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Lisa R Hirschhorn, Lola Adedokun, Abdul Ghaffar
No abstract text is available yet for this article.
December 21, 2017: BMC Health Services Research
Eva M Verdugo-Sivianes, Lola Navas, Sonia Molina-Pinelo, Irene Ferrer, Alvaro Quintanal-Villalonga, Javier Peinado, Jose M Garcia-Heredia, Blanca Felipe-Abrio, Sandra Muñoz-Galvan, Juan J Marin, Luis Montuenga, Luis Paz-Ares, Amancio Carnero
The scaffold protein Spinophilin (Spinophilin, PPP1R9B) is one of the regulatory subunits of phosphatase-1 (PP1), directing it to distinct subcellular locations and targets. The loss of Spinophilin reduces PP1 targeting to pRb, thereby maintaining higher levels of phosphorylated pRb. Spinophilin is absent or reduced in approximately 40% of human lung tumors, correlating with the malignant grade. However, little is known about the relevance of the coordinated activity or presence of Spinophilin and its reported catalytic partners in the prognosis of lung cancer...
December 1, 2017: Oncotarget
Shiri Klein, Michal Abraham, Baruch Bulvik, Elia Dery, Ido D Weiss, Neta Barashi, Rinat Abramovitch, Hanna Wald, Yaniv Harel, Devorah Olam, Lola Weiss, Katia Beider, Orly Eizenberg, Ori Wald, Eithan Galun, Yaron Pereg, Amnon Peled
CXCR4 expression in neuroblastoma (NB) tumors correlates with disease severity. In this study, we describe mechanisms by which CXCR4 signaling controls NB tumor growth and response to therapy. We found that overexpression of CXCR4 or stimulation with CXCL12 supports NB tumorigenesis. Moreover, CXCR4 inhibition with the high affinity CXCR4 antagonist, BL-8040 prevented tumor growth and reduced survival of tumor cells. These effects were mediated by the upregulation of miR-15a/16-1, which resulted in downregulation of their target genes BCL-2 and cyclin D1, as well as inhibition of ERK...
December 19, 2017: Cancer Research
Claudio Muheim, Hansjörg Götzke, Anna U Eriksson, Stina Lindberg, Ida Lauritsen, Morten H H Nørholm, Daniel O Daley
The outer membrane of gram-negative bacteria is a permeability barrier that prevents the efficient uptake of molecules with large scaffolds. As a consequence, a number of antibiotic classes are ineffective against gram-negative strains. Herein we carried out a high throughput screen for small molecules that make the outer membrane of Escherichia coli more permeable. We identified MAC13243, an inhibitor of the periplasmic chaperone LolA that traffics lipoproteins from the inner to the outer membrane. We observed that cells were (1) more permeable to the fluorescent probe 1-N-phenylnapthylamine, and (2) more susceptible to large-scaffold antibiotics when sub-inhibitory concentrations of MAC13243 were used...
December 15, 2017: Scientific Reports
Marta Díaz-Martínez, Lucía Benito-Jardón, Lola Alonso, Lisa Koetz-Ploch, Eva Hernando, Joaquin Teixido
Melanoma treatment with the BRAF V600E inhibitor vemurafenib (VMF) provides therapeutic benefits but the common emergence of drug resistance remains a challenge. We generated A375 melanoma cells resistant to VMF with the goal of investigating changes in miRNA expression patterns that might contribute to resistance. Increased expression of miR-204-5p and miR-211-5p occurring in VMF-resistant cells was determined to impact VMF response. Their expression was rapidly affected by VMF treatment through RNA stabilization...
December 11, 2017: Cancer Research
Sabu Rohini, R Aswani, M Kannan, V P Sylas, E K Radhakrishnan
Functional contribution of endophytic bacteria towards plant growth is highly impressive due to their species diversity and array of probiotic mechanisms. In the study, 96 endophytic bacteria isolated from rhizome of ginger (Zingiber officinale) were screened for phosphate solubilisation, 1-amino cyclopropane-1-carboxylate (ACC) deaminase activity, nitrogen fixation, ammonia and IAA production. Among these, sixteen endophytes with multiple plant growth-promoting activities were identified by 16S rDNA sequencing and all of them showed growth enhancement in Vigna unguiculata var Lola which make the study remarkably significant...
