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https://www.readbyqxmd.com/read/28217700/the-multiple-antibacterial-activities-of-the-bladder-epithelium
#1
REVIEW
Jianxuan Wu, Yuxuan Miao, Soman N Abraham
The urinary tract is subject to frequent challenges from the gut microflora. Indeed, up to 40% of women will experience at least one urinary tract infection (UTI) during their lifetime. Uropathogenic Escherichia coli (UPEC) contribute to an overwhelming majority of these cases and they typically initiate UTIs by invading the superficial epithelium that lines the bladder lumen. In addition to serving as an effective barrier to noxious agents found in urine, bladder epithelial cells (BECs) play a key physiological role in regulating bladder volume to accommodate urine flow...
January 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/28216570/an-electromagnetic-sensor-for-the-autonomous-running-of-visually-impaired-and-blind-athletes-part-i-the-fixed-infrastructure
#2
Marco Pieralisi, Valentina Di Mattia, Valerio Petrini, Alfredo De Leo, Giovanni Manfredi, Paola Russo, Lorenzo Scalise, Graziano Cerri
Sport is one of the best ways to promote the social integration of people affected by physical disability, because it helps them to increase their self-esteem by facing difficulties and overcoming their disabilities. Nowadays, a large number of sports can be easily played by visually impaired and blind athletes without any special supports, but, there are some disciplines that require the presence of a sighted guide. In this work, the attention will be focused on marathons, during which athletes with visual disorders have to be linked to the sighted guide by means of a non-stretchable elbow tether, with an evident reduction of their performance and autonomy...
February 14, 2017: Sensors
https://www.readbyqxmd.com/read/28184188/stimulus-phase-locking-of-cortical-oscillations-for-rhythmic-tone-sequences-in-rats
#3
Takahiro Noda, Tomoki Amemiya, Tomoyo I Shiramatsu, Hirokazu Takahashi
Humans can rapidly detect regular patterns (i.e., within few cycles) without any special attention to the acoustic environment. This suggests that human sensory systems are equipped with a powerful mechanism for automatically predicting forthcoming stimuli to detect regularity. It has recently been hypothesized that the neural basis of sensory predictions exists for not only what happens (predictive coding) but also when a particular stimulus occurs (predictive timing). Here, we hypothesize that the phases of neural oscillations are critical in predictive timing, and these oscillations are modulated in a band-specific manner when acoustic patterns become predictable, i...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28183332/mothers-views-about-sexual-health-education-for-their-adolescent-daughters-a-qualitative-study
#4
Mohsen Shams, Sa'adat Parhizkar, Ali Mousavizadeh, Masoumeh Majdpour
BACKGROUND: Given that mothers play a role in the sexual education of their daughters, it is important to understand their views of sexual health and related programs. This study was aimed at exploring mothers' perspectives regarding sexual health education for their adolescent daughters in Mahshahr, Iran. METHODS: In this qualitative study, in-depth interviews with ten key informants and five focus group discussions involving 28 mothers with daughters aged 12-18 were conducted...
February 10, 2017: Reproductive Health
https://www.readbyqxmd.com/read/28157157/an-overview-of-multimodal-neuroimaging-using-nanoprobes
#5
REVIEW
Sriram Sridhar, Sachin Mishra, Miklós Gulyás, Parasuraman Padmanabhan, Balázs Gulyás
Nanomaterials have gained tremendous significance as contrast agents for both anatomical and functional preclinical bio-imaging. Contrary to conventional medical practices, molecular imaging plays an important role in exploring the affected cells, thus providing precision medical solutions. It has been observed that incorporating nanoprobes improves the overall efficacy of the diagnosis and treatment processes. These nano-agents and tracers are therefore often incorporated into preclinical therapeutic and diagnostic applications...
