keyword
https://read.qxmd.com/read/38305218/bibliometric-analysis-of-childhood-onset-systemic-lupus-erythematosus-from-2000-to-2022
#1
JOURNAL ARTICLE
Hao Yu, Xintong Xie, Guangliang Wei, Huidong Chen, Xue Zhang, Youxian He, Mengxiang Li, Chengsong He, Yue He, Jie Chen
BACKGROUND: Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disorder. When SLE occurs in individuals under the age of 18, it is referred to as childhood-onset SLE (cSLE). Currently, there is a dearth of bibliometric research pertaining to cSLE. METHOD: Relevant studies in the field of cSLE from 2000 to 2022 were screened from the Web of Science Core Collection (WoSCC). CiteSpace and VOSviewer software were used to visualize the annual publications, countries, institutions, authors, journals, keywords, and references, after which the authors conducted the scientific analysis...
February 2, 2024: Lupus
https://read.qxmd.com/read/38181265/bibliometric-analysis-of-lupus-nephritis-in-children-from-1999-to-2022-a-review
#2
REVIEW
Yunhong Ma, Shuangyi Wang, Fei Luo, Yuan Zhang, Juanjuan Diao
Lupus nephritis (LN) is a complication of systemic lupus erythematosus and a damaging disease of the kidney. The injury of LN in children is more serious than that in adults. However, the literature in this field is numerous and complex, which brings great challenges for researchers to extract information. The purpose of this study is to carry out bibliometric analysis and visualization of published literatures, and identify current research hotspots and future research trends in this field. Literature was retrieved from the Web Of Science database from 1999 to 2022...
January 5, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38178067/a-rare-manifestation-of-sting-associated-vasculopathy-with-onset-in-infancy-a-case-report
#3
JOURNAL ARTICLE
Sophia Weidler, Sarah Koss, Christine Wolf, Nadja Lucas, Jürgen Brunner, Min Ae Lee-Kirsch
BACKGROUND: STING-associated vasculopathy with onset in infancy (SAVI) is a rare type I interferonopathy caused by heterozygous variants in the STING gene. In SAVI, STING variants confer a gain-of-function which causes overactivation of type I interferon (IFN) signaling leading to autoinflammation and various degrees of immunodeficiency and autoimmunity. CASE PRESENTATION: We report the case of a 5 year old child and his mother, both of whom presented with systemic inflammatory symptoms yet widely varying organ involvement, disease course and therapeutic response...
January 4, 2024: Pediatric Rheumatology Online Journal
https://read.qxmd.com/read/37433880/towards-a-novel-clinical-outcome-assessment-for-systemic-lupus-erythematosus-first-outcomes-of-an-international-taskforce
#4
REVIEW
Kathryn Connelly, Laura E Eades, Rachel Koelmeyer, Darshini Ayton, Vera Golder, Rangi Kandane-Rathnayake, Kate Gregory, Hermine Brunner, Laurie Burke, Laurent Arnaud, Anca Askanase, Cynthia Aranow, Ed Vital, Guillermo Pons-Estel, Khadija Dantata, Jeanette Andersen, Alain Cornet, Joy Buie, Ying Sun, Yoshiya Tanaka, Lee Simon, Youmna Lahoud, Alan Friedman, Kenneth Kalunian, Qing Zuraw, Victoria Werth, Sandra Garces, Eric F Morand
Systemic lupus erythematosus (SLE) is a disease of high unmet therapeutic need. The challenge of accurately measuring clinically meaningful responses to treatment has hindered progress towards positive outcomes in SLE trials, impeding the approval of potential new therapies. Current primary end points used in SLE trials are based on legacy disease activity measures that were neither specifically designed for the clinical trial context, nor developed according to contemporary recommendations for clinical outcome assessments (COAs), such as that substantial patient input should be incorporated into their design...
September 2023: Nature Reviews. Rheumatology
https://read.qxmd.com/read/37429670/treatment-patterns-in-paediatric-and-adult-patients-with-sle-a-retrospective-claims-database-study-in-the-usa
#5
JOURNAL ARTICLE
Hermine I Brunner, Aisha Vadhariya, Christina Dickson, Wallace Crandall, Casey Kar-Chan Choong, Julie A Birt, Nicolino Ruperto, Athimalaipet V Ramanan
OBJECTIVE: To assess real-world treatment regimens and patterns in childhood-onset SLE (cSLE) and adult-onset SLE (aSLE) cohorts, including similarities in treatments, duration of use and adherence. METHODS: This retrospective study utilised data from Merative L.P. MarketScan Research Databases (USA). Index date was the date of first SLE diagnosis (2010-2019). Patients aged <18 years (cSLE) and ≥18 years (aSLE) at index date with confirmed SLE diagnosis and ≥12 months continuous enrolment during pre-index and post-index periods were included...
