keyword
MENU ▼
Read by QxMD icon Read
search

Early Life Stress

keyword
https://www.readbyqxmd.com/read/28448818/pegylated-bilirubin-nanoparticle-as-an-anti-oxidative-and-anti-inflammatory-demulcent-in-pancreatic-islet-xenotransplantation
#1
Min Jun Kim, Yonghyun Lee, Sangyong Jon, Dong Yun Lee
Transplanted islets suffer hypoxic stress, which leads to nonspecific inflammation. This is the major cause of islet graft failure during the early stage of intrahepatic islet transplantation. Although bilirubin has shown potent anti-oxidative and anti-inflammatory functions, its clinical applications have been limited due to its insolubility and short half-life. To overcome this problem, novel amphiphilic bilirubin nanoparticles are designed. Hydrophilic poly(ethylene glycol) (PEG) is conjugated to the hydrophobic bilirubin molecule...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28446693/lipid-consumption-in-coral-larvae-differs-among-sites-a-consideration-of-environmental-history-in-a-global-ocean-change-scenario
#2
Emily B Rivest, Chii-Shiarng Chen, Tung-Yung Fan, Hsing-Hui Li, Gretchen E Hofmann
The success of early life-history stages is an environmentally sensitive bottleneck for many marine invertebrates. Responses of larvae to environmental stress may vary due to differences in maternal investment of energy stores and acclimatization/adaptation of a population to local environmental conditions. In this study, we compared two populations from sites with different environmental regimes (Moorea and Taiwan). We assessed the responses of Pocillopora damicornis larvae to two future co-occurring environmental stressors: elevated temperature and ocean acidification...
April 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28443017/premature-brain-aging-in-baboons-resulting-from-moderate-fetal-undernutrition
#3
Katja Franke, Geoffrey D Clarke, Robert Dahnke, Christian Gaser, Anderson H Kuo, Cun Li, Matthias Schwab, Peter W Nathanielsz
Contrary to the known benefits from a moderate dietary reduction during adulthood on life span and health, maternal nutrient reduction during pregnancy is supposed to affect the developing brain, probably resulting in impaired brain structure and function throughout life. Decreased fetal nutrition delivery is widespread in both developing and developed countries, caused by poverty and natural disasters, but also due to maternal dieting, teenage pregnancy, pregnancy in women over 35 years of age, placental insufficiency, or multiples...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28441915/early-life-adversity-induced-long-term-epigenetic-programming-associated-with-early-onset-of-chronic-physical-aggression-studies-in-humans-and-animals
#4
Dimitry A Chistiakov, Vladimir P Chekhonin
OBJECTIVES: To examine whether chronic physical aggression (CPA) in adulthood can be epigenetically programmed early in life due to exposure to early-life adversity. METHODS: Literature search of public databases such as PubMed/MEDLINE and Scopus. RESULTS: Children/adolescents susceptible for CPA and exposed to early-life abuse fail to efficiently cope with stress that in turn results in the development of CPA later in life. This phenomenon was observed in humans and animal models of aggression...
April 26, 2017: World Journal of Biological Psychiatry
https://www.readbyqxmd.com/read/28439925/work-related-psychosocial-stress-and-the-risk-of-type-2-diabetes-in-later-life
#5
K-Y Pan, W Xu, F Mangialasche, L Fratiglioni, H-X Wang
OBJECTIVES: Although work-related psychosocial stress and type 2 diabetes mellitus (T2DM) have been investigated, the association between lifelong work stress and T2DM in later life remains unclear. This study examined whether high work stress increased the risk of T2DM risk in later life, accounting also for other sources of stress outside work, such as burden from household chores. METHODS: From the population-based prospective study SNAC-K, 2719 diabetes-free participants aged ≥60 years were identified and followed up for 6 years...
