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https://www.readbyqxmd.com/read/28346809/malat1-promotes-osteosarcoma-development-by-regulation-of-hmgb1-via-mir-142-3p-and-mir-129-5p
#1
Ke Liu, Jun Huang, Jiangdong Ni, Deye Song, Muliang Ding, Junjie Wang, Xianzhe Huang, Wenzhao Li
Recently, emerging evidence has demonstrated that metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNAs (lncRNAs), contributes to the initiation and development of tumors, including osteosarcoma (OS). Multiple studies have suggested an oncogenic role of MALAT1 and high-mobility group protein B1 (HMGB1) in OS tumorigenesis and metastasis, but the effects and mechanisms are not unanimous. Here, we showed that MALAT1 and HMGB1 were significantly increased in human OS cell lines and knockdown of MALAT1 reduced HMGB1 expression...
March 19, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28338654/tfeb-vegfa-6p21-1-co-amplified-renal-cell-carcinoma-a-distinct-entity-with-potential-implications-for-clinical-management
#2
Sounak Gupta, Sarah H Johnson, George Vasmatzis, Binu Porath, Jeannette G Rustin, Priya Rao, Brian A Costello, Bradley C Leibovich, R Houston Thompson, John C Cheville, William R Sukov
A subset of renal cell carcinomas shows TFEB overexpression secondary to MALAT1-TFEB gene fusion. As alternate mechanisms of TFEB overexpression are likely to have the same effect, we sought to determine the frequency of amplification of TFEB and the adjacent VEGFA gene at 6p21.1. As patients with metastatic renal cell carcinomas are managed with anti-VEGF therapies, we retrospectively assessed therapeutic response in patients with amplified tumors. Amplification status was analyzed for 875 renal cell carcinomas from our institution, a consultative case and 794 cases from The Cancer Genome Atlas...
March 24, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28336564/identification-of-a-novel-syk-c-myc-malat1-signaling-pathway-and-its-potential-therapeutic-value-in-ewing-sarcoma
#3
Haibo Sun, De-Chen Lin, Qi Cao, Brendan Pang, David D Gae, Victor Km Lee, Huey Jin Lim, Ngan Doan, Jonathan W Said, Sigal Gery, Marilynn Chow, Anand Mayakonda, Charles Forscher, Jeffrey W Tyner, H Phillip Koeffler
PURPOSE: Ewing Sarcoma (EWS) is a devastating soft tissue sarcoma affecting predominantly young individuals. Tyrosine kinases (TKs) and associated pathways are continuously activated in many malignancies including EWS; these enzymes provide candidate therapeutic targets. EXPERIMENTAL DESIGN: Two high-throughput screens (a siRNA library and a small-molecule inhibitor library) were performed in EWS cells to establish candidate targets. Spleen tyrosine kinase (SYK) phosphorylation was assessed in EWS patients and cell lines...
March 23, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28326190/malat1-regulates-myogenic-differentiation-and-muscle-regeneration-through-modulating-myod-transcriptional-activity
#4
Xiaona Chen, Liangqiang He, Yu Zhao, Yuying Li, Suyang Zhang, Kun Sun, Karl So, Fengyuan Chen, Liang Zhou, Leina Lu, Lijun Wang, Xihua Zhu, Xichen Bao, Miguel A Esteban, Shinichi Nakagawa, Kannanganattu V Prasanth, Zhenguo Wu, Hao Sun, Huating Wang
Malat1 is one of the most abundant long non-coding RNAs in various cell types; its exact cellular function is still a matter of intense investigation. In this study we characterized the function of Malat1 in skeletal muscle cells and muscle regeneration. Utilizing both in vitro and in vivo assays, we demonstrate that Malat1 has a role in regulating gene expression during myogenic differentiation of myoblast cells. Specifically, we found that knockdown of Malat1 accelerates the myogenic differentiation in cultured cells...
2017: Cell Discovery
https://www.readbyqxmd.com/read/28268166/long-non-coding-rna-malat1-promotes-gastric-cancer-tumorigenicity-and-metastasis-by-regulating-vasculogenic-mimicry-and-angiogenesis
#5
Yue Li, Zhenzhen Wu, Jia Yuan, Li Sun, Li Lin, Na Huang, Jianping Bin, Yulin Liao, Wangjun Liao
MALAT1 is an oncogenic long non-coding RNA that has been found to promote the proliferation of many malignant cell types and non-malignant human umbilical vein endothelial cells (HUVECs). However, the functions of MALAT1 in vasculogenic mimicry (VM) and angiogenesis and the potential mechanisms responsible have not yet been investigated in any malignancy. Here, in situ hybridization and CD31/periodic acid-Schiff double staining of 150 gastric cancer (GC) clinical specimens revealed that MALAT1 expression was tightly associated with densities of VM and endothelial vessels...
