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https://www.readbyqxmd.com/read/27924713/acetylcholinesterase-and-neuropathy-target-esterase-activities-in-11-cases-of-symptomatic-flight-crew-members-after-fume-events
#1
Astrid R R Heutelbeck, Catherine Bornemann, Martina Lange, Anke Seeckts, Michael M Müller
In modern aviation, so-called fume events such as exposure to an unknown mixture of chemicals introduced into the aircraft cabin with bleed air drawn off at the engines may occur. Human exposure may result in (neuro)toxic symptoms described as so-called "aerotoxic syndrome." Currently, among other agents organophosphates (OP) are regarded as a likely cause of the observed adverse effects. After fume events 11 flight crew members (9 female/2 male; ages 23-58 yr) were admitted for a medical examination within 5 d post exposure...
2016: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/27923928/visual-sampling-predicts-hippocampal-activity
#2
Zhong-Xu Liu, Kelly Shen, Rosanna K Olsen, Jennifer D Ryan
: Eye movements serve to accumulate information from the visual world, contributing to the formation of coherent memory representations that support cognition and behaviour. The hippocampus and the oculomotor network are well connected anatomically through an extensive set of polysynaptic pathways. However, the extent to which visual sampling behaviour is related to functional responses in the hippocampus during encoding has not been directly studied in human neuroimaging. In the current study, participants engaged in a face processing task while brain responses were recorded with functional magnetic resonance imaging (fMRI) and eye movements were simultaneously monitored...
December 6, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27923524/the-therapeutic-potential-of-metabolic-hormones-in-the-treatment-of-age-related-cognitive-decline-and-alzheimer-disease
#3
REVIEW
John Grizzanti, Hyoung-Gon Lee, Antoni Camins, Merce Pallas, Gemma Casadesus
Aging leads to a number of physiological alterations, specifically changes in circulating hormone levels, increases in fat deposition, decreases in metabolism, changes in inflammatory responses, and reductions in growth factors. These progressive changes in physiology and metabolism are exacerbated by modern culture and Western diet and give rise to diseases such as obesity, metabolic syndrome, and type 2 (non-insulin-dependent) diabetes (T2D). These age and lifestyle-related metabolic diseases are often accompanied by insulin and leptin resistance, as well as aberrant amylin production and signaling...
November 8, 2016: Nutrition Research
https://www.readbyqxmd.com/read/27923162/comparison-of-different-osmotic-therapies-in-a-mouse-model-of-traumatic-brain-injury
#4
Vinoth K M Khandelwal, Prabhakar Singh, Tatiana Ravingerova, Marslin Gregory, Hardik Gandhi, Manu Chaudhary
BACKGROUND: Inflammation in the affected region, increased intracranial pressure, consequent oedema and congestion contribute to the negative outcome of traumatic brain injury. Osmotic therapies are recommended for improvement in cognitive and motor functions. Aim of the present study was to evaluate the effect of osmotic therapies in a mice model of traumatic brain injury. METHODS: Experimental closed head injury was performed in adult Swiss albino mice by the weight-drop method...
October 11, 2016: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/27922701/elolyckor-kan-ge-skador-som-visar-sig-efter-l%C3%A3-ng-tid-det-akuta-omh%C3%A3-ndertagandet-kan-vara-avg%C3%A3-rande-p%C3%A3-sikt
#5
Martin Tondel, Anna Blomqvist, Kristina Jakobsson, Tohr Nilsson, Bodil Persson, Sara Thomée, Lars-Gunnar Gunnarsson
Immediate and delayed outcomes after electrical injury. A guide for clinicians In Sweden about 300 electrical injuries are recorded each year at the Swedish National Electrical Safety Board. Most of our knowledge of the health consequences of these arise from clinical case series. Severe electrical injuries have direct thermal effects and may result in ventricular fibrillation, skin burns, as well as muscular and nerve affection. Long-term consequences include pain, vascular symptoms, cognitive and neurological symptoms and signs...
