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Els Evenboer, Anne-Marie Huyghen, Jolanda Tuinstra, Erik Knorth, Sijmen A Reijneveld
Behavioral and emotional problems can lead to severe restrictions in the functioning of children and to an impaired development. The types of support for children vary greatly between care providers. The aim of this study is to apply the Taxonomy of Care for Youth (TOCFY) and to make an inventory of the core elements and program elements of the various types of support for children with behavioral and emotional problems that were offered overall and per main types of providers in a delineated region. We assessed the types of support to children (N = 621) by applying TOCFY...
June 18, 2018: Social Work in Health Care
Lisa Holmlund, Claes Hultling, Eric Asaba
Involving persons with spinal cord injury (SCI) as experts in their lives is important for research to design relevant health care interventions. The purpose of this study was to use photovoice methods to explore experiences of barriers and possibilities in return to work among working adults with SCI. The photovoice group consisted of six persons living with SCI that met weekly over 2 months to share and discuss photos related to return to work. Five themes were identified: (a) there is only one way, (b) welcome back-or not, (c) to be like anyone else-or to be perceived as someone else, (d) friction in the absence of clarity, and (e) finding integrated strategies for everyday life with work...
June 1, 2018: Qualitative Health Research
Annelie Gutsch, Els Keunen, Gea Guerriero, Jenny Renaut, Ann Cuypers, Jean-François Hausman, Kjell Sergeant
Cadmium (Cd) is a non-essential, toxic heavy metal that poses serious threats to both the ecosystem and the health of humans. Plants employ various cellular and molecular mechanisms to minimize the impact of Cd toxicity and the cell walls function as defensive barrier during Cd exposure. In this study, we adopted a quantitative gel-based proteomic approach (two-dimensional difference gel electrophoresis) to investigate changes in the abundance of cell wall- and soluble proteins in stems of Medicago sativa L...
June 15, 2018: Plant Biology
Eline Overwater, Luisa Marsili, Marieke J H Baars, Annette F Baas, Irma van de Beek, Eelco Dulfer, Johanna M van Hagen, Yvonne Hilhorst-Hofstee, Marlies Kempers, Ingrid P Krapels, Leonie A Menke, Judith M A Verhagen, Kak K Yeung, Petra J G Zwijnenburg, Maarten Groenink, Peter van Rijn, Marjan M Weiss, Els Voorhoeve, J Peter van Tintelen, Arjan C Houweling, Alessandra Maugeri
Simultaneous analysis of multiple genes using next generation sequencing (NGS) technology has become widely available. Copy number variations (CNVs) in disease-associated genes have emerged as a cause for several hereditary disorders. CNVs are, however, not routinely detected using NGS analysis. The aim of this study was to assess the diagnostic yield and the prevalence of CNVs using our panel of Hereditary Thoracic Aortic Disease (H-TAD) associated genes. 810 patients suspected of H-TAD were analysed by targeted NGS analysis of 21 H-TAD associated genes...
June 16, 2018: Human Mutation
Freja Scheys, Els Jm Van Damme, Kristof De Schutter, An Staes, Kris Gevaert, Guy Smagghe
N-glycosylation is one of the most abundant and conserved protein modifications in eukaryotes. The attachment of N-glycans to proteins can modulate their properties and influences numerous important biological processes, such as protein folding and cellular attachment. Recently, it has been shown that protein N-glycosylation plays a vital role in insect development and survival, which makes the glycans an interesting target for pest control. Despite the importance of protein N-glycosylation in insects, knowledge about insect N-glycoproteomes is scarce...
June 12, 2018: Insect Biochemistry and Molecular Biology
Frédéric Basso, Olivia Petit, Sophie Le Bellu, Saadi Lahlou, Aïda Cancel, Jean-Luc Anton
Every day, people are exposed to images of appetizing foods that can lead to high-calorie intake and contribute to overweight and obesity. Research has documented that manipulating the visual perspective from which eating is viewed helps resist temptation by altering the appraisal of unhealthy foods. However, the neural basis of this effect has not yet been examined using neuroimaging methods. Moreover, it is not known whether the benefits of this strategy can be observed when people, especially overweight, are not explicitly asked to imagine themselves eating...
June 12, 2018: Appetite
Christian de Pee
The Song Empire (960-1279 CE) had a larger population, a higher agricultural output, a more efficient infrastructure, and a more extensive monetary system than any previous empire in Chinese history. As local jurisdictions during the eleventh century became entangled in empire-wide economic relations and trans-regional commercial litigation, imperial officials sought to reduce the bewildering movement of people, goods, and money to an immanent cosmic pattern. They reasoned that because money and commerce brought to imperial subjects the goods they required to survive, money and commerce must be beneficent, and because they were beneficent, they must conform to the immanent pattern of the moral cosmos, as did everything else that was enduringly sustaining of life and wellbeing...
