keyword
https://read.qxmd.com/read/38512482/fam83d-acts-as-an-oncogene-by-regulating-cell-cycle-progression-via-multiple-pathways-in-synovial-sarcoma-a-potential-novel-downstream-target-oncogene-of-anlotinib
#1
JOURNAL ARTICLE
Zi-Mei Liu, Ying Yuan, Lei Jin
OBJECTIVE: Synovial Sarcoma (SS), a highly malignant mesenchymal neoplasm, typically carries a grim prognosis for patients presenting with high-grade or metastatic disease. Although Anlotinib, a new agent for treating soft tissue sarcomas, holds promise, its underlying mechanism remains incompletely understood. This investigation aims to delineate Anlotinib's anticancer effectiveness and potential mechanistic underpinnings in patients suffering from advanced, refractory SS. MATERIALS AND METHODS: Employing microarray assay, we examined the potential downstream targets of Anlotinib in SS therapy...
March 21, 2024: Discover. Oncology
https://read.qxmd.com/read/38454442/the-fbxw7-binding-sites-on-fam83d-are-potential-targets-for-cancer-therapy
#2
JOURNAL ARTICLE
Xiaoyu Jiang, Yuli Wang, Lulu Guo, Yige Wang, Tianshu Miao, Lijuan Ma, Qin Wei, Xiaoyan Lin, Jian-Hua Mao, Pengju Zhang
Increasing evidence shows the oncogenic function of FAM83D in human cancer, but how FAM83D exerts its oncogenic function remains largely unclear. Here, we investigated the importance of FAM83D/FBXW7 interaction in breast cancer (BC). We systematically mapped the FBXW7-binding sites on FAM83D through a comprehensive mutational analysis together with co-immunoprecipitation assay. Mutations at the FBXW7-binding sites on FAM83D led to that FAM83D lost its capability to promote the ubiquitination and proteasomal degradation of FBXW7; cell proliferation, migration, and invasion in vitro; and tumor growth and metastasis in vivo, indicating that the FBXW7-binding sites on FAM83D are essential for its oncogenic functions...
March 7, 2024: Breast Cancer Research: BCR
https://read.qxmd.com/read/38043628/mettl3-regulates-fam83d-m-6-a-modification-to-accelerate-tumorigenesis-of-triple-negative-breast-cancer-via-the-wnt-%C3%AE-catenin-pathway
#3
JOURNAL ARTICLE
Xiaodong Yu, Yaxun Li, Fanshuang Kong, Qun Xu
N6-methyladenosine (m6 A) modification, the most abundant methylation modification on eukaryotic mRNAs, was implicated in the tumourigenesis. This study aimed to explore the role of methyltransferase like 3 (METTL3) in triple-negative breast cancer progression and its underlying mechanisms. FAM83D was markedly elevated in triple-negative breast cancer tissues and cells, and high expression of FAM83D was related to the poor prognosis of triple-negative breast cancer patients. FAM83D knockdown significantly retarded cell proliferation, invasion, stemness, and accelerated cell apoptosis in triple-negative breast cancer cells...
December 1, 2023: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://read.qxmd.com/read/37958803/-dlgap5-regulates-the-proliferation-migration-invasion-and-cell-cycle-of-breast-cancer-cells-via-the-jak2-stat3-signaling-axis
#4
JOURNAL ARTICLE
Yujie Li, Jie Wei, Yao Sun, Wenqian Zhou, Xiaoya Ma, Jinping Guo, Huan Zhang, Tianbo Jin
The aim of this study was to discover new biomarkers to detect breast cancer (BC), which is an aggressive cancer with a high mortality rate. In this study, bioinformatic analyses (differential analysis, weighted gene co-expression network analysis, and machine learning) were performed to identify potential candidate genes for BC to study their molecular mechanisms. Furthermore, Quantitative Real-time PCR and immunohistochemistry assays were used to examine the protein and mRNA expression levels of a particular candidate gene ( DLGAP5 )...
October 31, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37828118/advanced-stage-high-grade-primary-tumor-ovarian-cancer-a-multi-omics-dissection-and-biomarker-prediction-process
#5
JOURNAL ARTICLE
Yousof Saeedi Honar, Saleh Javaher, Marziye Soleimani, Amir Zarebkohan, Behrouz Farhadihosseinabadi, Masoud Tohidfar, Meghdad Abdollahpour-Alitappeh
Ovarian cancer (OC) incidence and mortality rates continue to escalate globally. Early detection of OC is challenging due to extensive metastases and the ambiguity of biomarkers in advanced High-Grade Primary Tumors (HGPTs). In the present study, we conducted an in-depth in silico analysis in OC cell lines using the Gene Expression Omnibus (GEO) microarray dataset with 53 HGPT and 10 normal samples. Differentially-Expressed Genes (DEGs) were also identified by GEO2r. A variety of analyses, including gene set enrichment analysis (GSEA), ChIP enrichment analysis (ChEA), eXpression2Kinases (X2K) and Human Protein Atlas (HPA), elucidated signaling pathways, transcription factors (TFs), kinases, and proteome, respectively...
