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https://www.readbyqxmd.com/read/29242123/ensemble-of-random-forests-one-vs-rest-classifiers-for-mci-and-ad-prediction-using-anova-cortical-and-subcortical-feature-selection-and-partial-least-squares
#1
J Ramírez, J M Górriz, A Ortiz, F J Martínez-Murcia, F Segovia, D Salas-Gonzalez, D Castillo-Barnes, I A Illán, C G Puntonet
BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia in the elderly and affects approximately 30 million individuals worldwide. Mild cognitive impairment (MCI) is very frequently a prodromal phase of AD, and existing studies have suggested that people with MCI tend to progress to AD at a rate of about 10% to 15% per year. However, the ability of clinicians and machine learning systems to predict AD based on MRI biomarkers at an early stage is still a challenging problem that can have a great impact in improving treatments...
December 11, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29239804/sex-determination-and-differentiation-genes-in-a-functional-hermaphrodite-scallop-nodipecten-subnodosus
#2
Pavel Galindo-Torres, Alejandra García-Gasca, Raúl Llera-Herrera, Cristina Escobedo-Fregoso, Cei Abreu-Goodger, Ana M Ibarra
The lion-paw, Nodipecten subnodosus is one of three scallop species commercially exploited on the west coast of the Peninsula of Baja California. Because nothing is known about sex determination and sexual differentiation in hermaphrodite scallops, in the present work, a global transcriptomic analysis was performed in two early developmental stages, settling eyed-larvae and spat, as well as in three tissues (undifferentiated gonad, digestive gland, and adductor muscle). Over 27 million Illumina paired-end reads were obtained through the MiSeq platform...
November 24, 2017: Marine Genomics
https://www.readbyqxmd.com/read/29233192/methanolic-extract-of-euchelus-asper-exhibits-in-ovo-anti-angiogenic-and-in-vitro-anti-proliferative-activities
#3
Sweta Agrawal, Sachin Chaugule, Shashank More, Gargi Rane, Madhavi Indap
BACKGROUND: The marine environment is a rich source of bioactive natural products. Many of the marine bioactive compounds have been derived successfully from molluscs. Euchelus asper is a marine mollusc which is commonly found in the intertidal rocky regions of the Mumbai coast. The present study was focused on evaluating the anti-angiogenic and anti- proliferative activities of methanolic extract of Euchelus asper (EAME). METHODS: The anti-angiogenic activity of EAME (50-800 μg/mL) was assessed by chick chorio-allantoic membrane (CAM) model wherein multiple parameters in the CAM blood vessels were analysed through morphometric and histological investigations...
December 12, 2017: Biological Research
https://www.readbyqxmd.com/read/29228782/antioxidant-defence-in-the-brain-of-one-day-old-chickens-exposed-in-ovo-to-acrylamide
#4
M Batoryna, M W Lis, G Formicki
1. Acrylamide (ACR) is a potent neurotoxicant, although information on its toxic influence on the developing neural system is still limited. We examined the effect of in-ovo-injected ACR on the antioxidant system activity in the brain of new hatched chickens. This model eliminated the mother's contribution to embryonic development. It was also recognised as an adequate model for animal embryonic development. 2. ACR was injected on day 4 of embryogenesis- in doses of 1.25 and 2.50 mg per egg (n=40 eggs per group/120 eggs)...
December 12, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29208362/feminizing-effects-of-exposure-to-corexit-enhanced-water-accommodated-fraction-of-crude-oil-in-vitro-on-sex-determination-in-alligator-mississippiensis
#5
Cameron E Williams, Nicole A McNabb, Arnold Brunell, Russell H Lowers, Yoshinao Katsu, Demetri D Spyropoulos, Satomi Kohno
Deepwater Horizon spilled over 200 million gallons of oil into the waters of the Gulf of Mexico in 2010. In an effort to contain the spill, chemical dispersants were applied to minimize the amount of oil reaching coastal shorelines. However, the biological impacts of chemically-dispersed oil are not well characterized, and there is a particular lack of knowledge concerning sublethal long-term effects of exposure. This study examined potential estrogenic effects of CWAF, Corexit 9500-enhanced water-accommodated fraction of oil, by examining its effect on estrogen receptors and sex determination in the American alligator, Alligator mississippiensis...