June 2018: History of Science; An Annual Review of Literature, Research and Teaching
Karin Huijsdens-van Amsterdam, Lieve Page-Christiaens, Nicola Flowers, Michael D Bonifacio, Katie M Battese Ellis, Ida Vogel, Else Marie Vestergaard, Javier Miguelez, Mario Henrique Burlacchini de Carvalho, Erik A Sistermans, Mark D Pertile
False-negative cell-free DNA (cfDNA) screening results involving Down syndrome are rare, but have high clinical impact on patients and their healthcare providers. Understanding the biology behind these results may allow for improved diagnostic follow-up and counseling. In 5 different centers offering cfDNA prenatal screening, 9 false-negative results were documented in 646 confirmed cases of trisomy 21; a false-negative rate of 1.4% (95% CI, 0.7-2.6). False-negative results included 4 cases of classical trisomy 21 and 5 cases with a de novo 21q;21q rearrangement...
June 13, 2018: European Journal of Human Genetics: EJHG
Els Leye, Emilomo Ogbe, Maaike Heyerick
BACKGROUND: Hymen reconstruction (HR) involves the restoration of the hymeneal membrane's gross anatomical integrity. Among the medical profession, hymen reconstruction receives particular attention and its necessity is debated because the surgery is not medically indicated, and often reveals conflicting social norms on virginity and marriageability between health professionals and their patients. The focus of this paper is not to address the many open questions that the ethics and politics around HR reveal, but rather aims at contributing to the much-needed empirical evidence...
June 13, 2018: BMC Women's Health
Els van Wijngaarden, Hugo van der Wedden, Zerline Henning, Rikke Komen, Anne-Mei The
INTRODUCTION: Too often dementia care is still fragmented and unresponsive to the needs of people living with dementia and their family caregivers. To develop effective health care services, in-depth insight into the experiences of family caregivers is a prerequisite. METHODS: This Dutch study is a qualitative interview study. The aim was twofold: 1) to develop an in-depth understanding of what it means to live with dementia and 2) to gain insight into what constitutes the art of living with dementia, both from the perspective of family caregivers...
2018: PloS One
Yang Hu, Lisheng He, Lei Zhang, Thorben Wölk, Jean-Claude Dreher, Bernd Weber
People tend to pay the generosity they receive from a person forward to someone else even if they have no chance to reciprocate directly. This phenomenon, known as paying-it-forward (PIF) reciprocity, crucially contributes to the maintenance of a cooperative human society by passing kindness among strangers and has been widely studied in evolutionary biology. To further examine its neural implementation and underlying computations, we used functional magnetic resonance imaging (fMRI) together with computational modeling...
June 7, 2018: Social Cognitive and Affective Neuroscience
Laurens J De Sadeleer, Stijn E Verleden, Els De Dycker, Jonas Yserbyt, Johny A Verschakelen, Eric K Verbeken, Benoit Nemery, Geert M Verleden, Frederik Hermans, Bart M Vanaudenaerde, Wim A Wuyts
BACKGROUND AND OBJECTIVE: Although idiopathic pulmonary fibrosis (IPF) patients experience a worse survival compared with chronic hypersensitivity pneumonitis (CHP), organic dust exposure is a known risk factor for both IPF and CHP. METHODS: We divided patients diagnosed with IPF, based on their exposure to moulds/birds (absent: group A; present: group B). We retrospectively compared pulmonary function and survival between groups A and B, and a separate CHP cohort (group C)...
June 13, 2018: Respirology: Official Journal of the Asian Pacific Society of Respirology
Katherine J Karriker-Jaffe, Libo Li, Thomas K Greenfield
BACKGROUND & AIMS: Alcohol's harms to others (AHTO) may cause substantial distress, particularly when harms are perpetrated by close others. One challenge to identifying causal impacts is that people harmed by drinkers differ in many ways from those not so harmed, so our aim was to assess mental health in relation to two serious types of AHTO, financial harm and assault by someone who had been drinking, using propensity score (PS) weighting to adjust for potentially confounding differences...
June 12, 2018: Addiction
Anne Castles, Kathleen Rastle, Kate Nation
There is intense public interest in questions surrounding how children learn to read and how they can best be taught. Research in psychological science has provided answers to many of these questions but, somewhat surprisingly, this research has been slow to make inroads into educational policy and practice. Instead, the field has been plagued by decades of "reading wars." Even now, there remains a wide gap between the state of research knowledge about learning to read and the state of public understanding...
