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Early Life Stress

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https://www.readbyqxmd.com/read/29044990/transcriptome-analysis-for-uvb-induced-phototoxicity-in-mouse-retina
#1
Mi-Jin An, Chul-Hong Kim, Gyu-You Nam, Dae-Hyun Kim, Sangmyung Rhee, Sung-Jin Cho, Jung-Woong Kim
Throughout life, the human eye is continuously exposed to sunlight and artificial lighting. Ambient light exposure can lead to visual impairment and transient or permanent blindness. To mimic benign light stress conditions, Mus musculus eyes were exposed to low-energy UVB radiation, ensuring no severe morphological changes in the retinal structure post-exposure. We performed RNA-seq analysis to reveal the early transcriptional changes and key molecular pathways involved before the activation of the canonical cell death pathway...
October 17, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29043596/short-term-prospective-questionnaire-study-of-early-postoperative-quality-of-life-after-colorectal-endoscopic-submucosal-dissection
#2
Fumihiko Nakamura, Yutaka Saito, Shin Haruyama, Masau Sekiguchi, Masayoshi Yamada, Taku Sakamoto, Takeshi Nakajima, Seiichiro Yamamoto, Yoshitaka Murakami, Hideki Ishikawa, Takahisa Matsuda
BACKGROUND: Endoscopic submucosal dissection (ESD) has become popular as an alternative to laparoscopy-assisted colectomy (LAC) for early colorectal cancer. AIM: To validate postoperative quality of life (QOL) based on subjective symptoms of patients from questionnaire survey. METHODS: We prospectively enrolled patients planned to undergo ESD for adenoma or Tis/T1a cancer at our institution between December 2011 and January 2013. Controls were prospectively enrolled LAC patients diagnosed with T1b cancer...
October 17, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/29042878/the-evaluation-acute-traumatic-stress-level-in-close-relatives-of-stroke-patients
#3
Yasemin Ünal, Yes Im Ünal, Dilek A Öztürk, Gülser K Emir, Mustafa Yılmaz, Gulnihal Kutlu
OBJECTIVE: Stroke is the second most common cause of death and the leading cause of adult disability. Both stroke patients and their family can therefore experience increased traumatic stress level. METHODS: The participants are close relatives of patients (n=65) who had a first time stroke (CRPWS) hospitalized. A control group (CG) (n=61), who had no history of chronic illness in their family and had at least one traumatic life event experience. The National Institutes of Health Stroke Scale, Modified Rankin Scale, Personal Information Form, Life Events Checklist, Traumatic Stress Symptom Scale, and Multidimensional Scale of Perceived Social Support, were used in the study...
September 2017: Psychiatry Investigation
https://www.readbyqxmd.com/read/29042485/maternal-stress-during-pregnancy-and-allergic-diseases-in-children-during-the-first-year-of-life
#4
Katarzyna Smejda, Kinga Polanska, Dorota Merecz-Kot, Anna Krol, Wojciech Hanke, Joanna Jerzynska, Wlodzimierz Stelmach, Paweł Majak, Iwona Stelmach
BACKGROUND: Many recent studies indicate that prenatal maternal distress increases the risk of allergic diseases in children. The mechanisms that favor it are still unclear. OBJECTIVES: We aimed to assess the association between exposure to different kinds of prenatal stress and the occurrence of atopic dermatitis, food allergy, wheezing, and recurrent respiratory tract infections in children. METHODS: The study population consisted of 370 mother-child pairs from a Polish Mother and Child Cohort (REPRO_PL)...
October 17, 2017: Respiratory Care
https://www.readbyqxmd.com/read/29041860/maternal-behavior-of-the-mouse-dam-toward-pups-implications-for-maternal-separation-model-of-early-life-stress
#5
Rodrigo Orso, Luis Eduardo Wearick-Silva, Kerstin Camile Creutzberg, Anderson Centeno-Silva, Laura Glusman Roithmann, Rafaelly Pazzin, Saulo Gantes Tractenberg, Fernando Benetti, Rodrigo Grassi-Oliveira
Maternal care is essential for an adequate pup development, as well as for the health of the dam. Exposure to stress in early stages of life can disrupt this dam-pup relationship promoting altered neurobiological and behavioral phenotypes. However, there is a lack of consensus regarding the effects of daily maternal separation (MS) on the pattern of maternal behavior. The aim of this study is to compare the patterns of maternal behavior between mice exposed to MS and controls. BALB/c mice were subjected to MS for a period of 180 min/day from postnatal day 2-7 (n = 17) or designated to be standard animal facility reared (AFR) controls (n = 19)...