April 24, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28439771/neurobiological-programming-of-early-life-stress-functional-development-of-amygdala-prefrontal-circuitry-and-vulnerability-for-stress-related-psychopathology
#6
Michelle R VanTieghem, Nim Tottenham
Early adverse experiences are associated with heighted vulnerability for stress-related psychopathology across the lifespan. While extensive work has investigated the effects of early adversity on neurobiology in adulthood, developmental approaches can provide further insight on the neurobiological mechanisms that link early experiences and long-term mental health outcomes. In the current review, we discuss the role of emotion regulation circuitry implicated in stress-related psychopathology from a developmental and transdiagnostic perspective...
April 25, 2017: Current Topics in Behavioral Neurosciences
https://www.readbyqxmd.com/read/28439741/effect-of-victimization-on-impulse-control-and-binge-drinking-among-serious-juvenile-offenders-from-adolescence-to-young-adulthood
#7
Jordan P Davis, Tara M Dumas, Benjamin L Berey, Gabriel J Merrin, Joseph R Cimpian, Brent W Roberts
A vast literature has found longitudinal effects of early life stress on substance use and self-regulatory processes. These associations may vary by period-specific development among youth involved in the juvenile justice system. The current study used an accelerated longitudinal design and auto-regressive latent trajectory with structure residuals (ALT-SR) model to examine the within-person cross-lagged associations between binge drinking, impulse control, and victimization from 15 to 25 years of age. A large sample (N = 1100) of justice-involved youth were followed longitudinally for 7 years (M age baseline  = 15...
April 24, 2017: Journal of Youth and Adolescence
https://www.readbyqxmd.com/read/28439397/transcriptomic-analysis-of-maternally-provisioned-cues-for-phenotypic-plasticity-in-the-annual-killifish-austrofundulus-limnaeus
#8
Amie L Romney, Jason E Podrabsky
BACKGROUND: Genotype and environment can interact during development to produce novel adaptive traits that support life in extreme conditions. The development of the annual killifish Austrofundulus limnaeus is unique among vertebrates because the embryos have distinct cell movements that separate epiboly from axis formation during early development, can enter into a state of metabolic dormancy known as diapause and can survive extreme environmental conditions. The ability to enter into diapause can be maternally programmed, with young females producing embryos that do not enter into diapause...
2017: EvoDevo
https://www.readbyqxmd.com/read/28438343/developmental-and-transmittable-origins-of-obesity-associated-health-disorders
#9
REVIEW
Arin K Oestreich, Kelle H Moley
The current global obesity pandemic is clearly linked to both the increasing prevalence of, and preference for, foods high in calories, specifically fat and sucrose, and declining levels of daily physical activity. A less commonly discussed possible explanation is that risk of obesity begins in utero as a result of developmental plasticity during early life. This idea fits into the broader Developmental Origins of Health and Diseases (DOHAD) hypothesis, which holds that stressful in utero exposure manifests as disease in adulthood...
April 21, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28433802/role-of-environmental-stressors-in-determining-the-developmental-outcome-of-neonatal-anesthesia
#10
Ling-Sha Ju, Jiao-Jiao Yang, Nikolaus Gravenstein, Christoph N Seubert, Timothy E Morey, Colin Sumners, Terrie Vasilopoulos, Jian-Jun Yang, Anatoly E Martynyuk
BACKGROUND: The majority of studies evaluating neurocognition in humans who had procedures under anesthesia early in life found long-term deficits even though the typical anesthesia duration normalized to the human life span is much shorter than that shown to induce developmental abnormalities in rodents. Therefore, we studied whether subsequent environmental stressors contribute to deficiencies programmed by a brief neonatal etomidate exposure. METHODS: Postnatal days (P) 4, 5, or 6, Sprague-Dawley rats, pretreated with vehicle or the Na(+)-K(+)-2Cl(-) (NKCC1) inhibitor, bumetanide, received two injections of etomidate resulting in anesthesia for 2h...
