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https://www.readbyqxmd.com/read/29058287/aberrant-activation-of-cdc2-cyclin-b1-is-involved-in-initiation-of-cytoskeletal-pathology-in-murine-niemann-pick-disease-type-c
#1
Li Ba, Zhi-Jun Li, Bi-Tao Bu, Wei Wang, Min Zhang
Niemann-Pick disease type C (NPC) is a fatal, neurovisceral lipid storage disease, neuropathologically characterized by cytoplasmic sequestration of glycolipids in neurons, progressive neuronal loss, neurofibrillary tangles (NFTs) formation, and axonal spheroids (AS). Cytoskeletal pathology including accumulation of hyperphosphorylated cytoskeletal proteins is a neuropathological hallmark of the mouse model of NPC (npc mice). With a goal of elucidating the mechanisms underlying the lesion formation, we investigated the temporal and spatial characteristics of cytoskeletal lesions and the roles of cdc2, cdk4, and cdk5 in lesion formation in young npc mice...
October 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/29058166/association-between-uremic-toxin-anthranilic-acid-and-fibrinolytic-system-activity-in-predialysis-patients-at-different-stages-of-chronic-kidney-disease
#2
Tomasz W Kaminski, Krystyna Pawlak, Malgorzata Karbowska, Michal Mysliwiec, Waldemar Grzegorzewski, Jakub Kuna, Dariusz Pawlak
PURPOSE: Chronic kidney disease (CKD) is an estimated risk factor for increased mortality and morbidity due to fibrinolytic system disturbances. Progressive loss of renal function leads to retention of uremic toxins. Anthranilic acid (AA) is a tryptophan-derived uremic toxin with multidirectional properties that can affect the hemostatic system. The goal of this study was to examine the association between AA and the parameters of fibrinolysis at different stages of CKD. METHODS: Patients with CKD were divided into two groups: mild-to-moderate (n = 20) and severe-to-end-stage CKD (n = 28)...
October 22, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/29057029/transthyretin-cardiac-amyloidosis-in-older-adults-optimizing-cardiac-imaging-to-the-corresponding-diagnostic-and-management-goal
#3
Adam Castaño, Daniel K Manson, Mathew S Maurer, Sabahat Bokhari
PURPOSE OF REVIEW: Transthyretin cardiac amyloidosis is increasingly recognized as an important cause of heart failure in older adults. Many cardiac imaging modalities have evolved to evaluate transthyretin cardiac amyloidosis and include 2D echocardiography with tissue Doppler and speckle-strain imaging, nuclear scintigraphy, cardiac magnetic resonance imaging, and positron emission tomography. The purpose of this review is to highlight the optimal selection of advanced cardiac imaging techniques with corresponding diagnostic goals including raising suspicion, making an early diagnosis, and subtyping transthyretin cardiac amyloid, as well as management goals including assessment of ventricular impairment, prognosticating, and monitoring disease progression...
June 2017: Current Cardiovascular Risk Reports
https://www.readbyqxmd.com/read/29056919/analysis-of-relations-between-spatiotemporal-movement-regulation-and-performance-of-discrete-actions-reveals-functionality-in-skilled-climbing
#4
REVIEW
Dominic Orth, Graham Kerr, Keith Davids, Ludovic Seifert
In this review of research on climbing expertise, we focus on different measures of climbing performance, including spatiotemporal measures related to fluency and activity states (i.e., discrete actions), adopted by climbers for achieving overall performance goals of getting to the end of a route efficiently and safely. Currently, a broad range of variables have been reported, however, many of these fail to capture how climbers adapt to a route whilst climbing. We argue that spatiotemporal measures should be considered concurrently with evaluation of activity states (such as reaching or exploring) in order gain a more comprehensive picture of how climbers successfully adapt to a route...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29055901/balancing-measures-or-a-balanced-accounting-of-improvement-impact-a-qualitative-analysis-of-individual-and-focus-group-interviews-with-improvement-experts-in-scotland
#5
Madalina Toma, Tobias Dreischulte, Nicola M Gray, Diane Campbell, Bruce Guthrie
BACKGROUND: As quality improvement (QI) programmes have become progressively larger scale, the risks of implementation having unintended consequences are increasingly recognised. More routine use of balancing measures to monitor unintended consequences has been proposed to evaluate overall effectiveness, but in practice published improvement interventions hardly ever report identification or measurement of consequences other than intended goals of improvement. METHODS: We conducted 15 semistructured interviews and two focus groups with 24 improvement experts to explore the current understanding of balancing measures in QI and inform a more balanced accounting of the overall impact of improvement interventions...
