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Acidification

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https://www.readbyqxmd.com/read/28830065/effect-of-biochar-and-fe-biochar-on-cd-and-as-mobility-and-transfer-in-soil-rice-system
#1
Daixia Yin, Xin Wang, Bo Peng, Changyin Tan, Lena Q Ma
In this study, the effects of biochar derived from rice-straw (biochar) and iron-impregnated biochar (Fe-biochar) on Cd and As mobility in rice rhizosphere and transfer from soil to rice were investigated with different application rates. 1-3% biochar reduced porewater Cd in rhizosphere but elevated soluble As, resulting in 49-68% and 26-49% reduction in the root and grain Cd, with a simultaneous increase in root As. Unlike biochar, 0.5% Fe-biochar decreased porewater As throughout rice growth, resulting in reduced root As, which, however, increased Cd uptake by root...
July 26, 2017: Chemosphere
https://www.readbyqxmd.com/read/28827680/chemotherapy-with-cisplatin-insights-into-intracellular-ph-and-metabolic-landscape-of-cancer-cells-in-vitro-and-in-vivo
#2
Marina V Shirmanova, Irina N Druzhkova, Maria M Lukina, Varvara V Dudenkova, Nadezhda I Ignatova, Ludmila B Snopova, Vladislav I Shcheslavskiy, Vsevolod V Belousov, Elena V Zagaynova
Although cisplatin plays a central role in cancer chemotherapy, the mechanisms of cell response to this drug have been unexplored. The present study demonstrates the relationships between the intracellular pH (pHi), cell bioenergetics and the response of cervical cancer to cisplatin. pHi was measured using genetically encoded sensor SypHer2 and metabolic state was accessed by fluorescence intensities and lifetimes of endogenous cofactors NAD(P)H and FAD. Our data support the notion that cisplatin induces acidification of the cytoplasm early after the treatment...
August 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28821352/towards-optimisation-of-induced-pluripotent-cell-culture-extracellular-acidification-results-in-growth-arrest-of-ipsc-prior-to-nutrient-exhaustion
#3
Anja Wilmes, Caroline Rauch, Giada Carta, Georg Kern, Florian Meier, Wilfried Posch, Doris Wilflingseder, Lyle Armstrong, Majlinda Lako, Mario Beilmann, Gerhard Gstraunthaler, Paul Jennings
Human induced pluripotent stem cells (iPSC) have the potential to radically reduce the number of animals used in both toxicological science and disease elucidation. One initial obstacle culturing iPSC is that they require daily medium exchange. This study attempts to clarify why and propose some practical solutions. Two iPSC lineages were fed at different intervals in a full growth area (FGA) or a restricted growth area (RGA). The FGA consisted of a well coated with Matrigel™ and the RGA consisted of a coated coverslip placed in a well...
August 15, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28819106/identification-and-characterization-of-a-bacterial-homolog-of-chloride-intracellular-channel-clic-protein
#4
Shubha Gururaja Rao, Devasena Ponnalagu, Sowmya Sukur, Harkewal Singh, Shridhar Sanghvi, Yixiao Mei, Ding J Jin, Harpreet Singh
Chloride intracellular channels (CLIC) are non-classical ion channels lacking a signal sequence for membrane targeting. In eukaryotes, they are implicated in cell volume regulation, acidification, and cell cycle. CLICs resemble the omega class of Glutathione S-transferases (GST), yet differ from them in their ability to form ion channels. They are ubiquitously found in eukaryotes but no prokaryotic homolog has been characterized. We found that indanyloxyacetic acid-94 (IAA-94), a blocker of CLICs, delays the growth of Escherichia coli...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819100/blockage-of-the-lysosome-dependent-autophagic-pathway-contributes-to-complement-membrane-attack-complex-induced-podocyte-injury-in-idiopathic-membranous-nephropathy
#5
Wei Jing Liu, Zhi-Hang Li, Xiao-Cui Chen, Xiao-Lu Zhao, Zhen Zhong, Chen Yang, Hong-Luan Wu, Ning An, Wei-Yan Li, Hua-Feng Liu
Dysregulation of autophagy-mediated podocyte homeostasis is proposed to play a role in idiopathic membranous nephropathy (IMN). In the present study, autophagic activity and lysosomal alterations were investigated in podocytes of IMN patients and in cultured podocytes exposed to sublytic terminal complement complex, C5b-9. C5b-9 upregulated the number of LC3 positive puncta and the expression of p62 in patient podocytes and in C5b-9 injuried podocyte model. The lysosomal turnover of LC3-II was not influenced, although the BECN1 expression level was upregulated after exposure of podocytes to C5b-9...
