keyword
MENU ▼
Read by QxMD icon Read
search

Bacterial adaptive immunity

keyword
https://www.readbyqxmd.com/read/28329174/ccr7-deficiency-modulates-t-cell-response-and-increases-susceptibility-to-yersinia-pseudotuberculosis-infection
#1
Joern Pezoldt, Fabio Pisano, Wiebke Heine, Maria Pasztoi, Maik Rosenheinrich, Aaron M Nuss, Marina C Pils, Immo Prinz, Reinhold Förster, Jochen Huehn, Petra Dersch
Background: To successfully limit pathogen dissemination an immunological link between the entry tissue of the pathogen and the underlying secondary lymphoid organs (SLO) needs to be established to prime adaptive immune responses. Here, the prerequisite of CCR7 to mount host immune responses within SLOs during gastrointestinal Yersinia pseudotuberculosis infection to limit pathogen spread was investigated. Methods: Survival, bacterial dissemination, intestinal and systemic pathology of wild type (WT) and CCR7-/- mice were assessed and correlated to the presence of immune cell subsets and cytokine responses throughout the course of infection...
January 27, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28328921/versatile-modes-of-cellular-regulation-via-cyclic-dinucleotides
#2
REVIEW
Petya Violinova Krasteva, Holger Sondermann
Since the discovery of c-di-GMP almost three decades ago, cyclic dinucleotides (CDNs) have emerged as widely used signaling molecules in most kingdoms of life. The family of second messengers now includes c-di-AMP and distinct versions of mixed cyclic GMP-AMP (cGAMP) compounds. In addition to these nucleotides, a vast number of proteins for the production and turnover of these molecules have been described, as well as effectors that translate the signals into physiological responses. The latter include, but are not limited to, mechanisms for adaptation and survival in prokaryotes, persistence and virulence of bacterial pathogens, and immune responses to viral and bacterial invasion in eukaryotes...
March 22, 2017: Nature Chemical Biology
https://www.readbyqxmd.com/read/28327797/bacterial-immunostat-mycobacterium-tuberculosis-lipids-and-their-role-in-the-host-immune-response
#3
Adriano Queiroz, Lee W Riley
The lipid-rich cell wall of Mycobacterium tuberculosis is a dynamic structure that is involved in the regulation of the transport of nutrients, toxic host-cell effector molecules, and anti-tuberculosis drugs. It is therefore postulated to contribute to the long-term bacterial survival in an infected human host. Accumulating evidence suggests that M. tuberculosis remodels the lipid composition of the cell wall as an adaptive mechanism against host-imposed stress. Some of these lipid species (trehalose dimycolate, diacylated sulphoglycolipid, and mannan-based lipoglycans) trigger an immunopathologic response, whereas others (phthiocerol dimycocerosate, mycolic acids, sulpholipid-1, and di-and polyacyltrehalose) appear to dampen the immune responses...
January 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/28326980/gene-sequence-analyses-of-the-healthy-oral-microbiome-in-humans-and-companion-animals
#4
Eric M Davis
It has long been accepted that certain oral bacterial species are responsible for the development of periodontal disease. However, the focus of microbial and immunological research is shifting from studying the organisms associated with disease to examining the indigenous microbial inhabitants that are present in health. Microbiome refers to the aggregate genetic material of all microorganisms living in, or on, a defined habitat. Recent developments in gene sequence analysis have enabled detection and identification of bacteria from polymicrobial samples, including subgingival plaque...
June 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28325762/a-genetic-screen-reveals-that-synthesis-of-1-4-dihydroxy-2-naphthoate-dhna-but-not-full-length-menaquinone-is-required-for-listeria-monocytogenes-cytosolic-survival
#5
Grischa Y Chen, Courtney E McDougal, Marc A D'Antonio, Jonathan L Portman, John-Demian Sauer
Through unknown mechanisms, the host cytosol restricts bacterial colonization; therefore, only professional cytosolic pathogens are adapted to colonize this host environment. Listeria monocytogenes is a Gram-positive intracellular pathogen that is highly adapted to colonize the cytosol of both phagocytic and nonphagocytic cells. To identify L. monocytogenes determinants of cytosolic survival, we designed and executed a novel screen to isolate L. monocytogenes mutants with cytosolic survival defects. Multiple mutants identified in the screen were defective for synthesis of menaquinone (MK), an essential molecule in the electron transport chain...
