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https://www.readbyqxmd.com/read/29776371/lncrna-tug1-promoted-kiaa1199-expression-via-mir-600-to-accelerate-cell-metastasis-and-epithelial-mesenchymal-transition-in-colorectal-cancer
#1
Junfeng Sun, Jiyi Hu, Guojun Wang, Zhen Yang, Chunlin Zhao, Xiefu Zhang, Jiaxiang Wang
BACKGROUND: LncRNA TUG1 has been reported to be highly expressed in CRC samples and cells and promoted metastasis by affecting EMT, indicating a poor prognosis for colorectal cancer (CRC). In this study, we determined the underlying mechanism for tumor oncogenesis of lncRNA TUG1 in CRC metastasis. METHODS: The expressions of miR-600 and KIAA1199 in 76 CRC patients and CRC cells and CRC metastatic tissues were determined using qRT-PCR. Epithelial-mesenchymal transition (EMT)-related proteins were determined using western blot...
May 18, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29758198/the-lncrna-tug1-mir-145-5p-fgf10-regulates-proliferation-and-migration-in-vsmcs-of-hypertension
#2
Lin Shi, Caijun Tian, Lingzhi Sun, Feifei Cao, Zhaoyang Meng
Vascular remodeling is a characteristic pathological feature of hypertension, it can cause of increasing vascular resistance and decrease of compliance. Vascular smooth muscle cell (VSMCs) dysfunction is the important foundation of vascular remodeling. Increasing evidences have revealed that lncRNA is an important regulatory factor of VSMC function. In this paper, we explored the function of lncRNA TUG1 in vascular remodeling of hypertension. Here, we found that lncRNA TUG1 was highly expressed in aorta of spontaneously hypertensive rats (SHR) rats and promoted the proliferation and migration of VSMCs (SHR-VSMCs)...
May 11, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29742691/long-non-coding-rna-taurine-upregulated-gene-1-predicts-unfavorable-prognosis-promotes-cells-proliferation-and-inhibits-cells-apoptosis-in-epithelial-ovarian-cancer
#3
Tong-Huai Li, Jing-Jing Zhang, Shao-Xiao Liu, Yan Chen
The aim of this study was to evaluate the correlation of long non-coding RNAs (lncRNAs) taurine-upregulated gene 1 (TUG1) with clinicopathological characteristics as well as overall survival (OS) in epithelial ovarian cancer (EOC) patients, and investigate its function in EOC cells proliferation and apoptosis in vitro.LncRNA TUG1 expressions were detected in tumor tissues and paired adjacent tissues obtained from 96 EOC patients. Blank mimic, lncRNA TUG1 mimic, blank inhibitor, and lncRNA TUG1 inhibitor plasmids were transfected into SKOV3 cells...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29719612/comprehensive-analysis-of-aberrantly-expressed-lncrnas-and-construction-of-cerna-network-in-gastric-cancer
#4
Kanagaraj Arun, Ganesan Arunkumar, Duraisamy Bennet, Servarayan Murugesan Chandramohan, Avaniyapuram Kannan Murugan, Arasambattu Kannan Munirajan
Gastric cancer remains fifth most common cancer often diagnosed at an advanced stage and is the second leading cause of cancer-related death worldwide. Long non-coding RNAs (lncRNAs) involved in various cellular pathways are essential for tumor occurrence and progression and they have high potential to promote or suppress the expression of many genes. In this study, we profiled 19 selected cancer-associated lncRNAs in thirty gastric adenocarcinomas and matching normal tissues by qRT-PCR. Our results showed that most of the lncRNAs were significantly upregulated (12/19)...
April 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29710506/emodin-attenuates-apoptosis-and-inflammation-induced-by-lps-through-up-regulating-lncrna-tug1-in-murine-chondrogenic-atdc5-cells
#5
Zhiyuan Liang, Chunfeng Ren
BACKGROUND: Osteoarthritis (OA) is the most frequent arthritic disease that causes disability and reduces life quality. The treatments for OA are conservative and more effective therapy remains to be identified. Herein, we mainly focused on the role of emodin in lipopolysaccharide (LPS)-induced murine chondrogenic ATDC5 cells as well as the underlying mechanisms. METHODS: In vitro cell system to mimic OA was constructed after LPS treatments. Effects of emodin on viability, apoptosis and release of inflammatory cytokines (TNF-α, IL-6 and MCP-1) in LPS-treated ATDC5 cells were measured...
