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https://www.readbyqxmd.com/read/29353443/role-of-fluorescent-in-situ-hybridization-cholangioscopic-biopsies-and-eus-fna-in-the-evaluation-of-biliary-strictures
#1
Christian Brooks, Valerie Gausman, Chanthel Kokoy-Mondragon, Khushboo Munot, Sunil P Amin, Amit Desai, Claudine Kipp, John Poneros, Amrita Sethi, Frank G Gress, Michel Kahaleh, Vundavalli V Murty, Reem Sharaiha, Tamas A Gonda
BACKGROUND AND AIMS: Our goal was to compare the diagnostic accuracy of FISH in the detection of malignancy compared with other standard diagnostic modalities, including brush cytology and biopsy specimens over a 10-year period of prospective data collection. METHODS: We conducted a review of all consecutive biliary strictures evaluated between 2006 and 2016. Patients with a final pathologic diagnosis or conclusive follow-up were included. We evaluated the performance of FISH polysomy (CEP 3, 7, and 17) and 9p21 deletion as well as cholangioscopic biopsy (CBx) and EUS-FNA...
January 20, 2018: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29353246/a-concept-mapping-approach-to-identifying-the-barriers-to-implementing-an-evidence-based-sports-injury-prevention-programme
#2
Alex Donaldson, Aisling Callaghan, Mario Bizzini, Andrew Jowett, Patrick Keyzer, Matthew Nicholson
BACKGROUND AND AIM: Understanding the barriers to programme use is important to facilitate implementation of injury prevention programmes in real-word settings. This study investigated the barriers to coaches of adolescent female soccer teams, in Victoria, Australia, implementing the evidence-based FIFA 11+ injury prevention programme. METHODS: Concept mapping with data collected from 19 soccer coaches and administrators. RESULTS: Brainstorming generated 65 statements as barriers to 11+ implementation...
January 20, 2018: Injury Prevention: Journal of the International Society for Child and Adolescent Injury Prevention
https://www.readbyqxmd.com/read/29353103/taking-the-heat-or-taking-the-temperature-a-qualitative-study-of-a-large-scale-exercise-in-seeking-to-measure-for-improvement-not-blame
#3
Natalie Armstrong, Liz Brewster, Carolyn Tarrant, Ruth Dixon, Janet Willars, Maxine Power, Mary Dixon-Woods
Measurement of quality and safety has an important role in improving healthcare, but is susceptible to unintended consequences. One frequently made argument is that optimising the benefits from measurement requires controlling the risks of blame, but whether it is possible to do this remains unclear. We examined responses to a programme known as the NHS Safety Thermometer (NHS-ST). Measuring four common patient harms in diverse care settings with the goal of supporting local improvement, the programme explicitly eschews a role for blame...
January 2, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29352708/a-systematic-review-and-discussion-of-symptom-specific-cognitive-behavioural-approaches-to-delusions-and-hallucinations
#4
Tania M Lincoln, Emmanuelle Peters
Studies on cognitive behavioural therapy for psychosis (CBTp) have developed from evaluating generic approaches to focusing on specific symptoms. The evidence for targeted studies on delusions and hallucinations was reviewed. We included randomized controlled trials (RCTs) examining the effect of individualized CBT-based interventions focusing either on delusions or on hallucinations. Twelve suitable RCTs were identified. Four RCTs focused on delusions, of which three took a focused approach targeting mechanisms assumed causal to persecutory delusions...
January 16, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29352662/distinct-progression-patterns-of-brain-disease-in-infantile-and-juvenile-gangliosidoses-volumetric-quantitative-mri-study
#5
Igor Nestrasil, Alia Ahmed, Josephine M Utz, Kyle Rudser, Chester B Whitley, Jeanine R Jarnes-Utz
BACKGROUND: GM1-gangliosidosis and GM2-gangliosidosis (Tay-Sachs disease and Sandhoff disease) are unrelenting heritable neurodegenerative conditions of lysosomal ganglioside accumulation. Although progressive brain atrophy is characteristic, longitudinal quantification of specific brain structures has not been systematically studied. OBJECTIVES: The goal of this longitudinal study has been to quantify and track brain MRI volume changes, including specific structure volume changes, at different times in disease progression of childhood gangliosidoses, and to explore quantitative brain MRI volumetry (qMRI) as a non-invasive marker of disease progression for future treatment trials...