March 6, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28260796/association-between-well-characterized-lung-cancer-lncrna-polymorphisms-and-platinum-based-chemotherapy-toxicity-in-chinese-patients-with-lung-cancer
#6
Wei-Jing Gong, Jing-Bo Peng, Ji-Ye Yin, Xiang-Ping Li, Wei Zheng, Ling Xiao, Li-Ming Tan, Di Xiao, Yi-Xin Chen, Xi Li, Hong-Hao Zhou, Zhao-Qian Liu
Platinum-based chemotherapy is the standard first-line treatment for most lung cancer patients. However, the toxicity induced by platinum-based chemotherapy greatly impedes its clinical use. Previous studies showed that long non-coding RNAs (lncRNAs) with over 200 nucleotides in length affect drug response and toxicity. In the present study, we investigated the association of well-characterized lung cancer lncRNA polymorphisms with platinum-based chemotherapy toxicity in Chinese patients with lung cancer. A total of 467 lung cancer patients treated with platinum-based chemotherapy for at least two cycles were recruited...
March 6, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28260109/absence-of-malat1-does-not-prevent-den-induced-hepatocarcinoma-in-mice
#7
Stéphanie Miard, Marie-Josée Girard, Philippe Joubert, Sophie Carter, Amy Gonzales, Huiping Guo, Benjamin Morpurgo, Louise Boivin, Andrei Golovko, Frédéric Picard
Long non-coding RNAs (lncRNA) are key regulators of gene expression both at the transcriptional and post-transcriptional levels. The lncRNA metastasis associated lung adenocarcinoma transcript 1 (Malat1) is overexpressed in many types of cancer, including hepatocarcinoma, and induces cell proliferation in several cell lines in vitro. However, the direct causal effects of Malat1 on hepatocyte proliferation and liver carcinogenesis in vivo are not fully understood. To better determine the contribution of Malat1 to hepatocarcinoma oncogenesis, this study was aimed at testing the hypothesis that its absence confers resistance to the development of liver tumors...
February 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28260102/long-non-coding-rna-malat1-interacts-with-mir-124-and-modulates-tongue-cancer-growth-by-targeting-jag1
#8
Tong-Han Zhang, Li-Zhong Liang, Xiao-Ling Liu, Ji-Nan Wu, Kui Su, Jue-Yao Chen, Qiao-Yi Zheng, Hong-Zhang Huang, Gui-Qing Liao
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long non-coding RNA (lncRNA), was the earliest discovered to be correlated with cancer and contributes to the initiation and development of several types of tumors. Dysregulation of MALAT1 expression is frequently observed in many types of cancer such as gastric cancer, esophageal squamous cell carcinoma and glioma. To date, the role of MALAT1 and the underlying mechanisms in tongue cancer development remain unclear. In the present study, we studied the influence of MALAT1 on tongue cancer cell lines and clinical tongue cancer samples so as to detect its function and the underlying mechanism...
February 14, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28253859/a-genetic-variant-in-long-non-coding-rna-malat1-associated-with-survival-outcome-among-patients-with-advanced-lung-adenocarcinoma-a-survival-cohort-analysis
#9
Jian-Zhong Wang, Jing-Jun Xiang, Li-Ge Wu, Yan-Sen Bai, Zhuo-Wang Chen, Xiang-Qian Yin, Qing Wang, Wen-Hao Guo, Ying Peng, Huan Guo, Ping Xu
BACKGROUND: Recently studies have demonstrated that the long non-coding RNA (lncRNA) metastasis associated lung adenocarcinoma transcript 1 (MALAT1) may participate in the development and progression of lung cancer. In this study, we hypothesized that genetic variant of this lncRNA may affect the prognosis of lung cancer patients. METHODS: We conducted a follow-up study for 538 patients with non-small cell lung carcinoma (NSCLC), including 140 early-staged (stage I and II) and 398 advanced staged (stage III and IV) patients...
March 3, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28253259/scalable-design-of-paired-crispr-guide-rnas-for-genomic-deletion
#10
Carlos Pulido-Quetglas, Estel Aparicio-Prat, Carme Arnan, Taisia Polidori, Toni Hermoso, Emilio Palumbo, Julia Ponomarenko, Roderic Guigo, Rory Johnson
CRISPR-Cas9 technology can be used to engineer precise genomic deletions with pairs of single guide RNAs (sgRNAs). This approach has been widely adopted for diverse applications, from disease modelling of individual loci, to parallelized loss-of-function screens of thousands of regulatory elements. However, no solution has been presented for the unique bioinformatic design requirements of CRISPR deletion. We here present CRISPETa, a pipeline for flexible and scalable paired sgRNA design based on an empirical scoring model...
