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https://www.readbyqxmd.com/read/29665420/distortion-matched-t-1-maps-and-unbiased-t-1-weighted-images-as-anatomical-reference-for-high-resolution-fmri
#1
Wietske van der Zwaag, Pieter F Buur, Alessio Fracasso, Tessa van Doesum, Kamil Uludag, Maarten Versluis, José P Marques
The increasing availability of ultra-high field scanners has led to a growing number of submillimetre fMRI studies in humans, typically targeting the gray matter at different cortical depths. In most analyses, the definition of surfaces at different cortical depths is based on an anatomical image with different contrast and distortions than the functional images. Here, we introduce a novel sequence providing bias-field corrected T1 -weighted images and T1 -maps with distortions that match those of the fMRI data, with an image acquisition time significantly shorter than standard T1 -weighted anatomical imaging...
April 14, 2018: NeuroImage
https://www.readbyqxmd.com/read/29664815/long-term-posttraumatic-survival-of-spinal-fracture-patients-in-northern-finland
#2
Ville Niemi-Nikkola, Nelli Saijets, Henrikka Ylipoussu, Pietari Kinnunen, Juha Pesälä, Pirkka Mäkelä, Markku Alen, Mauri Kallinen, Aki Vainionpää
STUDY DESIGN: A retrospective epidemiological study. OBJECTIVE: To reveal the long-term survival and causes of death after traumatic spinal fracture (TSF) and to determine the possible factors predicting death. SUMMARY OF BACKGROUND DATA: Increased mortality following osteoporotic spinal fracture has been represented in several studies. Earlier studies concerning mortality after TSF have focused on specific types of fractures, or else only the mortality of the acute phases has been documented...
April 16, 2018: Spine
https://www.readbyqxmd.com/read/29663932/studies-on-the-antibacterial-activity-and-mechanism-of-antimicrobial-peptides-against-drug-resistant-bacteria
#3
Xiaofang Luo, Yanjun Liu, Zuodong Qin, Zhiyuan Jin, Liting Xu, Yang Liu, Linyan Cao, Fulin He, Xiaohong Gu, Xiaoping Ouyang
Antibiotic resistance is a growing threat to human health. More than anything else, multidrug-resistant gram-negative bacteria pose the biggest challenge to healthcare, which is predominantly due to the lack of effective therapeutic options. In the present study, we investigated the activities of peptides HX-12A, HX-12B and HX-12C against MDRAB and MDRKP isolates in vitro. Those three peptides displayed high antibacterial activities and rapid bactericidal effects against MDRAB and MDRKP isolates. Additionally, the peptides retained their activity even being present in pH 6...
March 1, 2018: Journal of Biomedical Nanotechnology
https://www.readbyqxmd.com/read/29661713/review-with-novel-markers-facilitates-precise-categorization-of-41-cases-of-diagnostically-challenging-undifferentiated-small-round-cell-tumors-a-clinicopathologic-immunophenotypic-and-molecular-analysis
#4
Isidro Machado, Akihiko Yoshida, María Gema Nieto Morales, Lucas Faria Abrahão-Machado, Samuel Navarro, Julia Cruz, Javier Lavernia, Antonina Parafioriti, Piero Picci, Antonio Llombart-Bosch
BACKGROUND: Despite extensive immunohistochemical (IHC) and molecular studies combined with morphologic findings, a group of round/ovoid cell tumors histologically similar to Ewing sarcomas (ES) but lacking EWSR1-rearrangements may remain unclassifiable. DESIGN: We retrospectively analyzed 41 Ewing-like tumors (formalin-fixed, paraffin-embedded) previously determined as negative or non-informative for EWSR1-rearrangements by FISH and/or RT-PCR. A new histopathology revision and additional IHC and molecular analyses were carried out in order to investigate whether additional IHC and/or molecular testing in combination with the morphological findings may help in reaching a definitive diagnosis...
