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https://www.readbyqxmd.com/read/29161787/cancer-control-algorithm
#1
Sunil Kumar Kashyap, Birendra Kumar Sharma, Amitabh Banerjee
Curing cancer by controlling the growth of the cancer cell is the objective of this paper. The growth of the cancer cell is analysed by the optimization programming. The algorithm is proposed for minimizing the rate of growth of the cancer cell. Hence the chaotic cancer became structured for the further research. This is an extended work of Warburg [1], where he defined the centre of the cancer cell, known by Warburg effect, but here we control the increasing radius of the cancer circle by the proposed Cancer Control Algorithm...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161786/oral-submucous-fibrosis-an-etiological-dilemma
#2
Aanchal Sharma, Rajesh Kumar, Navdeep Johar, Husain Sabir
Oral Submucous Fibrosis (OSF), is a well-recognized, oral potentially malignant disorder predominantly affecting the South- Asian countries. OSF causes unique generalized fibrosis of the submucosal oral soft tissues, resulting in marked rigidity of the oral mucosa leading to progressive inability to open the mouth, rigidity of lips and difficulty in protruding the tongue. In this review we have discussed the multifactorial etiology of this potentially malignant disorder, including Chillies, Nutritional Deficiencies, Inducible nitric oxide synthsis (iNOS), genetic and immunological predisposition; and most importantly the role of areca nut and the effect of copper content in it...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161782/cancer-cell-controller
#3
Sunil Kumar Kashyap, Vikas Kumar Jain, Swati Jain, Ashutosh Pandey
Cancer is the disease which exists when the cell is uncontrolled. This paper presents a controller for the same. The cancer cell is reviewed via algebraic structures.
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161780/assessment-of-relationship-of-abo-blood-groups-among-tobacco-induced-oral-cancer-patients-of-kanpur-population-uttar-pradesh
#4
Gayathri Ramesh, Anuradha Katiyar, Amrita Raj, Amit Kumar, Ramesh Nagarajappa, Amit Pandey
Background: The possibility of association between ABO blood groups and malignancy was first discussed by Anderson DE & Haas C. The association between blood group and oral cancer is least explored and hence this study was undertaken to evaluate relationship of ABO blood groups with an increased risk for oral cancer. Materials and method: The present study was conducted at various cancer hospitals in Kanpur. The study samples comprised 100 oral cancer patients and 50 controls with tobacco chewing habit...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161779/micronuclei-assay-in-exfoliated-buccal-cells-of-radiation-treated-oral-cancer-patients
#5
Gayathri Ramesh, Smriti Chaubey, Amrita Raj, Ravi Kumar Seth, Anuradha Katiyar, Amit Kumar
BACKGROUND: Micronuclei are suitable internal dosimeters for revealing tissue-specific genotoxic damage in individuals exposed to carcinogenic mixtures. Evaluation of radiation-induced cellular changes to predict radiosensitivity has invested many investigators since such changes were first found in biopsy material. AIM: The aim of the present study was to assess the relationship of with histopathological grade and number of radiation therapy sittings with the frequency of micronuclei and nuclear anomalies among oral cancer patients...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161776/awareness-on-cytology-procedure-in-oral-cancer-detection-among-undergraduates-an-institutional-study
#6
Gayathri Ramesh, Rajeev Pathak, Sunita Pathak, Amrita Raj, Amit Kumar, Anuradha Katiyar
Background: The screening and the early detection of the premalignant and malignant lesions are the only means for controlling the oral cancer which is known to be one of the leading causes for mortality worldwide. Oral exfoliative cytology though not a substitute for biopsy can be a powerful tool for its early detection. Dental Surgeons can play a great role in this direction. Aims and Objectives: The present study was undertaken to assess the self-reported knowledge and attitude regarding the early detection of oral cancer and exfoliative cytology among the undergraduates of Rama Dental College, Kanpur...