December 7, 2017: Current Microbiology
Nitesh Rana, Praveen Pendyala, Ryan K Cleary, Guozhen Luo, Zhiguo Zhao, Lola B Chambless, Anthony J Cmelak, Albert Attia, Mark J Stavas
Purpose: The optimal treatment strategy following local recurrence after stereotactic radiosurgery (SRS) remains unclear. While upfront SRS has been extensively studied, few reports focus on outcomes after retreatment. Here, we report the results following a second course of SRS for local recurrence of brain metastases previously treated with SRS. Methods: Using institutional database, patients who received salvage SRS (SRS2) following in-field failure of initial SRS (SRS1) for brain metastases were identified...
2017: Frontiers in Oncology
Michal Abraham, Hanna Wald, Dalit Vaizel-Ohayon, Valentin Grabovsky, Zohar Oren, Arnon Karni, Lola Weiss, Eithan Galun, Amnon Peled, Orly Eizenberg
Chemokines and their receptors play critical roles in the progression of autoimmunity and inflammation. Typically, multiple chemokines are involved in the development of these pathologies. Indeed, targeting single chemokines or chemokine receptors has failed to achieve significant clinical benefits in treating autoimmunity and inflammation. Moreover, the binding of host atypical chemokine receptors to multiple chemokines as well as the binding of chemokine-binding proteins secreted by various pathogens can serve as a strategy for controlling inflammation...
2017: Frontiers in Immunology
Nadja Dinges, Violeta Morin, Nastasja Kreim, Tony D Southall, Jean-Yves Roignant
Longitudinals lacking (lola) is one of the most complex genes in Drosophila melanogaster, encoding up to 20 protein isoforms that include key transcription factors involved in axonal pathfinding and neural reprogramming. Most previous studies have employed loss-of-function alleles that disrupt lola common exons, making it difficult to delineate isoform-specific functions. To overcome this issue, we have generated isoform-specific mutants for all isoforms using CRISPR/Cas9. This enabled us to study specific isoforms with respect to previously characterized roles for Lola and to demonstrate a specific function for one variant in axon guidance via activation of the microtubule-associated factor Futsch...
December 5, 2017: Cell Reports
Alexandra Martirossian, Shiwan Shah, Lola Carrete, Jose Valle, Vincent Valentine
Lymphangioleiomyomatosis (LAM), a rare, multisystem disorder primarily affecting women of reproductive age, is characterized by cystic-appearing lung lesions, progressive loss of lung function, chylous effusions and renal angiomyolipomas. Sirolimus, an mammalian target of rapamycin inhibitor, has been shown to stabilize lung function, reduce symptoms and resolve chylous effusions in the short term for patients with LAM. Herein, we report a premenopausal female with LAM who experienced complete and durable resolution of her chylothoraces with significant and sustained improvement in lung function on sirolimus...
December 2017: American Journal of the Medical Sciences
Kavita Kumar, Lola Loupias, Christine Canaff, Sophie Morisset, Stephane Pronier, Claudia Morais, Aurelien Habrioux, Teko Napporn, Boniface Kokoh
This work reports on the easy synthesis and characterization of a non-precious bifunctional catalyst for oxygen reduction and evolution reactions (ORR and OER). A few-layer reduced-graphene oxide (RGO) supported NiCo2O4 catalyst is prepared using a rapid and easy two-step synthesis method. It consists in the solvothermal PVP assisted assembly of metal complexes onto few-layer graphene followed by a calcination step aiming at converting metal complexes into the spinel phase. Using this synthesis approach, the most active material demonstrates an outstanding activity towards OER and ORR making it one of the best bifunctional catalysts ever reported...
December 5, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Lola Butcher
The chief medical officers at health plans and provider organizations often see the world through different lenses. Here, chief medical officers from both sides of the divide share their views.
November 2017: Managed Care
Lola Butcher
How the world looks depends on your point of view. Medical directors, some with experience as payers and providers, share their thoughts on prior authorization, value-based care, and quality measurement. One opportunity: Payers should work with specialty organizations and physician advocates to develop metrics and processes that make sense from the physician perspective.
November 2017: Managed Care
Justo Juliá, María López-Gil, Adolfo Fontenla, Álvaro Lozano, Lola Villagraz, Rafael Salguero, Fernando Arribas
Aims: Changes in the anatomical relationship between left phrenic nerve and coronary veins may occur due to the reverse remodelling observed in super-responders to cardiac resynchronization therapy (CRT) and might be the underlying mechanism in patients developing late-onset phrenic nerve stimulation (PNS) without evidence of lead dislodgement (LD). In this study, we sought to evaluate the role of super-response (SR) to CRT as a potential predictor of late-onset PNS. Methods and results: Consecutive patients implanted with a left ventricular (LV) lead in a single centre were retrospectively analysed...
