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https://www.readbyqxmd.com/read/29663100/quinazoline-clubbed-1-3-5-triazine-derivatives-as-vegfr2-kinase-inhibitors-design-synthesis-docking-in-vitro-cytotoxicity-and-in-ovo-antiangiogenic-activity
#1
Prateek Pathak, Parjanya Kumar Shukla, Vikas Kumar, Ankit Kumar, Amita Verma
A series of quinazoline clubbed 1,3,5-triazine derivatives (QCT) were synthesized and evaluated for their in vitro anticancer activity against HeLa (human cervical cancer), MCF-7 (human breast cancer cell), HL-60 (human promyelocytic leukemia cell), HepG2 (human Hepatocellular carcinoma cell), and one normal cell line HFF (human foreskin fibroblasts). In vitro assay result encouraged to further move towards in ovo anticancer evaluation using chick embryo. The series of QCT derivatives showed higher anticancer and antiangiogenic activity against HeLa and MCF-7 cell lines...
April 16, 2018: Inflammopharmacology
https://www.readbyqxmd.com/read/29660406/is-antimicrobial-administration-to-food-animals-a-direct-threat-to-human-health-a-rapid-systematic-review
#2
REVIEW
Anna Mae Scott, Elaine Beller, Paul Glasziou, Justin Clark, Respati W Ranakusuma, Oyungerel Byambasuren, Mina Bakhit, Stephen W Page, Darren Trott, Chris Del Mar
BACKGROUND: Large quantities of antimicrobials are given to food animals, especially in feed, potentially risking increased antimicrobial resistance in humans. However, the magnitude of this effect is unclear. METHODS: We searched PubMed, Embase and Web of Science, for studies on interventions which limited antimicrobial use in food animals, in any setting and context, to reduce antimicrobial resistance 1) in those food animals; and 2) in humans. We validated our strategy by testing whether it identifies known relevant studies...
April 13, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29649432/nitric-oxide-signaling-regulates-tumor-induced-intussusceptive-like-angiogenesis
#3
Selvaraj Vimalraj, Srinivasan Bhuvaneswari, Sundaresan Lakshmikirupa, Ganesh Jyothsna, Suvro Chatterjee
Existing animal models for screening tumor angiogenic process have various setbacks that necessitate further investigations. In this study, we developed an ex-ovo egg yolk angiogenesis model to screen the angiogenic potency of tumor cells (HeLa and SiHa cell lines). The egg yolk angiogenesis assay was applied to study the nitric oxide (NO) influence on switching from sprouting angiogenesis (SA) to intussusceptive angiogenesis (IA) under tumor microenvironment. Morphological analysis and SA-like or IA-like markers expression were determined during the development of chicken chorioallantoic membrane (CAM) from day 5 to 13...
April 9, 2018: Microvascular Research
https://www.readbyqxmd.com/read/29617899/in-ovo-applications-in-poultry-a-review
#4
E D Peebles
The various methods employed for the in ovo administration of different materials for promoting the health and productivity of poultry are discussed in this review article. The amnion has proven to be an effective site for injection and the timing of in ovo injection has commonly occurred at transfer. However, the volumes and dosages or concentrations of the materials administered vary depending on bird type, egg size, timing and site of injection, incubation system and regimen, and the type of material. Both manual and automated injections have been shown to be effective...
March 28, 2018: Poultry Science
https://www.readbyqxmd.com/read/29616069/association-study-reveals-novel-genes-related-to-yield-and-quality-of-fruit-in-cape-gooseberry-physalis-peruviana-l
#5
Francy L García-Arias, Jaime A Osorio-Guarín, Victor M Núñez Zarantes
Association mapping has been proposed as an efficient approach to assist plant breeding programs to investigate the genetic basis of agronomic traits. In this study, we evaluated 18 traits related to yield, (FWP, NF, FWI, and FWII), fruit size-shape (FP, FA, MW, WMH, MH, HMW, DI, FSI, FSII, OVO, OBO), and fruit quality (FIR, CF, and SST), in a diverse collection of 100 accessions of Physalis peruviana including wild, landraces, and anther culture derived lines. We identified seven accessions with suitable traits: fruit weight per plant (FWP) > 7,000 g/plant and cracked fruits (CF) < 4%, to be used as parents in cape gooseberry breeding program...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29608115/improving-colloidal-stability-of-silica-nanoparticles-when-stored-in-responsive-gel-application-and-toxicity-study
#6
Giorgia Giovannini, Paul Warncke, Dagmar Fischer, Ondrej Stranik, Andrew J Hall, Vladimir Gubala
When silica nanoparticles (SiNP) are stored in aqueous solution, even for few hours, they have a tendency to form agglomerates and therefore adapt inhomogeneous structures. Here we present a very practical method to store SiNP in responsive hydrogel. We have confirmed that SiNP kept in the responsive hydrogel do not undergo through undesirable morphological changes and while in storage they maintain their excellent colloidal stability. The effect of SiNP hollowing (i.e. dissolution of the core of the particles that leaves empty cavity inside) was significantly inhibited in the hydrogel, which is a critical feature for any nano-medical applications (e...
