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Ocular lymphoma

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https://www.readbyqxmd.com/read/28203686/ocular-involvement-of-multicentric-malignant-b-cell-lymphoma-in-a-ewe-a-case-report
#1
James O Rushton, Denise Thaller, Reinhild Krametter-Froetscher
An 8.5-year-old, 98 kg female mountain sheep presented with bilateral exophthalmos with reduced retropulsion of the globes, impairing physiologic eyelid closure, sanguineous ocular discharge, as well as swelling of the eyelids and periocular skin. Bilateral vitreal hemorrhage hindering examination of the fundus was further noticed. Systemic signs included reduced general demeanour, presence of a firm mass in the left half of the mammary gland, multiple masses in the area of the vulva and a mass between the shoulder blades...
February 16, 2017: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/28152507/the-mutational-landscape-of-ocular-marginal-zone-lymphoma-identifies-frequent-alterations-in-tnfaip3-followed-by-mutations-in-tbl1xr1-and-crebbp
#2
Hyunchul Jung, Hae Yong Yoo, Seung Ho Lee, Sohyun Shin, Sang Cheol Kim, Sejoon Lee, Je-Gun Joung, Jae-Yong Nam, Daeun Ryu, Jae Won Yun, Jung Kyoon Choi, Ambarnil Ghosh, Kyeong Kyu Kim, Seok Jin Kim, Won Seog Kim, Woong-Yang Park, Young Hyeh Ko
Ocular marginal zone lymphoma is a common type of low-grade B-cell lymphoma. To investigate the genomic changes that occur in ocular marginal zone lymphoma, we analyzed 10 cases of ocular marginal zone lymphoma using whole-genome and RNA sequencing and an additional 38 cases using targeted sequencing. Major genetic alterations affecting genes involved in nuclear factor (NF)-κB pathway activation (60%), chromatin modification and transcriptional regulation (44%), and B-cell differentiation (23%) were identified...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/28145942/clinical-pathologic-correlation-of-sarcoidosis-associated-multifocal-chorioretinitis-in-an-elderly-patient
#3
Mohamed G A Saleh, John L OʼDonnell, Ronald P Davis, David Wilson, Phoebe Lin
BACKGROUND/PURPOSE: To describe a case of histopathologic clinical correlation of sarcoidosis-related multifocal chorioretinitis in an elderly individual. METHODS: This is a single case report and review of the pertinent literature. A 72-year-old white woman with a history of asthma was referred with bilateral asymmetric low-grade chronic panuveitis with advancing peripheral punched-out chorioretinal lesions despite systemic corticosteroid treatment. RESULTS: Coalescent chorioretinal punched-out lesions on fundus examination in the more severely affected right eye did not respond to corticosteroid treatment, and the refractory nature resulted in a suspicion of intraocular lymphoma despite a previous inconclusive diagnostic vitrectomy result...
January 31, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28135745/-diagnostic-management-of-exophthalmos
#4
A Klingenstein, C Hintschich
Exophthalmos is a common and important symptom in orbital consultation. It can be either uni- or bilateral. A wide spectrum of benign and malignant diseases has to be considered and evaluated for differential diagnosis, in order to maintain complete ocular function and to lead the patient to adequate therapy. Exophthalmos can be accompanied by variable symptoms, ranging from neurogenic or myogenic to corneal alterations. Symptoms at presentation depend on the underlying disease and may manifest systemically...