November 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/29161618/bayesian-synthesis-for-simulation-based-generation-of-probability-of-detection-pod-curves
#7
Mohamed Subair Syed Akbar Ali, Anish Kumar, Purnachandra B Rao, Jayakumar Tammana, Krishnan Balasubramaniam, Prabhu Rajagopal
This paper examines the feasibility of using Bayesian synthesis to reduce the number of experimental cases and trials required for generation of probability of detection (PoD) curves. A Bayesian framework is developed for the data-level combination of experimental and simulated datasets, in the context of the inspection of back-wall breaking notches in metallic samples by bulk ultrasonic shear waves. PoD curves generated using the proposed approach, where results from a reduced number of experimental defect cases and trials are used in combination with simulated datasets, are shown to compare well with those from the conventional approach using a large number of experiments...
November 4, 2017: Ultrasonics
https://www.readbyqxmd.com/read/29161573/decentralized-biorefinery-for-lignocellulosic-biomass-integrating-anaerobic-digestion-with-thermochemical-conversion
#8
Chayanon Sawatdeenarunat, Hyungseok Nam, Sushil Adhikari, Shihwu Sung, Samir Kumar Khanal
Anaerobic digestion (AD) of lignocellulosic biomass i.e. Napier grass (Pennisetum purpureum), was investigated via a series of batch and bench-scale experiments. Two semi-continuous bench-scale horizontal bioreactors were operated in parallel for nearly 300 days, and the reactors were able to handle the organic loading rate (OLR) up to 6 kg volatile solids (VS)/m(3)-d, which was among the highest OLR reported in the literature for lignocellulosic biomass. Hemicellulose was the main structural carbohydrate of lignocellulosic biomass per unit respective mass (dry weight) basis contributing to methane production...
November 9, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29161423/partial-bisulfite-conversion-for-unique-template-sequencing
#9
Vijay Kumar, Julie Rosenbaum, Zihua Wang, Talitha Forcier, Michael Ronemus, Michael Wigler, Dan Levy
We introduce a new protocol, mutational sequencing or muSeq, which uses sodium bisulfite to randomly deaminate unmethylated cytosines at a fixed and tunable rate. The muSeq protocol marks each initial template molecule with a unique mutation signature that is present in every copy of the template, and in every fragmented copy of a copy. In the sequenced read data, this signature is observed as a unique pattern of C-to-T or G-to-A nucleotide conversions. Clustering reads with the same conversion pattern enables accurate count and long-range assembly of initial template molecules from short-read sequence data...
November 17, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/29161321/association-mapping-unveils-favorable-alleles-for-grain-iron-and-zinc-concentrations-in-lentil-lens-culinaris-subsp-culinaris
#10
Akanksha Singh, Vinay Sharma, Harsh Kumar Dikshit, Muraleedhar Aski, Harish Kumar, Nepolean Thirunavukkarasu, Basavanagouda S Patil, Shiv Kumar, Ashutosh Sarker
Lentil is a major cool-season grain legume grown in South Asia, West Asia, and North Africa. Populations in developing countries of these regions have micronutrient deficiencies; therefore, breeding programs should focus more on improving the micronutrient content of food. In the present study, a set of 96 diverse germplasm lines were evaluated at three different locations in India to examine the variation in iron (Fe) and zinc (Zn) concentration and identify simple sequence repeat (SSR) markers that associate with the genetic variation...
2017: PloS One
https://www.readbyqxmd.com/read/29161285/hpv-genotypes-co-infections-associated-with-cervical-carcinoma-special-focus-on-phylogenetically-related-and-non-vaccine-targeted-genotypes
#11
Rashmirani Senapati, Bhagyalaxmi Nayak, Shantanu Kumar Kar, Bhagirathi Dwibedi
HPV is the major causative agent for cervical cancer. Study on the risk of cervical cancer associated with different hr-HPV genotypes would be useful for disease management and new vaccine strategy. With limited reports available, the present study aimed to investigate the pattern of HPV genotypes coinfections and risk of cervical carcinoma associated with them in Indian population. 15 HPV genotypes were detected by E6/E7 multiplex nested type-specific PCR in the HPV-positive cervical samples of 172 cervical cancer cases and 174 subjects with normal cytology...