April 2, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29607880/a-novel-nuclear-localization-signal-spans-the-linker-of-the-two-dna-binding-subdomains-in-the-conserved-paired-domain-of-pax6
#7
Hiromasa Tabata, Akihiro Koinui, Atsushi Ogura, Daisuke Nishihara, Hiroaki Yamamoto
Paired box (Pax) 6, a member of the Pax family of transcription factors, contains two DNA-binding domains, called the paired domain (PD) and the homeodomain (HD), and plays pivotal roles in development of structures such as the eye, central nervous system and pancreas. Pax6 is a major developmental switching molecule because, for example, ectopic expression of the Pax6 gene can induce ectopic whole eye development. Intensive research has been devoted to elucidating the molecular mechanism(s) involved in the function(s) of Pax6, but many issues remain unexplained...
April 2, 2018: Genes & Genetic Systems
https://www.readbyqxmd.com/read/29597266/the-in-ovo-feeding-administration-gallus-gallus-an-emerging-in-vivo-approach-to-assess-bioactive-compounds-with-potential-nutritional-benefits
#8
REVIEW
Tao Hou, Elad Tako
In recent years, the in ovo feeding in fertilized broiler ( Gallus gallus ) eggs approach was further developed and currently is widely applied in the evaluation process of the effects of functional foods (primarily plant origin compounds) on the functionality of the intestinal brush border membrane, as well as potential prebiotic properties and interactions with the intestinal microbial populations. This review collates the information of potential nutrients and their effects on the mineral absorption, gut development, brush border membrane functionality, and immune system...
March 28, 2018: Nutrients
https://www.readbyqxmd.com/read/29596926/effects-of-prenatal-exposure-to-triclosan-on-the-liver-transcriptome-in-chicken-embryos
#9
Jiahua Guo, Shohei Ito, Hoa Thanh Nguyen, Kimika Yamamoto, Rumi Tanoue, Tatsuya Kunisue, Hisato Iwata
Triclosan (TCS), a commonly used antimicrobial compound, has recently been detected in the eggs of wild avian species. Exposure to TCS in rodents is known to interfere with thyroid hormone (TH), disrupt immune responses and cause liver disease. However, no attempt has made to clarify the effects of TCS in avian species. The aim of this study is therefore to evaluate the toxic effects of in ovo exposure to TCS and explore the molecular mechanism by transcriptome analysis in the embryonic liver of a model avian species, chicken (Gallus gallus)...
March 26, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29587743/proteomic-analysis-of-antimicrobial-effects-of-pegylated-silver-coated-carbon-nanotubes-in-salmonella-enterica-serovar-typhimurium
#10
Seong B Park, Christy S Steadman, Atul A Chaudhari, Shreekumar R Pillai, Shree R Singh, Peter L Ryan, Scott T Willard, Jean M Feugang
BACKGROUND: Synthesis of silver nano-compounds with enhanced antimicrobial effects is of great interest for the development of new antibacterial agents. Previous studies have reported the antibacterial properties of pegylated silver-coated carbon nanotubes (pSWCNT-Ag) showing less toxicity in human cell lines. However, the mechanism underlining the pSWCNT-Ag as a bactericidal agent remained unfolded. Here we assessed the pSWCNT-Ag effects against foodborne pathogenic bacteria growth and proteome profile changes...
