keyword
https://read.qxmd.com/read/38504714/mechanisms-of-torsades-de-pointes-an-update
#1
REVIEW
Yukiomi Tsuji, Masatoshi Yamazaki, Masafumi Shimojo, Satoshi Yanagisawa, Yasuya Inden, Toyoaki Murohara
Torsades de Pointes (TdP) refers to a polymorphic ventricular tachycardia (VT) with undulating QRS axis that occurs in long QT syndrome (LQTS), although the term has been used to describe polymorphic ventricular tachyarrhythmias in which QT intervals are not prolonged, such as short-coupled variant of TdP currently known as short-coupled ventricular fibrillation (VF) and Brugada syndrome. Extensive works on LQTS-related TdP over more than 50 years since it was first recognized by Dessertennes who coined the French term meaning "twisting of the points", have led to current understanding of the electrophysiological mechanism that TdP is initiated by triggered activity due to early afterdepolarization (EAD) and maintained by reentry within a substrate of inhomogeneous repolarization...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38477371/endocardial-repolarization-dispersion-in-brs-a-novel-automatic-algorithm-for-mapping-activation-recovery-interval
#2
JOURNAL ARTICLE
Sara Latrofa, Valentina Hartwig, Lorenzo Bachi, Pasquale Notarstefano, Silvia Garibaldi, Luca Panchetti, Martina Nesti, Paolo Seghetti, Umberto Startari, Gianluca Mirizzi, Maria Sole Morelli, Martina Modena, Andrea Mazzanti, Michele Emdin, Alberto Giannoni, Andrea Rossi
INTRODUCTION: Repolarization dispersion in the right ventricular outflow tract (RVOT) contributes to the type-1 electrocardiographic (ECG) phenotype of Brugada syndrome (BrS), while data on the significance and feasibility of mapping repolarization dispersion in BrS patients are scarce. Moreover, the role of endocardial repolarization dispersion in BrS is poorly investigated. We aimed to assess endocardial repolarization patterns through an automated calculation of activation recovery interval (ARI) estimated on unipolar electrograms (UEGs) in spontaneous type-1 BrS patients and controls; we also investigated the relation between ARI and right ventricle activation time (RVAT), and T-wave peak-to-end interval (Tpe) in BrS patients...
March 13, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38464963/whole-heart-computational-modelling-provides-further-mechanistic-insights-into-st-elevation-in-brugada-syndrome
#3
JOURNAL ARTICLE
Eike M Wülfers, Robin Moss, Heiko Lehrmann, Thomas Arentz, Dirk Westermann, Gunnar Seemann, Katja E Odening, Johannes Steinfurt
BACKGROUND: Brugada syndrome (BrS) is characterized by dynamic ST-elevations in right precordial leads and increased risk of ventricular fibrillation and sudden cardiac death. As the mechanism underlying ST-elevation and malignant arrhythmias is controversial computational modeling can aid in exploring the disease mechanism. Thus we aim to test the main competing hypotheses ('delayed depolarization' vs. 'early repolarization') of BrS in a whole-heart computational model. METHODS: In a 3D whole-heart computational model, delayed epicardial RVOT activation with local conduction delay was simulated by reducing conductivity in the epicardial RVOT...
April 2024: IJC Heart & Vasculature
https://read.qxmd.com/read/38412448/prevalence-and-clinical-significance-of-electrocardiographic-complete-right-bundle-branch-block-in-young-individuals
#4
JOURNAL ARTICLE
H MacLachlan, A Antonakaki, R Bhatia, S Fyazz, N Chatrath, E Androulakis, S Marawaha, J Basu, C Miles, H Dhutia, A Zaidi, N Chandra, N Sheikh, S Gati, A Malhotra, G Finocchiaro, S Sharma, M Papadakis
BACKGROUND AND AIMS: There is limited information on the clinical significance of complete right bundle branch block (CRBBB) in young individuals. The aim of this study was to determine the prevalence and significance of CRBBB in a large cohort of young individuals aged 14-35 years old. METHODS: From 2008 to 2018, 104,369 consecutive individuals underwent a cardiovascular assessment with a health questionnaire, electrocardiogram, clinical consultation, and selective echocardiography...
February 27, 2024: European Journal of Preventive Cardiology
https://read.qxmd.com/read/38404980/the-loss-of-function-variant-p-m764r-in-the-cardiac-sodium-channel-na-v-1-5-is-associated-with-ventricular-arrhythmias-and-sudden-cardiac-death-in-a-family-without-overt-brugada-syndrome
#5
Kirstine Calloe, Morten Krogh Christiansen, Finn Lund Henriksen, Henrik Kjærulf Jensen
No abstract text is available yet for this article.