December 20, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/29352525/an-mrm-based-cytokeratin-marker-assay-as-a-tool-for-cancer-studies-application-to-lung-cancer-pleural-effusions
#6
Anna Perzanowska, Agnieszka Fatalska, Grzegorz Wojtas, Andrzej Lewandowicz, Agata Michalak, Grzegorz Krasowski, Christoph H Borchers, Michal Dadlez, Dominik Domanski
PURPOSE: The goal of this work was to develop an LC-MRM assay for the quantitative analysis of a set of established and diagnostically important cytokeratin (CK) markers used in cancer diagnosis, prognosis and therapy monitoring. Secondly, the potential of this assay in lung cancer diagnosis through pleural effusion (PE) analysis was examined. EXPERIMENTAL DESIGN: A multiplexed MRM assay was developed for 17 CKs and their select caspase-cleaved fragments. Isotope-labeled standard peptides were used for high assay specificity and absolute peptide quantitation; with robust standard-flow LC coupled to a latest-generation triple-quadrupole instrument for high sensitivity...
January 19, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29352082/clostridial-strain-specific-characteristics-associated-with-necrotizing-enterocolitis
#7
Sophia Schönherr-Hellec, Geraldine L Klein, Johanne Delannoy, Laurent Ferraris, Jean Christophe Rozé, Marie José Butel, Julio Aires
We aimed at identifying potential clostridial factors linking these bacteria with necrotizing enterocolitis (NEC). We compared the phenotypic traits, stress responses, cellular cytotoxicity and inflammatory capabilities of the largest collection of Clostridium butyricum and Clostridium neonatale strains isolated from fecal samples of NEC and control preterm neonates (PN). When strains characteristics were used as explanatory variables, a statistical discriminant analysis allowed the separation of NEC and control strains into separate groups...
January 19, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29351906/edc-impact-molecular-effects-of-developmental-fm-550-exposure-in-wistar-rat-placenta-and-fetal-forebrain
#8
Kylie R Baldwin, Brian Horman, Allison L Phillips, Susan L McRitchie, Scott Watson, Jocelin Deese-Spruill, Dereje Jima, Susan Sumner, Heather Stapleton, Heather Patisaul
Firemaster 550 (FM 550) is a flame retardant (FR) mixture that has become one of the most commonly used FRs in foam-based furniture and baby products. Human exposure to this commercial mixture, comprised of brominated and organophosphate components, is widespread. We have repeatedly shown that developmental exposure can lead to sex-specific behavioral effects in rats. Accruing evidence of endocrine disruption and potential neurotoxicity have raised concerns regarding the neurodevelopmental effects of FM 550 exposure, but the specific mechanisms of action remains unclear...
January 19, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29351711/-beck-anxiety-inventory-german-version-a-reliable-valid-patientfriendly-instrument-for-measuring-clinical-anxiety
#9
Edgar Geissner, Anne Huetteroth
The Beck Anxiety Inventory (BAI) is available in German. Apart from data in its manual, there are no further reports on the psychometric properties of this questionnaire and on its suitability for clinical use in Germany. This study therefore offers an independent investigation into the psychometrics as well as the clinical characteristics of the BAI. Three samples with n=145, n=90, and n=174 comprised inpatients diagnosed with anxiety disorders and treated in a large psychosomatic hospital. In addition to the BAI, the clinician rating Hamilton Anxiety Scale (HamA), the State-Trait-Anxiety Inventory (STAI) as well as the two anxiety subscales of the Symptom Checklist 90 (SCL 90) were used to establish convergent validity...
January 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/29351607/sector-wide-or-disease-specific-implications-of-trends-in-development-assistance-for-health-for-the-sdg-era
#10
Anne L Buffardi
The record of the Millennium Development Goals broadly reflects the trade-offs of disease-specific financing: substantial progress in particular areas, facilitated by time-bound targets that are easy to measure and communicate, which shifted attention and resources away from other areas, masked inequalities and exacerbated fragmentation. In many ways, the Sustainable Development Goals reflect a profound shift towards a more holistic, system-wide approach. To inform responses to this shift, this article builds upon existing work on aggregate trends in donor financing, bringing together what have largely been disparate analyses of sector-wide and disease-specific financing approaches...