March 21, 2017: MBio
https://www.readbyqxmd.com/read/28320836/adaptive-upregulation-of-clumping-factor-a-clfa-by-s-aureus-in-the-obese-type-2-diabetic-host-mediates-increased-virulence
#6
Christopher W Farnsworth, Eric M Schott, Sarah E Jensen, Jacob Zukoski, Abigail M Benvie, Majed A Refaai, Stephen L Kates, Edward M Schwarz, Michael J Zuscik, Steven R Gill, Robert A Mooney
Obesity and associated type 2 diabetes (T2D) are important risk factors for infection following orthopaedic implant surgery. Staphylococcus aureus, the most common pathogen in bone infections, adapts to multiple environments to survive and evade host immune responses. Whether adaptation of S. aureus to the unique environment of the obese/T2D host accounts for its increased virulence and persistence in this population is unknown. Thus, we assessed implant-associated osteomyelitis in normal versus high fat-diet obese/T2D mice and found that S...
March 20, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28293548/age-appropriate-functions-and-dysfunctions-of-the-neonatal-neutrophil
#7
REVIEW
Shelley Melissa Lawrence, Ross Corriden, Victor Nizet
Neonatal and adult neutrophils are distinctly different from one another due to well-defined and documented deficiencies in neonatal cells, including impaired functions, reduced concentrations of microbicidal proteins and enzymes necessary for pathogen destruction, and variances in cell surface receptors. Neutrophil maturation is clearly demonstrated throughout pregnancy from the earliest hematopoietic precursors in the yolk sac to the well-developed myeloid progenitor cells in the bone marrow around the seventh month of gestation...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28293236/interferon-lambda-modulating-immunity-in-infectious-diseases
#8
REVIEW
Mohammedyaseen Syedbasha, Adrian Egli
Interferon lambdas (IFN-λs; IFNL1-4) modulate immunity in the context of infections and autoimmune diseases, through a network of induced genes. IFN-λs act by binding to the heterodimeric IFN-λ receptor (IFNLR), activating a STAT phosphorylation-dependent signaling cascade. Thereby hundreds of IFN-stimulated genes are induced, which modulate various immune functions via complex forward and feedback loops. When compared to the well-characterized IFN-α signaling cascade, three important differences have been discovered...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28292985/binding-of-candida-albicans-to-human-ceacam1-and-ceacam6-modulates-the-inflammatory-response-of-intestinal-epithelial-cells
#9
Esther Klaile, Mario M Müller, Miriam R Schäfer, Ann-Katrin Clauder, Sabina Feer, Kerstin A Heyl, Magdalena Stock, Tilman E Klassert, Peter F Zipfel, Bernhard B Singer, Hortense Slevogt
Candida albicans colonizes human mucosa, including the gastrointestinal tract, as a commensal. In immunocompromised patients, C. albicans can breach the intestinal epithelial barrier and cause fatal invasive infections. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1; CD66a), CEACAM5 (CEA), and CEACAM6 (CD66c) are immunomodulatory receptors expressed on human mucosa and are recruited by bacterial and viral pathogens. Here we show for the first time that a fungal pathogen (i.e., C. albicans) also binds directly to the extracellular domain of human CEACAM1, CEACAM3, CEACAM5, and CEACAM6...
March 14, 2017: MBio
https://www.readbyqxmd.com/read/28287876/crispr-cas9-from-a-bacterial-immune-system-to-genome-edited-human-cells-in-clinical-trials
#10
Leonhard Kick, Marion Kirchner, Sabine Schneider
The adaptive bacterial immune system CRISPR-Cas is revolutionising all fields of life science and has opened up new frontiers towards personalised medicine. Since the elucidation of the molecular mechanism of Cas9 from Streptococcus pyogenes in 2012 and its development as a genomic engineering tool, genetic modifications in more than 40 species have been carried out, over 290 patents have been filed worldwide and the first clinical trials using CRISPR-Cas-modified T-cells have recently been started in China and in the US...