February 2024: HeartRhythm Case Reports
https://read.qxmd.com/read/38348526/brugada-syndrome-in-iran-insights-from-a-12-year-longitudinal-study
#6
JOURNAL ARTICLE
Majid Haghjoo, Amir Askarinejad, Shabnam Madadi, Amirfarjam Fazelifar, Farzad Kamali, Abolfath Alizadeh-Diz, Zahra Emkanjoo
BACKGROUND: Brugada syndrome (BrS) is characterized by ST-segment elevation in the right precordial leads, which is not explained by ischemia, electrolyte disturbances, or obvious structural heart disease. AIM: In present study, we aim to evaluate presentation, long-term outcome, genetic findings, and therapeutic interventions in patients with BrS. METHODS: Between September 2001 and June 2022, all consecutive patients with diagnosis of BrS were enrolled in the present study...
February 13, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38337505/importance-of-comprehensive-assessment-in-brugada-syndrome-reply-to-kataoka-n-imamura-t-how-to-diagnose-and-risk-stratify-brugada-syndrome-comment-on-matusik-et-al-twelve-lead-ecg-holter-monitoring-parameters-and-genetic-testing-in-brugada-syndrome-insights
#7
JOURNAL ARTICLE
Paweł T Matusik, Piotr Bijak, Magdalena Kaźnica-Wiatr, Marek Karpiński, Patrycja S Matusik, Andrzej Maziarz, Piotr Podolec, Jacek Lelakowski
We would like to thank Dr. Imamura for their interest in our study and their valuable comments on diagnostics and risk stratification in Brugada syndrome (BrS) [...].
January 31, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38333823/echo-state-networks-for-the-recognition-of-type-1-brugada-syndrome-from-conventional-12-lead-ecg
#8
JOURNAL ARTICLE
Federico Vozzi, Luca Pedrelli, Giovanna Maria Dimitri, Alessio Micheli, Elisa Persiani, Marcello Piacenti, Andrea Rossi, Gianluca Solarino, Paolo Pieragnoli, Luca Checchi, Giulio Zucchelli, Lorenzo Mazzocchetti, Raffaele De Lucia, Martina Nesti, Pasquale Notarstefano, Maria Aurora Morales
Artificial Intelligence (AI) applications and Machine Learning (ML) methods have gained much attention in recent years for their ability to automatically detect patterns in data without being explicitly taught rules. Specific features characterise the ECGs of patients with Brugada Syndrome (BrS); however, there is still ambiguity regarding the correct diagnosis of BrS and its differentiation from other pathologies. This work presents an application of Echo State Networks (ESN) in the Recurrent Neural Networks (RNN) class for diagnosing BrS from the ECG time series...
February 15, 2024: Heliyon
https://read.qxmd.com/read/38333419/non-invasive-cardiac-activation-mapping-and-identification-of-severity-of-epicardial-substrate-in-brugada-syndrome-a-case-report
#9
Saverio Iacopino, Paolo Sorrenti, Giuseppe Campagna, Gennaro Fabiano, Emmanuel Fabiano, Jacopo Colella
INTRODUCTION: It has recently been shown that electrocardiographic imaging (ECGi) can be employed in individuals undergoing an ajmaline test who have Brugada Syndrome (BrS), to evaluate the extent of substrate-involved arrhythmia in the right ventricular overflow tract (RVOT). For the first time, we stratify the risk of sudden cardiac death (SCD) in BrS during ajmaline testing using the dST-Tiso interval (a robust predictor of the inducibility of ventricular arrhythmias (VAs) in the presence of drug-induced BrS type-1 pattern) in combination with ECGi technology...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38330292/severe-hypothyroidism-as-a-trigger-for-brugada-type-ecg-abnormalities-a-case-report-and-literature-review
#10
REVIEW
Fabio Bioletto, Daniela Cuboni, Emanuele Varaldo, Chiara Bona, Alessandro Maria Berton, Mauro Maccario, Nunzia Prencipe
Brugada syndrome (BrS) is an inherited disorder that can cause ventricular fibrillation and sudden cardiac death in individuals with otherwise structurally normal hearts. Several provoking factors are known to potentially unmask or exacerbate a typical Brugada ECG pattern in predisposed subjects. Hypothyroidism has been suggested as one of these triggers, but the exact mechanisms underlying this relationship remain poorly understood. Moreover, the severity of thyroid dysfunction beyond which a Brugada-type ECG alteration might be triggered is still unclear...
