keyword
https://read.qxmd.com/read/38468464/gins1-promotes-zeb1-mediated-epithelial-mesenchymal-transition-and-tumor-metastasis-via-%C3%AE-catenin-signaling-in-hepatocellular-carcinoma
#1
JOURNAL ARTICLE
Junjie Liang, Nan Yao, Bo Deng, Jinying Li, Yuchuan Jiang, Tongzheng Liu, Youzhu Hu, Mingrong Cao, Jian Hong
GINS1 regulates DNA replication in the initiation and elongation phases and plays an important role in the progression of various malignant tumors. However, the role of GINS1 in hepatocellular carcinoma (HCC) remains largely unclear. In this study, we investigated the role and underlying mechanisms of GINS1 in contributing to HCC metastasis. We found that GINS1 was significantly upregulated in HCC tissues and cell lines, especially in HCC tissues with vascular invasion and HCC cell lines with highly metastatic properties...
March 11, 2024: Journal of Cellular Physiology
https://read.qxmd.com/read/38301047/complementary-biomarkers-of-computed-tomography-for-diagnostic-grading-of-gastric-cancer-dscc1-and-gins1
#2
JOURNAL ARTICLE
Yufeng Zhu, Shiyang Hou, Chunbo Kang
OBJECTIVE: Computed tomography (CT) is an important tool for grading gastric cancer. Gastric cancer typically originates from epithelial cells of gastric mucosa. However, complementary markers for gastric cancer, relationship between DSCC1, GINS1 and gastric cancer remain unclear. METHODS: Gastric cancer data were obtained from gene expression omnibus (GEO). Differentially expressed genes (DEGs) were identified, weighted gene co-expression network analysis (WGCNA) was conducted...
January 31, 2024: Aging
https://read.qxmd.com/read/37904396/roles-of-dscc1-and-gins1-in-gastric-cancer
#3
JOURNAL ARTICLE
Shiyang Hou, Jie Zhang, Xiaoqian Chi, Xiaowei Li, Qijun Zhang, Chunbo Kang, Haifeng Shan
Gastric carcinoma is a common malignant tumor originating from gastric mucosal epithelium. However, role of DS-cell cycle-dependent protein 1 (DSCC1) and GINS1 in gastric carcinoma remains unclear. The gastric carcinoma datasets GSE79973 and GSE118916 were downloaded from gene expression omnibus. Multiple datasets were merged and batched. Differentially expressed genes (DEGs) were screened and weighted gene co-expression network analysis was performed. Functional enrichment analysis, gene set enrichment analysis and immune infiltration analysis were performed...
October 27, 2023: Medicine (Baltimore)
https://read.qxmd.com/read/37824372/transcription-factor-e2f1-enhances-hepatocellular-carcinoma-cell-proliferation-and-stemness-by-activating-gins1
#4
JOURNAL ARTICLE
Xuefeng Ren, Lianqiang Shen, Shan Gao
Present studies report that high expression of GINS complex subunit 1 (GINS1) is notably pertinent to poor survival for hepatocellular carcinoma (HCC), but it remains unclear how GINS1 affects the progression of HCC. This study aims at investigating the mechanism by which GINS1 affects HCC cell proliferation and stemness. We performed bioinformatics analysis for determining GINS1 expression in HCC tissues, as well as the HCC patients' survival rate with different expression levels of GINS1. E2F transcription factor 1 (E2F1) was predicted as the upstream transcription factor of GINS1, and the binding relation between the two was verified by chromatin immunoprecipitation and dual-luciferase reporter assays...
