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https://www.readbyqxmd.com/read/28638707/sexual-dysfunction-in-female-patients-with-relapsing-remitting-multiple-sclerosis
#1
Pawel Bartnik, Aleksandra Wielgoś, Joanna Kacperczyk, Katarzyna Pisarz, Iwona Szymusik, Aleksandra Podlecka-Piętowska, Beata Zakrzewska-Pniewska, Miroslaw Wielgoś
INTRODUCTION: Sexual dysfunction (SD) is one of the common symptoms of multiple sclerosis (MS) and is often underdiagnosed, especially in women. Relapsing-remitting multiple sclerosis (RRMS) is the most widespread form of the disease, but the data on SD occurrence in this particular group of patients is limited. The aim of the study was to analyze the associations between demographic factors, symptoms and signs of MS, psychiatric comorbidities and SD in female patients with RRMS. MATERIAL & METHODS: A subgroup of 86 sexually active women with RRMS out of 218 total MS respondents was analyzed...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28637044/depressed-patients-hospitalized-in-southeast-facing-rooms-are-discharged-earlier-than-patients-in-northwest-facing-rooms
#2
Krzysztof Gbyl, Helle Østergaard Madsen, Signe Dunker Svendsen, Paul Michael Petersen, Ida Hageman, Carlo Volf, Klaus Martiny
BACKGROUND AND AIM: Improvement in patients admitted to inpatient wards with severe depression is slow, and such patients are often discharged with residual symptoms which put them at risk for relapse. New treatments that can speed up recovery are highly desired. This naturalistic follow-up study in a specialized affective disorders unit investigated the impact of daylight on the length of hospital stay and improvement of depression. METHODS: For a period of 1 year, we collected data on sociodemographics, length of stay, vitamin D, and depression severity for patients in an inpatient affective disorders unit...
June 22, 2017: Neuropsychobiology
https://www.readbyqxmd.com/read/28627459/peripheral-blood-gene-expression-of-acute-phase-proteins-in-people-with-first-episode-psychosis
#3
Jie Yin Yee, Milawaty Nurjono, Wai Yee Ng, Stephanie Ruth Teo, Tih-Shih Lee, Jimmy Lee
BACKGROUND: There is a growing interest in the association between schizophrenia and the activation of inflammatory system with signs of acute phase (AP) response. Majority of such studies had focused on C-reactive protein (CRP). The aims of the present study were (i) to examine the gene expression profiles of other acute phase proteins (APP), namely haptoglobin (HP), alpha-1 antitrypsin (A1T), and alpha-2 macroglobulin (A2M) in patients with first episode psychosis (FEP) over a period of three months and (ii) to explore the association between APP levels and severity of symptoms...
June 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28618721/the-relationship-between-sleep-quality-and-depressive-symptoms-in-adolescents
#4
Begüm Dağ, Fatma Yasemin Kutlu
BACKGROUND/AIM: While poor sleep quality and sleep problems are signs of depression in adolescents, depressive symptoms among this age group further deteriorate sleep quality. The aim of this study was to explore the relationship between sleep quality and depressive symptoms in adolescents of 14 to 20 years of age. MATERIALS AND METHODS: This study was conducted with a descriptive and cross-sectional research design. The sample group consisted of 313 adolescents in İstanbul, Turkey...
June 12, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28602449/what-are-the-barriers-and-facilitators-for-the-self-management-of-chronic-pain-with-and-without-neuropathic-characteristics
#5
Elizabeth G Mann, Margaret B Harrison, Sandra LeFort, Elizabeth G VanDenKerkhof
Chronic pain requires affected individuals to self-manage their health. This study compared barriers and facilitators of self-management in two groups of people with chronic pain: those with and without neuropathic characteristics. A cross-sectional survey study of community-dwelling Canadians was conducted. The sample (n = 710) included randomly selected participants who reported chronic pain. The Self-Report Leeds Assessment of Neuropathic Symptoms and Signs was used to screen for neuropathic characteristics...
