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https://www.readbyqxmd.com/read/28441747/associations-between-diet-and-toenail-arsenic-concentration-among-pregnant-women-in-bangladesh-a-prospective-study
#1
Pi-I D Lin, Sabri Bromage, Md Golam Mostofa, Joseph Allen, Emily Oken, Molly L Kile, David C Christiani
This prospective study evaluated the relationship between long-term dietary habits and total arsenic (As) concentration in toenail clippings in a cohort of 1616 pregnant women in the Bangladeshi administrative regions of Sirajdikhan and Pabna Sadar. Diet was assessed at Gestation Week 28 and at Postpartum Month 1, using a locally-validated dish-based semi-quantitative food-frequency questionnaire. Toenail As concentration was analyzed by microwave-assisted acid digestion and inductively coupled plasma mass spectrometry...
April 23, 2017: Nutrients
https://www.readbyqxmd.com/read/28441697/hypertension-management-in-a-population-of-older-adults-in-rural-south-africa
#2
Thiago Veiga Jardim, Sheridan Reiger, Shafika Abrahams-Gessel, F Xavier Gomez-Olive, Ryan G Wagner, Alisha Wade, Till W Bärnighausen, Joshua Salomon, Stephen Tollman, Thomas A Gaziano
OBJECTIVE: Assess awareness, treatment, and control of hypertension, as an indication of its management, in rural South Africa, especially regarding modifiers of these variables. METHODS: A population-representative sample of adults aged at least 40 years residing in the rural Agincourt subdistrict (Mpumalanga Province) covered by a long-term health and sociodemographic surveillance system was recruited. In-person interviews, physical exams, and dried blood spots were collected...
June 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28441664/protection-against-legionnaire-s-disease-recombinant-flagellin-a-of-legionella-pneumophila-can-induce-protective-immunity-against-bacteremia-in-a-balb-c-murine-model
#3
Ashraf Mohabati Mobarez, Roya Ahmadrajabi, Nima Khoramabadi, Ali-Hatef Salmanian
To investigate the immunoprotective effects of the recombinant type A flagellin (FLA), the flaA gene of Legionella pneumophila serogroup 1 strain Paris was cloned into pET28a(+). Recombinant FLA (rFLA) was overexpressed in E. coli BL21 (DE3) and purified by Ni2+ exchange chromatography. Female BALB/c aged 6-8 weeks were immunized with 20 μg of rFLA. Nonimmunized mice along with mice inoculated with a sublethal dose of live L. pneumophila intravenously were considered as negative and positive controls, respectively...
April 26, 2017: Journal of Molecular Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28441659/perioperative-serum-carcinoembryonic-antigen-levels-predict-recurrence-and-survival-of-patients-with-pathological-t2-4-gastric-cancer-treated-with-curative-gastrectomy
#4
Hiroaki Uda, Mitsuro Kanda, Chie Tanaka, Daisuke Kobayashi, Kenichi Inaoka, Yuri Tanaka, Masamichi Hayashi, Naoki Iwata, Suguru Yamada, Tsutomu Fujii, Hiroyuki Sugimoto, Kenta Murotani, Michitaka Fujiwara, Yasuhiro Kodera
BACKGROUND/AIMS: Do serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA) 19-9 levels serve as prognostic indicators in patients with gastric cancer (GC)? This is a question that has long been disputed. The aim of this study was to evaluate the significance of perioperative serum levels of CEA and CA19-9 for predicting the recurrence and long-term survival after patients with pT2-4 GC undergo curative gastrectomy. METHODS: This study included 251 patients with radically resected pT2-4 GC without preoperative treatment...
April 26, 2017: Digestive Surgery
https://www.readbyqxmd.com/read/28441624/various-soil-amendments-and-environmental-wastes-affect-the-im-mobilization-and-phytoavailability-of-potentially-toxic-elements-in-a-sewage-effluent-irrigated-sandy-soil
#5
Sabry M Shaheen, Mohamed S Shams, Mohamed R Khalifa, Mohamed A El-Dali, Jörg Rinklebe
Contamination of long-term sewage effluent irrigated soils by potentially toxic elements (PTEs) is a serious concern due to its high environmental and health risk. Our scientific hypothesis is that soil amendments can cause contradictory effects on the element mobilization and phytoavailability depending on the type of element and amendment. Therefore, we aimed to assess the impact of the application (1%) of several low cost amendments and environmental wastes on the (im)mobilization, availability, and uptake of Al, Cd, Cr, Cu, Fe, Mn, Ni, and Zn by sorghum (Sorghum bicolor) in a long term sewage effluent irrigated sandy soils collected from Egypt...