July 2023: Lupus Science & Medicine
https://read.qxmd.com/read/37253553/usefulness-of-the-lupus-low-disease-activity-state-as-a-treatment-target-in-childhood-onset-sle
#6
JOURNAL ARTICLE
Ellen M Cody, Bridget E Wilson, Ekemini A Ogbu, Jennifer L Huggins, Chen Chen, Tingting Qiu, Tracy V Ting, Francisco Flores, Bin Huang, Hermine I Brunner
OBJECTIVE: Treat-to-target (T2T) strategies are advocated to improve prognosis in childhood-onset SLE (cSLE). Proposed T2T states include SLEDAI score of <u><</u>4 (SLEDAI-LD), limited corticosteroid use (low-CS), and lupus low disease activity state (LLDAS). We sought to compare T2T states for their association with cSLE prognosis under consideration of relevant disease characteristics such as pre-existing damage, race and lupus nephritis (LN). METHODS: Longitudinal data from 165 patients enrolled in the Cincinnati Lupus Registry were included...
May 2023: Lupus Science & Medicine
https://read.qxmd.com/read/37196635/preclinical-characterization-of-the-toll-like-receptor-7-8-antagonist-mhv370-for-lupus-therapy
#7
JOURNAL ARTICLE
Stuart Hawtin, Cédric André, Géraldine Collignon-Zipfel, Simone Appenzeller, Bettina Bannert, Lea Baumgartner, Damian Beck, Claudia Betschart, Thomas Boulay, Hermine I Brunner, Melanie Ceci, Jonathan Deane, Roland Feifel, Enrico Ferrero, Diego Kyburz, Frederique Lafossas, Pius Loetscher, Christina Merz-Stoeckle, Pierre Michellys, Barbara Nuesslein-Hildesheim, Friedrich Raulf, James S Rush, Giulia Ruzzante, Thomas Stein, Samantha Zaharevitz, Grazyna Wieczorek, Richard Siegel, Peter Gergely, Tamas Shisha, Tobias Junt
Genetic and in vivo evidence suggests that aberrant recognition of RNA-containing autoantigens by Toll-like receptors (TLRs) 7 and 8 drives autoimmune diseases. Here we report on the preclinical characterization of MHV370, a selective oral TLR7/8 inhibitor. In vitro, MHV370 inhibits TLR7/8-dependent production of cytokines in human and mouse cells, notably interferon-α, a clinically validated driver of autoimmune diseases. Moreover, MHV370 abrogates B cell, plasmacytoid dendritic cell, monocyte, and neutrophil responses downstream of TLR7/8...
May 16, 2023: Cell reports medicine
https://read.qxmd.com/read/36715772/urine-biomarker-score-captures-response-to-induction-therapy-with-lupus-nephritis
#8
JOURNAL ARTICLE
Ellen M Cody, Scott E Wenderfer, Kathleen E Sullivan, Alfred H J Kim, Wesley Figg, Harneet Ghumman, Tingting Qiu, Bin Huang, Prasad Devarajan, Hermine I Brunner
BACKGROUND: The Renal Activity Index for Lupus (RAIL) consists of urine protein assessment of neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, monocyte chemotactic protein 1, adiponectin, hemopexin, and ceruloplasmin, which non-invasively identifies lupus nephritis (LN). We aimed to delineate RAIL scores with inactive versus active LN and changes over time with response to LN induction therapy. METHODS: There were 128 pediatric patients with systemic lupus erythematosus (SLE) and age-matched healthy controls recruited in a prospective case control study, with kidney biopsy confirmation of LN...
January 30, 2023: Pediatric Nephrology
https://read.qxmd.com/read/36251074/acute-kidney-injury-requiring-kidney-replacement-therapy-in-childhood-lupus-nephritis-a-cohort-study-of-the-pediatric-nephrology-research-consortium-and-childhood-arthritis-and-rheumatology-research-alliance
#9
JOURNAL ARTICLE
Brian R Stotter, Ellen Cody, Hongjie Gu, Ankana Daga, Larry A Greenbaum, Minh Dien Duong, Alexandra Mazo, Beatrice Goilav, Alexis Boneparth, Mahmoud Kallash, Ahmed Zeid, Wacharee Seeherunvong, Rebecca R Scobell, Issa Alhamoud, Caitlin E Carter, Siddharth Shah, Caroline E Straatmann, Bradley P Dixon, Jennifer C Cooper, Raoul D Nelson, Deborah M Levy, Hermine I Brunner, Priya S Verghese, Scott E Wenderfer
BACKGROUND: Acute kidney injury (AKI) is common in lupus nephritis (LN) and a risk factor for development of chronic kidney disease. In adults with LN, AKI severity correlates with the incidence of kidney failure and patient survival. Data on AKI outcomes in children with LN, particularly those requiring kidney replacement therapy (KRT), are limited. METHODS: A multicenter, retrospective cohort study was performed in children diagnosed between 2010 and 2019 with LN and AKI stage 3 treated with dialysis (AKI stage 3D)...