February 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28153277/paper-based-capacitive-sensors-for-identification-and-quantification-of-chemicals-at-the-point-of-care
#6
Jie Hu, Chee-Hong Takahiro Yew, Xiaoshuang Chen, Shangsheng Feng, Qu Yang, Shuqi Wang, Wei-Hong Wee, Belinda Pingguan-Murphy, Tian Jian Lu, Feng Xu
The identification and quantification of chemicals play a vital role in evaluation and surveillance of environmental health and safety. However, current techniques usually depend on costly equipment, professional staff, and/or essential infrastructure, limiting their accessibility. In this work, we develop paper-based capacitive sensors (PCSs) that allow simple, rapid identification and quantification of various chemicals from microliter size samples with the aid of a handheld multimeter. PCSs are low-cost parallel-plate capacitors (~$0...
April 1, 2017: Talanta
https://www.readbyqxmd.com/read/28151702/the-athletic-shoe-in-football
#7
James Jastifer, Richard Kent, Jeff Crandall, Chris Sherwood, David Lessley, Kirk A McCullough, Michael J Coughlin, Robert B Anderson
BACKGROUND: Foot and ankle injuries are common in sports, particularly in cleated athletes. Traditionally, the athletic shoe has not been regarded as a piece of protective equipment but rather as a part of the uniform, with a primary focus on performance and subjective feedback measures of comfort. Changes in turf and shoe design have poorly understood implications on the health and safety of players. EVIDENCE ACQUISITION: A literature search of the MEDLINE and PubMed databases was conducted...
March 2017: Sports Health
https://www.readbyqxmd.com/read/28149455/the-influence-of-length-of-implant-on-primary-stability-an-in-vitro-study-using-resonance-frequency-analysis
#8
Anwar B Bataineh, Ala M Al-Dakes
BACKGROUND: Primary stabilityis not sufficientin less contact area between the implant and bone, the healing process because will be disrupted due to micro-motions and fibrous tissue affects osseointegration. MATERIAL AND METHODS: We implemented an in vitro experimental study of total 135 XiVE® implants were inserted in 22.5 bovine cow ribs with bone quality similar to a type IV human bone. Each rib end received a group of three different implant lengths, which were 8mm, 13mm and 15mm and had the same diameter 3...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28142135/frequency-and-genotype-of-human-parvovirus-b19-among-iranian-hemodialysis-and-peritoneal-dialysis-patients
#9
Alireza Sharif, Arezoo Aghakhani, Ali Akbar Velayati, Mohammad Banifazl, Mohammad Reza Sharif, Effat Razeghi, Davood Kheirkhah, Monireh Kazemimanesh, Anahita Bavand, Amitis Ramezani
OBJECTIVES: The aim of this study was to evaluate the frequency and genotype of human parvovirus B19 and its relation with anemia among Iranian patients under dialysis. METHODS: Fifty hemodialysis (HD) and 33 peritoneal dialysis (PD) patients were enrolled. B19 IgG and IgM antibodies were assessed by ELISA, and the presence of B19 DNA was evaluated by nested PCR. PCR products were sequenced directly and phylogenetic analysis was performed. RESULTS: In the HD group, the prevalence of B19 antibodies was 54% for IgG and 4% for IgM...
2016: Intervirology
https://www.readbyqxmd.com/read/28139158/usability-and-utility-evaluation-of-the-web-based-should-i-start-insulin-patient-decision-aid-for-patients-with-type-2-diabetes-among-older-people
#10
Yew Kong Lee, Ping Yein Lee, Chirk Jenn Ng, Chin Hai Teo, Ahmad Ihsan Abu Bakar, Khatijah Lim Abdullah, Ee Ming Khoo, Nik Sherina Hanafi, Wah Yun Low, Thiam Kian Chiew
This study aimed to evaluate the usability (ease of use) and utility (impact on user's decision-making process) of a web-based patient decision aid (PDA) among older-age users. A pragmatic, qualitative research design was used. We recruited patients with type 2 diabetes who were at the point of making a decision about starting insulin from a tertiary teaching hospital in Malaysia in 2014. Computer screen recording software was used to record the website browsing session and in-depth interviews were conducted while playing back the website recording...