December 1, 2016: Läkartidningen
https://www.readbyqxmd.com/read/27922237/the-comparison-of-general-movements-assessment-and-neurological-examination-during-early-infancy
#6
Büşra Kepenek-Varol, Mine Çalışkan, Zeynep İnce, Burak Tatlı, Emine Eraslan, Asuman Çoban
This prospective single-blinded study was performed to evaluate general movements (GMs) in group of high-risk, low-birth-weight and preterm infants and to compare results with neurologic examination. All infants' neurologic examinations, Gross Motor Function Measurement (GMFM) and Bayley-III Scale were performed at the corrected age of 12 months. A total of 22 infants were included. Eight infants (group-1) (mean: 31.6±3.29 weeks, range: 25-36 weeks) had normal GMs in all recordings and were ultimately evaluated as "normal"; 12 (group-2) (mean: 31...
2016: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27922168/update-of-the-swiss-guidelines-on-post-treatment-lyme-disease-syndrome
#7
Johannes Nemeth, Enos Bernasconi, Ulrich Heininger, Mohamed Abbas, David Nadal, Carol Strahm, Stefan Erb, Stefan Zimmerli, Hansjakob Furrer, Julie Delaloye, Thierry Kuntzer, Ekkehard Altpeter, Mathias Sturzenegger, Rainer Weber, For The Swiss Society For Infectious Diseases And The Swiss Society For Neurology
Lyme borreliosis is caused by Borrelia burgdorferi sensu lato infection, which responds well to antibiotic therapy in the overwhelming majority of cases. However, despite adequate antibiotic treatment some patients report persisting symptoms which are commonly summarised as post-treatment Lyme disease syndrome (PTLDS). In 2005, the Swiss Society of Infectious Diseases published a case definition for PTLDS. We aimed to review the scientific literature with a special emphasis on the last 10 years, questioning whether the definitions from 2005 are still valid in the light of current knowledge...
2016: Swiss Medical Weekly
https://www.readbyqxmd.com/read/27921222/cognitive-dysfunction-in-patients-with-brain-metastases-influences-on-caregiver-resilience-and-coping
#8
Marlon Garzo Saria, Natasia Courchesne, Lorraine Evangelista, Joshua Carter, Daniel A MacManus, Mary Kay Gorman, Adeline M Nyamathi, Linda R Phillips, David Piccioni, Santosh Kesari, Sally Maliski
PURPOSE: Neurologic deficits that may be manifested as cognitive impairment contribute to the challenges faced by caregivers of patients with brain metastases. To better address their needs, we examined how caregivers respond to these challenges and explore the relationship between the patient's cognitive impairment and caregiver resilience and coping. METHODS: We conducted a descriptive, cross-sectional study using self-reported data from 56 caregivers of patients with brain metastases...
December 5, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27920793/cognitive-decline-in-patients-with-chronic-hydrocephalus-and-normal-aging-growing-into-deficits
#9
Marlijn H de Beer, Philip Scheltens
BACKGROUND/AIM: To explore the theory of 'growing into deficits', a concept known from developmental neurology, in a series of cases with chronic hydrocephalus (CH). METHODS: Patients were selected from the Amsterdam Dementia Cohort and underwent extensive dementia screening. RESULTS: Twelve patients with CH were selected, in whom Alzheimer's disease was considered unlikely, based on biomarker information and follow-up. Mean Mini-Mental State Examination score was 24 (range 7-30)...
September 2016: Dementia and Geriatric Cognitive Disorders Extra
https://www.readbyqxmd.com/read/27919696/the-role-of-anxiety-in-stuttering-evidence-from-functional-connectivity
#10
Yang Yang, Fanlu Jia, Wai Ting Siok, Li Hai Tan
Persistent developmental stuttering is a neurologically based speech disorder associated with cognitive-linguistic, motor and emotional abnormalities. Previous studies investigating the relationship between anxiety and stuttering have yielded mixed results, but it has not yet been examined whether anxiety influences brain activity underlying stuttering. Here, by using functional magnetic resonance imaging (fMRI), we investigated the functional connectivity associated with state anxiety in a syllable repetition task, and trait anxiety during rest in adults who stutter (N=19) and fluent controls (N=19)...
