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freeze dried plasma hemorrhage

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https://www.readbyqxmd.com/read/28601205/remote-damage-control-resuscitation-in-austere-environments
#1
REVIEW
Ronald Chang, Brian J Eastridge, John B Holcomb
Hemorrhage is the leading cause of preventable military and civilian trauma death. Damage control resuscitation with concomitant mechanical hemorrhage control has become the preferred in-hospital treatment of hemorrhagic shock. In particular, plasma-based resuscitation with decreased volumes of crystalloids and artificial colloids as part of damage control resuscitation has improved outcomes in the military and civilian sectors. However, translation of these principles and techniques to the prehospital, remote, and austere environments, known as remote damage control resuscitation, is challenging given the resource limitations in these settings...
June 2017: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/28599038/albumin-for-prehospital-fluid-resuscitation-of-hemorrhagic-shock-in-tactical-combat-casualty-care
#2
Nicholas M Studer, Michael D April, F Bowling, Paul D Danielson, Andrew P Cap
Optimal fluid resuscitation on the battlefield in the absence of blood products remains unclear. Contemporary Combat medics are generally limited to hydroxyethyl starch or crystalloid solutions, both of which present significant drawbacks. Obtaining US Food and Drug Administration (FDA)-approved freeze-dried plasma (FDP) is a top casualty care research priority for the US Military. Interest in this agent reflects a desire to simultaneously expand intravascular volume and address coagulopathy. The history of FDP dates to the Second World War, when American expeditionary forces used this agent frequently...
2017: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
https://www.readbyqxmd.com/read/28590355/pre-hospital-administration-of-freeze-dried-plasma-is-it-the-solution-for-trauma-casualties
#3
Shlaifer Amir, Siman-Tov Maya, Radomislensky Irina, Peleg Kobi, Shina Avi, Baruch N Erez, Glassberg Elon, Yitzhak Avraham
BACKGROUND: Hemorrhage, is the leading cause of possible preventable death in the battlefield. There is an increasing evidence for the effectiveness of blood component therapy in general, and plasma infusion in particular but their use is less applicable in the pre-hospital setting due to logistic difficulties. Israeli Defense Force has implemented the use of freeze dried plasma (FDP) at the point of injury (POI), this adoption of FDP use entailed doubts regarding the feasibility and effectiveness of this practice...
June 6, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28500652/freeze-dried-plasma-enhances-clot-formation-and-inhibits-fibrinolysis-in-the-presence-of-tissue-plasminogen-activator-similar-to-pooled-liquid-plasma
#4
Benjamin R Huebner, Ernest E Moore, Hunter B Moore, Angela Sauaia, Gregory Stettler, Monika Dzieciatkowska, Kirk Hansen, Anirban Banerjee, Christopher C Silliman
BACKGROUND: Systemic hyperfibrinolysis is an integral part of trauma-induced coagulopathy associated with uncontrolled bleeding. Recent data suggest that plasma-first resuscitation attenuates hyperfibrinolysis; however, the availability, transport, storage, and administration of plasma in austere environments remain challenging and have limited its use. Freeze-dried plasma (FDP) is a potential alternative due to ease of storage, longer shelf life, and efficient reconstitution. FDP potentially enhances clot formation and resists breakdown better than normal saline (NS) and albumin and similar to liquid plasma...
May 12, 2017: Transfusion
https://www.readbyqxmd.com/read/27720977/development-of-a-new-polyspecific-antivenom-for-snakebite-envenoming-in-sri-lanka-analysis-of-its-preclinical-efficacy-as-compared-to-a-currently-available-antivenom
#5
Mauren Villalta, Andrés Sánchez, María Herrera, Mariángela Vargas, Álvaro Segura, Maykel Cerdas, Ricardo Estrada, Indika Gawarammana, Dan E Keyler, Kimberly McWhorter, Roy Malleappah, Alberto Alape-Girón, Guillermo León, José María Gutiérrez
A new whole IgG, freeze-dried, polyspecific antivenom was prepared from the plasma of horses immunized with the venoms of the snakes Daboia russelii, Echis carinatus, Hypnale hypnale, and Naja naja from Sri Lanka. The preclinical neutralizing ability of this antivenom against several toxic and enzymatic activities of these four venoms was analyzed, and compared with that of a batch of VINS antivenom (India) being currently used in Sri Lanka. The activities tested were: lethality, hemorrhagic, in vitro coagulant, proteinase and phospholipase A2...