2024: Journal of Environmental Pathology, Toxicology and Oncology
https://read.qxmd.com/read/37576391/foxp1-gins1-axis-promotes-dlbcl-proliferation-and-directs-doxorubicin-resistance
#5
JOURNAL ARTICLE
Zhenfa Chen, Ting Wang, Cui Li, Wei Zhang, Wenbin Huang, Jun Xue, Jundong Wang, Shufeng Li
GINS1 is overexpressed in several types of cancers including leukemia and linked to poor outcomes. However, GINS1 remains poorly investigated in DLBCL (diffuse large B-cell lymphoma). This project aimed to explore the expression, functions and regulation of GINS1 in DLBCL. In this study, through analysis of clinical specimens from DLBCL patients, we uncovered that GINS1 was upregulated in DLBCL. By EMSA, ChIP and luciferase reporter assays, it was found that FOXP1 transcriptionally activated GINS1 expression by directly binding to the promoter region of the GINS1 gene...
2023: Journal of Cancer
https://read.qxmd.com/read/37456470/in-silico-characterization-of-rnaseh2a-pathogenic-variants-and-identification-of-novel-splice-site-donor-variant-c-549-1g-t-in-indian-population
#6
JOURNAL ARTICLE
Vykuntaraju K Nanjundagowda, Swabhiman Paikaraya, Varunvenkat M Srinivasan, Anshika Srivastava
Background Aicardi-Goutieres syndrome (AGS) is a genetic disorder that has variable manifestations including neurological, immunological, and sometimes other system involvement in various combinations. Considering the high genetic and clinical diversity of AGS and the importance of RNASEH2 complex in the biological system, it is important to take a systematic approach to delineate the genetic diagnosis and impact of missense mutations. Methods Clinical targeted gene sequencing followed by Sanger validation was performed in an individual with the clinical features of AGS...
June 2023: Curēus
https://read.qxmd.com/read/37221950/pax5-and-circ1857-affected-dlbcl-progression-and-b-cell-proliferation-through-regulating-gins1
#7
JOURNAL ARTICLE
Ting Wang, Zhenfa Chen, Cui Li, Wei Zhang, Wenbin Huang, Jun Xue, Jundong Wang, Shufeng Li
PAX5, a member of the paired box gene family of transcription factors, is a B-cell-specific activator protein that plays important roles during B lymphopoiesis. Two putative PAX5 binding sites in the human GINS1 promoter region were identified. EMSA, ChIP and luciferase assay showed that PAX5 functions as a positive transcription factor for GINS1 expression. Furthermore, coordinated expression of PAX5 and GINS1 was observed in mice B cells under physiological conditions and LPS stimulation situations. A similar pattern was also observed in human DLBCL cell lines under differentiation-inducing conditions...
May 23, 2023: Cancer Science
https://read.qxmd.com/read/37180662/identification-of-gins1-as-a-potential-prognostic-biomarker-for-sarcoma-using-bioinformatic-analysis
#8
JOURNAL ARTICLE
Huanhuan Zhao, Xiaoxia He, Zhanbei Ma
BACKGROUND: The GINS complex is related to cancer development, invasion, and poor prognosis in multiple tumors. In the study, we attempted to investigate the prognostic value of GINS1 in sarcoma patients. METHODS: We analyzed GINS1 expression using Tumor IMmune Estimation Resource (TIMER) 2.0, Gene Expression Omnibus (GEO; GSE21122, GSE39262, and GSE21050), and The Cancer Genome Atlas (TCGA) databases. The prognostic value of GINS1 was explored using the survival and survminer packages of R...
April 28, 2023: Translational Cancer Research
https://read.qxmd.com/read/36910651/developing-mrna-signatures-as-a-novel-prognostic-biomarker-predicting-high-risk-multiple-myeloma
#9
JOURNAL ARTICLE
Jing Wang, Lili Guo, Chenglan Lv, Min Zhou, Yuan Wan
BACKGROUND: Multiple myeloma (MM) remains an essentially incurable disease. This study aimed to establish a predictive model for estimating prognosis in newly diagnosed MM based on gene expression profiles. METHODS: RNA-seq data were downloaded from the Multiple Myeloma Research Foundation (MMRF) CoMMpass Study and the Genotype-Tissue Expression (GTEx) databases. Weighted gene coexpression network analysis (WGCNA) and protein-protein interaction network analysis were performed to identify hub genes...
