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https://www.readbyqxmd.com/read/29454536/the-role-of-the-ovol1-ovol2-axis-in-normal-and-diseased-human-skin
#1
REVIEW
Gaku Tsuji, Takamichi Ito, Takahito Chiba, Chikage Mitoma, Takeshi Nakahara, Hiroshi Uchi, Masutaka Furue
OVOLs (OVO-like proteins) are ubiquitously conserved genes encoding a C2 H2 zinc finger transcription factor in mammals. Functional studies on OVOL1 and OVOL2 using knockout mice have suggested that these genes play a pivotal role in the development of epithelial tissues arising from germ cells; however, the role of the OVOL1-OVOL2 axis in normal and diseased tissues remains unclear. This review highlights recent advances in understanding how the OVOL1-OVOL2 axis modulates cell differentiation and proliferation in human keratinocytes, hair follicles, and benign or malignant skin tumors including squamous cell carcinoma and malignant melanoma...
February 12, 2018: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29439287/demonstration-of-improved-tissue-integration-and-angiogenesis-with-an-elastic-estradiol-releasing-polyurethane-material-designed-for-use-in-pelvic-floor-repair
#2
Sarah Shafaat, Naside Mangir, Sabiniano R Regureos, Christopher R Chapple, Sheila MacNeil
AIMS: Pelvic organ prolapse and stress urinary incontinence affect 40-50% of postmenopausal women worldwide. Polypropylene meshes have been extensively used for the surgical intervention of these disorders; however, these meshes can lead to severe complications in some patients. The need for synthetic materials more suited for use in pelvic floor repair is widely accepted. This study aims to develop an electrospun 17-β-estradiol releasing polyurethane (PU) scaffold that not only provides the appropriate mechanical support but can also stimulate new extracellular matrix (ECM) production and angiogenesis...
February 13, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29432508/a-study-on-the-relationship-between-orthorexia-and-vegetarianism-using-the-bot-bratman-test-for-orthorexia
#3
Anna Dittfeld, Katarzyna Gwizdek, Paweł Jagielski, Joanna Brzęk, Katarzyna Ziora
OBJECTIVES: The following article presents the relationship between vegetarianism and orthorexia nervosa (ON). Vegetarianism is an ideology and a way of life that aims at minimizing animal exploitation. A vegetarian diet excludes the consumption of meat together with other animal derived products. According to scientists, orthorexia nervosa is considered to be a new, yet unclassified eating disorder. It involves introducing dietary restrictions by individuals who feel a desire to improve their health status by healthy eating...
December 30, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29431030/angiogenic-activity-of-human-adipose-derived-mesenchymal-stem-cells-under-simulated-microgravity
#4
Andrey Ratushnyy, Maria Ezdakova, Danila Yakubets, Ludmila Buravkova
Multipotent mesenchymal stem/stromal cells (MSCs) are strongly involved in tissue homeostasis mainly through paracrine regulation. Here we examined the influence of simulated microgravity on the angiogenic potential of adipose-derived MSCs (ASCs). The conditioned medium (CM) from RPM-exposed ASCs stimulated the formation of vessel network in ovo, endothelial cell (EC) capillary-like network ex ovo and non-directed EC migration in vitro. These effects were driven by alteration of both angiogenesis-related gene and protein expression...
February 12, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29427539/cholesterol-absorption-and-synthesis-in-vegetarians-and-omnivores
#5
Dieter Lütjohann, Sven Meyer, Klaus von Bergmann, Frans Stellaard
SCOPE: Vegetarian diets are considered health promoting, however, a plasma cholesterol lowering effect is not always observed. We investigated the link between vegetarian diet-induced alterations in cholesterol metabolism. METHODS AND RESULTS: We studied male and female omnivores, lacto-ovo vegetarians, lacto vegetarians and vegans. Cholesterol intake, absorption and fecal sterol excretion were measured as well as plasma concentrations of cholesterol and non-cholesterol sterols...