January 16, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29350078/external-control-of-knowledge-of-results-learner-involvement-enhances-motor-skill-transfer
#11
L S Figueiredo, H Ugrinowitsch, A B Freire, J B Shea, R N Benda
Providing the learner control over aspects of practice has improved the process of motor skill acquisition, and self-controlled knowledge of results (KR) schedules have shown specific advantages over externally controlled ones. A possible explanation is that self-controlled KR schedules lead learners to more active task involvement, permitting deeper information processing. This study tested this explanatory hypothesis. Thirty undergraduate volunteers of both sexes, aged 18 to 35, all novices in the task, practiced transporting a tennis ball in a specified sequence within a time goal...
January 1, 2018: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/29349544/interpretation-of-motion-analysis-of-laparoscopic-instruments-based-on-principal-component-analysis-in-box-trainer-settings
#12
Ignacio Oropesa, Fernando Pérez Escamirosa, Juan A Sánchez-Margallo, Silvia Enciso, Borja Rodríguez-Vila, Arturo Minor Martínez, Francisco M Sánchez-Margallo, Enrique J Gómez, Patricia Sánchez-González
BACKGROUND: Motion analysis parameters (MAPs) have been extensively validated for assessment of minimally invasive surgical skills. However, there are discrepancies on how specific MAPs, tasks, and skills match with each other, reflecting that motion analysis cannot be generalized independently of the learning outcomes of a task. Additionally, there is a lack of knowledge on the meaning of motion analysis in terms of surgical skills, making difficult the provision of meaningful, didactic feedback...
January 18, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29348321/lower-limbic-metabotropic-glutamate-receptor-5-availability-in-alcohol-dependence
#13
Gil Leurquin-Sterk, Jenny Ceccarini, Cleo L Crunelle, Bart de Laat, Jef Verbeek, Stephanie Deman, Hugo Neels, Guy Bormans, Hendrik Peuskens, Koen Van Laere
Animal studies suggest an important role for the metabotropic glutamate receptor subtype 5 (mGlu5) in the pathophysiology of alcohol dependence, but direct human evidence is lacking. The goal of this study was to investigate cerebral mGlu5 availability in alcohol-dependent patients versus controls using 18F-FPEB positron emission tomography. Methods: Dynamic 90 minute 18F-FPEB scans combined with arterial blood sampling were acquired in 16 recently abstinent alcohol-dependent patients and 32 age-matched controls...
January 18, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29348166/clinical-evaluation-of-a-blood-assay-to-diagnose-paucibacillary-tuberculosis-via-bacterial-antigens
#14
Chang Liu, Christopher J Lyon, Yang Bu, Zaian Deng, Elisabetta Walters, Yan Li, Liqun Zhang, Anneke C Hesseling, Edward A Graviss, Ye Hu
BACKGROUND: The diagnosis of active tuberculosis (TB)10 cases primarily relies on methods that detect Mycobacterium tuberculosis (Mtb) bacilli or their DNA in patient samples (e.g., mycobacterial culture and Xpert MTB/RIF assays), but these tests have low clinical sensitivity for patients with paucibacillary TB disease. Our goal was to evaluate the clinical performance of a newly developed assay that can rapidly diagnose active TB cases by direct detection of Mtb-derived antigens in patients' blood samples...
January 18, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29347942/infant-and-child-mortality-in-relation-to-malaria-transmission-in-kemri-cdc-hdss-western-kenya-validation-of-verbal-autopsy
#15
Nyaguara O Amek, Annemieke Van Eijk, Kim A Lindblade, Mary Hamel, Nabie Bayoh, John Gimnig, Kayla F Laserson, Laurence Slutsker, Thomas Smith, Penelope Vounatsou
BACKGROUND: Malaria transmission reduction is a goal of many malaria control programmes. Little is known of how much mortality can be reduced by specific reductions in transmission. Verbal autopsy (VA) is widely used for estimating malaria specific mortality rates, but does not reliably distinguish malaria from other febrile illnesses. Overall malaria attributable mortality includes both direct and indirect deaths. It is unclear what proportion of the deaths averted by reducing malaria transmission are classified as malaria in VA...
