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https://www.readbyqxmd.com/read/29321088/upregulation-of-long-non-coding-rna-tug1-promotes-bladder-cancer-cell-5-proliferation-migration-and-invasion-by-inhibiting-mir-29c
#1
Peng Guo, Guohui Zhang, Jialin Meng, Qian He, Zhihui Li, Yawei Guan
Bladder cancer (BC) is one of the leading causes of cancer-related death in the word. Long non-coding RNA (lncRNA) taurine-upregulated gene 1 (TUG1) plays an important role in the development and progression of numerous cancers, including BC. However, the exact role of TUG1 in modulating BC progression is still poorly known. In this study, we found that TUG1 was upregulated and microRNA-29c (miR-29c) was downregulated in BC tissues and cell lines. Overexpression of TUG1 promoted the cell proliferation of T24 and EJ cells, whereas TUG1 knockdown had the opposite effect...
January 10, 2018: Oncology Research
https://www.readbyqxmd.com/read/29277771/effects-of-sirna-silencing-of-tug1-and-lcal6-long-non-coding-rnas-on-patient-derived-xenograft-of-non-small-cell-lung-cancer
#2
Tian Fang, Hairong Huang, Xiaoyou Li, Jing Liao, Zhijian Yang, Robert M Hoffman, X I Cheng, Lei Liang, Wenjuan Hu, Shifeng Yun
BACKGROUND/AIM: The aim of the present study was to establish a patient-derived xenograft (PDX) mouse model of non-small cell lung cancer (NSCLC) and investigate the anti-tumor efficacy of silencing of TUG1 and LCAL6 long non-coding RNA in the PDX model. MATERIALS AND METHODS: PDXs were established by subcutaneously implanting NSCLC surgical tumor fragments into immunodeficient mice. PDX characterization was performed by histopathological, immunohistochemical and real-time polymerase chain reaction (RT-PCR) analyses for NSCLC subtype-specific markers and expression of LCAL6 and TUG1...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29245996/prognostic-role-of-long-non-coding-rna-tug1-expression-in-various-cancers-a-meta-analysis
#3
Yongping Zhou, Yuxuan Lu, Runmin Li, Nana Yan, Xiding Li, Tu Dai
Several studies were conducted to explore the prognostic role of long non-coding RNA taurine upregulated gene 1 (lncRNA TUG1) expression in various cancers, with contradictory. This study aims to summarize the prognostic role of lncRNA TUG1 expression in various cancers. Embase, PubMed and Cochrane Library were completely retrieved. The cohort studies focusing on the prognostic role of lncRNA TUG1 expression in various cancers were eligible. The endpoints were overall survival (OS) and clinicopathological parameters...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29211876/interplay-between-fmrp-and-lncrna-tug1-regulates-axonal-development-through-mediating-snon-ccd1-pathway
#4
Ye Guo, Xu Chen, Ruxiao Xing, Min Wang, Xiaojuan Zhu, Weixiang Guo
LncRNAs have recently emerged to influence the pathogenesis of fragile X syndrome (FXS), which is caused by the functional loss of fragile X mental retardation protein (FMRP). However, the interaction between FMRP and lncRNAs on regulating neuronal development remains elusive. Here, we reported that FMRP directly interacted with lncRNA TUG1, and decreased its stability. Furthermore, TUG1 bond to transcriptional regulator, SnoN, and negatively modulated SnoN-Ccd1 pathway to specifically control axonal development...
