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https://www.readbyqxmd.com/read/29471274/accession-specific-life-strategies-affect-responses-in-leaves-of-arabidopsis-thaliana-plants-exposed-to-excess-cu-and-cd
#1
Rafaela Amaral Dos Reis, Els Keunen, Miguel Pedro Mourato, Luísa Louro Martins, Jaco Vangronsveld, Ann Cuypers
The natural accession Columbia (Col-0) is considered as the reference genome of the model plant Arabidopsis thaliana. Nonetheless, Col-0 plants are more sensitive to excess copper (Cu) and cadmium (Cd) than other widely used accessions such as Wassilewskija (Ws) plants. In the current study, this accession-specific metal sensitivity is further explored by comparing the responses in leaves of Col-0 and Ws plants exposed to excess Cu and Cd. Our results suggest that different life strategies favored by both accessions under physiological conditions affect their response to metal exposure...
February 6, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29470388/adolescents-sexual-wellbeing-in-southwestern-uganda-a-cross-sectional-assessment-of-body-image-self-esteem-and-gender-equitable-norms
#2
Elizabeth Kemigisha, Viola N Nyakato, Katharine Bruce, Gad Ndaruhutse Ruzaaza, Wendo Mlahagwa, Anna B Ninsiima, Gily Coene, Els Leye, Kristien Michielsen
Measures of sexual wellbeing and positive aspects of sexuality in the World Health Organization definition for sexual health are rarely studied and remain poorly understood, especially among adolescents in Sub-Saharan Africa. The objective of this study was to assess sexual wellbeing in its broad sense-i.e., body image, self-esteem, and gender equitable norms-and associated factors in young adolescents in Uganda. A cross-sectional survey of adolescents ages 10-14 years in schools was carried out between June and July 2016...
February 22, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29469969/nanobody-enabled-reverse-pharmacology-on-gpcrs
#3
Els Pardon, Cecilia Betti, Toon Laeremans, Florent Chevillard, Karel Guillemyn, Peter Kolb, Steven Ballet, Jan Steyaert
The conformational complexity of G protein-coupled receptor (GPCR) transmembrane signaling is a central hurdle for the design of screens for receptor agonists. In their basal states, GPCRs have lower affinities for agonists compared to their G protein-bound active state conformations. Moreover, different agonists can stabilize distinct active receptor conformations and do not uniformly activate all cellular signaling pathways linked to a given receptor (agonist bias). Herein, comparative fragment screens were performed on a β2 adrenoreceptor-Nanobody fusion locked in its active state conformation by a G protein mimicking Nanobody, and the same receptor in its basal state conformation...
February 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29464830/dietary-approach-to-stop-hypertension-dash-diet-and-risk-of-renal-function-decline-and-all-cause-mortality-in-renal-transplant-recipients
#4
Maryse C J Osté, António W Gomes-Neto, Eva Corpeleijn, Rijk O B Gans, Martin H de Borst, Else van den Berg, Sabita S Soedamah-Muthu, Daan Kromhout, Gerjan J Navis, Stephan J L Bakker
Renal transplant recipients (RTR) are at risk of decline of graft function and premature mortality, with high blood pressure as important risk factor for both. To study the association of the Dietary Approach to Stop Hypertension (DASH) diet with these adverse events, we conducted a prospective cohort study of adult RTR. Dietary data was collected using a validated 177-item food frequency questionnaire and an overall DASH-score was obtained. We included 632 stable RTR (mean±SD age: 53.0±12.7 y, 57% men). Mean DASH score was 23...
February 21, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29464826/international-continence-society-supported-pelvic-physiotherapy-education-guideline
#5
Els Bakker, Beth Shelly, Fetske H Esch, Helena Frawley, Doreen McClurg, Peter Meyers
AIM: To provide a guideline of desired knowledge, clinical skills and education levels in Pelvic Physiotherapy (PT). Physiotherapy (PT) involves "using knowledge and skills unique to physiotherapists" and, "is the service only provided by, or under the direction and supervision of a physiotherapist."1 METHODS: The PT Committee, within the body of the International Continence Society (ICS), collected information regarding existing educational levels for pelvic floor PT...