August 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28816385/contrasting-physiological-responses-to-future-ocean-acidification-among-arctic-copepod-populations
#6
Peter Thor, Allison Bailey, Sam Dupont, Piero Calosi, Janne E Søreide, Pierre De Wit, Ella Guscelli, Lea Loubet-Sartrou, Ida Marie Deichmann, Martin M Candee, Camilla Svensen, Andrew L King, Richard G J Bellerby
Widespread ocean acidification (OA) is modifying the chemistry of the global ocean, and the Arctic is recognised as the region where the changes will progress at the fastest rate. Moreover, Arctic species show lower capacity for cellular homeostasis and acid-base regulation rendering them particularly vulnerable to OA. In the present study, we found physiological differences in OA response across geographically separated populations of the keystone Arctic copepod Calanus glacialis. In copepodite stage CIV, measured reaction norms of ingestion rate and metabolic rate showed severe reductions in ingestion and increased metabolic expenses in two populations from Svalbard (Kongsfjord and Billefjord) whereas no effects were observed in a population from the Disko Bay, West Greenland...
August 17, 2017: Global Change Biology
https://www.readbyqxmd.com/read/28815648/direct-uptake-of-hco3-in-the-marine-angiosperm-posidonia-oceanica-l-delile-driven-by-a-plasma-membrane-h-economy
#7
Lourdes Rubio, Delia García, María J García-Sánchez, F Xavier Niell, Hubert H Felle, José A Fernández
Seagrasses access HCO3(-) for photosynthesis by two mechanisms, apoplastic carbonic anhydrase-mediated dehydration of HCO3(-) to CO2 , and direct HCO3(-) uptake. Here we have studied plasma membrane energization and the mechanism for HCO3(-) import in Posidonia oceanica. Classical electrophysiology and ion selective microelectrodes were used to measure the membrane potential, cytosolic pH and the cytosolic concentrations of Na(+) and Cl(-) upon the addition of HCO3(-) . The photosynthetic response to HCO3(-) and to inhibitors was also measured...
August 16, 2017: Plant, Cell & Environment
https://www.readbyqxmd.com/read/28814651/n2-fixing-tropical-legume-evolution-a-contributor-to-enhanced-weathering-through-the-cenozoic
#8
REVIEW
Dimitar Z Epihov, Sarah A Batterman, Lars O Hedin, Jonathan R Leake, Lisa M Smith, David J Beerling
Fossil and phylogenetic evidence indicates legume-rich modern tropical forests replaced Late Cretaceous palm-dominated tropical forests across four continents during the early Cenozoic (58-42 Ma). Tropical legume trees can transform ecosystems via their ability to fix dinitrogen (N2) and higher leaf N compared with non-legumes (35-65%), but it is unclear how their evolutionary rise contributed to silicate weathering, the long-term sink for atmospheric carbon dioxide (CO2). Here we hypothesize that the increasing abundance of N2-fixing legumes in tropical forests amplified silicate weathering rates by increased input of fixed nitrogen (N) to terrestrial ecosystems via interrelated mechanisms including increasing microbial respiration and soil acidification, and stimulating forest net primary productivity...
August 16, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28813780/microbial-diversity-of-commercial-makgeolli-and-its-influence-on-the-organoleptic-characteristics-of-korean-rice-sourdough-jeung-pyun
#9
Jaehyung Park, Ji Sun Seo, Seul-Ah Kim, So-Yeon Shin, Jong-Hyun Park, Nam Soo Han
Sourdough is made by fermentation of dough by lactic acid bacteria (LAB) and yeast to improve bread properties like volume, flavor, and texture. A Korean traditional sourdough was made by fermenting rice flour with rice wine (makgeolli) and used to make sponge-like bread (Jeung-pyun). The aim of this study was to investigate the microbial diversity of makgeolli products and their influence on the organoleptic quality of Jeung-pyun. Three commercial makgeolli were tested for Jeung-pyun production, with each product exhibiting varied dough swelling rates and organoleptic qualities, and among them, J-product was ranked highest in texture and taste...
August 17, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28813506/global-and-local-disturbances-interact-to-modify-seagrass-palatability
#10
Rocío Jiménez-Ramos, Luis G Egea, María J Ortega, Ignacio Hernández, Juan J Vergara, Fernando G Brun
Global change, such as warming and ocean acidification, and local anthropogenic disturbances, such as eutrophication, can have profound impacts on marine organisms. However, we are far from being able to predict the outcome of multiple interacting disturbances on seagrass communities. Herbivores are key in determining plant community structure and the transfer of energy up the food web. Global and local disturbances may alter the ecological role of herbivory by modifying leaf palatability (i.e. leaf traits) and consequently, the feeding patterns of herbivores...
