keyword
MENU ▼
Read by QxMD icon Read
search

ELS

keyword
https://www.readbyqxmd.com/read/29244851/inhibition-of-merozoite-invasion-and-transient-de-sequestration-by-sevuparin-in-humans-with-plasmodium-falciparum-malaria
#1
Anna M Leitgeb, Prakaykaew Charunwatthana, Ronnatrai Rueangveerayut, Chirapong Uthaisin, Kamolrat Silamut, Kesinee Chotivanich, Patima Sila, Kirsten Moll, Sue J Lee, Maria Lindgren, Erik Holmer, Anna Färnert, Mpungu S Kiwuwa, Jens Kristensen, Christina Herder, Joel Tarning, Mats Wahlgren, Arjen M Dondorp
SEVERE MALARIA: Even with the best available treatment, the mortality from severe Plasmodium falciparum malaria remains high. Typical features at death are high parasite loads and obstructed micro- vasculature. Infected erythrocytes (IE) containing mature parasites bind to the host receptor heparan sulfate, which is also an important receptor for merozoite invasion. To block merozoite invasion has not previously been proposed as an adjunctive therapeutic approach but it may preclude the early expansion of an infection that else leads to exacerbated sequestration and death...
2017: PloS One
https://www.readbyqxmd.com/read/29241646/hiv-population-level-adaptation-can-rapidly-diminish-the-impact-of-a-partially-effective-vaccine
#2
Joshua T Herbeck, Kathryn Peebles, Paul T Edlefsen, Morgane Rolland, James T Murphy, Geoffrey S Gottlieb, Neil Abernethy, James I Mullins, John E Mittler, Steven M Goodreau
BACKGROUND: Development of an HIV vaccine might be essential to ending the HIV/AIDS pandemic. However, vaccines can result in the emergence and spread of vaccine-resistant strains. Indeed, analyses of breakthrough infections in the HIV phase 3 vaccine trial RV144 identified HIV genotypes with differential rates of transmission in vaccine and placebo recipients. We hypothesized that, for HIV vaccination programs based on partially effective vaccines similar to RV144, HIV adaptation will rapidly diminish the expected vaccine impact...
December 11, 2017: Vaccine
https://www.readbyqxmd.com/read/29240541/surveillance-or-metastasis-directed-therapy-for-oligometastatic-prostate-cancer-recurrence-a-prospective-randomized-multicenter-phase-ii-trial
#3
Piet Ost, Dries Reynders, Karel Decaestecker, Valérie Fonteyne, Nicolaas Lumen, Aurélie De Bruycker, Bieke Lambert, Louke Delrue, Renée Bultijnck, Tom Claeys, Els Goetghebeur, Geert Villeirs, Kathia De Man, Filip Ameye, Ignace Billiet, Steven Joniau, Friedl Vanhaverbeke, Gert De Meerleer
Purpose Retrospective studies suggest that metastasis-directed therapy (MDT) for oligorecurrent prostate cancer (PCa) improves progression-free survival. We aimed to assess the benefit of MDT in a randomized phase II trial. Patients and Methods In this multicenter, randomized, phase II study, patients with asymptomatic PCa were eligible if they had had a biochemical recurrence after primary PCa treatment with curative intent, three or fewer extracranial metastatic lesions on choline positron emission tomography-computed tomography, and serum testosterone levels > 50 ng/mL...
December 14, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29239261/white-matter-tract-integrity-an-indicator-of-axonal-pathology-after-mild-traumatic-brain-injury
#4
Sohae Chung, Els Fieremans, Xiuyuan Wang, Nuri E Kucukboyaci, Charles J Morton, James S Babb, Prin Amorapanth, Farng-Yang Foo, Dmitry S Novikov, Steven R Flanagan, Joseph F Rath, Yvonne W Lui
We seek to elucidate the underlying pathophysiology of injury sustained after mild traumatic brain injury (MTBI) using multi-shell diffusion MRI, deriving compartment-specific WM tract integrity (WMTI) metrics. WMTI allows a more biophysical interpretation of WM changes by describing microstructural characteristics in both intra- and extra-axonal environments. Thirty-two patients with MTBI within 30 days of injury and twenty-one age- and sex-matched controls were imaged on a 3T MR scanner. Multi-shell diffusion acquisition was performed with 5 b-values (250 - 2500 s/mm<sup>2</sup>) along 6 - 60 diffusion encoding directions...
