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https://www.readbyqxmd.com/read/28944453/personalised-digital-interventions-for-reducing-hazardous-and-harmful-alcohol-consumption-in-community-dwelling-populations
#1
REVIEW
Eileen Fs Kaner, Fiona R Beyer, Claire Garnett, David Crane, Jamie Brown, Colin Muirhead, James Redmore, Amy O'Donnell, James J Newham, Frank de Vocht, Matthew Hickman, Heather Brown, Gregory Maniatopoulos, Susan Michie
BACKGROUND: Excessive alcohol use contributes significantly to physical and psychological illness, injury and death, and a wide array of social harm in all age groups. A proven strategy for reducing excessive alcohol consumption levels is to offer a brief conversation-based intervention in primary care settings, but more recent technological innovations have enabled people to interact directly via computer, mobile device or smartphone with digital interventions designed to address problem alcohol consumption...
September 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28944450/review-dynamic-spatial-models-of-parasite-transmission-in-wildlife-their-structure-applications-and-remaining-challenges
#2
REVIEW
L A White, J D Forester, M E Craft
1.Individual differences in contact rate can arise from host, group, and landscape heterogeneity and can result in different patterns of spatial spread for diseases in wildlife populations with concomitant implications for disease control in wildlife of conservation concern, livestock, and humans. While dynamic disease models can provide a better understanding of the drivers of spatial spread, the effects of landscape heterogeneity have only been modelled in a few well-studied wildlife systems such as rabies and bovine tuberculosis...
September 25, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28944316/relationship-between-anti-depressant-use-and-lung-cancer-survival
#3
Adriana Zingone, Derek Brown, Elise D Bowman, Oscar Vidal, Julien Sage, Joel Neal, Bríd M Ryan
OBJECTIVES: In recent years, the anti-cancer properties of several commonly used drugs have been explored, with drugs such as aspirin and beta-blockers associated with improved cancer outcomes. Previous preclinical work demonstrated that tricyclic anti-depressants have antitumor efficacy in lung cancer. Our goal was to examine the association between anti-depressant use and survival in lung cancer. MATERIALS AND METHODS: We examined the association between use of common anti-depressants and survival in 1,097 lung cancer patients from the NCI-Maryland lung cancer study...
2017: Cancer Treat Res Commun
https://www.readbyqxmd.com/read/28944028/the-underestimated-role-of-temperature-oxygen-relationship-in-large-scale-studies-on-size-to-temperature-response
#4
Aleksandra Walczyńska, Łukasz Sobczyk
The observation that ectotherm size decreases with increasing temperature (temperature-size rule; TSR) has been widely supported. This phenomenon intrigues researchers because neither its adaptive role nor the conditions under which it is realized are well defined. In light of recent theoretical and empirical studies, oxygen availability is an important candidate for understanding the adaptive role behind TSR. However, this hypothesis is still undervalued in TSR studies at the geographical level. We reanalyzed previously published data about the TSR pattern in diatoms sampled from Icelandic geothermal streams, which concluded that diatoms were an exception to the TSR...
September 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28943974/relationships-between-self-perceptions-and-physical-activity-behaviour-fear-of-falling-and-physical-function-among-older-adults
#5
Myrla Sales, Pazit Levinger, Remco Polman
BACKGROUND: There has been a lack of research examining the relationship among self-perceptions, behaviour, cognitions and functioning in older adults. This study, therefore, examined the relationship between global and physical self-perceptions, physical activity behaviour, and fear of falling taking into considerations objective measures of physical functioning in community dwelling older adults. METHODS/DESIGN: Sixty-six participants between 60 and 90 years old (71...
2017: European Review of Aging and Physical Activity
https://www.readbyqxmd.com/read/28943753/grateful-parents-raising-grateful-children-niche-selection-and-the-socialization-of-child-gratitude
#6
William A Rothenberg, Andrea M Hussong, Hillary A Langley, Gregory A Egerton, Amy G Halberstadt, Jennifer L Coffman, Irina Mokrova, Philip R Costanzo
Given that children's exposure to gratitude-related activities may be one way that parents can socialize gratitude in their children, we examined whether parents' niche selection (i.e., tendency to choose perceived gratitude-inducing activities for their children) mediates the association between parents' reports of their own and their children's gratitude. Parent-child dyads (N =101; children aged 6-9; 52% girls; 80% Caucasian; 85% mothers) participated in a laboratory visit and parents also completed a seven-day online diary regarding children's gratitude...
2017: Applied Developmental Science
https://www.readbyqxmd.com/read/28943742/academic-procrastination-and-goal-accomplishment-a-combined-experimental-and-individual-differences-investigation
#7
Daniel E Gustavson, Akira Miyake
This study examined the relationship between academic procrastination and goal accomplishment in two novel ways. First, we experimentally tested whether undergraduate students (N = 177) could reduce their academic procrastination over a course of three weeks after performing goal-related exercises to set so-called SMART goals and/or to prepare those students with specific strategies to resist their temptations (forming implementation intentions). Second, we conducted systematic regression analyses to examine whether academic procrastination at baseline uniquely predicts later goal-related outcomes, controlling for various correlated variables, including personality traits (e...
