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https://www.readbyqxmd.com/read/29458152/controversies-in-endoscopic-eradication-therapy-for-barrett-s-esophagus
#1
Srinadh Komanduri, V Raman Muthusamy, Sachin Wani
Advances in Endoscopic Eradication Therapy for Barrett's Esophagus associated neoplasia have resulted in a significant paradigm shift in diagnosis and management of this complex disease. A robust body of literature critically evaluating outcomes of resection and ablative strategies has allowed gastroenterologists to make quality, evidence based decisions for their patients. Despite this progress, there are still many unanswered questions and challenges that remain. Ultimately, identification of a cost-effective screening modality, biomarkers for risk stratification, and strides to eliminate post surveillance endoscopy after EET are essential to reach our long term goal for eradication of esophageal adenocarcinoma...
February 16, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29457126/using-predictive-evaluation-to-design-evaluate-and-improve-training-for-polio-volunteers
#2
Denise A Traicoff, Dave Basarab, Derek T Ehrhardt, Sandi Brown, Martin Celaya, Dennis Jarvis, Elizabeth H Howze
Background: Predictive Evaluation (PE) uses a four-step process to predict results then designs and evaluates a training intervention accordingly. In 2012, the Sustainable Management Development Program (SMDP) at the Centers for Disease Control and Prevention used PE to train Stop Transmission of Polio (STOP) program volunteers. Methods: Stakeholders defined specific beliefs and practices that volunteers should demonstrate. These predictions and adult learning practices were used to design a curriculum to train four cohorts...
March 2018: Pedagogy in Health Promotion
https://www.readbyqxmd.com/read/29456757/the-natural-history-of-spinal-deformity-in-patients-with-coffin-lowry-syndrome
#3
M Welborn, S Farrell, P Knott, E Mayekar, S Mardjetko
Purpose: Little is known about the natural history of spinal deformities in Coffin-Lowry syndrome (CLS). Our goal was to evaluate the spinal deformity progression and clinical impact. Methods: In this institutional review board-approved study, we performed a multinational retrospective review of six male CLS patients, aged 13 to 22 years at final follow-up, for a mean of 7.25 years (3 to 13). Results: All showed delayed skeletal maturity. Three had calcifications of their lower cervical ligamentum flavum, all experienced neural axis abnormalities, including lower extremity weakness, numbness and tingling and in one, quadriparesis...
February 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29456436/learning-activity-predictors-from-sensor-data-algorithms-evaluation-and-applications
#4
Bryan Minor, Janardhan Rao Doppa, Diane J Cook
Recent progress in Internet of Things (IoT) platforms has allowed us to collect large amounts of sensing data. However, there are significant challenges in converting this large-scale sensing data into decisions for real-world applications. Motivated by applications like health monitoring and intervention and home automation we consider a novel problem called Activity Prediction , where the goal is to predict future activity occurrence times from sensor data. In this paper, we make three main contributions...
December 1, 2017: IEEE Transactions on Knowledge and Data Engineering
https://www.readbyqxmd.com/read/29455160/children-and-adolescents-experiences-of-primary-lymphoedema-semistructured-interview-study
#5
Camilla S Hanson, Johanna Newsom, Davinder Singh-Grewal, Nicholas Henschke, Margaret Patterson, Allison Tong
BACKGROUND: Congenital lymphoedema is a lifelong condition that has detrimental physical and psychosocial outcomes for young patients and burdensome treatment responsibilities that may hamper patients' motivation for self-management. There is limited research from the perspective of young people with primary lymphoedema. We aimed to describe the experiences and views of children and adolescents with lymphoedema to inform patient-centred practice. METHODS: Twenty patients (aged 8-21 years) with primary lymphoedema were purposively sampled from two paediatric clinics in Sydney, Australia, to participate in a semistructured interview...
February 17, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29454549/technology-advances-to-improve-response-to-cardiac-resynchronization-therapy-what-clinicians-should-know
#6
Angelo Auricchio, Ward A Heggermont
Cardiac resynchronization therapy (CRT) is a well-established treatment for symptomatic heart failure patients with reduced left ventricular ejection fraction, prolonged QRS duration, and abnormal QRS morphology. The ultimate goals of modern CRT are to improve the proportion of patients responding to CRT and to maximize the response to CRT in patients who do respond. While the rate of CRT nonresponders has moderately but progressively decreased over the last 20 years, mostly in patients with left bundle branch block, in patients without left bundle branch block the response rate is almost unchanged...
February 14, 2018: Revista Española de Cardiología
https://www.readbyqxmd.com/read/29454519/high-resolution-age-structured-mapping-of-childhood-vaccination-coverage-in-low-and-middle-income-countries
#7
C Edson Utazi, Julia Thorley, Victor A Alegana, Matthew J Ferrari, Saki Takahashi, C Jessica E Metcalf, Justin Lessler, Andrew J Tatem
BACKGROUND: The expansion of childhood vaccination programs in low and middle income countries has been a substantial public health success story. Indicators of the performance of intervention programmes such as coverage levels and numbers covered are typically measured through national statistics or at the scale of large regions due to survey design, administrative convenience or operational limitations. These mask heterogeneities and 'coldspots' of low coverage that may allow diseases to persist, even if overall coverage is high...
