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https://www.readbyqxmd.com/read/28343188/multimodal-evoked-potentials-in-patients-with-multiple-sclerosis-in-assessment-of-the-course-of-the-disease
#1
Beata Łabuz-Roszak, Magdalena Torbus, Katarzyna Kubicka-Bączyk, Agnieszka Machowska-Majchrzak, Agata Kierber, Katarzyna Borucka, Małgorzata Zellner, Anna Starostak-Tatar, Krystyna Pierzchała
INTRODUCTION: Multiple sclerosis (MS) is a chronic inflammatory, demyelinating disease of the central nervous system with a multifocal damage. THE AIM: The assessment of the MS course by multimodal evoked potentials (EP). MATERIAL AND METHODS: We evaluated 95 patients (63 female, 32 male) with relapsing-remitting MS in the average age of 36.4±10.4. The average disease duration was 4.6±7.4 year. Among them, 48 patients (50.5%) were treated with immunomodulatory drugs...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28342828/-resistance-training-for-muscle-weakness-in-multiple-sclerosis-direct-versus-contralateral-approach-in-individuals-with-ankle-dorsiflexors-disparity-in-strength
#2
Andrea Manca, Maria Paola Cabboi, Daniele Dragone, Francesca Ginatempo, Enzo Ortu, Edoardo Rosario De Natale, Beniamina Mercante, Giovanni Mureddu, Guido Bua, Franca Deriu
OBJECTIVE: To compare effects of contralateral strength training (CST) versus direct strength training (DST) of the more-affected ankle dorsiflexors on muscle performance and clinical-functional outcomes in people with multiple sclerosis (MS) exhibiting inter-limb strength asymmetry. DESIGN: Randomized controlled trial PARTICIPANTS: Individuals with relapsing-remitting MS and mild-to-moderate disability (EDSS≤6) presenting with ankle dorsiflexors' strength disparity...
March 22, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28336344/participation-restriction-in-people-with-multiple-sclerosis-prevalence-and-correlations-with-cognitive-walking-balance-and-upper-limb-impairments
#3
Davide Cattaneo, Ilse Lamers, Rita Bertoni, Peter Feys, Johanna Jonsdottir
OBJECTIVE: To calculate percentage of participation restrictions according to disability level in Multiple Sclerosis (MS) and to assess relationship between participation restriction, and cognitive, gait, balance and upper limb deficits. DESIGN: Cross sectional study SETTING: Rehabilitation unit PARTICIPANTS: 105 people with MS and 20 healthy subjects (HS) were screened in Belgium and Italy. INTERVENTIONS: Not applicable MAIN OUTCOME MEASURES: The Community integration questionnaire was used to assess participation in Home, Social and Productive Activities...
March 21, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28320165/hla-genotype-as-a-marker-of-multiple-sclerosis-prognosis-a-pilot-study
#4
Andreas P Lysandropoulos, Nicolas Mavroudakis, Massimo Pandolfo, Kaoutar El Hafsi, Wim van Hecke, Anke Maertens, Thibo Billiet, Annemie Ribbens
OBJECTIVE: The identification of a biomarker with prognostic value is an unmet need in multiple sclerosis (MS). The objective of this study was to investigate a possible association of HLA genotype with disease status and progression in MS, based on comprehensive and sensitive clinical and magnetic resonance imaging (MRI) parameters to measure disease effects. METHOD: A total of 118 MS patients (79 females, 39 males) underwent HLA typing. Patient MS status was assessed at two time points in a 2-year interval, based on clinical scores (including EDSS, MSSS, T25FW, 9-HPT, SDMT, BVMT, CVLT-II) and MRI evaluations...
April 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28319417/alterations-in-serum-levels-of-il-17-in-contrast-to-tnf-alpha-correspond-to-disease-modifying-treatment-in-relapsing-remitting-multiple-sclerosis
#5
Anastasiya Georgieva Trenova, Georgi Svetoslavov Slavov, Maria Georgieva Manova, Milena Nenkova Draganaova-Filipova, Nonka Georgieva Mateva, Lyuba Dineva Miteva, Spaska Angelova Stanilova
Cytokines of different types play an important role in multiple sclerosis (MS) pathogenesis as mediators and regulators of the immune processes in the central nervous system. The aim of the study was to determine the effect of interferon-beta and glatiramer acetate on serum concentrations of TNF-alpha and IL-17 A and their correlation with the degree of disability in clinically stable patients with relapsing-remitting MS. A cross-sectional, case-control study of 220 patients (68 treatment naïve; 152 treated with interferon-beta or glatiramer acetate) and 99 clinically healthy age-gender-body mass index-matched subjects were performed...