November 29, 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29660288/atomic-orbital-implementation-of-extended-symmetry-adapted-perturbation-theory-xsapt-and-benchmark-calculations-for-large-supramolecular-complexes
#5
Ka Un Lao, John M Herbert
We report an implementation of extended symmetry-adapted perturbation theory (XSAPT) in the atomic orbital basis, extending this method to systems where the monomers are large. In our "XSAPT(KS)" approach, monomers are described using range-separated Kohn-Sham (KS) density functionals whose asymptotic behavior is set by tuning the range-separation parameter, ω, in a monomer-specific way. This is accomplished either by conventional ionization potential (IP)-based tuning, in which ω is adjusted to satisfy the condition εHOMO (ω) = -IP(ω), or else using a so-called "global density-dependent" (GDD) condition, in which ω is fixed based on the size of the exchange hole...
April 16, 2018: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/29659085/gastrointestinal-recurrent-acute-pancreatitis-with-a-large-fluid-collection-pseudocyst-or-else
#6
Z Nabi, J R Singh, D Nageshwar Reddy
No abstract text is available yet for this article.
May 2018: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29658872/reoperative-cardiac-surgery-part-ii
#7
Curtis G Tribble
The preparation for a reoperative cardiac surgical case was covered in Part I of this two part review [Tribble 2018]. Part II will cover primarily intraoperative strategies and techniques.  As noted in Part I, there has been surprisingly little written about the strategies and techniques of reoperative cardiac surgery. Thus, the goal of this two-part review is to collect and collate some of the lessons, abjurations, and tenets related to reoperative cardiac surgery that may be valuable to cardiac surgeons, especially those in training or early in their careers...
April 10, 2018: Heart Surgery Forum
https://www.readbyqxmd.com/read/29656532/of-lamp-posts-keys-and-fabled-drunkards-a-perspectival-tale-of-4-guidelines
#8
Trisha Greenhalgh
BACKGROUND: Evidence-based medicine is the application of research findings to inform individual clinical decisions. There is a tension-both philosophical and practical-between the average result from a population study and the circumstances and needs of an individual patient. This personal account of "evidence-based" trauma care illustrates and explores this tension. THE CASE: The author, a keen athlete, describes her experience of a high-impact cycle accident that led to limb fractures (which were diagnosed and treated according to evidence-based guidelines) and also an occult injury to the cervical spine (which was not diagnosed at the time)...
April 15, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29655474/prudent-use-of-antimicrobials-in-exotic-animal-medicine
#9
REVIEW
Els M Broens, Ingeborg M van Geijlswijk
Reduction of antimicrobial use can result in reduction of resistance in commensal bacteria. In exotic animals, information on use of antimicrobials and resistance in commensals and pathogens is scarce. However, use of antimicrobials listed as critically important antimicrobials for human medicine seems high in exotic animals. Ideally, the selection of a therapy should be based on an accurate diagnosis and antimicrobial susceptibility testing. When prescribing antimicrobials based on empiricism, knowledge of the most common pathogens causing specific infections and the antimicrobial spectrum of antimicrobial agents is indispensable...
May 2018: Veterinary Clinics of North America. Exotic Animal Practice
https://www.readbyqxmd.com/read/29649132/effect-of-climate-and-land-use-on-the-spatio-temporal-variability-of-tick-borne-bacteria-in-europe
#10
Roberto Rosà, Veronica Andreo, Valentina Tagliapietra, Ivana Baráková, Daniele Arnoldi, Heidi Christine Hauffe, Mattia Manica, Fausta Rosso, Lucia Blaňarová, Martin Bona, Marketa Derdáková, Zuzana Hamšíková, Maria Kazimírová, Jasna Kraljik, Elena Kocianová, Lenka Mahríková, Lenka Minichová, Ladislav Mošanský, Mirko Slovák, Michal Stanko, Eva Špitalská, Els Ducheyne, Markus Neteler, Zdenek Hubálek, Ivo Rudolf, Kristyna Venclikova, Cornelia Silaghi, Evelyn Overzier, Robert Farkas, Gábor Földvári, Sándor Hornok, Nóra Takács, Annapaola Rizzoli
The incidence of tick-borne diseases caused by Borrelia burgdorferi sensu lato, Anaplasma phagocytophilum and Rickettsia spp. has been rising in Europe in recent decades. Early pre-assessment of acarological hazard still represents a complex challenge. The aim of this study was to model Ixodes ricinus questing nymph density and its infection rate with B. burgdorferi s.l., A. phagocytophilum and Rickettsia spp. in five European countries (Italy, Germany, Czech Republic, Slovakia, Hungary) in various land cover types differing in use and anthropisation (agricultural, urban and natural) with climatic and environmental factors (Normalized Difference Vegetation Index (NDVI), Normalized Difference Water Index (NDWI), Land Surface Temperature (LST) and precipitation)...