February 14, 2018: Vaccine
https://www.readbyqxmd.com/read/29454392/soft-robotic-devices-for-hand-rehabilitation-and-assistance-a-narrative-review
#8
REVIEW
Chia-Ye Chu, Rita M Patterson
INTRODUCTION: The debilitating effects on hand function from a number of a neurologic disorders has given rise to the development of rehabilitative robotic devices aimed at restoring hand function in these patients. To combat the shortcomings of previous traditional robotics, soft robotics are rapidly emerging as an alternative due to their inherent safety, less complex designs, and increased potential for portability and efficacy. While several groups have begun designing devices, there are few devices that have progressed enough to provide clinical evidence of their design's therapeutic abilities...
February 17, 2018: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/29454295/synthetic-and-genetically-encoded-fluorescent-neural-activity-indicators
#9
REVIEW
Claire Deo, Luke D Lavis
The ultimate goal of neuroscience is to relate the complex activity of cells and cell-networks to behavior and cognition. This requires tools and techniques to visualize neuronal activity. Fluorescence microscopy is an ideal tool to measure activity of cells in the brain due to the high sensitivity of the technique and the growing portfolio of optical hardware and fluorescent sensors. Here, we give a chemist's perspective on the recent progress of fluorescent activity indicators that enable the measurement of cellular events in the living brain...
February 14, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29452663/management-of-untreated-advanced-stage-follicular-lymphoma-role-of-patient-discernment
#10
REVIEW
Jayadev Manikkam Umakanthan, Mathew A Lunning
Follicular lymphoma is the most common indolent non-Hodgkin lymphoma. Advanced stage disease is common at diagnosis. The timing of treatment for follicular lymphoma is best approached by considering the combination of presence or absence of symptoms along with estimation of tumor burden. Upfront treatment strategies should take into initial presentation variables, pace of disease progression and goals of care after discussion with the patient. Treatment approaches remain diverse and patient discernment is paramount...
March 2018: Best Practice & Research. Clinical Haematology
https://www.readbyqxmd.com/read/29451696/randomized-phase-2-trial-of-pemetrexed-pemetrexed-bevacizumab-and-pemetrexed-carboplatin-bevacizumab-in-patients-with-stage-iiib-iv-non-small-cell-lung-cancer-and-an-eastern-cooperative-oncology-group-performance-status-of-2
#11
David R Spigel, John D Hainsworth, Mathew J Joseph, Dianna L Shipley, M Kelly Hagan, Dana S Thompson, Howard A Burris, F Anthony Greco
BACKGROUND: The best treatment for patients with advanced non-small cell lung cancer (NSCLC) and a poor performance status is not well defined. In this phase 2 trial, patients were randomized to receive treatment with either single-agent pemetrexed or 1 of 2 combination regimens. METHODS: Patients with newly diagnosed, histologically confirmed nonsquamous NSCLC and an Eastern Cooperative Oncology Group (ECOG) performance status of 2 were stratified by age and serum albumin level and were randomized (1:1:1) to 1 of 3 regimens: pemetrexed (arm 1), pemetrexed and bevacizumab (arm 2), or pemetrexed, carboplatin, and bevacizumab (arm 3)...
February 16, 2018: Cancer
https://www.readbyqxmd.com/read/29449955/prospects-for-precision-medicine-in-glomerulonephritis-treatment
#12
REVIEW
Yulu Cherry Liu, Justin Chun
Background: Glomerulonephritis (GN) consists of a group of kidney diseases that are categorized based on shared histopathological features. The current classifications for GN make it difficult to distinguish the individual variability in presentation, disease progression, and response to treatment. GN is a significant cause of end-stage renal disease (ESRD), and improved therapies are desperately needed because current immunosuppressive therapies sometimes lack efficacy and can lead to significant toxicities...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29449201/peer-coaching-through-mhealth-targeting-physical-activity-in-people-with-parkinson-disease-feasibility-study
#13
Cristina Colón-Semenza, Nancy K Latham, Lisa M Quintiliani, Terry D Ellis
BACKGROUND: Long-term engagement in exercise and physical activity mitigates the progression of disability and increases quality of life in people with Parkinson disease (PD). Despite this, the vast majority of individuals with PD are sedentary. There is a critical need for a feasible, safe, acceptable, and effective method to assist those with PD to engage in active lifestyles. Peer coaching through mobile health (mHealth) may be a viable approach. OBJECTIVE: The purpose of this study was to develop a PD-specific peer coach training program and a remote peer-mentored walking program using mHealth technology with the goal of increasing physical activity in persons with PD...