December 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/29207102/lncrna-tug1-serves-an-important-role-in-hypoxia-induced-myocardial-cell-injury-by-regulating-the-mir%C3%A2-145%C3%A2-5p%C3%A2-binp3-axis
#5
Zhongwei Wu, Shengji Zhao, Chunfu Li, Chaoquan Liu
The aim of the present study was to investigate the function of long non‑coding RNA TUG1 in hypoxia‑induced myocardial cell injury and to explore the potential molecular mechanisms. The cardiomyocyte cell line H9c2 was cultured under hypoxic and normoxic conditions. TUG1 expression under hypoxic conditions was then detected. The effects of TUG1 overexpression on viability, apoptosis, migration and invasion were assayed. In addition, the microRNA (miR)‑145‑5p expression was detected. Following H9c2 cell transfection with miR‑145‑5p mimics, the H9c2 cell viability, apoptosis, migration and invasion were also detected...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29184421/lncrna-expression-and-implication-in-osteosarcoma-a-systematic-review-and-meta-analysis
#6
Ying Wang, Yuelong Huang, Peng Xiang, Wei Tian
Purpose: Osteosarcoma is the most prevalent primary bone tumor in children, adolescents, and older adults, typically presenting with poor survival outcomes. In recent years, ample evidence has shown that many long noncoding RNAs (lncRNAs) have been aberrantly expressed in osteosarcoma, demonstrating their potential to serve as prognostic markers. In this study, we performed a meta-analysis on four lncRNAs (TUG1, UCA1, BCAR4, and HULC) to systematically evaluate their prognostic value in osteosarcoma...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29182008/aberrant-expression-of-plncrna-1-and-tug1-potential-biomarkers-for-gastric-cancer-diagnosis-and-clinically-monitoring-cancer-progression
#7
Zohreh Baratieh, Zahra Khalaj, Mohammad Amin Honardoost, Modjtaba Emadi-Baygi, Hossein Khanahmad, Mansoor Salehi, Parvaneh Nikpour
AIM: To evaluate PlncRNA-1, TUG1 and FAM83H-AS1 gene expression and their possible role as a biomarker in gastric cancer (GC) progression. PATIENTS & METHODS: Long noncoding RNA expressions and clinicopathological characteristics were assessed in 70 paired GC tissues. Furthermore, corresponding data from 318 GC patients were downloaded from The Cancer Genome Atlas database. RESULTS: Expression of PlncRNA-1 and TUG1 were significantly upregulated in GC tumoral tissues, and significantly correlated with clinicopathological characters...
November 28, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/29179467/knockdown-of-long-non-coding-rna-taurine-up-regulated-1-inhibited-doxorubicin-resistance-of-bladder-urothelial-carcinoma-via-wnt-%C3%AE-catenin-pathway
#8
Dalong Xie, Hui Zhang, Xuanhao Hu, Chao Shang
In genitourinary system, bladder cancer (BC) is the most common and lethal malignant tumor, which most common type is bladder urothelial carcinoma (BUC). Long non-coding RNA (lncRNA) Taurine Up-Regulated 1 (TUG1) gene is high-expressed in several malignant tumors, including BC. In this study, over-expression of TUG1 was found in BUC tissues and cell line resistant to doxorubicin (Dox). Knockdown of TUG1 inhibited the Dox resistance and promoted the cytotoxicity induced by Dox in T24/Dox cells. TUG1 knockdown also depressed the Wnt/β-catenin pathway, and the activation the Wnt/β-catenin pathway partly reversed the inhibitory effects of TUG1 knockdown on Dox resistance in T24/Dox cells...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29170907/an-immune-related-lncrna-signature-for-patients-with-anaplastic-gliomas
#9
Wen Wang, Zheng Zhao, Fan Yang, Haoyuan Wang, Fan Wu, Tingyu Liang, Xiaoyan Yan, Jiye Li, Qing Lan, Jiangfei Wang, Jizong Zhao
We investigated immune-related long non-coding RNAs (lncRNAs) that may be exploited as potential therapeutic targets in anaplastic gliomas. We obtained 572 lncRNAs and 317 immune genes from the Chinese Glioma Genome Atlas microarray and constructed immune-related lncRNAs co-expression networks to identify immune-related lncRNAs. Two additional datasets (GSE16011, REMBRANDT) were used for validation. Gene set enrichment analysis and principal component analysis were used for functional annotation. Immune-lncRNAs co-expression networks were constructed...
