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https://www.readbyqxmd.com/read/28938797/revisiting-the-safety-of-aspartame
#1
Arbind Kumar Choudhary, Etheresia Pretorius
Aspartame is a synthetic dipeptide artificial sweetener, frequently used in foods, medications, and beverages, notably carbonated and powdered soft drinks. Since 1981, when aspartame was first approved by the US Food and Drug Administration, researchers have debated both its recommended safe dosage (40 mg/kg/d) and its general safety to organ systems. This review examines papers published between 2000 and 2016 on both the safe dosage and higher-than-recommended dosages and presents a concise synthesis of current trends...
September 1, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28938783/phytochemicals-reduce-aflatoxin-induced-toxicity-in-chicken-embryos
#2
Hsin-Bai Yin, Chi-Hung Chen, Michael J Darre, Ann M Donoghue, Dan J Donoghue, Kumar Venkitanarayanan
Aflatoxins (AF) are toxic metabolites produced by molds, Aspergillus flavus and Aspergillus parasiticus, which frequently contaminate poultry feed ingredients. Ingestion of AF-contaminated feed by chickens leads to deleterious effects, including decreased bird performance and reduced egg production. Moreover, AF residues in fertilized eggs result in huge economic losses by decreasing embryo viability and hatchability. This study investigated the efficacy of 2 generally recognized as safe phytochemicals, namely carvacrol (CR) and trans-cinnamaldehyde (TC), in protecting chicken embryos from AF-induced toxicity...
October 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28938501/risk-of-expectant-management-and-optimal-timing-of-delivery-in-low-risk-term-pregnancies-a-population-based-study
#3
Gustavo Vilchez, Sarah Nazeer, Komal Kumar, Morgan Warren, Jing Dai, Robert J Sokol
No abstract text is available yet for this article.
September 22, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/28938471/low-vitamin-b12-in-pregnancy-is-associated-with-adipose-derived-circulating-mirs-targeting-ppar%C3%AE-and-insulin-resistance
#4
Antonysunil Adaikalakoteswari, Manu Vatish, Mohammad Tauqeer Alam, Sascha Ott, Sudhesh Kumar, Ponnusamy Saravanan
Context: Low vitamin B12 (B12) during pregnancy is associated with higher maternal obesity, insulin resistance(IR) and gestational diabetes(GDM). B12 is a key co-factor in 1-carbon metabolism. Objective: We hypothesize that B12 plays a role in epigenetic regulation by altering circulating miRNAs(miRs) during adipocyte differentiation and results in an adverse metabolic phenotype. Design, settings and main-outcome measure: Human pre-adipocyte cell-line(Chub-S7) were differentiated in various B12 concentrations: Control(500nM), LowB12(0...
September 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938313/a-novel-3-step-method-for-correction-of-type-1-stahl-ear
#5
Mimi R Borrelli, Edward H Davidson, Anand R Kumar
BACKGROUND: Stahl ear, a rare congenital auricular anomaly, occurs when a third crus crosses the scaphoid fossa. Optimal elimination of the third crus and reconstruction the superior crus in type 1 Stahl ear remain undercharacterized. We present a novel 3-step technique to reliably correct a type 1 Stahl ear as a case report. METHODS: A 10-year-old male with bilateral prominent type 1 Stahl ears is presented. An anterior curvilinear helical fold incision and posterior V wedge excision was used for exposure...
September 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28938203/green-synthesis-biological-and-spectroscopic-study-on-the-interaction-of-multi-component-mannich-bases-of-imidazo-2-1-b-benzothiazoles-with-human-serum-albumin
#6
Swetha K Maddili, Leela Prasad Yandrati, Shakuntala Siddam, Vijaya Kumar Kannekanti, Himabindu Gandham
A series of Mannich bases of imidazo[2, l-b]benzothiazoles were prepared through one-pot multi-component reaction in the presence of water as an eco-friendly solvent. All the synthesized compounds were confirmed from IR, (1)HNMR, (13)CNMR, and Mass spectroscopy. Evaluation of in vitro anti-inflammatory and anti-microbial activities of all the synthesized derivatives was further accomplished. These results clearly displayed that compound 6d exhibited outstanding anti-inflammatory activity with a percentage inhibition of 70...
