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https://www.readbyqxmd.com/read/28110490/high-expression-of-wls-is-associated-with-lymph-node-metastasis-and-advanced-tnm-stage-in-gastric-carcinomas
#1
Wei Zhang, Hong Tao, Xiao Chen, Haruhiko Sugimura, Jiandong Wang, Ping Zhou
The roles of Wnt protein in carcinogenesis have been well documented in human cancers. Wls is a key modulator for the secretion of Wnt protein. We previously found that Wls was aberrantly expressed in colorectal carcinomas. Studies have revealed that dysregulation of Wnt signal transduction plays an important role in gastric carcinoma. We hypothesized that Wls may play a role in the development and progression of gastric carcinoma. In this study, three gastric cancer cell lines MGC-803, SGC-7901, and AGS, and a set of gastric carcinoma tissue specimens were subjected to immunohistochemistry...
January 22, 2017: Pathology International
https://www.readbyqxmd.com/read/28110477/recognition-in-context-implications-for-trade-mark-law
#2
Michael S Humphreys, Kimberley A McFarlane, Jennifer S Burt, Sarah J Kelly, Kimberlee G Weatherall, Robert G Burrell
Context effects in recognition have played a major role in evaluating theories of recognition. Understanding how context impacts recognition is also important for making sound trade mark law. Consumers attempting to discriminate between the brand they are looking for and a look-alike product often have to differentiate products which share a great deal of common context: positioning on the supermarket shelf, the type of store, aspects of the packaging, or brand claims. Trade mark and related laws aim to protect brands and reduce consumer confusion, but courts assessing allegations of trade mark infringement often lack careful empirical evidence concerning the impact of brand and context similarity, and, in the absence of such evidence, make assumptions about how consumers respond to brands that downplay the importance of context and focus on the similarity of registered marks...
January 21, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28110471/depletion-of-mitofusin-2-causes-mitochondrial-damage-in-cisplatin-induced-neuropathy
#3
Ilja Bobylev, Abhijeet R Joshi, Mohammed Barham, Wolfram F Neiss, Helmar C Lehmann
Sensory neuropathy is a relevant side effect of the antineoplastic agent cisplatin. Mitochondrial damage is assumed to play a critical role in cisplatin-induced peripheral neuropathy, but the pathomechanisms underlying cisplatin-induced mitotoxicity and neurodegeneration are incompletely understood. In an animal model of cisplatin-induced neuropathy, we determined in detail the extent and spatial distribution of mitochondrial damage during cisplatin treatment. Changes in the total number of axonal mitochondria during cisplatin treatment were assessed in intercostal nerves from transgenic mice that express cyan fluorescent protein...
January 21, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28110430/ontological-issues-and-the-possible-development-of-cultural-psychology
#4
Gilberto Pérez-Campos
Ontological issues have a bad reputation within mainstream psychology. This paper, however, is an attempt to argue that ontological reflection may play an important role in the development of cultural psychology. A cross-reading of two recent papers on the subject (Mammen & Mironenko, Integrative Psychological and Behavioral Science, 49(4), 681-713, 2015; Simão Integrative Psychological and Behavioral Science, 50, 568-585, 2016), aimed at characterizing their respective approaches to ontological issues, sets the stage for a presentation of Cornelius Castoriadis' ontological reflections...
January 21, 2017: Integrative Psychological & Behavioral Science
https://www.readbyqxmd.com/read/28110427/evaluation-of-inos-icam-1-and-vcam-1-gene-expression-a-study-of-adult-t-cell-leukemia-malignancy-associated-with-htlv-1
#5
Mahdokht Jafarian, Sayed-Hamidreza Mozhgani, Elham Patrad, Hamidreza Vaziri, Seyed Abdolrahim Rezaee, Mohammad Mehdi Aakbarin, Mehdi Norouzi
The main aim of this study was to evaluate the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and inducible nitric oxide synthase (iNOS) as host factors, and proviral load as the viral parameter, in adult T-cell leukemia/lymphoma (ATLL) individuals and healthy carrier (HC(s)) groups. Peripheral blood mononuclear cells (PBMC) from ATLL patients (n = 17) and HC subjects (as the control group, n = 17) were evaluated using real-time PCR to determine the levels of HTLV-1 proviral load and mRNA expression of ICAM, VCAM-1, and iNOS...