January 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28128370/an-ocular-protein-triad-can-classify-four-complex-retinal-diseases
#5
J J W Kuiper, L Beretta, S Nierkens, R van Leeuwen, N H Ten Dam-van Loon, J Ossewaarde-van Norel, M C Bartels, J D F de Groot-Mijnes, P Schellekens, J H de Boer, T R D J Radstake
Retinal diseases generally are vision-threatening conditions that warrant appropriate clinical decision-making which currently solely dependents upon extensive clinical screening by specialized ophthalmologists. In the era where molecular assessment has improved dramatically, we aimed at the identification of biomarkers in 175 ocular fluids to classify four archetypical ocular conditions affecting the retina (age-related macular degeneration, idiopathic non-infectious uveitis, primary vitreoretinal lymphoma, and rhegmatogenous retinal detachment) with one single test...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28125759/clinical-features-differentiating-benign-from-malignant-conjunctival-tumors-in-children
#6
Carol L Shields, Kareem Sioufi, Adel E Alset, Nina S Boal, Mairghread G Casey, Austen N Knapp, Jordan A Sugarman, Marisa A Schoen, Phillip S Gordon, Emil Anthony T Say, Jerry A Shields
Importance: Conjunctival tumors in children are usually benign and rarely malignant. Objective: To evaluate clinical features of conjunctival tumors in children by comparing benign tumors with their malignant counterparts. Design, Setting, and Participants: This retrospective case series reviewed 806 cases of conjunctival tumor in children (aged <21 years) who were evaluated at a tertiary referral center between November 1, 1975, and July 1, 2015...
January 26, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28099084/mechanisms-and-new-strategies-for-primary-sj%C3%A3-gren-s-syndrome
#7
Clio P Mavragani
Primary Sjögren's syndrome (SS) is a common chronic autoimmune disease characterized by lymphocytic infiltration of exocrine glands, mainly salivary and lacrimal, resulting in oral and ocular dryness, although virtually any organ system can be affected. SS-related systemic manifestations are classified as either related to the presence of periepithelial infiltrates in exocrine and parenchymal organs or resulting from immunocomplex deposition due to B cell hyperactivity with increased risk for B cell lymphoma development...
January 14, 2017: Annual Review of Medicine
https://www.readbyqxmd.com/read/28058157/unilateral-recurrent-anterior-uveitis-as-the-presenting-sign-of-bladder-carcinoma
#8
Günhal Şatırtav, Meryem Donbaloğlu, Refik Oltulu, Pembe Oltulu, Hürkan Kerimoğlu, Ahmet Özkağnıcı
A 79-year-old male patient was followed for unilateral uveitis with 3 attacks in 10 months, despite initial improvement with steroid therapy. The patient had visual acuity (VA) of counting fingers in right eye, hypopyon and vitritis with no chorioretinal lesions. The left eye was normal. The patient was evaluated for intraocular foreign body, intraocular lymphoma and associated systemic disease and malignancy. Computed tomography of the abdomen showed a mass in the bladder. Biopsy confirmed bladder carcinoma...
August 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28048695/su-f-t-86-electron-dosimetric-effects-of-bolus-and-lens-shielding-in-treating-superficial-eye-lesions
#9
L Young, L Wootton, O Gopan, J Liao
PURPOSE: Electron therapy for the treatment of ocular lymphomas requires the lens to be shielded to prevent secondary cataracts. This work evaluates the dosimetry under a suspended eyeshield with and without bolus for low energy electron fields. METHODS: Film (GafChromic EBT3) dosimetry and relative output factors were measured for 6, 8, and 10 MeV electron energies. A customized 5 cm diameter circle electron orbital cutout was constructed for a 6×6 cm applicator with a lens shield, 1 cm diameter Cerrobend cylinder with 2...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28003984/incidence-of-orbital-conjunctival-and-lacrimal-gland-malignant-tumors-in-usa-from-surveillance-epidemiology-and-end-results-1973-2009
#10
Waleed M Hassan, Mohamed S Bakry, Housam M Hassan, Ahmad S Alfaar
AIM: To determine the types and incidence of tumors affecting the orbit, conjunctiva and lacrimal glands and to study the trend line of these tumors in the United States from 1973 to 2009. METHODS: We used the publicly available Surveillance, Epidemiology and End Results (SEER) database registries to determine the incidence rates. Age was adjusted to the 2000 US Standard Population. Patients were stratified according to age group, gender, race and histological grouping of tumor lesions...
