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https://www.readbyqxmd.com/read/28335648/inflammation-and-pharmacokinetics-potential-implications-for-hiv-infection
#1
Sharon M Seifert, Jose R Castillo-Mancilla, Kristine M Erlandson, Peter L Anderson
The physiological changes accompanying inflammation may alter the pharmacokinetics (PK) of certain medications. Individuals infected with HIV have chronically elevated inflammatory markers despite viral suppression following effective antiretroviral therapy (ART), as well as age-related inflammation. Understanding the potential clinical implications of inflammation on the PK of medications is important for understanding dose-response relationships and necessitates future research. Areas covered: An extensive literature search was carried out using PubMed and associated bibliographies to summarize the current state of knowledge regarding altered PK in response to inflammation and its application to the field of HIV...
March 24, 2017: Expert Opinion on Drug Metabolism & Toxicology
https://www.readbyqxmd.com/read/28327885/prison-nursing-legal-framework-and-care-reality
#2
H Carrasco-Baún
INTRODUCTION: Penitentiary Nursing has experienced during the last decades a deep transformation similar to that experienced by the rest of the Nursing. However, there is a great distance from the protective legislation. OBJECTIVE: To analyze the main legal documents which regulate the functions of Penitentiary Nursing and to compare it with the health care reality of nurses in Spanish prisons. METHODOLOGY: Narrative bibliographic review based on various sources such as Medline, Cuiden, Scielo, Dialnet, etc...
June 2017: Revista Española de Sanidad Penitenciaria
https://www.readbyqxmd.com/read/28327572/the-role-of-genetic-counsellors-in-genomic-healthcare-in-the-united-kingdom-a-statement-by-the-association-of-genetic-nurses-and-counsellors
#3
Anna Middleton, Peter Marks, Anita Bruce, Liwsi K Protheroe-Davies, Cath King, Oonagh Claber, Catherine Houghton, Claire Giffney, Rhona Macleod, Claire Dolling, Sue Kenwrick, Diana Scotcher, Georgina Hall, Christine Patch, Laura Boyes
In the United Kingdom, genetic counsellors work together with clinical geneticists and clinical scientist colleagues within specialist genetics services, but they also often work in multidisciplinary teams (MDTs) outside of such services. There, they contribute genetic knowledge together with expert understanding of how to communicate genetic information effectively. They can offer education and support to the MDT, while providing management advice for both affected patients and the extended at-risk family members...
March 22, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28327143/the-imperative-for-systems-thinking-to-promote-access-to-medicines-efficient-delivery-and-cost-effectiveness-when-implementing-health-financing-reforms-a-qualitative-study
#4
Tom Achoki, Abaleng Lesego
BACKGROUND: Health systems across Africa are faced with a multitude of competing priorities amidst pressing resource constraints. Expansion of health insurance coverage offers promise in the quest for sustainable healthcare financing for many of the health systems in the region. However, the broader policy implications of expanding health insurance coverage have not been fully investigated and contextualized to many African health systems. METHODS: We interviewed 37 key informants drawn from public, private and civil society organizations involved in health service delivery in Botswana...
March 21, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28326926/potential-protein-biomarkers-for-burning-mouth-syndrome-discovered-by-quantitative-proteomics
#5
Eoon Hye Ji, Cynthia Diep, Tong Liu, Hong Li, Robert Merrill, Diana Messadi, Shen Hu
Burning mouth syndrome (BMS) is a chronic pain disorder characterized by severe burning sensation in normal looking oral mucosa. Diagnosis of BMS remains to be a challenge to oral healthcare professionals because the method for definite diagnosis is still uncertain. In this study, a quantitative saliva proteomic analysis was performed in order to identify target proteins in BMS patients' saliva that may be used as biomarkers for simple, non-invasive detection of the disease. By using isobaric tags for relative and absolute quantitation labeling and liquid chromatography-tandem mass spectrometry to quantify 1130 saliva proteins between BMS patients and healthy control subjects, we found that 50 proteins were significantly changed in the BMS patients when compared to the healthy control subjects ( p ≤ 0...
January 2017: Molecular Pain
https://www.readbyqxmd.com/read/28301356/local-heating-test-for-detection-of-microcirculation-abnormalities-in-patients-with-diabetes-related-foot-complications
#6
Aleksey Parshakov, Nadezhda Zubareva, Sergey Podtaev, Peter Frick
OBJECTIVE: In this study, authors used a wavelet analysis of skin temperature (WAST) to assess the mechanisms of microvascular tone regulation during the local heating test in patients with diabetic foot syndrome (DFS). PARTICIPANTS: The participants included control subjects and 36 hospitalized patients with DFS between 52 and 79 years old (68 ± 8 years old). They were distributed among 5 groups: 15 control subjects, 8 patients with DFS who did not develop ulcerative or necrotic disorders, 10 patients who developed the neuroischemic form of DFS complicated by foot ulceration, 12 patients with DFS complicated by toe necrosis, and 6 patients with DFS and foot gangrene...
