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https://www.readbyqxmd.com/read/29786579/operative-treatment-of-corrosive-esophageal-strictures
#1
Volodymyr O Shaprynskyi, Yevhen V Shaprynskyi, Yaroslav V Karyi, Serhii A Lysenko, Oleg O Vorovskyi, Andrii I Semenenko
OBJECTIVE: Introduction: Nowadays operative treatment of corrosive esophageal strictures remains one of the difficult and unsolved problems in surgery. The level of postoperative complications such as anastomotic leak (develops in 7-30% of cases), infections, pneumonia, pleural empyema, mediastinitis, peritonitis, postoperative corrosive strictures is still rather high. The aim of our work was to improve the results of surgical treatment of patients with corrosive esophageal strictures by analyzing and refining on conservative therapy options as well as differentiated approach to each operative treatment method...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29785394/notch-signaling-pathway-is-inhibited-in-the-development-of-barrett-s-esophagus-an-in-vivo-and-in-vitro-study
#2
Yun-Cang Wang, Zhi-Qiang Wang, Yong Yuan, Tao Ren, Peng-Zhi Ni, Long-Qi Chen
Objective: To explore the role of Notch signaling in the development of Barrett's esophagus. Methods: Patients with esophagectomy and gastric interposition were recruited as a human model of gastroesophageal reflux disease. The expressions of Notch signaling genes in normal esophagus from surgical specimen and columnar metaplasia in the esophageal remnant after esophagectomy were evaluated by real time quantitative Polymerase Chain Reaction (RT-qPCR) and immunohistochemistry (IHC)...
2018: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29777403/correction-to-clinical-outcomes-and-evaluation-of-laparoscopic-proximal-gastrectomy-with-double-flap-technique-for-early-gastric-cancer-in-the-upper-third-of-the-stomach
#3
Masaru Hayami, Naoki Hiki, Souya Nunobe, Shinji Mine, Manabu Ohashi, Koshi Kumagai, Satoshi Ida, Masayuki Watanabe, Takeshi Sano, Toshiharu Yamaguchi
In the original article on page 1636, first line, the reference cited for Kamikawa et al. is incorrect. The correct reference is as follows: Kamikawa YKT, Kamiyama S, Satomoto K. A new procedure of esophagogastrostomy to prevent reflux following proximal gastrectomy (in Japanese). Shoukakigeka. 2001;24:1053-60.
May 17, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29774942/-progress-and-controversy-on-diagnosis-and-treatment-of-gastric-stump-cancer
#4
Zhidong Gao, Yongbai Li, Kewei Jiang, Yingjiang Ye, Shan Wang
Gastric stump cancer (GSC) is a carcinoma arising from the remnant stomach following gastric surgery for benign or malignant disease, and is more common in men. The risk of morbidity has an obvious time dependence. GSC incidence is likely to rise with lengthening of the initial operation interval. The GSC time interval after malignant disease is significantly shorter than that of benign disease. GSC etiologies mainly include duodenogastric reflux and denervation of the gastric mucosa resulting in the change of the gastric environment after gastrectomy and the Helicobacter pylori infection...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774929/-epidemiological-characteristics-and-inducing-factors-of-gastric-stump-cancer
#5
Lin Chen
Gastric stump cancer was initially defined as a carcinoma of the stomach occurring more than 5 years after surgery for gastric or duodenal benign disease. In recent years, as the number of total gastrectomy for benign disease has gradually decreased and the gastric cancer detection and operation rate have annually increased, residual recurrence of primary gastric cancer more than 10 years after gastric cancer surgery has also been considered as gastric stump cancer. The incidence of gastric stump cancer is increasing annually...
May 25, 2018: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/29774546/pepsin-biomarker-mediator-and-therapeutic-target-for-reflux-and-aspiration
#6
REVIEW
Nikki Johnston, Peter W Dettmar, Frank G Ondrey, Rahul Nanchal, Sang-Hyuk Lee, Jonathan M Bock
Extra-esophageal reflux is suspected to cause a wide range of clinical symptoms in the upper airways. Diagnosis and treatment has focused on acid, but realization of the role of nonacid reflux has resulted in research investigating the use of pepsin as a biomarker for gastric reflux and aspiration. Pepsin analysis can complement the use of questionnaires and office-based diagnosis and lessen the dependency on invasive and expensive diagnostic tests. Furthermore, pepsin as a first-line diagnostic biomarker has been shown to improve the accuracy of reflux diagnosis...
May 17, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29770925/esophageal-magnetic-sphincter-augmentation-as-a-novel-approach-to-post-bariatric-surgery-gastroesophageal-reflux-disease
#7
John P Kuckelman, Cody J Phillips, Michael J Derickson, Byron J Faler, Matthew J Martin
BACKGROUND: We sought to evaluate the safety and effectiveness of magnetic sphincter augmentation (MSA) in patients with GERD after bariatric surgery. METHODS: Pre- and post-operative GERD quality of life (G-QOL) surveys were conducted. Standard indications (SI) group or the post-bariatric group (PB) created. Outcomes were compared between groups. RESULTS: Twenty-eight patients analyzed with no losses to follow-up. All patients had preoperative testing confirming normal motility and presence of GERD...
