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https://www.readbyqxmd.com/read/29432654/eccrine-sweat-glands-associate-with-the-human-hair-follicle-within-a-defined-compartment-of-dermal-white-adipose-tissue
#1
E Poblet, F Jimenez-Acosta, E Escario-Travesedo, J A Hardman, I Hernández-Hernández, J L Agudo-Mena, J J Cabrera-Galvan, C Nicu, R Paus
BACKGROUND: Eccrine sweat glands (ESGs) are critical for thermoregulation and involved in wound healing. ESGs have traditionally been considered as separate skin appendages without connection to the pilosebaceous unit (PSU). However, recent preliminary evidence has encouraged the hypothesis that PSU and ESG are more interconnected than previously thought. OBJECTIVE: To reevaluate the morphology of human skin adnexa with an integrated 3D perspective in order to explore the possible interconnections that the PSU and the ESG may form...
February 12, 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29403185/standardization-of-smp-procedure-and-its-impact-on-outcome
#2
Rachita S Dhurat, Sujit J S Shanshanwal, Ameet L Dandale
Background: Cosmetic deformities can result from various types of alopecia or even post hair transplantation procedures. Patients with such deformities seek aesthetically appealing longer-lasting options. Scalp concealers are commonly used by men and women to camouflage these deformities. Scalp micropigmentation (SMP) is one of the concealers recently gaining popularity. Objectives: SMP is a novel technique wherein microdot tattoos are placed in a stippling pattern to mimic hair follicles that are cut close to the scalp and various variables affecting its outcome were evaluated...
July 2017: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29392864/an-efficient-method-for-eccrine-gland-isolation-from-human-scalp
#3
F Jimenez, M Alam, I Hernandez, E Poblet, J A Hardman, R Paus
We describe a simple and efficient method to isolate eccrine sweat glands from the human scalp. This method is inspired by the hair graft harvesting method used in hair transplantation. Based on the recently described anatomical relationship between the scalp hair follicle and the eccrine gland, we have found that scalp follicular unit grafts are an excellent eccrine gland isolation source, especially for the coiled component. In order to make the gland visible for stereoscopic microdissection, the follicular units need to be previously stained with a vital dye like Methylene Blue or Neutral Red...
February 2, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29364256/a-protocol-for-decellularizing-mouse-cochleae-for-inner-ear-tissue-engineering
#4
Christopher A Neal, Jennifer G Nelson-Brantley, Michael S Detamore, Hinrich Staecker, Adam J Mellott
In mammals, mechanosensory hair cells that facilitate hearing lack the ability to regenerate, which has limited treatments for hearing loss. Current regenerative medicine strategies have focused on transplanting stem cells or genetic manipulation of surrounding support cells in the inner ear to encourage replacement of damaged stem cells to correct hearing loss. Yet, the extracellular matrix (ECM) may play a vital role in inducing and maintaining function of hair cells, and has not been well investigated. Using the cochlear ECM as a scaffold to grow adult stem cells may provide unique insights into how the composition and architecture of the extracellular environment aids cells in sustaining hearing function...
January 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29363542/ruxolitinib-protects-skin-stem-cells-and-maintains-skin-homeostasis-in-murine-graft-versus-host-disease
#5
Shuichiro Takahashi, Daigo Hashimoto, Eiko Hayase, Reiki Ogasawara, Hiroyuki Ohigashi, Takahide Ara, Emi Yokoyama, Ko Ebata, Satomi Matsuoka, Geoffrey Hill, Junichi Sugita, Masahiro Onozawa, Takanori Teshima
Graft-versus-host disease (GVHD) is the major complication after allogeneic stem cell transplantation (SCT). Emerging evidence indicates that GVHD leads to injury of intestinal stem cells. However, it remains to be investigated whether skin stem cells could be targeted in skin GVHD. Lgr5+ hair follicle stem cells (HFSCs) contribute to folliculogenesis and have a multipotent capacity to regenerate all epithelial cells in repair. We studied the fate of Lgr5+ HFSCs after SCT and explored the novel treatment to protect Lgr5+ HFSCs against GVHD using murine models of SCT...