February 21, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29464545/extra-mucosal-enucleation-is-still-a-safe-and-feasible-treatment-option-of-giant-esophageal-leiomyomas
#6
Azhar Perwaiz, Vinay Kumar Shaw, Amanjeet Singh, Adarsh Chaudhary
Esophageal leiomyoma (EL) is rare but still the most common benign tumor of the esophagus. Extra-mucosal enucleation (EME) is the treatment of choice. Many recent reports have favored esophageal resection for giant Esophageal leiomyomas (ELs). The consequence of esophageal resection is well known and it would be radical to consider it as a preferred treatment for giant EL since most of them are still benign. We share case series of five giant ELs managed by EME, avoiding a mucosal breach and hence avoiding potentially morbid esophageal resections...
February 21, 2018: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
https://www.readbyqxmd.com/read/29463886/a-set-of-regulatory-genes-co-expressed-in-embryonic-human-brain-is-implicated-in-disrupted-speech-development
#7
Else Eising, Amaia Carrion-Castillo, Arianna Vino, Edythe A Strand, Kathy J Jakielski, Thomas S Scerri, Michael S Hildebrand, Richard Webster, Alan Ma, Bernard Mazoyer, Clyde Francks, Melanie Bahlo, Ingrid E Scheffer, Angela T Morgan, Lawrence D Shriberg, Simon E Fisher
Genetic investigations of people with impaired development of spoken language provide windows into key aspects of human biology. Over 15 years after FOXP2 was identified, most speech and language impairments remain unexplained at the molecular level. We sequenced whole genomes of nineteen unrelated individuals diagnosed with childhood apraxia of speech, a rare disorder enriched for causative mutations of large effect. Where DNA was available from unaffected parents, we discovered de novo mutations, implicating genes, including CHD3, SETD1A and WDR5...
February 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29458389/artesunate-shows-potent-anti-tumor-activity-in-b-cell-lymphoma
#8
Thea Kristin Våtsveen, Marit Renée Myhre, Chloé Beate Steen, Sébastien Wälchli, Ole Christian Lingjærde, Baoyan Bai, Pierre Dillard, Theodossis A Theodossiou, Toril Holien, Anders Sundan, Else Marit Inderberg, Erlend B Smeland, June Helen Myklebust, Morten P Oksvold
BACKGROUND: Although chemo-immunotherapy has led to an improved overall survival for most B-cell lymphoma types, relapsed and refractory disease remains a challenge. The malaria drug artesunate has previously been identified as a growth suppressor in some cancer types and was tested as a new treatment option in B-cell lymphoma. METHODS: We included artesunate in a cancer sensitivity drug screen in B lymphoma cell lines. The preclinical properties of artesunate was tested as single agent in vitro in 18 B-cell lymphoma cell lines representing different histologies and in vivo in an aggressive B-cell lymphoma xenograft model, using NSG mice...
February 20, 2018: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/29457244/the-different-moral-bases-of-patient-and-surrogate-decision-making
#9
Daniel Brudney
My topic is a problem with our practice of surrogate decision-making in health care, namely, the problem of the surrogate who is not doing her job-the surrogate who cannot be reached or the surrogate who seems to refuse to understand or to be unable to understand the clinical situation. The analysis raises a question about the surrogate who simply disagrees with the medical team. One might think that such a surrogate is doing her job-the team just doesn't like how she is doing it. My analysis raises the question of whether (or perhaps when) she should be overridden...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29457235/the-intimate-responsibility-of-surrogate-decision-making
#10
Hilde Lindemann
Daniel Brudney's clear-headed analysis, in this issue of the Hastings Center Report, of the difference between a patient's and a surrogate's right to make medical treatment decisions contributes to a longstanding conversation in bioethics. Brudney offers an epistemological and a moral argument for the patient's and the surrogate's right to decide. The epistemological argument is the same for both parties: the (competent) patient has a right to decide because she is presumed to know her own interests better than anyone else, and the surrogate is entitled to make decisions because she knows the patient better than anyone else...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29456782/other-people-s-money-the-role-of-reciprocity-and-social-uncertainty-in-decisions-for-others
#11
Ivo Vlaev, Brian Wallace, Nicholas Wright, Antoinette Nicolle, Paul Dolan, Raymond Dolan
Many important decisions are taken not by the person who will ultimately gain or lose from the outcome, but on their behalf, by somebody else. We examined economic decision-making about risk and time in situations in which deciders chose for others who also chose for them. We propose that this unique setting, which has not been studied before, elicits perception of reciprocity that prompts a unique bias in preferences. We found that decision-makers are less patient (more discounting), and more risk averse for losses than gains, with other peoples' money, especially when their choices for others are more uncertain...