December 14, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29238391/functional-impairment-and-painful-physical-symptoms-in-patients-with-major-depressive-disorder-treated-with-antidepressants-real-world-evidence-from-the-middle-east
#5
Jihyung Hong, Diego Novick, Maria Victoria Moneta, Ahmed El-Shafei, Héctor Dueñas, Josep Maria Haro
Background: The Global Burden of Disease 2010 study reported the relative size of major depressive disorder (MDD) burden to be greater in the Middle East and North Africa than anywhere else. However, little research has been carried out to examine the comparative effectiveness of antidepressants in this region. Objective: To assess and compare functioning levels in Middle Eastern patients with MDD treated with either duloxetine or a selective serotonin reuptake inhibitor (SSRI), and to examine the impacts of depression-related pain on functioning by the type of treatment...
2017: Clinical Practice and Epidemiology in Mental Health: CP & EMH
https://www.readbyqxmd.com/read/29238225/validity-and-completeness-of-rheumatoid-arthritis-diagnoses-in-the-nationwide-danbio-clinical-register-and-the-danish-national-patient-registry
#6
Else Helene Ibfelt, Jan Sørensen, Dorte V Jensen, Lene Dreyer, Berit Schiøttz-Christensen, Pia H Thygesen, Ada Colic, Johnny L Raun, Natalia Manilo, Anne Rødgaard, Uta E Poulsen, Claus Rasmussen, Torben Hansen, Babara Unger, Randi Pelck, Anita Kincses, Henrik Nordin, Tove Lorenzen, Ali Theibich, Inger Marie Jensen Hansen, Jakob Espesen, Jolanta Grydehøj, Mette Holland-Fischer, Anne Gitte Loft, Merete Lund Hetland
Objectives: In Denmark, patients with rheumatoid arthritis (RA) are registered in the nationwide clinical DANBIO quality register and the Danish National Patient Registry (DNPR). The aim was to study the validity of the RA diagnosis and to estimate the completeness of relevant RA cases in each registry. Study design and setting: Patients registered for the first time in 2011 with a diagnosis of RA were identified in DANBIO and DNPR in January 2013. For DNPR, filters were applied to reduce false-positive cases...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/29236483/biological-limitations-of-dechlorination-of-cis-dichloroethene-during-transport-in-porous-media
#7
Itza Mendoza-Sanchez, Robin L Autenrieth, Thomas J McDonald, Jeffrey A Cunningham
We applied a mathematical model to data from experimental column studies to understand the dynamics of successful and unsuccessful reductive dechlorination of chlorinated ethenes in groundwater under different flow conditions. In laboratory column experiments (reported previously), it was observed that complete dechlorination of cis-dichloroethene to ethene was sustained at high flow velocity (0.51 m/d), but that dechlorination failed at medium or low flow velocity (0.080 or 0.036 m/d). The mathematical model applied here accounts for transport of chlorinated ethenes in flowing groundwater, mass transfer of chlorinated ethenes between mobile groundwater and stationary biofilms, and diffusion and biodegradation within the biofilms...
December 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29235133/operating-on-the-self-transforming-agency-through-obesity-surgery-and-treatment
#8
Else Vogel
In this article, I describe the processes through which patients diagnosed with 'morbid obesity' become active subjects through undergoing obesity surgery and an empowerment lifestyle programme in a Dutch obesity clinic. Following work in actor-network theory and material semiotics that complicates the distinction between active and passive subjects, I trace how agency is configured and re-distributed throughout the treatment trajectory. In the clinic's elaborate care assemblage - consisting of dieticians, exercise coaches and psychologists - the person is not only actively involved in his/her own change, the subject of intervention is the self as 'actor': his/her material constitution, inclinations and feelings...
December 12, 2017: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29232560/the-effect-of-tranexamic-acid-and-gender-on-intraoperative-bleeding-in-orthognathic-surgery-a-randomized-controlled-trial
#9
Jesper Jared Secher, Johannes Jakobsen Sidelmann, Janne Ingerlsev, Jens Jørgen Thorn, Else Marie Pinholt
PURPOSE: The purpose of this randomized trial was to measure the effect of intravenously administered tranexamic acid (TXA) on intraoperative blood loss (IOB) in patients undergoing bimaxillary orthognathic surgery (OS). MATERIALS AND METHODS: The authors designed and implemented a double-blinded placebo-controlled trial composed of patients eligible for OS at the Hospital of South West Denmark (Esbjerg, Denmark) from August 2014 through September 2016. The primary predictor variable was a single intravenous dose of TXA 1 g administered preoperatively or an equivalent saline placebo...
