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https://www.readbyqxmd.com/read/29429363/recent-advances-in-the-management-of-chronic-migraine-in-children
#1
Marco Antônio Arruda, Camila Flaksberg Chevis, Marcelo Eduardo Bigal
Migraine is a chronic-recurrent disorder that progresses in some adults and also in many children. Chronic migraine (CM) is the clinical result of this process. Since migraine does not progress in most children, identifying the risk factors for progression is an important public health priority that should be matched by evidence-based treatment. Areas covered: Herein we conduct a systematic review on the comorbidities and treatment of CM in children and adolescents in the last ten years, summarizing evidence-based recommendations for disease management...
February 10, 2018: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/29427488/global-epidemiology-of-non-alcoholic-fatty-liver-disease-non-alcoholic-steatohepatitis-what-we-need-in-the-future
#2
REVIEW
Ana Ruth Araújo, Natalia Rosso, Giorgio Bedogni, Claudio Tiribelli, Stefano Bellentani
The estimated prevalence of non-alcoholic fatty liver disease (NAFLD) worldwide is approximately 25%. However, the real prevalence of NAFLD and the associated disorders is unknown mainly because reliable and applicable diagnostic tests are lacking. This is further complicated by the lack of consensus on the terminology of different entities such as NAFLD or nonalcoholic steatohepatitis (NASH). Although assessing fatty infiltration in the liver is simple by ultrasound, the gold standard for the assessment of fibrosis, the only marker of progression towards more severe liver disease is still liver biopsy...
February 2018: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/29390863/a-civic-engagement-approach-to-encourage-healthy-eating-and-active-living-in-rural-towns-the-heart-club-pilot-project
#3
Rebecca A Seguin, Urshila Sriram, Leah M Connor, Ashley E Silver, Beining Niu, Alexis N Bartholomew
PURPOSE: To assess the feasibility and effectiveness of a civic engagement curriculum (encouraging Healthy Eating and Activity in Rural Towns [HEART] Club) designed to engage rural residents in improving their local food or physical activity environment. DESIGN: Pre-post surveys and focus groups. SETTING: Three rural Northeastern towns in the United States. PARTICIPANTS: Twenty-six rural residents (7-12 per town) recruited by local extension educators...
January 1, 2018: American Journal of Health Promotion: AJHP
https://www.readbyqxmd.com/read/29378667/saving-lives-at-birth-development-of-a-retrospective-theory-of-change-impact-framework-and-prioritised-metrics
#4
Marek Lalli, Harriet Ruysen, Hannah Blencowe, Kristen Yee, Karen Clune, Mary DeSilva, Marissa Leffler, Emily Hillman, Haitham El-Noush, Jo Mulligan, Jeffrey C Murray, Karlee Silver, Joy E Lawn
BACKGROUND: Grand Challenges for international health and development initiatives have received substantial funding to tackle unsolved problems; however, evidence of their effectiveness in achieving change is lacking. A theory of change may provide a useful tool to track progress towards desired outcomes. The Saving Lives at Birth partnership aims to address inequities in maternal-newborn survival through the provision of strategic investments for the development, testing and transition-to-scale of ground-breaking prevention and treatment approaches with the potential to leapfrog conventional healthcare approaches in low resource settings...
January 29, 2018: Globalization and Health
https://www.readbyqxmd.com/read/29302865/global-polio-eradication-way-ahead
#5
Sunil Bahl, Pankaj Bhatnagar, Roland W Sutter, Sigrun Roesel, Michel Zaffran
In 1988, the World Health Assembly resolved to eradicate poliomyelitis by the year 2000. Although substantial progress was achieved by 2000, global polio eradication proved elusive. In India, the goal was accomplished in 2011, and the entire South-East Asia Region was certified as polio-free in 2014. The year 2016 marks the lowest wild poliovirus type 1 case count ever, the lowest number of polio-endemic countries (Afghanistan, Nigeria and Pakistan), the maintenance of wild poliovirus type 2 eradication, and the continued absence of wild poliovirus type 3 detection since 2012...
January 5, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29297390/methodology-for-a-mixed-methods-multi-country-study-to-assess-recognition-of-and-response-to-maternal-and-newborn-illness
#6
Allisyn C Moran, Danielle Charlet, Supriya Madhavan, Kumudha Aruldas, Marie Donaldson, Fatuma Manzi, Monica Okuga, Alfonso Rosales, Vandana Sharma, Michael Celone, Neal Brandes, James M Sherry
BACKGROUND: Although maternal and newborn mortality have decreased 44 and 46% respectively between 1990 and 2015, achievement of ambitious Sustainable Development Goal targets requires accelerated progress. Mortality reduction requires a renewed focus on the continuum of maternal and newborn care from the household to the health facility. Although barriers to accessing skilled care are documented for specific contexts, there is a lack of systematic evidence on how women and families identify maternal and newborn illness and make decisions and subsequent care-seeking patterns...