April 23, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29674645/long-noncoding-rna-tug1-facilitates-osteogenic-differentiation-of-periodontal-ligament-stem-cells-via-interacting-with-lin28a
#6
Qin He, Shuangyan Yang, Xiuge Gu, Mengying Li, Chunling Wang, Fulan Wei
Periodontal ligament stem cells (PDLSCs) are mesenchymal stem cells derived from dental tissues with multidirectional differentiation potential and excellent self-renewing ability. Recently, long noncoding RNAs (lncRNAs) have been shown to play important roles in MSC osteogenic differentiation. In this study, we found that taurine upregulated gene 1 (TUG1), an evolutionarily conserved and widely present lncRNA was significantly upregulated in osteogenically induced PDLSCs compared to their undifferentiated counterparts...
April 19, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29657297/long-non-coding-rna-tug1-expression-is-associated-with-different-subtypes-in-human-breast-cancer
#7
Daniela F Gradia, Carolina Mathias, Rodrigo Coutinho, Iglenir J Cavalli, Enilze M S F Ribeiro, Jaqueline C de Oliveira
Taurine upregulated 1 gene ( TUG1 ) is a long non-coding RNA associated with several types of cancer. Recently, differential expression of TUG1 was found in cancerous breast tissues and associated with breast cancer malignancy features. Although this is evidence of a potential role in breast cancer, TUG1 expression could not be associated with different subtypes, possibly due to the small number of samples analyzed. Breast cancer is a heterogeneous disease and, based on molecular signatures, may be classified into different subtypes with prognostic implications...
December 20, 2017: Non-Coding RNA
https://www.readbyqxmd.com/read/29617668/pan-cancer-analysis-of-lncrna-regulation-supports-their-targeting-of-cancer-genes-in-each-tumor-context
#8
Hua-Sheng Chiu, Sonal Somvanshi, Ektaben Patel, Ting-Wen Chen, Vivek P Singh, Barry Zorman, Sagar L Patil, Yinghong Pan, Sujash S Chatterjee, Anil K Sood, Preethi H Gunaratne, Pavel Sumazin
Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) by modeling their effects on the activity of transcription factors, RNA-binding proteins, and microRNAs in 5,185 TCGA tumors and 1,019 ENCODE assays. Our predictions included hundreds of candidate onco- and tumor-suppressor lncRNAs (cancer lncRNAs) whose somatic alterations account for the dysregulation of dozens of cancer genes and pathways in each of 14 tumor contexts...
April 3, 2018: Cell Reports
https://www.readbyqxmd.com/read/29543785/long-noncoding-rna-taurine-upregulated-gene1-tug1-promotes-tumor-growth-and-metastasis-through-tug1-mir-129-5p-astrocyte-elevated-gene-1-aeg-1-axis-in-malignant-melanoma
#9
Jianwen Long, Qiqige Menggen, Qimige Wuren, Quan Shi, Xianming Pi
BACKGROUND Malignant melanoma is a class of malignant tumors derived from melanocytes. lncRNAs have been considered as pro-/anti-tumor factors in progression of cancers. The function of lncRNA TUG1 on growth of melanoma was investigated in this study. MATERIAL AND METHODS The TUG1 and miR-129-5p expression were examined via qRT-PCR. The protein expression was investigated by Western blotting assay. Luciferase reporter assay was used to assess if lncRNA TUG1 can bind to miR-129-5p and if miR-129-5p can target AEG1 mRNA...
March 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29518613/long-non-coding-rna-tug1-inhibits-apoptosis-and-inflammatory-response-in-lps-treated-h9c2-cells-by-down-regulation-of-mir-29b
#10
Haifang Zhang, Hui Li, Ang Ge, Enyu Guo, Shuxia Liu, Lijuan Zhang
OBJECTIVE: Myocarditis is an important cause for cardiovascular morbidity and mortality in children and adults. The lncRNA taurine up-regulated gene 1 (TUG1) plays important roles in cell apoptosis and inflammation in tumor and liver injury. The present study aimed to investigate the role of TUG1 in LPS-injured H9c2 cells and explore the underlying molecular mechanism. METHODS: H9c2 cells were stimulated with LPS to induce inflammatory injury. The expression of TUG1 was altered by transient transfections...