October 18, 2017: Stress: the International Journal on the Biology of Stress
https://www.readbyqxmd.com/read/29040815/the-role-of-folic-acid-and-selenium-against-oxidative-ethanol-damage-in-early-life-programming-a-review
#6
Mª Luisa Ojeda Murillo, Fatima Nogales Bueno, Mª Luisa Murillo Taravillo, Olimpia Carreras Sánchez
Several disorders in children, called Fetal Alcohol Spectrum Disorders (FASD), occur as result of alcohol consumption during pregnancy and lactation. They appear, at least in part, to be related to the oxidative stress that this drug generates. Ethanol metabolism generates reactive oxygen species and causes a depletion of the antioxidant molecule glutathione (GSH) leading to oxidative stress and lipid and protein damage which are related to growth retardation and neurotoxicity, increasing the incidence of FASD...
October 17, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29039684/parenting-stress-in-parents-of-infants-with-congenital-heart-disease-and-parents-of-healthy-infants-the-first-year-of-life
#7
Nadya Golfenshtein, Alexandra L Hanlon, Janet A Deatrick, Barbara Medoff-Cooper
While we know that the parents of infants with congenital heart disease (CHD), the most prevalent group of congenital anomalies, experience increased parenting stress, the stress levels throughout infancy have yet to be studied. Stress experienced by parents beyond the normative stress of parenting can interfere with parenting processes, and bear adverse family outcomes. This prospective cohort study was conducted to describe and compare parenting stress levels during infancy between parents of infants with complex CHD and parents of healthy infants...
October 17, 2017: Compr Child Adolesc Nurs
https://www.readbyqxmd.com/read/29039414/-the-limbic-system-in-youth-depression-brain-structural-and-functional-alterations-in-adolescent-in-patients-with-severe-depression
#8
Ronny Redlich, Nils Opel, Christian Bürger, Katharina Dohm, Dominik Grotegerd, Katharina Förster, Dario Zaremba, Susanne Meinert, Jonathan Repple, Verena Enneking, Elisabeth Leehr, Joshua Böhnlein, Lena Winters, Neele Froböse, Sophia Thrun, Julia Emtmann, Walter Heindel, Harald Kugel, Volker Arolt, Georg Romer, Christian Postert, Udo Dannlowski
Adolescent-onset Major Depressive Disorder (MDD) is associated with an increased risk of recurrent depressive episodes, suicidal behaviors, and psychiatric morbidity throughout the lifespan. The objective of the present study was to investigate brain structural and functional changes in adolescent patients with MDD. Furthermore, we aimed to clarify the influence of early-life stress on brain function and structure. The study investigated adolescent patients with severe MDD (n=20, mean age=16.0, range=15-18 years) and a control sample of matched healthy adolescents (n=21, mean age= 16...
October 17, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29035709/heart-rate-variability-and-salivary-cortisol-in-very-preterm-children-during-school-age
#9
Natalie Urfer-Maurer, Sebastian Ludyga, Tobias Stalder, Serge Brand, Edith Holsboer-Trachsler, Markus Gerber, Alexander Grob, Peter Weber, Sakari Lemola
The autonomic nervous system (ANS) plays a major role in the human stress response and reflects physical and psychological adaptability to a changing environment. Long-term exposure to early life stressors may alter the function of the ANS. The present study examines differences in the ANS between children born very preterm and full-term as well as the association between the ANS and the hypothalamic-pituitary-adrenal (HPA) axis, the other main branch of the human stress system. Fifty-four healthy children born very preterm (<32nd gestational week) and 67 full-term children aged 7-12 years provided data for the present study...
October 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29033027/anhedonia-following-early-life-adversity-involves-aberrant-interaction-of-reward-and-anxiety-circuits-and-is-reversed-by-partial-silencing-of-amygdala-corticotropin-releasing-hormone-gene
#10
Jessica L Bolton, Jenny Molet, Limor Regev, Yuncai Chen, Neggy Rismanchi, Elizabeth Haddad, Derek Z Yang, Andre Obenaus, Tallie Z Baram
BACKGROUND: Anhedonia, the diminished ability to experience pleasure, is an important dimensional entity linked to depression, schizophrenia, and other emotional disorders, but its origins and mechanisms are poorly understood. We have previously identified anhedonia, manifest as decreased sucrose preference and social play, in adolescent male rats that experienced chronic early-life adversity/stress (CES). Here we probed the molecular, cellular, and circuit processes underlying CES-induced anhedonia and tested them mechanistically...
