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https://www.readbyqxmd.com/read/28449310/rational-design-of-nanobody80-loop-peptidomimetics-towards-biased-%C3%AE-2-adrenergic-receptor-ligands
#1
Charlotte Martin, Samuel Moors, Mia Danielsen, Cecilia Betti, Cecilia Fabris, Daniel Sejer Pedersen, Els Pardon, Marion Peyressatre, Krisztina Fehér, Jose C Martins, Jesper Mosolff Mathiesen, May Morris, Nick Devoogdt, Vicky Caveliers, Frank De Proft, Jan Steyaert, Steven Ballet
G protein-coupled receptors (GPCRs) play an important role for many cellular responses, and as such their mechanism of action is of utmost interest. To gain insight into the active conformation of GPCRs, the X-ray crystal structures of Nanobody(Nb)-stabilized β2-adrenergic receptor (β2AR) have been reported. Nb80 in particular is able to bind the intracellular G protein binding site of β2AR and stabilize the receptors in an active conformation. Within Nb80, the complementarity-determining region 3 (CDR3) is responsible for most of the binding interactions...
April 27, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28448389/long-term-results-after-oncoplastic-surgery-for-breast-cancer-a-10-year-follow-up
#2
Krishna B Clough, Raquel F D van la Parra, Helene H Thygesen, Eric Levy, Elisabeth Russ, Najeeb M Halabi, Isabelle Sarfati, Claude Nos
OBJECTIVE: The aim of this study was to evaluate the long-term oncologic outcome after oncoplastic surgery (OPS). BACKGROUND: OPS combines wide tumor excision with reduction mammoplasty techniques thus extending breast conserving surgery to large tumors that might else be proposed a mastectomy. Little data are available about the oncologic results for breast conserving surgery of these larger tumors. METHODS: From January 2004 until March 2016, a total of 350 oncoplastic breast reductions were prospectively entered into a database...
April 26, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28447919/postpartum-dyspareunia-and-sexual-functioning-a-prospective-cohort-study
#3
Liesbet Lagaert, Steven Weyers, Helena Van Kerrebroeck, Els Elaut
OBJECTIVES: Sexual functioning is an important concern for women in the postpartum period. The aim of this research was to investigate the prevalence and determinants of dyspareunia and sexual dysfunction before and after childbirth. METHODS: Between November 2013 and April 2014, 109 women in their third trimester of pregnancy were enrolled in a prospective cohort study at Ghent University Hospital. Dyspareunia, sexual functioning and quality of life (QOL) were evaluated at enrolment and again 6 weeks and 6 months postpartum...
April 27, 2017: European Journal of Contraception & Reproductive Health Care
https://www.readbyqxmd.com/read/28446674/broadening-cd4-and-cd8-t-cell-responses-against-hepatitis-c-virus-by-vaccination-with-ns3-overlapping-peptide-panels-in-cross-priming-liposomes
#4
Jonathan Filskov, Marianne Mikkelsen, Paul R Hansen, Jan P Christensen, Allan R Thomsen, Peter Andersen, Jens Bukh, Else Marie Agger
Despite the introduction of effective drugs to treat patients with chronic hepatitis C virus (HCV) infection, a vaccine would be the only means to substantially reduce the worldwide disease burden. An incomplete understanding of how HCV interacts with its human host and evades immune surveillance has hampered vaccine development. It is generally accepted that in infected individuals, a narrow repertoire of exhausted T cells is a hallmark of persistent infection, whereas broad vigorous CD4(+) and CD8(+) T cell responses are associated with control of acute hepatitis C...
April 26, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28443437/how-nurses-can-improve-quality-while-controlling-costs
#5
Caroline Shuldham
Health care is expensive, and nurses, like everyone else, must use resources responsibly. At the start of a new financial year there is usually a focus on budgets: how much was spent last year, what is available for next year and how savings will be made.
