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https://www.readbyqxmd.com/read/29337671/spectrophotometric-method-for-simultaneous-determination-of-valsartan-and-substances-from-the-group-of-statins-in-binary-mixtures
#1
Mariusz Stolarczyk, Anna Apola, Anna Maślanka, Anna Kwiecień, Włodzimierz Opoka
Applicability of derivative spectrophotometry for the determination of valsartan in the presence of a substance from the group of statins was checked. The obtained results indicate that the proposed method may be effective by using appropriate derivatives: for valsartan and fluvastatin - D1, D2 and D3, for valsartan and pravastatin - D1 and D3, for valsartan and atorvastatin - D2 and D3. The method was characterized by high sensitivity and accuracy. Linearity was maintained in the following ranges: 9.28-32...
December 20, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/29304533/release-of-platelet-derived-sphingosine-1-phosphate-involves-multidrug-resistance-protein-4-mrp4-abcc4-and-is-inhibited-by-statins
#2
Katja Vogt, Shailaja Mahajan-Thakur, Robert Wolf, Susanne Bröderdorf, Conny Vogel, Andreas Böhm, Christoph A Ritter, Markus Gräler, Stefan Oswald, Andreas Greinacher, Heyo K Kroemer, Gabriele Jedlitschky, Bernhard H Rauch
Sphingosine-1-phosphate (S1P) is a potent lipid mediator released from activated platelets by an adenosine triphosphate (ATP)-dependent export mechanism. A candidate transport protein is the multidrug resistance protein 4 (MRP4/ABCC4), an ATP-dependent transporter highly expressed in platelets. Furthermore, several statins are known to affect platelet functions and exhibit antithrombotic properties. This study determines the involvement of MRP4 in the transport of S1P and a possible interference by statins...
January 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29286128/protection-against-monocrotaline-induced-pulmonary-arterial-hypertension-and-caveolin-1-downregulation-by-fluvastatin-in-rats
#3
Shaoping Zhu, Junyu Wang, Xianguo Wang, Jinping Zhao
Statins are Hydroxymethylglutaryl-coenzyme A reductase inhibitors, which are typically used to lower blood cholesterol. Additional beneficial effects, including improvement to pulmonary arterial hypertension (PAH), have also been confirmed. However, the mechanisms underlying this improvement have not yet been clarified. The present study was conducted to determine if fluvastatin was protective against experimental PAH development and to investigate the potential effects of fluvastatin on caveolin‑1 (cav‑1) expression...
December 22, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29229608/statin-induced-cancer-cell-death-can-be-mechanistically-uncoupled-from-prenylation-of-ras-family-proteins
#4
Rosemary Yu, Joseph Longo, Jenna E van Leeuwen, Peter J Mullen, Wail Ba-Alawi, Benjamin Haibe-Kains, Linda Z Penn
The statin family of drugs preferentially trigger tumor cell apoptosis by depleting mevalonate pathway metabolites farnesyl pyrophosphate (FPP) and geranylgeranyl pyrophosphate (GGPP), which are used for protein prenylation, including the oncoproteins of the RAS superfamily. However, accumulating data indicate that activation of the RAS superfamily are poor biomarkers of statin sensitivity, and the mechanism of statin-induced tumor-specific apoptosis remains unclear. Here we demonstrate that cancer cell death triggered by statins can be uncoupled from prenylation of the RAS superfamily of oncoproteins...
December 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/29212185/hyaluronic-acid-enhances-cell-migration-and-invasion-via-the-yap1-taz-rhamm-axis-in-malignant-pleural-mesothelioma
#5
Wataru Shigeeda, Masahiko Shibazaki, Shinji Yasuhira, Tomoyuki Masuda, Tatsuo Tanita, Yuka Kaneko, Tatsuhiro Sato, Yoshitaka Sekido, Chihaya Maesawa
Most malignant mesotheliomas (MPMs) frequently show activated forms of Yes-associated protein 1 (YAP1) and transcriptional co-activator with PDZ-binding motif (TAZ), which transcriptionally regulates the receptor for hyaluronic acid-mediated motility (RHAMM). As RHAMM is involved in cell migration and invasion in various tumors, we speculated that hyaluronic acid (HA) in pleural fluid might affect the progression of mesothelioma by stimulating cell migration and invasion through RHAMM. The level of RHAMM expression was decreased by YAP1/TAZ knockdown, and conversely increased by forced expression of the active form of YAP1, suggesting that RHAMM was regulated by YAP1/TAZ in MPM cells...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29205633/a-combined-connectivity-mapping-and-pharmacoepidemiology-approach-to-identify-existing-medications-with-breast-cancer-causing-or-preventing-properties
#6
John Busby, Liam Murray, Ken Mills, Shu-Dong Zhang, Fabio Liberante, Chris R Cardwell
PURPOSE: We applied a novel combined connectivity mapping and pharmacoepidemiological approach to identify medications that alter breast cancer risk. METHODS: The connectivity mapping process identified 6 potentially cancer-causing (meloxicam, azithromycin, rizatriptan, citalopram, rosiglitazone, and verapamil) and 4 potentially cancer-preventing (bendroflumethiazide, sertraline, fluvastatin, and budesonide) medications that were suitable for pharmacoepidemiological investigation...