January 23, 2018: Blood
https://www.readbyqxmd.com/read/29343978/parietal-scalp-is-another-affected-area-in-female-pattern-hair-loss-an-analysis-of-hair-density-and-hair-diameter
#6
Salinee Rojhirunsakool, Poonkiat Suchonwanit
Purpose: Female pattern hair loss (FPHL) is a common hair disease. However, studies of the quantitative measurement of FPHL are still limited. The aim of this study was to investigate the characteristics of hair density and hair diameter in normal women and FPHL patients, and further correlate the quantitative measurement with the clinical presentation of FPHL. Patients and methods: An evaluation of 471 FPHL patients and 236 normal women was carried out according to the Ludwig classification, and analysis was performed by using a com-puterized handheld USB camera with computer-assisted software...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29336472/baicalin-increases-hair-follicle-development-by-increasing-canonical-wnt-%C3%AE-%C3%A2-catenin-signaling-and-activating-dermal-papillar-cells-in-mice
#7
Fei Xing, Wen-Juan Yi, Fang Miao, Meng-Yun Su, Tie-Chi Lei
Baicalin is a traditional Chinese herbal medicine commonly used for hair loss, the precise molecular mechanism of which is unknown. In the present study, the mechanism of baicalin was investigated via the topical application of baicalin to reconstituted hair follicles on mice dorsa and evaluating the effect on canonical Wnt/β‑catenin signaling in the hair follicles and the activity of dermal papillar cells. The results indicate that baicalin stimulates the expression of Wnt3a, Wnt5a, frizzled 7 and disheveled 2 whilst inhibiting the Axin/casein kinase 1α/adenomatous polyposis coli/glycogen synthase kinase 3β degradation complex, leading to accumulation of β‑catenin and activation of Wnt/β‑catenin signaling...
January 16, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29301392/clinical-safety-and-efficacy-of-autologous-bone-marrow-derived-mesenchymal-stem-cell-transplantation-in-sensorineural-hearing-loss-patients
#8
Ho Seok Lee, Woo Jin Kim, Ji Sun Gong, Kyoung Ho Park
Stem cell transplantation represents a promising therapy for several degenerating and necrotic diseases. In several animal studies, we could find hearing restoration after inoculation of the mesenchymal stem cells' as well as mesenchymal stem cells' differentiation of hair cells and spiral ganglion. But until now, no clinical study has been reported directly for the human being. In this pilot studies, we applied mesenchymal stem cells to human beings trans-venously. Although we verified the safety of the autologous bone marrow stem cell transplantation in sensorineural hearing loss patients but we could not achieve significant improvement in hearing...
January 5, 2018: Journal of Audiology & Otology
https://www.readbyqxmd.com/read/29298425/hair-follicle-development-in-mouse-pluripotent-stem-cell-derived-skin-organoids
#9
Jiyoon Lee, Robert Bӧscke, Pei-Ciao Tang, Byron H Hartman, Stefan Heller, Karl R Koehler
The mammalian hair follicle arises during embryonic development from coordinated interactions between the epidermis and dermis. It is currently unclear how to recapitulate hair follicle induction in pluripotent stem cell cultures for use in basic research studies or in vitro drug testing. To date, generation of hair follicles in vitro has only been possible using primary cells isolated from embryonic skin, cultured alone or in a co-culture with stem cell-derived cells, combined with in vivo transplantation...
January 2, 2018: Cell Reports
https://www.readbyqxmd.com/read/29285533/scaffold-assisted-artificial-hair-implantation-in-a-rat-model
#10
Joshua K Au, Miguel Fernando Palma Diaz, Tara Aghaloo, Maie A St John
Importance: Current treatments for alopecia with autograft hair transplantation face limitations that may preclude complete hair restoration and leave patients with donor site scars. Scaffold assisted artificial hair implantation as demonstrated in a rat model may provide an adjunct for hair restoration without donor site morbidity. Objective: To design and create porous high-density polyethylene (PHDPE) and expanded polytetrafluoroethylene (ePTFE) hair-bearing scaffolds and evaluate their biocompatibility in a rat model...
December 28, 2017: JAMA Facial Plastic Surgery
https://www.readbyqxmd.com/read/29227728/use-of-low-level-laser-therapy-in-treatment-of-the-androgenic-alopecia-the-first-systematic-review
#11
Ibrahim Najem, Hongxiang Chen
Alopecia is a common disease affecting more than half of the world total number of people. Alopecia exists in different types, but one of the most common of these types is the Androgenic Alopecia which has affected approximately 51% of the total number of males ranging between the age bracket of 40 years and 75 years. This type of alopecia is more common in females who are above the age of 65 years and above. Despite this widespread effect, much has not been done regarding identifying the possible drugs for treating this disease...
December 11, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29195242/the-role-of-hair-transplantation-for-managing-facial-trauma
#12
Jeffrey S Epstein, Gorana Kuka
No abstract text is available yet for this article.
December 2017: Facial Plastic Surgery: FPS
https://www.readbyqxmd.com/read/29156398/spontaneous-hair-follicle-germ-hfg-formation-in%C3%A2-vitro-enabling-the-large-scale-production-of-hfgs-for-regenerative-medicine
#13
Tatsuto Kageyama, Chisa Yoshimura, Dina Myasnikova, Ken Kataoka, Tadashi Nittami, Shoji Maruo, Junji Fukuda
Hair follicle morphogenesis is triggered by reciprocal interactions between hair follicle germ (HFG) epithelial and mesenchymal layers. Here, we developed a method for large-scale preparation of HFGs in vitro via self-organization of cells. We mixed mouse epidermal and mouse/human mesenchymal cells in suspension and seeded them in microwells of a custom-designed array plate. Over a 3-day culture period, cells initially formed a randomly distributed single cell aggregate and then spatially separated from each other, exhibiting typical HFG morphological features...
