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https://www.readbyqxmd.com/read/29929614/troponin-release-and-reversible-left-ventricular-dysfunction-after-transient-pressure-overload
#1
Brian R Weil, Gen Suzuki, Rebeccah F Young, Vijay Iyer, John M Canty
BACKGROUND: The authors previously demonstrated that brief ischemia elicits cardiac troponin I (cTnI) release and myocyte apoptosis in the absence of necrosis. It remains uncertain whether other pathophysiological stresses can produce apoptosis and transient cTnI release without ischemia. OBJECTIVES: This study sought to determine whether a transient increase in left ventricular (LV) preload elicits cTnI release in the absence of ischemia. METHODS: Propofol-anesthetized swine (N = 13) received intravenous phenylephrine (PE) (300 μg/min) for 1 h to increase left ventricular end-diastolic pressure (LVEDP) to ∼30 mm Hg...
June 26, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29923970/vortioxetine-overdose-in-a-suicidal-attempt-a-case-report
#2
Mario Gennaro Mazza, Aurora Rossetti, Eugenia Rossana Botti, Massimo Clerici
RATIONALE: Vortioxetine is a new multimodal antidepressant approved by the Food and Drug Administration for the treatment of Major Depressive Disorder and recently introduced in Europe. While antidepressant properties of vortioxetine and its tolerability have been demonstrated by preclinical and clinical studies data on the safety of vortioxetine after overdose are still lacking. PATIENT CONCERNS: A 50-year-old Caucasian man presenting a severe depressive episode that in a suicide attempt he took vortioxetine at 250 mg...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29916756/association-of-risk-factors-with-temporomandibular-disorders-in-the-northern-finland-birth-cohort-1966
#3
Päivi Jussila, Jarno Knuutila, Sampo Salmela, Ritva Näpänkangas, Jari Päkkilä, Pertti Pirttiniemi, Aune Raustia
OBJECTIVE: To investigate the association between risk factors and pain-related symptoms and clinical signs of temporomandibular disorders (TMD) in Northern Finland Birth Cohort (NFBC) 1966. MATERIAL AND METHODS: A total of 1962 subjects (1050 women, 912 men) attended the follow-up study. The questionnaires included the subjects' background information concerning living conditions and general health, socioeconomic factors, and dental health. The clinical examination was performed using the modified protocol of Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) presented at the International Association for Dental Research (IADR) Conference in 2010...
June 19, 2018: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/29913994/patients-referred-from-a-multidisciplinary-pain-clinic-to-the-social-worker-their-general-health-pain-condition-treatment-and-outcome
#4
Heli Aho, Timo Kauppila, Maija Haanpää
Background and aims As far as we know, the range of issues particular to social work, when working with clients at a pain clinic has not been previously researched. Methods A retrospective study of referrals at the multidisciplinary Pain Clinic of Helsinki University Central Hospital was conducted based on medical records, focusing on pain conditions, treatments and patient flow. Variables used were age, gender, pain conditions, treatment interventions, pain duration and intensity, disruption in everyday life due to pain, psychiatric co-morbidities, referrals, outside care providers, post-treatment care and health habits...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913751/parenteral-opioids-in-emergency-medicine-a-systematic-review-of-efficacy-and-safety
#5
Leila Niemi-Murola, Jani Unkuri, Katri Hamunen
Introduction and aim Pain is a frequent symptom in emergency patients and opioids are commonly used to treat it at emergency departments and at pre-hospital settings. The aim of this systematic review is to examine the efficacy and safety of parenteral opioids used for acute pain in emergency medicine. Method Qualitative review of randomized controlled trials (RCTs) on parenteral opioids for acute pain in adult emergency patients. Main outcome measures were: type and dose of the opioid, analgesic efficacy as compared to either placebo or another opioid and adverse effects...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913681/long-term-efficacy-of-spironolactone-on-pain-mood-and-quality-of-life-in-women-with-fibromyalgia-an-observational-case-series
#6
Heinrich Wernze, Thomas Herdegen
Objective No single drug is broadly efficacious in the long-term treatment of fibromyalgia syndrome (FMS). Spironolactone is known to ameliorate mood and tension headache or migraine in women with premenstrual syndrome or clinical signs of hyperandrogenism. In a case series of women with treatment resistant FMS spironolactone was therefore added to their medication, and they were observed for at least 12 months. Methods 31 women with treatment-resistant FMS received spironolactone as add-on medication to various pain modulating drugs...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29909806/age-and-sex-differences-in-hearing-loss-association-with-depressive-symptoms-analyses-of-nhanes-2011-2012
#7
Franco Scinicariello, Jennifer Przybyla, Yulia Carroll, John Eichwald, John Decker, Patrick N Breysse
BACKGROUND: Depression is a common and significant health problem. Hearing loss is the third most common chronic physical condition in the USA and might be a factor in depression. To determine whether hearing loss is associated with depressive symptoms in US adults ages 20-69 years. METHODS: National Health and Nutrition Examination Survey (NHANES) data (2011-2012) were used to assess the potential relationship between hearing loss and depression, in adults (20-69 years) who answered the Patient Health Questionnaire (PHQ-9) depression screening module, with pure tone audiometry measurements, and complete information on the co-variates data (n = 3316)...