April 12, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29648953/field-sanitation-in-u-s-agriculture-evidence-from-naws-and-future-data-needs
#11
Anita Alves Pena, Edward R Teather-Posadas
OBJECTIVES: We studied relationships between demographic and work-related characteristics and exposure to health-related risk associated with field sanitation within the population of U.S. farmworkers while critically examining adequacy of existing data toward understanding patterns. METHODS: We used statistical and econometric large-sample data methods to analyze correlations between observable variables and access to field sanitation as measured by responses to the nationally and regionally representative National Agricultural Workers Survey (NAWS)...
2018: Journal of Agromedicine
https://www.readbyqxmd.com/read/29643919/an-update-on-molecular-cat-allergens-fel-d-1-and-what-else-chapter-1-fel-d-1-the-major-cat-allergen
#12
REVIEW
B Bonnet, K Messaoudi, F Jacomet, E Michaud, J L Fauquert, D Caillaud, B Evrard
Background: Cats are the major source of indoor inhalant allergens after house dust mites. The global incidence of cat allergies is rising sharply, posing a major public health problem. Ten cat allergens have been identified. The major allergen responsible for symptoms is Fel d 1, a secretoglobin and not a lipocalin, making the cat a special case among mammals. Main body: Given its clinical predominance, it is essential to have a good knowledge of this allergenic fraction, including its basic structure, to understand the new exciting diagnostic and therapeutic applications currently in development...
2018: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/29642875/comparing-the-performance-of-circulating-cathodic-antigen-and-kato-katz-techniques-in-evaluating-schistosoma-mansoni-infection-in-areas-with-low-prevalence-in-selected-counties-of-kenya-a-cross-sectional-study
#13
Collins Okoyo, Elses Simiyu, Sammy M Njenga, Charles Mwandawiro
BACKGROUND: Kato-Katz technique has been the mainstay test in Schistosoma mansoni diagnosis in endemic areas. However, recent studies have documented its poor sensitivity in evaluating Schistosoma mansoni infection especially in areas with lower rates of transmission. It's the primary diagnostic tool in monitoring impact of the Kenya national school based deworming program on infection transmission, but there is need to consider a more sensitive technique as the prevalence reduces. Therefore, this study explored the relationship between results of the stool-based Kato-Katz technique with urine-based point-of-care circulating cathodic antigen (POC-CCA) test in view to inform decision-making by the program in changing from Kato-Katz to POC-CCA test...
April 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29621859/infants-of-emotionally-dysregulated-or-borderline-personality-disordered-mothers-issues-and-management-in-primary-care
#14
Gisèle Apter, Anne E Sved Williams
BACKGROUND: Knowledge has increased regarding the developmental needs and capabilities of infants, and parental behaviours that support optimum infant development. Despite a better understanding of the emotional dysregulation in borderline personality disorder (BPD) and its effects on infants, general practitioners have had few guidelines for how to recognise and help emotionally dysregulated mother-infant dyads. OBJECTIVE: This article focuses on the behaviours and needs of infants whose mothers have BPD, including knowledge and skills for primary care practitioners to help these troubled families...
April 2018: Australian journal of general practice
https://www.readbyqxmd.com/read/29621741/harm-from-others-drinking-related-aggression-violence-and-misconduct-in-five-asian-countries-and-the-implications
#15
Orratai Waleewong, Anne-Marie Laslett, Richard Chenhall, Robin Room
BACKGROUND: Harm from alcohol-attributable aggression and violence is linked to diminished personal safety and reduced physical and mental health and wellbeing in many countries. But there has been limited evidence on these harms in low- and middle-income countries (LMICs). This study measured harm from others' drinking-related aggression, violence and misconduct in five Asian LMICs (Thailand, Sri Lanka, India, Vietnam, and Lao PDR), aiming to compare the magnitude and pattern of harm across countries by gender, age group, educational level, rurality, and country-level indicators...