May 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29516510/integrated-analysis-of-long-noncoding-rna-associated-competing-endogenous-rna-network-in-periodontitis
#11
S Li, X Liu, H Li, H Pan, A Acharya, Y Deng, Y Yu, R Haak, J Schmidt, G Schmalz, D Ziebolz
BACKGROUND AND OBJECTIVES: Long noncoding RNAs (lncRNAs) play critical and complex roles in regulating various biological processes of periodontitis. This bioinformatic study aims to construct a putative competing endogenous RNA (ceRNA) network by integrating lncRNA, miRNA and mRNA expression, based on high-throughput RNA sequencing and microarray data about periodontitis. MATERIAL AND METHODS: Data from 1 miRNA and 3 mRNA expression profiles were obtained to construct the lncRNA-associated ceRNA network...
March 8, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29467911/downregulation-of-the-long-non-coding-rna-taurine-upregulated-gene-1-inhibits-glioma-cell-proliferation-and-invasion-and-promotes-apoptosis
#12
Zhijun Zhao, Bin Wang, Junhai Hao, Weitao Man, Yongkai Chang, Shunchang Ma, Yeshuai Hu, Fusheng Liu, Jun Yang
Expression of the long non-coding RNA taurine-upregulated gene 1 (TUG1) is associated with various aggressive tumors. The present study aimed to investigate the biological function of TUG1 in regulating apoptosis, proliferation, invasion and cell cycle distribution in human glioma U251 cells. Lentivirus-mediated TUG1-specific microRNA was transfected into U251 cells to abrogate the expression of TUG1. Flow cytometry analysis was used to examine the cell cycle distribution and apoptosis of U251 cells. Cellular proliferation was examined using Cell Counting Kit-8 (CCK-8) assays and invasion was examined by Transwell assays...
March 2018: Oncology Letters
https://www.readbyqxmd.com/read/29449542/long-non-coding-rnas-in-ischemic-stroke
#13
REVIEW
Mei-Hua Bao, Vivian Szeto, Burton B Yang, Shu-Zhen Zhu, Hong-Shuo Sun, Zhong-Ping Feng
Stroke is one of the leading causes of mortality and disability worldwide. Uncovering the cellular and molecular pathophysiological processes in stroke have been a top priority. Long non-coding (lnc) RNAs play critical roles in different kinds of diseases. In recent years, a bulk of aberrantly expressed lncRNAs have been screened out in ischemic stroke patients or ischemia insulted animals using new technologies such as RNA-seq, deep sequencing, and microarrays. Nine specific lncRNAs, antisense non-coding RNA in the INK4 locus (ANRIL), metastasis-associate lung adenocarcinoma transcript 1 (MALAT1), N1LR, maternally expressed gene 3 (MEG3), H19, CaMK2D-associated transcript 1 (C2dat1), Fos downstream transcript (FosDT), small nucleolar RNA host gene 14 (SNHG14), and taurine-upregulated gene 1 (TUG1), were found increased in cerebral ischemic animals and/or oxygen-glucose deprived (OGD) cells...
February 15, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29436190/long-non-coding-rna-tug1-promotes-proliferation-and-inhibits-apoptosis-of-osteosarcoma-cells-by-sponging-mir-132-3p-and-upregulating-sox4-expression
#14
Gang Li, Keyu Liu, Xinhui Du
PURPOSE: Long non-coding RNA taurine upregulated gene 1 (TUG1) is reported to be a vital regulator of the progression of various cancers. This study aimed to explore the exact roles and molecular mechanisms of TUG1 in osteosarcoma (OS) development. MATERIALS AND METHODS: Real-time quantitative PCR was applied to detect the expressions of TUG1 and microRNA-132-3p (miR-132-3p) in OS tissues and cells. Western blot was performed to measure protein levels of sex determining region Y-box 4 (SOX4)...
March 2018: Yonsei Medical Journal
https://www.readbyqxmd.com/read/29371936/lncrna-tug1-sponges-mir-145-to-promote-cancer-progression-and-regulate-glutamine-metabolism-via-sirt3-gdh-axis
#15
Bing Zeng, Huilin Ye, Jianming Chen, Di Cheng, Canfeng Cai, Guoxing Chen, Xiang Chen, Haiyang Xin, Chaoming Tang, Jun Zeng
Long noncoding RNAs (lncRNAs) are important regulators in cancer progression. Deregulation of the lncRNA taurine upregulated gene 1 (TUG1) predicts poor prognosis and is implicated in the development of several cancers. In this study, we investigated the role of TUG1 in the pathogenesis of intrahepatic cholangiocarcinoma (ICC). We found that TUG1 is upregulated in ICC samples, which correlates with poor prognosis and adverse clinical pathological characteristics. Knockdown of TUG1 inhibited the proliferation, motility, and invasiveness of cultured ICC cells, and decreased tumor burden in a xenograft mouse model...
