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https://www.readbyqxmd.com/read/28821731/stability-in-metabolic-phenotypes-and-inferred-metagenome-profiles-before-the-onset-of-colitis-induced-inflammation
#1
M Glymenaki, A Barnes, S O' Hagan, G Warhurst, A J McBain, I D Wilson, D B Kell, K J Else, S M Cruickshank
Inflammatory bowel disease (IBD) is associated with altered microbiota composition and metabolism, but it is unclear whether these changes precede inflammation or are the result of it since current studies have mainly focused on changes after the onset of disease. We previously showed differences in mucus gut microbiota composition preceded colitis-induced inflammation and stool microbial differences only became apparent at colitis onset. In the present study, we aimed to investigate whether microbial dysbiosis was associated with differences in both predicted microbial gene content and endogenous metabolite profiles...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819017/adrenocortical-carcinoma-and-succinate-dehydrogenase-gene-mutations
#2
Tobias Else, Antonio Marcondes Lerario, Jessica Everett, Lori Haymon, Deborah Wham, Michael Mullane, Tremika LeShan Wilson, Irene Rainville, Huma Rana, Andrew J Worth, Nathaniel W Snyder, Ian A Blair, Rana McKay, Kerry Kilbridge, Gary D Hammer, Justine Barletta, Anand Vaiyda
OBJECTIVE: Germline loss-of-function mutations in succinate dehydrogenase (SDHx) genes results in rare tumor syndromes that include pheochromocytoma, paraganglioma, and others. Here we report a case series of patients with adrenocortical carcinoma (ACC) that harbor SDHx germline mutations. PATIENTS AND RESULTS: We report four unrelated patients with ACC and SDHx mutations. All cases presented with Cushing syndrome and large adrenal masses that were confirmed to be ACC on pathology...
August 17, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28816119/clinical-presentation-and-management-of-dyskinetic-cerebral-palsy
#3
REVIEW
Elegast Monbaliu, Kate Himmelmann, Jean-Pierre Lin, Els Ortibus, Laura Bonouvrié, Hilde Feys, R Jeroen Vermeulen, Bernard Dan
Cerebral palsy is the most frequent cause of severe physical disability in childhood. Dyskinetic cerebral palsy (DCP) is the second most common type of cerebral palsy after spastic forms. DCP is typically caused by non-progressive lesions to the basal ganglia or thalamus, or both, and is characterised by abnormal postures or movements associated with impaired tone regulation or movement coordination. In DCP, two major movement disorders, dystonia and choreoathetosis, are present together most of the time. Dystonia is often more pronounced and severe than choreoathetosis, with a major effect on daily activity, quality of life, and societal participation...
September 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28815051/the-relationship-between-emotional-labor-status-and-workplace-violence-among-toll-collectors
#4
Yosub Joo, Jeongbae Rhie
BACKGROUND: This study aimed to identify the emotional labor and workplace violence status among toll collectors by assessing and comparing the same with that in workers in other service occupation. It also aimed to analyze the relationship between emotional labor and workplace violence. METHODS: This study examined emotional labor and workplace violence status in 264 female toll collectors from August 20 to September 4, 2015. The emotional labor was assessed using the Korean Emotional Labor Scale (K-ELS), and a questionnaire was used to examine the presence or absence, and type and frequency of workplace violence experienced by the subjects...
2017: Annals of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28810423/psychological-factors-addressed-in-cognitive-behaviour-therapy-for-paediatric-functional-abdominal-pain-which-are-most-important-to-target
#5
Shelley Mc van der Veek, Else de Haan, Hhf Derkx, Marc A Benninga, Frits Boer
The effectiveness of cognitive behaviour therapy for paediatric functional abdominal pain leaves room for improvement. We studied which factors addressed in cognitive behaviour therapy relate most strongly to the physical and psychological functioning of children with functional abdominal pain and are thus most important to target. Questionnaires were filled out by 117 children with functional abdominal pain and their parents. Multiple regression analyses showed that children's passive coping and parental and children's positive cognitions relate to child functioning...
February 1, 2017: Journal of Health Psychology
https://www.readbyqxmd.com/read/28806445/use-of-laboratory-markers-in-addition-to-symptoms-for-diagnosis-of-inflammatory-bowel-disease-in-children-a-meta-analysis-of-individual-patient-data
#6
Gea A Holtman, Yvonne Lisman-van Leeuwen, Andrew S Day, Ulrika L Fagerberg, Paul Henderson, Stevan T Leach, Gøri Perminow, David Mack, Patrick F van Rheenen, Els van de Vijver, David C Wilson, Johannes B Reitsma, Marjolein Y Berger
Importance: Blood markers and fecal calprotectin are used in the diagnostic workup for inflammatory bowel disease (IBD) in pediatric patients. Any added diagnostic value of these laboratory markers remains unclear. Objective: To determine whether adding laboratory markers to evaluation of signs and symptoms improves accuracy when diagnosing pediatric IBD. Data Sources: A literature search of MEDLINE and EMBASE from inception through September 26, 2016...