April 26, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28442164/if-you-want-to-make-an-important-discovery-listen-to-your-patients
#6
EDITORIAL
Patrick C Walsh
No one knows more about certain aspects of a disease than the patient who has it. So, listen to your patients and they may lead you in a direction in which no one else is going.
April 22, 2017: European Urology
https://www.readbyqxmd.com/read/28440685/work-environment-an-opportunity-for-ground-breaking-collaborations-in-cardiovascular-disease-prevention
#7
Marco M Ferrario, Paul Landsbergis, Akizumi Tsutsumi, Jian Li, Pikhart Hynek, Niklas Krause, Peter Smith, Andreas Holtermann, And Els Clays
No abstract text is available yet for this article.
May 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28439403/policy-entrepreneurship-and-policy-networks-in-healthcare-systems-the-case-of-israel-s-pediatric-dentistry-reform
#8
Nissim Cohen, Tuvia Horev
BACKGROUND: Can the entry of a policy entrepreneur challenge the equilibrium of a policy network and promote changes that might clash with the goals of powerful civil-servants and/or interest groups and, if so, why and how? Our goal is to examine two sides of the same coin: how does an in-depth analysis of Israel's dental care reform enrich our understanding of policy networks and policy entrepreneurship? Second, how does the literature on policy networks and policy entrepreneurship help us understand this reform? Based on a theoretical framework that appears in the literature of policy entrepreneurship and policy networks, we analyze the motivations, goals and strategies of the main actors involved in the process of reforming pediatric dental care in Israel...
2017: Israel Journal of Health Policy Research
https://www.readbyqxmd.com/read/28429761/a-specific-nanobody-prevents-amyloidogenesis-of-d76n-%C3%AE-2-microglobulin-in-vitro-and-modifies-its-tissue-distribution-in-vivo
#9
Sara Raimondi, Riccardo Porcari, P Patrizia Mangione, Guglielmo Verona, Julien Marcoux, Sofia Giorgetti, Graham W Taylor, Stephan Ellmerich, Maurizio Ballico, Stefano Zanini, Els Pardon, Raya Al-Shawi, J Paul Simons, Alessandra Corazza, Federico Fogolari, Manuela Leri, Massimo Stefani, Monica Bucciantini, Julian D Gillmore, Philip N Hawkins, Maurizia Valli, Monica Stoppini, Carol V Robinson, Jan Steyaert, Gennaro Esposito, Vittorio Bellotti
Systemic amyloidosis is caused by misfolding and aggregation of globular proteins in vivo for which effective treatments are urgently needed. Inhibition of protein self-aggregation represents an attractive therapeutic strategy. Studies on the amyloidogenic variant of β2-microglobulin, D76N, causing hereditary systemic amyloidosis, have become particularly relevant since fibrils are formed in vitro in physiologically relevant conditions. Here we compare the potency of two previously described inhibitors of wild type β2-microglobulin fibrillogenesis, doxycycline and single domain antibodies (nanobodies)...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429177/learning-from-one-s-own-errors-and-those-of-others
#10
Janet Metcalfe, Judy Xu
Three experiments investigated the effects of making errors oneself, as compared to just hearing the correct answer without error generation, hearing another person make an error, or being "on-the-hook," that is, possibly but not necessarily being the person who would be "called-on" to give a response. In all three experiments, generating either an error of commission or generating the correct response, oneself, out loud, compared to being a person who heard another's commission errors (or correct responses), was beneficial for later recall of the correct answer...