August 19, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28938001/cell-cycle-stage-specific-transcriptional-activation-of-cyclins-mediated-by-hat2-dependant-h4k10-acetylation-of-promoters-in-leishmania-donovani
#7
Udita Chandra, Aarti Yadav, Devanand Kumar, Swati Saha
Chromatin modifications affect several processes. In investigating the Leishmania donovani histone acetyltransferase HAT2, using in vitro biochemical assays and HAT2-heterozygous genomic knockout we found the constitutively nuclear HAT2 acetylated histone H4K10 in vitro and in vivo. HAT2 was essential. HAT2-depleted cells displayed growth and cell cycle defects, and poor survival in host cells. Real time PCR and DNA microarray analyses, as well as rescue experiments, revealed that downregulation of cyclins CYC4 and CYC9 were responsible for S phase and G2/M defects of HAT2-depleted cells respectively...
September 22, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28937970/spectroscopy-and-enhanced-frequency-upconversion-in-nd-3-yb-3-codoped-tpo-glasses-energy-transfer-and-nir-to-visible-upconverter
#8
Mohd Azam, Vineet Kumar Rai, Deepak Kumar Mohanty
TeO2-Pb3O4 (TPO) glasses codoped with Nd(3+) and Yb(3+) ions have been fabricated by conventional melting technique. The absorption, emission and excitation spectra of the samples have been recorded. The optical band gap in both the doped/codoped glasses is found to be ∼3.31 eV. Judd-Ofelt analysis has been carried out by using the absorption spectrum of 0.8 mol% Nd(3+) doped glass to determine the radiative properties viz radiative transition probabilities, branching ratios, radiative lifetimes, quality factor and emission cross sections of some emitting levels for Nd(3+) ions...
September 22, 2017: Methods and Applications in Fluorescence
https://www.readbyqxmd.com/read/28937885/vanishing-mandible-in-a-7-year-old-child-response-to-radiation-therapy
#9
Mounabati Mohapatra, Ashok Kumar Jena, Arun Kumar Dandapat, Sombir Singh
Massive osteolysis in a 7-year old child is a rare condition. The etiology of massive osteolysis is unknown and it results in the progressive destruction of bony structures. There is no standard therapy available in the literature. Conservative treatment is often used for its management. Radiotherapy is considered as an accepted form of treatment with greater chance of success when it is used in the early course of disease. There are few case reports in the literature in which radiotherapy has been used for the treatment...
September 22, 2017: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/28937838/protein-supplements-pros-and-cons
#10
Jay Rabindra Kumar Samal, Indira R Samal
To provide a comprehensive analysis of the literature examining the pros and cons of protein supplementation, various articles on protein supplementation were obtained from Google Scholar, PubMed, and National Center for Biotechnology Information. Over the past few years, protein supplementation has become commonplace for gym-goers as well as for the public. A large segment of the general population relies on protein supplementation for meal replacement, weight reduction, and purported health benefits. These protein supplements have varying pros and cons associated with them, which are often overlooked by the public...
September 22, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28937765/origin-of-substitution-mechanism-for-the-binding-of-organic-ligands-on-the-surface-of-cspbbr3-perovskite-nanocubes
#11
Vikash Kumar Ravi, Pralay K Santra, Niharika Joshi, Jeetender Chugh, Sachin Kumar Singh, Håkan Rensmo, Prasenjit Ghosh, Angshuman Nag
Optoelectronic properties of CsPbBr3 perovskite nanocubes (NCs) depend strongly on the interaction of the organic passivating molecules with the inorganic crystal. To understand this interaction, we employed a combination of synchrotron-based X-ray photoelectron spectroscopy (XPS), nuclear magnetic resonance (NMR) spectroscopy and first principles density functional theory (DFT) based calculations. XPS elucidated the internal structure of inorganic part in a layer-by-layer fashion, whereas, NMR characterized the organic ligands...