2017: PloS One
https://www.readbyqxmd.com/read/28813504/effect-of-co2-induced-seawater-acidification-on-growth-photosynthesis-and-inorganic-carbon-acquisition-of-the-harmful-bloom-forming-marine-microalga-karenia-mikimotoi
#11
Shunxin Hu, Bin Zhou, You Wang, Ying Wang, Xinxin Zhang, Yan Zhao, Xinyu Zhao, Xuexi Tang
Karenia mikimotoi is a widespread, toxic and non-calcifying dinoflagellate, which can release and produce ichthyotoxins and hemolytic toxins affecting the food web within the area of its bloom. Shifts in the physiological characteristics of K. mikimotoi due to CO2-induced seawater acidification could alter the occurrence, severity and impacts of harmful algal blooms (HABs). Here, we investigated the effects of elevated pCO2 on the physiology of K. mikimotoi. Using semi-continuous cultures under controlled laboratory conditions, growth, photosynthesis and inorganic carbon acquisition were determined over 4-6 week incubations at ambient (390ppmv) and elevated pCO2 levels (1000 ppmv and 2000 ppmv)...
2017: PloS One
https://www.readbyqxmd.com/read/28812677/species-specific-responses-to-ocean-acidification-should-account-for-local-adaptation-and-adaptive-plasticity
#12
Cristian A Vargas, Nelson A Lagos, Marco A Lardies, Cristian Duarte, Patricio H Manríquez, Victor M Aguilera, Bernardo Broitman, Steve Widdicombe, Sam Dupont
Global stressors, such as ocean acidification, constitute a rapidly emerging and significant problem for marine organisms, ecosystem functioning and services. The coastal ecosystems of the Humboldt Current System (HCS) off Chile harbour a broad physical-chemical latitudinal and temporal gradient with considerable patchiness in local oceanographic conditions. This heterogeneity may, in turn, modulate the specific tolerances of organisms to climate stress in species with populations distributed along this environmental gradient...
March 13, 2017: Nature ecology & evolution
https://www.readbyqxmd.com/read/28811673/improving-a-genetically-encoded-voltage-indicator-by-modifying-the-cytoplasmic-charge-composition
#13
Sungmoo Lee, Tristan Geiller, Arong Jung, Ryuichi Nakajima, Yoon-Kyu Song, Bradley J Baker
An improved genetically encoded voltage indicator (GEVI) was achieved by altering the charge composition of the region linking the voltage-sensing domain of the GEVI to a pH-sensitive fluorescent protein. Negatively charged linker segments reduced the voltage-dependent optical signal while positively charged linkers increased the signal size. Arginine scanning mutagenesis of the linker region improved the signal size of the GEVI, Bongwoori, yielding fluorescent signals as high as 20% ΔF/F during the firing of action potentials...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811018/direct-coupling-of-electromembrane-extraction-to-mass-spectrometry-advancing-the-probe-functionality-toward-measurements-of-zwitterionic-drug-metabolites
#14
Torstein Kige Rye, David Fuchs, Stig Pedersen-Bjergaard, Nickolaj Jacob Petersen
A triple-flow electromembrane extraction (EME) probe was developed and coupled directly to electrospray-ionization mass spectrometry (ESI-MS). Metabolic reaction mixtures (pH 7.4) containing drug substances and related metabolites were continuously drawn (20 μL/min) into the EME probe in one flow channel, and mixed inside the probe with 7.5 μL min(-1) of 1 M formic acid as make-up flow from a second flow channel. Following this acidification, the drug substances and their related metabolites were continuously extracted by EME at 400 V, across a supported liquid membrane (SLM) comprising 2-nitrophenyl octyl ether (and for some experiments containing 30% triphenyl phosphate (TPP)), and into 20 μL min(-1) of formic acid as acceptor phase, which was introduced through a third flow channel...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28809546/staphylococcus-aureus-cidc-is-a-pyruvate-menaquinone-oxidoreductase
#15
Xinyan Zhang, Kenneth W Bayles, Sorin Luca
Recent studies have revealed an important role for the Staphylococcus aureus CidC enzyme in cell death during the stationary phase and in biofilm development, and have contributed to our understanding of the metabolic processes important in the induction of bacterial programmed cell death (PCD). To gain more insight into the characteristics of this enzyme, we performed an in-depth biochemical and biophysical analysis of its catalytic properties. In vitro experiments show that this flavoprotein catalyzes the oxidative decarboxylation of pyruvate to acetate and carbon dioxide...