November 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/29141069/a-novel-multi-targeting-approach-to-treating-hair-loss-using-standardized-nutraceuticals
#14
Patricia K Farris, Nicole Rogers, Amy McMichael, Sophia Kogan
<p>Hair loss is a complicated problem that causes significant concern for those who are affected. Patients seeking medical treatment have limited options that include topical minoxidil and oral finasteride. While these treatments are backed by long term clinical use and research outcomes, many patients find topical minoxidil difficult to incorporate into their daily routine and some are concerned with the side effects associated with finasteride. In the office setting, patients may be treated with more invasive procedures such as platelet-rich plasma injections (PRP) and hair transplantation, treatments that often must be repeated and can lead to a costly investment...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29108548/new-generation-therapies-for-the-treatment-of-hair-loss-in-men
#15
REVIEW
Neil S Sadick
Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychoemotional well-being. Today hair restoration technologies through hair transplantation have advanced with the use of robots and follicular unit extraction/grafting that can offer patients excellent clinical results. Adjuvant modalities, such as platelet-rich plasma injections, lasers, and stem cells, can further enhance durability, health, and appearance of hair transplants.
January 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29108547/advances-in-hair-restoration
#16
REVIEW
Paul T Rose
Hair loss affects millions of people worldwide and can have devastating effects on an individual's psychological and emotional well-being. Hair restoration technologies have advanced with the use of robotics and manual and motorized follicular unit extraction to provide patients excellent clinical results. Adjuvant modalities such as platelet-rich plasma injections, lasers and stem cells can further enhance the survivability and appearance of hair transplants.
January 2018: Dermatologic Clinics
https://www.readbyqxmd.com/read/29084289/neuronal-differentiation-of-hair-follicle-bulge-derived-stem-cells-co-cultured-with-mouse-cochlear-modiolus-explants
#17
Timo Schomann, Laura Mezzanotte, John C M J De Groot, Marcelo N Rivolta, Sanne H Hendriks, Johan H M Frijns, Margriet A Huisman
Stem-cell-based repair of auditory neurons may represent an attractive therapeutic option to restore sensorineural hearing loss. Hair-follicle-bulge-derived stem cells (HFBSCs) are promising candidates for this type of therapy, because they (1) have migratory properties, enabling migration after transplantation, (2) can differentiate into sensory neurons and glial cells, and (3) can easily be harvested in relatively high numbers. However, HFBSCs have never been used for this purpose. We hypothesized that HFBSCs can be used for cell-based repair of the auditory nerve and we have examined their migration and incorporation into cochlear modiolus explants and their subsequent differentiation...
2017: PloS One
https://www.readbyqxmd.com/read/29076290/the-effect-of-plasma-rich-in-growth-factors-combined-with-follicular-unit-extraction-surgery-for-the-treatment-of-hair-loss-a-pilot-study
#18
Roge M Navarro, Ander Pino, Asunción Martinez-Andres, Consuelo Molina, Ana María Martinez, Nahikari Martinez, Gorka Orive, Eduardo Anitua
BACKGROUND: Hair transplant surgery using follicular unit extraction technique (FUE) is a common surgical procedure for the treatment of severe hair loss. Blood-derived autologous growth factors have also proved to promote hair regeneration in patients with different types of alopecia. AIMS: The aim of this study was to evaluate the safety and clinical efficacy of plasma rich in growth factors (PRGF) technology as an adjuvant therapy for FUE surgery in hair loss affected patients...
October 26, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29064980/hair-transplantation-controversies
#19
REVIEW
Marc R Avram, Robert Finney, Nicole Rogers
BACKGROUND: Hair transplant surgery creates consistently natural appearing transplanted hair for men. It is increasingly popular procedure to restore natural growing hair for men with hair loss. OBJECTIVE: To review some current controversies in hair transplant surgery. MATERIALS AND METHODS: Review of the English PubMed literature and specialty literature in hair transplant surgery. RESULTS: Some of the controversies in hair transplant surgery include appropriate donor harvesting technique including elliptical donor harvesting versus follicular unit extraction whether manual versus robotic, the role of platelet-rich plasma and low-level light surgery in hair transplant surgery...
November 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29062667/hair-transplantation-in-migraine-headache-patients
#20
Safvet Ors
BACKGROUND: Migraine headache is a primary neurologic disease affecting millions of people worldwide. As a consequence, quality of life is diminished, productivity suffers (through loss of work force), and treatment costs are substantial. The occurrence rate in the general population is quite high, with women accounting for 3 of every 4 cases. METHODS: Between January 2011 and May 2012, a total of 221 patients received hair transplants. Another 590 patients underwent hair transplantation between June 2012 and December 2016...
September 2017: Plastic and Reconstructive Surgery. Global Open
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