2016: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28002793/next-generation-sequencing-of-vitreoretinal-lymphomas-from-small-volume-intraocular-liquid-biopsies-new-routes-to-targeted-therapies
#11
Andi K Cani, Daniel H Hovelson, Hakan Demirci, Mark W Johnson, Scott A Tomlins, Rajesh C Rao
BACKGROUND: Vitreoretinal lymphoma (VRL), the most common lymphoma of the eye, is a rare form of primary CNS lymphoma (PCNSL). Most frequently a high-grade diffuse large B cell lymphoma, VRL can cause vision loss and its prognosis remains dismal: the overall survival time is 3 years after diagnosis. Radiotherapy and chemotherapy are used but remain frequently ineffective, and no standardized treatment regimen exists. Furthermore, no biologically targeted treatments, based on the genetic profile of the tumor, are available, as VRL has hitherto not comprehensively been profiled...
January 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/27986437/intralesional-rituximab-in-primary-conjunctival-follicular-lymphoma-relapsed
#12
S Rodríguez Villa, M J Ruiz Rodríguez, M Vargas Pabón
CLINICAL CASE: A 49-year-old woman experienced a local relapse of a primary follicular lymphoma (FL) of the conjunctiva. She received 4 weekly intra-lesional injections followed by 6 monthly injections of rituximab (6mg/ml). A clinical response was achieved after first injection. No adverse ocular event or signs of lymphoma relapse were seen after 10 months of follow-up. DISCUSSION: Intralesional administration of rituximab for treating primary FL of the conjunctiva was an effective and safe therapeutic option; therefore it could be an alternative to other conventional treatments, such as radiotherapy or chemotherapy...
December 13, 2016: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/27934561/various-regimens-of-total-body-irradiation-for-hematopoietic-stem-cell-transplant
#13
Naoya Ishibashi, Toshiya Maebayashi, Takuya Aizawa, Masakuni Sakaguchi, Osamu Abe, Kazuyoshi Sakanishi, Yuji Endoh, Tsutomu Saito, Jiro Kawamori, Yoshiaki Tanaka
OBJECTIVES: We aimed to evaluate the safety of total body irradiation before bone marrow transplant. MATERIALS AND METHODS: We analyzed 110 patients (65 male, 45 female) who underwent total body irradiation for hematopoietic stem cell transplant between May 1998 and March 2013. Median age at total body irradiation was 17 years (range, 1-62 y). Median observation time was 777 days (range, 31-5494 d). Initial diagnoses were acute lymphoblastic leukemia (24 patients), acute myeloid leukemia (26 patients), chronic myeloid leukemia (7 patients), myelodysplastic syndrome (8 patients), malignant lymphoma (13 patients), mucopolysaccharidosis (12 patients), neuroblastoma (10 patients), and other diseases (10 patients)...
December 2016: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/27902909/marek-s-disease-in-backyard-chickens-a-study-of-pathologic-findings-and-viral-loads-in-tumorous-and-nontumorous-birds
#14
Aslı Mete, Radhika Gharpure, Maurice E Pitesky, Dan Famini, Karen Sverlow, John Dunn
Marek's disease (MD) is a major cause of mortality in backyard chickens. The diagnosis of MD is complex, however, and knowledge of Marek's disease virus (MDV) in spontaneous field cases such as in backyard chickens is largely unknown. In this study, 40 backyard chickens with a presumptive MD diagnosis based on histologic lymphoid infiltrations in peripheral nerves with and without lymphomas were investigated. Twenty-eight of the birds were submitted to the diagnostic laboratory for disease explorations, and 12 chickens were from a flock in which some members demonstrated anisocoria and pupil irregularities compatible with ocular MD...
December 2016: Avian Diseases
https://www.readbyqxmd.com/read/27894880/lymphoma-of-the-eyelid
#15
REVIEW
Frederik Holm Svendsen, Steffen Heegaard
Lymphoma of the eyelid constitutes 5% of ocular adnexal lymphoma. In previously published cases, 56% of lymphomas of the eyelid are of B-cell origin and 44% are of T-cell origin. The most frequent B-cell lymphomas are extranodal marginal zone lymphoma (27 cases-14%) and diffuse large B-cell lymphoma (18 cases-9%). T-cell lymphomas are most frequently mycosis fungoides (25 cases-13%), extranodal natural killer/T-cell, nasal-type lymphoma (12 cases-6%), and primary cutaneous anaplastic large-cell lymphoma (12 cases-6%)...