March 20, 2017: Scandinavian Journal of Clinical and Laboratory Investigation
https://www.readbyqxmd.com/read/28318794/ethylenediaminedisuccinic-acid-edds-enhances-phytoextraction-of-lead-by-vetiver-grass-from-contaminated-residential-soils-in-a-panel-study-in-the-field
#6
Ramesh Attinti, Kirk R Barrett, Rupali Datta, Dibyendu Sarkar
Phytoextraction is a green remediation technology for cleaning contaminated soils. Application of chelating agents increases metal solubility and enhances phytoextraction. Following a successful greenhouse experiment, a panel study under field weather elucidated the efficiency of the chelating agent ethylenediaminedisuccinic acid (EDDS) on phytoextraction of lead (Pb) by vetiver grass, a hyperaccumulator of Pb, and a nonaccumulator fescue grass from residential soils contaminated with Pb-based paint from Baltimore, MD and San Antonio, TX...
March 16, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28301287/spinal-cord-lesions-a-modest-contributor-to-diagnosis-in-clinically-isolated-syndromes-but-a-relevant-prognostic-factor
#7
Georgina Arrambide, Alex Rovira, Jaume Sastre-Garriga, Carmen Tur, Joaquín Castilló, Jordi Río, Angela Vidal-Jordana, Ingrid Galán, Breogán Rodríguez-Acevedo, Luciana Midaglia, Carlos Nos, Patricia Mulero, Maria Jesús Arévalo, Manuel Comabella, Elena Huerga, Cristina Auger, Xavier Montalban, Mar Tintore
BACKGROUND: The usefulness of performing a spinal cord (SC) magnetic resonance imaging (MRI) in all clinically isolated syndromes (CIS) is controversial. OBJECTIVE: To assess the value of SC lesions for predicting multiple sclerosis (MS) diagnosis and disability accrual in CIS. METHODS: Concerning SC lesions and MS diagnosis (2010 McDonald), adjusted Cox regression analyses were performed in increasingly specific CIS groups: all cases ( n = 207), non-SC CIS ( n = 143), non-SC CIS with abnormal brain MRI ( n = 90) and non-SC CIS with abnormal brain MRI not fulfilling 2010 MS ( n = 67)...
March 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28287331/disability-progression-markers-over-6-12%C3%A2-years-in-interferon-%C3%AE-treated-multiple-sclerosis-patients
#8
Jordi Río, Àlex Rovira, Mar Tintoré, Susana Otero-Romero, Manuel Comabella, Ángela Vidal-Jordana, Ingrid Galán, Joaquín Castilló, Georgina Arrambide, Carlos Nos, Carmen Tur, Berta Pujal, Cristina Auger, Jaume Sastre-Garriga, Xavier Montalban
OBJECTIVE: To investigate the association between activity during interferon-beta (IFNβ) therapy and disability outcomes in patients with relapsing-remitting multiple sclerosis (RRMS). METHODS: A longitudinal study based on two previously described cohorts of IFNβ-treated RRMS patients was conducted. Patients were classified according to clinical activity after 2 years (clinical cohort) or to clinical and radiological activity after 1 year (magnetic resonance imaging (MRI) cohort)...
March 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28283107/sexual-dysfunction-levels-in-iranian-women-suffering-from-multiple-sclerosis
#9
Nahid Dehghan-Nayeri, Zohreh Khakbazan, Faezeh Ghafoori, Seyed Massood Nabavi
OBJECTIVE: Sexual dysfunction (SD) is a common complaint in women who suffer from Multiple Sclerosis (MS), which has been categorized in three levels (primary, secondary, and tertiary) in previous studies. This study was conducted to assess the prevalence of sexual dysfunction (SD) at each level, and to identify associated factors and their impacts on SD in married women who suffer from Multiple Sclerosis. This study was conducted in Iran where the cultural barriers are recognized as important challenges in sexual function...
February 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28282574/long-term-effectiveness-and-safety-of-natalizumab-in-a-portuguese-population
#10
I Correia, S Batista, O Galego, I B Marques, J Jesus-Ribeiro, A I Martins, C Nunes, M C Macário, L Cunha, L Sousa
OBJECTIVES: Natalizumab long-term effectiveness data in real-world relapsing-remitting multiple sclerosis (RRMS) is needed. Our objective is to report the long-term effectiveness and safety of natalizumab in a cohort of RRMS patients. METHODS: This is a retrospective study of natalizumab treatment for two years or longer in RRMS. Annualized relapse rate, Expanded Disability Status Scale (EDSS), brain magnetic resonance imaging T2 lesion volume, JC virus antibody status, previous treatments and adverse events were analysed...