February 10, 2018: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/29427034/effect-of-in-ovo-zinc-injection-on-the-embryonic-development-and-epigenetics-related-indices-of-zinc-deprived-broiler-breeder-eggs
#6
Xiaoming Sun, Lin Lu, Xiudong Liao, Liyang Zhang, Xi Lin, Xugang Luo, Qiugang Ma
The role of in ovo zinc (Zn) injection in improving the embryonic development in eggs from Zn-deficient hens, via epigenetic and antioxidant mechanisms, was examined. A completely randomized design involving a 1 (the non-injected control) + 1 (the injected control with sterilized water) + 2 (Zn source) × 2 (Zn level) factorial arrangement of treatments was used. The two injected Zn sources were inorganic Zn sulfate and organic Zn-lysine chelate with a moderate chelation strength, and the two injected Zn levels were 50 and 100 μg Zn/egg...
February 9, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29422028/the-curious-case-of-peroxiredoxin-5-what-its-absence-in-aves-can-tell-us-and-how-it-can-be-used
#7
Marc Pirson, André Clippe, Bernard Knoops
BACKGROUND: Peroxiredoxins are ubiquitous thiol-dependent peroxidases that represent a major antioxidant defense in both prokaryotic cells and eukaryotic organisms. Among the six vertebrate peroxiredoxin isoforms, peroxiredoxin-5 (PRDX5) appears to be a particular peroxiredoxin, displaying a different catalytic mechanism, as well as a wider substrate specificity and subcellular distribution. In addition, several evolutionary peculiarities, such as loss of subcellular targeting in certain species, have been reported for this enzyme...
February 8, 2018: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29416857/glp1-and-gip-are-involved-in-the-action-of-synbiotics-in-broiler-chickens
#8
Pawel Antoni Kolodziejski, Maciej Sassek, Daniela Chalupka, Natalia Leciejewska, Leszek Nogowski, Pawel Mackowiak, Damian Jozefiak, Katarzyna Stadnicka, Maria Siwek, Marek Bednarczyk, Tomasz Szwaczkowski, Ewa Pruszynska-Oszmalek
Background: In order to discover new strategies to replace antibiotics in the post-antibiotic era in meat-type chicken production, two new synbiotics were tested: (Lactobacillus salivarius IBB3154 plus galactooligosaccharide (Syn1) and Lactobacillus plantarum IBB3036 plus raffinose family oligosaccharides (Syn2). Methods: The synbiotics were administered via syringe, using a special automatic system, into the egg air chamber of Cobb 500 broiler chicks on the 12th day of egg incubation (2 mg of prebiotics + 105 cfu bacteria per egg)...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29414859/the-assessment-of-bone-regulatory-pathways-bone-turnover-and-bone-mineral-density-in-vegetarian-and-omnivorous-children
#9
Jadwiga Ambroszkiewicz, Magdalena Chełchowska, Katarzyna Szamotulska, Grażyna Rowicka, Witold Klemarczyk, Małgorzata Strucińska, Joanna Gajewska
Vegetarian diets contain many beneficial properties as well as carry a risk of inadequate intakes of several nutrients important to bone health. The aim of the study was to evaluate serum levels of bone metabolism markers and to analyze the relationships between biochemical bone markers and anthropometric parameters in children on vegetarian and omnivorous diets. The study included 70 prepubertal children on a lacto-ovo-vegetarian diet and 60 omnivorous children. Body composition, bone mineral content (BMC), and bone mineral density (BMD) were assessed by dual-energy X-ray absorptiometry...
February 7, 2018: Nutrients
https://www.readbyqxmd.com/read/29408391/single-injection-ex-ovo-transplantation-method-for-broad-spinal-cord-engraftment-of-human-pluripotent-stem-cell-derived-motor-neurons
#10
Maria C Estevez-Silva, Akshitha Sreeram, Stephanie Cuskey, Nikolai Fedorchak, Nisha Iyer, Randolph S Ashton
BACKGROUND: Transplantation of human pluripotent stem cell (hPSC)-derived neurons into chick embryos is an established preliminary assay to evaluate engraftment potential. Yet, with recent advances in deriving diverse human neuronal subtypes, optimizing and standardizing such transplantation methodology for specific subtypes at their correlated anatomical sites is still required. NEW METHOD: We determined the optimal stage of hPSC-derived motor neuron (hMN) differentiation for ex ovo transplantation, and developed a single injection protocol that implants hMNs throughout the spinal cord enabling broad regional engraftment possibilities...