2017: PloS One
https://www.readbyqxmd.com/read/29160909/revisiting-chronic-rejection-following-living-donor-liver-transplantation-in-the-tacrolimus-era-a-single-centre-experience
#12
Narendra Singh Choudhary, Neeraj Saraf, Sanjiv Saigal, Dheeraj Gautam, Amit Rastogi, Sanjay Goja, Prashant Bhangui, Thiagrajan Srinivasan, Sanjay Kumar Yadav, Arvinder Soin
BACKGROUND AND AIMS: Chronic rejection (CR) is an uncommon but important cause of graft dysfunction, leading to graft loss and often requires re-transplantation. This study evaluates the incidence and outcome of patients with CR at a large living donor liver transplant (LDLT) centre. METHODS: Data of patients with CR was retrospectively analyzed in 1232 adult (age >18 years) LDLT on Tacrolimus (mainly) based immunosuppression. Sirolimus/Everolimus (mTOR inhibitors) were added to baseline immunosuppression as rescue therapy in patients with CR...
November 21, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/29160874/biofilm-dispersal-using-nitric-oxide-loaded-nanoparticles-fabricated-by-photo-pisa-influence-of-morphology
#13
Zahra Sadrearhami, Jonathan Yeow, Thuy-Khanh Nguyen, Kitty K K Ho, Naresh Kumar, Cyrille Boyer
Polymeric nanoparticles (NPs) of different morphologies (spheres and worms) were synthesized using a visible light mediated polymerization-induced self-assembly (PISA) approach. Spherical and worm-like NPs were subsequently modified to generate diazeniumdiolate functionalized NPs. Interestingly, the NO release rate and the dispersal of biofilms were found to strongly depend on the NP morphology. NPs with a higher aspect ratio (worms) exhibited a slower NO release rate and greater biofilm dispersal after 1 h of incubation...
November 21, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29160823/in-doped-zno-hexagonal-stepped-nanorods-and-nanodisks-as-potential-scaffold-for-highly-sensitive-phenyl-hydrazine-chemical-sensors
#14
Ahmad Umar, Sang Hoon Kim, Rajesh Kumar, Mohammad S Al-Assiri, A E Al-Salami, Ahmed A Ibrahim, Sotirios Baskoutas
Herein, we report the growth of In-doped ZnO (IZO) nanomaterials, i.e., stepped hexagonal nanorods and nanodisks by the thermal evaporation process using metallic zinc and indium powders in the presence of oxygen. The as-grown IZO nanomaterials were investigated by several techniques in order to examine their morphological, structural, compositional and optical properties. The detailed investigations confirmed that the grown nanomaterials, i.e., nanorods and nanodisks possess well-crystallinity with wurtzite hexagonal phase and grown in high density...
November 21, 2017: Materials
https://www.readbyqxmd.com/read/29160708/photophysics-of-zinc-porphyrin-aggregates-in-dilute-water-ethanol-solutions
#15
Amy L Stevens, Neeraj Kumar Joshi, Matthew F Paige, Ronald Paul Steer
Dimeric and multimeric aggregates of a model metalloporphyrin, zinc tetraphenylporphyrin (ZnTPP), have been produced in a controlled manner by incrementally increasing the water content of dilute aqueous ethanol solutions. Steady state absorption, fluorescence emission and fluorescence excitation spectra have been measured to identify the aggregates present as a function of solvent composition. The dynamics of the excited states of the aggregates produced initially by excitation in the Soret region have been measured by ultrafast fluorescence upconversion techniques...