March 7, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28273778/the-impact-of-subjective-cognitive-fatigue-and-depression-on-cognitive-function-in-patients-with-multiple-sclerosis
#11
Daniel Golan, Glen M Doniger, Karl Wissemann, Myassar Zarif, Barbara Bumstead, Marijean Buhse, Lori Fafard, Idit Lavi, Jeffrey Wilken, Mark Gudesblatt
BACKGROUND: The association between subjective cognitive fatigue and objective cognitive dysfunction in patients with multiple sclerosis (PwMS) has been studied, with conflicting results. OBJECTIVE: To explore the impact of fatigue on cognitive function, while controlling for the influence of depression, disability, comorbidities, and psychotropic medications. METHODS: PwMS completed a computerized cognitive testing battery with age- and education-adjusted cognitive domain scores...
February 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28261936/characterizing-clinical-and-mri-dissociation-in-patients-with-multiple-sclerosis
#12
Brian C Healy, Guy J Buckle, Eman N Ali, Svetlana Egorova, Fariha Khalid, Shahamat Tauhid, Bonnie I Glanz, Tanuja Chitnis, Charles R G Guttmann, Howard L Weiner, Rohit Bakshi
BACKGROUND AND PURPOSE: Two common approaches for measuring disease severity in multiple sclerosis (MS) are the clinical exam and brain magnetic resonance imaging (MRI) scan. Although most patients show similar disease severity on both measures, some patients have clinical/MRI dissociation. METHODS: Subjects from a comprehensive care MS center who had a concurrent brain MRI, spinal cord MRI, clinical examination, and patient reported outcomes were classified into three groups based on the Expanded Disability Status Scale (EDSS) and cerebral T2 hyperintense lesion volume (T2LV)...
March 6, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/28253538/the-identification-of-upregulated-ebv-mir-bhrf1-2-5p-targeting-malt1-and-ebv-mir-bhrf1-3-in-the-circulation-of-patients-with-multiple-sclerosis
#13
Yifei Wang, Dandan He, Hongwei Liang, Dan Yang, Hui Yue, Xuemei Zhang, Rui Wang, Bing Li, Hongxia Yang, Yuan Liu, Yao Chen, Yuxiao Duan, ChenYu Zhang, Xi Chen, Jin Fu
Epstein-Barr virus (EBV) is a well-documented etiologic factor for multiple sclerosis (MS). EBV encodes at least 44 microRNAs (miRNAs) that are readily detectable in the circulation of human. Previous studies have demonstrated that EBV-encoded miRNAs regulate host immune response and may serve as biomarkers for EBV-associated diseases. However, the roles of EBV miRNAs in MS are still unkown. To fill the gap, we conducted a comprehensive profiling of 44 mature EBV miRNAs in 30 relapse-remitting MS (RRMS) patients at relapse and 30 matched healthy controls...
March 2, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28252605/-autonomic-dysfunction-in-patients-with-multiple-sclerosis
#14
A R Rakhmatullin, K Z Bakhtiiarova, R V Magzhanov
AIM: To optimize the early diagnosis of the autonomic dysfunction in patients with MS. MATERIAL AND METHODS: The main group consisted of 46 patients: 15 men and 31 women with MS (McDonald, 2005), the average age was 33.35±9.9 years, the average score of the Expanded disability scale (EDSS) was 2.8±1.17 points. The control group consisted of 24 healthy subjects matched by age and sex with the main group. A study of the autonomic nervous system was carried out using the Scheme for detection of signs of autonomic disorders (A...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28245725/brain-structural-changes-in-patients-in-the-early-stages-of-multiple-sclerosis-with-depression
#15
J I Rojas, F Sanchez, L Patrucco, J Miguez, C Besada, E Cristiano
Some studies suggest an inflammatory mechanism associated with the presence of depression in multiple sclerosis (MS); however, there is little data concerning these findings. The purpose of this study was to investigate the presence of brain structural changes in patients with MS and depression and to compare them with patients suffering from MS without depression and healthy controls. METHODS: A case-control study that included patients with relapsing-remitting MS (RRMS) defined by validated criteria, over 18 years of age, with less than three years from disease onset, EDSS ≤ 3, with no history of previous depression and under immunomodulatory treatment with interferon beta, if any...
March 1, 2017: Neurological Research
https://www.readbyqxmd.com/read/28241935/remotely-engaged-lessons-from-remote-monitoring-in-multiple-sclerosis
#16
Matthew M Engelhard, Stephen D Patek, Kristina Sheridan, John C Lach, Myla D Goldman
OBJECTIVES: Evaluate web-based patient-reported outcome (wbPRO) collection in MS subjects in terms of feasibility, reliability, adherence, and subject-perceived benefits; and quantify the impact of MS-related symptoms on perceived well-being. METHODS: Thirty-one subjects with MS completed wbPROs targeting MS-related symptoms over six months using a customized web portal. Demographics and clinical outcomes were collected in person at baseline and six months. RESULTS: Approximately 87% of subjects completed wbPROs without assistance, and wbPROs strongly correlated with standard PROs (r>0...