April 7, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28433652/ketamine-potentiates-oxidative-stress-and-influences-behaviour-and-inflammation-in-response-to-lipolysaccharide-lps-exposure-in-early-life
#11
Gislaine Z Réus, Lutiana R Simões, Gabriela D Colpo, Giselli Scaini, Jean P Oses, Jaqueline S Generoso, Alan R Prossin, Rima Kaddurah-Daouk, João Quevedo, Tatiana Barichello
Immune activation (IA) during the early neonatal period is a risk factor for the development of schizophrenia. Lipopolysaccharide (LPS) injected in neonates lead to behavioral and brain changes that persist to adult life. We investigated oxidative stress, levels of cytokines, and the locomotor activity of IA in a schizophrenia animal model in which neonatal male Wistar rats were administered with an injection of LPS (50 μg/kg) on postnatal day 3 and different doses of ketamine (5, 15 and 25 mg/kg) for 7 days during adulthood...
April 19, 2017: Neuroscience
https://www.readbyqxmd.com/read/28433469/delayed-effect-of-early-life-corticosterone-treatment-on-adult-anti-predator-behavior-in-a-common-passerine
#12
Jacquelyn K Grace, Laure Martin-Gousset, Frédéric Angelier
Acute, short-term effects of early-life stress and associated glucocorticoid upregulation on behavior are widely documented across vertebrates. However, the persistence and severity of these effects are largely unknown, especially through the adult stage and in wild species. Here, we investigate long-term effects of experimental post-natal increases in a circulating glucocorticoid on antipredator behavior in wild house sparrows (Passer domesticus) tested in captivity. We manipulate circulating corticosterone concentration in wild, free-living nestlings, transfer fledglings to captivity, and test juveniles and adults for two measures of antipredator behavior: evasiveness during a direct human encounter, and propensity to escape from a risky environment...
April 19, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28433090/neural-biomarker-and-early-temperament-predict-increased-internalizing-symptoms-after-a%C3%A2-natural-disaster
#13
Alexandria Meyer, Carla Kmett Danielson, Allison P Danzig, Vickie Bhatia, Sarah R Black, Evelyn Bromet, Gabrielle Carlson, Greg Hajcak, Roman Kotov, Daniel N Klein
OBJECTIVE: Although most people will experience a traumatic event at some point in their life, only some will develop significant psychological symptoms in the aftermath. In the current study, we use a preexisting longitudinal study located in Long Island to examine the impact of Hurricane Sandy on internalizing symptoms in a large sample of children. We focused on temperamental fear and a biomarker of risk for anxiety, the error-related negativity (ERN). The ERN is a negative deflection in the event-related potential (ERP) occurring when individuals make mistakes and is increased in anxious individuals...
May 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28433086/intergenerational-transmission-of-maternal-childhood-maltreatment-exposure-implications-for-fetal-brain-development
#14
REVIEW
Claudia Buss, Sonja Entringer, Nora K Moog, Philipp Toepfer, Damien A Fair, Hyagriv N Simhan, Christine M Heim, Pathik D Wadhwa
OBJECTIVE: Growing evidence suggests the deleterious consequences of exposure to childhood maltreatment (CM) not only might endure over the exposed individual's lifespan but also might be transmitted across generations. The time windows, mechanisms, and targets of such intergenerational transmission are poorly understood. The prevailing paradigm posits that mother-to-child transmission of the effects of maternal CM likely occurs after her child's birth. The authors seek to extend this paradigm and advance a transdisciplinary framework that integrates the concepts of biological embedding of life experiences and fetal origins of health and disease risk...
May 2017: Journal of the American Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28421528/postnatal-lps-challenge-impacts-escape-learning-and-expression-of-plasticity-factors-mmp9-and-timp1-in-rats-effects-of-repeated-training
#15
Alexander Trofimov, Tatyana Strekalova, Niall Mortimer, Olga Zubareva, Alexander Schwarz, Evgeniy Svirin, Aleksei Umriukhin, Andrei Svistunov, Klaus-Peter Lesch, Victor Klimenko
Bacterial intoxication associated with inflammatory conditions during development can impair brain functions, in particular evolutionarily novel forms of memory, such as explicit learning. Little is known about the dangers of early-life inflammation on more basic forms of learning, for example, the acquisition of motor escape abilities, which are generally better preserved under pathological conditions. To address this limitation in knowledge, an inflammatory response was elicited in Wistar pups by lipopolysaccharide (LPS) injections (25 μg/kg) on postnatal days P15, P18 and P21...