November 2016: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/27380536/plasma-transfusion-history-current-realities-and-novel-improvements
#6
Justin J J Watson, Shibani Pati, Martin A Schreiber
Traumatic hemorrhage is the leading cause of preventable death after trauma. Early transfusion of plasma and balanced transfusion have been shown to optimize survival, mitigate the acute coagulopathy of trauma, and restore the endothelial glycocalyx. There are a myriad of plasma formulations available worldwide, including fresh frozen plasma, thawed plasma, liquid plasma, plasma frozen within 24 h, and lyophilized plasma (LP). Significant equipoise exists in the literature regarding the optimal plasma formulation...
November 2016: Shock
https://www.readbyqxmd.com/read/26323858/helicopter-in-flight-resuscitation-with-freeze-dried-plasma-of-a-patient-with-a-high-velocity-gunshot-wound-to-the-neck-in-afghanistan-a-case-report
#7
Mikael Gellerfors, Joacim Linde, Dan Gryth
Massive hemorrhage with coagulopathy is one of the leading causes of preventable death in the battlefield. The development of freeze-dried plasma (FDP) allows for early treatment with coagulation-optimizing resuscitation fluid in the prehospital setting. This report describes the first prehospital use of FDP in a patient with carotid artery injury due to a high-velocity gunshot wound (HVGSW) to the neck. It also describes in-flight constitution and administration of FDP in a Medevac Helicopter. Early administration of FDP may contribute to hemodynamic stabilization and reduction in trauma-induced coagulopathy and acidosis...
October 2015: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/26091311/effect-of-ascorbic-acid-concentrations-on-hemodynamics-and-inflammation-following-lyophilized-plasma-transfusion
#8
Sean P McCully, David T Martin, Mackenzie R Cook, Nicole T Gordon, Belinda H McCully, Tim H Lee, Rondi K Dean, Elizabeth A Rick, Alexis M Moren, Kelly A Fair, Vicente J Undurraga, Kathrine M Watson, Nathan W Anderson, Martin A Schreiber
BACKGROUND: Compared with lyophilized plasma (LP) buffered with other acids, LP with ascorbic acid (AA) attenuates systemic inflammation and DNA damage in a combat relevant polytrauma swine model. We hypothesize that increasing concentrations of AA in transfused LP will be safe, will be hemodynamically well tolerated, and will attenuate systemic inflammation following polytraumatic injury and hemorrhage in swine. METHODS: This prospective, randomized, blinded study involved 52 female swine...
July 2015: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/26002261/coagulation-function-of-stored-whole-blood-is-preserved-for-14-days-in-austere-conditions-a-rotem-feasibility-study-during-a-norwegian-antipiracy-mission-and-comparison-to-equal-ratio-reconstituted-blood
#9
Geir Strandenes, Ivar Austlid, Torunn O Apelseth, Tor A Hervig, Jan Sommerfelt-Pettersen, Maryanne C Herzig, Andrew P Cap, Heather F Pidcoke, Einar K Kristoffersen
BACKGROUND: Formulation of a medical preparedness plan for treating severely bleeding casualties during naval deployment is a significant challenge because of territory covered during most missions. The aim of this study was to evaluate the concept of "walking blood bank" as a supportable plan for supplying safe blood and blood products. METHODS: In 2013, the Royal Norwegian Navy conducted antipiracy operations from a frigate, beginning in the Gulf of Aden and ending in the Indian Ocean...
June 2015: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/26002260/freeze-dried-plasma-and-fresh-red-blood-cells-for-civilian-prehospital-hemorrhagic-shock-resuscitation
#10
Geir A Sunde, Bjarne Vikenes, Geir Strandenes, Kjell-Christian Flo, Tor A Hervig, Einar K Kristoffersen, Jon-Kenneth Heltne
BACKGROUND: The last decade of military trauma care has emphasized the role of blood products in the resuscitation of hemorrhaging patients. Damage-control resuscitation advocates decreased crystalloid use and reintroduces blood components as primary resuscitative fluids. The systematic use of blood products have been described in military settings, but reports describing the use of freeze dried plasma (FDP) or red blood cells (RBCs) in civilian prehospital care are few. We describe our preliminary results after implementing RBCs and FDP into our Helicopter Emergency Medical Service (HEMS)...