June 8, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/28597913/inherent-vulnerabilities-in-monoaminergic-pathways-predict-the-emergence-of-depressive-impairments-in-an-animal-model-of-chronic-epilepsy
#6
Jesús-Servando Medel-Matus, Don Shin, Raman Sankar, Andrey Mazarati
The objective was to determine whether the depression comorbid with epilepsy could be predicted based on inherent premorbid patterns of monoaminergic transmission. In male Wistar rats, despair-like and anhedonia-like behaviors were examined using forced swimming and taste preference tests, respectively. Serotonergic raphe nucleus (RN)-prefrontal cortex (PFC) and dopaminergic ventral tegmental area (VTA)-nucleus accumbens (NAcc) pathways were interrogated by fast scan cyclic voltammetry (FSCV). The assays were performed before and 2 months after pilocarpine status epilepticus...
June 9, 2017: Epilepsia
https://www.readbyqxmd.com/read/28581315/moral-injury-posttraumatic-stress-disorder-and-suicidal-behavior-among-national-guard-personnel
#7
Craig J Bryan, AnnaBelle O Bryan, Erika Roberge, Feea R Leifker, David C Rozek
OBJECTIVE: To empirically examine similarities and differences in the signs and symptoms of posttraumatic stress disorder (PTSD) and moral injury and to determine if the combination of these 2 constructs is associated with increased risk for suicidal thoughts and behaviors in a sample of U.S. National Guard personnel. METHOD: 930 National Guard personnel from the states of Utah and Idaho completed an anonymous online survey. Exploratory structural equation modeling (ESEM) was used to test a measurement model of PTSD and moral injury...
June 5, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28580529/abnormal-baseline-brain-activity-in-alzheimer-s-disease-patients-with-depression-a-resting-state-functional-magnetic-resonance-imaging-study
#8
Xiaozheng Liu, Zhongwei Guo, Yanping Ding, Jiapeng Li, Gang Wang, Hongtao Hou, Xingli Chen, Enyan Yu
PURPOSE: As one of the most common mental disorders and the most important precursor of suicide in Alzheimer's disease (AD), depression is associated with a decline in both well-being and daily functioning. At present, the diagnosis of AD patients with depression (D-AD) is largely dependent on clinical signs and symptoms, and the precise neural correlate underlying D-AD is still not fully understood. METHODS: The current study sought to investigate low-frequency oscillations at the voxel level in D-AD patients based on the amplitude of low-frequency fluctuations (ALFF) measured using resting-state functional magnetic resonance imaging...
June 3, 2017: Neuroradiology
https://www.readbyqxmd.com/read/28578740/application-of-network-methods-for-understanding-mental-disorders-pitfalls-and-promise
#9
S Guloksuz, L-K Pries, J van Os
Galvanized with the availability of sophisticated statistical techniques and large datasets, network medicine has emerged as an active area of investigation. Following this trend, network methods have been utilized to understand the interplay between symptoms of mental disorders. This realistic approach that may provide an improved framework into understanding mental conditions and underlying mechanisms is certainly to be welcomed. However, we have noticed that symptom network studies tend to lose sight of the fundamentals, overlook major limitations embedded in study designs, and make inferences that are difficult to justify with current findings...
June 5, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28574973/depressive-symptoms-moderate-the-association-between-appetite-and-health-status-in-patients-with-heart-failure
#10
Christina Andreae, Anna Strömberg, Misook L Chung, Carina Hjelm, Kristofer Årestedt
BACKGROUND: Decreased appetite and depressive symptoms are clinical problems in patients with heart failure. Both may result in impaired health status. OBJECTIVE: The aims of this study were to investigate the association between appetite and health status in patients with heart failure and to explore whether depressive symptoms moderate this association. METHODS: In this cross-sectional study, patients with heart failure (n = 186; mean age, 71 years), New York Heart Association class II to IV, participated...
