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Ocular lymphoma

Shuang Gao, Yingming Zhou, Xiaolong Jin, Zhongjing Lin, Yisheng Zhong, Xi Shen
A 50-year-old woman developed recurrent vitreous opacities in her left eye. The first diagnostic vitrectomy revealed no significant abnormality. OCT showed multiple high-density reflective nodules. The ratio of Interleukin 6 to 10 was over 1 in her aqueous humor, and Epstein-Barr virus was present. Conventional immunohistochemistry examination of vitrectomy specimens was diffusely positive for CD2, CD3, Ki67. Highly-metabolic nodules were found in her right breast on PET-CT scan. Immunohistochemistry of the breast biopsy was suggestive of NK/T cell lymphoma...
October 12, 2018: Survey of Ophthalmology
Lin Zhuang, Jie Lai, Kun Chen, Tianling Ding, Yan Yuan, Yan Ma, Hui Kang, Zhiguang Lin, Ni Fan, Jingjing Ma, Qingchao Zeng, Xiaoping Xu, Qingping Wang, Bobin Chen
The aim of the present study was to prospectively evaluate the recurrence and survival outcome of primary central nervous system lymphoma (PCNSL) with intraocular involvement. For this purpose, a prospective cohort of 103 pathologically confirmed patients with PCNSL was enrolled in this study. Ophthalmologic examinations were performed both at diagnosis and during follow‑up. The patients with PCNSL with suspected intraocular involvement underwent vitrectomy for confirmation. Patients who presented with intraocular involvement either at diagnosis or during disease progression were allocated to the intraocular lymphoma (IOL) group...
October 11, 2018: Oncology Reports
Christos Theophanous, Melike Pekmezci, Bertil E Damato, Andrew A Kao, Michele M Bloomer, Jay M Stewart, Armin R Afshar
Background/Aims: To report the case of a 77-year-old male with a blind, painful eye, referred for suspected corneal mass, with finding of choroidal B-cell lymphoma on pathology of enucleated globe. Methods: This is a retrospective case report of a single patient. Results: A 77-year-old male with a longstanding history of poor vision in the left eye was referred for a scarred, vascularized corneal mass. The patient had reported occasional mild ocular discomfort in the left eye and loss of light perception over the last year...
September 2018: Ocular Oncology and Pathology
Niharika Singh, Ian Chin, Paul Gabriel, Emily Blaum, Sharmila Masli
The risk of developing lymphoma in patients with Sjögren's syndrome (SS) is 44 times higher than in the normal population with the most common lymphomas derived from marginal zone B (MZB) cells. Current understanding of the role of MZB cells in SS is primarily based on salivary gland pathology, while their contextual association with lacrimal glands and ocular manifestations largely remains unknown. We examined this possibility using a SS mouse model (thrombospondin-1 deficient (TSP1-/- )) with well-characterized ocular disease...
October 11, 2018: International Journal of Molecular Sciences
Shi Zhuan Tan, Laura R Steeples, Ramandeep Chhabra, Nicholas P Jones
BACKGROUND: Primary vitreoretinal lymphoma (PVRL) is a rare ocular condition and its diagnosis remains a challenge. The clinical presentation is variable and it can masquerade as chronic intermediate or posterior uveitis. We report an unusual case of primary central nervous system lymphoma (PCNSL) presenting as migrating retinal lesions with unique shapes. The diagnostic challenges are described and the clinical features of intraocular lymphoma are reviewed. CASE PRESENTATION: A 53 year-old gentleman presented with unilateral visual disturbance and a wide area of retinal whitening with sharp borders temporal to the macula, corresponding to hyper-reflective subretinal changes on optical coherence tomography (OCT)...
September 14, 2018: BMC Ophthalmology
Hayyam Kiratli, Figen B Aygün, Gökhan Gedikoğlu
PURPOSE: To report a patient who developed unilateral corneal stromal infiltration while undergoing systemic chemotherapy for multinodal peripheral T-cell lymphoma not otherwise specified. METHODS: Clinical, imaging, and immunohistopathological features of a 40-year-old woman who presented with a stromal haze in the right cornea were reviewed. RESULTS: At initial presentation, her visual acuity in the right eye was 20/40. Slit-lamp examination showed stromal infiltration located mainly in the inferotemporal peripheral cornea without epithelial or limbal involvement...
September 14, 2018: Cornea
Hyunchul Jung, Hae Yong Yoo, Seung Ho Lee, Sohyun Shin, Sang Cheol Kim, Sejoon Lee, Je-Gun Joung, Jae-Yong Nam, Daeun Ryu, Jae Won Yun, Jung Kyoon Choi, Ambarnil Ghosh, Kyeong Kyu Kim, Seok Jin Kim, Won Seog Kim, Woong-Yang Park, Young Hyeh Ko
[This corrects the article DOI: 10.18632/oncotarget.14928.].