2023: Frontiers in Oncology
https://read.qxmd.com/read/36660705/bioinformatics-analysis-of-the-prognostic-biomarkers-and-predictive-accuracy-of-differentially-expressed-genes-in-high-risk-multiple-myeloma-based-on-gene-expression-omnibus-database-mining
#10
JOURNAL ARTICLE
Chenxiao Du, Dongmei Guo, Yuhui Zhang, Chao Gao, Jie Bai
BACKGROUND: Multiple myeloma (MM) is still an intractable disease for modern clinical system, and more researches are necessary for development of more effective therapeutic strategies. This study attempted to screen and validates the biomarkers in the progression of MM via excavating Gene Expression Omnibus (GEO) database. Identification of a biomarker may help not only facilitate early diagnosis and management but also identify individuals at risk for poor prognosis and development of MM...
December 2022: Annals of Translational Medicine
https://read.qxmd.com/read/36516748/increased-replication-origin-firing-links-replication-stress-to-whole-chromosomal-instability-in-human-cancer
#11
JOURNAL ARTICLE
Nicolas Böhly, Ann-Kathrin Schmidt, Xiaoxiao Zhang, Benjamin O Slusarenko, Magdalena Hennecke, Maik Kschischo, Holger Bastians
Chromosomal instability (CIN) is a hallmark of cancer and comprises structural CIN (S-CIN) and numerical or whole chromosomal CIN (W-CIN). Recent work indicated that replication stress (RS), known to contribute to S-CIN, also affects mitotic chromosome segregation, possibly explaining the common co-existence of S-CIN and W-CIN in human cancer. Here, we show that RS-induced increased origin firing is sufficient to trigger W-CIN in human cancer cells. We discovered that overexpression of origin firing genes, including GINS1 and CDC45, correlates with W-CIN in human cancer specimens and causes W-CIN in otherwise chromosomally stable human cells...
December 13, 2022: Cell Reports
https://read.qxmd.com/read/36469009/a-novel-tumor-promoting-role-for-nuclear-factor-ix-in-glioblastoma-is-mediated-through-transcriptional-activation-of-gins1
#12
JOURNAL ARTICLE
Ruixiang Ge, Chenci Wang, Jiangang Liu, Haibo Jiang, Xiaochun Jiang, Zhuohao Liu
Our previous study illustrated that nuclear factor IX (NFIX) promotes glioblastoma (GBM) progression by inducing migration and proliferation of GBM cells. However, the underlying mechanism of how NFIX regulates GBM cell proliferation remains obscure. In this study, we uncovered that Go-Ichi-Ni-San 1 (GINS1) is up-regulated and positively correlated with NFIX in human GBM specimen. NFIX silencing down-regulates the expression of GINS1, which is pivotal for cell-cycle progression and proliferation of GBM cells...
December 5, 2022: Molecular Cancer Research: MCR
https://read.qxmd.com/read/36465268/espl1-is-elevated-in-hepatocellular-carcinoma-and-predicts-prognosis
#13
JOURNAL ARTICLE
Rui Song, Juntao Huang, Chenglei Yang, Yuankuan Li, Guohua Zhan, Bangde Xiang
PURPOSE: The extra spindle pole bodies-like 1 ( ESPL1 ) gene is associated with malignant biological behaviors in several tumors. Nevertheless, the correlation between hepatocellular carcinoma (HCC) and ESPL1 has not been determined. The present study analyzed the molecular function and prognostic value of ESPL1 in HCC. PATIENTS AND METHODS: Samples from 121 HCCs and 119 adjacent normal tissue specimens were subjected to next-generation sequencing. Clinicopathological and genetic data of HCC patients in The Cancer Genome Atlas (TCGA) were also collected...
