keyword
MENU ▼
Read by QxMD icon Read
search

Gut microbiota and diabetes

keyword
https://www.readbyqxmd.com/read/29036231/vildagliptin-increases-butyrate-producing-bacteria-in-the-gut-of-diabetic-rats
#1
Qian Zhang, Xinhua Xiao, Ming Li, Miao Yu, Fan Ping, Jia Zheng, Tong Wang, Xiaojing Wang
Emerging evidence supports a key role for the gut microbiota in metabolic diseases, including type 2 diabetes (T2D) and obesity. The dipeptidyl peptidase-4 inhibitor vildagliptin is highly efficacious in treating T2D. However, whether vildagliptin can alter the gut microbiome is still unclear. This study aimed to identify whether vildagliptin modifies the gut microbiota structure during T2D treatment. Diabetic Sprague-Dawley (SD) rats were induced by a high-fat diet and streptozotocin injection (HFD/STZ). Diabetic rats were orally administered a low dose of vildagliptin (LV, 0...
2017: PloS One
https://www.readbyqxmd.com/read/29035308/gut-microbiota-and-nonalcoholic-fatty-liver-disease-insights-on-mechanisms-and-therapy
#2
REVIEW
Junli Ma, Qihang Zhou, Houkai Li
The gut microbiota plays critical roles in development of obese-related metabolic diseases such as nonalcoholic fatty liver disease (NAFLD), type 2 diabetes(T2D), and insulin resistance(IR), highlighting the potential of gut microbiota-targeted therapies in these diseases. There are various ways that gut microbiota can be manipulated, including through use of probiotics, prebiotics, synbiotics, antibiotics, and some active components from herbal medicines. In this review, we review the main roles of gut microbiota in mediating the development of NAFLD, and the advances in gut microbiota-targeted therapies for NAFLD in both the experimental and clinical studies, as well as the conclusions on the prospect of gut microbiota-targeted therapies in the future...
October 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29033938/early-life-nutritional-factors-and-mucosal-immunity-in-the-development-of-autoimmune-diabetes
#3
REVIEW
Ling Xiao, Belinda Van't Land, Wouter R P H van de Worp, Bernd Stahl, Gert Folkerts, Johan Garssen
Type 1 diabetes (T1D) is an immune-mediated disease with a strong genetic basis but might be influenced by non-genetic factors such as microbiome development that "programs" the immune system during early life as well. Factors influencing pathogenesis, including a leaky intestinal mucosal barrier, an aberrant gut microbiota composition, and altered immune responsiveness, offer potential targets for prevention and/or treatment of T1D through nutritional or pharmacologic means. In this review, nutritional approaches during early life in order to protect against T1D development have been discussed...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29031410/harnessing-gut-microbes-for-mental-health-getting-from-here-to-there
#4
REVIEW
Annadora J Bruce-Keller, J Michael Salbaum, Hans-Rudolf Berthoud
There has been an explosion of interest in the study of microorganisms inhabiting the gastrointestinal tract (gut microbiota) and their impact on host health and physiology. Accumulating data suggest that altered communication between gut microbiota and host systems could participate in disorders such as obesity, diabetes mellitus, and autoimmune disorders as well as neuropsychiatric disorders, including autism, anxiety, and major depressive disorders. The conceptual development of the microbiome-gut-brain axis has facilitated understanding of the complex and bidirectional networks between gastrointestinal microbiota and their host, highlighting potential mechanisms through which this environment influences central nervous system physiology...
August 30, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29026604/transglucosidase-improves-the-bowel-movements-in-type-2-diabetes-mellitus-patients-a-preliminary-randomized-double-blind-placebo-controlled-study
#5
Akihiro Shimozato, Makoto Sasaki, Naotaka Ogasawara, Yasushi Funaki, Masahide Ebi, Chiho Goto, Satoshi Koikeda, Takashi Joh, Kunio Kasugai
BACKGROUND: Recent studies have highlighted the relationship between gut microbiota and bowel movements. OBJECTIVE: We aimed to evaluate transglucosidase treatment efficacy for bowel movements in patients with type 2 diabetes mellitus and to clarify the relationship between bowel movements, dietary habits, gut microbiota and fecal short-chain fatty acids. METHODS: In this randomized double-blind, placebo-controlled study, 66 patients received placebo or transglucosidase (300 or 900 mg/day) orally, for 12 weeks...