May 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29770154/effects-of-platycodin-d-on-reflux-esophagitis-due-to-modulation-of-antioxidant-defense-systems
#8
Su-Yeon Cho, Chang-Hyun Song, Ji-Eun Lee, Seong Hun Choi, Sae-Kwang Ku, Soo-Jin Park
Aims: The effects of platycodin D (PD) pretreatment were examined in reflux esophagitis (RE) induced rats. Methods: Sham, control, and omeprazole (OMP) group were pretreated with distilled water or OMP as a reference, respectively, and PD pretreated groups were given 3 different PD doses once a day for 7 days. One hour after last pretreatment, RE was induced by ligation of the forestomach and pylorus. At 8 h after operation, all animals were sacrificed. Results: PD showed significant dose-dependent reduction of gastric secretion, myeloperoxidase activity, and RE lesion areas of esophagus and stomach mucosa...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29768387/optimal-reconstruction-methods-after-distal-gastrectomy-for-gastric-cancer-a-systematic-review-and-network-meta-analysis
#9
Zhaolun Cai, Ye Zhou, Chenxiao Wang, Yiqiong Yin, Yuan Yin, Chaoyong Shen, Xiaonan Yin, Zhixin Chen, Bo Zhang
BACKGROUND: The choice of anastomosis methods including Billroth I, Billroth II, and Roux-en-Y after a distal gastrectomy is still controversial. The conventional meta-analyses assessing 2 alternative treatments were not powered to compare differences in clinical outcomes. To guide treatment decisions in patients with gastric cancer (GC) after distal gastrectomy, we did a systematic review and network meta-analysis to identify the best reconstruction method. METHODS: We systematically searched PubMed, EMBASE, the Cochrane Library for randomized controlled trials comparing the outcomes of Billroth I, Billroth II, or Roux-en-Y reconstruction after distal subtotal gastrectomy for patients with GC, then we performed a direct meta-analysis and Bayesian network meta-analysis to pooled odds ratios (OR) or weighted mean differences (WMD) with 95% credible intervals (CrI) with random effects model...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29763614/association-of-oral-helicobacter-pylori-with-gastric-complications
#10
Shazia A Ansar, Mehir Un Nisa Iqbal, Taseer A Khan, Shahana U Kazmi
AIM: This study was aimed to identify the presence of Helicobacter pylori (H. pylori) genes in oral mucosa and find out their relationship between oral H. pylori infection and gastric complications. METHODS: This study is a case control study consists of 567 subjects with periodontal infection (278 gastric complication cases and 289 controls normal gastric intestinal mucosa) with age range of 20-80 years. Oral health status was recorded by calculating oral hygiene index (OHI), probing depths (PD) and clinical attachment loss (CAL)...
May 12, 2018: Life Sciences
https://www.readbyqxmd.com/read/29760783/minor-digestive-symptoms-and-their-impact-in-the-general-population-a-cluster-analysis-approach
#11
Diane L'Heureux-Bouron, Sophie Legrain-Raspaud, Helen R Carruthers, P J Whorwell
Background: The classification and treatment of patients who do not meet the criteria for a functional gastrointestinal (GI) disorder has not been well established. This study aimed to record the prevalence of minor digestive symptoms (MDSs) in the general population attempting to divide them into symptom clusters as well as trying to assess their impact and the way sufferers cope with them. Methods: Following face-to-face interviews, a web-based, self-administered questionnaire was designed to capture a range of GI sensations using 34 questions and 12 images depicting abdominal symptoms...
2018: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/29756656/pathophysiology-and-treatment-of-achalasia-in-a-muscle-mechanical-perspective
#12
REVIEW
Hans Gregersen, Kar Man Lo
This review provides a biomechanical perspective on the pathophysiology and treatment of achalasia. The esophagus is efficient in transporting ingested material to the stomach in healthy subjects. A fine balance exists between the peristaltic forces generated in the esophageal body (which herein is defined as the preload) and the resistance in the outlet, the esophago-gastric junction (which is defined as the afterload). Achalasia is a rare esophageal disease that progressively over many years challenges esophageal efficacy...
May 14, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29739175/potent-potassium-competitive-acid-blockers-a-new-era-for-the-treatment-of-acid-related-diseases
#13
REVIEW
Tadayuki Oshima, Hiroto Miwa
Conventional proton pump inhibitors (PPIs) are used as a first-line therapy to treat acid-related diseases worldwide. However, they have a number of limitations including slow onset of action, influence by cytochrome P450 polymorphisms, unsatisfactory effects at night, and instability in acidic conditions. Alternative formulations of conventional PPIs have been developed to overcome these problems; however, these drugs have only introduced small advantages for controlling acid secretion compared to conventional PPIs...