November 21, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29160705/h-x-x-h-ch3-ch2f-chf2-cf3-and-sih3-bond-activation-by-criegee-intermediates-a-theoretical-perspective
#16
Manoj Kumar, Joseph S Francisco
Using theoretical calculations and Born Oppenheimer molecular dynamics simulations, it is shown here that Criegee intermediate, which is principally produced in the olefin ozonolysis, can activate H-X (X = H, CH3, CH2F, CHF2, CF3, and SiH3) under mild conditions, a reaction that has long been known for transition metals. The zwitter ionic electronic structure of Criegee intermediate makes it an interesting metal-free system for activating enthalpically strong small molecules such as H2, methane, silanes, and boranes...
November 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29160700/tailoring-panchromatic-absorption-and-excited-state-dynamics-of-tetrapyrrole-chromophore-bodipy-rylene-arrays-interplay-of-orbital-mixing-and-configuration-interaction
#17
Amit Kumar Mandal, James R Diers, Dariusz M Niedzwiedzki, Gongfang Hu, Rui Liu, Eric J Alexy, Jonathan S Lindsey, David F Bocian, Dewey Holten
Three sets of tetrapyrrole-chromophore arrays have been examined that exhibit panchromatic absorption across large portions of the near-ultraviolet (NUV) to near-infrared (NIR) spectrum along with favorable excited-state properties for use in solar-energy conversion. The arrays vary the tetrapyrrole (porphyrin, chlorin, bacteriochlorin), chromophore (boron-dipyrrin, perylene, terrylene), and attachment sites (meso-position, β-pyrrole position). In all, seven dyads, one triad, and nine benchmarks in toluene and benzonitrile were studied using steady-state and time-resolved absorption and fluorescence spectroscopy...
November 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29160694/quick-and-selective-dual-mode-detection-of-h2s-gas-by-mobile-app-employing-silver-nanorods-array
#18
Shashank Kumar Gahlaut, Kavita Yadav, Chandrashekhar Sharan, Jitendra Pratap Singh
Hydrogen sulfide (H2S) is a hazardous gas, which not only harms living beings but also poses a significant risk to damage materials placed in culture and art museums, due to its corrosive nature. We demonstrate a novel approach for selective rapid detection of H2S gas using silver nanorods (AgNRs) array on glass substrate at ambient conditions. The arrays were prepared by glancing angle deposition method. The colorimetric and water wetting properties of as-fabricated arrays were found to be highly sensitive towards the sulfurization, in the presence of H2S gas with a minimal concentration in ppm range...
November 21, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29160235/possibile-half-metallicity-and-variable-range-hopping-transport-in-sb-substituted-fe-sub-2-sub-tisn-heusler-alloys
#19
Sayan Chaudhuri, P A Bhobe, Arun Kumar Nigam
Investigation of magnetotransport properties on Fe<sub>2</sub>TiSn<sub>1-x</sub>Sb<sub>x</sub> with 0 ≤ x ≤ 0.6 are presented in this paper. The substitution of Sb in place of Sn decreases the antisite disorder as evident from X ray diffraction patterns as well as from transport properties measurement. The much-disputed upturn in low temperature electrical resistivity of Fe<sub>2</sub>TiSn has been demonstrated to be a result of weak localization induced by antisite disorder...
November 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29160147/impact-of-complete-spinal-cord-injury-on-healing-of-skin-ulcers-in-mouse-models
#20
Suneel Kumar, Martin L Yarmush, Biraja C Dash, Henry C Hsia, Francois Berthiaume
Pressure ulcers (PUs) are common debilitating complications of traumatic spinal cord injury (SCI) and tend to occur in soft tissues around bony prominences. There is, however, little known about the impact of SCI on skin wound healing due to the lack of suitable animal models for studies in controlled experimental settings. Herein we describe a reproducible and clinically relevant mouse model of PUs in the context of complete SCI. Adult male mice (BALB/c) were subjected to thoracic (T9-T10) complete SCI. Immediately after, a skin fold on the back of the mice was lifted and sandwiched between two magnetic discs held in place for 12 hours, thus creating an ischemic area that developed into a PU over the following days...
November 21, 2017: Journal of Neurotrauma
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