June 2017: Journal of Neuroscience, Psychology, and Economics
https://www.readbyqxmd.com/read/29455161/assessing-factors-associated-with-long-term-work-disability-after-cancer-in-belgium-a-population-based-cohort-study-using-competing-risks-analysis-with-a-7-year-follow-up
#12
Régine Levo Kiasuwa Mbengi, Alina Mioara Nicolaie, Els Goetghebeur, Renee Otter, Katrien Mortelmans, Sarah Missinnne, Marc Arbyn, Catherine Bouland, Christophe de Brouwer
OBJECTIVES: The number of workers with cancer has dramatically increasing worldwide. One of the main priorities is to preserve their quality of life and the sustainability of social security systems. We have carried out this study to assess factors associated with the ability to work after cancer. Such insight should help with the planning of rehabilitation needs and tailored programmes. PARTICIPANTS: We conducted this register-based cohort study using individual data from the Belgian Disability Insurance...
February 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29453439/working-memory-and-brain-tissue-microstructure-white-matter-tract-integrity-based-on-multi-shell-diffusion-mri
#13
Sohae Chung, Els Fieremans, Nuri E Kucukboyaci, Xiuyuan Wang, Charles J Morton, Dmitry S Novikov, Joseph F Rath, Yvonne W Lui
Working memory is a complex cognitive process at the intersection of sensory processing, learning, and short-term memory and also has a general executive attention component. Impaired working memory is associated with a range of neurological and psychiatric disorders, but very little is known about how working memory relates to underlying white matter (WM) microstructure. In this study, we investigate the association between WM microstructure and performance on working memory tasks in healthy adults (right-handed, native English speakers)...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453254/development-of-a-versatile-cas9-driven-subpopulation-selection-toolbox-in-lactococcus-lactis
#14
Simon van der Els, Jennelle K James, Michiel Kleerebezem, Peter A Bron
CRISPR-Cas9 technology has been exploited for the removal or replacement of genetic elements in a wide range of prokaryotes and eukaryotes. Here we describe the extension of the Cas9 application toolbox to the industrially important dairy species Lactococcus lactis The Cas9 expression vector pLABTarget was constructed, encoding the Streptocccus pyogenes Cas9 under control of a constitutive promoter, and allowing plug and play introduction of sgRNA sequences to target specific genetic loci. Introduction of a pepN -targeting derivative of pLABTarget into L...
February 16, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29451777/filomicelles-deliver-a-chemo-differentiation-combination-of-paclitaxel-and-retinoic-acid-that-durably-represses-carcinomas-in-liver-to-prolong-survival
#15
Praful Nair, Cory Alvey, Xiaoling Jin, Jerome Irianto, Irena Ivanovska, Dennis E Discher
Drug resistance and relapse is common in cancer treatments with chemotherapeutics, and while drug combinations with naturally occurring, differentiation-inducing retinoic acid (RA) are highly successful against one type of liquid tumor, solid tumors present major problems for delivery. Here, inspired by filoviruses that can be microns in length, flexible filomicelles that self-assemble from an amphiphilic block copolymer (PEG-PCL) are shown to effectively deliver RA and paclitaxel (TAX) to several solid tumor models, particularly in liver...
February 16, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29450663/children-s-doctor-games-and-nudity-at-danish-childcare-institutions
#16
Else-Marie Buch Leander, Per Lindsø Larsen, Karen Pallesgaard Munk
This article presents the first Danish study of the acceptance of children's nudity and sexuality at Danish childcare institutions. The study revealed an important cultural shift in the attitude toward children's nudity and sexual games, the so-called doctor games. Although these were quite accepted at Danish childcare institutions until the beginning of this century, the study showed that new, pervasive regulations had been established to control the child's body and its sexuality. A new discourse revealed that fear of child sexual abuse, in particular, had influenced views of children's sexual games and nudity and that, at times, the child itself was viewed as a potential threat to other children...