August 15, 2017: Biochemistry
https://www.readbyqxmd.com/read/28809480/rapid-life-cycle-impact-screening-using-artificial-neural-networks
#16
Runsheng Song, Arturo A Keller, Sangwon Suh
The number of chemicals in the market is rapidly increasing, while our understanding of the life-cycle impacts of these chemicals lags considerably. To address this, we developed deep Artificial Neural Network (ANN) models to estimate life-cycle impacts of chemicals. Using molecular structure information, we trained multilayer ANNs for life-cycle impacts of chemicals using six impact categories, including cumulative energy demand, global warming (IPCC 2007), acidification (TRACI), human health (Impact2000+), ecosystem quality (Impact2000+), and eco-indicator 99 (I,I, total)...
August 15, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28808054/mst4-phosphorylates-acap4-to-orchestrate-apical-membrane-remodeling-during-gastric-acid-secretion
#17
Xiao Yuan, Phil Y Yao, Jiying Jiang, Yin Zhang, Zeqi Su, Wendy Yao, Xueying Wang, Ping Gui, McKay Mullen, Calmour Henry, Tarsha Ward, Wenwen Wang, Larry Brako, Ruijun Tian, Xuannv Zhao, Fengsong Wang, Xinwang Cao, Dongmei Wang, Xing Liu, Xia Ding, Xuebiao Yao
The digestion in the stomach depends on acidification of the lumen. Histamine-elicited acid secretion is triggered by activation of PKA cascade, which ultimately results in the insertion of gastric H,K-ATPases into the apical plasma membranes of parietal cells. Our recent study revealed the functional role of PKA-MST4-ezrin signaling axis in histamine-elicited acid secretion (Jiang et al., 2015. J. Biol. Chem. 290, 28272-28285). However, it remains uncharacterized how PKA-MST4-ezrin signaling axis operates the insertion of H,K-ATPases into the apical plasma membranes of gastric parietal cells...
August 14, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28808024/structural-and-functional-studies-of-pyruvate-carboxylase-regulation-by-cyclic-di-amp-in-lactic-acid-bacteria
#18
Philip H Choi, Thu Minh Ngoc Vu, Huong Thi Pham, Joshua J Woodward, Mark S Turner, Liang Tong
Cyclic di-3',5'-adenosine monophosphate (c-di-AMP) is a broadly conserved bacterial second messenger that has been implicated in a wide range of cellular processes. Our earlier studies showed that c-di-AMP regulates central metabolism in Listeria monocytogenes by inhibiting its pyruvate carboxylase (LmPC), a biotin-dependent enzyme with biotin carboxylase (BC) and carboxyltransferase (CT) activities. We report here structural, biochemical, and functional studies on the inhibition of Lactococcus lactis PC (LlPC) by c-di-AMP...
August 14, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28807815/bcl-xl-knockout-attenuates-mitochondrial-respiration-and-causes-oxidative-stress-that-is-compensated-by-pentose-phosphate-pathway-activity
#19
Annika Pfeiffer, Julia Schneider, Diones Bueno, Amalia Dolga, Timo-Daniel Voss, Jan Lewerenz, Verena Wüllner, Axel Methner
Bcl-xL is an anti-apoptotic protein that localizes to the outer mitochondrial membrane and influences mitochondrial bioenergetics by controlling Ca(2+) influx into mitochondria. Here, we analyzed the effect of mitochondrial Bcl-xL on mitochondrial shape and function in knockout (KO), wild type and rescued mouse embryonic fibroblast cell lines. Mitochondria of KO cells were more fragmented, exhibited a reduced ATP concentration, and reduced oxidative phosphorylation (OXPHOS) suggesting an increased importance of ATP generation by other means...
August 12, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28806687/mineralization-defects-are-comparable-in-fluorotic-impacted-human-teeth-and-fluorotic-mouse-incisors
#20
Rozita Jalali, Franck Guy, Samaneh Ghazanfari, Don Lyaruu, Leo van Ruijven, Pamela DenBesten, Stefania Martignon, Gina Castiblanco, Antonius L J J Bronckers
OBJECTIVE: Fluoride excess of 0.05-0.07mgF/kgbw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet. Recent studies in rodents suggest that development of enamel fluorosis is associated with insufficient neutralization of protons released during the formation of hypermineralized lines. DESIGN: Here we examined whether hypermineralization could also be assessed by MicroCT in developing molar enamel of humans exposed to fluoride...
July 29, 2017: Archives of Oral Biology
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