August 14, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28806418/seasonality-affects-dietary-diversity-of-school-age-children-in-northern-ghana
#7
Abdul-Razak Abizari, Fusta Azupogo, Miwako Nagasu, Noortje Creemers, Inge D Brouwer
BACKGROUND AND OBJECTIVES: Dietary diversity score (DDS) is relatively easy to measure and is shown to be a very useful indicator of the probability of adequate micronutrient intake. Dietary diversity, however, is usually assessed during a single period and little is known about the effect of seasonality on it. This study investigates whether dietary diversity is influenced by seasonality. METHODS: Two cross-sectional surveys were conducted in two different seasons-dry season (October 2010) and rainy season (May 2011) among the same school-age children (SAC) in two rural schools in northern Ghana...
2017: PloS One
https://www.readbyqxmd.com/read/28805158/pp2a-regulatory-subunit-b55%C3%AE-is-a-gatekeeper-of-osteoblast-maturation-and-lineage-maintenance
#8
Anastassia Serguienko, Robert Hanes, Iwona Grad, Meng-Yu Wang, Ola Myklebost, Else Munthe
Bone marrow mesenchymal stem cells (BM MSCs) mediate skeletal remodeling by differentiating into osteoblasts. However, this remodeling is impaired with aging as well as following long-term glucocorticoid treatment, resulting in osteoporosis. Here we report a novel factor of osteoblast differentiation - PP2A regulatory subunit B55γ. We show that B55γ is induced by glucocorticoid receptor (GR) in human primary BM MSCs during differentiation to osteoblast, but not to adipocytes, and is required for osteoblast morphogenesis and mineralization...
August 12, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28804980/using-bayes-factors-to-evaluate-evidence-for-no-effect-examples-from-the-sips-project
#9
Zoltan Dienes, Simon Coulton, Nick Heather
AIMS: To illustrate how Bayes Factors are important for determining the effectiveness of interventions. METHOD: We consider a case where inappropriate conclusions were publicly drawn based on significance testing, namely the SIPS Project (Screening and Intervention Programme for Sensible drinking), a pragmatic, cluster-randomized controlled trial in each of two healthcare settings and in the criminal justice system. We show how Bayes Factors can disambiguate the non-significant findings from the SIPS Project and thus determine whether the findings represent evidence of absence or absence of evidence...
August 13, 2017: Addiction
https://www.readbyqxmd.com/read/28804837/detection-and-measurement-of-factor-inhibitors
#10
Geoffrey Kershaw
Specific coagulation factor inhibitors, most notably to coagulation factor VIII, can develop in patients with hemophilia after exposure to replacement factor or as an acquired (autoimmune) event. Such inhibitors can be detected by a combination of prolonged coagulation screening tests, such as the activated partial thromboplastin time, plus a non-correcting mixing test. Non-correction may only be evident, or else may be extenuated, with incubation at 37 °C. The Bethesda assay for quantitation of inhibitor strength is based on a combination of mixing tests followed by specific factor assays...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28800763/causes-trends-and-severity-of-musculoskeletal-injuries-in-ghana
#11
Eric Lawer Torgbenu, Emmanuel K Nakua, Henry Kyei, Eric Badu, Maxwell Peprah Opoku
BACKGROUND: Musculoskeletal [MSK] injuries are common causes of long-term pain and physical disability which affect many people worldwide. The economic and social impacts on the individual, society and national health systems are enormous making a matter of public health concern. Therefore, this study examined the causes and extent of MSK injuries in a referral hospital in Ghana. METHODS: A prospective study design with consecutive sampling method was used to recruit patients admitted at Trauma Unit as well as those receiving orthopaedic reviews at St...
August 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28799478/researching-health-care-as-a-meaningful-practice-toward-a-nondualistic-view-on-evidence-for-qualitative-research
#12
Els van Wijngaarden, Hanneke van der Meide, Karin Dahlberg
Being able to describe how research findings become evidence is crucial in providing a justification for all kinds of research findings. However, qualitative researchers in health care, including those who conduct phenomenological research, are usually fairly modest when it comes qualifying their research findings as such. We advocate a view of evidence for phenomenological research, an approach that is rooted in philosophy of science, including perspectives of ontology, epistemology, and methodology. We suggest that phenomenology can become an exemplar for how qualitative research can make convincing arguments and thus can be better appreciated...
September 2017: Qualitative Health Research
https://www.readbyqxmd.com/read/28799283/selection-and-transfer-of-an-inci1-tet-a-plasmid-of-escherichia-coli-in-an-ex-vivo-model-of-the-porcine-cecum-at-doxycycline-concentrations-caused-by-cross-contaminated-feed
#13
Laura E J Peeters, Thijs De Mulder, Els Van Coillie, Judith Huygens, Annemieke Smet, Els Daeseleire, Jeroen Dewulf, Hein Imberechts, Patrick Butaye, Freddy Haesebrouck, Siska Croubels, Marc Heyndrickx, Geertrui Rasschaert
AIMS: The aim of this study was to investigate the effect of subtherapeutic intestinal doxycycline (DOX) concentrations (4 and 1 mg l(-1) ), caused by cross-contamination of feed, on the enrichment of a DOX resistant commensal E. coli and it's resistance plasmid in an ex vivo model of the porcine cecum. METHODS AND RESULTS: A DOX resistant, tet(A) carrying, porcine commensal E. coli strain (EC 682) was cultivated for 6 days in the porcine cecum model under different conditions (0, 1 and 4 mg l(-1) DOX)...
