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Living donor liver transplant

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https://www.readbyqxmd.com/read/29649828/risk-analysis-for-invasive-fungal-infection-after-living-donor-liver-transplantation-which-patient-needs-potent-prophylaxis
#1
Masashi Utsumi, Yuzo Umeda, Takahito Yagi, Takeshi Nagasaka, Susumu Shinoura, Ryuich Yoshida, Daisuke Nobuoka, Takashi Kuise, Tomokazu Fuji, Kosei Takagi, Akinobu Takaki, Toshiyoshi Fujiwara
BACKGROUND: Invasive fungal infection (IFI) is associated with high mortality after living donor liver transplant (LDLT). The aim of this study was to identify the risk factors for post-LDLT IFI for early diagnosis and improvement of antifungal treatment outcome. METHODS: Risk analysis data were available for all 153 patients who underwent LDLT between January 2005 and April 2012. RESULTS: During the follow-up period (1,553 ± 73 days, range 20-2,946 days), 15 patients (9...
April 12, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29649247/serum-interleukin-6-and-tumor-necrosis-factor-%C3%AE-are-associated-with-early-graft-regeneration-after-living-donor-liver-transplantation
#2
Min Suk Chae, Kwang Uck Moon, Hyun Sik Chung, Chul Soo Park, Jaemin Lee, Jong Ho Choi, Sang Hyun Hong
BACKGROUND: Liver graft regeneration is orchestrated by specific and sequential stimuli, including hepatocyte growth factors, cytokines, and catecholamines. We evaluated the association between preoperative serum cytokines and early liver graft regeneration in human living donor liver transplantation (LDLT). PATIENTS AND METHODS: We retrospectively reviewed the data of adult patients who underwent LDLT from January 2010 to December 2014. Serum cytokines, including interleukin (IL)-2, 6, 10, 12, 17, interferon (IFN)-γ and tumor necrosis factor (TNF)-α were measured in the recipients 1 day before surgery and on postoperative day (POD) 7...
2018: PloS One
https://www.readbyqxmd.com/read/29629357/living-donor-liver-transplantation-prior-to-multiple-myeloma-treatment-in-a-patient-with-hepatitis-b-associated-hepatocellular-carcinoma-and-liver-cirrhosis-a-case-report
#3
Chan Woo Cho, Nuri Lee, Gyu-Seong Choi, Jong Man Kim, Choon Hyuck David Kwon, Jae-Won Joh
Clinical outcomes of living donor liver transplantation (LDLT) for hepatocellular carcinoma (HCC) in patients with multiple myeloma (MM) have not been established in terms of HCC recurrence and MM deterioration after LDLT. A 51-year-old man with chronic hepatitis B was diagnosed with HCC and MM. Since the patient also had decompensated liver cirrhosis (LC), he underwent LDLT prior to autologous peripheral blood stem cell transplantation (PBSCT) to prevent fulminant hepatitis due to HBV reactivation. The patient received Epstein-Barr virus prophylaxis and a triple immunosuppressive regimen of tacrolimus, everolimus, and steroid after LDLT...
April 2018: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/29623268/the-new-era-of-transplant-oncology-liver-transplantation-for-nonresectable-colorectal-cancer-liver-metastases
#4
REVIEW
Andre Gorgen, Hala Muaddi, Wei Zhang, Ian McGilvray, Steven Gallinger, Gonzalo Sapisochin
Colorectal cancer (CRC) is the third most incident cancer worldwide. Most of CRC patients will develop distant metastases, mainly to the liver, and liver resection is the only potential chance for cure. On the other hand, only a small proportion of patients with hepatic CRC metastasis are candidates for upfront liver resection. Liver transplantation (LT) is an attractive option for patients with nonresectable CRC liver metastases (NRCLM) without extrahepatic involvement. Initial experiences with LT for NRCLM achieved very poor outcomes, with a 5-year overall survival (OS) lower than 20%...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29621060/prediction-of-the-development-of-persistent-massive-ascites-after-living-donor-liver-transplantation-using-a-perioperative-risk-score
#5
Yi-Ju Wu, Shih-Ho Wang, Ahmed M Elsarawy, Yi-Chia Chan, Chao-Long Chen, Ben-Chung Cheng, Lung-Chi Li, Chien-Hua Chiu, Yi-Wei Lee, Yu-Cheng Lin, Sin-Yong Wee, Cheng-Chung Pan, Yu-Yin Kao, Ying-Hsiu Chen, Hsiao-Wen Lin, Li-Man Lin, Chih-Che Lin
BACKGROUND: Persistent massive ascites (PMAS) >14 days after living donor liver transplantation (LDLT) is not uncommon and associated with worse outcome. A predictive risk scoring system was constructed after analysis of recipient, graft and surgery related factors. METHODS: We retrospectively reviewed adult LDLT recipients from 2005 to 2011 after excluding cases that experienced any intervention for perioperative vascular-related events. Two groups were identified; PMAS and non-PMAS...