November 21, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29232500/developmental-osteology-of-the-parafrontal-bones-of-the-sphaerodactylidae
#10
Aaron H Griffing, Juan D Daza, Jonathan C DeBoer, Aaron M Bauer
Well-resolved phylogenetic hypotheses and ontogenetic data are often necessary for investigating the evolution of structural novelty. The Sphaerodactylidae comprises 12 genera of predominantly miniaturized geckos. The genera Aristelliger and Teratoscincus are exceptions, with taxa reaching snout-to-vent lengths far exceeding those of other sphaerodactylids. These two genera possess enigmatic, supraorbital ossifications - parafrontal bones - which are encountered nowhere else among squamates. At the time of their discovery, these structures were believed to be the result of evolutionary convergence...
December 12, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29231078/do-i-really-feel-your-pain-comparing-the-effects-of-observed-and-personal-ostracism
#11
Anna Giesen, Gerald Echterhoff
It has been argued that "we feel the pain of others' ostracism as our own". However, it is unknown whether observed ostracism is as distressing as self-experienced ostracism. We conducted two studies to address this lacuna. In Study 1, participants played or observed an online ball-tossing game, in which they or a stranger were ostracized or included by others. In Study 2, participants imagined themselves or someone else being ostracized or included. Across both studies, self-experienced and observed ostracism had the same negative effect on mood...
December 1, 2017: Personality & Social Psychology Bulletin
https://www.readbyqxmd.com/read/29229735/oral-application-of-recombinant-bacillus-subtilis-spores-to-dogs-results-in-a-humoral-response-against-specific-echinococcus-granulosus-paramyosin-and-tropomyosin-antigens
#12
Cédric M Vogt, Maria Teresa Armúa-Fernández, Kurt Tobler, Monika Hilbe, Claudio Aguilar, Mathias Ackermann, Peter Deplazes, Catherine Eichwald
Bacillus subtilis is known as an endospore- and biofilm-forming bacterium with probiotic properties. We have recently developed a method for displaying heterologous proteins on the surface of B. subtilis biofilms by introducing the coding sequences of the protein of interest into the bacterial genome to generate a fusion protein linked to the C-terminus of the biofilm matrix protein TasA. Although B. subtilis is a regular component of the gut microflora, we constructed a series of recombinant B. subtilis strains that were tested for their ability to immunize dogs following oral application of the spores...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29229348/bone-morphogenetic-proteins-usage-in-anterior-lumbar-inter-body-fusion-what-else-can-go-wrong
#13
Elias Elias, Zeina Nasser, Lona Winegan, Terence Verla, Ibrahim Omeis
BACKGROUND: Bone Morphogenetic Protein (BMP) graft showed promising outcome during early phases of its use. However unreported adverse events and off label use shattered its safe profile and raised concerns regarding its indication. In 2008, the Food and Drug Administration (FDA) prohibited its use in anterior cervical spine procedures due to possibility of edema, hematoma and need of intubation. At the molecular level, BMP act as multifactorial growth factors playing a role in cartilage, heart, and bone formation...
December 8, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29227906/to-disinfect-or-not-to-disinfect-in-postharvest-research-on-the-fungal-decay-of-apple
#14
Matthias Naets, Mattias van Dael, Els Vanstreels, Dirk Daelemans, Pieter Verboven, Bart Nicolaï, Wannes Keulemans, Annemie Geeraerd
Postharvest losses of fruit and vegetables can reach up to 30%, the main cause being microbial decay. For apple fruit, mostly fungal pathogens, such as Penicillium expansum, Colletotrichum spp., Neofabraea spp. and Botrytis cinerea, are important. As such losses are unsustainable in many ways, it is necessary that research is conducted to prevent them. Generally, for plants and fruit grown under non-sterile field conditions, disinfection is carried out prior to the start of a phytopathological experiment. The motivation for this practice is the removal of background contamination so that it will not affect the experimental outcome and its interpretation...