December 2, 2016: Neuroscience
https://www.readbyqxmd.com/read/27919694/neuron-specific-sumo-knockdown-suppresses-global-gene-expression-response-and-worsens-functional-outcome-after-transient-forebrain-ischemia-in-mice
#11
Lin Zhang, Xiaozhi Liu, Huaxin Sheng, Shuai Liu, Ying Li, Julia Q Zhao, David S Warner, Wulf Paschen, Wei Yang
Small ubiquitin-like modifier (SUMO) conjugation (SUMOylation) plays key roles in neurologic function in health and disease. Neuronal SUMOylation is essential for emotionality and cognition, and this pathway is dramatically activated in post-ischemic neurons, a neuroprotective response to ischemia. It is also known from cell culture studies that SUMOylation modulates gene expression. However, it remains unknown how SUMOylation regulates neuronal gene expression in vivo, in the physiologic state and after ischemia, and modulates post-ischemic recovery of neurologic function...
December 2, 2016: Neuroscience
https://www.readbyqxmd.com/read/27919483/a-systematic-review-of-anxiety-amongst-people-with-multiple-sclerosis
#12
REVIEW
Ellen Butler, Faith Matcham, Trudie Chalder
BACKGROUND: Multiple Sclerosis (MS) is a chronic neurological disease, which poses significant psychological challenges. The purpose of this systematic review was to identify factors that are associated with anxiety in people with MS (PwMS). It aimed to examine the strength of evidence for factors associated with anxiety symptoms and identify limitations of existing studies. METHOD AND RESULTS: One hundred and thirty one studies met inclusion criteria and were included in the review...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919474/a-study-of-cognitive-fatigue-in-multiple-sclerosis-with-novel-clinical-and-electrophysiological-parameters-utilizing-the-event-related-potential-p300
#13
Somasundaram Aadhimoolam Chinnadurai, Srinivasan Avathvadi Venkatesan, Gobinathan Shankar, Balasubramanian Samivel, Lakshmi Narasimhan Ranganathan
BACKGROUND: Although cognitive fatigue plays a significant part in Multiple Sclerosis (MS) related impairment, knowledge regarding it is largely lacking. Until now, not many tools are available to a clinician to detect cognitive fatigue. The subjective tools of fatigue have never been reliable.tabl OBJECTIVES: To assess the prevalence and clinical/ demographic profile of cognitive fatigue in MS using novel clinical and electrophysiological measures and to find their accuracy. We also aimed to test the three leading hypotheses - the temporal fatigue, cognitive load and cognitive domain hypotheses of cognitive fatigue in MS...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27918287/measuring-discrimination-and-reversal-learning-in-mouse-models-within-4-days-and-without-prior-food-deprivation
#14
Esther Remmelink, August B Smit, Matthijs Verhage, Maarten Loos
Many neurological and psychiatric disorders are characterized by deficits in cognitive flexibility. Modeling cognitive flexibility in mice enables the investigation of mechanisms underlying these deficits. The majority of currently available behavioral tests targeting this cognitive domain are reversal learning tasks that require scheduled food restriction, extended training periods and labor-intensive, and stress-inducing animal handling. Here, we describe a novel 4-day (4-d) continuously running task measuring discrimination- and reversal learning in an automated home cage (CognitionWall DL/RL task) that largely eliminates these limitations...
November 2016: Learning & Memory
https://www.readbyqxmd.com/read/27918065/a-statistical-proposal-for-selecting-a-data-depending-threshold-in-neurobiology
#15
P Finotelli, F Panzica, P Dulio, F Rotondi, G Varotto
In this paper we propose a new methodology for introducing thresholds in the analysis of neuro- biological databases. Often, in Neuroscience, absolute thresholds are adopted. This is done by cutting the data below (or above) predetermined values of the involved parameters, without an analysis of the distribution of the collected data concerning the phenomenon under investigation. Despite an absolute threshold could be rigorously defined in terms of physic parameters, it can be influenced by many different subjective aspects, including cognitive processes, and individual adaptation to the external stimuli...