June 2018: Psychological Science in the Public Interest: a Journal of the American Psychological Society
Julie Abildgaard, Else Rubaek Danielsen, Emma Dorph, Carsten Thomsen, Anders Juul, Caroline Ewertsen, Bente Klarlund Pedersen, Anette Tønnes Pedersen, Thorkil Ploug, Birgitte Lindegaard
Context: Menopause is associated with an increased incidence of insulin resistance and diabetes. Objective: The aim of this study was to explore the lipid deposition in liver and skeletal muscle and investigate the association with insulin sensitivity in post- and premenopausal women. Design, setting, participants and measurements: Single-centre cross-sectional study of 55 healthy women between 45- and 60 years of age. We measured lipid deposition in the liver with MR spectroscopy, intramuscular- and intraabdominal lipid deposition with MRI, body composition with a DEXA-scan and insulin sensitivity with the composite Matsuda Index...
June 7, 2018: Journal of Clinical Endocrinology and Metabolism
Salcey G Amzand, Bert L Luteijn, Els van der Ven, Jan P Bogers, Jean-Paul Selten
OBJECTIVE: The aim of this study was to establish the specificity and sensitivity of a simplified screening test based on diastolic blood pressure and waist circumference for predicting metabolic syndrome. METHOD: Demographic, anthropometric (waist circumference and systolic and diastolic blood pressure) and laboratory (triglyceride, high-density lipoprotein and fasting glucose) data were collected from a large cohort of Dutch patients with a schizophrenia spectrum disorder in order to determine whether patients fulfilled the Western criteria of the International Diabetes Federation (IDF) for metabolic syndrome...
June 1, 2018: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Jeremy D Coplan, Anna V Rozenboym, Sasha L Fulton, Venkatesh Panthangi, Jean Tang, Lakshmi Thiramangalakdi, Tarique D Perera, Yang Liu, Haroon Kamran, Michael J Owens, Charles B Nemeroff, Leonard A Rosenblum, John G Kral, Louis Salciccioli, Jason Lazar
Background: Early life stress (ELS) in macaques in the form of insecure maternal attachment putatively induces epigenetic adaptations resulting in a "thrifty phenotype" throughout the life cycle. For instance, ELS induces persistent increases in insulin resistance, hippocampal and corpus callosum atrophy and reduced "behavioral plasticity", which, taken together, engenders an increased risk for mood and anxiety disorders in humans but also a putative sparing of calories...
February 2018: Neurobiology of Stress
Anne Sofie Gram, Martin Bæk Petersen, Jonas Salling Quist, Mads Rosenkilde, Bente Stallknecht, Else-Marie Bladbjerg
Obesity and exercise constitute important factors for cardiovascular disease risk, but the long-term effects of different exercise modalities on haemostatic biomarkers are not well elucidated. We investigated the effects of 6 months of active commuting or leisure-time exercise on measures of fibrin turnover in individuals who are overweight and obese. Ninety younger (20-40 years), sedentary, healthy women and men who are overweight and obese (BMI: 25-35 kg/m2 ) were randomised to 6 months of habitual lifestyle (CON, n =16), active commuting (BIKE, n =19), or leisure-time exercise of moderate (MOD, ∼50% VO2 peak reserve, n =31) or vigorous intensity (VIG, ∼70% VO2 peak reserve, n =24)...
2018: Journal of Obesity
Sijia Liu, Yun Qu
In view of the multiple and diversity of sleep disorders, this paper develops and designs mobile portable devices based on remote monitoring and assessment of sleep quality. Using psychological scale, the patient's vital signs, sleeping data collection, statistics, and information transfer through remote signals to self-developed software for information entry and calculation, which could objectively display the quality of patient's sleep, so that medical staff might manage the patient's sleep better. Due to the features of portable device, such as its convenient to carry about, low price and else, the remote device can provide timely and effective information to help the majority of insomnia patients sleep therapy...
May 30, 2018: Zhongguo Yi Liao Qi Xie za Zhi, Chinese Journal of Medical Instrumentation
Carlo Basile, Luigi Rossi, Carlo Lomonte
Acid-base equilibrium is a complex and vital system whose regulation is impaired in chronic kidney disease (CKD). Metabolic acidosis is a common complication of CKD. It is typically due to the accumulation of sulfate, phosphorus, and organic anions. Metabolic acidosis is correlated with several adverse outcomes, such as morbidity, hospitalization and mortality. In patients undergoing hemodialysis, acid-base homeostasis depends on many factors: net acid production, amount of alkali given by the dialysate bath, duration of interdialytic period, as well as residual diuresis, if any...
June 8, 2018: Seminars in Dialysis
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