September 22, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28937632/design-and-analysis-of-a-low-latency-deterministic-network-mac-for-wireless-sensor-networks
#12
Prasan Kumar Sahoo, Sudhir Ranjan Pattanaik, Shih-Lin Wu
The IEEE 802.15.4e standard has four different superframe structures for different applications. Use of a low latency deterministic network (LLDN) superframe for the wireless sensor network is one of them, which can operate in a star topology. In this paper, a new channel access mechanism for IEEE 802.15.4e-based LLDN shared slots is proposed, and analytical models are designed based on this channel access mechanism. A prediction model is designed to estimate the possible number of retransmission slots based on the number of failed transmissions...
September 22, 2017: Sensors
https://www.readbyqxmd.com/read/28937590/logistic-model-to-support-service-modularity-for-the-promotion-of-reusability-in-a-web-objects-enabled-iot-environment
#13
Muhammad Golam Kibria, Sajjad Ali, Muhammad Aslam Jarwar, Sunil Kumar, Ilyoung Chong
Due to a very large number of connected virtual objects in the surrounding environment, intelligent service features in the Internet of Things requires the reuse of existing virtual objects and composite virtual objects. If a new virtual object is created for each new service request, then the number of virtual object would increase exponentially. The Web of Objects applies the principle of service modularity in terms of virtual objects and composite virtual objects. Service modularity is a key concept in the Web Objects-Enabled Internet of Things (IoT) environment which allows for the reuse of existing virtual objects and composite virtual objects in heterogeneous ontologies...
September 22, 2017: Sensors
https://www.readbyqxmd.com/read/28937387/malignant-chondroid-syringoma-of-thigh-with-late-metastasis-to-lung-a-very-rare-case-report
#14
Mayur Kothiya, Neha Mittal, Rajiv Kumar, Shubhada Kane
Mixed/biphasic tumors include epithelial-myoepithelial tumors, pleomorphic adenoma, matrix-producing tumors, cutaneous mixed tumors such as chondroid syringoma (CS), malignant mixed tumors (carcinosarcomas), pulmonary blastomas (in lung), and many others. Morphology may show overlap between various mixed tumors. At any particular site, whether these tumors are primary or metastasis from other sites is difficult to determine, more so if primary is unknown or not disclosed. CS is a rare benign mixed/biphasic skin adnexal tumor, considered as cutaneous counterpart of pleomorphic adenoma...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28937375/superficial-cd34-positive-fibroblastic-tumor-a-new-entity-case-report-and-review-of-literature
#15
Neelam Sood, Binit Kumar Khandelia
Earlier, categorized under low grade malignant fibrous histiocytoma and low grade sarcomas, 'superficial CD34 positive fibroblastic tumor', a newly proposed entity, is a low grade mesenchymal tumor of intermediate malignant potential. Morphological features include monomorphic neoplastic spindle cells arranged in a fascicular to storiform pattern along with sheets of pleomorphic epithelioid cells, and multinucleated giant cells with glassy cytoplasm. Diffuse vimentin and characteristic diffuse CD34 positivity is seen in all cases with few showing focal cytokeratin expression...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28937374/malignant-phyllodes-tumor-with-heterologous-differentiation-clinicopathological-spectrum-of-nine-cases-in-a-tertiary-care-institute-in-eastern-india
#16
Mamita Nayak, Susama Patra, Pritinanda Mishra, Nibedita Sahoo, Prakash Kumar Sasmal, Tushar Subhadarshan Mishra
