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https://www.readbyqxmd.com/read/28654790/effect-of-phosphate-amendment-on-relative-bioavailability-and-bioaccessibility-of-lead-and-arsenic-in-contaminated-soils
#1
Shi-Wei Li, Xue Liu, Hong-Jie Sun, Meng-Ya Li, Di Zhao, Jun Luo, Hong-Bo Li, Lena Q Ma
Hand-to-mouth activity is an important pathway for children's exposure to contaminated soils, which is often co-contaminated by Pb and As in mining and smelting sites. To reduce soil Pb risk to humans by oral exposure, phosphate amendments have been used to reduce Pb relative bioavailability (RBA), but its efficiency has not been investigated using validated in vitro assays nor its influence on As-RBA. Here, 5 contaminated soils (A-E) were amended with 0.5% phosphoric acid (PA) to study its effect on Pb- and As- RBA using a newly-developed mouse kidney model and bioaccessibility using 4 in vitro assays including UBM, SBRC, IVG, and PBET...
June 21, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28654673/double-hit-of-nemo-gene-in-preeclampsia
#2
Agata Sakowicz, Tadeusz Pietrucha, Magda Rybak-Krzyszkowska, Hubert Huras, Agnieszka Gach, Bartosz Sakowicz, Mateusz Banaszczyk, Mariusz Grzesiak, Lidia Biesiada
The precise etiology of preeclampsia is unknown. Family studies indicate that both genetic and environmental factors influence its development. One of these factors is NFkB, whose activation depends on NEMO (NFkB essential modulator. This is the first study to investigate the association between the existence of single nucleotide variant of the NEMO gene and the appearance of preeclampsia. A total of 151 women (72 preeclamptic women and 79 controls) and their children were examined. Sanger sequencing was performed to identify variants in the NEMO gene in the preeclamptic mothers...
2017: PloS One
https://www.readbyqxmd.com/read/28654550/promoters-and-barriers-to-implementation-of-tracheal-intubation-airway-safety-bundle-a-mixed-method-analysis
#3
Katherine Finn Davis, Natalie Napolitano, Simon Li, Hayley Buffman, Kyle Rehder, Matthew Pinto, Sholeen Nett, J Dean Jarvis, Pradip Kamat, Ronald C Sanders, David A Turner, Janice E Sullivan, Kris Bysani, Anthony Lee, Margaret Parker, Michelle Adu-Darko, John Giuliano, Katherine Biagas, Vinay Nadkarni, Akira Nishisaki
OBJECTIVES: To describe promoters and barriers to implementation of an airway safety quality improvement bundle from the perspective of interdisciplinary frontline clinicians and ICU quality improvement leaders. DESIGN: Mixed methods. SETTING: Thirteen PICUs of the National Emergency Airway Registry for Children network. INTERVENTION: Remote or on-site focus groups with interdisciplinary ICU staff. Two semistructured interviews with ICU quality improvement leaders with quantitative and qualitative data-based feedbacks...
June 24, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28654500/commentary-on-physical-exercise-and-physical-activity-for-children-and-adolescents-with-juvenile-idiopathic-arthritis-a-literature-review
#4
Patrick van der Torre, Marco van Brussel
No abstract text is available yet for this article.
July 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28654499/physical-exercise-and-physical-activity-for-children-and-adolescents-with-juvenile-idiopathic-arthritis-a-literature-review
#5
Hilenia Catania, Viola Fortini, Rolando Cimaz
PURPOSE: This is a review of studies that investigate the efficacy of exercise therapy and physical activity for children with juvenile idiopathic arthritis since the 2008 Cochrane Review. METHOD: Studies were identified that investigated the use of physical activity and exercise therapy in the treatment of children and adolescents with juvenile idiopathic arthritis, excluding the Cochrane Review. Two reviewers individually analyzed the results of the search to determine the eligibility of studies...