August 28, 2018: Oncotarget
Pranita Sahay, Prafulla Kumar Maharana, Shreyas Temkar, Rohan Chawla
A 49-year-old woman, known case of diffuse large B-cell lymphoma, presented with complaints of floater in both eyes since 3 days. On examination, visual acuity was 0.18 logMAR in both eyes. Indirect ophthalmoscopy revealed presence of vitreous clumps. Vitreous biopsy was done and the histopathological report suggested a diagnosis of ocular lymphoma. The patient was treated with weekly injections of intravitreal methotrexate in both eyes. The patient developed severe photophobia, watering, redness and diminution of vision in the both eyes 2 days following the fifth dose of intravitreal methotrexate...
August 27, 2018: BMJ Case Reports
Tine Gadegaard Olsen, Steffen Heegaard
Orbital lymphomas constitute 50-60% of ocular adnexal lymphomas. A total of 2211 cases of orbital lymphoma with a known subtype have been reported in the last 24 years (1994-2017). The vast majority of orbital lymphomas are of B-cell origin (97%), of which extranodal marginal zone B-cell lymphoma (EMZL) (59%) is the most common subtype, followed by diffuse large B-cell lymphoma (23%), follicular lymphoma (9%), and mantle cell lymphoma (5%). Orbital lymphoma is primarily a disease of the elderly. Gender distribution varies according to lymphoma subtype...
August 23, 2018: Survey of Ophthalmology
Oded Sagiv, Sudip D Thakar, John T Manning, Thomas J Kandl, Luis E Fayad, Nathan Fowler, Fredrick B Hagemeister, Michelle A Fanale, Chelsea C Pinnix, Felipe Samaniego, Bita Esmaeli
PURPOSE: The authors examined the prevalence of a histologic change of ocular adnexal lymphoma (OAL) grade in patients with a history of lymphoma in nonocular sites. METHODS: In this retrospective study, the authors reviewed the clinical and pathological data of 209 patients with OAL treated by the senior author during 2000 to 2017. RESULTS: Of 209 patients with OAL, 65 (31%) had a history of lymphoma. In 54 of the 65 patients (83%), the original lymphoma and OAL were of the same histologic type...
August 17, 2018: Ophthalmic Plastic and Reconstructive Surgery
Clemens Alexander Klaus Lange, Patrick Lehnert, Stefaniya Konstantinova Boneva, Peipei Zhang, Franziska Ludwig, Martin Boeker, Klaus Hoffmeier, Ralf Horres, Günther Schlunck, Thomas Reinhard, Daniel Böhringer, Claudia Auw-Haedrich
PURPOSE: To investigate the expression profile of the hypoxia-inducible transcription factor-1α (HIF-1α) and its downstream targets in malignancies of the ocular adnexa and to determine its relevance as a prognostic factor for clinical outcome. METHODS: We included 49 subjects with malignant tumours (25 squamous cell carcinomas (SCC), 15 non-Hodgkin lymphomas, 9 melanomas) and 30 patients with benign tumours of the ocular adnexa (13 papillomas, 7 reactive lymphoid hyperplasias (RLHs) and 10 nevi) as controls...
July 31, 2018: Eye
Rim Batti, Feryel Letaief, Haifa Rachdi, Asma Zidi, Sonia Sghaier, Mouna Ayadi, Khadija Meddeb, Amina Mokrani, Yosra Yahyaoui, Henda Raies, Nesrine Chraiet, Amel Mezlini
Primary lung lymphomas are rare tumors representing less than 1% of malignant tumors of the lung. The most frequent form is the mucosa-associated lymphoid tissue (MALT). Ocular involvement is also rare and it is mostly located in the lachrymal glands. We report the case of a patient with pulmonary MALT lymphoma associated with synchronous involvement of the lachrymal glands. This study illustrates the nonspecific clinical, radiological and evolutionary features of this disease.
2018: Pan African Medical Journal
Wataru Yamada, Hiroki Yamada, Kazuhiro Murata, Hiroshi Kosugi, Yuko Asano, Kiyofumi Mochizuki, Kyoko Ishida
A rare case of 70-year-old woman with adult T-cell leukemia/lymphoma who developed multifocal choroiditis from a dissemination of Cryptococcus neoformans is reported. Ophthalmologic examination revealed multiple yellowish choroidal lesions in the posterior pole of both eyes. Sequential optical coherence tomographic images disclosed the involvement of the choroid and the consecutive changes in its architecture during the course of treatment. The recognition of these ocular manifestations may be important for the rapid diagnosis of C...