October 2017: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/29025837/effects-of-lactobacillus-rhamnosus-gg-and-bifidobacterium-lactis-bb12-on-beta-cell-function-in-children-with-newly-diagnosed-type-1-diabetes-protocol-of-a-randomised-controlled-trial
#6
Lidia Groele, Hania Szajewska, Agnieszka Szypowska
INTRODUCTION: Recent evidence has demonstrated that, among other factors, dysbiosis (imbalances in the composition and function of the gut microbiota) may be relevant in the development of type 1 diabetes (T1D). Thus, gut microbiota may be a target for improving outcomes in subjects with T1D. The aim of the study is to examine the effects of Lactobacillus rhamnosus GG and Bifidobacterium lactis Bb12 on beta-cell function in children with newly diagnosed T1D. METHODS AND ANALYSIS: A total of 96 children aged 8 to 17 years with newly diagnosed T1D, confirmed by clinical history and the presence of at least one positive autoantibody, will be enrolled in a double-blind, randomised, placebo-controlled trial in which they will receive L...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/29022388/our-gut-microbiota-a-long-walk-to-homeostasis
#7
L M T Dicks, J Geldenhuys, L S Mikkelsen, E Brandsborg, H Marcotte
The microbiome of the human gastrointestinal tract (GIT) consists of billions of bacteria, fungi and viruses, of which bacteria play the most important role in nutrition, immune development, production of vitamins and maintaining a well-balanced (homeostatic) microbial population. Many papers have been published on the microbiota in the human GIT, but little is known about the first group of bacteria that colonises an infant. The intestinal tract of an unborn is, despite general belief, not sterile, but contains bacteria that have been transferred from the mother...
October 12, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/29021903/-clostridium-mediterraneense-a-new-bacterial-species-isolated-from-the-human-gut
#8
S Ndongo, N Cassir, J Delerce, D Raoult, B La Scola
We report the main characteristics of 'Clostridium mediterraneense' sp. nov., strain Marseille-P2434(T) (CSUR P2434), a new species within the genus Clostridium. This strain was isolated from the gut microbiota of a 66-year-old diabetic patient in Marseille, France.
November 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/29021286/pomegranate-juice-but-not-an-extract-confers-a-lower-glycemic-response-on-a-high-glycemic-index-food-randomized-crossover-controlled-trials-in-healthy-subjects
#9
Asimina Kerimi, Hilda Nyambe-Silavwe, Julia S Gauer, Francisco A Tomás-Barberán, Gary Williamson
Background: Low-glycemic index diets have demonstrated health benefits associated with a reduced risk of developing type 2 diabetes.Objectives: We tested whether pomegranate polyphenols could lower the glycemic response of a high-glycemic index food when consumed together and the mechanism by which this might occur.Design: We compared the acute effect of a pomegranate juice and a polyphenol-rich extract from pomegranate (supplement) on the bread-derived postprandial blood glucose concentration in 2 randomized, crossover, controlled studies (double-blinded for the supplements), each on 16 healthy volunteers...
October 11, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29018410/next-generation-beneficial-microbes-the-case-of-akkermansia-muciniphila
#10
REVIEW
Patrice D Cani, Willem M de Vos
Metabolic disorders associated with obesity and cardiometabolic disorders are worldwide epidemic. Among the different environmental factors, the gut microbiota is now considered as a key player interfering with energy metabolism and host susceptibility to several non-communicable diseases. Among the next-generation beneficial microbes that have been identified, Akkermansia muciniphila is a promising candidate. Indeed, A. muciniphila is inversely associated with obesity, diabetes, cardiometabolic diseases and low-grade inflammation...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29018189/the-gut-microbiome-in-atherosclerotic-cardiovascular-disease
#11
Zhuye Jie, Huihua Xia, Shi-Long Zhong, Qiang Feng, Shenghui Li, Suisha Liang, Huanzi Zhong, Zhipeng Liu, Yuan Gao, Hui Zhao, Dongya Zhang, Zheng Su, Zhiwei Fang, Zhou Lan, Junhua Li, Liang Xiao, Jun Li, Ruijun Li, Xiaoping Li, Fei Li, Huahui Ren, Yan Huang, Yangqing Peng, Guanglei Li, Bo Wen, Bo Dong, Ji-Yan Chen, Qing-Shan Geng, Zhi-Wei Zhang, Huanming Yang, Jian Wang, Jun Wang, Xuan Zhang, Lise Madsen, Susanne Brix, Guang Ning, Xun Xu, Xin Liu, Yong Hou, Huijue Jia, Kunlun He, Karsten Kristiansen
The gut microbiota has been linked to cardiovascular diseases. However, the composition and functional capacity of the gut microbiome in relation to cardiovascular diseases have not been systematically examined. Here, we perform a metagenome-wide association study on stools from 218 individuals with atherosclerotic cardiovascular disease (ACVD) and 187 healthy controls. The ACVD gut microbiome deviates from the healthy status by increased abundance of Enterobacteriaceae and Streptococcus spp. and, functionally, in the potential for metabolism or transport of several molecules important for cardiovascular health...