December 21, 2017: Journal of Health, Population, and Nutrition
https://www.readbyqxmd.com/read/29237794/recommendations-of-the-global-multiple-system-atrophy-research-roadmap-meeting
#7
REVIEW
Ryan R Walsh, Florian Krismer, Wendy R Galpern, Gregor K Wenning, Phillip A Low, Glenda Halliday, Walter J Koroshetz, Janice Holton, Niall P Quinn, Olivier Rascol, Leslie M Shaw, David Eidelberg, Pam Bower, Jeffrey L Cummings, Victor Abler, Judy Biedenharn, Gal Bitan, David J Brooks, Patrik Brundin, Hubert Fernandez, Philip Fortier, Roy Freeman, Thomas Gasser, Art Hewitt, Günter U Höglinger, Matt J Huentelman, Poul H Jensen, Andreas Jeromin, Un Jung Kang, Horacio Kaufmann, Lawrence Kellerman, Vikram Khurana, Thomas Klockgether, Woojin Scott Kim, Carol Langer, Peter LeWitt, Eliezer Masliah, Wassilios Meissner, Ronald Melki, Susanne Ostrowitzki, Steven Piantadosi, Werner Poewe, David Robertson, Cyndi Roemer, Dale Schenk, Michael Schlossmacher, Jeremy D Schmahmann, Klaus Seppi, Lily Shih, Andrew Siderowf, Glenn T Stebbins, Nadia Stefanova, Shoji Tsuji, Sharon Sutton, Jing Zhang
Multiple system atrophy (MSA) is a rare neurodegenerative disorder with substantial knowledge gaps despite recent gains in basic and clinical research. In order to make further advances, concerted international collaboration is vital. In 2014, an international meeting involving leaders in the field and MSA advocacy groups was convened in Las Vegas, Nevada, to identify critical research areas where consensus and progress was needed to improve understanding, diagnosis, and treatment of the disease. Eight topic areas were defined: pathogenesis, preclinical modeling, target identification, endophenotyping, clinical measures, imaging biomarkers, nonimaging biomarkers, treatments/trial designs, and patient advocacy...
January 9, 2018: Neurology
https://www.readbyqxmd.com/read/29225927/institutionalising-health-technology-assessment-establishing-the-medical-technology-assessment-board-in-india
#8
REVIEW
Laura E Downey, Abha Mehndiratta, Ashoo Grover, Vijay Gauba, Kabir Sheikh, Shankar Prinja, Ravinder Singh, Francoise A Cluzeau, Saudamini Dabak, Yot Teerawattananon, Sanjiv Kumar, Soumya Swaminathan
India is at crossroads with a commitment by the government to universal health coverage (UHC), driving efficiency and tackling waste across the public healthcare sector. Health technology assessment (HTA) is an important policy reform that can assist policy-makers to tackle inequities and inefficiencies by improving the way in which health resources are allocated towards cost-effective, appropriate and feasible interventions. The equitable and efficient distribution of health budget resources, as well as timely uptake of good value technologies, are critical to strengthen the Indian healthcare system...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29216564/p27kip1-as-a-key-regulator-of-endometriosis
#9
REVIEW
G A Gonçalves
p27kip1 as a key regulator of endometriosis Gonçalves GA p27kip1 is a cyclin-dependent kinase (CDK) inhibitor whose specific late G1 destruction allows progression of the cell across the G1/S boundary. There is a direct relationship between low level of p27 and rapid proliferation occurring in several benign states and in many malignances. In the glandular cells of the normal endometrium, the level of p27kip1 is exceedingly low during the proliferative phase, whereas it is markedly increased during the secretory phase...
December 4, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29214975/home-based-health-promotion-for-older-people-with-mild-frailty-the-homehealth-intervention-development-and-feasibility-rct
#10
Kate Walters, Rachael Frost, Kalpa Kharicha, Christina Avgerinou, Benjamin Gardner, Federico Ricciardi, Rachael Hunter, Ann Liljas, Jill Manthorpe, Vari Drennan, John Wood, Claire Goodman, Ana Jovicic, Steve Iliffe
BACKGROUND: Mild frailty or pre-frailty is common and yet is potentially reversible. Preventing progression to worsening frailty may benefit individuals and lower health/social care costs. However, we know little about effective approaches to preventing frailty progression. OBJECTIVES: (1) To develop an evidence- and theory-based home-based health promotion intervention for older people with mild frailty. (2) To assess feasibility, costs and acceptability of (i) the intervention and (ii) a full-scale clinical effectiveness and cost-effectiveness randomised controlled trial (RCT)...
