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https://www.readbyqxmd.com/read/28535583/molecular-testing-of-brain-tumor
#1
REVIEW
Sung-Hye Park, Jaekyung Won, Seong-Ik Kim, Yujin Lee, Chul-Kee Park, Seung-Ki Kim, Seung-Hong Choi
The World Health Organization (WHO) classification of central nervous system (CNS) tumors was revised in 2016 with a basis on the integrated diagnosis of molecular genetics. We herein provide the guidelines for using molecular genetic tests in routine pathological practice for an accurate diagnosis and appropriate management. While astrocytomas and IDH-mutant (secondary) glioblastomas are characterized by the mutational status of IDH, TP53 , and ATRX , oligodendrogliomas have a 1p/19q codeletion and mutations in IDH, CIC , FUBP1 , and the promoter region of telomerase reverse transcriptase ( TERTp )...
May 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28534928/music-genetics-research-association-with-musicality-of-a-polymorphism-in-the-avpr1a-gene
#2
Luiza Monteavaro Mariath, Alexandre Mauat da Silva, Thayne Woycinck Kowalski, Gustavo Schulz Gattino, Gustavo Andrade de Araujo, Felipe Grahl Figueiredo, Alice Tagliani-Ribeiro, Tatiana Roman, Fernanda Sales Luiz Vianna, Lavínia Schuler-Faccini, Jaqueline Bohrer Schuch
Musicality is defined as a natural tendency, sensibility, knowledge, or talent to create, perceive, and play music. Musical abilities involve a great range of social and cognitive behaviors, which are influenced by both environmental and genetic factors. Although a number of studies have yielded insights into music genetics research, genes and biological pathways related to these traits are not fully understood. Our hypothesis in the current study is that genes associated with different behaviors could also influence the musical phenotype...
May 22, 2017: Genetics and Molecular Biology
https://www.readbyqxmd.com/read/28534860/hemophilia-care-in-the-pediatric-age
#3
REVIEW
Marta Bertamino, Francesca Riccardi, Laura Banov, Johanna Svahn, Angelo Claudio Molinari
Hemophilia is the most common of the severe bleeding disorders and if not properly managed since early infancy can lead to chronic disease and lifelong disabilities. However, it enjoys the most efficacious and safe treatment among the most prevalent monogenic disorders. Hemophilia should be considered in the neonatal period in the case of unusual bleeding or in the case of positive family history. Later, hemophilia should be suspected mainly in males because of abnormal bruising/bleeding or unusual bleeding following invasive procedures-for example, tonsillectomy or circumcision...
May 19, 2017: Journal of Clinical Medicine
https://www.readbyqxmd.com/read/28534459/differences-in-neural-response-to-extinction-recall-in-young-adults-with-or-without-history-of-behavioral-inhibition
#4
Tomer Shechner, Nathan A Fox, Jamie A Mash, Johanna M Jarcho, Gang Chen, Ellen Leibenluft, Daniel S Pine, Jennifer C Britton
Behavioral inhibition (BI) is a temperament identified in early childhood that is associated with risk for anxiety disorders, yet only about half of behaviorally inhibited children manifest anxiety later in life. We compared brain function and behavior during extinction recall in a sample of nonanxious young adults characterized in childhood with BI (n = 22) or with no BI (n = 28). Three weeks after undergoing fear conditioning and extinction, participants completed a functional magnetic resonance imaging extinction recall task assessing memory and threat differentiation for conditioned stimuli...