March 27, 2018: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/29575743/potential-of-lactobacillus-plantarum-ibb3036-and-lactobacillus-salivarius-ibb3154-to-persistence-in-chicken-after-in-ovo-delivery
#11
Tamara Aleksandrzak-Piekarczyk, Weronika Puzia, Joanna Żylińska, Jarosław Cieśla, Krzysztof A Gulewicz, Jacek K Bardowski, Roman K Górecki
The aim of this study was to characterize and compare selected Lactobacillus strains originating from different environments (cow milk and hen feces) with respect to their applicative potential to colonize gastrointestinal track of chickens before hatching from an egg. In vitro phenotypic characterization of lactobacilli strains included the investigation of the important prerequisites for persistence in gastrointestinal tract, such as a capability to survive in the presence of bile salts and at low pH, enzymatic and sugar metabolic profiles, adhesion abilities, and resistance to osmolytes, temperature, and antibiotics...
March 25, 2018: MicrobiologyOpen
https://www.readbyqxmd.com/read/29574664/wnt3a-ectopic-expression-interferes-axonal-projection-and-motor-neuron-positioning-during-the-chicken-spinal-cord-development
#12
Qiuling Li, Ciqing Yang, Bichao Zhang, Zhikun Guo, Juntang Lin
The formation of dorsal-ventral axis of the spinal cord is controlled largely by dorsal signals such as Wnts (which are members of the wingless + MMTV integrants, Int family), besides ventral signals such as sonic hedgehog (Shh). Wnt3a, one of the Wnt family members, is involved in multiple cellular functions, including self-renewal, proliferation, differentiation, and motility. Here, we aim to study the mechanism of the regulation of chicken spinal cord patterning by Wnt3a. In this study, Wnt3a was ectopically expressed in the spinal cord of developing chicken embryos by in ovo electroporation...
March 25, 2018: Journal of Molecular Neuroscience: MN
https://www.readbyqxmd.com/read/29562345/in-ovo-green-light-photostimulation-during-different-embryonic-stages-affect-somatotropic-axis
#13
L Dishon, N Avital-Cohen, S Zaguri, J Bartman, R Heiblum, S Druyan, T E Porter, M Gumulka, I Rozenboim
Previous studies demonstrated that in-ovo photostimulation with monochromatic green light increased the somatotropic axis expression in broilers embryos. The objective of the current study was to detect the critical period for in-ovo GL photostimulation, in order to find the optimal targeted photostimulation period during the incubation process. Three hundred thirty-six fertile broiler eggs were divided into 4 groups. The first group was incubated under dark conditions as a negative control. The second incubated under intermittent monochromatic green light using light-emitting diode (LED) lamps with an intensity of 0...
March 16, 2018: Poultry Science
https://www.readbyqxmd.com/read/29548853/in-ovo-testing-of-flavor-and-fragrance-materials-in-turkey-egg-genotoxicity-assay-tega-comparison-of-results-to-in-vitro-and-in-vivo-data
#14
Tetyana Kobets, Jian-Dong Duan, Klaus D Brunnemann, Michael J Iatropoulos, Sylvain Etter, Christina Hickey, Benjamin Smith, Gary M Williams
Genotoxicity of flavor and fragrance materials was assessed in Turkey Egg Genotoxicity Assay (TEGA) using32 P-nucleotide postlabeling (NPL) and comet assays to detect hepatic DNA adducts and strand breaks. Twenty materials having results in GADD45a-Gluc 'BlueScreen HC' genotoxicity assay, and standard in vitro and in vivo tests, were selected to evaluate the accuracy of TEGA. Quinoline (QUI) and 2-acetylaminofluorene (AAF) served as positive comparators. Two materials, p-tert-butyldihydrocinnamaldehyde (BDHCA) and methyl eugenol (MEU) produced DNA adducts...
March 13, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29546310/corticosterone-induced-lipogenesis-activation-and-lipophagy-inhibition-in-chicken-liver-are-alleviated-by-maternal-betaine-supplementation
#15
Yun Hu, Qinwei Sun, Yan Hu, Zhen Hou, Yibo Zong, Nagmeldin A Omer, Halima Abobaker, Ruqian Zhao
Background: We have shown previously that in ovo betaine injection can prevent nonalcoholic fatty liver induced by glucocorticoid exposure in chickens; yet it remains unknown whether feeding betaine to laying hens may exert similar effects in their progeny. Objective: In this study, we fed laying hens a betaine-supplemented diet, and the progeny were later exposed chronically to corticosterone (CORT) to test hepatoprotective effects and further elucidate underlying mechanisms...