October 12, 2023: Scientific Reports
https://read.qxmd.com/read/37772256/establishment-of-a-7-gene-expression-panel-to-improve-the-prognosis-classification-of-gastric-cancer-patients
#6
JOURNAL ARTICLE
Mariana Belén Velásquez Sotomayor, Anthony Vladimir Campos Segura, Ricardo José Asurza Montalva, Obert Marín-Sánchez, Alexis Germán Murillo Carrasco, César Alexander Ortiz Rojas
Gastric cancer (GC) ranks fifth in incidence and fourth in mortality worldwide. The high death rate in patients with GC requires new biomarkers for improving survival estimation. In this study, we performed a transcriptome-based analysis of five publicly available cohorts to identify genes consistently associated with prognosis in GC. Based on the ROC curve, patients were categorized into high and low-expression groups for each gene using the best cutoff point. Genes associated with survival (AUC > 0.5; univariate and multivariate Cox regressions, p < 0...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37414767/mobile-pipeline-enables-identification-of-context-specific-networks-and-regulatory-mechanisms
#7
JOURNAL ARTICLE
Cemal Erdem, Sean M Gross, Laura M Heiser, Marc R Birtwistle
Robust identification of context-specific network features that control cellular phenotypes remains a challenge. We here introduce MOBILE (Multi-Omics Binary Integration via Lasso Ensembles) to nominate molecular features associated with cellular phenotypes and pathways. First, we use MOBILE to nominate mechanisms of interferon-γ (IFNγ) regulated PD-L1 expression. Our analyses suggest that IFNγ-controlled PD-L1 expression involves BST2, CLIC2, FAM83D, ACSL5, and HIST2H2AA3 genes, which were supported by prior literature...
July 6, 2023: Nature Communications
https://read.qxmd.com/read/37309005/comprehensive-dna-methylation-profiling-of-covid-19-and-hepatocellular-carcinoma-to-identify-common-pathogenesis-and-potential-therapeutic-targets
#8
JOURNAL ARTICLE
Huiyan Luo, Jixin Chen, Qiyin Jiang, Yifan Yu, Miaolun Yang, Yuehua Luo, Xiongwen Wang
BACKGROUND & AIMS: The effects of SARS-CoV-2 infection can be more complex and severe in patients with hepatocellular carcinoma (HCC) as compared to other cancers. This is due to several factors, including pre-existing conditions such as viral hepatitis and cirrhosis, which are commonly associated with HCC. METHODS: We conducted an analysis of epigenomics in SARS-CoV-2 infection and HCC patients, and identified common pathogenic mechanisms using weighted gene co-expression network analysis (WGCNA) and other analyses...
June 12, 2023: Clinical Epigenetics
https://read.qxmd.com/read/37205181/identification-of-novel-molecular-subtypes-and-a-signature-to-predict-prognosis-and-therapeutic-response-based-on-cuproptosis-related-genes-in-prostate-cancer
#9
JOURNAL ARTICLE
Jili Zhang, Shaoqin Jiang, Di Gu, Wenhui Zhang, Xianqi Shen, Min Qu, Chenghua Yang, Yan Wang, Xu Gao
BACKGROUND: Prostate cancer (PCa) is the most common malignant tumor of the male urinary system. Cuproptosis, as a novel regulated cell death, remains unclear in PCa. This study aimed to investigate the role of cuproptosis-related genes (CRGs) in molecular stratification, prognostic prediction, and clinical decision-making in PCa. METHODS: Cuproptosis-related molecular subtypes were identified by consensus clustering analysis. A prognostic signature was constructed with LASSO cox regression analyses with 10-fold cross-validation...
2023: Frontiers in Oncology
https://read.qxmd.com/read/36720221/an-affinity-directed-phosphatase-adphosphatase-system-for-targeted-protein-dephosphorylation
#10
JOURNAL ARTICLE
Luke M Simpson, Luke J Fulcher, Gajanan Sathe, Abigail Brewer, Jin-Feng Zhao, Daniel R Squair, Jennifer Crooks, Melanie Wightman, Nicola T Wood, Robert Gourlay, Joby Varghese, Renata F Soares, Gopal P Sapkota
Reversible protein phosphorylation, catalyzed by protein kinases and phosphatases, is a fundamental process that controls protein function and intracellular signaling. Failure of phospho-control accounts for many human diseases. While a kinase phosphorylates multiple substrates, a substrate is often phosphorylated by multiple kinases. This renders phospho-control at the substrate level challenging, as it requires inhibition of multiple kinases, which would thus affect other kinase substrates. Here, we describe the development and application of the affinity-directed phosphatase (AdPhosphatase) system for targeted dephosphorylation of specific phospho-substrates...