April 22, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28441535/investigation-of-the-vertical-distribution-and-speciation-of-137-cs-in-soil-profiles-at-burnt-and-unburnt-forest-sites-in-the-belarusian-exclusion-zone
#6
M Dowdall, Y Bondar, L Skipperud, V Zabrotski, M Nandrup Pettersen, Ø G Selnæs, J E Brown
The effects of fire events on contaminant radionuclides within soils of the Belarusian Exclusion Zone were investigated. A number of cores were taken from locations known to have been subject to fire events in the past as well as a series of cores from nearby unburnt locations. Both burnt and unburnt cores were analyzed for contaminant radionuclides as well as a range of relevant soil parameters. The distribution of (137)Cs between various fractions (reversibly bound, irreversibly bound and insoluble) was analyzed...
April 22, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28441513/antibody-persistence-following-meningococcal-c-conjugate-vaccination-in-children-and-adolescents-infected-with-human-immunodeficiency-virus
#7
Ana Cristina Cisne Frota, Lee H Harrison, Bianca Ferreira, Daniela Menna-Barreto, Raquel Bernardo Nana de Castro, Giselle Pereira da Silva, Ricardo Hugo de Oliveira, Thalita F Abreu, Lucimar G Milagres, Cristina B Hofer
OBJECTIVE: HIV-infected individuals (HIVI) are threatened by meningococcal infection and presented lower response to vaccines. Data are scarce on long-term persistence of human serum bactericidal antibody (hSBA) after a meningococcal C conjugate (MCC) vaccine in HIVI youth; the authors aimed to describe this persistence in HIVI. METHODS: HIVI and HIV uninfected individuals (HIVU), aged 2-18 years, CD4 >15% were recruited. Seroprotection (hSBA ≥1:4) at baseline and at 12-18 months after immunization was evaluated and the association of the different factors with the long-term persistence was calculated using logistic regression...
April 22, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28441483/discovery-of-a-novel-class-of-survival-motor-neuron-2-splicing-modifiers-for-the-treatment-of-spinal-muscular-atrophy
#8
Emmanuel Pinard, Luke Green, Michael Reutlinger, Marla Weetall, Nikolai N Naryshkin, John Baird, Karen S Chen, Sergey V Paushkin, Friedrich Metzger, Hasane Ratni
Spinal muscular atrophy (SMA) is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene, resulting in low levels of functional SMN protein. We have reported recently the identification of small molecules (coumarins, iso-coumarins and pyrido-pyrimidinones) that modify the alternative splicing of SMN2, a paralogous gene to SMN1, restoring the survival motor neuron (SMN) protein level in mouse models of SMA. Herein, we report our efforts to identify a novel chemotype as one strategy to potentially circumvent safety concerns from earlier derivatives, such as in-vitro phototoxicity and in-vitro mutagenicity associated with compounds 1 and 2 or the in-vivo retinal findings observed in a long term chronic tox study with 3 at high exposures only...
April 25, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28441428/increased-long-term-risk-of-major-adverse-cardiovascular-events-in-patients-with-carbon-monoxide-poisoning-a-population-based-study-in-taiwan
#9
Chung-Shun Wong, Ying-Chin Lin, Li-Chin Sung, Tzu-Ting Chen, Hon-Ping Ma, Yung-Ho Hsu, Shin-Han Tsai, Yuh-Feng Lin, Mei-Yi Wu
BACKGROUND: Carbon monoxide (CO) poisoning may cause toxicity to the cardiovascular system. However, the association between CO poisoning and the risk of major adverse cardiovascular events (MACE) remains unestablished. We investigated the incidence of MACE after CO poisoning in Taiwan and evaluated whether CO-poisoned individuals had a higher risk of MACE than did the general population. METHODS: Using Taiwan's National Health Insurance Research Database (NHIRD) during 2005-2013, a nationwide population-based cohort study was conducted among patients who experienced CO poisoning between 2005 and 2013...