June 18, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29891065/cerebellar-mutism-syndrome
#8
Coriene Catsman-Berrevoets, Zoltan Patay
Cerebellar mutism most commonly, but not exclusively, develops in children after surgery for midline cerebellar or intraventricular tumors in the posterior fossa, typically medulloblastoma. Cerebellar mutism syndrome (CMS) comprises a complex set of neurologic and neurocognitive signs and symptoms, the cardinal and central component of which is an initially profound but usually reversible speech disorder. As such, CMS is currently recognized as an extreme form of the so-called cerebellar cognitive affective syndrome (Schmahmann syndrome)...
2018: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/29883833/rapid-eye-movement-sleep-behavior-disorder-and-the-link-to-alpha-synucleinopathies
#9
REVIEW
Daniel A Barone, Claire Henchcliffe
Rapid eye movement (REM) sleep behavior disorder (RBD) involves REM sleep without atonia in conjunction with a recurrent nocturnal dream enactment behavior, with vocalizations such as shouting and screaming, and motor behaviors such as punching and kicking. Secondary RBD is well described in association with neurological disorders including Parkinson's disease (PD), multiple system atrophy (MSA), and other conditions involving brainstem structures such as tumors. However, RBD alone is now considered to be a potential harbinger of later development of neurodegenerative disorders, in particular PD, MSA, dementia with Lewy bodies (DLB), and pure autonomic failure...
May 29, 2018: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29869583/the-efficacy-of-exercise-referral-as-an-intervention-for-irish-male-prisoners-presenting-with-mental-health-symptoms
#10
Shay O'Toole, Jim Maguire, Pearse Murphy
Purpose The use of exercise as an intervention to improve health in the general population is well documented. The purpose of this paper is to explore whether an exercise referral scheme can be an effective health promotion tool for male prisoners in Ireland, presenting with mental health symptoms. Design/methodology/approach This mixed methods study with a pre- and post-intervention design was conducted in Mountjoy Prison, Dublin, which has a capacity for approximately 790 prisoners. Reliable and validated symptom assessment scales were used to assess levels of depression, anxiety, stress, self-esteem and anger amongst a sample of 40 prisoners pre- and post-intervention...
June 11, 2018: International Journal of Prisoner Health
https://www.readbyqxmd.com/read/29857495/from-e-health-to-i-health-prospective-reflexions-on-the-use-of-intelligent-systems-in-mental-health-care
#11
Xavier Briffault, Margot Morgiève, Philippe Courtet
Depressive disorders cover a set of disabling problems, often chronic or recurrent. They are characterized by a high level of psychiatric and somatic comorbidities and represent an important public health problem. To date, therapeutic solutions remain unsatisfactory. For some researchers, this is a sign of decisive paradigmatic failure due to the way in which disorders are conceptualized. They hypothesize that the symptoms of a categorical disorder, or of different comorbid disorders, can be interwoven in chains of interdependencies on different elements, of which it would be possible to act independently and synergistically to influence the functioning of the symptom system, rather than limiting oneself to targeting a hypothetical single underlying cause...