January 18, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29347549/multiscale-permutation-entropy-analysis-of-laser-beam-wandering-in-isotropic-turbulence
#16
Felipe Olivares, Luciano Zunino, Damián Gulich, Darío G Pérez, Osvaldo A Rosso
We have experimentally quantified the temporal structural diversity from the coordinate fluctuations of a laser beam propagating through isotropic optical turbulence. The main focus here is on the characterization of the long-range correlations in the wandering of a thin Gaussian laser beam over a screen after propagating through a turbulent medium. To fulfill this goal, a laboratory-controlled experiment was conducted in which coordinate fluctuations of the laser beam were recorded at a sufficiently high sampling rate for a wide range of turbulent conditions...
October 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346375/how-do-we-reach-the-girls-and-women-who-are-the-hardest-to-reach-inequitable-opportunities-in-reproductive-and-maternal-health-care-services-in-armed-conflict-and-forced-displacement-settings-in-colombia
#17
Juan Carlos Rivillas, Raul Devia Rodriguez, Gloria Song, Andréanne Martel
OBJECTIVES: This paper assesses inequalities in access to reproductive and maternal health services among females affected by forced displacement and sexual and gender-based violence in conflict settings in Colombia. This was accomplished through the following approaches: first, we assessed the gaps and gradients in three selected reproductive and maternal health care services. Second, we analyzed the patterns of inequalities in reproductive and maternal health care services and changes over time...
2018: PloS One
https://www.readbyqxmd.com/read/29346214/validation-of-biomarkers-for-early-detection-of-pancreatic-cancer-summary-of-the-alliance-of-pancreatic-cancer-consortia-for-biomarkers-for-early-detection-workshop
#18
Matthew R Young, Paul D Wagner, Sharmistha Ghosh, Jo Ann Rinaudo, Stuart G Baker, Kenneth S Zaret, Michael Goggins, Sudhir Srivastava
Pancreatic cancer is the third leading cause of cancer death in the United States, and the 5-year relative survival for patients diagnosed with pancreatic cancer is less than 10%. Early intervention is the key to a better survival outcome. Currently, there are no biomarkers that can reliably detect pancreatic cancer at an early stage or identify precursors that are destined to progress to malignancy. The National Cancer Institute in partnership with the Kenner Family Research Fund and the Pancreatic Cancer Action Network convened a Data Jamboree on Biomarkers workshop on December 5, 2016, to discuss and evaluate existing or newly developed biomarkers and imaging methods for early detection of pancreatic cancer...
February 2018: Pancreas
https://www.readbyqxmd.com/read/29346102/impedance-measures-during-in-vitro-cochlear-implantation-predict-array-positioning
#19
Christopher Kenneth Giardina, Elliot Samuel Krause, Kanthaiah Koka, Douglas Carl Fitzpatrick
OBJECTIVE: Improper electrode placement during cochlear implant (CI) insertion can adversely affect speech perception outcomes. However, the intraoperative methods to determine positioning are limited. Because measures of electrode impedance can be made quickly, the goal of this study was to assess the relationship between CI impedance and proximity to adjacent structures. METHODS: An Advanced Bionics CI array was inserted into a clear, plastic cochlea one electrode contact at a time in a saline bath (nine trials)...
February 2018: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/29345987/habitable-worlds-delivering-on-the-promises-of-online-education
#20
Lev B Horodyskyj, Chris Mead, Zack Belinson, Sanlyn Buxner, Steven Semken, Ariel D Anbar
Critical thinking and scientific reasoning are central to higher education in the United States, but many courses (in-person and online) teach students information about science much more than they teach the actual process of science and its associated knowledge and skills. In the online arena specifically, the tools available for course construction exacerbate this problem by making it difficult to build the types of active learning activities that research shows to be the most effective. Here, we present a report on Habitable Worlds, offered by Arizona State University for 12 semesters over the past 6 years...
January 2018: Astrobiology
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