March 13, 2017: Bioengineered
https://www.readbyqxmd.com/read/28284621/identification-of-a-novel-host-specific-igg-protease-in-streptococcus-phocae-subsp-phocae
#11
Viktoria Rungelrath, Jan Christian Wohlsein, Ursula Siebert, Jeffrey Stott, Ellen Prenger-Berninghoff, Ulrich von Pawel-Rammingen, Peter Valentin-Weigand, Christoph G Baums, Jana Seele
Streptococcus (S.) phocae subsp. phocae causes bronchopneumonia and septicemia in a variety of marine mammals. Especially in harbor seals infected with phocine distemper virus it plays an important role as an opportunistic pathogen. This study was initiated by the detection of IgG cleavage products in Western blot analysis after incubation of bacterial supernatant with harbor seal serum. Hence, the objectives of this study were the identification and characterization of a secreted IgG cleaving protease in S...
March 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28283475/rhinovirus-bacteria-co-exposure-synergistically-induces-ccl20-production-from-human-bronchial-epithelial-cells
#12
Barbara A Maciejewski, Kyla C Jamieson, Jason W Arnason, Cora Kooi, Shahina Wiehler, Suzanne L Traves, Richard Leigh, David Proud
Exacerbations of chronic obstructive pulmonary disease (COPD) are triggered by viral or bacterial pathogens, with human rhinovirus (HRV) and nontypeable Haemophilus influenzae (NTHI) among the most commonly detected pathogens. Patients who suffer from concomitant viral and bacterial infection have more severe exacerbations. The airway epithelial cell is the initial site of viral and bacterial interactions, and CCL20 is an epithelial chemokine that attracts immature dendritic cells to the airways, and can act as an antimicrobial...
March 10, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28283194/cell-responses-to-cariogenic-microorganisms-and-dental-resin-materials-crosstalk-at-the-dentin-pulp-interface
#13
REVIEW
Helmut Schweikl, Wolfgang Buchalla, Stephanie Krifka
OBJECTIVE: Resin monomers released from unpolymerized dental adhesives or composites and bacterial products like lipopolysaccharide (LPS) or lipoteichoic (LTA) are simultaneously present in specific applications following treatment of deep caries lesions. This review is focused on evidence concerning cell responses as a result of the interactions between adaptive mechanisms activated by resin monomers and signaling pathways of the immune response triggered by LPS or LTA originating from cariogenic microorganisms...
March 7, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28266511/immunity-to-uropathogens-the-emerging-roles-of-inflammasomes
#14
REVIEW
Claire Hamilton, Lionel Tan, Thomas Miethke, Paras K Anand
Urinary tract infections (UTIs) cause a huge burden of morbidity worldwide with recurrent UTIs becoming increasingly frequent owing to the emergence of antibiotic-resistant bacterial strains. Interactions between the innate and adaptive immune responses to pathogens colonizing the urinary tract have been the focus of much research. Inflammasomes are part of the innate immune defence and can respond rapidly to infectious insult. Assembly of the multiprotein inflammasome complex activates caspase-1, processes proinflammatory cytokines IL-1β and IL-18, and induces pyroptosis...