May 31, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29848408/occurrence-of-chronic-stage-chikungunya-in-the-general-population-of-martinique-during-the-first-2014-epidemic-a-prospective-epidemiological-study
#12
Brieg Couzigou, Anne Criquet-Hayot, Emilie Javelle, Sandrine Tignac, Edith Mota, François Rigaud, Alizé Alain, Odile Troisgros, Sandrine Pierre-Francois, Sylvie Abel, Rishika Banydeen, André Cabié
Chronic stage chikungunya (CHIK), defined by persisting symptoms more than 3 months after initial diagnosis of acute infection, is frequent. However, its burden and impact have rarely been described prospectively in a general population during an ongoing epidemic in the Caribbean. From January 2014 to January 2015, a severe CHIK outbreak occurred in Martinique. Our objective was to describe epidemiological characteristics and outcomes of chronic stage CHIK in its local population. Participants, clinically diagnosed with probable CHIK infection, were included prospectively by general practitioners during the epidemic's peak from April to October 2014...
May 29, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29802146/risk-score-to-predict-need-for-intensive-care-in-initially-hemodynamically-stable-adults-with-non-st-segment-elevation-myocardial-infarction
#13
Alexander C Fanaroff, Anita Y Chen, Laine E Thomas, Karen S Pieper, Kirk N Garratt, Eric D Peterson, L Kristin Newby, James A de Lemos, Mikhail N Kosiborod, Ezra A Amsterdam, Tracy Y Wang
BACKGROUND: Intensive care unit (ICU) use for initially stable patients presenting with non-ST-segment-elevation myocardial infarction (NSTEMI) varies widely across hospitals and minimally correlates with severity of illness. We aimed to develop a bedside risk score to assist in identifying high-risk patients with NSTEMI for ICU admission. METHODS AND RESULTS: Using the Acute Coronary Treatment and Intervention Outcomes Network (ACTION) Registry linked to Medicare data, we identified patients with NSTEMI aged ≥65 years without cardiogenic shock or cardiac arrest on presentation...
May 25, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29788128/sleep-patterns-and-problems-among-army-national-guard-soldiers
#14
Lucas P Hansen, Caroline Kinskey, Erin Koffel, Melissa Polusny, John Ferguson, Sonja Schmer-Galunder, Christopher R Erbes
Introduction: Adequate sleep plays an integral role in the physical and mental health of individuals, while simultaneously influencing their cognitive and work performance. Having recognized this, the U.S. Army has focused efforts on improving soldiers' healthy sleep behaviors. This study examines the extent to which mental health, alcohol use, and certain sleep hygiene behaviors predict sleep problems within an Army National Guard sample (N = 438). Materials and Methods: This manuscript is part of a larger study approved through the Minneapolis Veterans Affairs Medical Center Institutional Review Board...
May 18, 2018: Military Medicine
https://www.readbyqxmd.com/read/29785673/the-impact-of-transcranial-direct-current-stimulation-tdcs-on-bipolar-depression-mania-and-euthymia-a-systematic-review-of-preliminary-data
#15
Clément Dondé, Nicholas H Neufeld, Pierre A Geoffroy
The neurobiological basis of bipolar disorders (BD) has received increased attention and several brain regions and brain circuits have been correlated with clinical symptoms. These brain regions and circuits may represent targets for neuromodulation techniques such as transcranial Direct Current Stimulation (tDCS). We systematically reviewed the literature to explore the risks and benefits of tDCS in BD and examined all mood states. Following the PRISMA guidelines, a systematic literature search using several databases was performed from April 2002 to June 2017...