May 23, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28534182/imaging-children-suffering-from-lymphoma-an-evaluation-of-different-18-f-fdg-pet-mri-protocols-compared-to-whole-body-dw-mri
#5
Julian Kirchner, Cornelius Deuschl, Bernd Schweiger, Ken Herrmann, Michael Forsting, Christian Buchbender, Gerald Antoch, Lale Umutlu
OBJECTIVES: The objectives of this study were to evaluate and compare the diagnostic potential of different PET/MRI reading protocols, entailing non-enhanced / contrast-enhanced and diffusion-weighted (18)F-FDG PET/MR imaging and whole-body diffusion-weighted MRI for lesion detection and determination of the tumor stage in pediatric lymphoma patients. METHODS: A total of 28 (18)F-FDG PET/MRI datasets were included for analysis of four different reading protocols: (1) PET/MRI utilizing sole unenhanced T2w and T1w imaging, (2) PET/MRI utilizing additional contrast enhanced sequences, (3) PET/MR imaging utilizing unenhanced, contrast enhanced and DW imaging or (4) WB-DW-MRI...
May 22, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28534124/parental-misperception-of-child-s-weight-and-related-factors-within-family-norms
#6
Seo Ah Hong, Karl Peltzer, Chutima Jalayondeja
PURPOSE: Parental perception of their child's weight may be a crucial factor in parental ability for action with regard to their child's weight problem. This aim of this study was to investigate parental perception of their child's weight status and dietary healthiness, amount of food consumed and physical activity level and its related factors. METHODS: A cross-sectional survey was conducted among children (Grades 4-6) selected by cluster sampling in two schools...
May 22, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28533630/effects-of-hippotherapy-on-the-thickness-of-deep-abdominal-muscles-and-activity-of-daily-living-in-children-with-intellectual-disabilities
#7
JiHyun Lee, Chang-Kyo Yun
[Purpose] The purpose of this study is to investigate the effect of hippotherapy exercise on the thickness of deep abdominal muscles and daily activities of children with intellectual disabilities. [Subjects and Methods] Seven children with intellectual disabilities were treated with hippotherapy for 30 minutes twice a week for 6 weeks. The thickness of deep abdominal muscles and Functional Independence Measure (FIM) of the subjects were measured by ultrasonography before and after the experiment. [Results] There was no significant change in the thickness of the External Oblique and Internal Oblique muscles, but there was a statistically significant change in Transverse Adbominis thickness and FIM score after treatment compared to before treatment...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533628/the-effects-of-neck-and-trunk-stabilization-exercises-on-cerebral-palsy-children-s-static-and-dynamic-trunk-balance-case-series
#8
Ji-Won Shin, Gui-Bin Song, Jooyeon Ko
[Purpose] The purpose of this case series was to examination the effects of trunk and neck stabilization exercise on the static, dynamic trunk balance abilities of children with cerebral palsy. [Subjects and Methods] The study included 11 school aged children diagnosed with paraplegia due to a premature birth. Each child engaged in exercise treatments twice per week for eight weeks; each treatment lasted for 45 minutes. After conducting a preliminary assessment, exercise treatments were designed based on each child's level of functioning...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533588/transformative-learning-experience-for-physical-therapy-students-through-a-community-health-promotion-project-for-mothers-of-hearing-challenged-children
#9
Masami Yokogawa, Masako Notoya, Sachiko Madokoro
[Purpose] The purpose of this project was to expose physical therapy students to transformative learning through a community health promotion project for mothers of hearing-challenged children. [Subjects and Methods] The participants were three mothers with their respective hearing-challenged child and twenty physical therapy students. The project consisted of seven sessions supervised throughout by a physical therapy instructor. The students participated in seven sessions, while the mothers were required to attend only two sessions of a health checkup and exercise program...
April 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28533112/where-arithmetic-and-phonology-meet-the-meta-analytic-convergence-of-arithmetic-and-phonological-processing-in-the-brain
#10
Courtney Pollack, Nicole C Ashby
Arithmetic facts can be solved using different strategies. Research suggests that some arithmetic problems, particularly those solved by fact retrieval, are related to phonological processing ability and elicit activity in left-lateralized brain regions that support phonological processing. However, it is unclear whether common brain regions support both retrieval-based arithmetic and phonological processing, and if these regions differ across children and adults. This study used activation likelihood estimation to investigate functional neural overlap between arithmetic and phonological processing, separately for children and adults...