December 6, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29225949/improving-postpartum-care-delivery-and-uptake-by-implementing-context-specific-interventions-in-four-countries-in-africa-a-realist-evaluation-of-the-missed-opportunities-in-maternal-and-infant-health-momi-project
#15
Nehla Djellouli, Sue Mann, Bejoy Nambiar, Paula Meireles, Diana Miranda, Henrique Barros, Fadima Y Bocoum, W Maurice E Yaméogo, Clarisse Yaméogo, Sylvie Belemkoabga, Halima Tougri, Abou Coulibaly, Seni Kouanda, Vernon Mochache, Omar K Mwakusema, Eunice Irungu, Peter Gichangi, Zione Dembo, Angela Kadzakumanja, Charles Vidonji Makwenda, Judite Timóteo, Misete G Cossa, Malica de Melo, Sally Griffin, Nafissa B Osman, Severiano Foia, Emilomo Ogbe, Els Duysburgh, Tim Colbourn
Postpartum care (PPC) has remained relatively neglected in many interventions designed to improve maternal and neonatal health in sub-Saharan Africa. The Missed Opportunities in Maternal and Infant Health project developed and implemented a context-specific package of health system strengthening and demand generation in four African countries, aiming to improve access and quality of PPC. A realist evaluation was conducted to enable nuanced understanding of the influence of different contextual factors on both the implementation and impacts of the interventions...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29225040/differential-neuromodulatory-role-of-endocannabinoids-in-the-rodent-trigeminal-sensory-ganglion-and-cerebral-cortex-relevant-to-pain-processing
#16
Francesca Eroli, Inge C M Loonen, Arn M J M van den Maagdenberg, Else A Tolner, Andrea Nistri
Endocannabinoids are suggested to control pain, even though their clinical use is not fully validated and the underlying mechanisms are incompletely understood. To clarify the targets of endocannabinoid actions, we studied how activation of the endocannabinoid CB1 receptor (CB1R) affects neuronal responses in two in vitro preparations of rodents, namely the trigeminal sensory ganglion (TG) in culture and a coronal slice of the cerebral cortex. On TG small-medium size neurons, we tested whether submicromolar concentrations of the endogenous CB1R agonist anandamide (AEA) modulated inhibitory GABAA receptors and excitatory ATP-gated P2X3 receptors...
December 7, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29223747/an-automated-high-throughput-system-for-phenotypic-screening-of-chemical-libraries-on-c-elegans-and-parasitic-nematodes
#17
Frederick A Partridge, Anwen E Brown, Steven D Buckingham, Nicky J Willis, Graham M Wynne, Ruth Forman, Kathryn J Else, Alison A Morrison, Jacqueline B Matthews, Angela J Russell, David A Lomas, David B Sattelle
Parasitic nematodes infect hundreds of millions of people and farmed livestock. Further, plant parasitic nematodes result in major crop damage. The pipeline of therapeutic compounds is limited and parasite resistance to the existing anthelmintic compounds is a global threat. We have developed an INVertebrate Automated Phenotyping Platform (INVAPP) for high-throughput, plate-based chemical screening, and an algorithm (Paragon) which allows screening for compounds that have an effect on motility and development of parasitic worms...
December 2, 2017: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/29222697/clinical-implications-of-rapid-eplex%C3%A2-respiratory-pathogen-panel-testing-compared-to-laboratory-developed-real-time-pcr
#18
Anneloes L van Rijn, Roel H T Nijhuis, Vincent Bekker, Geert H Groeneveld, Els Wessels, Mariet C W Feltkamp, Eric C J Claas
Rapid diagnosis of respiratory infections is of great importance for adequate isolation and treatment. Due to the batch-wise testing, laboratory-developed real-time polymerase chain reaction (PCR) assays (LDT) often result in a time to result of one day. Here, LDT was compared with rapid ePlex® Respiratory Pathogen (RP) Panel testing of GenMark Diagnostics (Carlsbad, CA, USA) with regard to time to result, installed isolation precautions, and antibacterial/antiviral treatment. Between January and March 2017, 68 specimens of 64 patients suspected of an acute respiratory infection were tested with LDT and the ePlex® RP panel...
December 8, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29222200/-everyone-thinks-it-s-someone-else-s-responsibility-training-for-sexual-health-doctors
#19
(no author information available yet)
No abstract text is available yet for this article.
December 8, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29221960/when-everything-else-fails-high-pressure-balloon-for-undilatable-lesions
#20
REVIEW
Ioannis Felekos, Grigoris V Karamasis, Antonis N Pavlidis
Heavily calcified lesions are encountered with increasing frequency during percutaneous coronary interventions (PCI). This poses a significant problem as it often leads to suboptimal stent expansion, which in turn is a major cause for stent restenosis and thrombosis. Various technologies have been developed to tackle this. The high-pressure balloon (OPN) seems to be a promising adjunct in treating undilatable lesions. In this concise mini review we highlight the use of HPB and we present the current status of technology implemented in complex PCI cases...
November 10, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
keyword
keyword
84051
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"