October 21, 2017: BMJ Quality & Safety
https://www.readbyqxmd.com/read/29055682/grade-ii-acute-gvhd-and-higher-nucleated-cell-graft-dose-improve-progression-free-survival-after-hla-haploidentical-transplant-with-posttransplant-cyclophosphamide
#6
Shannon R McCurdy, Christopher G Kanakry, Hua-Ling Tsai, Yvette L Kasamon, Margaret M Showel, Javier Bolaños-Meade, Carol Ann Huff, Ivan Borrello, William H Matsui, Robert A Brodsky, Richard F Ambinder, Maria P Bettinotti, Ephraim J Fuchs, Gary L Rosner, Richard J Jones, Leo Luznik
Compared with standard graft-versus-host disease (GVHD) prophylaxis platforms, posttransplantation cyclophosphamide (PTCy) after T-cell replete HLA-haploidentical (haplo) bone marrow transplantation (BMT) reduces the risk of grade III-IV acute (a) and chronic (c) GVHD, maintaining similar rates of grade II aGVHD. Given that mild GVHD has been associated with reduced treatment failure in HLA-matched BMT, we evaluated the risk factors for and effects of GVHD on survival in 340 adults with hematologic malignancies who engrafted after nonmyeloablative haplo BMT with PTCy, mycophenolate mofetil, and tacrolimus...
October 18, 2017: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29054268/saliva-exosomics-in-cancer-molecular-characterization-of-cancer-derived-exosomes-in-saliva
#7
Taichiro Nonaka, David T W Wong
Exosomes are small membrane vesicles of endocytic origin that are secreted by most cells and detected in saliva. Pathophysiological roles for salivary exosomes are beginning to be recognized in diseases including cancer, highlighting potential biomarkers and biological functions. Since early detection of cancer is vital for successful treatment, salivary exosomes would be advantageous in achieving a better survival rate due to their ready availability and noninvasiveness. The use of salivary exosomes may therefore be promising in the accurate detection of premalignant lesions and early-stage cancers, also for better our understanding of the molecular basis of tumorigenesis...
2017: Enzymes
https://www.readbyqxmd.com/read/29050926/-role-of-laser-peripheral-iridotomy-in-pigmentary-glaucoma-and-pigment-dispersion-syndrome-a-review-of-the-literature-french-version
#8
REVIEW
J Buffault, B Leray, A Bouillot, C Baudouin, A Labbé
PURPOSE: Pigment dispersion syndrome (PSD) is characterized by a structural abnormality of the posterior surface of the iris causing contact with the zonular fibers. It can lead to an open-angle glaucoma secondary to pigment dispersion into the trabecular meshwork. Laser peripheral iridotomy (PI) has been proposed as a treatment for pigmentary glaucoma (PG) and pigment dispersion syndrome (PDS) by reducing the dispersion of pigment. The goal of this review was to assess the effects of PI for PSD and PG...
October 16, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29050924/-progression-of-nerve-fiber-layer-defects-in-retrobulbar-optic-neuritis-by-the-macular-ganglion-cell-complex
#9
D Hong, C Bosc, F Chiambaretta
INTRODUCTION: Recent studies with SD OCT had shown early axonal damage to the macular ganglion cell complex (which consists of the three innermost layers of the retina: Inner Plexiform Layer [IPL], Ganglion Cell Layer [GCL], Retinal Nerve Fibre layer [RNFL]) in optic nerve pathology. Retrobulbar optic neuritis (RBON), occurring frequently in demyelinating diseases, leads to atrophy of the optic nerve fibers at the level of the ganglion cell axons, previously described in the literature...
October 16, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29050566/how-low-to-go-with-glucose-cholesterol-%C3%A2-and-blood-pressure-in-primary%C3%A2-prevention-of-cvd
#10
REVIEW
Kimberly N Hong, Valentin Fuster, Robert S Rosenson, Clive Rosendorff, Deepak L Bhatt
Diabetes, hyperlipidemia, and hypertension are modifiable risk factors that predict cardiovascular disease events. The effect of these risk factors on incident cardiovascular disease increases with progressively higher levels of glucose, low-density lipoprotein cholesterol, and blood pressure. The thresholds for initiating treatment of these modifiable risk factors and the optimal goals of risk factor modification are a focus of primary prevention research. Although an aggressive approach is appealing, adverse events may occur, and potential physiological barriers may exist...