May 9, 2018: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/29730088/aspiration-pneumonia-and-related-syndromes
#14
REVIEW
Augustine S Lee, Jay H Ryu
Aspiration is a syndrome with variable respiratory manifestations that span acute, life-threatening illnesses, such as acute respiratory distress syndrome, to chronic, sometimes insidious, respiratory disorders such as aspiration bronchiolitis. Diagnostic testing is limited by the insensitivity of histologic testing, and although gastric biomarkers for aspiration are increasingly available, none have been clinically validated. The leading mechanism for microaspiration is thought to be gastroesophageal reflux disease, largely driven by the increased prevalence of gastroesophageal reflux across a variety of respiratory disorders, including chronic obstructive pulmonary disease, asthma, idiopathic pulmonary fibrosis, and chronic cough...
May 2, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29729504/new-food-approaches-to-reduce-and-or-eliminate-increased-gastric-acidity-related-to-gastroesophageal-pathologies
#15
Ciro Langella, Daniele Naviglio, Marina Marino, Armando Calogero, Monica Gallo
OBJECTIVE: Gastroesophageal reflux disease is very common in industrialized countries and rapidly and significantly increasing even in developing countries. The approach in this study is one not commonly found to date in the scientific literature. To assess the ability of reduced-carbohydrate diets and foods that are enriched with acid potential of hydrogen (pH; lemon and tomato) to quickly and exponentially reduce symptoms that are related to conditions such as gastritis and gastroesophageal reflux and unrelated to Helicobacter pylori...
March 22, 2018: Nutrition
https://www.readbyqxmd.com/read/29728987/gastrogastric-fistula-an-unusual-cause-for-severe-bile-reflux-following-conversion-of-sleeve-gastrectomy-to-one-anastomosis-gastric-bypass
#16
Ashraf Haddad, Ahmad Bashir, Abdelrahman Nimeri
INTRODUCTION: One anastomosis gastric bypass/mini-gastric bypass (OAGB/MGB) was first described in 2001 as a safe and effective procedure. It has been gaining popularity worldwide. Multiple authors have reported the need to re-operate on patients for bile reflux. We report a patient with severe bile reflux after laparoscopic conversion of sleeve gastrectomy (LSG) to OAGB/MGB. METHODS: A 33-year-old patient underwent a LSG in 2014. Postoperatively, she developed severe gastroesophageal acid reflux...
May 4, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29713813/gastrointestinal-complications-after-lung-transplantation-in-japanese-patients
#17
Hidenao Kayawake, Toyofumi F Chen-Yoshikawa, Hideki Motoyama, Masatsugu Hamaji, Daisuke Nakajima, Akihiro Aoyama, Hiroshi Date
PURPOSE: Gastrointestinal complications after lung transplantation (LTx) are an important postoperative morbidity associated with malnutrition and the malabsorption of drugs. We reviewed our experience of managing gastrointestinal complications after LTx. METHODS: Between June, 2008 and April, 2017, 160 lung transplants were performed at our institution, as living-donor lobar lung transplants in 77 patients, and as deceased-donor lung transplants in 83. We reviewed, retrospectively, the incidence, type and management of gastrointestinal complications...
April 30, 2018: Surgery Today
https://www.readbyqxmd.com/read/29708896/how-the-pathologist-can-aid-in-the-assessment-of-gastroesophageal-reflux-disease
#18
Parakrama Chandrasoma
PURPOSE OF REVIEW: To provide new concepts regarding the early pathologic changes of gastroesophageal reflux disease (GERD) that are associated with damage to the lower esophageal sphincter (LES). RECENT FINDINGS: A body of evidence exists that cardiac mucosa is a metaplastic esophageal epithelium rather than a normal gastric epithelium. Recent studies in asymptomatic volunteers suggest a potential mechanism for cardiac metaplasia in the squamous epithelium of the esophagus...
April 27, 2018: Current Opinion in Gastroenterology
https://www.readbyqxmd.com/read/29705524/factors-related-to-gastric-neuroendocrine-tumors
#19
R Soto-Solís, A F Romano-Munive, K Santana de Anda, R Barreto-Zuñiga
INTRODUCTION AND AIMS: An association between long-term use of proton pump inhibitors and the development of gastric neuroendocrine tumors has been reported, but it is still a subject of debate. The aims of the present study were to determine the presence of this association in a Mexican population and to identify the risk factors for developing gastric neuroendocrine tumors. MATERIALS AND METHODS: A case-control study was conducted, in which the cases were patients with a histopathologic diagnosis of gastric neuroendocrine tumor and the controls were patients evaluated through upper endoscopy...
April 25, 2018: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/29697647/-the-role-of-gastroesophageal-reflux-disease-in-the-development-of-chronic-exudative-otitis-media-in-the-children-during-the-first-year-of-life
#20
I V Rakhmanova, Yu L Soldatsky, A G Matroskin, N S Marenich, V N Shelamova
The objective of the present study was the determination of the incidence of gastroesophageal reflux disease and the evaluation of its possible influence on the development and duration of chronic exudative otitis media in the children during the first year of life. A total of 141 infants at the age of 3 months presenting with exudative otitis media refractory to the conservative treatment throughout the first 1-1.5 months of life were available for the examination. The effectiveness of the anti-reflux therapy was estimated based on the middle ear condition (the presence or absence of exudate) within 3 and 6 months after the initiation of the treatment...
2018: Vestnik Otorinolaringologii
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