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bdnf, boswellia

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https://www.readbyqxmd.com/read/27966331/boswellia-serrata-gum-resin-aqueous-extract-upregulatesbdnf-but-not-creb-expression-in-adult-male-rat-hippocampus
#1
Mohammad Khalaj-Kondori, Farzaneh Sadeghi, Mohammad Ali Hosseinpourfeizi, Farzam Shaikhzadeh-Hesari, Aylar Nakhlband, Mohammad Rahmati-Yamchi
BACKGROUND/AIM: Boswellia from the family Burseraceae has been proposed for prevention of amnesia; however, the molecular mechanism by which it affects memory is not clear. To reveal the potential molecular mechanism, the effects of boswellia on the expression of two memory related genes, CREB and BDNF, were investigated. MATERIALS AND METHODS: Twenty-one male rats were randomly divided into 3 groups (n = 7): the control group received distilled water and the treatment groups received two doses of aqueous extract of Boswellia serrata gum resin (boswellia) (50 and 100 mg/kg) every day for 4 weeks...
November 17, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/23015543/incensole-acetate-reduces-depressive-like-behavior-and-modulates-hippocampal-bdnf-and-crf-expression-of-submissive-animals
#2
Arieh Moussaieff, Moshe Gross, Elimelech Nesher, Tatiana Tikhonov, Gal Yadid, Albert Pinhasov
Incensole acetate (IA), a constituent of Boswellia resin ('frankincense'), was previously demonstrated to exhibit an antidepressive-like effect in the Forced Swim Test (FST) in mice following single dose administration (50 mg/kg). Here, we show that acute administration of considerably lower dose (10 mg/kg) IA to selectively bred mice, showing prominent submissive behavior, exerted significant antidepressant-like effects in the FST. Furthermore, chronic administration of 1 or 5 mg/kg per day of IA for three consecutive weeks dose- and time-dependently reduced the submissiveness of the mice in the Dominant-Submissive Relationship test, developed to screen the chronic effect of antidepressants...
December 2012: Journal of Psychopharmacology
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