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https://www.readbyqxmd.com/read/29793186/excess-sludge-disruption-and-pollutant-removal-from-tannery-effluent-by-upgraded-activated-sludge-system
#1
Vijay Sodhi, Ajay Bansal, Mithilesh Kumar Jha
This study proposed a maintenance metabolism based upgraded activated sludge as MANODOX system that restricts excess biosludge generation from high strength real tannery effluent. The MANODOX experimental demonstration has been done using a sequenced operational arrangement of a MBBR, anaerobic digester, and oxidation ditch connected to CAS reactor, discussed in detail manner. Experimental trends revealed a prominently lower sludge yield upto 0.271 gVSS/gCOD (72% overall sludge reduction) that corresponds to parallel run CAS (0...
April 30, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29793155/lessons-from-mosquitoes-painless-piercing
#2
Dev Gurera, Bharat Bhushan, Navin Kumar
Arthropods are the largest group of the living organisms. They attack other organisms by biting, stinging, or piercing and sucking. Among various medically important arthropods, which feed on living hosts, mosquitoes' piercing spread viruses which have been reported to cause the highest number of deaths annually. The primary cause of the deaths is malaria, which is spread by infected mosquitoes' piercing. This study aims at elucidating lessons from mosquitoes' painless piercing. Mosquitoes pierce using their fascicle, which is a bundle of coherently functioning six stylets...
May 18, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29792921/characterization-of-solution-stress-degradation-products-of-aliskiren-and-prediction-of-their-physicochemical-and-admet-properties
#3
Bhoopendra Singh Kushwah, Jugal Gupta, Dilip Kumar Singh, Moolchand Kurmi, Archana Sahu, Saranjit Singh
Forced degradation studies on aliskiren were carried out according to ICH and WHO guidelines. Six degradation products were formed in total in the solution state. Their separation among themselves and from the drug was successfully achieved on a C-18 column utilizing acetonitrile and phosphate buffer (pH 3.0) in the mobile phase, which was run in a gradient mode. To characterize them, a complete mass fragmentation pathway of the drug was first established with the help of MS/TOF and MSn data. This was followed by LC-MS/TOF studies on the degradation products...
May 21, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29792782/25-hydroxyvitamin-d3-and-1-25-dihydroxyvitamin-d3-as-an-antiviral-and-immunomodulator-against-herpes-simplex-virus-1-infection-in-hela-cells
#4
Archit Kumar, Mini P Singh, Ragini S Kumar, Radha Kanta Ratho
The antiviral and immunomodulatory role of vitamin D has been shown in various viral infections. However, there is scanty literature available about the effect of vitamin D supplementation in herpes simplex virus-1 (HSV-1) infection. Therefore, the present study aimed to evaluate the role of two different forms of vitamin D: 25-hydroxyvitamin D3 (25D3) and 1,25-dihydroxyvitamin D3 (1,25D3) against HSV-1 in HeLa cells. The HeLa cells were supplemented with either 25D3 or 1,25D3 before HSV-1 infection and were studied after 6, 12, and 24 h postinfection (p...
May 24, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29792728/single-acquisition-triple-bolus-dual-energy-ct-protocol-for-comprehensive-evaluation-of-renal-masses-a-single-center-randomized-noninferiority-trial
#5
Dinesh Manoharan, Sanjay Sharma, Chandan J Das, Rajeev Kumar, Geetika Singh, Pratik Kumar
OBJECTIVE: The primary objective of this study was to compare triple-bolus dual-energy CT (DECT) against standard triple-phase MDCT in terms of appropriateness of patient treatment. SUBJECTS AND METHODS: One hundred twenty-four patients with suspected renal masses seen at ultrasound were randomized into triple-bolus DECT and triple-phase MDCT groups. Patients in the triple-bolus DECT group underwent synchronous corticomedullary nephrographic delayed-phase triple-bolus DECT...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29792710/measuring-the-adhesion-forces-for-the-multivalent-binding-of-vancomycin-conjugated-dendrimer-to-bacterial-cell-wall-peptide
#6
Elizabeth Peterson, Christine Joseph, Hannah Peterson, Rachael Bouwman, Shengzhuang Tang, Jayme Cannon, Kumar Sinniah, Seok Ki Choi
Multivalent ligand-receptor interaction provides the fundamental basis for the hypothetical notion that high binding avidity relates to the strong force of adhesion. Despite its increasing importance in the design of targeted nanoconjugates, an understanding of the physical forces underlying the multivalent interaction remains a subject of urgent investigation. In this study, we designed three vancomycin (Van)-conjugated dendrimers G5(Van)n (n = mean valency = 0, 1, 4) for bacterial targeting with generation 5 (G5) poly(amidoamine) dendrimer as a multivalent scaffold, and evaluated both their binding avidity and physical force of adhesion to a bacterial model surface by employing surface plasmon resonance (SPR) spectroscopy and atomic force microscopy (AFM)...