September 7, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/29032166/interpersonal-vulnerability-among-offspring-of-holocaust-survivors-gay-men-and-its-association-with-depressive-symptoms-and-life-satisfaction
#11
Geva Shenkman, Amit Shrira, Kfir Ifrah, Dov Shmotkin
The aim of the current study was to examine whether offspring of Holocaust survivors (OHS) gay men report higher interpersonal vulnerability in comparison to non-OHS gay men, and to further assess whether that vulnerability mediates the association between having a Holocaust background and mental health outcomes (depressive symptoms and life satisfaction). For this purpose, a community-dwelling sample of 79 middle-aged and older OHS and 129 non-OHS gay men completed measures of hostile-world scenario (HWS) in the interpersonal domain, satisfaction from current steady relationship, depressive symptoms and life satisfaction...
October 7, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29031785/prior-mental-disorders-and-subsequent-onset-of-chronic-back-or-neck-pain-findings-from-19-countries
#12
Maria Carmen Viana, Carmen C W Lim, Flavia Garcia Pereira, Sergio Aguilar-Gaxiola, Jordi Alonso, Ronny Bruffaerts, Peter de Jonge, Jose Miguel Caldas-de-Almeida, Siobhan O'Neill, Dan J Stein, Ali Al-Hamzawi, Corina Benjet, Graça Cardoso, Silvia Florescu, Giovanni de Girolamo, Josep Maria Haro, Chiyi Hu, Viviane Kovess-Masfety, Daphna Levinson, Marina Piazza, José Posada-Villa, Daniel Rabczenko, Ronald C Kessler, Kate M Scott
Associations between depression/anxiety and pain are well established, but its directionality is not clear. We examined the associations between temporally prior mental disorders and subsequent self-reported chronic back/neck pain onset, and investigated the variation in the strength of associations by timing of events during the life course, and by gender. Data were from population-based household surveys conducted in 19 countries (n=52,095). Lifetime prevalence and age-of-onset of 16 DSM-IV mental disorders, and the occurrence and age-of-onset of back/neck pain were assessed using the Composite International Diagnostic Interview...
October 11, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29031548/green-tea-protects-against-memory-deficits-related-to-maternal-deprivation
#13
Jefferson Menezes, Ben-Hur Neves, Mauren Souza, Pâmela Billig Mello-Carpes
Maternal deprivation (MD) in early life affects the development of the brain, causing cognitive losses in adulthood. Oxidative imbalance may be one of the factors that trigger these deficits. Therapies with antioxidant components, like green tea from Camellia sinensis (GT) has been used to treat or prevent memory deficits in a variety of conditions related to oxidative stress. Here we demonstrate that memory deficits caused by MD can be prevented by GT antioxidant activity in hippocampus. Pregnant female rats were used...
October 12, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/29030867/do-host-associated-gut-microbiota-mediate-the-effect-of-an-herbicide-on-disease-risk-in-frogs
#14
Sarah A Knutie, Caitlin Gabor, Kevin D Kohl, Jason R Rohr
1.Environmental stressors, such as pollutants, can increase disease risk in wildlife. For example, the herbicide atrazine affects host defenses (e.g. resistance and tolerance) of the amphibian chytrid fungus Batrachochytrium dendrobatidis (Bd), but the mechanisms for these associations are not always clear. Given that pollutants can alter the gut microbiota of hosts, which in turn can affect their health and immune systems, one potential mechanism by which pollutants could increase infection risk is by influencing host-associated microbiota...
October 14, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/29030490/early-sex-dependent-differences-in-response-to-environmental-stress
#15
Serafin Pérez-Cerezales, Priscila Ramos-Ibeas, Dimitrios Rizos, Pat Lonergan, Pablo Bermejo-Alvarez, Alfonso Gutierrez-Adan
Developmental plasticity enables the appearance of long-term effects in offspring caused by exposure to environmental stressors during embryonic and foetal life. These long-term effects can be traced to pre- and post-implantation development, and in both cases the effects are usually sex-specific. During preimplantation development, male and female embryos exhibit an extensive transcriptional dimorphism mainly driven by incomplete X-chromosome inactivation. These early developmental stages are crucial for the establishment of epigenetic marks that will be conserved throughout development, making it a particularly susceptible period for the appearance of long-term epigenetic-based phenotypes...