December 2, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29206486/the-method-of-chicken-whole-embryo-culture-using-the-eggshell-windowing-surrogate-eggshell-and-ex-ovo-culture-system
#6
M Farzaneh, F Attari, S E Khoshnam, P E Mozdziak
1. The unique accessibility of the avian embryo have made them an ideal model for the study of development and genome editing. Chicken whole embryo culture has provided important insights into toxicity tests, gene manipulation, clarifying gene functions, cell transplantation, and cell tracking. 2. A simple technique for chicken manipulation is eggshell windowing, without or with seal, the latter having demonstrated some improvement in hatching rates. 3. Likewise, a surrogate eggshell system provides an accessible model for manipulation during chicken and quail development, with a higher hatchability compared to the simple windowing method...
December 5, 2017: British Poultry Science
https://www.readbyqxmd.com/read/29203322/effects-of-in-ovo-exposure-to-benzo-k-fluoranthene-bkf-on-cyp1a-expression-and-promoter-methylation-in-developing-chicken-embryos
#7
Jonas Brandenburg, Jessica A Head
Polycyclic aromatic hydrocarbons (PAHs) are toxic environmental pollutants that are potent teratogens. Recent research suggests that early life exposure to PAHs can affect health outcomes later in life. Some of these latent responses may be mediated by epigenetic mechanisms such as DNA methylation. The role of DNA methylation in regulating responses to PAHs in birds is currently unknown. Here, we assess the effect of in ovo exposure to the model PAH, benzo[k]fluoranthene (BkF), on aryl hydrocarbon receptor (AHR) mediated cytochrome P4501A (CYP1A) gene expression and promoter methylation in chicken embryos...
December 1, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/29193030/ankle-muscle-tenotomy-does-not-alter-ankle-flexor-muscle-recruitment-bias-during-locomotor-related-repetitive-limb-movement-in-late-stage-chick-embryos
#8
Soo Yeon Sun, Lucinda L Baker, Nina S Bradley
In ovo, late-stage chick embryos repetitively step spontaneously, a locomotor-related behavior also identified as repetitive limb movement (RLM). During RLMs, there is a flexor bias in recruitment and drive of leg muscle activity. The flexor biased activity occurs as embryos assume an extremely flexed posture in a spatially restrictive environment 2-3 days before hatching. We hypothesized that muscle afferent feedback under normal mechanical constraint is a significant input to the flexor bias observed during RLMs on embryonic day (E) 20...
November 28, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/29179815/charge-syndrome-modeling-using-patient-ipscs-reveals-defective-migration-of-neural-crest-cells-harboring-chd7-mutations
#9
Hironobu Okuno, Francois Renault Mihara, Shigeki Ohta, Kimiko Fukuda, Kenji Kurosawa, Wado Akamatsu, Tsukasa Sanosaka, Jun Kohyama, Kanehiro Hayashi, Kazunori Nakajima, Takao Takahashi, Joanna Wysocka, Kenjiro Kosaki, Hideyuki Okano
CHARGE syndrome is caused by heterozygous mutations in the chromatin remodeler, CHD7, and is characterized by a set of malformations that, on clinical grounds, were historically postulated to arise from defects in neural crest formation during embryogenesis. To better delineate neural crest defects in CHARGE syndrome, we generated induced pluripotent stem cells (iPSCs) from two patients with typical syndrome manifestations, and characterized neural crest cells differentiated in vitro from these iPSCs (iPSC-NCCs)...
November 28, 2017: ELife
https://www.readbyqxmd.com/read/29177455/investigating-commercial-in-ovo-technology-as-a-strategy-for-introducing-probiotic-bacteria-to-broiler-embryos
#10
M D Triplett, W Zhai, E D Peebles, C D McDaniel, A S Kiess
Probiotics can improve broiler performance and reduce pathogens. Because the hatchery can be a source of contamination, delivering probiotics to the embryo before hatch is desirable. To date, probiotics have primarily been injected into eggs manually. Therefore, the objective of this study was to deliver various probiotic bacteria into broiler hatching eggs using an automated commercial in ovo injection system to evaluate hatchability of fertile eggs (HF). Three separate experiments were conducted using Lactobacillus acidophilus, Bacillus subtilis, or Bifidobacterium animalis...
November 21, 2017: Poultry Science
https://www.readbyqxmd.com/read/29173898/human-pluripotent-stem-cell-differentiation-into-functional-epicardial-progenitor-cells
#11
Juan Antonio Guadix, Valeria V Orlova, Elisa Giacomelli, Milena Bellin, Marcelo C Ribeiro, Christine L Mummery, José M Pérez-Pomares, Robert Passier
Human pluripotent stem cells (hPSCs) are widely used to study cardiovascular cell differentiation and function. Here, we induced differentiation of hPSCs (both embryonic and induced) to proepicardial/epicardial progenitor cells that cover the heart during development. Addition of retinoic acid (RA) and bone morphogenetic protein 4 (BMP4) promoted expression of the mesodermal marker PDGFRα, upregulated characteristic (pro)epicardial progenitor cell genes, and downregulated transcription of myocardial genes...