2022: International Journal of General Medicine
https://read.qxmd.com/read/36451247/identification-of-gins1-as-a-therapeutic-target-in-the-cancer-patients-infected-with-covid-19-a-bioinformatics-and-system-biology-approach
#14
JOURNAL ARTICLE
Changpeng Hu, Yue Dai, Huyue Zhou, Jing Zhang, Dandan Xie, Rufu Xu, Mengmeng Yang, Rong Zhang
BACKGROUND: Coronavirus disease 2019 (COVID-19) caused a series of biological changes in cancer patients which have rendered the original treatment ineffective and increased the difficulty of clinical treatment. However, the clinical treatment for cancer patients infected with COVID-19 is currently unavailable. Since bioinformatics is an effective method to understand undiscovered biological functions, pharmacological targets, and therapeutic mechanisms. The aim of this study was to investigate the influence of COVID-19 infection in cancer patients and to search the potential treatments...
December 1, 2022: Hereditas
https://read.qxmd.com/read/36345721/gene-interaction-perturbation-network-deciphers-a-high-resolution-taxonomy-in-colorectal-cancer
#15
JOURNAL ARTICLE
Zaoqu Liu, Siyuan Weng, Qin Dang, Hui Xu, Yuqing Ren, Chunguang Guo, Zhe Xing, Zhenqiang Sun, Xinwei Han
Molecular subtypes of colorectal cancer (CRC) are currently identified via the snapshot transcriptional profiles, largely ignoring the dynamic changes of gene expressions. Conversely, biological networks remain relatively stable irrespective of time and condition. Here, we introduce an individual-specific gene interaction perturbation network-based (GIN) approach and identify six GIN subtypes (GINS1-6) with distinguishing features: (i) GINS1 (proliferative, 24%~34%), elevated proliferative activity, high tumor purity, immune-desert, PIK3CA mutations, and immunotherapeutic resistance; (ii) GINS2 (stromal-rich, 14%~22%), abundant fibroblasts, immune-suppressed, stem-cell-like, SMAD4 mutations, unfavorable prognosis, high potential of recurrence and metastasis, immunotherapeutic resistance, and sensitive to fluorouracil-based chemotherapy; (iii) GINS3 ( KRAS -inactivated, 13%~20%), high tumor purity, immune-desert, activation of EGFR and ephrin receptors, chromosomal instability (CIN), fewer KRAS mutations, SMOC1 methylation, immunotherapeutic resistance, and sensitive to cetuximab and bevacizumab; (iv) GINS4 (mixed, 10%~19%), moderate level of stromal and immune activities, transit-amplifying-like, and TMEM106A methylation; (v) GINS5 (immune-activated, 12%~24%), stronger immune activation, plentiful tumor mutation and neoantigen burden, microsatellite instability and high CpG island methylator phenotype, BRAF mutations, favorable prognosis, and sensitive to immunotherapy and PARP inhibitors; (vi) GINS6, (metabolic, 5%~8%), accumulated fatty acids, enterocyte-like, and BMP activity...
November 8, 2022: ELife
https://read.qxmd.com/read/36310704/go-ichi-ni-san-2-a-potential-biomarker-and-therapeutic-target-in-human-cancers
#16
REVIEW
Dan-Dan Shan, Qiu-Xian Zheng, Zhi Chen
Cancer incidence and mortality are increasing globally, leading to its rising status as a leading cause of death. The Go-Ichi-Ni-San (GINS) complex plays a crucial role in DNA replication and the cell cycle. The GINS complex consists of four subunits encoded by the GINS1, GINS2, GINS3, and GINS4 genes. Recent findings have shown that GINS2 expression is upregulated in many diseases, particularly tumors. For example, increased GINS2 expression has been found in cervical cancer, gastric adenocarcinoma, glioma, non-small cell lung cancer, and pancreatic cancer...