January 21, 2017: Archives of Virology
https://www.readbyqxmd.com/read/28110414/expression-of-the-citrus-cstip2-1-gene-improves-tobacco-plant-growth-antioxidant-capacity-and-physiological-adaptation-under-stress-conditions
#6
Cristina P S Martins, Diana M Neves, Luciana C Cidade, Amanda F S Mendes, Delmira C Silva, Alex-Alan F Almeida, Mauricio A Coelho-Filho, Abelmon S Gesteira, Walter S Soares-Filho, Marcio G C Costa
Overexpression of the citrus CsTIP2;1 improves plant growth and tolerance to salt and drought stresses by enhancing cell expansion, H 2 O 2 detoxification and stomatal conductance. Tonoplast intrinsic proteins (TIPs) are a subfamily of aquaporins, belonging to the major intrinsic protein family. In a previous study, we have shown that a citrus TIP isoform, CsTIP2;1, is highly expressed in leaves and also transcriptionally regulated in leaves and roots by salt and drought stresses and infection by 'Candidatus Liberibacter asiaticus', the causal agent of the Huanglongbing disease, suggesting its involvement in the regulation of the flow of water and nutrients required during both normal growth and stress conditions...
January 21, 2017: Planta
https://www.readbyqxmd.com/read/28110404/microrna-150-targets-elk1-and-modulates-the-apoptosis-induced-by-ox-ldl-in-endothelial-cells
#7
Bing Qin, Yaqing Shu, Li Xiao, Tingting Lu, Yinyao Lin, Huan Yang, Zhengqi Lu
Atherosclerosis, a chronic inflammatory disease, is the major cause of life-threatening complications such as myocardial infarction and stroke. Endothelial cells (ECs) apoptosis plays a vital role in the initiation and progression of atherosclerosis. Although a subset of microRNAs (miRNAs) have been identified as critical regulators of atherosclerosis, studies on their participation in endothelial apoptosis in atherosclerosis have been limited. In the current study, we show that miRNA-150 (miR-150) expression was substantially up-regulated during the oxidized low-density lipoprotein (ox-LDL)-induced apoptosis in human umbilical cord vein endothelial cells (HUVECs)...
January 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28110397/enhancement-of-acetate-productivity-in-a-thermophilic-55%C3%A2-%C3%A2-c-hollow-fiber-membrane-biofilm-reactor-with-mixed-culture-syngas-h2-co2-fermentation
#8
Yun-Qi Wang, Shi-Jin Yu, Fang Zhang, Xiu-Yang Xia, Raymond J Zeng
Conversion of organic wastes to syngas is an attractive way to utilize wastes. The produced syngas can be further used to produce a variety of chemicals. In this study, a hollow-fiber membrane biofilm reactor with mix cultures was operated at 55 °C to convert syngas (H2/CO2) into acetate. A high concentration of acetate (42.4 g/L) was reached in batch experiment while a maximum acetate production rate of 10.5 g/L/day was achieved in the continuous-flow mode at hydraulic retention time (HRT) of 1 day. Acetate was the main product in both batch and continuous-flow experiments...
January 21, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28110391/social-media-for-patients-benefits-and-drawbacks
#9
REVIEW
Ivan De Martino, Rocco D'Apolito, Alexander S McLawhorn, Keith A Fehring, Peter K Sculco, Giorgio Gasparini
PURPOSE OF REVIEW: Social media is increasingly utilized by patients to educate themselves on a disease process and to find hospital, physicians, and physician networks most capable of treating their condition. However, little is known about quality of the content of the multiple online platforms patients have to communicate with other potential patients and their potential benefits and drawbacks. RECENT FINDINGS: Patients are not passive consumers of health information anymore but are playing an active role in the delivery of health services through an online environment...
January 21, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28110369/neuroradiology-of-human-prion-diseases-diagnosis-and-differential-diagnosis
#10
REVIEW
Simona Gaudino, Emma Gangemi, Raffaella Colantonio, Annibale Botto, Emanuela Ruberto, Rosalinda Calandrelli, Matia Martucci, Maria Gabriella Vita, Carlo Masullo, Alfonso Cerase, Cesare Colosimo
Human transmissible spongiform encephalopathies (TSEs), or prion diseases, are invariably fatal conditions associated with a range of clinical presentations. TSEs are classified as sporadic [e.g. sporadic Creutzfeldt-Jakob disease (sCJD), which is the most frequent form], genetic (e.g. Gerstmann-Straussler-Scheinker disease, fatal familial insomnia, and inherited CJD), and acquired or infectious (e.g. Kuru, iatrogenic CJD, and variant CJD). In the past, brain imaging played a supporting role in the diagnosis of TSEs, whereas nowadays magnetic resonance imaging (MRI) plays such a prominent role that MRI findings have been included in the diagnostic criteria for sCJD...