June 1, 2016: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/27917383/hakim-adams-syndrome-an-unusual-cause-of-reversible-postoperative-coma
#16
Mohamed Saleh, Marine Bouex
We report the case of a 72-year-old patient presenting in our ICU with persistent postoperative coma in a context of recent unexplored neurological dysfunction. Detailed medical history taking from the patient's family revealed he recently suffered from gait instability, urinary incontinence, and slight cognitive impairment. These constituted the clinical triad of normal pressure hydrocephalus syndrome. The presence of normal cerebrospinal fluid (CSF) pressure and distinctive radiological findings confirmed the diagnosis of normal pressure hydrocephalus or Hakims-Adams syndrome...
2016: Frontiers in Medicine
https://www.readbyqxmd.com/read/27916427/tea-cocoa-coffee-and-affective-disorders-vicious-or-virtuous-cycle
#17
REVIEW
Tatiana García-Blanco, Alberto Dávalos, Francesco Visioli
BACKGROUND: The prevalence of psychiatric disorders is increasing worldwide, which underscores the importance of increasing research in this field, in terms of better detection, prevention based on improvement of lifestyle and diet, and effectiveness of treatment. Increasing evidence suggest that diet and exercise can affect proper neuronal development and physiology and protect the brain from neurological illnesses or injuries. Of note, cocoa, tea, and coffee are being actively investigated because they are rich in (poly)phenolic compounds that can modulate mental health, namely brain plasticity, behavior, mood, depression, and cognition...
November 25, 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/27915588/reversible-cerebral-vasoconstriction-syndrome
#18
Michael Perdices, Geoffrey Herkes
Reversible cerebral vasoconstriction syndrome (RCVS) is a relatively rare, non-progressive angiopathy frequently heralded by severe thunderclap headache. It is characterised by vasoconstriction of cerebral arteries which usually resolves within three months of onset. Transient focal neurological signs may occur, and persistent deficits associated with haemorrhagic comorbidities have been reported in a small percentage of individuals. In this paper we report the case of RH, a 36-year-old woman who presented at a university teaching hospital in Sydney with a clinical history and radiological evidence consistent with RCVS...
December 5, 2016: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/27914825/amelioration-of-ischemia-reperfusion-induced-functional-and-biochemical-deficit-in-mice-by-ocimum-kilimandscharicum-leaf-extract
#19
Varinder Singh, Pawan Krishan, Nirmal Singh, Amit Kumar, Richa Shri
The genus Ocimum (family Lamiaceae) has been revered for its diverse biological activities. Various species have been used traditionally to treat CNS disorders and are proven to have neuroprotective effect that is often attributed to their significant antioxidant activity. Ocimum kilimandscharicum (Karpoora Thulasi), a prominent member of this genus is reported to have marked antioxidant activity but its neuroprotective potential has not been explored. Thus, present study was designed to evaluate the cerebroprotective effect of O...
November 30, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27913818/-amyloid-positron-emission-tomography-with-18-%C3%A2-f-florbetaben-in-the-diagnostic-workup-of-dementia-patients
#20
S Schönecker, C Prix, T Raiser, N Ackl, E Wlasich, G Stenglein-Krapf, E Mille, M Brendel, O Sabri, M Patt, H Barthel, P Bartenstein, J Levin, A Rominger, A Danek
BACKGROUND: To this day the definite diagnosis of Alzheimer's disease still relies on post-mortem histopathological detection of neurofibrillary tangles and beta-amyloid deposits. Amyloid positron emission tomography (PET) is a new diagnostic tool that enables the in vivo quantification of pathological beta-amyloid deposits. The aim of the current study was to evaluate to what extent (18)F-florbetaben-PET (FBB-PET) influences the diagnosis of patients with dementia. MATERIAL AND METHODS: Imaging with FBB-PET was performed on 33 patients from our outpatient department for cognitive neurology...
December 2, 2016: Der Nervenarzt
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