October 15, 2022: World Journal of Gastrointestinal Oncology
https://read.qxmd.com/read/36202651/multi-genomic-analysis-of-260-adrenocortical-cancer-patient-tumors-identifies-novel-network-birc5-hsa-mir-335-5p-pax8-as1-strongly-associated-with-poor-survival
#17
JOURNAL ARTICLE
Chitra Subramanian, Reid McCallister, Mark S Cohen
BACKGROUND: Adrenocortical carcinoma is a rare endocrine cancer with poor overall survival. Linking survival outcomes to a common target across multiple genomic datasets incorporating microRNA-long non-coding RNA dysregulation have not been well described. We hypothesized that a multi-database analysis of microRNA-long noncoding RNA-messenger RNA regulatory networks associated with survival will identify novel biomarkers. METHODS: Significantly dysregulated genes or microRNA in adrenocortical carcinoma compared to normal adrenal was identified from sequencing data for 260 human adrenocortical carcinomas using GEO2R...
October 3, 2022: Surgery
https://read.qxmd.com/read/36092720/comprehensive-analysis-of-gins-subunits-prognostic-value-and-cerna-network-in-sarcoma
#18
JOURNAL ARTICLE
Chuqiao Zhou, Zhuoyuan Chen, Bo Xiao, Cheng Xiang, Aoyu Li, Ziyue Zhao, Hui Li
Background: The GINS complex, composed of GINS1/2/3/4 subunits, is an essential structure of Cdc45-MCM-GINS (CMG) helicase and plays a vital role in establishing the DNA replication fork and chromosome replication. Meanwhile, GINS genes have been associated with the poor prognosis of various malignancies. However, the abnormal expression of GINS genes and their diagnostic and prognostic value in sarcomas (SARC) remain unclear. Methods: Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Kaplan-Meier Plotter, Cancer cell line encyclopedia (CCLE), The University of Alabama at Birmingham Cancer Data Analysis Portal (UALCAN), R studio, and Tumor Immune Estimation Resource (TIMER) were used to analyze the expression profiles, prognostic value, biological function, ceRNA, and immune infiltration associated with GINS genes in sarcomas...
2022: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/36065190/gins1-promotes-the-proliferation-and-migration-of-glioma-cells-through-usp15-mediated-deubiquitination-of-top2a
#19
JOURNAL ARTICLE
Hui Yang, Xiaocen Liu, Xiaolong Zhu, Mengying Zhang, Yingying Wang, Mingzhe Ma, Kun Lv
GINS1 is a GINS complex subunit that functions along with the MCM2-7 complex and Cdc45 in eukaryotic DNA replication. Despite the significance of the GINS complex in the switch between quiescence and proliferation of glioma cells inside and outside the perinecrotic niche, the biological functions and the underlying mechanism of GINS1 remain unclear. Unlike in normal cells and tissues, GINS1 expression level was significantly upregulated in glioma cells and tissues. High expression of GINS1 predicted an advanced clinical grade and a poor survival...
September 16, 2022: IScience
https://read.qxmd.com/read/35896011/combined-analysis-of-expression-prognosis-and-immune-infiltration-of-gins-family-genes-in-human-sarcoma
#20
JOURNAL ARTICLE
Kexin Zhang, Jian Zhou, Tong Wu, Qunyan Tian, Tang Liu, Wanchun Wang, Hua Zhong, Ziyuan Chen, Xungang Xiao, Gen Wu
OBJECTIVE: This study was undertaken to explore the expression and prognostic value of GINS family in human sarcoma, as well as the association between the expression levels of the GINS family and sarcoma immune infiltration. RESULTS: We discovered that the mRNA expression levels of GINS1, GINS2, GINS3, and GINS4 were all higher in the majority of tumor tissues than in normal samples, of course, including sarcoma. Through the CCLE, all the four members expression were observed in high levels in sarcoma cell lines...
July 27, 2022: Aging
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