February 8, 2024: Archives of Endocrinology and Metabolism
https://read.qxmd.com/read/38322613/intracardiac-electrophysiology-to-characterize-susceptibility-to-ventricular-arrhythmias-in-murine-models
#11
JOURNAL ARTICLE
Marine C Ferrand, Gauthier Giordano, Nathalie Mougenot, Pierre-Léo Laporte, Nicolas Vignier, Arnaud Leclerc, Vincent Algalarrondo, Fabrice Extramiana, Flavien Charpentier, Nathalie Neyroud
Introduction: Sudden cardiac death (SCD) and ventricular fibrillation are rare but severe complications of many cardiovascular diseases and represent a major health issue worldwide. Although the primary causes are often acute or chronic coronary diseases, genetic conditions, such as inherited channelopathies or non-ischemic cardiomyopathies are leading causes of SCD among the young. However, relevant experimental models to study the underlying mechanisms of arrhythmias and develop new therapies are still needed...
2024: Frontiers in Physiology
https://read.qxmd.com/read/38313980/pilsicainide-toxicity-induced-brugada-like-st-segment-elevation-and-increased-pacing-voltage-threshold
#12
Kosuke Hirose, Yoh Arita, Nobuyuki Ogasawara
Pilsicainide is a class Ic antiarrhythmic agent that exhibits fully selective sodium channel blockade. In Japan, it is one of the most prescribed medicines for rhythm control in atrial fibrillation. Pilsicainide is mainly excreted by the kidney. Therefore, the plasma concentration of pilsicainide is likely to be increased in patients with renal insufficiency. In this case report, a 90-year-old woman presented with generalized fatigue and loss of appetite. Her ECG showed marked bradycardia and coved-type ST-segment elevation similar to that of the Brugada type 1 pattern...
January 2024: Curēus
https://read.qxmd.com/read/38309590/-inherited-cardiovascular-disease-mindset-can-identify-concealed-inherited-conditions-at-cardio-oncology-evaluation-an-opportunistic-screening
#13
JOURNAL ARTICLE
Rebeca Lorca, María Fernández, Pablo Avanzas, Isaac Pascual, Rut Álvarez-Velasco, Iria Silva, Luis Gutiérrez, Juan Gómez, María Muñiz, Carlos Álvarez, Emilio Esteban, Teresa López-Fernández
INTRODUCTION: Baseline cardiovascular (CV) risk stratification is recommended in all cancer patients. Integrating all clinical information (personal/family history, ECG and echocardiogram) can properly identify high-risk patients. We aimed to evaluate the concealed inherited CV conditions detected in mandatory CV screening performed at a Cardio-Oncology Unit. METHODS: retrospective study of all consecutive cancer patients referred to the Cardio-Oncology Unit for CV evaluation (2020-2023)...
February 1, 2024: International Journal of Cardiology
https://read.qxmd.com/read/38299604/type-i-brugada-pattern-in-a-febrile-patient-following-covid-19-vaccination-booster
#14
JOURNAL ARTICLE
Robert Cacdac, Anthony Lim, Jonathan Ghazaleh, Shiva Salmasi, Sayna Poursadrolah, Monica Jordan, Andrew Rubin
There have been studies published regarding the association between developing Brugada syndrome after an acute COVID-19 infection. In this case, we present a patient who presented with a syncopal episode and subsequently found to have Type I Brugada pattern on electrocardiogram. The patient underwent placement of a single chamber defibrillator. Genetic analysis demonstrated SCN5A variant which is associated with cardiac conditions including Brugada syndrome.
2024: Journal of Investigative Medicine High Impact Case Reports
https://read.qxmd.com/read/38246906/a-machine-learning-approach-to-differentiate-wide-qrs-tachycardia-distinguishing-ventricular-tachycardia-from-supraventricular-tachycardia
#15
JOURNAL ARTICLE
Zhen-Zhen Li, Wei Zhao, YangMing Mao, Dan Bo, QiuShi Chen, Pipin Kojodjojo, FengXiang Zhang
BACKGROUND: Differential diagnosis of wide QRS tachycardia (WQCT) has been a challenging issue. Published algorithms to distinguish ventricular tachycardia (VT) and supraventricular tachycardia (SVT) have limited diagnostic capabilities. METHODS: A total of 278 patients with WQCT from January 2010 to March 2022 were enrolled. The electrophysiological study confirmed SVT in 154 patients and VT in 65 ones. Two hundred nineteen WQCT 12-lead ECGs were randomly divided into development cohort (n = 165) and testing cohort (n = 54) data sets...