April 5, 2018: Transplantation
https://www.readbyqxmd.com/read/29621008/incidence-and-clinical-significance-of-hyperfibrinolysis-during-living-donor-liver-transplantation
#6
Eun-Hee Kim, Justin S Ko, Mi-Sook Gwak, Suk-Koo Lee, Gaab-Soo Kim
: We evaluated the incidence and clinical significance of hyperfibrinolysis during living donor liver transplantation (LDLT) using viscoelastic coagulation tests. We retrospectively reviewed adult LDLT recipients from February 2010 to February 2015. Hyperfibrinolysis was defined when clot lysis index [LY60 = (MA - A60)/MA × 100, %] was less than 85, where A60 is the clot amplitude at 60 min after maximum amplitude (MA) occurred. Viscoelastic coagulation tests were performed six times (T1: immediately after anesthetic induction, T2: end of preanhepatic phase, T3: 1 h after anhepatic phase, T4: 5 min after reperfusion, T5: 1 h after reperfusion, and T6: 3 h after reperfusion)...
April 4, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29620615/long-term-outcomes-of-abo-incompatible-pediatric-living-donor-liver-transplantation
#7
Masaki Honda, Yasuhiko Sugawara, Masashi Kadohisa, Keita Shimata, Masataka Sakisaka, Daiki Yoshii, Keiichi Uto, Shintaro Hayashida, Yuki Ohya, Hidekazu Yamamoto, Hirotoshi Yamamoto, Yukihiro Inomata, Taizo Hibi
BACKGROUND: ABO-incompatible (ABOi) living donor liver transplantation (LDLT) have been performed to compensate for donor shortage. To date, few studies have reported detailed B cell desensitization protocols and long-term outcomes of ABOi pediatric LDLT. METHODS: Twenty-nine pediatric ABOi LDLT recipients were retrospectively analyzed. We compared the clinical outcomes between ABOi (n = 29) and non-ABOi (n = 131) pediatric LDLT recipients. Furthermore, we evaluated the safety and efficacy of our rituximab-based regimen for ABOi pediatric LDLT (2 ≤ age < 18, n = 10)...
April 3, 2018: Transplantation
https://www.readbyqxmd.com/read/29610975/prognostic-factors-for-long-term-survival-after-adult-liver-transplantation
#8
Soufiane Filali Bouami, Jill Gwiasda, Jan Beneke, Alexander Kaltenborn, Sebastian Liersch, Eduardo M Suero, Hans-Friedrich Koch, Christian Krauth, Jürgen Klempnauer, Harald Schrem
PURPOSE: Prognostic factors for survival ≥ 15 years and life years lost after liver transplantation are largely unknown. METHODS: One thousand six hundred thirty primary adult liver transplants between 1983 and 2014 were analyzed. Risk factors for survival were identified with multivariable Cox regression and subsequently tested for their relevance as prognostic factors for observed 15-year survival using multivariable logistic regression and c statistics. The difference of life expectancy between a matched national reference population and survival in patients with post-transplant survival ≥ 15 years was calculated...
April 2, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29607424/preoperative-evaluation-of-liver-volume-in-living-donor-liver-transplantation
#9
Adil Baskiran, Aysegul Sagir Kahraman, Ipek Balikci Cicek, Tolga Sahin, Burak Isik, Sezai Yilmaz
OBJECTIVE: The aim of the present study was to retrospectively evaluate the difference between the preoperative estimated volume and the actual intraoperative graft volume determined in donor right hepatectomies and to evaluate the possible effect of age, gender, and body mass index on the difference. METHODS: A total of 225 donor hepatectomies performed at the center between 2016 and 2017 were evaluated for the study. Left hepatectomies and left lateral segmentectomies were excluded from the analysis...