December 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29206358/implementing-and-evaluating-early-intervention-for-children-with-autism-where-are-the-gaps-and-what-should-we-do
#11
Giacomo Vivanti, Connie Kasari, Jonathan Green, David Mandell, Melissa Maye, Kristelle Hudry
Despite recent advances, the evidence base supporting early intervention for young children with autism spectrum disorder (ASD) remains relatively sparse. The International Society for Autism Research (INSAR) recently sponsored a Special Interest Group (SIG) on Implementing and Evaluating Community-Based Early Intervention. Across three meetings, in 2015, 2016, and 2017, conveners of this SIG engaged >200 members to identify knowledge gaps and research priorities for moving the field forward. Here, we summarize the perspectives that emerged from group discussion at the SIG meetings as represented by scholars working actively in the field...
December 5, 2017: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/29202872/patterns-of-hiv-testing-drug-use-and-sexual-behaviors-in-people-who-use-drugs-findings-from-a-community-based-outreach-program-in-phnom-penh-cambodia
#12
Gitau Mburu, Chanrith Ngin, Sovannary Tuot, Pheak Chhoun, Khuondyla Pal, Siyan Yi
BACKGROUND: People who use drugs are an important priority for HIV programs. However, data related to their utilization of HIV services are limited. This paper reports patterns of HIV testing, drug use, and risk and service perception among people who use drugs. Study participants were receiving HIV and harm reduction services from a community-based program in Phnom Penh, comprised of itinerant peer-led outreach and static drop-in centers. METHODS: This was a mixed-methods study conducted in 2014, comprising of a quantitative survey using a structured questionnaire, followed by two focus group discussions among a sub-sample of survey participants...
December 5, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/29201977/mixed-emotions-within-the-context-of-goal-pursuit
#13
Shannon T Mejía, Karen Hooker
Development in adulthood occurs through the process of setting and working toward goals. Emotions link experiences to goals and action, and as such are integral to goal setting, evaluation of goal progress, and goal pursuit. When viewed in the context of goals, the simultaneous experience of positive and negative or "mixed" emotions coheres with the complexity of goal pursuit within the context of competing demands in daily life. Mixed emotions may be experienced as uncertainty in which goal to prioritize, ambiguity in whether an event served or impeded goal progress, or poignancy in a bittersweet moment of recognizing the losses that accompany gains...
June 2017: Current Opinion in Behavioral Sciences
https://www.readbyqxmd.com/read/29198262/medical-missions-for-the-provision-of-paediatric-cardiac-surgery-in-low-and-middle-income-countries
#14
Frank J Molloy, Nguyenvu Nguyen, Marisa Mize, Gavin Wright, Cecilia St George-Hyslop, Maura O'Callaghan, Emma Scanlan, William M Novick
This review will outline the role of visiting cardiac surgical teams in low- and middle-income countries drawing on the collective experience of the authors in a wide range of locations. Requests for assistance can emerge from local programmes at a beginner or advanced stage. However, in all circumstances, careful pre-trip planning is necessary in conjunction with clinical and non-clinical local partners. The clinical evaluation, surgical procedures, and postoperative care all serve as a template for collaboration and education between the visiting and local teams in every aspect of care...
December 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29196435/leaving-the-bench-and-finding-your-foundation
#15
REVIEW
John E Spiro
Scientists who leave the laboratory bench to work for biomedical foundations mobilize and focus resources on the most promising research behind a foundation's mission. They acquire a broad view of a field, interact closely with research scientists at meetings and laboratory visits, and often manage proposal review boards and monitor grant progress. Increasingly, scientists at foundations also have a more active role in catalyzing research: They are involved in organizing targeted workshops, setting research priorities, and directly creating and managing resources for a scientific community...