October 24, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29049913/social-class-and-policy-preferences-implications-for-economic-inequality-and-interclass-relations
#11
REVIEW
Heather E Bullock
Record-setting levels of income and wealth inequality are deepening social class divisions. The adoption of strong progressive redistributive policies is crucial to reducing class inequities, yet many barriers to doing so exist. This review examines class-based policy preferences, focusing on the effects of economic self-interest, system justification, and classist, racist, and sexist stereotypes on policy support. The impact of broader economic conditions is also considered. Collectively, this body of research makes clear that building stronger cross-class support for redistributive policies and programs will prove difficult without addressing both class-based power differences and beliefs that justify inequality...
August 12, 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/29049344/exploring-the-link-between-innate-immune-activation-and-thymic-function-by-measuring-scd14-and-trecs-in-hiv-patients-living-in-belgium
#12
Adrien De Voeght, Henri Martens, Chantal Renard, Dolores Vaira, Mathieu Debruche, Julie Simonet, Vincent Geenen, Michel Moutschen, Gilles Darcis
Microbial translocation is now viewed as a central event in the pathogenesis of chronic inflammation during HIV infection. Thymic function failure is another crucial factor involved in HIV disease progression. The goal of this study was to explore the hypothesis of potential links between microbial translocation and thymic function in HIV-1 patients living in Belgium. The extent of microbial translocation was assessed through the measurement of soluble CD14 (sCD14). T-cell receptor excision circles (sjTRECs and dβTRECs) were used as a measure of thymic function...
2017: PloS One
https://www.readbyqxmd.com/read/29049269/long-term-surgical-outcomes-after-early-definitive-spinal-fusion-for-early-onset-scoliosis-with-neurofibromatosis-type-1-at-mean-follow-up-of-14-years
#13
Ryoji Tauchi, Noriaki Kawakami, Michael Anton Castro, Tetsuya Ohara, Toshiki Saito, Kazuaki Morishita, Ippei Yamauchi
BACKGROUND: Several authors mentioned surgical outcome for scoliosis associated with neurofibromatosis type 1 (NF-1). However, no studies have summarized long-term surgical outcomes after surgical treatment of early-onset scoliosis (EOS) with NF-1. The purpose of this study is to evaluate the long-term surgical outcome after early definitive spinal fusion for EOS in NF-1 patients. METHODS: We performed a retrospective review on a cohort of 11 patients diagnosed with EOS associated with NF-1 between 1990 and 2009 in our hospital...
October 18, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29048670/suppression-of-tumor-derived-semaphorin%C3%A2-7a-and-genetic-ablation-of-host-derived-semaphorin%C3%A2-7a-impairs-tumor-progression-in-a-murine-model-of-advanced-breast-carcinoma
#14
R Garcia-Areas, S Libreros, M Simoes, C Castro-Silva, N Gazaniga, S Amat, J Jaczewska, P Keating, K Schilling, M Brito, E P Wojcikiewicz, V Iragavarpu-Charyulu
Solid tumors can generate a plethora of neurogenesis-related molecules that enhance their growth and metastasis. Among them, we have identified axonal guidance molecule Semaphorin 7A (SEMA7A) in breast cancer. The goal of this study was to determine the therapeutic effect of suppressing SEMA7A levels in the 4T1 murine model of advanced breast carcinoma. We used anti-SEMA7A short hairpin RNA (shRNA) to gene silence SEMA7A in 4T1 mammary tumor cells. When implanted into the mammary fat pads of syngeneic mice, SEMA7A shRNA-expressing 4T1 tumors exhibited decreased growth rates, deferred metastasis and reduced mortality...
October 3, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29047450/quantum-modeling-of-ultrafast-photoinduced-charge-separation
#15
Carlo Andrea Rozzi, Filippo Troiani, Ivano Tavernelli
Phenomena involving electron transfer are ubiquitous in nature, photosynthesis and enzymes or protein activity being prominent examples. Their deep understanding thus represents a mandatory scientific goal. Moreover, controlling the separation of photogenerated charges is a crucial prerequisite in many applicative contexts, including quantum electronics, photo-electrochemical water splitting, photocatalytic dye degradation, and energy conversion. In particular, photoinduced charge separation is the pivotal step driving the storage of sun light into electrical or chemical energy...