2017: PloS One
https://www.readbyqxmd.com/read/28441423/reproductive-parameters-and-cub-survival-of-brown-bears-in-the-rusha-area-of-the-shiretoko-peninsula-hokkaido-japan
#10
Michito Shimozuru, Masami Yamanaka, Masanao Nakanishi, Jun Moriwaki, Fumihiko Mori, Masakatsu Tsujino, Yuri Shirane, Tsuyoshi Ishinazaka, Shinsuke Kasai, Takane Nose, Yasushi Masuda, Toshio Tsubota
Knowing the reproductive characteristics of a species is essential for the appropriate conservation and management of wildlife. In this study, we investigated the demographic parameters, including age of primiparity, litter size, inter-birth interval, reproductive rate, and cub survival rate, of Hokkaido brown bears (Ursus arctos yesoensis) in the Rusha area on the Shiretoko Peninsula, Hokkaido, Japan, based on a long-term, individual-based monitoring survey. A total of 15 philopatric females were observed nearly every year from 2006 to 2016, and these observations were used to estimate reproductive parameters...
2017: PloS One
https://www.readbyqxmd.com/read/28441407/changes-in-secondary-metabolites-in-the-halophytic-putative-crop-species-crithmum-maritimum-l-triglochin-maritima-l-and-halimione-portulacoides-l-aellen-as-reaction-to-mild-salinity
#11
Christian Boestfleisch, Jutta Papenbrock
It is assumed that salinity enhances the concentration of valuable metabolites in halophytes. The objective was to find a salt concentration and a point in time at which the yield for the valuable metabolites was maximal. Therefore, three different halophyte species were grown under different salinities and harvested over a period from shortly after stress induction up to three weeks. Various reaction patterns were found in the metabolite composition of the analyzed plant material. Halimione portulacoides showed a "short term response", indicated by an increase in all metabolites analyzed after a few hours, whereas Crithmum maritimum showed a "long term response" through accumulation of proline starting after days...
2017: PloS One
https://www.readbyqxmd.com/read/28441395/molecular-phylogeny-of-oncaeidae-copepoda-using-nuclear-ribosomal-internal-transcribed-spacer-its-rdna
#12
Iole Di Capua, Fulvio Maffucci, Raimondo Pannone, Maria Grazia Mazzocchi, Elio Biffali, Alberto Amato
Copepods belonging to the Oncaeidae family are commonly and abundantly found in marine zooplankton. In the Mediterranean Sea, forty-seven oncaeid species occur, of which eleven in the Gulf of Naples. In this Gulf, several Oncaea species were morphologically analysed and described at the end of the XIX century by W. Giesbrecht. In the same area, oncaeids are being investigated over seasonal and inter-annual scales at the long-term coastal station LTER-MC. In the present work, we identified six oncaeid species using the nuclear ribosomal internal transcribed spacers (ITS rDNA) and the mitochondrial cytochrome c oxidase subunit I (mtCOI)...
2017: PloS One
https://www.readbyqxmd.com/read/28441369/cardiac-magnetic-resonance-imaging-in-oncology
#13
Daniel Jeong, Aarti Patel, Christopher J Francois, Kenneth L Gage, Michael G Fradley
BACKGROUND: Cardiac magnetic resonance imaging (MRI) is emerging as an important diagnostic modality in the management of cardiovascular-related dysfunction in oncological diseases. Advances in imaging techniques have enhanced the detection and evaluation of cardiac masses; meanwhile, innovative applications have created a growing role for cardiac MRI for the management of cardiotoxicity caused by cancer therapies. METHODS: An overview is provided of the clinical indications and technical considerations of cardiac MRI...
April 2017: Cancer Control: Journal of the Moffitt Cancer Center
https://www.readbyqxmd.com/read/28441341/a-long-term-treatment-with-arachidonyl-2-chloroethylamide-combined-with-valproate-increases-neurogenesis-in-a-mouse-pilocarpine-model-of-epilepsy
#14
Marta Andres-Mach, Mirosław Zagaja, Agnieszka Haratym-Maj, Radosław Rola, Maciej Maj, Joanna Haratym, Monika Dudra-Jastrzębska, Jarogniew J Łuszczki
Rational polytherapy in the treatment of refractory epilepsy has been the main therapeutic modality for several years. In treatment with two or more antiepileptic drugs (AEDs), it is of particular importance that AEDs be selected based on their high anticonvulsant properties, minimal side effects, and impact on the formation of new neurons. The aim of the study was to conduct an in vivo evaluation of the relationship between treatments with synthetic cannabinoid arachidonyl-2'-chloroethylamide (ACEA) alone or in combination with valproic acid (VPA) and hippocampal neurogenesis in a mouse pilocarpine model of epilepsy...