January 21, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28110318/genetic-variation-of-the-psca-gene-rs2294008-is-not-associated-with-the-risk-of-prostate-cancer
#11
Lee Il-Seok, Pil Seo Sung, Sok Ha Yun, Jeong Pildu, Won Kang Ho, Tae Kim Won, Kim Yong-June, Joong Yun Seok, Cheol Lee Sang, Kim Wun-Jae
Prostate stem cell antigen (PSCA) is a cell-membrane glycoprotein consisting of 123 amino acids and highly expressed in the prostate, but there have been few reports on the relationship between rs2294008 of PSCA and prostate cancer in the literature. Therefore, we evaluated the association between rs2294008 and the risk of prostate cancer. A total of 240 prostate cancer patients and 306 controls (patients with benign prostatic hyperplasia) were enrolled. Genotype analysis of rs2294008 of PSCA was performed using PCR...
January 19, 2017: Journal of Biomedical Research
https://www.readbyqxmd.com/read/28110237/undoing-the-past-in-order-to-lie-in-the-present-counterfactual-thinking-and-deceptive-communication
#12
Raluca A Briazu, Clare R Walsh, Catherine Deeprose, Giorgio Ganis
This paper explores the proposal that there is a close link between counterfactual thinking and lying. Both require the imagination of alternatives to reality and we describe four studies which explore this link. In Study 1 we measured individual differences in both abilities and found that individuals with a tendency to generate counterfactual thoughts were also more likely to generate potential lies. Studies 2 and 3 showed that counterfactual availability influences people's ability to come up with lies and the extent to which they expect others to lie...
January 19, 2017: Cognition
https://www.readbyqxmd.com/read/28110235/relationship-between-expression-of-vascular-endothelial-growth-factor-and-the-proliferation-of-prolactinomas
#13
Nan Li Ya, ZhiQuan Jiang
OBJECTIVE: Prolactinomas are the most common functional hormone-producing pituitary lesions, accounting for 30-40% of all pituitary tumors, while in autopsy series their incidence reaches 50%. However, patients with prolactinoma had a higher recurrence percentage and rate than patients with acromegaly or Cushing's disease. Furthermore, prolactinomas have the highest rate of recurrence post-surgery as compared with other pituitary adenomas. At present, this behavior of prolactinoma is largely unexplained, but may be related to definition of cure, or to more frequent microscopic tumor infiltration into normal pituitary tissue, which is not removed at surgery...
December 14, 2016: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28110220/hypoxia-inducing-factor-hif-1%C3%AE-derived-peptide-capable-of-inducing-cancer-reactive-cytotoxic-t-lymphocytes-from-hla-a24-patients-with-renal-cell-carcinoma
#14
Takafumi Minami, Naoki Matsumura, Koichi Sugimoto, Nobutaka Shimizu, Marco De Velasco, Masahiro Nozawa, Kazuhiro Yoshimura, Nanae Harashima, Mamoru Harada, Hirotsugu Uemura
Hypoxic tumor microenvironment makes cancer cells to be therapy-resistant and hypoxia-inducing factors (HIFs) play a central role in hypoxic adaptation. Especially, renal cell carcinoma (RCC) is often associated with von Hippel-Lindau (VHL) gene mutations, leading to up-regulation of HIFs. However, from a different point of view, this suggests the possibility that HIFs could be promising targets in anti-cancer therapy. In this study, we searched for HIF-1α-derived peptides that are able to induce RCC-reactive cytotoxic T lymphocytes (CTLs) from HLA-A24(+) RCC patients...
January 19, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28110209/expansion-of-cd11b-ly-6c-myeloid-derived-suppressor-cells-mdscs-driven-by-galectin-9-attenuates-cvb3-induced-myocarditis
#15
Yingying Zhang, Mengying Zhang, Xueqin Li, Zongsheng Tang, Ling He, Kun Lv
Galectin-9 is known to play a role in the modulation of innate and adaptive immunity to ameliorate CVB3-induced myocarditis. In the present study, we found that galectin-9 induced the expansion of CD11b(+)Ly-6C(+) myeloid-derived suppressor cells (MDSCs) in the heart from CVB3-infected mice. Adoptive transfer of CD11b(+)Ly-6C(+) MDSCs significantly alleviated myocarditis accompanied by increased Th2 and Treg frequency and anti-inflammatory cytokines expression in the heart tissue. Moreover, Ly6C(+) MDSCs, but not Ly6G(+) cells, expressed Arg-1 and NOS2, and suppressed CD4(+) T cell proliferation in vitro in an Arg-1-dependent mechanism; an event that was reversed with treatment of either an Arg-1 inhibitor or addition of excess l-arginine...