April 2, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29618742/early-life-stress-induces-long-term-changes-in-limbic-areas-of-a-teleost-fish-the-role-of-catecholamine-systems-in-stress-coping
#16
Marco A Vindas, Stefanos Fokos, Michail Pavlidis, Erik Höglund, Sylvia Dionysopoulou, Lars O E Ebbesson, Nikolaos Papandroulakis, Catherine R Dermon
Early life stress (ELS) shapes the way individuals cope with future situations. Animals use cognitive flexibility to cope with their ever-changing environment and this is mainly processed in forebrain areas. We investigated the performance of juvenile gilthead seabream, previously subjected to an ELS regime. ELS fish showed overall higher brain catecholaminergic (CA) signalling and lower brain derived neurotrophic factor (bdnf) and higher cfos expression in region-specific areas. All fish showed a normal cortisol and serotonergic response to acute stress...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29616744/craniofacial-development-discoveries-made-in-the-chicken-embryo
#17
John Abramyan, Joy M Richman
The aim of this review is to highlight some of the key contributions to our understanding of craniofacial research from work carried out with the chicken and other avian embryos. From the very first observations of neural crest cell migration to the fusion of the primary palate, the chicken has proven indispensable in facilitating craniofacial research. In this review we will look back to the premolecular studies where "cut and paste" grafting experiments mapped the fate of cranial neural crest cells, the role of different tissue layers in patterning the face, and more recently the contribution of neural crest cells to jaw size and identity...
2018: International Journal of Developmental Biology
https://www.readbyqxmd.com/read/29616445/voluntary-exercise-during-adolescence-mitigated-negative-the-effects-of-maternal-separation-stress-on-the-depressive-like-behaviors-of-adult-male-rats-role-of-nmda-receptors
#18
Forouzan Fattahi Masrour, Maghsoud Peeri, Mohammad Ali Azarbayjani, Mir-Jamal Hosseini
Evidence indicates that experiencing early-life stress (ELS) is a risk factor for the development of mental disorders such as depression. Maternal separation stress (MS) is a valid animal model of ELS that caused to induce long-lasting effects on the brain and behaviors of animals. It hypothesized that adolescence is a critical stage in which the brain is still developing, and applying (non)pharmacological therapies in this period may attenuate the effects of ELS on the brain and behavior. Male rats were subjected to MS from postnatal day (PND) 2-14, and the stressed animals were then treated with (1) chronic fluoxetine (FLX) (5 mg/kg) and (2) voluntary running wheel exercise (RW) from PND 30, for 30 days...
April 3, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29615033/health-sector-involvement-in-the-management-of-female-genital-mutilation-cutting-in-30-countries
#19
R Elise B Johansen, Mai Mahgoub Ziyada, Bettina Shell-Duncan, Adriana Marcusàn Kaplan, Els Leye
BACKGROUND: For the last decades, the international community has emphasised the importance of a multisectoral approach to tackle female genital mutilation (FGM/C). While considerable improvement concerning legislations and community involvement is reported, little is known about the involvement of the health sector. METHOD: A mixed methods approach was employed to map the involvement of the health sector in the management of FGM/C both in countries where FGM/C is a traditional practice (countries of origin), and countries where FGM/C is practiced mainly by migrant populations (countries of migration)...
April 4, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29614108/for-better-or-worse-factors-predicting-outcomes-of-family-care-of-older-people-over-a-one-year-period-a-six-country-european-study
#20
Daniel Lüdecke, Barbara Bien, Kevin McKee, Barbro Krevers, Elizabeth Mestheneos, Mirko Di Rosa, Olaf von dem Knesebeck, Christopher Kofahl
OBJECTIVES: Demographic change has led to an increase of older people in need of long-term care in nearly all European countries. Informal carers primarily provide the care and support needed by dependent people. The supply and willingness of individuals to act as carers are critical to sustain informal care resources as part of the home health care provision. This paper describes a longitudinal study of informal care in six European countries and reports analyses that determine those factors predicting the outcomes of family care over a one-year period...
2018: PloS One
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