June 1, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28567288/gad-antibody-associated-limbic-encephalitis-in-a-young-woman-with-apeced
#11
Anna Kopczak, Adrian-Minh Schumacher, Sandra Nischwitz, Tania Kümpfel, Günter K Stalla, Matthias K Auer
The autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) syndrome is a genetic disorder caused by a mutation in the autoimmune regulator (AIRE) gene. Immune deficiency, hypoparathyroidism and Addison's disease due to autoimmune dysfunction are the major clinical signs of APECED. We report on a 21-year-old female APECED patient with two inactivating mutations in the AIRE gene. She presented with sudden onset of periodic nausea. Adrenal insufficiency was diagnosed by means of the ACTH stimulation test...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28553145/anxiety-and-depression-in-patients-with-endometriosis-impact-and-management-challenges
#12
REVIEW
Antonio Simone Laganà, Valentina Lucia La Rosa, Agnese Maria Chiara Rapisarda, Gaetano Valenti, Fabrizio Sapia, Benito Chiofalo, Diego Rossetti, Helena Ban Frangež, Eda Vrtačnik Bokal, Salvatore Giovanni Vitale
Endometriosis is one of the most common gynecological diseases and affects ~10% of women in reproductive age. The most common clinical signs of endometriosis are menstrual irregularities, chronic pelvic pain (CPP), dysmenorrhea, dyspareunia and infertility. Symptoms of endometriosis often affect psychological and social functioning of patients. For this reason, endometriosis is considered as a disabling condition that may significantly compromise social relationships, sexuality and mental health. Considering this point, the aim of this narrative review is to elucidate the impact of anxiety and depression in the management of women with endometriosis...
2017: International Journal of Women's Health
https://www.readbyqxmd.com/read/28553087/association-of-dry-eye-disease-with-psychiatric-or-neurological-disorders-in-elderly-patients
#13
REVIEW
Sang Beom Han, Hee Kyung Yang, Joon Young Hyon, Won Ryang Wee
Dry eye disease (DED) is a common disease that can impair quality of life significantly. Its prevalence increases with advancing age, and the economic burden of the disease on both a patient and the society is increasing with elongation of life expectancy. The diagnosis and treatment of DED are often difficult due to the discordance between symptoms and signs of the disease. Recent studies have suggested the role of neurological or psychological factors in the development of dry eye symptoms and discrepancy of the symptoms and signs, particularly in elderly patients...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28542780/baseline-dimensional-psychopathology-and-future-mood-disorder-onset-findings-from-the-dutch-bipolar-offspring-study
#14
E Mesman, W A Nolen, L Keijsers, M H J Hillegers
OBJECTIVE: To identify the early signs of mood disorder development, specifically bipolar disorder (BD), in a population at familial risk for BD. METHOD: The sample included 107 Dutch adolescent bipolar offspring (age 12-21) followed into adulthood (age 22-32). Lifetime DSM-IV axis I diagnoses were examined at baseline, 1-, 5-, and 12- year follow-up. Symptoms were assessed at baseline on a 3-point Likert scale at baseline with the K-SADS-PL and were analyzed using symptom and sum scores...
May 20, 2017: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28533149/prevalence-and-characteristics-of-catatonia-on-admission-to-an-acute-geriatric-psychiatry-ward
#15
Jorge Cuevas-Esteban, Maria Iglesias-González, Maria Rubio-Valera, Jordi Serra-Mestres, Antoni Serrano-Blanco, Luisa Baladon
BACKGROUND: This study aims to describe the prevalence of catatonia in a population of older acute psychiatric inpatients according to different diagnostic criteria. Secondary objectives are: to compare the catatonic symptom profile, prevalence, and severity, in respect to the underlying aetiology, and to evaluate the association between catatonic and somatic comorbidity. METHODS: The study included 106 patients admitted to an acute geriatric psychiatry ward. Catatonia was assessed using the Bush Francis Catatonia Rating Scale (BFCRS)...