May 21, 2018: Psychiatric Quarterly
https://www.readbyqxmd.com/read/29775691/pain-in-maintenance-hemodialysis-patients-a-multicenter-study
#16
Tatiana Talya Fleishman, Jacob Dreiher, Pesach Shvartman
CONTEXT: Pain is a common complaint in maintenance hemodialysis (MHD) patients, yet is often inadequately assessed and undertreated. OBJECTIVES: To evaluate the prevalence, characteristics, intensity, and impact of pain in MHD patients. METHODS: In a cross-sectional study conducted between 2013 and 2015, 336 MHD patients from five hemodialysis units in hospitals owned by Clalit were interviewed and evaluated. Study tools included the Brief Pain Inventory, The Leeds Assessment of Neuropathic Symptoms and Signs pain scale, demographic and clinical characteristics...
May 15, 2018: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29767911/analysis-of-the-concept-of-powerlessness-in-individuals-with-stroke
#17
Renan Alves Silva, Álissan Karine Lima Martins, Natália Barreto de Castro, Anna Virgínia Viana, Howard Karl Butcher, Viviane Martins da Silva
OBJECTIVES: To identify and analyze the concept of the powerlessness in individuals with stroke, according to the NANDA-I Taxonomy. METHODS: Concept analysis from online access of four databases using the descriptors: impotence; helplessness, learned; Stroke, depression in languages: Portuguese, English and Spanish. RESULTS: The critical attributes of the feeling of powerlessness are: fragility, helplessness, lack of control, and power to achieve the proposed results for recovery and adaptation...
October 2017: Investigación y Educación en Enfermería
https://www.readbyqxmd.com/read/29760657/purkinje-cell-signaling-deficits-in-animal-models-of-ataxia
#18
REVIEW
Eriola Hoxha, Ilaria Balbo, Maria Concetta Miniaci, Filippo Tempia
Purkinje cell (PC) dysfunction or degeneration is the most frequent finding in animal models with ataxic symptoms. Mutations affecting intrinsic membrane properties can lead to ataxia by altering the firing rate of PCs or their firing pattern. However, the relationship between specific firing alterations and motor symptoms is not yet clear, and in some cases PC dysfunction precedes the onset of ataxic signs. Moreover, a great variety of ionic and synaptic mechanisms can affect PC signaling, resulting in different features of motor dysfunction...
2018: Frontiers in Synaptic Neuroscience
https://www.readbyqxmd.com/read/29752810/a-prospective-study-of-female-genital-chronic-graft-versus-host-disease-symptoms-signs-diagnosis-and-treatment
#19
Eva Smith Knutsson, Yvonne Björk, Anna-Karin Broman, Lotti Helström, Malin Nicklasson, Mats Brune, Karin Sundfeldt
INTRODUCTION: Female genital chronic graft-versus-host disease (cGvHD) is a complication of allogeneic hematopoietic cell transplantation (alloHCT) for blood malignancies. Unattended inflammation and fibrosis in the vulva and vagina may lead to total vaginal stenosis. The course and treatment of genital cGvHD was observed in this population-based prospective study. MATERIAL AND METHODS: Women (n = 41) receiving alloHCT in 2005-2010 were examined before and at 3, 6, 9, 12, 18, 24, 30, and 36 months post-transplant...
May 12, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29745889/potentially-traumatic-events-ptsd-and-post-traumatic-stress-spectrum-in-patients-with-fibromyalgia
#20
Ciro Conversano, Claudia Carmassi, Carlo A Bertelloni, Laura Marchi, Tommaso Micheloni, Manuel G Carbone, Giovanni Pagni, Claudia Tagliarini, Gabriele Massimetti, Laura M Bazzichi, Liliana Dell'Osso
OBJECTIVES: Fibromyalgia (FM) is defined as a severe, chronic, non-articular rheumatic condition characterised by widespread musculoskeletal pain, hyperalgesia and generalised tender points, in the absence of inflammatory or structural musculoskeletal abnormalities. Pain is the predominant symptom, allodynia and hyperalgesia are common signs. Extreme fatigue, impaired cognition and non-restorative sleeping difficulties coexist in addition to other somatic symptoms. Several studies suggest there is a meaningful relationship between FM and the psychological symptoms of depression and post-traumatic stress disorder (PTSD)...
April 24, 2018: Clinical and Experimental Rheumatology
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