February 3, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29401234/expression-of-glucose-transporters-slc2a1-slc2a8-and-slc2a12-in-different-chicken-muscles-during-ontogenesis
#11
E Coudert, C Praud, J Dupont, S Crochet, E Cailleau-Audouin, T Bordeau, E Godet, A Collin, C Berri, S Tesseraud, S Métayer-Coustard
Glucose transport into cells is the first limiting step for the regulation of glucose homeostasis. In mammals, it is mediated by a family of facilitative glucose transporters (GLUTs) (encoded by SLC2A* genes), with a constitutive role (GLUT1), or insulin-sensitive transporters (GLUT4, GLUT8 and GLUT12). Compared to mammals, the chicken shows high levels of glycaemia and relative insensitivity to exogenous insulin. To date, only GLUT1, -8 and -12 have been described in chicken skeletal muscles but not fully characterized, whereas GLUT4 was reported as lacking...
February 1, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/29394105/down-regulation-of-transcription-factor-ovol2-contributes-to-epithelial-mesenchymal-transition-in-a-noninvasive-type-of-trophoblast-implantation-to-the-maternal-endometrium
#12
Rulan Bai, Kazuya Kusama, Keigo Nakamura, Toshihiro Sakurai, Koji Kimura, Atsushi Ideta, Yoshito Aoyagi, Kazuhiko Imakawa
Embryo implantation into the uterine endometrium is required for pregnancy establishment in most mammals. By using global expression analysis, we investigated the molecules that are related to epithelial-mesenchymal transition (EMT) in noninvasive bovine trophoblasts and found that the transcription factor, ovo-like zinc finger 2 ( OVOL2), which is essential for mesenchymal-epithelial transition in various cancers, was down-regulated after trophoblast attachment to the endometrial epithelium in utero. In cultured bovine trophoblast cells, OVOL2 down-regulation occurred only when cells were allowed to attach to bovine endometrial epithelial cells via the TEAD3/YAP signaling pathway...
February 2, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29393271/phenotypic-variation-in-46-xx-disorders-of-sex-development-due-to-the-nr5a1-p-r92w-variant-a-sibling-case-report-and-literature-review
#13
Kei Takasawa, Maki Igarashi, Makoto Ono, Akira Takemoto, Shuji Takada, Atsuyuki Yamataka, Tsutomu Ogata, Tomohiro Morio, Maki Fukami, Kenichi Kashimada
Recently, a heterozygous missense mutation in NR5A1, p.R92W, was identified as a cause of 46,XX testicular/ovo-testicular disorders of sexual development (DSD). We report a sibling pair with 46,XX DSD due to an NR5A1 mutation with distinct phenotypes, including external and internal genitalia and gonads, for whom different rearing sexes were selected. Thus, the phenotypes of p.R92W vary, even within a family. The father of the patients showed oligozoospermia with the p.R92W mutation, suggesting that in 46,XY individuals, the mutation would cause various gonadal phenotypes...
January 24, 2018: Sexual Development: Genetics, Molecular Biology, Evolution, Endocrinology, Embryology, and Pathology of Sex Determination and Differentiation
https://www.readbyqxmd.com/read/29382895/incubation-temperature-affects-the-expression-of-young-precocial-birds-fear-related-behaviours-and-neuroendocrine-correlates
#14
Aline Bertin, Ludovic Calandreau, Maryse Meurisse, Marion Georgelin, Rupert Palme, Sophie Lumineau, Cécilia Houdelier, Anne-Sophie Darmaillacq, Ludovic Dickel, Violaine Colson, Fabien Cornilleau, Christophe Rat, Joel Delaveau, Cécile Arnould
The influence of embryonic microclimate on the behavioural development of birds remains unexplored. In this study, we experimentally tested whether chronic exposure to suboptimal temperatures engendered plasticity in the expression of fear-related behaviours and in the expression of the corticotropin-releasing factor in the brains of domestic chicks (Gallus g. domesticus). We compared the neurobehavioural phenotypes of a control group of chicks incubated in an optimal thermal environment (37.8 °C) with those of a group of experimental chicks exposed chronically in ovo to suboptimal temperatures (27...
January 30, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29382549/human-tubb3-mutations-disrupt-netrin-attractive-signaling
#15
Huai Huang, Tao Yang, Qiangqiang Shao, Tanushree Majumder, Kristopher Mell, Guofa Liu
Heterozygous missense mutations in human TUBB3 gene result in a spectrum of brain malformations associated with defects in axon guidance, neuronal migration and differentiation. However, the molecular mechanisms underlying mutation-related axon guidance abnormalities are unclear. Recent studies have shown that netrin-1, a canonical guidance cue, induced the interaction of TUBB3 with the netrin receptor deleted in colorectal cancer (DCC). Furthermore, TUBB3 is required for netrin-1-induced axon outgrowth, branching and pathfinding...