April 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28300979/-family-healthcare-units-in-portugal-and-family-clinics-in-rio-de-janeiro-their-essence-and-similarities
#7
Eunice Isabel do Nacimento Carrapiço, João Henrique Vaz Ramires, Victor Manuel Borges Ramos
The authors address parallel developments in Family Healthcare Units (USF) in Portugal (since 2006) and in primary care Family Clinics (CF) in Rio de Janeiro (since 2009). In this essay, they highlight the meeting that took place in Portugal with Brazilian Health Ministry and Rio de Janeiro Department of Health members in October 2009. Being directly involved (since May 2016) in the development of USF in the Lisbon Region, and having visited, in November 2016, several CF in Rio de Janeiro, they analyze aspects such as: organization in permanent structural multi-professional teams; main common characteristics of the teams; teambuilding processes; organization and technical autonomy; instruments to regulate autonomy; responsibility and accountability - contracting processes; monitoring and evaluation; leadership system; motivational factors for professionals and for the team as a whole; learning organizations...
March 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28299786/changing-nurse-licensing-examinations-media-analysis-and-implications-of-the-canadian-experience
#8
L McGillis Hall, M Lalonde, J Kashin, C Yoo, J Moran
AIM: This study examines perceptions of the implementation of National Council Licensing Examination in Canada through a content analysis of articles in the media. BACKGROUND: Public opinions of nursing in the media have been acknowledged as important for the profession, specifically in relation to their portrayal of nursing. INTRODUCTION: The Canadian Council of Registered Nurse Regulators began using the US-based National Council Licensing Examination as entry examination (also known widely as NCLEX) for Canada's registered nurses, discontinuing the previous Canadian Registered Nurse Examination in 2015...
March 15, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28299610/pharmacovigilance-of-regenerative-medicine-under-the-amended-pharmaceutical-affairs-act-in-japan
#9
Yasuko Inokuma
Two Japanese regulatory agencies, the Ministry of Health, Labour and Welfare and the Pharmaceuticals and Medical Devices Agency announced the implementation of a new review system called 'Conditional Approval,' specifically for the emerging field of regenerative medicine, in an amendment to the Pharmaceutical Affairs Act in 2014. Regenerative medicine was regulated in the category of 'Medical Devices' prior to the amendment and was not covered by the Relief Service, a system that provides financial aid to people who have experienced an adverse drug reaction and developed serious side effects as a result...
March 15, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28293955/low-resistance-dual-purpose-air-filter-releasing-negative-ions-and-effectively-capturing-pm2-5
#10
Xinglei Zhao, Yuyao Li, Ting Hua, Pan Jiang, Xia Yin, Jianyong Yu, Bin Ding
The fatal danger of pollution due to particulate matter (PM) calls for both high-efficiency and low-resistance air purification materials, which also provide healthcare. This is however still a challenge. Herein, a low-resistance air filter capable of releasing negative ions (NIs) and efficiently capturing PM2.5 was prepared by electrospinning polyvinylidene fluoride (PVDF) fibers doped with negative ions powder (NIPs). The air-resistance of fibrous membranes decreased from 9.5 to 6 Pa (decrease of 36%) on decreasing the average fiber diameter from 1...
March 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28291156/experience-of-home-telehealth-technology-in-older-patients-with-diabetes
#11
Chi-Ping Chang, Ting-Ting Lee, Mary Etta Mills
The incidence of diabetes, a common chronic disease among older adults, is increasing annually. The lack of blood glucose regulation can result in severe diabetes-related complications and substantial healthcare costs, making self-care programs specific to this population especially important. Combined with reduced numbers of healthcare professionals, the integration of healthcare and information technology and the older adults' adoption of telehealth services have become increasingly important. This study used a qualitative method to interview 18 older study participants who used a telehealth service...
March 14, 2017: Computers, Informatics, Nursing: CIN
https://www.readbyqxmd.com/read/28283307/obstetric-fistula-and-sociocultural-practices-in-hausa-community-of-northern-nigeria
#12
Oluwakemi C Amodu, Bukola Salami, Solina Richter
BACKGROUND: Obstetric Fistula is a childbirth injury that disproportionately affects women in sub-Saharan Africa. Although poverty plays an important role in perpetuating obstetric fistula, sociocultural practices has a significant influence on susceptibility to the condition. AIM: This paper aims to explore narratives in the literature on obstetric fistula in the context of Hausa ethno-lingual community of Northern Nigeria and the potential role of nurses and midwives in addressing obstetric fistula...
March 7, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28283046/recommendations-from-the-european-working-group-for-value-assessment-and-funding-processes-in-rare-diseases-orph-val
#13
Lieven Annemans, Ségolène Aymé, Yann Le Cam, Karen Facey, Penilla Gunther, Elena Nicod, Michele Reni, Jean-Louis Roux, Michael Schlander, David Taylor, Carlo Tomino, Josep Torrent-Farnell, Sheela Upadhyaya, Adam Hutchings, Lugdivine Le Dez
Rare diseases are an important public health issue with high unmet need. The introduction of the EU Regulation on orphan medicinal products (OMP) has been successful in stimulating investment in the research and development of OMPs. Despite this advancement, patients do not have universal access to these new medicines. There are many factors that affect OMP uptake, but one of the most important is the difficulty of making pricing and reimbursement (P&R) decisions in rare diseases. Until now, there has been little consensus on the most appropriate assessment criteria, perspective or appraisal process...