November 23, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29145271/tug1-spry4-it1-and-hulc-as-valuable-prognostic-biomarkers-of-survival-in-cancer-a-prisma-compliant-meta-analysis
#10
Yucheng Zhong, Zhicong Chen, Shuyuan Guo, Xinhui Liao, Haibiao Xie, Yien Zheng, Bin Cai, Peixian Huang, Yuhan Liu, Qun Zhou, Yuchen Liu, Weiren Huang
BACKGROUND: Long noncoding RNAs (LncRNAs) are involved in the development and progression of various cancers. Accumulating evidences indicated that expression of lncRNAs was related to the prognosis of tumors. METHODS: Here, 3 well-known lncRNAs associated with cancer were gathered to prove the potential role of lncRNAs as novel predictors of survival in human cancer. This meta-analysis collected all eligible studies about TUG1, SPRY4-IT1, and HULC and explored the relationship between lncRNAs expression and lymph node metastasis (LNM) or overall survival (OS)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29137430/genome-wide-analysis-and-functional-prediction-of-long-non-coding-rnas-in-mouse-uterus-during-the-implantation-window
#11
Qi Wang, Nan Wang, Rui Cai, Fan Zhao, Yongjie Xiong, Xiao Li, Aihua Wang, Pengfei Lin, Yaping Jin
Establishment of the receptive uterus is a crucial step for embryo implantation. In this study, the expression profiles and characterization of long non-coding RNAs (lncRNAs) in pregnant mouse uteri on day 4, day 5 at implantation sites and inter-implantation sites were conducted using RNA-seq. A total of 7,764 putative lncRNA transcripts were identified, including 6,179 known lncRNA transcripts and 1,585 novel lncRNA transcripts. Bioinformatics analysis of the cis and trans lncRNA targets showed that the differentially expressed lncRNAs were mainly involved in tissue remodelling, immune response and metabolism-related processes, indicating that lncRNAs could be involved in the regulation of embryo implantation...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029483/the-long-noncoding-rna-tug1-acts-as-a-competing-endogenous-rna-to-regulate-the-hedgehog-pathway-by-targeting-mir-132-in-hepatocellular-carcinoma
#12
Jingjing Li, Qinghui Zhang, Xiaoming Fan, Wenhui Mo, Weiqi Dai, Jiao Feng, Liwei Wu, Tong Liu, Sainan Li, Shizan Xu, Wenwen Wang, Xiya Lu, Qiang Yu, Kan Chen, Yujing Xia, Jie Lu, Yingqun Zhou, Ling Xu, Chuanyong Guo
Emerging evidence shows that the Hedgehog pathway and the long noncoding RNA TUG1 play pivotal roles in cell proliferation, migration, and invasion in tumors. However, the mechanism underlying the effect of TUG1 and the Hedgehog pathway in hepatoma remains undefined. In the present study, we showed that the expression of TUG1 was negatively correlated with that of microRNA (miR)-132, and depletion of TUG1 inhibited the activation of the Hedgehog pathway in vitro and in vivo. We showed that TUG1 functions as a competing endogenous (ceRNA) by competing with miR-132 for binding to the sonic hedgehog protein in HCC, thereby suppressing the activation of Hedgehog signaling and its tumorigenic effect...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029475/the-prognostic-potential-and-carcinogenesis-of-long-non-coding-rna-tug1-in-human-cholangiocarcinoma
#13
Yi Xu, Kaiming Leng, Zhenglong Li, Fumin Zhang, Xiangyu Zhong, Pengcheng Kang, Xingming Jiang, Yunfu Cui
Cholangiocarcinoma (CCA) is a fatal disease with increasing worldwide incidence and is characterized by poor prognosis due to its poor response to conventional chemotherapy or radiotherapy. Long non-coding RNAs (lncRNAs) play key roles in multiple human cancers, including CCA. Cancer progression related lncRNA taurine-up-regulated gene 1 (TUG1) was reported to be involved in human carcinomas. However, the impact of TUG1 in CCA is unclear. The aim of this study was to explore the expression pattern of TUG1 and evaluate its clinical significance as well as prognostic potential in CCA...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029461/prognostic-value-of-long-non-coding-rna-tug1-in-various-tumors
#14
Na Li, Ke Shi, Xinmei Kang, Wei Li
Taurine up-regulated gene 1 (TUG1) is a long non-coding RNA (lncRNA), has been reported that be dysregulated in various tumors, involved in proliferation and apoptosis in a variety of tumor cells. To detect the clinical significance of TUG1 expression in tumor patients, we carried out current systematic review and meta-analysis investigating its relation with the prognosis and clinicopathological features of cancers. A total of 15 studies comprise 1560 patients were analyzed. The pooled results showed that no significant relationship between high TUG1 expression and overall survival (OS) (HR = 1...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29029428/long-non-coding-rna-tug1-promotes-cervical-cancer-progression-by-regulating-the-mir-138-5p-sirt1-axis
#15
Jie Zhu, Huirong Shi, Huina Liu, Xiaojuan Wang, Fengmei Li