May 10, 2017: Developmental Cognitive Neuroscience
https://www.readbyqxmd.com/read/28532818/tdp-43-upregulation-mediated-by-the-nlrp3-inflammasome-induces-cognitive-impairment-in-2-2-4-4-tetrabromodiphenyl-ether-bde-47-treated-mice
#11
Juan Zhuang, Xin Wen, Yan-Qiu Zhang, Qun Shan, Zi-Feng Zhang, Gui-Hong Zheng, Shao-Hua Fan, Meng-Qiu Li, Dong-Mei Wu, Bin Hu, Jun Lu, Yuan-Lin Zheng
It is now commonly known that exposure to polybrominated diphenyl ethers (PBDEs) may cause neurotoxicity and cognitive deficits in children as well as adults, but the underlying mechanisms are still not clear. In the present study, we aimed to elucidate the potential underlying mechanism of 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47)-induced neurotoxicity and cognitive impairment. Our results showed that BDE-47-treated mice exhibited impaired cognition and robust upregulation of nuclear TDP-43 in the hippocampus...
May 19, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28532658/secondhand-smoke-exposure-and-pediatric-healthcare-visits-and-hospitalizations
#12
Ashley L Merianos, Roman A Jandarov, E Melinda Mahabee-Gittens
INTRODUCTION: This study assessed the relationship between secondhand smoke exposure (SHSe) as measured by serum cotinine and healthcare utilization among children. METHODS: In 2016, the 2009-2012 National Health and Nutrition Examination Survey data were analyzed including 4,985 children aged 3-19 years. Associations between SHSe and having a routine place for healthcare, type of place, and hospital utilization were examined using logistic regression models. Poisson regression analyses assessed the relationship between SHSe and number of hospital admissions...
May 19, 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28532627/regenerative-medicine-in-hearing-recovery
#13
REVIEW
Edi Simoni, Giulia Orsini, Milvia Chicca, Simone Bettini, Valeria Franceschini, Alessandro Martini, Laura Astolfi
Hearing loss, or deafness, affects 360 million people worldwide of which about 32 million are children. Deafness is irreversible when it involves sensory hair cell death because the regenerative ability of these cells is lost in mammals after embryo development. The therapeutic strategies for deafness include hearing aids and/or implantable devices. However, not all patients are eligible or truly benefit from these medical devices. Regenerative medicine based on stem cell application could play a role in both improvement of extant medical devices and in vivo recovery of auditory function by regeneration of inner ear cells and neurons...
May 19, 2017: Cytotherapy
https://www.readbyqxmd.com/read/28532502/perceived-reciprocal-value-of-health-professionals-participation-in-global-child-health-related-work
#14
Sarah Carbone, Jannah Wigle, Nadia Akseer, Raluca Barac, Melanie Barwick, Stanley Zlotkin
BACKGROUND: Leading children's hospitals in high-income settings have become heavily engaged in international child health research and educational activities. These programs aim to provide benefit to the institutions, children and families in the overseas locations where they are implemented. Few studies have measured the actual reciprocal value of this work for the home institutions and for individual staff who participate in these overseas activities. Our objective was to estimate the perceived reciprocal value of health professionals' participation in global child health-related work...
May 22, 2017: Globalization and Health
https://www.readbyqxmd.com/read/28532331/is-restlessness-best-understood-as-a-process-reflecting-on-four-boys-restlessness-during-music-therapy-in-kindergarten
#15
Anna Helle-Valle, Per-Einar Binder, Norman Anderssen, Brynjulf Stige
ADHD can be considered an internationally recognized framework for understanding children's restlessness. In this context, children's restlessness is understood as a symptom of neurodevelopmental disorder. However, there are other possible understandings of children's restlessness. In this article, we explore four boys' collaborative and creative process as it is described and understood by three adults. The process is framed by a community music therapy project in a Norwegian kindergarten, and we describe four interrelated phases of this process: Exploring musical vitality and cooperation, Consolidating positions, Performing together, and Discovering ripple effects...