2018: Northern Clinics of Istanbul
https://www.readbyqxmd.com/read/29604237/expanding-the-donor-pool-donation-after-circulatory-death-and-living-liver-donation-does-not-compromise-the-results-of-liver-transplantation
#10
Dagmar Kollmann, Gonzalo Sapisochin, Nicolas Goldaracena, Bettina E Hansen, Ramraj Rajakumar, Nazia Selzner, Mamatha Bhat, Stuart McCluskey, Mark S Cattral, Paul D Greig, Les Lilly, Ian D McGilvray, Anand Ghanekar, David R Grant, Markus Selzner
By cause of the shortfall between the number of patients listed for liver transplantation (LT) and available grafts, strategies to expand the donor pool have been developed. Donation after Circulatory Death (DCD) and Living donor (LD) grafts are not universally used due to the concerns of graft failure, biliary complications and donor risks. In order to overcome the barriers for the implementation of using all three types of grafts, we compared outcomes after LT of DCD, LD and donation after brain death (DBD) grafts...
March 31, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29604232/clinical-course-of-hepatic-artery-thrombosis-after-living-donor-liver-transplantation-using-the-right-lobe
#11
Ho Joong Choi, Dong Goo Kim, Yumi Kim, Bong Jun Kwak, Jae Hyun Han, Tae Ho Hong, Young Kyoung You
Background Hepatic artery thrombosis (HAT) can result in biliary tree necrosis and graft loss necessitating re-transplantation. The most effective treatment approach is still controversial. This study was performed to review the outcomes of HAT after living donor liver transplantation (LDLT), and to clarify the feasibility of different strategies. Methods From May 1996 to August 2017, LDLT using the right lobe was performed in 827 adult patients in our center. Our technique of hepatic artery (HA) reconstruction is end-to-end anastomosis under a microscope (× 10)...
March 31, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29596092/the-impact-of-postreperfusion-syndrome-on-acute-kidney-injury-in-living-donor-liver-transplantation-a-propensity-score-analysis
#12
In-Gu Jun, Hye-Mee Kwon, Kyeo-Woon Jung, Young-Jin Moon, Won-Jung Shin, Jun-Gol Song, Gyu-Sam Hwang
BACKGROUND: Postreperfusion syndrome (PRS) has been shown to be related to postoperative morbidity and graft failure in orthotopic liver transplantation. To date, little is known about the impact of PRS on the prevalence of postoperative acute kidney injury (AKI) and the postoperative outcomes after living donor liver transplantation (LDLT). The purpose of our study was to determine the impact of PRS on AKI and postoperative outcomes after LDLT surgery. METHODS: Between January 2008 and October 2015, we retrospectively collected and evaluated the records of 1865 patients who underwent LDLT surgery...
March 27, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29594724/kinetics-of-liver-regeneration-in-donors-after-living-donor-liver-transplantation-a-retrospective-analysis-of-2-3rd-partial-hepatectomy-model-at-3-months
#13
Shailesh Anand Sable, Sharad Maheshwari, Swapnil Sharma, Kapildev Yadav, Ashutosh Chauhan, Sorabh Kapoor, Vibha Varma, Vinay Kumaran
BACKGROUND/AIM: Right lobe living donor (2/3rd partial hepatectomy) model is the best way to accurately study liver regeneration process in human beings. We aimed to study the kinetics of liver regeneration after 2/3rd partial hepatectomy in donors. METHODS: Retrospective analysis of prospectively maintained volumetric recovery data in donors was performed in 23 donors, who underwent 29 contrast-enhanced computed tomography within 3 months for various clinical indications...
March 29, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29594195/effects-of-infection-on-post-transplant-outcomes-living-versus-deceased-donor-liver-transplants
#14
Osama Siddique, Ayesha S Siddique, Jason T Machan, Kittichai Promrat
Introduction: Post-transplant infections have been studied widely but data on comparisons of deceased donor liver transplants (DDLT) and living donor liver transplants (LDLT), type and timings of infections, and their relations to outcomes are not explored. Material and methods: We analysed data from 612 participants of the Adult-to-Adult Living Donor Liver Transplantation Study (A2ALL), a retrospective data set of LDLT and DDLT. We compared the type and timing of the first post-transplant infection in relation to transplant outcomes between the two groups...