April 2017: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/28241776/the-effectiveness-of-robot-assisted-gait-training-versus-conventional-therapy-on-mobility-in-severely-disabled-progressive-multiple-sclerosis-patients-ragtime-study-protocol-for-a-randomized-controlled-trial
#17
Sofia Straudi, Fabio Manfredini, Nicola Lamberti, Paolo Zamboni, Francesco Bernardi, Giovanna Marchetti, Paolo Pinton, Massimo Bonora, Paola Secchiero, Veronica Tisato, Stefano Volpato, Nino Basaglia
BACKGROUND: Gait and mobility impairments affect the quality of life (QoL) of patients with progressive multiple sclerosis (MS). Robot-assisted gait training (RAGT) is an effective rehabilitative treatment but evidence of its superiority compared to other options is lacking. Furthermore, the response to rehabilitation is multidimensional, person-specific and possibly involves functional reorganization processes. The aims of this study are: (1) to test the effectiveness on gait speed, mobility, balance, fatigue and QoL of RAGT compared to conventional therapy (CT) in progressive MS and (2) to explore changes of clinical and circulating biomarkers of neural plasticity...
February 27, 2017: Trials
https://www.readbyqxmd.com/read/28241268/long-term-outcomes-after-autologous-hematopoietic-stem-cell-transplantation-for-multiple-sclerosis
#18
Paolo A Muraro, Marcelo Pasquini, Harold L Atkins, James D Bowen, Dominique Farge, Athanasios Fassas, Mark S Freedman, George E Georges, Francesca Gualandi, Nelson Hamerschlak, Eva Havrdova, Vassilios K Kimiskidis, Tomas Kozak, Giovanni L Mancardi, Luca Massacesi, Daniela A Moraes, Richard A Nash, Steven Pavletic, Jian Ouyang, Montserrat Rovira, Albert Saiz, Belinda Simoes, Marek Trnený, Lin Zhu, Manuela Badoglio, Xiaobo Zhong, Maria Pia Sormani, Riccardo Saccardi
Importance: Autologous hematopoietic stem cell transplantation (AHSCT) may be effective in aggressive forms of multiple sclerosis (MS) that fail to respond to standard therapies. Objective: To evaluate the long-term outcomes in patients who underwent AHSCT for the treatment of MS in a large multicenter cohort. Design, Setting, and Participants: Data were obtained in a multicenter, observational, retrospective cohort study. Eligibility criteria were receipt of AHSCT for the treatment of MS between January 1995 and December 2006 and the availability of a prespecified minimum data set comprising the disease subtype at baseline; the Expanded Disability Status Scale (EDSS) score at baseline; information on the administered conditioning regimen and graft manipulation; and at least 1 follow-up visit or report after transplant...
February 20, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28239937/smoking-does-not-influence-disability-accumulation-in-primary-progressive-multiple-sclerosis
#19
O Javizian, L M Metz, S Deighton, M W Koch
BACKGROUND AND PURPOSE: The modifiable risk factor cigarette smoking has been associated with an increased risk of developing multiple sclerosis (MS) and with disease activity in relapsing-remitting MS. However, less is known about the effect of smoking on disease progression in progressive MS. Here the association between cigarette smoking and disability accumulation in primary progressive MS (PPMS) is investigated. METHODS: Kaplan-Meier survival analyses and Cox proportional hazard modelling were used to investigate the influence of cigarette smoking on the risk of reaching Expanded Disability Status Scale (EDSS) 4 and 6 as well as the time from EDSS 4 to 6 in patients with PPMS...
April 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28239524/pattern-of-gray-matter-volumes-related-to-retinal-thickness-and-its-association-with-cognitive-function-in-relapsing-remitting-ms
#20
Jan-Patrick Stellmann, Hanife Cetin, Kim Lea Young, Sibylle Hodecker, Jana Pöttgen, Diana Bittersohl, Andrea Hassenstein, Timm Oberwahrenbrock, Christoph Heesen, Susanne Siemonsen
BACKGROUND: Neurodegeneration in multiple sclerosis (MS) may be investigated in the visual system as optical coherence tomography (OCT) and magnetic resonance imaging (MRI) allows examining structural integrity in detail. The association between thickness of retinal layers and focal cortical volumes beyond the primary visual system has not been thoroughly investigated. OBJECTIVE: To investigate the association between focal cortical volume and thickness of retinal layers...
February 2017: Brain and Behavior
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