February 15, 2018: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29449937/thermal-decomposition-of-the-amino-acids-glycine-cysteine-aspartic-acid-asparagine-glutamic-acid-glutamine-arginine-and-histidine
#17
Ingrid M Weiss, Christina Muth, Robert Drumm, Helmut O K Kirchner
Background: The pathways of thermal instability of amino acids have been unknown. New mass spectrometric data allow unequivocal quantitative identification of the decomposition products. Results: Calorimetry, thermogravimetry and mass spectrometry were used to follow the thermal decomposition of the eight amino acids G, C, D, N, E, Q, R and H between 185 °C and 280 °C. Endothermic heats of decomposition between 72 and 151 kJ/mol are needed to form 12 to 70% volatile products...
2018: BMC Biophysics
https://www.readbyqxmd.com/read/29447206/multiplex-crispr-cas9-system-impairs-hcmv-replication-by-excising-an-essential-viral-gene
#18
Janina Gergen, Flora Coulon, Alison Creneguy, Nathan Elain-Duret, Alejandra Gutierrez, Olaf Pinkenburg, Els Verhoeyen, Ignacio Anegon, Tuan Huy Nguyen, Franck Albert Halary, Fabienne Haspot
Anti-HCMV treatments used in immunosuppressed patients reduce viral replication, but resistant viral strains can emerge. Moreover, these drugs do not target latently infected cells. We designed two anti-viral CRISPR/Cas9 strategies to target the UL122/123 gene, a key regulator of lytic replication and reactivation from latency. The singleplex strategy contains one gRNA to target the start codon. The multiplex strategy contains three gRNAs to excise the complete UL122/123 gene. Primary fibroblasts and U-251 MG cells were transduced with lentiviral vectors encoding Cas9 and one or three gRNAs...
2018: PloS One
https://www.readbyqxmd.com/read/29447178/joint-ancestry-and-association-test-indicate-two-distinct-pathogenic-pathways-involved-in-classical-dengue-fever-and-dengue-shock-syndrome
#19
Marisa Oliveira, Worachart Lert-Itthiporn, Bruno Cavadas, Verónica Fernandes, Ampaiwan Chuansumrit, Orlando Anunciação, Isabelle Casademont, Fanny Koeth, Marina Penova, Kanchana Tangnararatchakit, Chiea Chuen Khor, Richard Paul, Prida Malasit, Fumihiko Matsuda, Etienne Simon-Lorière, Prapat Suriyaphol, Luisa Pereira, Anavaj Sakuntabhai
Ethnic diversity has been long considered as one of the factors explaining why the severe forms of dengue are more prevalent in Southeast Asia than anywhere else. Here we take advantage of the admixed profile of Southeast Asians to perform coupled association-admixture analyses in Thai cohorts. For dengue shock syndrome (DSS), the significant haplotypes are located in genes coding for phospholipase C members (PLCB4 added to previously reported PLCE1), related to inflammation of blood vessels. For dengue fever (DF), we found evidence of significant association with CHST10, AHRR, PPP2R5E and GRIP1 genes, which participate in the xenobiotic metabolism signaling pathway...
February 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29444675/current-and-future-distribution-of-aedes-aegypti-and-aedes-albopictus-diptera-culicidae-in-who-eastern-mediterranean-region
#20
Els Ducheyne, Nhu Nguyen Tran Minh, Nabil Haddad, Ward Bryssinckx, Evans Buliva, Frédéric Simard, Mamunur Rahman Malik, Johannes Charlier, Valérie De Waele, Osama Mahmoud, Muhammad Mukhtar, Ali Bouattour, Abdulhafid Hussain, Guy Hendrickx, David Roiz
BACKGROUND: Aedes-borne diseases as dengue, zika, chikungunya and yellow fever are an emerging problem worldwide, being transmitted by Aedes aegypti and Aedes albopictus. Lack of up to date information about the distribution of Aedes species hampers surveillance and control. Global databases have been compiled but these did not capture data in the WHO Eastern Mediterranean Region (EMR), and any models built using these datasets fail to identify highly suitable areas where one or both species may occur...
February 14, 2018: International Journal of Health Geographics
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