June 2015: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/25757106/reconstitution-fluid-type-does-not-affect-pulmonary-inflammation-or-dna-damage-following-infusion-of-lyophilized-plasma
#11
Sean P McCully, Tim H Lee, Belinda H McCully, Claire L Sands, Elizabeth A Rick, Rondi K Dean, Nathan W Anderson, David A Hampton, Scott G Louis, Jerome A Differding, Martin A Schreiber
BACKGROUND: Dysfunctional inflammation following traumatic hemorrhage can lead to multiple-organ failure and death. In our polytrauma swine model, lyophilized plasma (LP) reconstituted with sterile water and ascorbic acid suppressed systemic inflammation and attenuated DNA damage. However, it remains unknown whether the inflammatory response is affected by the type of fluid used to reconstitute LP. We hypothesized that common resuscitation fluids such as normal saline (LP-NS), lactated Ringer's solution (LP-LR), Hextend (LP-HX), or sterile water (LP-SW) would yield similar inflammation profiles and DNA damage following LP reconstitution and transfusion...
February 2015: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/25297052/a-novel-nanobiotherapeutic-poly-hemoglobin-superoxide-dismutase-catalase-carbonic-anhydrase-with-no-cardiac-toxicity-for-the-resuscitation-of-a-rat-model-with-90-minutes-of-sustained-severe-hemorrhagic-shock-with-loss-of-2-3-blood-volume
#12
Yuzhu Bian, Thomas Ming Swi Chang
We crosslink hemoglobin (Hb), superoxide dismutase (SOD), catalase (CAT), and carbonic anhydrase (CA) to form a soluble polyHb-SOD-CAT-CA nanobiotechnological complex. The obtained product is a soluble complex with three enhanced red blood cell (RBC) functions and without blood group antigens. In the present study, 2/3 of blood volume was removed to result in 90-min hemorrhagic shock at mean arterial blood pressure (MAP) of 30 mmHg. This was followed by the reinfusion of different resuscitation fluids, then followed for another 60 min...
February 2015: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/25284434/-haemovigilance-and-blood-safety-in-overseas-military
#13
REVIEW
A Sailliol, S Plang, C Martinaud, T Pouget, S Vedy, B Clavier, V Cellarier, C Roche, C Civadier, S Ausset
The French military blood institute (FMBI) is the only military blood supplier in France. FMBI operates independently and autonomously under the Ministry of Defense's supervision, and accordingly, to the French, European and NATO technical and safety guidelines. FMBI is in charge of the collection, preparation and distribution of blood products to supply transfusion support to armed forces, especially during overseas operations. In overseas military, a primary physician is responsible for haemovigilance in permanent relation with an expert in the FMBI to manage any adverse reaction...
November 2014: Transfusion Clinique et Biologique: Journal de la Société Française de Transfusion Sanguine
https://www.readbyqxmd.com/read/25187229/nanosuspension-development-of-scutellarein-as-an-active-and-rapid-orally-absorbed-precursor-of-its-bcs-class-iv-glycoside-scutellarin
#14
Xiao Yang, Xiaoqing Miao, Fangrui Cao, Shang Li, Nana Ai, Qi Chang, Simon M Y Lee, Ying Zheng
This work addressed solubility and membrane permeability problems of Biopharmaceutics Classification System (BCS) Class IV glycoside scutellarin (SG) by developing a nanosuspension of its aglycone scutellarein (S) as a precursor. An S nanosuspension containing poloxamer 188 was prepared using antisolvent precipitation where hydroxypropyl-β-cyclodextrin was utilized as a lyophilizing protectant. Particle size and polydispersity index after redispersion were 342.6 ± 18.2 and 0.32 ± 0.06 nm, respectively. The dissolution rate of the S nanosuspension was superior compared with the physical mixture...
November 2014: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/24458032/comparison-of-the-hemostatic-efficacy-of-low-volume-lyophilized-plasma-reconstituted-using-sterile-water-lactated-ringer-s-normal-saline-and-hextend-solutions
#15
COMPARATIVE STUDY
Tim H Lee, Sean P McCully, Belinda H McCully, Claire Sands, David A Hampton, Scott G Louis, Beth Rick, Nathan Anderson, Jerome Differding, Martin A Schreiber
BACKGROUND: Low-volume ascorbic acid-buffered reconstituted lyophilized plasma (LP) provides logistic advantages, reduces the risks for large-volume resuscitation, modulates inflammation, and is equally effective for hemostatic resuscitation as full-volume LP. We compared the physiologic effects of resuscitation using LP reconstituted with sterile water (LP-SW), lactated Ringer's solution (LP-LR), normal saline (LP-NS), and Hextend (LP-Hx). METHODS: Plasma was collected from swine, lyophilized, and then reconstituted into four test solutions: LP-SW, LP-LR, LP-NS, or LP-Hx...