Increasing evidences showed that long non-coding RNAs (lncRNAs) play vital roles in tumor progression. Recent studies indicated that lncRNA TUG1 was upregulated and promoted tumor processes in several cancers. However, the expression and underlying mechanism of TUG1 in cervical cancer remain unclear. In the present study, we found that TUG1 expression was upregulated in cervical cancer tissues and correlated with advanced clinical features and poor overall survival. TUG1 knockdown suppressed cervical cancer cell growth and metastasis in vitro and tumor growth in vivo...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29022920/the-lncrna-tug1-modulates-proliferation-in-trophoblast-cells-via-epigenetic-suppression-of-rnd3
#16
Yetao Xu, Zhiping Ge, Erbao Zhang, Qing Zuo, Shiyun Huang, Nana Yang, Dan Wu, Yuanyuan Zhang, Yanzi Chen, Haoqin Xu, Huan Huang, Zhiyan Jiang, Lizhou Sun
Due to limited treatment options, pre-eclampsia (PE) is associated with fetal perinatal and maternal morbidity and mortality. During the causes of PE, failure of uterine spiral artery remodeling which might be related to functioning abnormally of trophoblast cells, result in the occurrence and progression of PE. Recently, abnormal expression of long non-coding RNAs (lncRNAs), as imperative regulators involved in human diseases progression (included PE), which has been indicated by increasing evidence. In this research, we found that TUG1, a lncRNA, was markedly reduced in placental samples from patients with PE...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/29016735/lncrna-tug1-sponges-mir-204-5p-to-promote-osteoblast-differentiation-through-upregulating-runx2-in-aortic-valve-calcification
#17
Cong Yu, Lifu Li, Fei Xie, Shichao Guo, Fayuan Liu, Nianguo Dong, Yongjun Wang
Aims: Emerging evidence indicates that long non-coding RNAs (lncRNAs) play a vital role in cardiovascular physiology and pathology. Although the lncRNA TUG1 is implicated in atherosclerosis, its function in calcific aortic valve disease (CAVD) remains unknown. Methods and Results: In this study, we found that TUG1 was highly expressed in human aortic valves and primary valve interstitial cells (VICs). Moreover, TUG1 knockdown induced inhibition of osteoblast differentiation in CAVD both in vitro and in vivo ...
September 4, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28979812/long-non-coding-rna-tug1-promotes-progression-of-oral-squamous-cell-carcinoma-through-upregulating-fmnl2-by-sponging-mir-219
#18
Guangqi Yan, Xue Wang, Mingliang Yang, Li Lu, Qing Zhou
Oral squamous cell carcinoma (OSCC) is a prevalent oral disease with a high morbidity and mortality rate. Several long non-coding RNAs (lncRNAs) were identified as important regulators of carcinogenesis. However, the pathogenic implications of TUG1 in OSCC are still unclear. In the present study, the expression of TUG1 was increased in OSCC cells. Knockdown of TUG1 inhibited cell proliferation, migration, and invasion, and induced cell cycle arrest at G0/G1 phase, whereas overexpression of TUG1 exerted the opposite effect on OSCC cells...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28977959/long-non-coding-rna-tug1-as-a-potential-prognostic-biomarker-in-human-cancers-a-meta-analysis
#19
Peng-Ju Ma, Qing-Kai Guan, Lei Meng, Nan Qin, Jia Zhao, Bao-Zhe Jin
LncRNA taurine upregulated gene 1 (TUG1) is reportedly dysregulated in various cancers. We performed this meta-analysis to clarify the usefulness of TUG1 as a prognostic marker in malignant tumors. The PubMed, Medline, OVID, Cochrane Library, and Web of Science databases were searched from inception to Jan 11, 2017. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to explore the relationship between TUG1 expression and overall survival (OS). Odds ratios (ORs) were calculated to assess the association between TUG1 expression and pathological parameters...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28950664/downregulation-of-the-long-non-coding-rna-tug1-is-associated-with-cell-proliferation-migration-and-invasion-in-breast-cancer
#20
Shulin Fan, Zhaoying Yang, Zirui Ke, Keke Huang, Ning Liu, Xuedong Fang, Keren Wang
Recent studies have identified many long non-coding RNAs (lncRNAs) with critical roles in various biological processes including tumorigenesis. Taurine-upregulated gene 1 (TUG1), is an lncRNA recently reported to be involved in the progression of several human cancers. This study aimed to investigate the clinical significance and biological functions of TUG1 in breast cancer. Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to measure TUG1 expression in cells from breast cancer cell lines and in 58 matched pairs of breast cancer and normal tissue samples from patients with clinicopathological comparisons...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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