January 22, 2024: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://read.qxmd.com/read/38242222/long-term-clinical-outcomes-of-patients-with-drug-induced-type-1-brugada-electrocardiographic-pattern-a-nationwide-cohort-registry-study
#16
JOURNAL ARTICLE
Vincenzo Russo, Alfredo Caturano, Federico Migliore, Federico Guerra, Pietro Francia, Martina Nesti, Giulio Conte, Alessandro Paoletti Perini, Giuseppe Mascia, Stefano Albani, Procolo Marchese, Vincenzo Ezio Santobuono, Gregory Dendramis, Andrea Rossi, Emilio Attena, Andrea Ottonelli Ghidini, Luigi Sciarra, Zefferino Palamà, Enrico Baldi, Emanuele Romeo, Antonio D'Onofrio, Gerardo Nigro
BACKGROUND: There are limited real-world data about the extended prognosis of patients with drug-induced type 1 Brugada electrocardiogram (ECG). OBJECTIVE: We assessed the clinical outcomes and predictors of life-threatening arrhythmias in patients with drug-induced type 1 Brugada ECG. MATERIALS AND METHODS: This multicenter retrospective study, conducted at 21 Italian and Swiss hospitals from July 1997 to May 2021, included consecutive patients with drug-induced type 1 ECG...
January 17, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://read.qxmd.com/read/38214908/mannitol-and-hyponatremia-regulate-cardiac-ventricular-conduction-in-the-context-of-sodium-channel-loss-of-function
#17
JOURNAL ARTICLE
Grace A Blair, Xiaobo Wu, Chandra Bain, Mark Warren, Gregory S Hoeker, Steven Poelzing
BACKGROUND: Scn5a heterozygous null (Scn5a+/- ) mice have historically been used to investigate arrhythmogenic mechanisms of diseases such as Brugada Syndrome and Lev's disease. Previously, we demonstrated that reducing ephaptic coupling (EpC) in ex vivo hearts exacerbates pharmacological Nav 1.5 loss of function (LOF). Whether this effect is consistent in a genetic Nav 1.5 LOF model is yet to be determined. We hypothesized that loss of EpC would result in greater reduction in conduction velocity (CV) for the Scn5a+/- mouse relative to wild type (WT)...
January 12, 2024: American Journal of Physiology. Heart and Circulatory Physiology
https://read.qxmd.com/read/38211772/prevalence-of-brugada-electrocardiographic-pattern-in-adult-population-a-community-based-study-from-kerala-south-india
#18
JOURNAL ARTICLE
Mangalath Narayanan Krishnan, Zachariah Geevar, Krishnan Nair Venugopal, Padinhare Purayil Mohanan, Sivadasanpillai Harikrishnan, Ganapathi Sanjay, Kavumpurathu Raman Thankappan
There is no data for Brugada electrocardiographic pattern (BrEP) from India. In a cross-sectional study of men and women between the ages 20-79 years, electrocardiograms were analyzed following the 2002 consensus. The overall prevalence of BrEP was 1.06 % (95 % CI 0.76, 1.35). There were two cases type I (0.04 %; 95 % CI 0.01, 0.06) and forty-seven type II/III (1.01 %; 95 % CI 1.02, 1.35); the pattern was markedly higher in men. In this study, BrEP was slightly less prevalent compared to South Asia but more than in the west...
January 9, 2024: Indian Heart Journal
https://read.qxmd.com/read/38137616/how-to-diagnose-and-risk-stratify-brugada-syndrome-comment-on-matusik-et-al-twelve-lead-ecg-holter-monitoring-parameters-and-genetic-testing-in-brugada-syndrome-insights-from-analysis-of-multigenerational-family-with-a-history-of-sudden-cardiac-arrest-during
#19
JOURNAL ARTICLE
Naoya Kataoka, Teruhiko Imamura
Brugada syndrome stands as an arrhythmogenic disorder bearing the grim specter of heightened susceptibility to syncopal episodes and sudden cardiac demise [...].
December 7, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/38095085/the-role-of-mapre2-and-microtubules-in-maintaining-normal-ventricular-conduction
#20
JOURNAL ARTICLE
David Y Chiang, Arie O Verkerk, Rachelle Victorio, Boris I Shneyer, Babet van der Vaart, Mariam Jouni, Nakul Narendran, Ashmita Kc, James R Sampognaro, Franki Vetrano-Olsen, John S Oh, Eva Buys, Berend de Jonge, Disheet A Shah, Tuomas Kiviniemi, Paul W Burridge, Connie R Bezzina, Anna Akhmanova, Calum A MacRae
BACKGROUND: The Brugada syndrome is associated with loss-of-function SCN5A variants, yet these account for only ≈20% of cases. A recent genome-wide association study identified a novel locus within MAPRE2 , which encodes EB (microtubule end-binding protein) 2, implicating microtubule involvement in the Brugada syndrome. METHODS: A mapre2 knockout zebra fish model was generated using CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeat-associated 9) and validated by Western blot...
December 14, 2023: Circulation Research
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