May 24, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29792682/calix-4-arene-based-redox-sensitive-molecular-probe-for-sers-guided-recognition-of-labile-iron-pool-in-tumor-cells
#7
Padincharapad Sreedevi, Jyothi B Nair, Preethanuj Preethalayam, Benadicta S Jeeja, Cherumuttathu H Suresh, Kaustabh Kumar Maiti, Ramavarma Luxmi Varma
Targeting the intracellular 'labile' iron pool is turned as a key modulator for cancer progression since the former is responsible for several pathological processes in tumor cells. Herein, we report a non- fluorescent calix[4]arene based triazole appended molecular probe (PTBC) for redox-specific detection of Fe3+ under physiological condition by UV-vis, FT-IR, 1H NMR, HR-MS spectroscopies, ITC and the binding strategy between Calix[4]arene and Fe3+ was modeled by DFT calculations. As a new insight PTBC probe showed significant Raman fingerprint through surface enhanced Raman scattering (SERS) modality revealing the ultrasensitive detection of Fe3+ with a LOD of 2 nM...
May 24, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29792418/self-assembled-pd-ii-6-molecular-spheroids-and-their-proton-conduction-property
#8
Rupak Saha, Aloke Kumar Ghosh, Rudra Narayan Samajdar, Partha Sarathi Mukherjee
A series of molecular spheroids (SP1-SP4) was synthesized using pseudolinear bisimidazole and bisbenzimidazole donors in combination with Pd(NO3 )2 acceptor via coordination-driven self-assembly. They were characterized by NMR and mass spectrometry, and the solid-state structures of SP1 and SP3 were confirmed by X-ray diffraction. Crystal packing revealed the presence of molecular channels with water molecules in the channels as proton source. All the systems showed proton conductivity across a wide range of temperature and relative humidity...
May 24, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29792343/plasma-initiated-graft-polymerization-as-an-immobilization-platform-for-metal-free-russian-propolis-ethanol-extracts-designed-specifically-for-biomaterials
#9
Ashwin Ambi, Carolina Vera, Nisharg Parikh, Naidel Perez, Anthony Lopez Rojas, Sanket Kumar, Christopher Stradford, Katherine Borbon, Julia Bryan, Christian Traba
The antibacterial and anti-biofilm activities of propolis have been intensively reported. However, the application of this folk remedy as a means to prevent biomedical implant contamination has yet to be completely evaluated. In response to the significant resistant and infectious attributes of biofilms, biomaterials engineered to possess specific chemical and physical properties were immobilized with metal free Russian propolis ethanol extracts (MFRPEE), a known antibacterial agent. The results obtained from this study begin to examine the application of MFRPEE as a novel alternative method for the prevention of medical and biomedical implant infections...
May 24, 2018: Biofouling
https://www.readbyqxmd.com/read/29792307/putative-vaccine-candidates-and-drug-targets-identified-by-reverse-vaccinology-and-subtractive-genomics-approaches-to-control-haemophilus-ducreyi-the-causative-agent-of-chancroid
#10
Alissa de Sarom, Arun Kumar Jaiswal, Sandeep Tiwari, Letícia de Castro Oliveira, Debmalya Barh, Vasco Azevedo, Carlo Jose Oliveira, Siomar de Castro Soares
Chancroid is a sexually transmitted infection (STI) caused by the Gram-negative bacterium Haemophilus ducreyi The control of chancroid is difficult and the only current available treatment is antibiotic therapy; however, antibiotic resistance has been reported in endemic areas. Owing to recent outbreaks of STIs worldwide, it is important to keep searching for new treatment strategies and preventive measures. Here, we applied reverse vaccinology and subtractive genomic approaches for the in silico prediction of potential vaccine and drug targets against 28 strains of H...
