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theanine, bdnf

Hui Shen, Xinnan Shen, Ruozhong Wang, Min Wu
OBJECTIVE: To study the protective effect of theanine on cerebral ischemia-reperfusion injury induced by focal cerebral ischemia in rats. METHOD: Sprague-Dawley rats were randomly assigned into five groups: model group, shame (SH) control group and 3 theanine groups (Th-L,Th-M and Th-H). The rats in model and SH groups were given distilled water, and the rats in Th groups were given theanine solution (10, 30 and 90 mg/kg respectively) intragastrically for 15 days...
November 2011: Wei Sheng Yan Jiu, Journal of Hygiene Research
Chisato Wakabayashi, Tadahiro Numakawa, Midori Ninomiya, Shuichi Chiba, Hiroshi Kunugi
RATIONALE: L-Theanine (N-ethyl-L: -glutamine) is an amino acid uniquely found in green tea and historically considered to be a relaxing agent. It is a glutamate derivative and has an affinity for glutamatergic receptors. However, its psychotropic effects remain unclear. OBJECTIVES: To elucidate effects of L: -theanine on psychiatric disease-related behaviors in mice and its molecular basis focusing on brain-derived neurotrophic factor (BDNF) and N-methyl-D: -aspartate (NMDA) receptor...
February 2012: Psychopharmacology
Chanoch Miodownik, Rachel Maayan, Yael Ratner, Vladimir Lerner, Leonid Pintov, Maria Mar, Abraham Weizman, Michael S Ritsner
OBJECTIVES: L-Theanine (γ-glutamylethylamide) augmentation to antipsychotic therapy ameliorates positive, activation, and anxiety symptoms in schizophrenia and schizoaffective disorder patients. This study examines the association between circulating levels of neurochemical indicators and the beneficial clinical effects of L-theanine augmentation. METHODS: Serum levels of neurochemical indicators such as brain-derived neurotrophic factor (BDNF), dehydroepiandrosterone (DHEA), its sulfate (DHEAS), cortisol, cholesterol, and insulin were monitored in 40 schizophrenia and schizoaffective disorder patients during an 8-week, double-blind, randomized, placebo-controlled trial with L-theanine (400 mg/d)...
July 2011: Clinical Neuropharmacology
Atsushi Takeda, Kazuhiro Sakamoto, Haruna Tamano, Kotaro Fukura, Naoto Inui, Sang Won Suh, Seok-Joon Won, Hidehiko Yokogoshi
Theanine, γ-glutamylethylamide, is one of the major amino acid components in green tea. In this study, cognitive function and the related mechanism were examined in theanine-administered young rats. Newborn rats were fed theanine through dams, which were fed water containing 0.3% theanine, and then fed water containing 0.3% theanine after weaning. Theanine level in the brain was under the detectable limit 6 weeks after the start of theanine administration. Theanine administration did not influence locomotor activity in the open-field test...
October 2011: Cellular and Molecular Neurobiology
Hong-Suk Cho, Seung Kim, Sook-Young Lee, Jeong Ae Park, Sung-Jun Kim, Hong Sung Chun
Several environmental neurotoxins and oxidative stress inducers are known to damage the nervous system and are considered major factors associated with the selective vulnerability of nigral dopaminergic neurons in Parkinson's disease (PD). Gamma-glutamylethylamide (L-theanine), a natural glutamate analog in green tea, has been shown to exert strong anti-ischemic effect. In this study, we investigated the protective effects of L-theanine on neurotoxicity induced by PD-related neurotoxicants, rotenone and dieldrin in cultured human dopaminergic cell line, SH-SY5Y...
July 2008: Neurotoxicology
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