March 1, 2018: Journal of Nutrition
https://www.readbyqxmd.com/read/29533151/comparison-of-renal-function-and-other-predictors-in-lacto-ovo-vegetarians-and-omnivores-with-chronic-kidney-disease
#16
Chou-Yueh Chang, Horng-Rong Chang, Hsing-Chun Lin, Han-Hsin Chang
Objective Vegetarian diets have been shown to increase the risk of certain nutritional deficiencies, such as iron. As a number of patients with chronic kidney disease (CKD) in Taiwan are lacto-ovo vegetarians, the aim of this study was to investigate the effects of different proportions and sources of protein in lacto-ovo vegetarian and omnivorous diets, as well as the influence of adequate dietary protein intake, on renal function and nutritional status of Taiwanese patients with stage 3 to stage 5 CKD. Methods This is a cross-sectional study...
March 13, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29531252/nutritionally-recommended-food-for-semi-to-strict-vegetarian-diets-based-on-large-scale-nutrient-composition-data
#17
Seunghyeon Kim, Michael F Fenech, Pan-Jun Kim
Diet design for vegetarian health is challenging due to the limited food repertoire of vegetarians. This challenge can be partially overcome by quantitative, data-driven approaches that utilise massive nutritional information collected for many different foods. Based on large-scale data of foods' nutrient compositions, the recent concept of nutritional fitness helps quantify a nutrient balance within each food with regard to satisfying daily nutritional requirements. Nutritional fitness offers prioritisation of recommended foods using the foods' occurrence in nutritionally adequate food combinations...
March 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29530633/chicken-immune-response-following-in-ovo-delivery-of-bacterial-flagellin
#18
M M Vaezirad, M G Koene, J A Wagenaar, J P M van Putten
In ovo immunization of chicken embryos with live vaccines is an effective strategy to protect chickens against several viral pathogens. We investigated the immune response of chicken embryos to purified recombinant protein. In ovo delivery of Salmonella flagellin to 18-day old embryonated eggs resulted in elevated pro-inflammatory chIL-6 and chIL-8 (CXCL8-CXCLi2) cytokine transcript levels in the intestine but not in the spleen at 24 h post-injection. Analysis of the chicken Toll-like receptor (TLR) repertoire in 19-day old embryos revealed gene transcripts in intestinal and spleen tissue for most chicken TLRs, including TLR5 which recognizes Salmonella flagellin (FliC)...
March 9, 2018: Vaccine
https://www.readbyqxmd.com/read/29530062/potential-mediators-of-in-ovo-delivered-double-stranded-ds-rna-induced-innate-response-against-low-pathogenic-avian-influenza-virus-infection
#19
Hanaa Ahmed-Hassan, Mohamed Sarjoon Abdul-Cader, Upasama De Silva Senapathi, Maha Ahmed Sabry, Eman Hamza, Eva Nagy, Shayan Sharif, Mohamed Faizal Abdul-Careem
BACKGROUND: Toll like receptor (TLR) 3 is a critically important innate pattern recognizing receptor that senses many viral infections. Although, it has been shown that double stranded (ds) RNA can be used for the stimulation of TLR3 signaling pathway in a number of host-viral infection models, it's effectiveness as an antiviral agent against low pathogenic avian influenza virus (LPAIV) needs further investigation. METHODS: In this study, first, we delivered TLR3 ligand, dsRNA, in ovo at embryo day (ED)18 since in ovo route is routinely used for vaccination against poultry viral and parasitic infections and infected with H4N6 LPAIV 24-h post-treatment...
March 12, 2018: Virology Journal
https://www.readbyqxmd.com/read/29527160/a-ternary-hybrid-eeg-nirs-brain-computer-interface-for-the-classification-of-brain-activation-patterns-during-mental-arithmetic-motor-imagery-and-idle-state
#20
Jaeyoung Shin, Jinuk Kwon, Chang-Hwan Im
The performance of a brain-computer interface (BCI) can be enhanced by simultaneously using two or more modalities to record brain activity, which is generally referred to as a hybrid BCI. To date, many BCI researchers have tried to implement a hybrid BCI system by combining electroencephalography (EEG) and functional near-infrared spectroscopy (NIRS) to improve the overall accuracy of binary classification. However, since hybrid EEG-NIRS BCI, which will be denoted by hBCI in this paper, has not been applied to ternary classification problems, paradigms and classification strategies appropriate for ternary classification using hBCI are not well investigated...
2018: Frontiers in Neuroinformatics
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