March 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28252165/effects-of-mirna-143-and-the-non-coding-rna-malat1-on-the-pathogenesis-and-metastasis-of-hela-cells
#11
L Zhang, H E X D Niyazi, H R Zhao, X P Cao, M N S Abudula, W J Ye, S A Zhang, R H M Yiming, Y Zhang, W P Su, R Chen, Y Ouyang, N Miao, Y X Bao
Cervical cancer is a common female malignancy of global dimensions. MicroRNAs (miRNAs) play crucial roles in the development, differentiation, proliferation, and apoptosis of tumors. The non-coding RNA MALAT1 participates in various physiological processes that are important for proper functioning of the body. Here, we analyzed the expression of miRNA-143 and MALAT1 in HeLa cells to evaluate their roles in the occurrence and metastasis of cervical cancer. HeLa cells were divided into five groups depending on the treatment conditions, namely, transfected with miRNA-143, MALAT1, miRNA-143 inhibitor and the MALAT1 inhibitor, and the untreated control...
February 23, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28187000/malat1-is-a-prognostic-factor-in-glioblastoma-multiforme-and-induces-chemoresistance-to-temozolomide-through-suppressing-mir-203-and-promoting-thymidylate-synthase-expression
#12
Wei Chen, Xin-Ke Xu, Jun-Liang Li, Kuan-Kei Kong, Hui Li, Cheng Chen, Jing He, Fangyu Wang, Ping Li, Xiao-Song Ge, Fang-Cheng Li
Glioblastoma multiforme (GBM) is the most malignant brain tumor with limited therapeutic options. Temozolomide (TMZ) is a novel cytotoxic agent used as first-line chemotherapy for GBM, however, some individual cells can't be isolated for surgical resection and show treatment-resistance, thus inducing poor prognosis. By using the HiSeq sequencing and bioinformatics methods, we identified lncRNAs showing different expression levels in TMZ-resistant and non-resistant patients. RT-qPCR was then performed in tissues and serum samples, and lncRNA MALAT1 was finally identified to show considerable discriminating potential to identify responding patients from non-responding patients...
February 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28184940/circular-rna-and-gene-expression-profiles-in-gastric-cancer-based-on-microarray-chip-technology
#13
Weiguo Sui, Zhoufang Shi, Wen Xue, Minglin Ou, Ying Zhu, Jiejing Chen, Hua Lin, Fuhua Liu, Yong Dai
The aim of the present study was to screen gastric cancer (GC) tissue and adjacent tissue for differences in mRNA and circular (circRNA) expression, to analyze the differences in circRNA and mRNA expression, and to investigate the circRNA expression in gastric carcinoma and its mechanism. circRNA and mRNA differential expression profiles generated using Agilent microarray technology were analyzed in the GC tissues and adjacent tissues. qRT-PCR was used to verify the differential expression of circRNAs and mRNAs according to the interactions between circRNAs and miRNAs as well as the possible existence of miRNA and mRNA interactions...
March 2017: Oncology Reports
https://www.readbyqxmd.com/read/28176360/long-non-coding-rna-malat1-promotes-proliferation-angiogenesis-and-immunosuppressive-properties-of-mesenchymal-stem-cells-by-inducing-vegf-and-ido
#14
Xiujun Li, Yuxian Song, Fei Liu, Dan Liu, Huishuang Miao, Jing Ren, Jingjing Xu, Liang Ding, Yali Hu, Zhiqun Wang, Yayi Hou, Guangfeng Zhao
Mesenchymal stem cells (MSCs) play an important role in regulating angiogenesis and immune balance. The abnormal MSCs in proliferation and function were reported at maternal fetal interface in patients with pre-eclampsia (PE). Long non-coding RNA MALAT1 was known to regulate the function of trophoblast cells. However, it is not clear whether MALAT1 regulates MSCs to be related to PE. In the present study, we found that the expression of MALAT1 was significantly reduced in both umbilical cord tissues and MSCs in patients with severe PE...