November 17, 2017: Stem Cell Reports
https://www.readbyqxmd.com/read/29160181/chick-embryo-model-homing-and-host-interactions-of-tissue-engineering-aimed-human-dental-stem-cells
#12
Jennifer Adriane Dos Santos, Monica Talarico Duailibi, Durvanei Augusto Maria, Sonia Elisabete Alves de Lima Will, Paulo Cesar Simoes Silva, Ligia Ferreira Gomes, Silvio Eduardo Duailibi
Human dental stem cells (hDSC) have a potential for regenerative therapies and could differentiate in vitro into many tissues such as dentin, nerve and vascular endothelium. Gallus gallus domesticus developing fertilized egg, or chick embryo is an experimental model absent of xenografts rejection, largely employed in replacement of mammal species in scientific research and pre-clinical studies to evaluate angiogenesis and vasculogenesis, tissue differentiation, and embryonic development. This multiscale research deals with the homing and cell signaling effects of a standardized hDSC towards the receptor tissues of Gallus gallus domesticus in ovo...
November 21, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29157369/risk-factors-associated-with-the-a2c-resistance-pattern-among-e-coli-isolates-from-broiler-flocks-in-canada
#13
Niamh Caffrey, Omid Nekouei, Sheryl Gow, Agnes Agunos, Sylvia Checkley
The extra-label use of ceftiofur in Canadian hatcheries was cause for concern due to an increased prevalence of ceftiofur resistant Salmonella Heidelberg in chickens and humans in Québec. Due to on-going concerns related to human health the use of ceftiofur was eventually phased out of the poultry production industry in 2014-2015. Simultaneous resistance to amoxicillin-clavulanic acid, ceftiofur and cefoxitin, a pattern known as A2C, caused by the presence of blaCMY-2 has become increasingly prevalent in broiler flocks worldwide...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29155971/in-ovo-injection-of-ascorbic-acid-modulates-antioxidant-defense-system-and-immune-gene-expression-in-newly-hatched-local-chinese-yellow-broiler-chicks
#14
H K El-Senousey, B Chen, J Y Wang, A M Atta, F R Mohamed, Q H Nie
The present study was conducted to investigate the effects of in ovo injection of ascorbic acid on antioxidant capacity and immune-related gene expression in the newly hatched local Chinese yellow broiler chicks. Fertile Chinese yellow broiler eggs (n = 90) were assigned to three equal groups. The first group was a non-injected control group. The second group was another control group where the eggs were injected with saline in the air sac after 18 days of incubation. The third group was injected with 3 mg/egg AA in the air sac after 18 days of incubation...
November 15, 2017: Poultry Science
https://www.readbyqxmd.com/read/29155210/transition-from-androgenic-to-neurosteroidal-action-of-5%C3%AE-androstane-3%C3%AE-17%C3%AE-diol-through-the-type-a-%C3%AE-aminobutyric-acid-receptor-in-prostate-cancer-progression
#15
Ding Xia, Doan V Lai, Weijuan Wu, Zachary D Webb, Qing Yang, Lichao Zhao, Zhongxin Yu, Jessica E Thorpe, Bryan C Disch, Michael A Ihnat, Muralidharan Jayaraman, Danny N Dhanasekaran, Kelly L Stratton, Michael S Cookson, Kar-Ming Fung, Hsueh-Kung Lin
Androgen ablation is the standard of care prescribed to patients with advanced or metastatic prostate cancer (PCa) to slow down disease progression. Unfortunately, a majority of PCa patients under androgen ablation progress to castration-resistant prostate cancer (CRPC). Several mechanisms including alternative intra-prostatic androgen production and androgen-independent androgen receptor (AR) activation have been proposed for CRPC progression. Aldo-keto reductase family 1 member C3 (AKR1C3), a multi-functional steroid metabolizing enzyme, is specifically expressed in the cytoplasm of PCa cells; and positive immunoreactivity of the type A γ-aminobutyric acid receptor (GABAAR), an ionotropic receptor and ligand-gated ion channel, is detected on the membrane of PCa cells...