May 2018: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29792268/toward-individual-glomerular-phenotyping-advent-of-precision-medicine-in-kidney-biopsies
#11
Kumar Sharma, Ljiljana Paša-Tolić
The road to precision medicine for nephrology is approaching quickly. In the present volume, the glomerular proteome has now been characterized at a single glomerulus level in mouse and human kidneys. Using the Single-Pot Solid-Phase-enhanced Sample Preparation (SP3) approach the authors demonstrated that LAMP1 is a key lysosomal protein that is increased in glomerular diseases and may play a pathogenic role.
June 2018: Kidney International
https://www.readbyqxmd.com/read/29792236/evaluation-of-gamma-radiation-induced-biochemical-changes-in-skin-for-dose-assesment-a-study-on-small-experimental-animals
#12
Sandeep Kumar Soni, Mitra Basu, Priyanka Agrawal, Aseem Bhatnagar, Neelam Chhillar
OBJECTIVE: Researchers have been evaluating several approaches to assess acute radiation injury/toxicity markers owing to radiation exposure. Keeping in mind this background, we assumed that whole-body irradiation in single fraction in graded doses can affect the antioxidant profile in skin that could be used as an acute radiation injury/toxicity marker. METHODS: Sprague-Dawley rats were treated with CO-60 gamma radiation (dose: 1-5 Gy; dose rate: 0.85 Gy/minute)...
May 24, 2018: Disaster Medicine and Public Health Preparedness
https://www.readbyqxmd.com/read/29792165/molecular-characterization-and-differential-expression-suggested-diverse-functions-of-p-type-ii-ca-2-atpases-in-triticum-aestivum-l
#13
Mehak Taneja, Santosh Kumar Upadhyay
BACKGROUND: Plant P-type II Ca2+ ATPases are formed by two distinct groups of proteins (ACAs and ECAs) that perform pumping of Ca2+ outside the cytoplasm during homeostasis, and play vital functions during development and stress management. In the present study, we have performed identification and characterisation of P-type II Ca 2+ ATPase gene family in an important crop plant Triticum aestivum. RESULTS: Herein, a total of 33 TaACA and 9 TaECA proteins were identified from the various chromosomes and sub-genomes of Triticum aestivum...
May 23, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29792162/overlapping-but-distinct-topology-for-zebrafish-v2r-like-olfactory-receptors-reminiscent-of-odorant-receptor-spatial-expression-zones
#14
Gaurav Ahuja, Vera Reichel, Daniel Kowatschew, Adnan S Syed, Aswani Kumar Kotagiri, Yuichiro Oka, Franco Weth, Sigrun I Korsching
BACKGROUND: The sense of smell is unrivaled in terms of molecular complexity of its input channels. Even zebrafish, a model vertebrate system in many research fields including olfaction, possesses several hundred different olfactory receptor genes, organized in four different gene families. For one of these families, the initially discovered odorant receptors proper, segregation of expression into distinct spatial subdomains within a common sensory surface has been observed both in teleost fish and in mammals...
May 23, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29792028/in-situ-structural-elucidation-and-selective-pb2-ion-recognition-of-polydopamine-film-formed-by-controlled-electrochemical-oxidation-of-dopamine
#15
K S Shalini Devi, Sharu Jacob, Annamalai Senthil Kumar
Owing to the versatility and biocompatibility, a self-polymerized DA (in presence of air at pH 8.5 tris buffer solution) as a polydopamine (pDA) film has been used for a variety of applications. Indeed, instability under electrified condition (serious surface-fouling) and structural ambiguity of the pDA have been found to be unresolved problems. Previously, pDA films (has hygroscopic and insoluble property) prepared by various controlled chemical oxidation methods have been examined for the structural analysis using ex-situ solid-state NMR and Mass Spectroscopic techniques...