November 26, 2016: Survey of Ophthalmology
https://www.readbyqxmd.com/read/27882744/transpalpebral-exenteration-in-cattle-a-retrospective-study-of-115-cases
#16
Munashe Chigerwe, John A Angelos, Lisa Gamsjäeger, Meera C Heller
OBJECTIVE: To describe the indications for exenteration and complications associated with the procedure. ANIMALS STUDIED: 115 cattle. PROCEDURES: Medical records of cattle presented for unilateral exenteration evaluated at the University of California, Davis Veterinary Medical Teaching Hospital from January 1985 through December 2015 were reviewed. RESULTS: Median (range) age at presentation for all cattle was 6 (0.2-30) years...
November 24, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/27868373/acute-myeloid-leukemia-in-baraitser-winter-cerebrofrontofacial-syndrome
#17
Paola Cianci, Grazia Fazio, Sara Casagranda, Marco Spinelli, Carmelo Rizzari, Gianni Cazzaniga, Angelo Selicorni
Baraitser-Winter malformation syndrome (BWMS), Fryns-Aftimos syndrome (FA), and craniofrontofacial syndromes (CFFs) have all been recently proposed to be part of the same phenotypic spectrum of Baraitser-Winter cerebrofrontofacial syndrome (BWCFF), which is characterized by facial dysmorphism, ocular coloboma, brain malformations, and intellectual disabilities. In addition to that, the recent discovery of missense mutations in one of the two ubiquitously expressed cytoplasmic β- and γ-acting-encoding genes ACTB (7p22...
February 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27843901/anterior-chamber-non-hodgkin-lymphoma-of-the-iris-masquerading-as-uveitis-glaucoma-hyphema-syndrome
#18
Angela C Gauthier, Alexander Nguyen, William R Munday, Mina L Xu, Miguel A Materin
PURPOSE: To report a case of iris non-Hodgkin lymphoma initially thought to be uveitis-glaucoma-hyphema (UGH) syndrome. METHODS: We reviewed the clinical, radiographic, and histopathologic findings in a patient with recurrent hyphemas and increased ocular pressure who eventually was found to have a rapidly growing iris mass. RESULTS: An 89-year-old man with a history of cataract extraction and mantle cell lymphoma developed recurrent hyphema, which was subsequently revealed to be due to an iris mass...
October 2016: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/27830722/comprehensive-polymerase-chain-reaction-assay-for-detection-of-pathogenic-dna-in-lymphoproliferative-disorders-of-the-ocular-adnexa
#19
Yoshihiko Usui, Narsing A Rao, Hiroshi Takase, Kinya Tsubota, Kazuhiko Umazume, Daniel Diaz-Aguilar, Takeshi Kezuka, Manabu Mochizuki, Hiroshi Goto, Sunao Sugita
Infectious agents have been identified as a major cause of specific types of human cancers worldwide. Several microorganisms have been identified as potential aggravators of ocular adnexal neoplasms; however, given the rarity of these neoplasms, large epidemiological studies are difficult to coordinate. This study aimed to conduct an exhaustive search for pathogenic DNA in lymphoproliferative disorders (LPD) of the ocular adnexa in a total of 70 patients who were diagnosed with LPD of the ocular adnexa between 2008 and 2013...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27793489/eyelid-lymphoma-in-a-patient-with-a-gold-weight-implant
#20
L A Di Nisio, J O Croxatto, M C Mansur, J P Aldecoa, D Weil
CASE REPORT: A male patient with an exposure keratopathy caused by lagophthalmos. A gold weight was implanted in the right upper eyelid. Eight months later, he presented with erythema and swelling of right upper eyelid. An incisional biopsy was performed, reporting extranodal marginal zone B cell lymphoma. DISCUSSION: when a tumour at the site of a gold weight implant is refractory to treatment, it is essential to perform an incisional biopsy to establish the histopathological diagnosis...
October 25, 2016: Archivos de la Sociedad Española de Oftalmología
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