March 7, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28265270/borrelia-burgdorferi-manipulates-innate-and-adaptive-immunity-to-establish-persistence-in-rodent-reservoir-hosts
#15
REVIEW
Karen E Tracy, Nicole Baumgarth
Borrelia burgdorferi sensu lato species complex is capable of establishing persistent infections in a wide variety of species, particularly rodents. Infection is asymptomatic or mild in most reservoir host species, indicating successful co-evolution of the pathogen with its natural hosts. However, infected humans and other incidental hosts can develop Lyme disease, a serious inflammatory syndrome characterized by tissue inflammation of joints, heart, muscles, skin, and CNS. Although B. burgdorferi infection induces both innate and adaptive immune responses, they are ultimately ineffective in clearing the infection from reservoir hosts, leading to bacterial persistence...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28264991/giga-and-gigb-are-master-regulators-of-antibiotic-resistance-stress-responses-and-virulence-in-acinetobacter-baumannii
#16
Michael J Gebhardt, Howard A Shuman
A critical component of bacterial pathogenesis is the ability of an invading organism to sense and adapt to the harsh environment imposed by the host's immune system. This is especially important for opportunistic pathogens, such as Acinetobacter baumannii, a nutritionally versatile, environmental organism that has recently gained attention as a life-threatening human pathogen. The emergence of A. baumannii is closely linked to antibiotic resistance and many contemporary isolates are multi-drug resistant (MDR)...
March 6, 2017: Journal of Bacteriology
https://www.readbyqxmd.com/read/28263305/cyclic-di-gmp-regulates-lipopolysaccharide-modification-and-contributes-to-pseudomonas-aeruginosa-immune-evasion
#17
Ronan R McCarthy, Maria J Mazon-Moya, Joana A Moscoso, Youai Hao, Joseph S Lam, Christophe Bordi, Serge Mostowy, Alain Filloux
Pseudomonas aeruginosa is a Gram-negative bacterial pathogen associated with acute and chronic infections. The universal cyclic-di-GMP second messenger is instrumental in the switch from a motile lifestyle to resilient biofilm as in the cystic fibrosis lung. The SadC diguanylate cyclase is associated with this patho-adaptive transition. Here, we identify an unrecognized SadC partner, WarA, which we show is a methyltransferase in complex with a putative kinase, WarB. We established that WarA binds to cyclic-di-GMP, which potentiates its methyltransferase activity...
March 6, 2017: Nature Microbiology
https://www.readbyqxmd.com/read/28261452/bigger-is-better-changes-in-body-size-explain-a-maternal-effect-of-food-on-offspring-disease-resistance
#18
Jennie S Garbutt, Tom J Little
Maternal effects triggered by changes in the environment (e.g., nutrition or crowding) can influence the outcome of offspring-parasite interactions, with fitness consequences for the host and parasite. Outside of the classic example of antibody transfer in vertebrates, proximate mechanisms have been little studied, and thus, the adaptive significance of maternal effects on infection is not well resolved. We sought to determine why food-stressed mothers give birth to offspring that show a low rate of infection when the crustacean Daphnia magna is exposed to an orally infective bacterial pathogen...
March 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28257033/lactoferrin-balancing-ups-and-downs-of-inflammation-due-to-microbial-infections
#19
REVIEW
Maria Elisa Drago-Serrano, Rafael Campos-Rodríguez, Julio César Carrero, Mireya de la Garza
Lactoferrin (Lf) is a glycoprotein of the primary innate immune-defense system of mammals present in milk and other mucosal secretions. This protein of the transferrin family has broad antimicrobial properties by depriving pathogens from iron, or disrupting their plasma membranes through its highly cationic charge. Noteworthy, Lf also exhibits immunomodulatory activities performing up- and down-regulation of innate and adaptive immune cells, contributing to the homeostasis in mucosal surfaces exposed to myriad of microbial agents, such as the gastrointestinal and respiratory tracts...
March 1, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28255719/a-protein-expression-toolkit-for-studying-signaling-in-t-cells
#20
Ana Mafalda Santos, Jiandong Huo, Deborah Hatherley, Mami Chirifu, Simon J Davis
Innate and adaptive cellular immunity is dependent on interactions of cell surface receptors that initiate signaling, resulting in the formation of the immunological synapse and targeted delivery of effector functions. There has been considerable interest over the past 30 years in methods for isolating the extracellular regions of these receptors and components of the cytoplasmic signaling networks. This chapter describes our current protein expression toolkit used for structural studies of signaling proteins and the functional reconstitution of model cell surfaces, which comprises both bacterial and mammalian cell-based protein expression methodologies...
2017: Methods in Molecular Biology
keyword
keyword
84076
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"