January 25, 2023: Cell Chemical Biology
https://read.qxmd.com/read/36710419/systematic-analysis-of-the-oncogenic-role-of-fam83d-across-cancers-based-on-data-mining
#11
JOURNAL ARTICLE
Yan Geng, Jing Liu, Zichuan Wang, Tianzi Liu, Xintong Peng, Yan Huang
Family with sequence similarity of 83D (FAM83D) is overexpressed in various cancers. However, no pan-cancer analysis is presently available. In the present study, we used a bioinformatics analysis to explore the diagnostic and prognostic value of FAM83D expression levels in human cancers. The GEPIA 2, TIMER 2.0, ENCORI, and DriverDBV3 databases were used to evaluate FAM83D expression levels. The potential prognostic value of FAM83D expression was analyzed using the GEPIA 2, UALCAN, and TISIB databases. The driver gene and promoter methylation levels regarding FAM83D were evaluated using the TIMER 2...
January 29, 2023: Cell Cycle
https://read.qxmd.com/read/36568373/pan-cancer-and-single-cell-analysis-reveals-fam83d-expression-as-a-cancer-prognostic-biomarker
#12
JOURNAL ARTICLE
Haiyang Yu, Qinhao Chen, Ziming Wang, Xiaojun Qian, Yueyin Pan
Background: The family with sequence similarity 83 member D ( FAM83D ) protein is known to play a significant role in many human diseases. However, its role in cancer remains ambiguous. This study aimed to investigate the function of FAM83D in a pan - cancer analysis, with a special focus on breast cancer. Methods: Samples were collected from The Cancer Genome Atlas (TCGA) and used for bioinformatic analysis. Datasets from the Gene Expression Omnibus (GEO) and Genotype-Tissue Expression (GTEx) databases were also analyzed for verification...
2022: Frontiers in Genetics
https://read.qxmd.com/read/36568230/integrating-single-cell-rna-sequencing-and-prognostic-model-revealed-the-carcinogenicity-and-clinical-significance-of-fam83d-in-ovarian-cancer
#13
JOURNAL ARTICLE
Jie Li, Zhefeng Li, Yan Gao, Hongyu Zhao, Jiahao Guo, Zhibin Liu, Chenghong Yin, Xiaoting Zhao, Wentao Yue
BACKGROUND: Ovarian cancer (OC) is a fatal gynecological tumor with high mortality and poor prognosis. Yet, its molecular mechanism is still not fully explored, and early prognostic markers are still missing. In this study, we assessed carcinogenicity and clinical significance of family with sequence similarity 83 member D (FAM83D) in ovarian cancer by integrating single-cell RNA sequencing (scRNA-seq) and a prognostic model. METHODS: A 10x scRNA-seq analysis was performed on cells from normal ovary and high-grade serous ovarian cancer (HGSOC) tissue...
2022: Frontiers in Oncology
https://read.qxmd.com/read/36388033/-fam83d-promotes-the-proliferation-and-migration-of-hepatocellular-carcinoma-cells-by-inhibiting-the-fbxw7-mcl1-pathway
#14
JOURNAL ARTICLE
Jiao Nie, Lin Lu, Chao Du, Xiaozhong Gao
Background: Hepatocellular carcinoma (HCC) is one of the most malignant tumors and has a poor 5-year survival rate. Family with sequence similarity 83, member D ( FAM83D ) is characterized as an oncogenic gene related to cell proliferation in many tumors, but the role and underlying mechanism of FAM83D in the development of HCC are still unclear. Methods: FAM83D expression profiles and clinicopathological data were obtained from The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC)...
October 2022: Translational Cancer Research
https://read.qxmd.com/read/35800363/multicellular-biomarkers-of-drug-resistance-as-promising-targets-for-glioma-precision-medicine-and-predictors-of-patient-survival
#15
JOURNAL ARTICLE
Yuting Lu, Yongzhao Shao
Aim : This study aimed to translate a known drug-resistance mechanism of long-term CSF1R inhibition into multicellular biomarkers that can serve as potential therapeutic targets as well as predictive markers for the survival of glioma patients. Methods : Using existing data from a published mouse study of drug resistance in immunotherapy for glioma, we identified multicellular differentially expressed genes (DEGs) between drug-sensitive and drug-resistant mice and translated the DEGs in mouse genome to human homolog...