February 2014: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/24089000/freeze-dried-plasma-at-the-point-of-injury-from-concept-to-doctrine
#16
REVIEW
Elon Glassberg, Roy Nadler, Sami Gendler, Amir Abramovich, Philip C Spinella, Robert T Gerhardt, John B Holcomb, Yitshak Kreiss
While early plasma transfusion for the treatment of patients with ongoing major hemorrhage is widely accepted as part of the standard of care in the hospital setting, logistic constraints have limited its use in the out-of-hospital setting. Freeze-dried plasma (FDP), which can be stored at ambient temperatures, enables early treatment in the out-of-hospital setting. Point-of-injury plasma transfusion entails several significant advantages over currently used resuscitation fluids, including the avoidance of dilutional coagulopathy, by minimizing the need for crystalloid infusion, beneficial effects on endothelial function, physiological pH level, and better maintenance of intravascular volume compared with crystalloid-based solutions...
December 2013: Shock
https://www.readbyqxmd.com/read/23718572/transfusion-and-hematologic-variables-after-fibrinogen-or-platelet-transfusion-in-valve-replacement-surgery-preliminary-data-of-purified-lyophilized-human-fibrinogen-concentrate-versus-conventional-transfusion
#17
RANDOMIZED CONTROLLED TRIAL
Kenichi A Tanaka, Katherine Egan, Fania Szlam, Satoru Ogawa, John D Roback, Gautam Sreeram, Robert A Guyton, Edward P Chen
BACKGROUND: Platelet (PLT) and plasma transfusion remain the mainstay hemostatic therapy for perioperative bleeding. Several studies have indicated that acquired fibrinogen (FIB) deficiency can be the primary cause of bleeding after cardiac surgery. The aim of this study was to compare hematologic and transfusion profiles between the first-line FIB replacement and PLT transfusion in post-cardiac surgical bleeding. STUDY DESIGN AND METHODS: In this prospective, randomized, open-label study, 20 adult patients who underwent valve replacement or repair and fulfilled preset visual bleeding scale were randomized to 4 g of FIB or 1 unit of apheresis PLTs...
January 2014: Transfusion
https://www.readbyqxmd.com/read/23581390/quality-of-freeze-dried-lyophilized-quarantined-single-donor-plasma
#18
Jürgen Bux, Dieter Dickhörner, Edgar Scheel
BACKGROUND: Transfusion of plasma is a basic treatment for complex coagulopathies as well as in major blood loss. Early transfusion of plasma after trauma with major hemorrhage has been recommended by retrospective studies. However, the use of plasma is often hampered by the need to maintain a cold chain and the time needed for thawing fresh-frozen plasma (FFP). With freeze-dried (lyophilized) plasma (FDP) both difficulties can be avoided. Here, we describe the production, quality characteristics, and our experiences with FDP...
December 2013: Transfusion
https://www.readbyqxmd.com/read/23301977/the-use-of-lyophilized-plasma-in-a-severe-multi-injury-pig-model
#19
Tim H Lee, Philbert Y Van, Nicholas J Spoerke, Gregory J Hamilton, S David Cho, Kate Watson, Jerome Differding, Martin A Schreiber
BACKGROUND: Shock and severe tissue injury lead to an endogenous coagulopathy mediated by activation of Protein C and hyperfibrinolysis known as acute traumatic coagulopathy. Together, hemodilution, acidosis, inflammation, and hypothermia result in a global trauma-induced coagulopathy. Coagulopathy in trauma is associated with mortality. Early and effective hemostatic resuscitation is critical in restoring perfusion, correcting coagulopathy, and saving lives in exsanguinating trauma. Lyophilized plasma (LP) provides a logistically superior alternative to fresh frozen plasma (FFP)...
January 2013: Transfusion
https://www.readbyqxmd.com/read/23301975/the-evolving-role-of-lyophilized-plasma-in-remote-damage-control-resuscitation-in-the-french-armed-forces-health-service
#20
Anne Sailliol, Christophe Martinaud, Andrew P Cap, Corinne Civadier, Benoit Clavier, Anne-Virginie Deshayes, Anne-Christine Mendes, Thomas Pouget, Nicolas Demazeau, Marine Chueca, François-Régis Martelet, Sylvain Ausset
Freeze-dried plasma was developed by the US Army for the resuscitation of combat casualties during World War II. The French Military Blood Institute began producing French lyophilized plasma (FLYP) in 1949, in accordance with French blood product guidelines. Since 2010, a photochemical pathogen inactivation process has been implemented to reduce the remaining transfusion-related infectious risk. All quality controls for this procedure verify that the hemostatic properties of FLYP are conserved. FLYP is compatible with all blood types, can be stored at room temperature for 2 years, and its reconstitution requires less than 6 minutes...
January 2013: Transfusion
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