October 17, 2022: Pediatric Nephrology
https://read.qxmd.com/read/36186297/cross-cultural-adaptation-and-initial-validation-of-the-brazilian-portuguese-version-of-the-pediatric-automated-neuropsychological-assessment-metrics
#10
JOURNAL ARTICLE
Jaqueline Cristina de Amorim, Simone Thiemi Kishimoto, Cibele Longobardi Cutinhola Elorza, Flávia Alegretti Cavaletti, Roberto Marini, Clovis Artur Silva, Claudia Saad-Magalhães, Paula Teixeira Fernandes, Hermine I Brunner, Simone Appenzeller
Automated neuropsychiatric batteries have been used in research and clinical practice, including for chronic diseases, such as Systemic Lupus Erythematosus. The Pediatric Automated Neuropsychological Assessment Metrics battery (Ped-ANAM), originally developed for use in American-English speaking individuals, allows tracking of cognitive functions. It can be applied to people over 9 years old. The aim of this study was to translate and present initial validation data from the Ped-ANAM into Brazilian-Portuguese...
2022: Frontiers in Psychology
https://read.qxmd.com/read/35967565/stability-of-novel-urinary-biomarkers-used-for-lupus-nephritis
#11
JOURNAL ARTICLE
Ellen M Cody, James E Rose, Bin Huang, Tingting Qiu, Hermine I Brunner, Prasad Devarajan
Background: The Renal Activity Index for Lupus (RAIL) is a composite score of six urinary biomarkers (neutrophil gelatinase-associated lipocalin (NGAL), monocyte chemoattractant protein-1 (MCP-1), kidney injury molecule-1 (KIM-1), ceruloplasmin, adiponectin, and hemopexin) used to monitor lupus nephritis activity in children. We tested stability of RAIL biomarkers prior to meaningful clinical use. Methods: Urine samples were tested by ELISA under shipping conditions, freeze/thaw, ambient and longer-term storage...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/35568436/clinical-measurement-of-lupus-nephritis-activity-is-inferior-to-biomarker-based-activity-assessment-using-the-renal-activity-index-for-lupus-nephritis-in-childhood-onset-systemic-lupus-erythematosus
#12
JOURNAL ARTICLE
Najla Aljaberi, Scott E Wenderfer, Arjun Mathur, Tingting Qiu, Steffy Jose, Angela Merritt, James Rose, Prasad Devarajan, Bin Huang, Hermine Brunner
OBJECTIVES: The renal activity index for lupus (RAIL) measures lupus nephritis (LN) activity considering urine levels of 6 biomarkers (neutrophil gelatinase-associated lipocalin, monocyte chemoattractant protein-1, kidney injury molecule-1, adiponectin, haemopexin, ceruloplasmin). We aimed to compare the accuracy of the RAIL and the renal domain-score of the SLE disease activity index (rSLEDAI) in detecting LN activity. METHODS: Random urine samples of patients with childhood-onset SLE with and without LN were assayed and scores of the RAIL, and RAIL standardised for urine creatinine (RAIL-Cr) were calculated...