March 10, 2017: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/28282721/ethical-issues-surrounding-personalized-medicine-a-literature-review
#14
Pooneh Salari, Bagher Larijani
More than a decade ago, personalized medicine was presented in modern medicine. Personalized medicine means that the right drug should be prescribed for the right patient based on genetic data. No doubt is developing medical sciences, and its shift into personalized medicine complicates ethical challenges more than before. In this review, we categorized all probable ethical considerations of personalized medicine in research and development and service provision. Based on our review, extensive changes in healthcare system including ethical changes are needed to overcome the ethical obstacles including knowledge gap and informed consent, privacy and confidentiality and availability of healthcare services...
March 2017: Acta Medica Iranica
https://www.readbyqxmd.com/read/28282361/use-of-analgesics-in-young-adults-as-a-predictor-of-health-care-utilization-and-pain-prevalence-israel-defense-forces-experience
#15
Karina Dorfman, Olga Komargodski, Racheli Magnezi, Stanislav Lifshitz, Dorit Tzur, Nirit Yavnai, Gal Ifergane
Pain evaluation in large community studies is difficult. Analgesics can be a useful tool in estimating pain related conditions in which analgesic use is highly regulated. In this study we evaluated analgesics consumption patterns of regular Israel Defense Force soldiers. We have performed a historical cohort study of 665,137 young adults during active duty in 2002-2012. Analgesics were prescribed to 518,242 (78%) soldiers, mostly for musculoskeletal pain (69.3%), abdominal pain (12.7%) and headache (12.1%)...
March 7, 2017: Pain
https://www.readbyqxmd.com/read/28276942/probiotic-use-in-an-infectious-disease-setting
#16
Gregor Reid
The lethality of infectious diseases and deep concern over growing antimicrobial resistance make it essential that alternative or adjunct therapies be developed. Areas covered: Using papers published in PubMed, a case is presented to consider beneficial microbes as a means to improve management of infectious diseases. Clinical evidence is mounting that certain probiotic microbes can contribute to this armamentarium. These could have an immediate effect against necrotizing enterocolitis, pre- and post-surgical procedures, antibiotic-associated infections, urogenital infections in women and for reducing the severity and duration of respiratory infections...
March 1, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/28276541/modulation-of-the-mechanical-properties-of-bacterial-biofilms-in-response-to-environmental-challenges
#17
REVIEW
Marwa Tallawi, Madeleine Opitz, Oliver Lieleg
Bacterial communities form biofilms on a wide range of surfaces by synthesizing a cohesive and protective extracellular matrix. The morphology, internal structure and mechanical stability of a biofilm are largely determined by its constituent polymers. In addition to mediating adhesion to surfaces, biofilms control the uptake of molecules and regulate the permeability of the matrix to gases and chemicals. Since biofilms can cause significant problems in both industrial and healthcare settings, there is great interest in developing strategies that either inhibit their formation or facilitate their elimination...
March 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28276135/-seeking-authorization-a-grounded-theory-exploration-of-mentors-experiences-of-assessing-nursing-students-on-the-borderline-of-achievement-of-competence-in-clinical-practice
#18
Simon Cassidy, Michael Coffey, Fiona Murphy
AIM: To develop a substantive theoretical explanation of how mentors make sense of their experiences where nursing students are on the borderline of achievement of competence in clinical practice. BACKGROUND: The reluctance of registered nurse mentors to fail nursing students in clinical practice despite concerns about competence remains a contemporary issue in international healthcare education. Mentors' assessment decisions have considerable impact for a variety of key stakeholders, not least for students in these circumstances...
March 9, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28271773/nmc-is-well-equipped-to-regulate-the-new-nursing-associate-role
#19
Dame Janet Finch
One of the big things on the Nursing and Midwifery Council's (NMC) 2017 agenda is nursing associates, the new role bridging the gap between healthcare assistants and nurses.
March 8, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28269236/status-and-solutions-to-medical-device-regulations-for-improving-the-healthcare-landscape-in-africa
#20
A Lissel, F Ottenberg, B R Bracio, A Ravizza, C De Maria, A Ahluwalia, L Di Pietro, P Trommler
For different reasons most African countries have a poor public healthcare system compared to developed countries. Despite an increasing number of patients they often lack skilled health workers as well as basic medical equipment. This paper focuses on the development of an affordable and sustainable system for medical device regulations to provide safe, effective and quality healthcare products for Africa. Furthermore, it is determined whether Open Source Medical Devices are an effective alternative for medical device regulations to increase innovations in Africa...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
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