July 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28654475/virtual-reality-and-serious-games-in-neurorehabilitation-of-children-and-adults-prevention-plasticity-and-participation
#6
Judith E Deutsch, Sarah Westcott McCoy
Use of virtual reality (VR) and serious games (SGs) interventions within rehabilitation as motivating tools for task specific training for individuals with neurological conditions are fast-developing. Within this perspective paper we use the framework of the IV STEP conference to summarize the literature on VR and SG for children and adults by three topics: Prevention; Outcomes: Body-Function-Structure, Activity and Participation; and Plasticity. Overall the literature in this area offers support for use of VR and SGs to improve body functions and to some extent activity domain outcomes...
July 2017: Pediatric Physical Therapy
https://www.readbyqxmd.com/read/28654437/self-reported-physical-activity-level-in-student-athletes-at-preparticipation-physical-evaluations
#7
Amy E Valasek, Madison Bieganski, Jana Desrochers, Julie Young
OBJECTIVE: Quantify physical activity in healthy student athletes. DESIGN: Cross-sectional survey. SETTING: Five Central Ohio schools during mass preparticipation physicals. PARTICIPANTS: Three hundred sixty-five children between the ages 10 and 18 years. INDEPENDENT VARIABLES: Days per week of moderate to vigorous physical activity (MVPA), minutes per day of MVPA, and number of activities. MAIN OUTCOME MEASURES: Minutes per week of MVPA...
June 22, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28653967/exercise-associated-hyponatremia-in-a-lactating-female
#8
Zach Bailowitz, Raymond Grams, David Teeple, Tamara Hew-Butler
A 37-year-old woman presented to the emergency department with severe headache, which quickly progressed to altered mental status and seizure activity in hospital. Her initial serum sodium concentration ([Na]) was 126 mmol/L. In the 24 hours before admission, she exercised vigorously for 120 minutes (interval training plus yoga) and also consumed more than 4 liters of fluid during that time to both stay hydrated and facilitate milk production because she was actively nursing 2 children. Her serum [Na] and altered mental status corrected slowly over the next 48 hours with furosemide, hypertonic saline, and fluid restriction...
July 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28653785/lung-function-in-relation-to-farm-dwelling-and-farming-activities-in-rural-dwelling-children
#9
Lakshmi Balakrishnan, Donna Rennie, James Dosman, Punam Pahwa, Chandima Karunanayake, Louise Hagel, Joshua Lawson
BACKGROUND AND OBJECTIVE: The relationship between farming exposures and pulmonary function in a rural paediatric population was evaluated. METHODS: Baseline data collection records of the Saskatchewan Rural Health Study (SRHS), a population-based study, were used. A subset of children (6-14 years old) participated in clinical testing, including anthropometric measures and pulmonary function testing (PFT), using spirometry (n = 584). PFTs followed ATS criteria and all statistical analyses were controlled for age, sex and height...
June 27, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28653767/if-you-re-happy-and-you-know-it-positive-moods-reduce-age-related-differences-in-false-memory
#10
Weiwei Zhang, Julien Gross, Harlene Hayne
When tested in the Deese-Roediger-McDermott paradigm, children typically exhibit fewer false memories than do adolescents or adults. Here, participants' moods and the valence of word lists were manipulated to explore the mechanism responsible for this developmental reversal in memory performance. Children (7- to 8-year-olds), adolescents (11- to 12-year-olds), and young adults (18- to 22-year-olds; N = 270) were assigned to one of three induced mood conditions and were presented with emotional word lists...
June 27, 2017: Child Development
https://www.readbyqxmd.com/read/28652913/evaluation-of-immunization-coverage-and-its-associated-factors-among-children-12-23-months-of-age-in-techiman-municipality-ghana-2016
#11
Martin Nyaaba Adokiya, Benjamin Baguune, Joyce Aputere Ndago
BACKGROUND: In Ghana, Expanded Programme on Immunization administrative coverages are usually high while childhood immunization status remains low. Majority of children do not receive all the recommended 7 vaccines in 15 doses before 1 year of age. Surveys to validate administrative coverages and identify predictors of immunization status are not given the desired attention. Thus, the objective of this study was to evaluate the immunization coverage and its associated factors among children aged 12-23 months in Techiman Municipality, Ghana...