2022: Cancer Drug Resistance
https://read.qxmd.com/read/35650627/comprehensive-analysis-of-the-expression-prognostic-significance-and-function-of-fam83-family-members-in-breast-cancer
#16
JOURNAL ARTICLE
Yi Jin, Jiahui Yu, Yi Jiang, Jiawen Bu, Tong Zhu, Xi Gu, Xudong Zhu
BACKGROUND: The FAM83 family plays a key role in tumorigenesis and cancer progression. However, the role of the FAM83 family in the development of breast tumors is unclear to date. This report explores the expression, prognostic significance, and function of the FAM83 family members in breast cancer using public databases. METHODS: UALCAN database was used to explore the expression of FAM83 family members in breast cancer. Furthermore, we validated the expression of FAM83 family members in twenty pairs of breast cancer and normal tissues by RT-PCR...
June 1, 2022: World Journal of Surgical Oncology
https://read.qxmd.com/read/35646670/over-expression-of-long-non-coding-rna-ac099850-3-correlates-with-tumor-progression-and-poor-prognosis-in-lung-adenocarcinoma
#17
JOURNAL ARTICLE
Xi Chen, Jishu Guo, Fan Zhou, Wenjun Ren, Jun Pu, Luciano Mutti, Xiaoqun Niu, Xiulin Jiang
Lung adenocarcinoma (LUAD) is the most common histological lung cancer, and it is the leading cause of cancer-related deaths worldwide. Long noncoding RNAs (lncRNAs) have been implicated in the initiation and progression of various cancers. LncRNA-AC099850.3 is a novel lncRNA that is abnormally expressed in diverse cancer types including LUAD. However, the clinical significance, prognostic value, diagnostic value, immune role, and potential biological function of AC099850.3 LUAD remain elusive. In this study, we found that AC099850...
2022: Frontiers in Oncology
https://read.qxmd.com/read/35617811/suppression-of-fam83d-inhibits-glioma-proliferation-invasion-and-migration-by-regulating-the-akt-mtor-signaling-pathway
#18
JOURNAL ARTICLE
Xia Li, Cui Sun, Jing Chen, Ji-Fen Ma, Yi-Heng Pan
OBJECTIVE: To explore the mechanism by which the family with sequence similarity 83, member D (FAM83D)-mediated AKT/mTOR signaling pathway activation affects the proliferation and metastasis of glioma cells. METHODS: FAM83D protein expression in glioma cells and tissues was detected by western blotting. Glioma U87 and U251 cells were selected and divided into the Mock, siNC, siFAM83D, FAM83D, MK2206 and FAM83D + MK2206 groups. Cell proliferation was assessed by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) and clone formation assays, while invasion and migration were evaluated by Transwell assays and wound healing tests...
May 23, 2022: Translational Oncology
https://read.qxmd.com/read/35489022/mirna-142-3p-functions-as-a-potential-tumor-suppressor-directly-targeting-fam83d-in-the-development-of-ovarian-cancer
#19
JOURNAL ARTICLE
Guangyu Gao, Xiaofei Guo, Wenyong Gu, Yufeng Lu, Zhigang Chen
BACKGROUND: FAM83D (family with sequence similarity 83, member D) is of particular interest in tumorigenesis and tumor progression. Ovarian cancer is the leading cause of cancer-related death in women all over the world. This study aims to research the association between FAM83D and ovarian cancer (OC). METHODS: The gene expression data of OC and normal samples (GSE81873 and GSE27651) was downloaded from Gene Expression Omnibus (GEO) dataset. The bioinformatics analysis was performed to distinguish two differentially expressed genes (DEGs), prognostic candidate genes and functional enrichment pathways...
April 22, 2022: Aging
https://read.qxmd.com/read/34869310/comprehensive-analysis-and-identification-of-prognostic-biomarkers-and-therapeutic-targets-among-fam83-family-members-for-gastric-cancer
#20
JOURNAL ARTICLE
Tianhao Zhang, Shurong Lai, Yuzhi Cai, Zhixin Huang, Ying Li, Sile Chen, Zhimei Zhang, Zhijun Ye, Xiaoling Lai, Ertao Zhai, Shirong Cai, Jianhui Chen
Background: Gastric cancer (GC) is one of the most common and poor prognosis malignancy in the world. The Family with sequence similarity 83 (FAM83) comprises of eight members of A-H. Accumulating evidence confirmed important roles for FAM83 family in tumorigenesis and progression. However, the prognostic values of FAM83 family in GC still have not been clarified. Methods: ONCOMINE, UALCAN, GEPIA, THE HUMAN PROTEIN ATLAS, Kaplan-Meier Plotter, cBioPortal, DAVID, STRING and TIMER databases and R software were adopted in this study...
2021: Frontiers in Cell and Developmental Biology
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