May 2022: Lupus Science & Medicine
https://read.qxmd.com/read/35529329/working-towards-a-treat-to-target-protocol-in-juvenile-proliferative-lupus-nephritis-a-survey-of-pediatric-rheumatologists-and-nephrologists-in-germany-and-austria
#13
JOURNAL ARTICLE
Kristina Vollbach, Catharina Schuetz, Christian M Hedrich, Fabian Speth, Kirsten Mönkemöller, Jürgen Brunner, Ulrich Neudorf, Christoph Rietschel, Anton Hospach, Tilmann Kallinich, Claas Hinze, Norbert Wagner, Burkhard Tönshoff, Lutz T Weber, Kay Latta, Julia Thumfart, Martin Bald, Dagobert Wiemann, Hildegard Zappel, Klaus Tenbrock, Dieter Haffner
Background: To describe treatment practices for juvenile proliferative lupus nephritis (LN) class III and IV of pediatric rheumatologists and nephrologists in Germany and Austria in preparation for a treat-to-target treatment protocol in LN. Methods: Survey study by members of the Society for Pediatric and Adolescent Rheumatology (GKJR) and the German Society for Pediatric Nephrology (GPN) on diagnostics and (concomitant) therapy of LN. Results: Fifty-eight physicians completed the survey...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/34965782/hydroxychloroquine-blood-levels-predicts-flare-in-childhood-onset-lupus-nephritis
#14
JOURNAL ARTICLE
Verena Andrade Balbi, Clovis Artur Silva, Tatiana Nascimento Pedrosa, Rosa Maria Rodrigues Pereira, Lucia Maria de Arruda Campos, Elaine Pires Leon, Nilo Duarte, Valdemir Melechco Carvalho, Sandra Gofinet Pasoto, Debora Cordeiro do Rosário, Leticia Kolachinski Brandao, Hermine I Brunner, Eloisa Bonfá, Nadia Emi Aikawa
OBJECTIVE: Low hydroxychloroquine (HCQ) blood levels are predictors of flare in adult lupus. Childhood-onset systemic lupus erythematosus (cSLE) has high morbidity with renal involvement in up to 80% of cases. The aim of this study is to determine the HCQ cut-off levels which predicts flare in childhood-onset lupus nephritis (LN). METHODS: Sixty LN patients on HCQ use for at least 6-months were prospectively evaluated at baseline (BL) and about 6-months later for cSLE flare and HCQ blood levels (ng/mL) measured by liquid chromatography-tandem mass spectrometry...
January 2022: Lupus
https://read.qxmd.com/read/34962100/evaluating-the-construct-of-damage-in-systemic-lupus-erythematosus
#15
JOURNAL ARTICLE
Sindhu R Johnson, Dafna D Gladman, Hermine I Brunner, David Isenberg, Ann E Clarke, Megan R W Barber, Laurent Arnaud, Paul R Fortin, Marta Mosca, Alexandre Voskuyl, Susan Manzi, Cynthia Aranow, Anca Askanase, Graciela S Alarcón, Sang-Cheol Bae, Nathalie Costedoat-Chalumeau, Jessica English, Guillermo J Pons-Estel, Bernardo A Pons-Estel, Rebecca Gilman, Ellen Ginzler, John G Hanly, Soren Jacobsen, Kenneth Kalunian, Diane L Kamen, Chynace Lambalgen, Alexandra Legge, S Sam Lim, Anselm Mak, Eric F Morand, Christine Peschken, Michelle Petri, Anisur Rahman, Rosalind Ramsey-Goldman, John A Reynolds, Juanita Romero-Diaz, Guillermo Ruiz-Irastorza, Jorge Sanchez-Guerrero, Elisabet Svenungsson, Zahi Touma, Murray Urowitz, Evelyne Vinet, Ronald F van Vollenhoven, Heather Waldhauser, Daniel Wallace, Asad Zoma, Ian N Bruce
OBJECTIVE: The Systemic Lupus International Collaborating Clinics, American College of Rheumatology and Lupus Foundation of America are developing a revised SLE Damage Index (SDI). Shifts in the concept of damage in SLE have occurred with new insights into disease manifestations, diagnostics, and therapy. We evaluated contemporary constructs in SLE damage to inform development of the revised SDI. METHODS: We conducted a 3-part qualitative study of international SLE experts...
December 28, 2021: Arthritis Care & Research
https://read.qxmd.com/read/34819388/2021-doris-definition-of-remission-in-sle-final-recommendations-from-an-international-task-force
#16
JOURNAL ARTICLE
Ronald F van Vollenhoven, George Bertsias, Andrea Doria, David Isenberg, Eric Morand, Michelle A Petri, Bernardo A Pons-Estel, Anisur Rahman, Manuel Francisco Ugarte-Gil, Alexandre Voskuyl, Laurent Arnaud, Ian N Bruce, Ricard Cervera, Nathalie Costedoat-Chalumeau, Caroline Gordon, Frédéric A Houssiau, Marta Mosca, Matthias Schneider, Michael M Ward, Graciela Alarcon, Martin Aringer, Anka Askenase, Sang-Cheol Bae, Hendrika Bootsma, Dimitrios T Boumpas, Hermine Brunner, Ann Elaine Clarke, Cindy Coney, László Czirják, Thomas Dörner, Raquel Faria, Rebecca Fischer, Ruth Fritsch-Stork, Murat Inanc, Søren Jacobsen, David Jayne, Annegret Kuhn, Bernadette van Leeuw, Maarten Limper, Xavier Mariette, Sandra Navarra, Mandana Nikpour, Marzena Helena Olesinska, Guillermo Pons-Estel, Juanita Romero-Diaz, Blanca Rubio, Yehuda Schoenfeld, Eloisa Bonfá, Josef Smolen, Y K Onno Teng, Angela Tincani, Michel Tsang-A-Sjoe, Carlos Vasconcelos, Anne Voss, Victoria P Werth, Elena Zakharhova, Cynthia Aranow
OBJECTIVE: To achieve consensus on a definition of remission in SLE (DORIS). BACKGROUND: Remission is the stated goal for both patient and caregiver, but consensus on a definition of remission has been lacking. Previously, an international task force consisting of patient representatives and medical specialists published a framework for such a definition, without reaching a final recommendation. METHODS: Several systematic literature reviews were performed and specific research questions examined in suitably chosen data sets...