2017: Archives of Public Health, Archives Belges de Santé Publique
https://www.readbyqxmd.com/read/28652828/prevention-treatment-and-rehabilitation-of-anterior-cruciate-ligament-injuries-in-children
#12
REVIEW
Pamela J Lang, Dai Sugimoto, Lyle J Micheli
As more children and adolescents participate in competitive organized sports, there has been an increase in the reported incidence of anterior cruciate ligament (ACL) injuries in these age groups. ACL injuries in skeletally immature athletes present a challenge, as reconstruction must preserve the physis of the distal femur and of the proximal tibia to avoid growth disturbances. Historically, a skeletally immature athlete with an ACL injury was treated with a brace and activity modification until skeletal maturity, with ACL reconstruction being performed at that time in the "non-copers" who experienced instability...
2017: Open Access Journal of Sports Medicine
https://www.readbyqxmd.com/read/28652534/poly-u-and-cpg-ameliorate-the-unbalanced-t-cell-immunity-and-pneumonia-of-mice-with-rsv-vaccine-enhanced-disease
#13
Ran Jia, Lu Lu, Xiaozhen Liang, Zhiwu Sun, Lingbing Tan, Menghua Xu, Liyun Su, Jin Xu
Respiratory Syncycial Virus (RSV) is the most important pathogen responsible for children's severe lower respiratory tract infection. So far no RSV vaccine has yet been authorized for clinical use. The main impediment that blocked development of RSV vaccine is that inactivated RSV vaccine could cause RSV vaccine-enhanced disease (RVED). The mechanism of RVED remains unclear. Recently some researchers found that insufficient activation of innate immunity, including Toll-like receptors (TLRs), might be associated with the onset of RVED...
June 26, 2017: Bioscience Trends
https://www.readbyqxmd.com/read/28652525/sugar-sweetened-beverages-consumption-positively-associated-with-the-risks-of-obesity-and-hypertriglyceridemia-among-children-aged-7-18-years-in-south-china
#14
Baoting He, Weiqing Long, Xiuhong Li, Wenhan Yang, Yajun Chen, Yanna Zhu
AIMS: Excessive consumption of sugar-sweetened beverages (SSBs) may increase the prevalence of obesity and other metabolic risk factors. However, data regarding the relationship between SSB consumption and metabolic risk factors are insufficient in Chinese children. Hence, we aimed to explore the association between SSB consumption and cardio-metabolic risk factors in children aged 7-18 years living in South China. METHODS: A cross-sectional study was conducted in a total of 2,032 children aged 7-18 years were enrolled, including 1,013 boys and 1,019 girls...
June 23, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28652242/preclinical-characterization-of-the-inhaled-small-molecule-respiratory-syncytial-virus-l-protein-polymerase-inhibitor-pc786
#15
Matthew Coates, Daniel Brookes, Young-In Kim, Heather Allen, Euan A F Fordyce, Elizabeth A Meals, Thomas Colley, Claire-Lise Ciana, Guillaume F Parra, Vladimir Sherbukhin, Jennifer A Stockwell, Jennifer C Thomas, S Fraser Hunt, Lauren Anderson-Dring, Stuart T Onions, Lindsey Cass, Peter J Murray, Kazuhiro Ito, Pete Strong, John P Devincenzo, Garth Rapeport
Although respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infection in infants and young children, attempts to develop an effective therapy have so far proved unsuccessful. Herein we report the preclinical profiles of PC786, a potent non-nucleoside RSV L-protein polymerase inhibitor, designed for inhalation treatment of RSV infection. PC786 demonstrated a potent and selective anti-viral activity against laboratory adapted or clinical isolates of RSVA (IC50: <0.09 - 0...