January 31, 2017: Informatics for Health & Social Care
https://www.readbyqxmd.com/read/28131859/systems-biology-of-robustness-and-flexibility-lactobacillus-buchneri-a-show-case
#11
REVIEW
Stefan Heinl, Reingard Grabherr
Lactobacillus buchneri is a lactic acid bacterium that naturally inhabits very different ecological niches and plays an ambivalent role in many food and feed fermentation processes, where it can act as useful starter or as spoilage organism. Due to its vicinity to important biotechnological processes like silage making, ethanol production, baking, fermenting vegetables or brewing, L. buchneri was subject of extensive research and is now a quite well studied microorganism. Recently, next generation 'OMICS'-methods were applied to investigate L...
January 25, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/28127574/determination-of-cellular-phosphatidylinositol-3-phosphate-pi3p-levels-using-a-fluorescently-labelled-selective-pi3p-binding-domain-px
#12
Michael J Munson, Ian G Ganley
The lipid Phosphatidylinositol-3-phosphate [PtdIns3P or PI(3)P] plays many membrane trafficking roles and is primarily produced by the Class III PI3K, VPS34. Determining the level of cellular PI(3)P however can be complex. Extraction of cellular lipids by methanol/chloroform can struggle to separate and identify distinct phospholipid species. Alternately mass spectrometry may be utilised but this requires significant set up of specialised equipment and time to utilise. Use of a PI(3)P-binding-specific recombinant protein domain is a quick method for ascertaining cellular PI(3)P levels and can also allow visualisation of sub-cellular localisation...
August 20, 2016: Bio-protocol
https://www.readbyqxmd.com/read/28124019/dynamics-of-self-directed-learning-in-m-sc-nursing-students-a-qualitative-research
#13
Fatemeh Shirazi, Farkhondeh Sharif, Zahra Molazem, Mahboobeh Alborzi
INTRODUCTION: Working in the complex and ever changing healthcare settings forces the nurses and nursing students to be equipped with lifelong learning skills. One of the lifelong learning skills is self-directed learning. This study aimed to explore the M.Sc. nursing students' self-directed learning activities. METHODS: A qualitative design using conventional content analysis approach was used in this study. Semi-structured interviews were conducted with twelve Iranian M...
January 2017: Journal of Advances in Medical Education & Professionalism
https://www.readbyqxmd.com/read/28122492/self-treatment-of-acute-exacerbations-of-chronic-obstructive-pulmonary-disease-requires-more-than-symptom-recognition-a-qualitative-study-of-copd-patients-perspectives-on-self-treatment
#14
Johanna Laue, Hasse Melbye, Mette Bech Risør
BACKGROUND: Self-treatment of acute exacerbations of COPD with antibiotics and/or oral corticosteroids has emerged as a promising strategy to reduce hospitalization rates, mortality and health costs. However, for reasons little understood, the effect of self-treatment, particularly when not part of comprehensive self-management programs, remains unclear. Therefore, this study aims to get insight into the patients' perspective on self-treatment of acute exacerbations of COPD, focusing specifically on how patients decide for the right moment to start treatment with antibiotics and/or oral corticosteroids, what they consider important when making this decision and aspects which might interfere with successful implementation...
January 25, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28121079/a-novel-cosmetic-antifungal-anti-inflammatory-topical-gel-for-the-treatment-of-mild-to-moderate-seborrheic-dermatitis-of-the-face-a-open-label-trial-utilizing-clinical-evaluation-and-erythemadirected-digital-photography
#15
Federica Dall'oglio, Aurora Tedeschi, Carmelinda M Fusto, Francesco Lacarrubba, Franco Dinotta, Giuseppe Micali
BAKGROUND: Topical cosmetic agents may play a role in the management of facial seborrheic dermatitis by reducing inflammation and scale production. Advanced digital photography, equipped with technology able to provide a detailed evaluation of red skin components corresponding to vascular flare (erythema-directed digital photography), is a useful tool for evaluation of erythema in patients affected by inflammatory dermatoses. The aim of this study was to assess the efficacy and safety of a new cosmetic topical gel containing ciclopiroxolamine, lactoferrin, glycero-phosphoinositol (GPI) and Aloe vera, for the treatment of facial seborrheic dermatitis by clinical and advanced digital photography evaluation...