May 24, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29791900/re-operative-pancreaticoduodenectomy-challenges-and-outcomes
#16
Manish S Bhandare, Nikhil Mehta, Vikram Chaudhari, Naveena An Kumar, Esha Pai, Mahesh Goel, Shailesh V Shrikhande
BACKGROUND: Tata Memorial Centre (TMC) is a high-volume centre for pancreatic tumour resections. We found a continually increasing referral of pancreatic tumours for re-evaluation for surgery, after an initial unsuccessful attempt at resection. AIM: To evaluate reasons of initial in-operability, the feasibility of re-operative pancreatico-duodenectomy (R-PD) and short- and long-term outcomes after R-PD. METHODS: Data was collected from a prospective database of GI and hepato-pancreato-biliary service, TMC, Mumbai from January 2008 to December 2016...
May 23, 2018: Digestive Surgery
https://www.readbyqxmd.com/read/29791890/a-robust-and-non-invertible-fingerprint-template-for-fingerprint-matching-system
#17
Amit Kumar Trivedi, Dalton Meitei Thounaojam, Shyamosree Pal
Fingerprint Recognition System is widely deployed in variety of application domain, ranging from forensic to mobile phones. Its widespread deployment in various applications were person authentication are required, has caused concern that a leaked fingerprint template may be used to reconstruct the original fingerprint and the reconstructed fingerprint can be used to circumvent all the applications the person is enrolled. In this paper, a non-invertible fingerprint template that stores only the relative geometric information about the minutiae points is proposed...
May 20, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29791876/extraction-and-characterization-of-cashew-tree-anacardium-occidentale-gum-use-in-aceclofenac-dental-pastes
#18
M Saquib Hasnain, Poonam Rishishwar, Sanjay Rishishwar, Sadath Ali, Amit Kumar Nayak
In the current work, the usefulness of extracted cashew tree gum (CG) as pharmaceutical excipient in dental pastes containing AC (for the pain management in the periodontitis) was investigated. CG was extracted from crude exudate of cashew tree (Anacardium occidentale, family: Anacardiaceae) (yield 19.22%). Physicochemical characteristics like colour, odour, taste, solubility, pH and viscosity of extracted CG were estimated; the phytochemical identification tests indicated the presence of carbohydrates and mucilage within it...
May 20, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29791856/activation-of-the-arterial-program-drives-development-of-definitive-hemogenic-endothelium-with-lymphoid-potential
#19
Mi Ae Park, Akhilesh Kumar, Ho Sun Jung, Gene Uenishi, Oleg V Moskvin, James A Thomson, Igor I Slukvin
Understanding the pathways guiding the development of definitive hematopoiesis with lymphoid potential is essential for advancing human pluripotent stem cell (hPSC) technologies for the treatment of blood diseases and immunotherapies. In the embryo, lymphoid progenitors and hematopoietic stem cells (HSCs) arise from hemogenic endothelium (HE) lining arteries but not veins. Here, we show that activation of the arterial program through ETS1 overexpression or by modulating MAPK/ERK signaling pathways at the mesodermal stage of development dramatically enhanced the formation of arterial-type HE expressing DLL4 and CXCR4...
May 22, 2018: Cell Reports
https://www.readbyqxmd.com/read/29791750/tiled-array-based-sequencing-identifies-enrichment-of-loss-of-function-variants-in-the-highly-homologous-filaggrin-gene-in-african-american-children-with-severe-atopic-dermatitis
#20
Mary Elizabeth Mathyer, Ashley M Quiggle, X F Colin C Wong, Simon L I J Denil, Monique G Kumar, Heather M Ciliberto, Susan J Bayliss, John E Common, Cristina de Guzman Strong
Filaggrin (FLG) loss of function (LOF) variants are a major risk factor for the common inflammatory skin disease, atopic dermatitis (AD), and are often population-specific. African American (AA) children are disproportionately affected with AD, often later developing asthma and/or allergic rhinitis and comprise an atopy health disparity group for which the role of FLG LOF is not well known. Discovery of FLG LOF using exome sequencing is challenging given the known difficulties for accurate short-read alignment to FLG's high homology repeat variation...
May 23, 2018: Experimental Dermatology
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