November 22, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Valter R M Lombardi, Iván Carrera, Lola Corzo, Ramón Cacabelos
Many clinical conditions exist in which it is desirable to stimulate or suppress the immune system, and many different drugs are able to do this. It is also well known that nutrition may affect human health and immune responses. Nutritional factors are crucial components of the diet and essential for normal growth and development of both vertebrate and invertebrate organisms. Many of these components have been shown to play different roles in the immune response and, under different circumstances, they can significantly modulate the immune system to create an effective response...
November 24, 2017: Seminars in Cancer Biology
Bradley W Frazee, Amparo Rodríguez-Hoces de la Guardia, Harrison Alter, Carol G Chen, Eugenia L Fuentes, Alison K Holzer, Macarena Lolas, Debkishore Mitra, Jaspreet Vohra, Cornelia L Dekker
STUDY OBJECTIVE: While development is under way of accurate, point-of-care molecular tests for influenza infection, the optimal specimen type for molecular tests remains unclear. Compared with standard nasopharyngeal swab specimens, less invasive nasal swab and midturbinate swab specimens may cause less patient discomfort and be more suitable for routine emergency department (ED) testing, although possibly at the expense of diagnostic accuracy. We compare both the accuracy of a polymerase chain reaction molecular influenza test and discomfort between these 3 intranasal specimen types...
November 23, 2017: Annals of Emergency Medicine
Andrew T Hale, Li Wang, Megan K Strother, Lola B Chambless
Atypical meningioma has an aggressive clinical course. Distinguishing atypical from benign meningioma preoperatively could affect surgical planning and improve treatment outcomes. In this study, we examined whether pre-operative magnetic resonance imaging (MRI) features could distinguish between benign and atypical meningioma. Imaging factors analyzed included peritumoral edema, the presence of a draining vein, tumor necrosis, tumor location and tumor volume. Using univariate analysis, the most striking predictor of grade was tumor volume (p < ...
November 22, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Jessica Freeman, Elisabeth Murphy, Susan Woolfenden, Edward Waters, Jennifer Winters, Lola Callaghan, Karen Zwi
AIMS: To describe the engagement of a cohort of urban Aboriginal families with an Early Childhood Health Service, and to assess any association of engagement with the service with screening by the Edinburgh Post-Natal Depression Scale (EPDS), full breastfeeding rates and post-natal smoking status. METHODS: Routine electronic medical record data collected by a Child and Family Health Nurse between 2011 and 2014 was analysed retrospectively. Associations between use of the service and acceptance of EPDS, breastfeeding rates and post-natal smoking status were determined using binary and multinomial multiple logistic regression analyses...
November 23, 2017: Journal of Paediatrics and Child Health
Iris Brunner, Jan Sture Skouen, Håkon Hofstad, Jörg Aßmus, Frank Becker, Anne-Marthe Sanders, Hanne Pallesen, Lola Qvist Kristensen, Marc Michielsen, Liselot Thijs, Geert Verheyden
OBJECTIVE: To compare the effectiveness of upper extremity virtual reality rehabilitation training (VR) to time-matched conventional training (CT) in the subacute phase after stroke. METHODS: In this randomized, controlled, single-blind phase III multicenter trial, 120 participants with upper extremity motor impairment within 12 weeks after stroke were consecutively included at 5 rehabilitation institutions. Participants were randomized to either VR or CT as an adjunct to standard rehabilitation and stratified according to mild to moderate or severe hand paresis, defined as ≥20 degrees wrist and 10 degrees finger extension or less, respectively...
December 12, 2017: Neurology
Michael J Pishvaian, R Joseph Bender, Lynn M Matrisian, Lola Rahib, Andrew Hendifar, William A Hoos, Sam Mikhail, Vincent Chung, Vincent Picozzi, Craig Heartwell, Kimberly Mason, Katelyn Varieur, Metasebia Aberra, Subha Madhavan, Emanuel Petricoin, Jonathan R Brody
Recent improvements in next-generation sequencing (NGS) technology have enabled detection of biomarkers in cell-free DNA in blood and may ultimately replace invasive tissue biopsies. However, a better understanding of the performance of blood-based NGS assays is needed prior to routine clinical use. As part of an IRB-approved molecular profiling registry trial of pancreatic ductal adenocarcinoma (PDA) patients, we facilitated blood-based NGS testing of 34 patients from multiple community-based and high-volume academic oncology practices...
October 13, 2017: Oncotarget
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