February 8, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28165557/il-6-induced-lncrna-malat1-enhances-tnf-%C3%AE-expression-in-lps-induced-septic-cardiomyocytes-via-activation-of-saa3
#15
Y-T Zhuang, D-Y Xu, G-Y Wang, J-L Sun, Y Huang, S-Z Wang
OBJECTIVE: This study aimed to explore the expression of MALAT1 and its correlation with TNF-α production in lipopolysaccharide (LPS)-induced septic cardiomyocytes. Then, the effect of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) on LPS-induced cardiomyocyte apoptosis is further studied. MATERIALS AND METHODS: The hub genes in cell response to LPS treatments was analyzed by using Affymetrix gene profiling data downloaded from GEO dataset (GSE3140)...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28160461/foxo1-malat1-mir-26a-5p-feedback-loop-mediates-proliferation-and-migration-in-osteosarcoma-cells
#16
Juntao Wang, Guodong Sun
MiR-26a has been found to be downregulated in osteosarcoma (OS) compared with normal control tissues and has been shownto be able to suppress the malignant behaviors of OS cells. The underlying mechanism, nevertheless, remains unknown. Here, in our study, the long non-coding RNA MALAT1, confirmed to be significantly up-regulated in OS, was firstly shown to be capable of promoting proliferation and migration by directly suppressing miR-26a-5p in OS cells. In addition, we've identified Forkhead Box O 1 (FOXO1) was a transcriptional factor of MALAT1 that can negatively regulate MALAT1...
February 3, 2017: Oncology Research
https://www.readbyqxmd.com/read/28150831/microrna-mediated-silence-of-onco-lncrna-malat1-in-different-escc-cells-via-ligand-functionalized-hydroxyl-rich-nanovectors
#17
Rui-Quan Li, Yanli Ren, Wenjuan Liu, Wenting Pan, Fu-Jian Xu, Ming Yang
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies worldwide. Long noncoding RNA (lncRNA) MALAT1 acts as an essential oncogene lncRNA (onco-lncRNA) in the development of ESCC. Down-regulation of onco-lncRNA MALAT1 mediated by microRNA-101 (miR-101) and microRNA-217 (miR-217) has been proved to effectively suppress ESCC. In this study, poly(glycidyl methacrylate)-based star-like polycations with flanking folic acid (FA) ligands and rich hydrophilic hydroxyl groups (denoted as s-PGEA-FA) were proposed as efficient nanovectors to deliver miR-101 and miR-217 for silencing onco-lncRNA MALAT1 in different ESCC cells...
February 2, 2017: Nanoscale
https://www.readbyqxmd.com/read/28132817/systematic-mapping-of-rna-chromatin-interactions-in%C3%A2-vivo
#18
Bharat Sridhar, Marcelo Rivas-Astroza, Tri C Nguyen, Weizhong Chen, Zhangming Yan, Xiaoyi Cao, Lucie Hebert, Sheng Zhong
RNA molecules can attach to chromatin. It remains difficult to know what RNAs are associated with chromatin and where the genomic target loci of these RNAs are. Here, we present MARGI (mapping RNA-genome interactions), a technology to massively reveal native RNA-chromatin interactions from unperturbed cells. The gist of this technology is to ligate chromatin-associated RNAs (caRNAs) with their target genomic sequences by proximity ligation, forming RNA-DNA chimeric sequences, which are converted to a sequencing library for paired-end sequencing...
February 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/28128360/discovery-of-cancer-driver-long-noncoding-rnas-across-1112-tumour-genomes-new-candidates-and-distinguishing-features
#19
Andrés Lanzós, Joana Carlevaro-Fita, Loris Mularoni, Ferran Reverter, Emilio Palumbo, Roderic Guigó, Rory Johnson
Long noncoding RNAs (lncRNAs) represent a vast unexplored genetic space that may hold missing drivers of tumourigenesis, but few such "driver lncRNAs" are known. Until now, they have been discovered through changes in expression, leading to problems in distinguishing between causative roles and passenger effects. We here present a different approach for driver lncRNA discovery using mutational patterns in tumour DNA. Our pipeline, ExInAtor, identifies genes with excess load of somatic single nucleotide variants (SNVs) across panels of tumour genomes...
January 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28121347/the-use-of-lncrna-analysis-for-stratification-management-of-prognostic-risk-in-patients-with-nsclc
#20
C-G Zhang, D-D Yin, S-Y Sun, L Han
OBJECTIVE: Lung cancer is the most frequent cancer in China and worldwide. Long noncoding RNAs (lncRNAs) have been shown to play important regulatory roles in human cancer biology. The aim of the present study was to investigate the relationship between genomics and prognosis among lung cancer patients. PATIENTS AND METHODS: We collected specimens from non-small cell lung cancer (NSCLC) patients after surgery. Q-PCR was performed to investigate the expression level of lncRNAs in cancerous and adjacent normal tissue...
January 2017: European Review for Medical and Pharmacological Sciences
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