May 19, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28532165/16p11-2-microduplication-and-associated-symptoms-a-case-study
#16
Martin Knoll, Kirsten Arnett, Jeremy Hertza
The minimal amount known regarding chromosomal microduplications and microdeletions presents a fascinating new direction of research into better understanding misunderstood symptoms and overall genomic influence. Specifically, the 16p11.2 microduplication has been associated with a myriad of possible cognitive, physical, and emotional symptoms. The purpose of this study is to inform the reader of the biological basis of the 16p11.2 microduplication, review sources that suggest a link between the microduplication and clinically relevant diagnoses/sources of impairment, and to better understand the implications and development of symptoms through the illustration of a case example...
May 22, 2017: Applied Neuropsychology. Child
https://www.readbyqxmd.com/read/28516474/relationship-between-pain-and-motor-and-non-motor-symptoms-in-parkinson-s-disease
#17
G Defazio, A Antonini, M Tinazzi, A F Gigante, S Pietracupa, R Pellicciari, M Bloise, R Bacchin, A Marcante, G Fabbrini, A Berardelli
BACKGROUND AND PURPOSE: Although female gender, depressive symptoms and medical conditions predisposing to pain are more common in patients with Parkinson's disease (PD) with pain, no study has yet explored the relationship between pain and other non-motor symptoms (NMS). METHODS: A total of 321 consecutive patients with PD [190 men/131 women aged 68.3 (SD 9.2) years] attending four Italian movement disorder clinics were studied. Demographic/clinical data were obtained by a standardized interview and the NMS scale...
May 18, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/28514463/pediatric-psoriasis-comorbidity-screening-guidelines
#18
Emily Osier, Audrey S Wang, Megha M Tollefson, Kelly M Cordoro, Stephen R Daniels, Andrew Eichenfield, Joel M Gelfand, Alice B Gottlieb, Alexa B Kimball, Mark Lebwohl, Nehal N Mehta, Amy S Paller, Jeffrey B Schwimmer, Dennis M Styne, Abby S Van Voorhees, Wynnis L Tom, Lawrence F Eichenfield
Importance: Psoriasis is a complex inflammatory skin condition associated with serious medical comorbidities in adults, including obesity, hypertension, dyslipidemia, type 2 diabetes mellitus, psoriatic arthritis, nonalcoholic fatty liver disease, depression, anxiety, and decreased quality of life. Because psoriasis begins in childhood in almost one-third of patients, early identification of risk may be critical to minimizing effects on future health. Objective: To develop the first set of guidelines for comorbidity screening for patients with pediatric psoriasis based on current evidence...
May 17, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28507604/health-related-quality-of-life-outcomes-from-botulinum-toxin-treatment-in-hemifacial-spasm
#19
Daniel Weiss, Justine Sturm, Leonhard Hieber, Axel Börtlein, Ingo Mayr, Matthias Appy, Benedicta Kühnler, Joachim Buchthal, Christian Dippon, Guy Arnold, Tobias Wächter
BACKGROUND: Although botulinum neurotoxin (BoNT) injections may alleviate involuntary muscle contractions in hemifacial spasm substantially, it is less clear whether the motor effect would translate into improvements of health-related quality of life (HR-QoL). METHODS: In this open-label clinical observational study, we characterized outcomes on HR-QoL in terms of the EuroQol (EQ-5D-5L) from BoNT in a prospective cohort of patients with hemifacial spasm (n = 73)...
April 2017: Therapeutic Advances in Neurological Disorders
https://www.readbyqxmd.com/read/28500512/molecular-adaptations-to-social-defeat-stress-and-induced-depression-in-mice
#20
Natalya Bondar, Leonid Bryzgalov, Nikita Ershov, Fedor Gusev, Vasiliy Reshetnikov, Damira Avgustinovich, Mikhail Tenditnik, Evgeny Rogaev, Tatiana Merkulova
Chronic stress is a risk factor for major depression. Social defeat stress is a well-validated murine model of depression. However, little is known about the gene activity dynamics during the development of a depression-like state. We analyzed the effects of social defeat stress of varying duration (10 and 30 days) on the behavioral patterns and prefrontal-cortex transcriptome of C57BL/6 mice. The 10-day exposure to social defeat stress resulted in a high level of social avoidance with no signs of depression-associated behavior...
May 12, 2017: Molecular Neurobiology
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