July 26, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
Ahmet Kaan Gündüz, Yağmur Seda Yeşiltaş, Carol L Shields
PURPOSE OF REVIEW: The goal of this article is to review the key clinical and radiological features, treatment strategies, and prognosis of lacrimal gland tumors. RECENT FINDINGS: Debulking of the orbital lobe of the lacrimal gland may offer improved control rates in dacryoadenitis without compromise of tear film function. Contrary to previous belief, careful biopsy of the lacrimal gland prior to excision does not appear to increase the risk of recurrence in cases with suspected pleomorphic adenoma...
September 2018: Current Opinion in Ophthalmology
Laura S Hiemcke-Jiwa, Ninette H Ten Dam-van Loon, Roos J Leguit, Stefan Nierkens, Jeannette Ossewaarde-van Norel, Joke H de Boer, Floor F Roholl, Roel A de Weger, Manon M H Huibers, Jolanda D F de Groot-Mijnes, Jonas J W Kuiper
Importance: The diagnostic workup of patients suspected of having vitreoretinal lymphoma (VRL) is primarily based on vitreous fluid analysis, including the recently emerging myeloid differentiation primary response gene 88 (MYD88) mutation analysis. Aqueous humor paracentesis is a relatively less invasive and safer procedure than taking vitreous fluid specimens, and aqueous humor-based MYD88 mutation analysis would provide an additional liquid biopsy tool to diagnose and monitor patients with VRL...
October 1, 2018: JAMA Ophthalmology
Gábor G Deák, Scott R Sneed, Lee M Jampol
PURPOSE: To present a rare case of primary vitreoretinal lymphoma presenting with cystoid macular edema without previous surgical intervention or radiotherapy. METHODS: Retrospective chart review of one patient. RESULTS: A 74-year-old patient was seen with a history of cataract surgery in 1 eye and presumed ocular inflammation with recurrent cystoid macular edema in both eyes. On examination, subretinal pigment epithelial and intraretinal infiltrates raised the suspicion of primary vitreoretinal lymphoma despite the unusual presentation with cystoid macular edema...
July 13, 2018: Retinal Cases & Brief Reports
Caleb Busch, Noriyasu Hashida, Kohji Nishida
Purpose: To report a case of corneal infiltration and xanthoma formation in mycosis fungoides (cutaneous T-cell lymphoma). Observations: A middle aged Japanese man with mycosis fungoides (MF) involving the face was referred to Ophthalmology for evaluation of unilateral, painless conjunctival injection. Biopsy of the conjunctiva revealed a malignant T cell population consistent with MF tumor invasion. Years later, he returned following several episodes of infectious keratitis with a painless, yellow, rapidly forming mass in the left eye over two weeks...
September 2018: American Journal of Ophthalmology Case Reports
Arisa Okada, Yosuke Harada, Tomoko Inoue, Yoshiko Okikawa, Tatsuo Ichinohe, Yoshiaki Kiuchi
Purpose: To report a rare case of primary orbital natural killer (NK)/T-cell lymphoma without nasal lesions but with cerebrospinal fluid involvement. Observations: A 73-year-old woman was referred to the uveitis clinic with suspected unilateral acute uveitis in her right eye and a right orbital tumor. Epstein-Barr virus DNA was detected in the aqueous humor in her right eye, and orbital biopsy revealed the presence of extranodal NK/T-cell lymphoma (ENKTL), nasal type...
September 2018: American Journal of Ophthalmology Case Reports
Sung Yong Oh, Won Seog Kim, Hye-Jin Kang, Ji Hyun Lee, Seok Jae Huh, Seok Jin Kim, Dok Hyun Yoon, Jung Yong Hong, Won Sik Lee, Hyo Jung Kim, Jong Ho Won, Byeong-Bae Park, Soon Ii Lee, Cheolwon Suh
Both-side synchronous involvement has been reported to account for 7-24% of ocular adnexal marginal zone lymphoma (OAML). We conducted a retrospective analysis to identify the clinical features and treatment outcomes of synchronous bilateral OAML (SB-OAML) by treatment modality. We analyzed patients with a histologic diagnosis of SB-OAML, excluding metachronous bilateral involved OAML. We enrolled a total of 95 patients for this analysis, 36 males and 59 females; the median patient age was 42 years (range 16-77 years)...
October 2018: Annals of Hematology
Akihisa Suwa, Tetsuya Shimoda
Hemophagocytic syndrome (HPS) is a clinicopathological entity characterized by histiocytic proliferation, with marked hemophagocytosis in the reticuloendothelial organs. HPS caused by lymphoma is termed lymphoma-associated hemophagocytic syndrome (LAHS), and there are few reports on canine and feline LAHS. The objective of this study was to examine the clinical, diagnostic, and clinicopathologic features of LAHS in six dogs. The diagnostic criteria of LAHS consisted of lymphoma, bicytopenia or pancytopenia in the blood, and increased hemophagocytosis in the reticuloendothelial organs...
August 22, 2018: Journal of Veterinary Medical Science
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