Phyllodes tumors are uncommon fibroepithelial neoplasms of breast. Heterologous sarcomatous differentiation of malignant phyllodes tumor (MPT) is a rare phenomenon as shown in the literature. Herein we report a series of nine cases from a tertiary care centre in Eastern India. Patients demographic data and clinical details were obtained from the medical records. Histopathology and immunohistochemical studies were analysed and diagnosed accordingly. Out of 38 cases of PT, 13 were found to be MPT, of which 9 cases showed heterologous differentiation in the form of angiosarcoma, fibrosarcoma, undifferentiated sarcoma, extensive squamous differentiation and with lipomatous metaplasia...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28937365/immunohistochemical-characterization-of-glandular-elements-in-glandular-cardiac-myxoma-study-of-six-cases
#17
Devajit Nath, Sudheer Arava, Ruma Ray, Amol Kumar Bhoje, Rachit Saxena, Shiv Kumar Chaudhary
Back ground: Glandular cardiac myxoma has varying clinical presentation with uncertain histogenesis and debatable immunohistochemical profile. Glandular epithelial differentiations are rare phenomenon known to be present as an intrinsic component of the tumor. The origin of the glands has been attributed to epithelial differentiation of a totipotent cardiomyogenic precursor cells or the entrapped foregut rests in the tumor. MATERIALS AND METHODS: Retrospective study includes six cases of glandular cardiac myxoma collected over a perior of 4 years...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28937270/feasibility-of-free-breathing-lung-mri-for-radiotherapy-using-non-cartesian-k-space-acquisition-schemes
#18
Shivani Kumar, Robba Rai, Alto Stemmer, Sonal Josan, Lois Holloway, Shalini Vinod, Daniel Moses, Gary Liney
OBJECTIVES: To test a free breathing MRI protocol for anatomical and functional assessment during lung cancer radiotherapy by assessing two non-cartesian acquisition schemes based on a T1W 3D gradient recall echo sequence: (i) stack-of stars (StarVIBE) and (ii) spiral (SpiralVIBE) trajectories Methods: MR images on five healthy volunteers were acquired on a wide bore 3T scanner (Skyra, Siemens Healthcare). Anatomical image quality was assessed on: (1) free breathing (StarVIBE), (2) the standard clinical sequence (VIBE) acquired in a 20 second compliant breath-hold and (3) 20 second non-complaint breath-hold...
September 13, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28937268/real-time-intra-procedural-18f-fdg-pet-ct-guided-biopsy-using-automated-robotic-biopsy-arm-ara-in-the-evaluation-of-thoracic-lesions-with-prior-inconclusive-biopsy-results
#19
Renjith Kalathoorakathu Radhakrishnan, Bhagwant Rai Mittal, Arun Kumar Reddy Gorla, Rajender Kumar Basher, Ashwani Sood, Amanjit Bal, Naveen Kalra, Niranjan Khandelwal, Navneet Singh, Digambar Behera
OBJECTIVE: The aim of this study was to assess the feasibility and appraise the diagnostic utility of real time 18F-FDG PET/CT guided biopsy under automated robotic biopsy arm (ARA) guidance for the evaluation of thoracic lesions with prior inconclusive biopsy results. METHODS: PET/CT guided biopsy of thoracic lesions was performed in patients who had at least one previous inconclusive biopsy. A total of 25 patients (Male: Female- 18 males, 7 females; Age: Range- 13-75; mean- 53...
September 20, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28936996/caregiver-perceptions-on-intensive-care-a-qualitative-study-from-southern-india
#20
Shuba Kumar, Jony Christina, Anna Revathi Jagadish, John Victor Peter, Kurien Thomas, Thambu David Sudarsanam
BACKGROUND: Admission of a patient to an intensive care unit (ICU) can result in tremendous stress to family caregivers not only because of the need to provide physical and emotional support to the sick relative, but also due to the burden of decision-making on behalf of the critically ill person. We enquired about family caregivers' perspectives on intensive care, the challenges they faced with decision-making and their perceptions on the nature of their interactions with healthcare providers...
May 2017: National Medical Journal of India
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