December 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/29321088/upregulation-of-long-non-coding-rna-tug1-promotes-bladder-cancer-cell-5-proliferation-migration-and-invasion-by-inhibiting-mir-29c
#16
Peng Guo, Guohui Zhang, Jialin Meng, Qian He, Zhihui Li, Yawei Guan
Bladder cancer (BC) is one of the leading causes of cancer-related death in the word. Long non-coding RNA (lncRNA) taurine-upregulated gene 1 (TUG1) plays an important role in the development and progression of numerous cancers, including BC. However, the exact role of TUG1 in modulating BC progression is still poorly known. In this study, we found that TUG1 was upregulated and microRNA-29c (miR-29c) was downregulated in BC tissues and cell lines. Overexpression of TUG1 promoted the cell proliferation of T24 and EJ cells, whereas TUG1 knockdown had the opposite effect...
January 10, 2018: Oncology Research
https://www.readbyqxmd.com/read/29277771/effects-of-sirna-silencing-of-tug1-and-lcal6-long-non-coding-rnas-on-patient-derived-xenograft-of-non-small-cell-lung-cancer
#17
Tian Fang, Hairong Huang, Xiaoyou Li, Jing Liao, Zhijian Yang, Robert M Hoffman, X I Cheng, Lei Liang, Wenjuan Hu, Shifeng Yun
BACKGROUND/AIM: The aim of the present study was to establish a patient-derived xenograft (PDX) mouse model of non-small cell lung cancer (NSCLC) and investigate the anti-tumor efficacy of silencing of TUG1 and LCAL6 long non-coding RNA in the PDX model. MATERIALS AND METHODS: PDXs were established by subcutaneously implanting NSCLC surgical tumor fragments into immunodeficient mice. PDX characterization was performed by histopathological, immunohistochemical and real-time polymerase chain reaction (RT-PCR) analyses for NSCLC subtype-specific markers and expression of LCAL6 and TUG1...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29245996/prognostic-role-of-long-non-coding-rna-tug1-expression-in-various-cancers-a-meta-analysis
#18
Yongping Zhou, Yuxuan Lu, Runmin Li, Nana Yan, Xiding Li, Tu Dai
Several studies were conducted to explore the prognostic role of long non-coding RNA taurine upregulated gene 1 (lncRNA TUG1) expression in various cancers, with contradictory. This study aims to summarize the prognostic role of lncRNA TUG1 expression in various cancers. Embase, PubMed and Cochrane Library were completely retrieved. The cohort studies focusing on the prognostic role of lncRNA TUG1 expression in various cancers were eligible. The endpoints were overall survival (OS) and clinicopathological parameters...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211876/interplay-between-fmrp-and-lncrna-tug1-regulates-axonal-development-through-mediating-snon-ccd1-pathway
#19
Ye Guo, Xu Chen, Ruxiao Xing, Min Wang, Xiaojuan Zhu, Weixiang Guo
LncRNAs have recently emerged to influence the pathogenesis of fragile X syndrome (FXS), which is caused by the functional loss of fragile X mental retardation protein (FMRP). However, the interaction between FMRP and lncRNAs on regulating neuronal development remains elusive. Here, we reported that FMRP directly interacted with lncRNA TUG1, and decreased its stability. Furthermore, TUG1 bond to transcriptional regulator, SnoN, and negatively modulated SnoN-Ccd1 pathway to specifically control axonal development...
February 1, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29207102/lncrna-tug1-serves-an-important-role-in-hypoxia-induced-myocardial-cell-injury-by-regulating-the-mir%C3%A2-145%C3%A2-5p%C3%A2-binp3-axis
#20
Zhongwei Wu, Shengji Zhao, Chunfu Li, Chaoquan Liu
The aim of the present study was to investigate the function of long non‑coding RNA TUG1 in hypoxia‑induced myocardial cell injury and to explore the potential molecular mechanisms. The cardiomyocyte cell line H9c2 was cultured under hypoxic and normoxic conditions. TUG1 expression under hypoxic conditions was then detected. The effects of TUG1 overexpression on viability, apoptosis, migration and invasion were assayed. In addition, the microRNA (miR)‑145‑5p expression was detected. Following H9c2 cell transfection with miR‑145‑5p mimics, the H9c2 cell viability, apoptosis, migration and invasion were also detected...
February 2018: Molecular Medicine Reports
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