April 18, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28420139/interplay-between-oxidative-stress-and-nutrient-sensing-signaling-in-the-developmental-origins-of-cardiovascular-disease
#16
REVIEW
You-Lin Tain, Chien-Ning Hsu
Cardiovascular disease (CVD) presents a global health burden, despite recent advances in management. CVD can originate from early life by so-called "developmental origins of health and disease" (DOHaD). Epidemiological and experimental evidence supports that early-life insults can induce programming of later CVD. Underlying the DOHaD concept, early intervention may offset programming process to prevent the development of CVD, namely reprogramming. Oxidative stress and nutrient sensing signals have been considered to be major mechanisms of cardiovascular programming, while the interplay between these two mechanisms have not been examined in detail...
April 15, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28419968/current-insights-into-pathogenesis-of-parkinson-s-disease-approach-to-mevalonate-pathway-and-protective-role-of-statins
#17
REVIEW
Seyed Soheil Saeedi Saravi, Seyed Sobhan Saeedi Saravi, Katayoun Khoshbin, Ahmad Reza Dehpour
Although Parkinson's disease (PD) is considered as the second most common life threatening age-related neurodegenerative disorder, but the underlying mechanisms for pathogenesis of PD are remained to be fully found. However, a complex relationship between genetic and environmental predisposing factors are involved in progression of PD. Dopaminergic neuronal cell death caused by mutations and accumulation of α-synuclein in Lewy bodies and neurites was suggested as the main strategy for PD, but current studies have paid attention to the role of mevalonate pathway in incidence of neurodegenerative diseases including PD...
April 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28419390/adolescent-stress-as-a-driving-factor-for-schizophrenia-development-a-basic-science-perspective
#18
Felipe V Gomes, Anthony A Grace
Schizophrenia has been associated with heightened stress responsivity in adolescence that precedes onset of psychosis. We now report that multiple stressors during adolescence in normal rats leads to deficits in adults analogous to that seen in schizophrenia patients. Moreover, impairment of stress control by lesion of the prelimbic prefontal cortex in adolescence caused previously subthreshold levels of stress to induce these deficit states when tested as adults. Thus, predisposition to stress hyper-responsivity, or exposure to substantial stressors, during adolescence can trigger a cascade of events that result in a schizophrenia-like profile in adults...
May 1, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28418704/false-negatives-for-remote-life-detection-on-ocean-bearing-planets-lessons-from-the-early-earth
#19
Christopher T Reinhard, Stephanie L Olson, Edward W Schwieterman, Timothy W Lyons
Ocean-atmosphere chemistry on Earth has undergone dramatic evolutionary changes throughout its long history, with potentially significant ramifications for the emergence and long-term stability of atmospheric biosignatures. Though a great deal of work has centered on refining our understanding of false positives for remote life detection, much less attention has been paid to the possibility of false negatives, that is, cryptic biospheres that are widespread and active on a planet's surface but are ultimately undetectable or difficult to detect in the composition of a planet's atmosphere...
April 2017: Astrobiology
https://www.readbyqxmd.com/read/28416629/individual-differences-in-fear-extinction-and-anxiety-like-behavior
#20
Gabrielle King, Elliot Scott, Bronwyn M Graham, Rick Richardson
There is growing appreciation for the substantial individual differences in the acquisition and inhibition of aversive associations, and the insights this might give into identifying individuals particularly vulnerable to stress and psychopathology. We examined whether animals that differed in rate of extinction (i.e., Fast versus Slow) were different in their response to an acute stress in adulthood or following a chronic stress that occurred either early or later in life. We found that Slow Extinguishers had significantly poorer extinction retention than Fast Extinguishers, but an acute stressor did not differentially affect anxiety-like behavior in the two groups...
May 2017: Learning & Memory
keyword
keyword
84052
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"