January 24, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28107834/a-label-free-colorimetric-isothermal-cascade-amplification-for-the-detection-of-disease-related-nucleic-acids-based-on-double-hairpin-molecular-beacon
#16
Dong Wu, Huo Xu, Haimei Shi, Weihong Li, Mengze Sun, Zai-Sheng Wu
K-Ras mutations at codon 12 play an important role in an early step of carcinogenesis. Here, a label-free colorimetric isothermal cascade amplification for ultrasensitive and specific detection of K-Ras point mutation is developed based on a double-hairpin molecular beacon (DHMB). The biosensor consists of DHMB probe and a primer-incorporated polymerization template (PPT) designed partly complementary to DHMB. In the presence of polymerase, target DNA is designed to trigger strand displacement amplification (SDA) via promote the hybridization of PPT with DHMB and subsequently initiates cascade amplification process with the help of the nicking endonuclease...
March 8, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28103723/scholar-outcomes-for-dental-internship-research-program-in-saudi-arabia-a-qualitative-evaluation
#17
Laila A Bahammam, Amal I Linjawi
OBJECTIVE: To explore the potential, challenges and needs for internship research activities in achieving scholar outcomes among graduates. METHODS: A qualitative general needs assessment and evaluation of an internship research program was conducted at King Abdulaziz University, Faculty of Dentistry (KAUFD), KSA, from December 2014 to February 2015 using focus groups and interviews. The participants included: administrates, faculty, and internship students. Data were transcribed and analyzed following the grounded theory...
January 20, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28102397/highly-exposed-fe-n4-active-sites-in-porous-poly-iron-phthalocyanine-based-oxygen-reduction-electrocatalyst-with-ultrahigh-performance-for-air-cathode
#18
Ganesan Anandhababu, Syed Comail Abbas, Jiangquan Lv, Kui Ding, Qin Liu, Dickson D Babu, Yiyin Huang, Jiafang Xie, Maoxiang Wu, Yaobing Wang
Progress in the development of efficient electrocatalysts for oxygen reduction reactions is imperative for various energy systems such as metal-air batteries and fuel cells. In this paper, an innovative porous two-dimensional (2D) poly-iron-phthalocyanine (PFe-Pc) based oxygen reduction electrocatalyst created with a simple solid-state chemical reaction without pyrolysis is reported. In this strategy, silicon dioxide nanoparticles play a pivotal role in preserving the Fe-N4 structure during the polymerization process and thereby assist in the development of a porous structure...
January 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28099453/elimination-of-porcine-epidemic-diarrhea-virus-in-an-animal-feed-manufacturing-facility
#19
Anne R Huss, Loni L Schumacher, Roger A Cochrane, Elizabeth Poulsen, Jianfa Bai, Jason C Woodworth, Steve S Dritz, Charles R Stark, Cassandra K Jones
Porcine Epidemic Diarrhea Virus (PEDV) was the first virus of wide scale concern to be linked to possible transmission by livestock feed or ingredients. Measures to exclude pathogens, prevent cross-contamination, and actively reduce the pathogenic load of feed and ingredients are being developed. However, research thus far has focused on the role of chemicals or thermal treatment to reduce the RNA in the actual feedstuffs, and has not addressed potential residual contamination within the manufacturing facility that may lead to continuous contamination of finished feeds...
2017: PloS One
https://www.readbyqxmd.com/read/28098920/-too-long-in-tbs-a-study-on-patients-receiving-forensic-psychiatric-tbs-treatment-for-15-years-or-longer
#20
H Nijman, S Lammers, M Vrinten, E Bulten
In 2013 in the Netherlands about 100 forensic psychiatric patients were treated in tbs-hospitals for 15 years or more.<br/> AIM: To investigate the variables that characterise patients who have been receiving forensic psychiatric treatment (tbs) for 15 years or more, and to obtain insight in which actions might be helpful to facilitate discharge or transfer of such patients to other (mental health care) facilities, according to their caregivers and experts.<br/> METHOD: The group of long-term tbs-patients (n = 97) was compared with regard to diagnostic characteristics, 'basic historical risks' (as assessed by risk assessment instruments), and behaviour  to three other groups of forensic patients: a...
2017: Tijdschrift Voor Psychiatrie
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