March 2018: Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29594166/robot-assisted-transplant-surgery-vision-or-reality-a-comprehensive-review
#15
REVIEW
Philipp Stiegler, Peter Schemmer
Minimally invasive surgery is standard procedure for many operations. Further refinements include the introduction of robotic surgery which is still an emerging field especially in laparoscopic surgery. Since the successful introduction of the da Vinci Robotic Surgical System, the robotic approach in organ transplantation has become of great interest in both the live donor organ retrieval and the recipient operation. Robotic surgery for kidney, liver, and pancreas transplantation is feasible. Over 700 donor nephrectomies and 100 kidney transplantations have been performed already, and robotic surgery is standard in a small number of pioneer centers; however, larger series and most importantly randomized controlled trials for the highest evidence are needed...
February 2018: Visceral Medicine
https://www.readbyqxmd.com/read/29582006/what-s-mine-is-yours-long-term-experiences-of-good-samaritan-organ-donors
#16
Katrina A Bramstedt
This study is a long-term follow-up on the health and quality of life of Good Samaritan living organ donors who donated an average of 10 years ago. Thirteen donors (kidney, liver, and lung) completed 2 surveys. Data from the RAND 36-Item Health Survey showed that for all domains, as well as the physical and mental component summary scales, the Good Samaritan donor outcomes were superior to the general population ( P < .0001). Data from the European Living Donor Satisfaction Survey (EULID) showed that in all 8 theme areas, the donors reported statistically significant positive reactions as compared to negative reactions...
March 2018: Journal of Patient Experience
https://www.readbyqxmd.com/read/29580036/clinical-implication-of-hepatic-volumetry-for-living-donor-liver-transplantation
#17
Woo Kyoung Jeong
No abstract text is available yet for this article.
March 2018: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/29577436/preformed-donor-specific-antibodies-do-not-affect-the-one-year-allograft-survival-in-living-donor-liver-transplantation
#18
Hyeyoung Kim, Nam-Joon Yi, Eun Young Song, Kyoungbun Lee, Kwang-Woong Lee, Hae Won Lee, Hye Young Ahn, Kyung Chul Yoon, Suk Kyun Hong, Kyung-Suk Suh
The effect of preformed donor-specific antibodies (DSAs) on liver transplantation (LT) remains unclear, especially in the field of living donor LT (LDLT). Herein, we evaluated the prevalence of preformed DSAs and their effect on graft outcome in LDLT in the first year following surgery. Using the Luminex® Single Antigen assay, we analyzed the preoperative sera of 61 adult LDLT recipients between 2014 and 2015. Clinical outcomes and pathologic findings including complement component 4d (C4d) expression in the first year after LT were retrospectively reviewed...
March 26, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29576278/a-comparison-of-desensitization-methods-rituximab-with-without-plasmapheresis-in-abo-incompatible-living-donor-liver-transplantation
#19
Eung Chang Lee, Seong Hoon Kim, Jae Ryong Shim, Sang-Jae Park
BACKGROUND: Plasmapheresis is a desensitization method used prior to ABO-incompatible (ABO-I) living donor liver transplantation. However, studies on its usefulness in the rituximab era are lacking. METHODS: Fifty-six adult patients underwent ABO-I living donor liver transplantation between January 2012 and October 2015. A single dose of rituximab (300 mg/m2 ) was administered 2 weeks before surgery with plasmapheresis in all patients until February 2014 (RP group, n = 26)...
February 19, 2018: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/29575841/-clinical-application-of-ldlt-after-reconstruction-of-ivc-using-artificial-blood-vessel-in-the-treatment-of-hcc-beyond-milan-criteria
#20
B C Sun, G Q Li, X L Huang, J J Qin, X X Mu
Objective: To assess application of reconstruction of retrohepatic inferior vena cava using artificial blood vessel in right lobe living donor liver transplantation (LDLT) in the treatment of hepatocellular carcinoma (HCC) beyond Milan Criteria. Methods: The clinical data of 9 HCC patients who underwent right lobe liver transplantation after reconstruction of retrohepatic inferior vena cava using artificial blood vessel between June 2015 and Nov 2016 at Liver Transplantation Center of the First Affiliated Hospital of Nanjing Medical University were retrospectively analyzed...
March 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
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