February 2017: Learning and Individual Differences
https://www.readbyqxmd.com/read/28942925/deconstruction-of-corticospinal-circuits-for-goal-directed-motor-skills
#8
Xuhua Wang, Yuanyuan Liu, Xinjian Li, Zicong Zhang, Hengfu Yang, Yu Zhang, Philip R Williams, Noaf S A Alwahab, Kush Kapur, Bin Yu, Yiming Zhang, Mengying Chen, Haixia Ding, Charles R Gerfen, Kuan Hong Wang, Zhigang He
Corticospinal neurons (CSNs) represent the direct cortical outputs to the spinal cord and play important roles in motor control across different species. However, their organizational principle remains unclear. By using a retrograde labeling system, we defined the requirement of CSNs in the execution of a skilled forelimb food-pellet retrieval task in mice. In vivo imaging of CSN activity during performance revealed the sequential activation of topographically ordered functional ensembles with moderate local mixing...
September 20, 2017: Cell
https://www.readbyqxmd.com/read/28942904/a-brief-historical-perspective-of-cancer-rehabilitation-and-contributions-from-the-national-institutes-of-health
#9
REVIEW
Lynn H Gerber, Bonnie Hodsdon, Leora Ellen Comis, Leighton Chan, John I Gallin, Charles L McGarvey
People who have cancer diagnoses often need care throughout their lives through all stages of their illness. These stages include diagnosis, primary treatment, survivorship, and end of life. The management of people with cancer, now a common and chronic illness with long-term survival improving, is complex, challenging, and rapidly changing. Rehabilitation for people with cancer diagnoses is a new specialty and is charged with providing care throughout the trajectory of illness and wellness to maximize potential for function and mitigate disability...
September 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28942512/altered-endothelial-nitric-oxide-signaling-as-a-paradigm-for-maternal-vascular-maladaptation-in-preeclampsia
#10
REVIEW
George Osol, Nga Ling Ko, Maurizio Mandalà
PURPOSE OF REVIEW: The goal of this review is to present the newest insights into what we view as a central failure of cardiovascular adaptation in preeclampsia (PE) by focusing on one clinically significant manifestation of maternal endothelial dysfunction: nitric oxide signaling. The etiology, symptoms, and current theories of the PE syndrome are described first, followed by a review of the available evidence, and underlying causes of reduced endothelial nitric oxide (NO) signaling in PE...
September 23, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/28942494/working-with-the-hmong-population-in-a-genetics-setting-an-interpreter-perspective
#11
Meghan Krieger, Aime Agather, Kathryn Douglass, Catherine A Reiser, Elizabeth M Petty
The aim of this pilot qualitative study was to describe the experiences and beliefs of medical interpreters when working with genetic counselors and other genetic providers caring for Hmong patients who are not native English speakers. Specific goals were to identify interpreters' thoughts and perceptions on (a) their roles during sessions, (b) unique challenges in a genetics session, (c) knowledge genetics providers need when working with Hmong patients and interpreters, and (d) supports and training needed to effectively interpret in a genetics setting...
September 24, 2017: Journal of Genetic Counseling
https://www.readbyqxmd.com/read/28942481/high-resolution-vessel-wall-mri-for-the-evaluation-of-intracranial-atherosclerotic-disease
#12
REVIEW
Adam de Havenon, Mahmud Mossa-Basha, Lubdha Shah, Seong-Eun Kim, Min Park, Dennis Parker, J Scott McNally
High-resolution vessel wall MRI (vwMRI) of the intracranial arteries is an emerging diagnostic imaging technique with the goal of evaluating vascular pathology. vwMRI sequences have high spatial resolution and directly image the vessel wall by suppressing blood signal. With vwMRI, it is possible to identify distinct morphologic and enhancement patterns of atherosclerosis that can provide important information about stroke etiology and recurrence risk. We present a review of vwMRI research in relation to intracranial atherosclerosis, with a focus on the relationship between ischemic stroke and atherosclerotic plaque T1 post-contrast enhancement or plaque/vessel wall morphology...
September 23, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28942090/improving-risk-equalization-for-individuals-with-persistently-high-costs-experiences-from-the-netherlands
#13
Frank Eijkenaar, René C J A van Vliet
BACKGROUND: Risk-equalization (RE) models in competitive health insurance markets have become increasingly sophisticated. However, these models still have important imperfections. A specific problem in the Netherlands is that insurers are insufficiently compensated for individuals who can persistently be found in the right-end tail of the cost distribution. OBJECTIVES: The goal of this study is to explore and evaluate options for improving compensation for persistently high-cost individuals in the Dutch basic health insurance...