June 26, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28652148/value-of-upper-endoscopic-biopsies-in-predicting-medical-refractoriness-in-pediatric-patients-with-ulcerative-colitis
#16
Katrina J Sullivan, Mike Wei, Elizabeth Chernetsova, Soufiane Hallani, Joseph de Nanassy, Eric I Benchimold, David R Mack, Ahmed Nasr, Dina El Demellawy
Refractory ulcerative colitis (UC) occurs in patients who experience a severe disease manifestation that is unresponsive to medical therapy. The assessment of upper endoscopic microscopic findings and its correlation with refractory UC has not been fully studied in pediatric patients, and is the focus of this study. Medical records of UC patients treated at a tertiary pediatric center between 2000 and 2014 were reviewed. Endoscopic biopsies of the upper gastrointestinal tract of patients meeting a priori inclusion criteria were compared between refractory UC patients and non-refractory UC patients for active inflammation...
June 23, 2017: Human Pathology
https://www.readbyqxmd.com/read/28652085/the-influence-of-fathers-on-children-s-physical-activity-a-review-of-the-literature-from-2009-to-2015
#17
REVIEW
Cody D Neshteruk, Brooke T Nezami, Gianna Nino-Tapias, Kirsten K Davison, Dianne S Ward
Parents are influential in promoting children's physical activity. Yet, most research has focused on how mothers influence children's activity, while little empirical attention has been devoted to understanding how fathers may influence children's activity. The purpose of this review was to summarize observational studies from 2009 to 2015 examining the influence of fathers on children's physical activity. A publicly available database, from a prior systematic review, containing information on 667 studies of parenting and childhood obesity from 2009 to 2015 was searched for potential studies...
June 23, 2017: Preventive Medicine
https://www.readbyqxmd.com/read/28651838/progress-and-challenges-in-measles-and-rubella-elimination-in-the-who-european-region
#18
Siddhartha Sankar Datta, Patrick Michael O'Connor, Dragan Jankovic, Mark Muscat, Myriam Corrine Ben Mamou, Simarjit Singh, Theodoros Kaloumenos, Susan Reef, Mark Papania, Robb Butler
INTRODUCTION: Despite availability of safe and cost-effective vaccines to prevent it, measles remains one of the significant causes of death among children under five years of age globally. The World Health Organization (WHO) European Region has seen a drastic decline in measles and rubella cases in recent years, and a few of the once common measles genotypes are no longer detected. Buoyed by this success, all Member States of the Region reconfirmed their commitment in 2010 to eliminating measles and rubella, and made this a central objective of the European Vaccine Action Plan 2015-2020 (EVAP)...
June 23, 2017: Vaccine
https://www.readbyqxmd.com/read/28651798/cycling-to-school-and-body-composition-physical-fitness-and-metabolic-syndrome-in-children-and-adolescents
#19
Robinson Ramírez-Vélez, Antonio García-Hermoso, Cesar Agostinis-Sobrinho, Jorge Mota, Rute Santos, Jorge Enrique Correa-Bautista, Deisy Constanza Amaya-Tambo, Emilio Villa-González
OBJECTIVE: To evaluate the association between cycling to/from school and body composition, physical fitness, and metabolic syndrome among a sample of Colombian children and adolescents. STUDY DESIGN: During the 2014-2015 school year, we examined a cross-sectional component of the Association for muscular strength with early manifestation of cardiovascular disease risk factors among Colombian children and adolescents (FUPRECOL) study. Participants included 2877 youths (54...
June 23, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28651593/maternal-antibodies-protect-offspring-from-severe-influenza-infection-and-do-not-lead-to-detectable-interference-with-subsequent-offspring-immunization
#20
Joan E M van der Lubbe, Jessica Vreugdenhil, Sarra Damman, Joost Vaneman, Jaco Klap, Jaap Goudsmit, Katarina Radošević, Ramon Roozendaal
BACKGROUND: Various studies have shown that infants under the age of 6 months are especially vulnerable for complications due to influenza. Currently there are no vaccines licensed for use in this age group. Vaccination of pregnant women during the last trimester, recommended by the WHO as protective measure for this vulnerable female population, may provide protection of newborns at this early age. Although it has been observed that maternal vaccination can passively transfer protection, maternal antibodies could possibly also interfere with subsequent active vaccination of the offspring...
June 26, 2017: Virology Journal
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