directly-measured-drought-tolerances
#14
Adriane Esquivel-Muelbert, David Galbraith, Kyle G Dexter, Timothy R Baker, Simon L Lewis, Patrick Meir, Lucy Rowland, Antonio Carlos Lola da Costa, Daniel Nepstad, Oliver L Phillips
High levels of species diversity hamper current understanding of how tropical forests may respond to environmental change. In the tropics, water availability is a leading driver of the diversity and distribution of tree species, suggesting that many tropical taxa may be physiologically incapable of tolerating dry conditions, and that their distributions along moisture gradients can be used to predict their drought tolerance. While this hypothesis has been explored at local and regional scales, large continental-scale tests are lacking...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28803080/palliative-care-development-in-kyrgyzstan
#15
Aibek Mukambetov, Taalaigul Sabyrbekova, Lola Asanalieva, Ilim Sadykov, Alexander Aralbaev, Stephen Connor
Palliative care began in Kyrgyzstan in 2005 as a pilot home based care program in Osh Cancer Center and was supported by a small group of nurses and one physician from Scotland. In 2010, the Soros Foundation-Kyrgyzstan (SFK) and the Open Society Foundation's International Palliative Care Initiative (IPCI) began supporting work on palliative care policy, legislation, essential medicine availability, education, advocacy and implementation. A Ministry of Health working group was established to lead this initiative and technical assistance was provided by an international palliative care consultant...
August 9, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28771978/parent-child-relationship-associated-with-the-development-of-borderline-personality-disorder-a-systematic-review
#16
Marie-Ève Boucher, Jessica Pugliese, Catherine Allard-Chapais, Serge Lecours, Lola Ahoundova, Rachel Chouinard, Sarah Gaham
The parent-child relationship (PCR) is considered as a central factor in most contemporary theories on the aetiology of borderline personality disorder (BPD). This systematic review aimed to answer the three following questions: (1) How is the PCR described by BPD participants and their parents in comparison to other normative and clinical groups? (2) Which aspects of the PCR are specifically associated with a BPD diagnosis in adulthood? (3) How can the facets of the PCR identified in the reviewed studies shed light on the general aetiological models of BPD? Forty studies were retained and divided into three categories: perspective of BPD probands, perspective of their parents and perspective of family...
August 2, 2017: Personality and Mental Health
https://www.readbyqxmd.com/read/28759135/acute-and-long-term-administration-of-palmitoylcarnitine-induces-muscle-specific-insulin-resistance-in-mice
#17
Edgars Liepinsh, Marina Makrecka-Kuka, Elina Makarova, Kristine Volska, Karlis Vilks, Eduards Sevostjanovs, Unigunde Antone, Janis Kuka, Reinis Vilskersts, Daina Lola, Einars Loza, Solveiga Grinberga, Maija Dambrova
Acylcarnitine accumulation has been linked to perturbations in energy metabolism pathways. In this study, we demonstrate that long-chain (LC) acylcarnitines are active metabolites involved in the regulation of glucose metabolism in vivo. Single-dose administration of palmitoylcarnitine (PC) in fed mice induced marked insulin insensitivity, decreased glucose uptake in muscles, and elevated blood glucose levels. Increase in the content of LC acylcarnitine induced insulin resistance by impairing Akt phosphorylation at Ser473...
July 31, 2017: BioFactors
https://www.readbyqxmd.com/read/28758950/tgf%C3%AE-controls-ovarian-cancer-cell-proliferation
#18
REVIEW
Elisenda Alsina-Sanchís, Agnès Figueras, Alvaro Lahiguera, Marta Gil-Martín, Beatriz Pardo, Josep M Piulats, Lola Martí, Jordi Ponce, Xavier Matias-Guiu, August Vidal, Alberto Villanueva, Francesc Viñals
There have been no major improvements in the overall survival of ovarian cancer patients in recent decades. Even though more accurate surgery and more effective treatments are available, the mortality rate remains high. Given the differences in origin and the heterogeneity of these tumors, research to elucidate the signaling pathways involved is required. The Transforming Growth Factor (TGFβ) family controls different cellular responses in development and cell homeostasis. Disruption of TGFβ signaling has been implicated in many cancers, including ovarian cancer...
July 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28749571/l-ornithine-l-aspartate-in-bouts-of-overt-hepatic-encephalopathy
#19
Sandeep Singh Sidhu, Barjesh Chander Sharma, Omesh Goyal, Harsh Kishore, Navpreet Kaur
High quality data on efficacy of L-Ornithine L-Aspartate (LOLA) in cirrhotics with bouts of overt hepatic encephalopathy (OHE) is missing. We aimed to evaluate the efficacy of intravenous LOLA in reversal of bouts of OHE in cirrhotics. In this prospective double-blind randomized placebo controlled trial conducted at two tertiary care institutes in India, 370 cirrhotics with bouts of OHE were screened. After exclusion, 193 (52.16%) patients were randomized to receive either intravenous infusions of LOLA (n=98), 30 grams daily or Placebo (n=95) for 5 days...
July 27, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/28729654/cryopreservation-protocol-for-human-biliary-tree-stem-progenitors-hepatic-and-pancreatic-precursors
#20
Lorenzo Nevi, Vincenzo Cardinale, Guido Carpino, Daniele Costantini, Sabina Di Matteo, Alfredo Cantafora, Fabio Melandro, Roberto Brunelli, Carlo Bastianelli, Camilla Aliberti, Marco Monti, Daniela Bosco, Pasquale Bartolomeo Berloco, Pierluigi Benedetti Panici, Lola Reid, Eugenio Gaudio, Domenico Alvaro
Human biliary tree stem/progenitor cells (hBTSCs) are being used for cell therapies of patients with liver cirrhosis. A cryopreservation method was established to optimize sourcing of hBTSCs for these clinical programs and that comprises serum-free Kubota's Medium (KM) supplemented with 10% dimethyl sulfoxide (DMSO), 15% human serum albumin (HSA) and 0.1% hyaluronans. Cryopreserved versus freshly isolated hBTSCs were similar in vitro with respect to self-replication, stemness traits, and multipotency. They were able to differentiate to functional hepatocytes,cholangiocytes or pancreatic islets, yielding similar levels of secretion of albumin or of glucose-inducible levels of insulin...
July 20, 2017: Scientific Reports
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