September 14, 2017: Health Policy
https://www.readbyqxmd.com/read/28941568/resuscitation-thoracotomy
#14
G Boddaert, E Hornez, H De Lesquen, A Avramenko, B Grand, T MacBride, J-P Avaro
Resuscitation thoracotomy is a rarely performed procedure whose use, in France, remains marginal. It has five specific goals that correspond point-by-point to the causes of traumatic cardiac arrest: decompression of pericardial tamponade, control of cardiac hemorrhage, performance of internal cardiac massage, cross-clamping of the descending thoracic aorta, and control of lung injuries and other intra-thoracic hemorrhage. This approach is part of an overall Damage Control strategy, with a targeted operating time of less than 60minutes...
September 20, 2017: Journal of Visceral Surgery
https://www.readbyqxmd.com/read/28941283/intracellular-response-to-process-optimization-and-impact-on-productivity-and-product-aggregates-for-a-high-titer-cho-cell-process
#15
Michael W Handlogten, Allison Lee-O'Brien, Gargi Roy, Sophia V Levitskaya, Raghavan Venkat, Shailendra Singh, Sanjeev Ahuja
A key goal in process development for antibodies is to increase productivity while maintaining or improving product quality. During process development of an antibody, titers were increased from 4 to 10 g/L while simultaneously decreasing aggregates. Process development involved optimization of media and feed formulations, feed strategy, and process parameters including pH and temperature. To better understand how CHO cells respond to process changes, the changes were implemented in a stepwise manner. The first change was an optimization of the feed formulation, the second was an optimization of the medium, and the third was an optimization of process parameters...
September 23, 2017: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/28941142/coordination-accelerated-iron-extraction-enables-fast-biodegradation-of-mesoporous-silica-based-hollow-nanoparticles
#16
Liying Wang, Minfeng Huo, Yu Chen, Jianlin Shi
Biodegradation behavior of inorganic silica-based nanoplatforms is of critical importance in their clinical translations, but still remains a great challenge in achieving this goal by composition regulation of biocompatible silica framework. In the present work, a chemical coordination-accelerated biodegradation strategy to endow hollow mesoporous silica nanoparticles (HMSNs) with unique coordination-responsive biodegradability, on-demand coordination-responsive drug releasing behavior, and significantly enhanced chemotherapeutic efficacy by directly doping iron (Fe) ions into the framework of mesoporous silica is reported...
September 21, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28940536/patient-value-perspectives-from-the-advocacy-community
#17
REVIEW
Bonnie J Addario, Ana Fadich, Jesme Fox, Linda Krebs, Deborah Maskens, Kathy Oliver, Erin Schwartz, Gilliosa Spurrier-Bernard, Timothy Turnham
All health-care systems are under financial pressure and many have therefore developed value frameworks to assist decision making regarding access to treatment. Unfortunately, many frameworks simply reflect the clinically focused values held by health-care professionals rather than outcomes that also matter to patients. It is difficult to define one single homogeneous set of patient values as these are shaped by social, religious and cultural factors, and health-care environment, as well as many factors such as age, gender, education, family and friends and personal finances...
September 20, 2017: Health Expectations: An International Journal of Public Participation in Health Care and Health Policy
https://www.readbyqxmd.com/read/28940229/patient-participation-in-mental-health-care-perspectives-of-healthcare-professionals-an-integrative-review
#18
REVIEW
Kim Jørgensen, Jacob Dahl Rendtorff
BACKGROUND: In contemporary Western liberal society, patient participation has become a key goal in psychiatric healthcare treatment. Health professionals must encourage patients to play an active and involved part in their treatment. According to Danish health law, patients have the right to participate in their treatment, and the mental health system therefore needs to be reformed in order to ensure that treatment is based on individual, liberal, values. However, patient participation is not clearly defined, and it is therefore a challenge to transfer it to clinical practice...
September 22, 2017: Scandinavian Journal of Caring Sciences
https://www.readbyqxmd.com/read/28940053/the-influence-of-body-mass-index-sex-muscle-activation-on-pressure-distribution-during-lateral-falls-on-the-hip
#19
Steven P Pretty, Daniel R Martel, Andrew C Laing
Hip fracture incidence rates are influenced by body mass index (BMI) and sex, likely through mechanistic pathways that influence dynamics of the pelvis-femur system during fall-related impacts. The goal of this study was to extend our understanding of these impact dynamics by investigating the effects of BMI, sex, and local muscle activation on pressure distribution over the hip region during lateral impacts. Twenty participants underwent "pelvis-release experiments" (which simulate a lateral fall onto the hip), including muscle-'relaxed' and 'contracted' trials...
September 22, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28939804/separate-neural-representations-of-depression-anxiety-and-apathy-in-parkinson-s-disease
#20
Rotem Dan, Filip Růžička, Ondrej Bezdicek, Evžen Růžička, Jan Roth, Josef Vymazal, Gadi Goelman, Robert Jech
Depression, anxiety and apathy are distinct neuropsychiatric symptoms that highly overlap in Parkinson's disease (PD). It remains unknown whether each symptom is uniquely associated with a functional network dysfunction. Here, we examined whether individual differences in each neuropsychiatric symptom predict functional connectivity patterns in PD patients while controlling for all other symptoms and motor function. Resting-state functional connectivity MRI were acquired from 27 PD patients and 29 healthy controls...
September 22, 2017: Scientific Reports
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