November 2021: Lupus Science & Medicine
https://read.qxmd.com/read/34798952/biomarkers-in-childhood-onset-systemic-lupus-erythematosus
#17
REVIEW
Ellen M Cody, Hermine I Brunner
Systemic lupus erythematosus (SLE) is a complex, multisystem chronic autoimmune disease. Because of its diverse phenotypes, diagnosis of SLE can be challenging, and current biomarkers are insufficient. Childhood-onset SLE (cSLE), although less prevalent, has higher morbidity and mortality, and early diagnosis is critical for improving outcomes. Many studies have focused on discovering new biomarkers to better diagnose and monitor SLE and cSLE. Herein, the authors aim to review the most investigated biomarkers in development for cSLE, focusing on those that can be measured in the blood or urine...
February 2022: Rheumatic Diseases Clinics of North America
https://read.qxmd.com/read/34622116/corrigendum-to-successful-urine-multiplex-bead-assay-to-measure-lupus-nephritis-activity-kidney-int-rep-2021-6-1949-1960
#18
Ellen M Cody, Michael R Bennett, Gaurav Gulati, Qing Ma, Mekibib Altaye, Prasad Devarajan, Hermine I Brunner
[This corrects the article DOI: 10.1016/j.ekir.2021.04.016.].
October 2021: KI Reports
https://read.qxmd.com/read/34531304/efficacy-and-safety-of-belimumab-in-paediatric-and-adult-patients-with-systemic-lupus-erythematosus-an-across-study-comparison
#19
JOURNAL ARTICLE
Hermine I Brunner, Carlos Abud-Mendoza, Masaaki Mori, Clarissa A Pilkington, Reema Syed, Syuji Takei, Diego O Viola, Richard A Furie, Sandra Navarra, Fengchun Zhang, Damon L Bass, Gina Eriksson, Anne E Hammer, Beulah N Ji, Mohamed Okily, David A Roth, Holly Quasny, Nicolino Ruperto
OBJECTIVE: To assess the efficacy and safety of belimumab in paediatric versus adult patients with systemic lupus erythematosus (SLE). METHODS: We performed across-study comparisons of patients with active SLE who received belimumab or placebo, plus standard therapy, in PLUTO (paediatric phase II) and BLISS-52, BLISS-76, BLISS-NEA and EMBRACE (adult phase III). Analysed efficacy data included Week 52 SLE Responder Index (SRI)-4 response rate (EMBRACE: SRI with modified Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) proteinuria scoring (SRI-S2K)); SRI-4 response rate (EMBRACE: SRI-S2K) according to baseline disease activity indicators (Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity Index (SELENA-SLEDAI) score; anti-dsDNA/C3/C4 levels); Week 52 SRI-6 response rate; and time to first severe flare (SELENA-SLEDAI Flare Index) over 52 weeks...
September 2021: RMD Open
https://read.qxmd.com/read/34307989/successful-urine-multiplex-bead-assay-to-measure-lupus-nephritis-activity
#20
JOURNAL ARTICLE
Ellen M Cody, Michael R Bennett, Gaurav Gulati, Qing Ma, Mekibib Altaye, Prasad Devarajan, Hermine I Brunner
INTRODUCTION: Lupus nephritis (LN) confers a poor prognosis, mainly from lack of effective laboratory tests to diagnose and to evaluate therapies. We have previously shown that a set of 6 urinary biomarkers (NGAL, KIM-1, MCP-1, adiponectin, hemopexin, and ceruloplasmin) are highly sensitive and specific to identify adult and pediatric patients with active LN using renal biopsy as reference standard. Using these combinatorial urinary biomarkers, the Renal Activity Score for Lupus (RAIL) score was established, with biomarkers measured by enzyme-linked immunosorbent assay (ELISA)...
July 2021: KI Reports
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