November 15, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29151074/interferon-lambda-2-promotes-mammary-tumor-metastasis-via-angiogenesis-extension-and-stimulation-of-cancer-cell-migration
#16
R Pingwara, K Witt-Jurkowska, K Ulewicz, J Mucha, K Tonecka, Z Pilch, B Taciak, K Zabielska-Koczywas, M Mori, S Berardozzi, B Botta, T P Rygiel, M Krol
Myeloid-derived suppressor cells (MDSCs) support tumor development by stimulation of angiogenesis and immune response inhibition. In our previous study, we showed that interferon lambda 2 (IFN-λ2), secreted by MDSCs, enhances production of pro-angiogenic factors by cancer cells via phosphorylation of STAT3 and therefore promotes blood vessels formation. In the present study IFN-λ2 level was evaluated by ELISA in serum of tumor-bearing mice, whereas its expression in MDSCs isolated from the lungs with metastatic tumors and normal lungs was assessed by qPCR...
August 2017: Journal of Physiology and Pharmacology: An Official Journal of the Polish Physiological Society
https://www.readbyqxmd.com/read/29149662/in-ovo-transformation-of-two-emerging-flame-retardants-in-japanese-quail-coturnix-japonica
#17
Nathalie Briels, Mari E Løseth, Tomasz M Ciesielski, Govindan Malarvannan, Giulia Poma, Sara A Kjærvik, Alexis Léon, Ronan Cariou, Adrian Covaci, Veerle L B Jaspers
Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and Dechlorane Plus (DP) are two chlorinated, alternative flame retardants that have been found in wild birds and bird eggs. Little is known about the fate and effect of these compounds in birds, especially during the vulnerable stages of embryonic development. To investigate the ability of birds to biotransform these compounds, an in ovo exposure experiment with Japanese quail eggs was performed. Quail eggs were injected in the yolk sac with 1000ng/g egg of TDCIPP (2...
November 14, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29145689/-ultra-high-field-mri-in-the-chicken-embryo-in-ovo-a-model-for-experimental-ophthalmology
#18
Ronja Klose, Felix Streckenbach, Stefan Hadlich, Thomas Stahnke, Rudolf Guthoff, Andreas Wree, Marcus Frank, Sönke Langner, Oliver Stachs, Tobias Lindner
Ultra-high-field MRI (UHF-MRI) is an outstanding technique for non-invasive and non-destructive imaging of soft tissues and can provide versatile contrasts and high resolution in the µm range. In vivo imaging of the embryonal chick eye with its filigree anatomical structures imposes these requirements. However, due to the short embryonal development cycle, chicken are a favourite animal model for embryonal research studies. Ultra-high-field MRI allows repeated and longitudinal in ovo investigations on the same embryo...
November 16, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29134685/in-ovo-feeding-of-nutrients-and-its-impact-on-post-hatching-water-and-feed-deprivation-up-to-48%C3%A2-hr-energy-status-and-jejunal-morphology-of-chicks-using-response-surface-models
#19
M Ghanaatparast-Rashti, M Mottaghitalab, H Ahmadi
A Box-Behnken design (BBD) in a response surface methodology (RSM) was used to investigate the response of broiler chicks to in ovo feeding (IOF) of beta-hydroxy beta-methylbutyrate (HMB), dextrin and the timing of the first water and feed deprivation. On day 18th of incubation, 1,500 eggs were randomly assigned to 15 experimental runs of BBD, each with 4 replicates, as 3 levels IOF of HMB (0%, 0.5% and 1%) and dextrin (0%, 20% and 40%), and 3 levels of the first water and feed deprivation (6, 27 and 48 hr)...
November 13, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29126629/characterization-of-innate-responses-induced-by-in-ovo-administration-of-encapsulated-and-free-forms-of-ligands-of-toll-like-receptor-4-and-21-in-chicken-embryos
#20
Jegarubee Bavananthasivam, Tamiru N Alkie, Ayumi Matsuyama-Kato, Douglas C Hodgins, Shayan Sharif
Toll-like receptors (TLRs) are a family of innate receptors that recognize pathogen-associated molecular patterns, including double-stranded RNA, CpG DNA and lipopolysaccharide (LPS). After interaction with their ligands, TLRs initiate innate responses that are manifested by activating cells and inducing expression of cytokines that help mediate adaptive immune responses. TLR ligands (TLR-Ls) have the potential to be used prophylactically (alone) or as vaccine adjuvants to promote host immunity. Encapsulating TLR-Ls in nanoparticles, such as Poly (d,l-lactic-co-glycolic acid), may prolong responses through sustained release of the ligands...
October 25, 2017: Research in Veterinary Science
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