August 11, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28797946/genome-wide-screening-of-oryza-sativa-ssp-japonica-and-indica-reveals-a-complex-family-of-proteins-with-ribosome-inactivating-protein-domains
#14
Pieter Wytynck, Pierre Rougé, Els J M Van Damme
Ribosome-inactivating proteins (RIPs) are cytotoxic enzymes capable of halting protein synthesis by irreversible modification of ribosomes. Although RIPs are widespread they are not ubiquitous in the plant kingdom. The physiological importance of RIPs is not fully elucidated, but evidence suggests a role in the protection of the plant against biotic and abiotic stresses. Searches in the rice genome revealed a large and highly complex family of proteins with a RIP domain. A comparative analysis retrieved 38 RIP sequences from the genome sequence of Oryza sativa subspecies japonica and 34 sequences from the subspecies indica...
August 7, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28795142/plasma-proenkephalin-and-poor-long-term-outcome-in-renal-transplant-recipients
#15
Lyanne M Kieneker, Oliver Hartmann, Joachim Struck, Andreas Bergmann, Ron T Gansevoort, Michel M Joosten, Else van den Berg, Rudolf A de Boer, Stephan J L Bakker
BACKGROUND: Proenkephalin (pro-ENK), a stable and reliable surrogate marker for unstable enkephalins, was found to be associated with acute kidney injury and chronic renal failure in previous studies. We aimed to investigate whether pro-ENK is linked to chronic kidney injury and poor long-term outcome in renal transplant recipients (RTR). METHODS: We included 664 stable RTR and 95 healthy kidney donors. Pro-ENK was measured in plasma with a double monoclonal sandwich immunoassay...
August 2017: Transplantation Direct
https://www.readbyqxmd.com/read/28792324/being-trained-to-deal-with-extremism
#16
Gabrielle Hunt
Nowhere in our studies are we trained in any similar way to the police, armed forces or anyone else who are specifically trained to deal with extremism.
August 9, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28783886/cerebrospinal-vascular-diseases-misdiagnosed-as-decompression-illness-the-importance-of-considering-other-neurological-diagnoses
#17
Kiyotaka Kohshi, Yoshitaka Morimatsu, Hideki Tamaki, Yukio Murata, Katsuko Kohshi, Tatsuya Ishitake, Petar J Denoble
The diagnosis of decompression illness (DCI), which is based on a history of decompression and clinical findings, can sometimes be confounded with other vascular events of the central nervous system. The authors report three cases of divers who were urgently transported to a hyperbaric facility for hyperbaric oxygen treatment of DCI which at admission turned out to be something else. The first case, a 45-year-old experienced diver with unconsciousness, was clinically diagnosed as having experienced subarachnoid hemorrhage, which was confirmed by CT scan...
July 2017: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
https://www.readbyqxmd.com/read/28780573/atrial-fibrillation-and-menopause-something-else-to-worry-about-or-not
#18
EDITORIAL
Emily N Guhl, Jared W Magnani
No abstract text is available yet for this article.
August 5, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28777733/who-does-not-cut-down-comparing-characteristics-and-drinking-motives-of-drinkers-and-abstainers-during-the-exam-periods
#19
Joris Van Damme, Anne Hublet, Bart De Clercq, Emmanuel Kuntsche, Lea Maes, Els Clays
OBJECTIVE: Drinking alcohol during the exams can affect academic performance and future career options, but is rarely investigated. Drinking motives, socio-demographics and personality characteristics are investigated in non-abstainers and weekly drinkers during the exams. PARTICIPANTS: 7,181 Belgian university students who anonymously responded to an email invitation to an online survey. METHODS: Logistic regressions and mixed design analysis-of-variance on cross-sectional data...
August 4, 2017: Journal of American College Health: J of ACH
https://www.readbyqxmd.com/read/28777317/type-and-context-of-alcohol-related-injury-among-patients-presenting-to-emergency-departments-in-a-caribbean-country
#20
Sandra D Reid, Jannel Gentius
There is an association between alcohol consumption and injuries in Latin America and the Caribbean. This cross-sectional study explores the socio-contextual factors of alcohol-related injuries in Trinidad and Tobago. Data on drinking patterns, injury type, drinking context prior to injury, and demographics were collected from patients presenting with injuries to the Emergency Departments (ED) of four hospitals. Findings show that 20.6% of patients had consumed alcohol, mainly beer, in the 6 h before injury...
August 4, 2017: International Journal of Environmental Research and Public Health
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