April 20, 2017: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/28428762/gendered-pathways-how-mathematics-ability-beliefs-shape-secondary-and-postsecondary-course-and-degree-field-choices
#11
REVIEW
Lara Perez-Felkner, Samantha Nix, Kirby Thomas
Do mathematics ability beliefs explain gender gaps in the physical science, engineering, mathematics, and computer science fields (PEMC) and other science fields? We leverage U.S. nationally representative longitudinal data to estimate gendered differences in girls' and boys' perceptions of mathematics ability with the most difficult or challenging material. Our analyses examine the potentially interacting effects of gender and these ability beliefs on students' pathways to scientific careers. Specifically, we study how beliefs about ability with challenging mathematics influence girls' and boys' choices to pursue PEMC degrees, evaluating educational milestones over a 6-year period: advanced science course completion in secondary school and postsecondary major retention and selection...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28427904/leishmania-donovani-tyrosyl-trna-synthetase-structure-in-complex-with-a-tyrosyl-adenylate-analog-and-comparisons-with-human-and-protozoan-counterparts
#12
Ximena Barros-Álvarez, Keshia M Kerchner, Cho Yeow Koh, Stewart Turley, Els Pardon, Jan Steyaert, Ranae M Ranade, J Robert Gillespie, Zhongsheng Zhang, Christophe L M J Verlinde, Erkang Fan, Frederick S Buckner, Wim G J Hol
The crystal structure of Leishmania donovani tyrosyl-tRNA synthetase (LdTyrRS) in complex with a nanobody and the tyrosyl adenylate analog TyrSA was determined at 2.75 Å resolution. Nanobodies are the variable domains of camelid heavy chain-only antibodies. The nanobody makes numerous crystal contacts and in addition reduces the flexibility of a loop of LdTyrRS. TyrSA is engaged in many interactions with active site residues occupying the tyrosine and adenine binding pockets. The LdTyrRS polypeptide chain consists of two pseudo-monomers, each consisting of two domains...
April 17, 2017: Biochimie
https://www.readbyqxmd.com/read/28426297/note-from-the-editor-in-chief-who-wants-to-exclude-older-lgbt-persons-from-public-health-surveillance
#13
Alfredo Morabia
It is sobering to publish Sell's call for every federal survey to include questions about sexual orientation and gender identity precisely when the Trump Administration excludes such questions from the proposed 2017 National Survey of Older Americans Act Participants (NSOAAP) conducted by the Administration for Community Living (ACL) in the Department of Health and Human Services. In particular, NSOAAP question DE1a, introduced in 2014, asked "Which of the following best represents how you think of yourself? Lesbian or Gay; Straight, that is, not lesbian or gay; Bisexual; Something else; Refused; Don't know...
April 20, 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28422683/progressive-dictionary-learning-with-hierarchical-predictive-structure-for-scalable-video-coding
#14
Wenrui Dai, Yangmei Shen, Hongkai Xiong, Xiaoqian Jiang, Junni Zou, David Taubman
Dictionary learning has emerged as a promising alternative to the conventional hybrid coding framework. However, the rigid structure of sequential training and prediction degrades its performance in scalable video coding. This paper proposes a progressive dictionary learning framework with hierarchical predictive structure for scalable video coding, especially in low bitrate region. For pyramidal layers, sparse representation based on spatio-temporal dictionary is adopted to improve the coding efficiency of enhancement layers (ELs) with a guarantee of reconstruction performance...
April 12, 2017: IEEE Transactions on Image Processing: a Publication of the IEEE Signal Processing Society
https://www.readbyqxmd.com/read/28422165/structural-basis-of-inhibition-of-lipid-linked-oligosaccharide-flippase-pglk-by-a-conformational-nanobody
#15
Camilo Perez, Martin Köhler, Daniel Janser, Els Pardon, Jan Steyaert, Renato Zenobi, Kaspar P Locher
PglK is an ABC transporter that flips a lipid-linked oligosaccharide (LLO) that serves as a donor in protein N-glycosylation. Previous structures revealed two inward-facing conformations, both with very large separations of the nucleotide binding domains (NBDs), and a closed, ADP-bound state that featured an occluded cavity. To investigate additional states, we developed conformation-sensitive, single-domain camelid nanobodies (Nb) and studied their effect on PglK activity. Biochemical, structural, and mass spectrometric analyses revealed that one inhibitory Nb binds as a single copy to homodimeric PglK...