February 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29448285/-risk-factors-and-therapeutic-goals-for-primary-and-secondary-cardiovascular-prevention-significance-for-the-glaucoma-patient
#14
Claudia Hacke, Carl Erb, Burkhard Weisser
Hypertension, diabetes mellitus and dyslipidaemia are among the most important cardiovascular risk factors. In addition, there is an association with the development and progression of glaucoma. During the last years, there has been an intense discussion concerning optimal treatment goals for these risk factors. Recently, the American Heart Association has defined a blood pressure greater than 130/80 mmHg as hypertension and the European guidelines will follow this definition. These lower blood pressure limits increase the risk for a too strict blood pressure treatment with night values, which might be too low for glaucoma patients...
February 2018: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29447142/prevalence-of-obesity-among-youths-by-household-income-and-education-level-of-head-of-household-united-states-2011-2014
#15
Cynthia L Ogden, Margaret D Carroll, Tala H Fakhouri, Craig M Hales, Cheryl D Fryar, Xianfen Li, David S Freedman
Obesity prevalence varies by income and education level, although patterns might differ among adults and youths (1-3). Previous analyses of national data showed that the prevalence of childhood obesity by income and education of household head varied across race/Hispanic origin groups (4). CDC analyzed 2011-2014 data from the National Health and Nutrition Examination Survey (NHANES) to obtain estimates of childhood obesity prevalence by household income (≤130%, >130% to ≤350%, and >350% of the federal poverty level [FPL]) and head of household education level (high school graduate or less, some college, and college graduate)...
February 16, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29446881/-zweckoptimismus-and-the-paris-process-will-not-save-the-world-from-climate-catastrophe
#16
Raymond Clémençon
Politicians, government officials, business representatives, and nongovernmental climate activists all in various ways emphasize what they see as progress being made in the aftermath of the Paris Agreement, even if they continue to warn of the dire consequences of business as usual. Indeed, there is no lack of encouraging private and public sector initiatives on climate change. Some macro trends seem to be moving in the right direction, as well. But, closer scrutiny shows that these positive trends are still far from adding up to the necessary fundamental shift in the global energy economy...
March 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29441673/plasma-assisted-synthesis-and-surface-modification-of-electrode-materials-for-renewable-energy
#17
REVIEW
Shuo Dou, Li Tao, Ruilun Wang, Samir El Hankari, Ru Chen, Shuangyin Wang
Renewable energy technology has been considered as a "MUST" option to lower the use of fossil fuels for industry and daily life. Designing critical and sophisticated materials is of great importance in order to realize high-performance energy technology. Typically, efficient synthesis and soft surface modification of nanomaterials are important for energy technology. Therefore, there are increasing demands on the rational design of efficient electrocatalysts or electrode materials, which are the key for scalable and practical electrochemical energy devices...
February 14, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29439661/genome-wide-scan-for-commons-snps-affecting-bovine-leukemia-virus-infection-level-in-dairy-cattle
#18
Hugo A Carignano, Dana L Roldan, María J Beribe, María A Raschia, Ariel Amadio, Juan P Nani, Gerónimo Gutierrez, Irene Alvarez, Karina Trono, Mario A Poli, Marcos M Miretti
BACKGROUND: Bovine leukemia virus (BLV) infection is omnipresent in dairy herds causing direct economic losses due to trade restrictions and lymphosarcoma-related deaths. Milk production drops and increase in the culling rate are also relevant and usually neglected. The BLV provirus persists throughout a lifetime and an inter-individual variation is observed in the level of infection (LI) in vivo. High LI is strongly correlated with disease progression and BLV transmission among herd mates...
February 13, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29439347/quantifying-the-diagnostic-pathway-for-patients-with-cognitive-impairment-real-world-data-from-seven-european-and-north-american-countries
#19
Craig W Ritchie, Christopher M Black, Rezaul K Khandker, Robert Wood, Eddie Jones, Xiaohan Hu, Baishali M Ambegaonkar
To ensure that patients with dementia and their caregivers receive appropriate treatment and support, early diagnosis is essential but remains challenging. Real-world data from a multi-national, cross-sectional survey of physicians and their patients were analyzed to quantify the diagnostic pathway for dementia, including a focus on severity of patients' cognitive impairment (CI) at the time of symptom onset, referral and subsequent diagnosis. Data were collected for 7,620 patients with CI. Most patients saw a healthcare professional within 1 year of first symptoms and received a diagnosis within 3-7 months of initial consultation...
2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29439005/randomised-controlled-trial-using-a-theory-based-m-health-intervention-to-improve-physical-activity-and-sleep-health-in-adults-the-synergy-study-protocol
#20
Beatrice Murawski, Ronald C Plotnikoff, Anna T Rayward, Corneel Vandelanotte, Wendy J Brown, Mitch J Duncan
INTRODUCTION: There is a need to reduce physical inactivity and poor sleep health in the adult population to decrease chronic disease rates and the associated burden. Given the high prevalence of these risk behaviours, effective interventions with potential for wide reach are warranted. METHODS AND ANALYSIS: The aim of this two-arm RCT will be to test the effect of a three month personalised mobile app intervention on two main outcomes: minutes of moderate-to-vigorous-intensity physical activity and overall sleep quality...
February 8, 2018: BMJ Open
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