December 1, 2017: Cold Spring Harbor Perspectives in Biology
https://www.readbyqxmd.com/read/29161896/qualitative-analysis-of-infant-safe-sleep-public-campaign-messaging
#16
Nadine R Peacock, Susan Altfeld, Allison L Rosenthal, Caitlin E Garland, Jill M Massino, Sherri L Smith, Hillary L Rowe, Sarah E Wagener
The 1994 Back to Sleep public education campaign resulted in dramatic reductions in sleep-related infant deaths, but comparable progress in recent years has been elusive. We conducted qualitative analyses of recent safe sleep campaigns from 13 U.S. cities. Goals were to (a) determine whether the campaigns reflect the full range of American Academy of Pediatrics (AAP) 2011 safe sleep recommendations, (b) describe tone and framing of the messages (e.g., use of fear appeals), (c) describe targeting/tailoring of messages to priority populations, and (d) ascertain whether the campaigns have been evaluated for reach and/or effectiveness...
March 1, 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/29139220/creating-and-facilitating-change-for-person-centred-coordinated-care-p3c-the-development-of-the-organisational-change-tool-p3c-oct
#17
Jane Horrell, Helen Lloyd, Thavapriya Sugavanam, James Close, Richard Byng
BACKGROUND: Person Centred Coordinated Care (P3C) is a UK priority for patients, carers, professionals, commissioners and policy makers. Services are developing a range of approaches to deliver this care with a lack of tools to guide implementation. METHODOLOGY: A scoping review and critical examination of current policy, key literature and NHS guidelines, together with stakeholder involvement led to the identification of domains, subdomains and component activities (processes and behaviours) required to deliver P3C...
November 15, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/29117955/alzheimer-s-disease-related-dementias-summit-2016-national-research-priorities
#18
REVIEW
Roderick A Corriveau, Walter J Koroshetz, Jordan T Gladman, Sophia Jeon, Debra Babcock, David A Bennett, S Thomas Carmichael, Susan L-J Dickinson, Dennis W Dickson, Marian Emr, Howard Fillit, Steven M Greenberg, Michael L Hutton, David S Knopman, Jennifer J Manly, Karen S Marder, Claudia S Moy, Creighton H Phelps, Paul A Scott, William W Seeley, Beth-Anne Sieber, Nina B Silverberg, Margaret L Sutherland, Angela Taylor, Christine L Torborg, Salina P Waddy, Amelie K Gubitz, David M Holtzman
Goal 1 of the National Plan to Address Alzheimer's Disease is to prevent and effectively treat Alzheimer disease and Alzheimer disease-related dementias by 2025. To help inform the research agenda toward achieving this goal, the NIH hosts periodic summits that set and refine relevant research priorities for the subsequent 5 to 10 years. This proceedings article summarizes the 2016 Alzheimer's Disease-Related Dementias Summit, including discussion of scientific progress, challenges, and opportunities in major areas of dementia research, including mixed-etiology dementias, Lewy body dementia, frontotemporal degeneration, vascular contributions to cognitive impairment and dementia, dementia disparities, and dementia nomenclature...
December 5, 2017: Neurology
https://www.readbyqxmd.com/read/29095809/progress-in-childhood-vaccination-data-in-immunization-information-systems-united-states-2013-2016
#19
Neil Murthy, Loren Rodgers, Laura Pabst, Amy Parker Fiebelkorn, Terence Ng
In 2016, 55 jurisdictions in 49 states and six cities in the United States* used immunization information systems (IISs) to collect and manage immunization data and support vaccination providers and immunization programs. To monitor progress toward achieving IIS program goals, CDC surveys jurisdictions through an annual self-administered IIS Annual Report (IISAR). Data from the 2013-2016 IISARs were analyzed to assess progress made in four priority areas: 1) data completeness, 2) bidirectional exchange of data with electronic health record systems, 3) clinical decision support for immunizations, and 4) ability to generate childhood vaccination coverage estimates...
November 3, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29092057/health-system-dynamics-analysis-of-eyecare-services-in-trinidad-and-tobago-and-progress-towards-vision-2020-goals
#20
Tasanee Braithwaite, Blaine Winford, Henry Bailey, Petra Bridgemohan, Debra Bartholomew, Deo Singh, Subash Sharma, Rishi Sharma, Juan Carlos Silva, Alastair Gray, Samuel S Ramsewak, Rupert R A Bourne
Avoidable blindness is an important global public health concern. This study aimed to assess Trinidad and Tobago's progress towards achieving the Pan American Health Organization, 'Strategic Framework for Vision 2020: The Right to Sight-Caribbean Region,' indicators through comprehensive review of the eyecare system, in order to facilitate health system priority setting. We administered structured surveys to six stakeholder groups, including eyecare providers, patients and older adult participants in the National Eye Survey of Trinidad and Tobago...
October 30, 2017: Health Policy and Planning
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