April 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28422076/zeglobaltox-an-innovative-approach-to-address-organ-drug-toxicity-using-zebrafish
#16
Carles Cornet, Simone Calzolari, Rafael Miñana-Prieto, Sylvia Dyballa, Els van Doornmalen, Helma Rutjes, Thierry Savy, Davide D'Amico, Javier Terriente
Toxicity is one of the major attrition causes during the drug development process. In that line, cardio-, neuro-, and hepatotoxicities are among the main reasons behind the retirement of drugs in clinical phases and post market withdrawal. Zebrafish exploitation in high-throughput drug screening is becoming an important tool to assess the toxicity and efficacy of novel drugs. This animal model has, from early developmental stages, fully functional organs from a physiological point of view. Thus, drug-induced organ-toxicity can be detected in larval stages, allowing a high predictive power on possible human drug-induced liabilities...
April 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28420261/added-value-of-early-literacy-screening-in-preschool-children
#17
Sai Nandini Iyer, M Zachary Dawson, Mark I Sawyer, Neelab Abdullah, Leya Saju, Robert D Needlman
The Early Literacy Screener (ELS) is a brief screen for emergent literacy delays in 4- and 5-year-olds. Standard developmental screens may also flag these children. What is the value of adding the ELS? Parents of children aged 4 (n = 45) and 5 (n = 26) years completed the Ages and Stages Questionnaire-3 (ASQ-3), the Survey of Well-Being in Young Children (SWYC), and the ELS. Rates of positive agreement (PA), negative agreement (NA), and overall agreement (Cohen's κ) across the various screening tools were calculated...
April 1, 2017: Clinical Pediatrics
https://www.readbyqxmd.com/read/28419094/an-open-source-pharma-roadmap
#18
Manica Balasegaram, Peter Kolb, John McKew, Jaykumar Menon, Piero Olliaro, Tomasz Sablinski, Zakir Thomas, Matthew H Todd, Els Torreele, John Wilbanks
In an Essay, Matthew Todd and colleagues discuss an open source approach to drug development.
April 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28415961/changing-practices-and-shifting-meanings-of-female-genital-cutting-among-the-maasai-of-arusha-and-manyara-regions-of-tanzania
#19
Hannelore Van Bavel, Gily Coene, Els Leye
Using mixed methods that combined participant observation and semi-structured in-depth interviews, this study looked at changing practices and shifting meanings of female genital cutting among the Maasai people in Tanzania. The findings suggest that an increasing social pressure to abandon female genital cutting has inspired the hiding of the practice, causing the actual cutting to become detached from its traditional ceremonial connotations. This detaching of cutting from ceremony has created a shift in meanings: the ceremony still carries the meaning of passage into adulthood, while the cutting seems to function as a way of inscribing Maasai identity into the body...
April 18, 2017: Culture, Health & Sexuality
https://www.readbyqxmd.com/read/28414132/epigenetic-modification-of-glucocorticoid-receptor-promoter-i7-in-maternally-separated-and-restraint-stressed-rats
#20
Sung Woo Park, Jung Goo Lee, Mi Kyoung Seo, Nguyen Ngoc Ly, Chan Hong Lee, Hye Yeon Cho, Le Thi Hein, Ah Jeong Choi, Gyung-Mee Kim, Young Hoon Kim
Glucocorticoid receptor (GR) promoter I7 is susceptible to epigenetic changes induced by environmental influences. Early life stress (ELS) has a persistent impact on GR expression, as well as behavior, in adult rodents via epigenetic changes of GR promoter I7. Moreover, various stressors can induce histone modifications in this region during adulthood. Thus, the present study aimed to investigate whether maternally separated (MS) rats exposed to chronic restraint stress (RS) would exhibit histone modifications of GR promoter I7 in the hippocampus...
April 13, 2017: Neuroscience Letters
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