January 27, 2018: Neuroscience
https://www.readbyqxmd.com/read/29374439/1st-inexo-symposium-alternative-models-in-vitro-ex-ovo-and-organisms-from-research-to-applications-in-pathologies-and-aging
#16
EDITORIAL
Philippe Nirdé, Myriam Richaud, Hinda Dabboue, Jean-Pierre Reynier, Simon Galas, Laure-Anaïs Vincent, Jean-Pierre Moles, Gilberte Marti-Mestres, Paul Chambon
No abstract text is available yet for this article.
2018: ALTEX
https://www.readbyqxmd.com/read/29366709/recombinant-live-attenuated-avian-coronavirus-vaccines-with-deletions-in-the-accessory-genes-3ab-and-or-5ab-protect-against-infectious-bronchitis-in-chickens
#17
Steven J van Beurden, Alinda J Berends, Annika Krämer-Kühl, Dieuwertje Spekreijse, Gilles Chenard, Hans-Christian Philipp, Egbert Mundt, Peter J M Rottier, M Hélène Verheije
Avian coronavirus infectious bronchitis virus (IBV) is a respiratory pathogen of chickens, causing severe economic losses in poultry industry worldwide. Live attenuated viruses are widely used in both the broiler and layer industry because of their efficacy and ability to be mass applied. Recently, we established a novel reverse genetics system based on targeted RNA recombination to manipulate the genome of IBV strain H52. Here we explore the possibilities to attenuate IBV in a rational way in order to generate safe and effective vaccines against virulent IBV (van Beurden et al...
January 20, 2018: Vaccine
https://www.readbyqxmd.com/read/29363583/ephexin1-is-required-for-eph-mediated-limb-trajectory-of-spinal-motor-axons
#18
Chih-Ju Chang, Ming-Yuan Chang, Szu-Yi Chou, Chi-Chen Huang, Jian-Ying Chuang, Tsung-I Hsu, Hsing-Fang Chang, Yi-Hsin Wu, Chung-Che Wu, Daniel Morales, Artur Kania, Tzu-Jen Kao
The precise assembly of a functional nervous system relies on the guided migration of axonal growth cones, which is made possible by signals transmitted to the cytoskeleton by cell surface-expressed guidance receptors. We investigated the function of ephexin1, a Rho guanine nucleotide exchange factor, as an essential growth cone guidance intermediary in the context of spinal lateral motor column (LMC) motor axon trajectory selection in the limb mesenchyme. Using in situ mRNA detection, we first show that ephexin1 is expressed in LMC neurons of chick and mouse embryos at the time of spinal motor axon extension into the limb...
January 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29357278/social-factors-and-aromatase-gene-expression-during-adult-male-to-female-sex-change-in-captive-leopard-grouper-mycteroperca-rosacea
#19
Daniel Romo-Mendoza, Rafael Campos-Ramos, Grecia Vázquez-Islas, Mario A Burgos-Aceves, Edgar R Esquivel-Gutiérrez, Danitzia A Guerrero-Tortolero
Social factors and aromatase gene expression in the leopard grouper Mycteroperca rosacea was studied when captive fish were separated by sex during the reproductive (April-June) and post-reproductive (July-September) seasons. Monosex females, monosex males, and mixed-sex, held in social sextet units were analyzed for sex steroids throughout confinement. At the end of the experiment, the gonad-sex was defined by histology, and gonad and brain aromatase gene expressions were quantified. Only males held in the monosex social units changed sex...
January 18, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29352028/the-mysteries-of-remote-memory
#20
REVIEW
Zimbul Albo, Johannes Gräff
Long-lasting memories form the basis of our identity as individuals and lie central in shaping future behaviours that guide survival. Surprisingly, however, our current knowledge of how such memories are stored in the brain and retrieved, as well as the dynamics of the circuits involved, remains scarce despite seminal technical and experimental breakthroughs in recent years. Traditionally, it has been proposed that, over time, information initially learnt in the hippocampus is stored in distributed cortical networks...
March 19, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
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