April 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28441336/neurobehavioral-outcomes-of-mild-traumatic-brain-injury-a-mini-review
#15
REVIEW
Robert Eme
Traumatic brain injury outcomes can be classified as acute or chronic. Acute outcomes refer to injuries that occur immediately at the time of the injury and subsequent short-term consequences. Chronic outcomes refer to adverse outcomes that are more long-term. In mild traumatic brain injury, recovery from acute outcomes typically occurs very rapidly, i.e., within 2 weeks, with full recovery expected by 90 days. However, some 10%-15% individuals can remain symptomatic for much longer with an outcome termed post-concussive syndrome...
April 25, 2017: Brain Sciences
https://www.readbyqxmd.com/read/28441315/an-overview-of-chronic-spinal-pain-revisiting-diagnostic-categories-and-exploring-an-evolving-role-for-neurostimulation
#16
Ashwini Sharan, Jonathan Riley, Christian Hoelscher
STUDY DESIGN: Topic Overview OBJECTIVE.: To describe the varied etiologies resulting in chronic spinal pain and review the current available evidence for treatments. SUMMARY OF BACKGROUND DATA: Chronic pain conditions, especially those that affect the axial back and radiate to the extremities, affect a large population. This results in pronounced disability and a high socioeconomic burden. Our understanding of the underlying mechanisms for chronic pain is limited...
April 24, 2017: Spine
https://www.readbyqxmd.com/read/28441314/radiologic-parameters-can-affect-the-preoperative-decision-making-of-three-column-spinal-osteotomies-in-the-treatment-of-severe-and-stiff-kyhposcoliosis
#17
Hengwei Fan, Xueshi Li, Zifang Huang, Wenyuan Sui, Jingfan Yang, Yaolong Deng, Chongwen Wang, Chuandong Lang, Junlin Yang
STUDY DESIGN: Retrospective analysis. OBJECTIVE: To evaluate radiologic parameters affect spine surgeon's osteotomy choice on patients with severe and stiff thoracic kyphoscoliosis. SUMMARY OF BACKGROUD DATA: Three-column osteotomies were developed to address severe and stiff kyphoscolisis. Current choice on osteotomies based on the morphology of kyphosis, global balance and locations of the main curvature, however, quantitative basis for decision-making is still lacking...
April 24, 2017: Spine
https://www.readbyqxmd.com/read/28441313/clinical-evidence-for-spinal-cord-stimulation-for-failed-back-surgery-syndrome-fbss-systematic-review
#18
Leonardo Kapural, Erika Peterson, David A Provenzano, Peter Staats
STUDY DESIGN: A systematic review OBJECTIVE.: A systematic literature review of the clinical data from prospective studies was undertaken to assess the efficacy of spinal cord stimulation (SCS) in the treatment of FBSS in adults. SUMMARY OF BACKGROUND DATA: For patients with unrelenting back pain due to mechanical instability of the spine, degenerative disc disease, spinal injury, or deformity, spinal surgery is a well-accepted treatment option; however, even after surgical intervention, many patients continue to experience chronic back pain that can be notoriously difficult to treat...
April 24, 2017: Spine
https://www.readbyqxmd.com/read/28441284/comparison-of-homogeneous-and-particulate-lung-dose-rates-for-small-mammals
#19
Emily Caffrey, Mathew Johansen, Jarvis Caffrey, Kathryn Higley
Small, highly radioactive fragments of material incorporated into metallic matrices are commonly found at nuclear weapons test and accident sites and can be inhaled by wildlife. Inhaled particles often partition heterogeneously in the lungs, with aggregation occurring in the periphery of the lung, and are tenaciously retained. However, dose rates are typically calculated as if the material were homogeneously distributed throughout the entire organ. Here the authors quantify the variation in dose rates for alpha-, beta-, and gamma-emitting radionuclides with particle sizes from 0...
June 2017: Health Physics
https://www.readbyqxmd.com/read/28441214/the-osteo-odonto-keratoprosthesis
#20
Mehran Zarei-Ghanavati, Venkata Avadhanam, Alfonso Vasquez Perez, Christopher Liu
PURPOSE OF REVIEW: To describe the practice of and recent developments in the osteo-odonto-keratoprosthesis. RECENT FINDINGS: Formal psychological assessment and support have been described. A sub-aqua system for fashioning the osteo-odonto-keratoprosthesis lamina; adoption of thicker laminae; use of bisphosphonate drugs; advances in laminar imaging; and use of bone augmentation and bone morphogenetic protein have been described for prevention, detection, and management of laminar resorption...
April 24, 2017: Current Opinion in Ophthalmology
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