October 13, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29028111/dna-methylation-of-methylation-complex-genes-in-relation-to-stress-and-genome-wide-methylation-in-mother-newborn-dyads
#16
Christopher J Clukay, David A Hughes, Nicole C Rodney, Darlene A Kertes, Connie J Mulligan
OBJECTIVES: Early life stress is known to have enduring biological effects, particularly with respect to health. Epigenetic modifications, such as DNA methylation, are a possible mechanism to mediate the biological effect of stress. We previously found correlations between maternal stress, newborn birthweight, and genome-wide measures of DNA methylation. Here we investigate ten genes related to the methylation/demethylation complex in order to better understand the impact of stress on health...
October 13, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/29026448/newborn-genome-wide-dna-methylation-in-association-with-pregnancy-anxiety-reveals-a-potential-role-for-gabbr1
#17
Elise Beau Vangeel, Ehsan Pishva, Titia Hompes, Daniel van den Hove, Diether Lambrechts, Karel Allegaert, Kathleen Freson, Benedetta Izzi, Stephan Claes
BACKGROUND: There is increasing evidence for the role of prenatal stress in shaping offspring DNA methylation and disease susceptibility. In the current study, we aimed to identify genes and pathways associated with pregnancy anxiety using a genome-wide DNA methylation approach. METHODS: We selected 22 versus 23 newborns from our Prenatal Early Life Stress (PELS) cohort, exposed to the lowest or highest degree of maternal pregnancy anxiety, respectively. Cord blood genome-wide DNA methylation was assayed using the HumanMethylation450 BeadChip (HM450, n = 45) and candidate gene methylation using EpiTYPER (n = 80)...
2017: Clinical Epigenetics
https://www.readbyqxmd.com/read/29024713/a-lack-of-glun2a-containing-nmda-receptors-confers-a-vulnerability-to-redox-dysregulation-consequences-on-parvalbumin-interneurons-and-their-perineuronal-nets
#18
Romain Cardis, Jan-Harry Cabungcal, Daniella Dwir, Kim Q Do, Pascal Steullet
The GluN2A subunit of NMDA receptors (NMDARs) plays a critical role during postnatal brain development as its expression increases while Glun2B expression decreases. Mutations and polymorphisms in GRIN2A gene, coding for GluN2A, are linked to developmental brain disorders such as mental retardation, epilepsy, schizophrenia. Published data suggest that GluN2A is involved in maturation and phenotypic maintenance of parvalbumin interneurons (PVIs), and these interneurons suffer from a deficient glutamatergic neurotransmission via GluN2A-containing NMDARs in schizophrenia...
October 10, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29024677/eating-behavior-traits-associated-with-demographic-variables-and-implications-for-obesity-outcomes-in-early-childhood
#19
Nikki Boswell, Rebecca Byrne, Peter S W Davies
Despite ongoing investigation of children's eating behaviors to better understand the etiology of childhood obesity, few studies have aimed to determine differences in eating behavior based on psycho-social variables reflective of 'stressful' life circumstance. Cross-sectional data collected from parents of 977 Australian children (2.0-5.0 years) in an online survey was used to determine associations between parent-reported Children's Eating Behavior Questionnaire [CEBQ] sub-scales, child BMI z-scores and psycho-social variables...
October 9, 2017: Appetite
https://www.readbyqxmd.com/read/29024113/stress-related-cortisol-responsivity-modulates-prospective-memory
#20
Katharina Glienke, Martina Piefke
It is known that there is interindividual variation in behavioral and physiological stress reactions to the same stressor. The present study aimed at examining the impact of cortisol responsivity on performance in a complex real life-like prospective memory (PM) paradigm by a reanalysis of data published previously with the focus on the taxonomy of cognitive dimensions of PM. 21 male subjects were stressed with the Socially Evaluated Cold Pressor Test (SECPT) before the planning of intentions. Another group of 20 males underwent a control procedure...
October 10, 2017: Journal of Neuroendocrinology
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