June 2017: International Journal of Qualitative Studies on Health and Well-being
https://www.readbyqxmd.com/read/28532318/potential-moderators-of-day-to-day-variability-in-children-s-physical-activity-patterns
#16
Nicola D Ridgers, Lisa M Barnett, David R Lubans, Anna Timperio, Ester Cerin, Jo Salmon
Little is known about whether physical activity compensation occurs and, if so, what are potential moderators of such responses. This study examined whether children's physical activity, sedentary time and energy expenditure on one day was associated with these behaviours the following day, and what factors may moderate observed associations. One hundred and twenty-seven children (8-11 years) wore an ActiGraph accelerometer for eight days. Time spent in sedentary time and physical activity was obtained. Daily energy expenditure was also assessed using a SenseWear Armband (n=98)...
May 22, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/28532208/the-burden-of-and-risk-factors-for-trachoma-in-selected-districts-of-zimbabwe-results-of-16-population-based-prevalence-surveys
#17
Isaac Phiri, Portia Manangazira, Colin K Macleod, Takafira Mduluza, Tinashe Dhobbie, Shorai Grace Chaora, Chriswell Chigwena, Joshua Katiyo, Rebecca Willis, Ana Bakhtiari, Peter Bare, Paul Courtright, Boniface Macheka, Nicholas Midzi, Anthony W Solomon
BACKGROUND: Trachoma, a leading cause of blindness, is targeted for global elimination as a public health problem by 2020. In order to contribute to this goal, countries should demonstrate reduction of disease prevalence below specified thresholds, after implementation of the SAFE strategy in areas with defined endemicity. Zimbabwe had not yet generated data on trachoma endemicity and no specific interventions against trachoma have yet been implemented. METHODS: Two trachoma mapping phases were successively implemented in Zimbabwe, with eight districts included in each phase, in September 2014 and October 2015...
May 22, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28532185/tone-perception-in-mandarin-speaking-children-with-cochlear-implants
#18
Gang Li, Sigfrid D Soli, Yun Zheng
OBJECTIVE: To evaluate the effects of implant age and duration of implantation on development of Mandarin tone perception in paediatric cochlear implant recipients. DESIGN: Retrospective cross-sectional evaluation of tone perception, as assessed with the Mandarin Early Speech Perception test at 3, 6, 12, 24, 36 and 48 months after activation. STUDY SAMPLE: A total of 143 subjects, 60 girls and 83 boys unilaterally implanted at 1-4 years of age comprised the sample...
May 22, 2017: International Journal of Audiology
https://www.readbyqxmd.com/read/28531881/first-in-man-dose-escalation-and-pharmacokinetic-study-of-cap7-1-a-novel-prodrug-of-etoposide-in-adults-with-refractory-solid-tumours
#19
U Keilholz, L Rohde, P Mehlitz, M Knoedler, A Schmittel, V Kümmerlen, K Klinghammer, P Treasure, M Lassus, G Steventon, M Machacek, N Utku
AIM: An open-label, phase I dose-escalation trial was performed in adult patients with various solid cancers to identify the maximum tolerated dose (MTD), to assess the safety, pharmacokinetic profile and anti-tumour activity of the new prodrug CAP7.1. The prodrug is converted to its active moiety etoposide via carboxylesterases in selective cells leading to a better tolerability and higher efficacy in therapeutic resistance cells and children with refractory neuroblastoma. PATIENTS AND METHODS: Eligible adult patients with advanced, refractory, solid malignancies received CAP7...
May 19, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28531622/implementation-of-a-municipality-based-intervention-program-aiming-to-improve-dietary-and-physical-activity-habits-of-school-aged-children-and-their-families-results-of-the-paideiatrofi-program
#20
Helena Stamou, Konstantina Voulgari, Eftychia Apostolidou, Vladlena Khudokonenko, George Moschonis, Yannis Manios
No abstract text is available yet for this article.
June 2016: Clinical Nutrition ESPEN
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