January 19, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28110206/an-epstein-barr-virus-susceptible-immature-t-cell-line-will4-established-from-a-patient-with-t-lymphoblastic-lymphoma-bearing-cd21-and-a-clonal-ebv-genome
#16
Hiroki Hosoi, Ken-Ichi Imadome, Shinobu Tamura, Kodai Kuriyama, Shogo Murata, Yusuke Yamashita, Toshiki Mushino, Takehiro Oiwa, Hiroshi Kobata, Akinori Nishikawa, Hideki Nakakuma, Nobuyoshi Hanaoka, Yasushi Isobe, Kouichi Ohshima, Takashi Sonoki
We managed a patient with an Epstein-Barr virus-associated T-cell lymphoblastic lymphoma. Mediastinal tumor cells at initial admission were positive for CD4, CD8, and TdT. Interestingly, a lymph node at necropsy was compatible for a CD4-positive peripheral T-cell lymphoma without CD8 and TdT expression, suggesting a different phenotype from the mediastinal tumor. Tumor cells in pleural effusion continued to proliferate in in vitro and were designated as WILL4. WILL4 cells were positive for CD3, CD4, CD8, CD21, T-cell receptor (TcR) αβ, and TdT, indicating a similar phenotype to thymocytes...
January 15, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28110198/variation-of-atmospheric-14-co2-and-its-spatial-distribution
#17
Shugang Wu
The atmospheric (14)CO2 is usually presented in the Δ(14)C notation, which cannot reflect its absolute quantity change. This article presents the atmospheric radiocarbon activity concentrations (aacn, reported in mBq/m(3)) in recent years at nine observation stations. The aacn at Schauinsland decrease from 1977 to 1993 but between 1993 and 2003 keeps at a relative steady state. Atmospheric aacns were higher in the northern hemisphere than that in the southern hemisphere. The aacns in the northern hemisphere show clear seasonal cycle with higher value in winter and lower value in summer, while this seasonality is not obvious in the southern hemisphere...
January 19, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28110160/moderating-and-mediating-effects-of-resilience-between-childhood-trauma-and-depressive-symptoms-in-chinese-children
#18
Huisi Ding, Juan Han, Minli Zhang, Kaiqiao Wang, Jiangling Gong, Senbei Yang
BACKGROUND: Childhood trauma has been regarded as a risk factor for adolescent depression. Resilience has been found to be a protective factor for adolescent mental health. However, it is not clear about the role of resilience in the relationship between childhood trauma and depression. METHODS: School attending adolescents (n=6406) aged 9-17 years were drawn from five primary schools, three middle schools and two high schools in Wuhan city of China in 2015. The participants were invited to complete self-report questionnaires, including demographics, childhood trauma, resilience and depressive symptoms...
January 10, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28110150/enhanced-degradation-of-iopamidol-by-peroxymonosulfate-catalyzed-by-two-pipe-corrosion-products-cuo-and-%C3%AE-mno2
#19
Jun Hu, Huiyu Dong, Jiuhui Qu, Zhimin Qiang
Peroxymonosulfate (PMS) is a promising alternative for drinking water disinfection; also many organic micropollutants may be present in drinking water sources nowadays. However, pipe corrosion products (PCPs) may impact the reactions between a disinfectant and organic micropollutants in water distribution systems. This study investigated iopamidol (IPM) degradation by PMS under catalysis of two PCPs (i.e., CuO and δ-MnO2). The pseudo-first-order rate constant of IPM degradation in the CuO/PMS system (CuPS) was 3...
January 16, 2017: Water Research
https://www.readbyqxmd.com/read/28110144/method-development-for-detecting-the-novel-cyanide-antidote-dimethyl-trisulfide-from-blood-and-brain-and-its-interaction-with-blood
#20
Lóránd Kiss, Secondra Holmes, Ching-En Chou, Xinmei Dong, James Ross, Denise Brown, Brooke Mendenhall, Valerie Coronado, Deepthika De Silva, Gary A Rockwood, Ilona Petrikovics, David E Thompson
The antidotal potency of dimethyl trisulfide (DMTS) against cyanide poisoning was discovered and investigated in our previous studies. Based on our results it has better efficacy than the Cyanokit and the Nithiodote therapies that are presently used against cyanide intoxication in the US. Because of their absence in the literature, the goal of this work was to develop analytical methods for determining DMTS from blood and brain that could be employed in future pharmacokinetic studies. An HPLC-UV method for detection of DMTS from blood, a GC-MS method for detection of DMTS from brain, and associated validation experiments are described here...
January 9, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
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