October 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28991267/cytotoxic-and-regulatory-roles-of-mucosal-associated-invariant-t-cells-in-type-1-diabetes
#12
Ophélie Rouxel, Jennifer Da Silva, Lucie Beaudoin, Isabelle Nel, Céline Tard, Lucie Cagninacci, Badr Kiaf, Masaya Oshima, Marc Diedisheim, Marion Salou, Alexandra Corbett, Jamie Rossjohn, James McCluskey, Raphael Scharfmann, Manuela Battaglia, Michel Polak, Olivier Lantz, Jacques Beltrand, Agnès Lehuen
Type 1 diabetes (T1D) is an autoimmune disease that results from the destruction of pancreatic β-cells by the immune system that involves innate and adaptive immune cells. Mucosal-associated invariant T cells (MAIT cells) are innate-like T-cells that recognize derivatives of precursors of bacterial riboflavin presented by the major histocompatibility complex (MHC) class I-related molecule MR1. Since T1D is associated with modification of the gut microbiota, we investigated MAIT cells in this pathology. In patients with T1D and mice of the non-obese diabetic (NOD) strain, we detected alterations in MAIT cells, including increased production of granzyme B, which occurred before the onset of diabetes...
October 9, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28990516/gut-microbiota-as-a-therapeutic-target-for-metabolic-disorders
#13
Hirofumi Okubo, Yusuke Nakatsu, Akifumi Kushiyama, Takeshi Yamamotoya, Yasuka Matsunaga, Masa-Ki Inoue, Midori Fujishiro, Hideaki Sakoda, Haruya Ohno, Masayasu Yoneda, Hiraku Ono, Tomoichiro Asano
The prevalence of metabolic disorders has been rising worldwide, making the identification of factors affecting metabolic control more important than ever. Gut microbiota play a vital role not only in the digestion and absorption of nutrients, but also in homeostatic maintenance of host immunity, metabolism and the gut barrier. It was recently suggested that gut microbiota alterations contribute to the pathogenesis of metabolic disorders such as obesity, diabetes mellitus and non-alcoholic fatty liver disease...
October 9, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28983192/the-role-of-polyphenols-in-modern-nutrition
#14
REVIEW
G Williamson
Polyphenols are found in plant-based foods and beverages, notably apples, berries, citrus fruit, plums, broccoli, cocoa, tea and coffee and many others. There is substantial epidemiological evidence that a diet high in polyphenol-rich fruit, vegetables, cocoa and beverages protects against developing cardiovascular disease and type 2 diabetes. The absorption and metabolism of these compounds have been well described and, for many, the gut microbiota play a critical role in absorption; taking into consideration the parent compound and the metabolites from colon bacteria catabolism, more than 80% of a dose can be absorbed and ultimately excreted in the urine...
September 2017: Nutrition Bulletin
https://www.readbyqxmd.com/read/28980079/gut-microbiota-aberrations-precede-diagnosis-of-gestational-diabetes-mellitus
#15
Kati Mokkala, Noora Houttu, Tero Vahlberg, Eveliina Munukka, Tapani Rönnemaa, Kirsi Laitinen
No abstract text is available yet for this article.