October 19, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29047077/adventitial-fibroblast-nox4-expression-and-ros-signaling-in-pulmonary-arterial-hypertension
#16
Scott A Barman, David Fulton
Pulmonary arterial hypertension (PAH) is a progressive disease arising from remodeling and narrowing of pulmonary arteries (PA) resulting in high pulmonary arterial blood pressure and ultimately right ventricular failure. Elevated production of reactive oxygen species (ROS) by NADPH oxidase 4 (Nox4), a constitutively active enzyme, has been associated with oxygen sensing, vasomotor control, cellular proliferation, differentiation, migration, apoptosis, senescence, fibrosis, and angiogenesis. Further, elevated expression of Nox4 has been reported in a number of cardiovascular diseases, including atherosclerosis, hypertension, cardiac failure, ischemic stroke, and PAH...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29046222/a-social-network-analysis-of-the-goal-scoring-passing-networks-of-the-2016-european-football-championships
#17
Scott Mclean, Paul M Salmon, Adam D Gorman, Nicholas J Stevens, Colin Solomon
In the current study, social network analysis (SNA) and notational analysis (NA) methods were applied to examine the goal scoring passing networks (GSPN) for all goals scored at the 2016 European Football Championships. The aim of the study was to determine the GSPN characteristics for the overall tournament, between the group and knock out stages, and for the successful and unsuccessful teams. The study also used degree centrality (DC) metrics as a novel method to determine the relative contributions of the pitch locations involved in the GSPN...
October 16, 2017: Human Movement Science
https://www.readbyqxmd.com/read/29046174/gravitational-and-somatosensory-influences-on-control-and-perception-of-roll-balance
#18
Alexander Sacha Panic, Heather Panic, Paul DiZio, James R Lackner
INTRODUCTION: Blindfolded subjects used a joystick to orient themselves to the direction of balance in a device programmed to exhibit inverted pendulum behavior in the roll plane; they indicated with a trigger press when they were at that location. Our goal was to determine how otolith and somatosensory information about the gravitational vertical influenced the ability to locate the direction of balance. METHODS: The subjects (N = 12) were tested in each of three orientations of the body roll plane: vertical (Upright), 45° back (45_Degree), and 90° back (Supine), which provided progressively less salient otolith and somatosensory information about roll orientation with regard to the direction of gravity...
November 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29046054/porphyromonas-gingivalis-lipopolysaccharide-stimulation-in-human-periodontal-ligament-stem-cells-role-of-epigenetic-modifications-to-the-inflammation
#19
Francesca Diomede, Soundara Rajan Thangavelu, Ilaria Merciaro, Monica D'Orazio, Placido Bramanti, Emanuela Mazzon, Oriana Trubiani
Periodontitis is a chronic oral inflammatory disease produced by bacteria. Gingival retraction and bone and connective tissues resorption are the hallmarks of this disease. Chronic periodontitis may contribute to the risk of onset or progression of neuroinflammatory pathological conditions, such as Alzheimer's disease. The main goal of the present study was to investigate if the role of epigenetic modulations is involved in periodontitis using human periodontal ligament stem cells (hPDLSCs) as an in vitro model system...
August 25, 2017: European Journal of Histochemistry: EJH
https://www.readbyqxmd.com/read/29045698/remission-in-psoriatic-arthritis-where-are-we-now
#20
Laura C Coates, Philip G Conaghan, Maria Antonietta D'Agostino, Maarten De Wit, Oliver FitzGerald, Tore K Kvien, Rik Lories, Philip Mease, Peter Nash, Georg Schett, Enrique R Soriano, Paul Emery
Advances in treatments and treatment strategies for PsA have led to many patients responding well to management of their disease, and targeting remission as a treatment goal is now a possibility. Treat to target is a strategy aimed at maximizing benefit, irrespective of the type of medication used, by monitoring disease activity and using it to guide therapy. The measurement of response to treatment has been the subject of wide discussions among experts for some time, and many instruments exist. Comparisons of the different measures and their different strengths and weaknesses is ongoing...
October 16, 2017: Rheumatology
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