October 4, 2017: Acta Diabetologica
https://www.readbyqxmd.com/read/28976454/the-gut-and-its-microbiome-as-related-to-central-nervous-system-functioning-and-psychological-well-being-introduction-to-the-special-issue-of-psychosomatic-medicine
#16
Emeran A Mayer, Elaine Y Hsiao
Accumulating evidence indicates bidirectional associations between the brain and the gut microbiome with both top-down and bottom-up processes. This article describes new developments in brain-gut interactions as an introduction to a special issue of Psychosomatic Medicine, based on a joint symposium of the American Psychosomatic Society and the American Gastroenterological Association. Literature review articles indicate that several psychiatric disorders are associated with altered gut microbiota, whereas evidence linking functional gastrointestinal disorders and dysbiosis has not been firmly established...
October 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28973971/effects-of-antidiabetic-drugs-on-gut-microbiota-composition
#17
REVIEW
Sophie A Montandon, François R Jornayvaz
Gut microbiota forms a catalog of about 1000 bacterial species; which mainly belong to the Firmicutes and Bacteroidetes phyla. Microbial genes are essential for key metabolic processes; such as the biosynthesis of short-chain fatty acids (SCFA); amino acids; bile acids or vitamins. It is becoming clear that gut microbiota is playing a prevalent role in pathologies such as metabolic syndrome; type 2 diabetes (T2D); inflammatory and bowel diseases. Obesity and related diseases; notably type 2 diabetes, induce gut dysbiosis...
September 30, 2017: Genes
https://www.readbyqxmd.com/read/28970836/fructose-a-dietary-sugar-in-crosstalk-with-microbiota-contributing-to-the-development-and-progression-of-non-alcoholic-liver-disease
#18
REVIEW
Jessica Lambertz, Sabine Weiskirchen, Silvano Landert, Ralf Weiskirchen
Fructose is one of the key dietary catalysts in the development of non-alcoholic fatty liver disease (NAFLD). NAFLD comprises a complex disease spectrum, including steatosis (fatty liver), non-alcoholic steatohepatitis, hepatocyte injury, inflammation, and fibrosis. It is also the hepatic manifestation of the metabolic syndrome, which covers abdominal obesity, insulin resistance, dyslipidemia, glucose intolerance, or type 2 diabetes mellitus. Commensal bacteria modulate the host immune system, protect against exogenous pathogens, and are gatekeepers in intestinal barrier function and maturation...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28968517/probiotics-modulate-gut-microbiota-and-improve-insulin-sensitivity-in-dio-mice
#19
Renata A Bagarolli, Natália Tobar, Alexandre G Oliveira, Tiago G Araújo, Bruno M Carvalho, Guilherme Z Rocha, Juliana F Vecina, Kelly Calisto, Dioze Guadagnini, Patrícia O Prada, Andrey Santos, Sara T O Saad, Mario J A Saad
Obesity and type 2 diabetes are characterized by subclinical inflammatory process. Changes in composition or modulation of the gut microbiota may play an important role in the obesity-associated inflammatory process. In the current study, we evaluated the effects of probiotics (Lactobacillus rhamnosus, L. acidophilus and Bifidobacterium bifidumi) on gut microbiota, changes in permeability, and insulin sensitivity and signaling in high-fat diet and control animals. More importantly, we investigated the effects of these gut modulations on hypothalamic control of food intake, and insulin and leptin signaling...
August 26, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28966614/detection-of-increased-plasma-interleukin-6-levels-and-prevalence-of-prevotella-copri-and-bacteroides-vulgatus-in-the-feces-of-type-2-diabetes-patients
#20
Aline Zazeri Leite, Nathália de Campos Rodrigues, Marina Ignácio Gonzaga, João Carlos Cicogna Paiolo, Carolina Arantes de Souza, Nadine Aparecida Vicentini Stefanutto, Wellington Pine Omori, Daniel Guariz Pinheiro, João Luiz Brisotti, Euclides Matheucci Junior, Vânia Sammartino Mariano, Gislane Lelis Vilela de Oliveira
Intestinal dysbiosis and metabolic endotoxemia have been associated with metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes (T2D). The main goal of the present study was to evaluate the intestinal dysbiosis in Brazilian T2D patients and correlate these data with inflammatory cytokines and lipopolysaccharides (LPS) plasma concentrations. This study was approved by the Ethics Committees from Barretos Cancer Hospital and all individuals signed the informed consent form. Stool samples were required for DNA extraction, and the V3/V4 regions of bacterial 16S were sequenced using an Illumina platform...
2017: Frontiers in Immunology
keyword
keyword
84115
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"