December 4, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29155776/differential-effects-of-lipid-lowering-drugs-in-modulating-morphology-of-cholesterol-particles
#7
Shanmugavel Madasamy, David Liu, Jason Lundry, Benjamin Alderete, Raymond Kong, J Paul Robinson, Alan H B Wu, Edward P Amento
Treatment of dyslipidemia patients with lipid-lowering drugs leads to a significant reduction in low-density lipoproteins (LDL) level and a low to moderate level of increase in high-density lipoprotein (HDL) cholesterol in plasma. However, a possible role of these drugs in altering morphology and distribution of cholesterol particles is poorly understood. Here, we describe the in vitro evaluation of lipid-lowering drug effects in modulating morphological features of cholesterol particles using the plaque array method in combination with imaging flow cytometry...
November 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29112402/combined-falling-drop-open-port-sampling-interface-system-for-automated-flow-injection-mass-spectrometry
#8
Gary J Van Berkel, Vilmos Kertesz, Matt Orcutt, Adam Bentley, Jim Glick, Jimmy Flarakos
The aim of this work was to demonstrate and to evaluate the analytical performance of a combined falling drop/open port sampling interface (OPSI) system as a simple noncontact, no-carryover, automated system for flow injection analysis with mass spectrometry. The falling sample drops were introduced into the OPSI using a widely available autosampler platform utilizing low cost disposable pipet tips and conventional disposable microtiter well plates. The volume of the drops that fell onto the OPSI was in the 7-15 μL range with an injected sample volume of several hundred nanoliters...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29096858/management-of-patients-with-statin-intolerance
#9
Sabine Fischer, Ulrich Julius
In recent years statins have become an established option in lipid-lowering pharmacotherapy despite the fact that statin intolerance is fairly common. When muscle pains and/or an elevation of the creatine kinase appear, the dose must be lowered in patients with slight symptoms or stopped altogether if the symptoms are more severe. When the symptoms are alleviated and creatine kinase is normalized, re-exposition can be considered. If symptoms recur, treatment with another statin should be attempted - in these cases pravastatin or fluvastatin are recommended, although they are less effective in reducing LDL cholesterol...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29067253/evidence-based-review-of-statin-use-in-patients-with-hiv-on-antiretroviral-therapy
#10
REVIEW
Daniel B Chastain, Kayla R Stover, Daniel M Riche
INTRODUCTION: As a result of improved safe and effective therapeutic options for human immunodeficiency virus (HIV), life expectancy of those living with HIV is increasing leading to new challenges (e.g., management of chronic diseases). Some chronic diseases (e.g., cardiovascular disease [CVD]), are up to two times more prevalent in patients with HIV. Statins are a mainstay of therapy for prevention of CVD; but, clinicians should be aware that not all statins are appropriate for use in the HIV population, especially those receiving antiretroviral therapy (ART)...
June 2017: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/29017950/the-synergistic-effects-of-valproic-acid-and-fluvastatin-on-apoptosis-induction-in-glioblastoma-multiforme-cell-lines
#11
Yung-Lung Chang, Li-Chun Huang, Ying-Chuan Chen, Yi-Wen Wang, Dueng-Yuan Hueng, Shih-Ming Huang
Glioblastoma multiforme (GBM) is the most common primary central nervous system malignant tumor. It responds poorly to standard therapies, such as surgical resection, radiation therapy and chemotherapy. Many chemotherapeutic drugs are focused on apoptosis induction and radiation sensitivity. Inhibition of histone acetylation via histone deacetylase inhibitor (HDACI) is one such strategy. Statins (or 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors) are classical drugs used to lower cholesterol but also inhibitors of histone deacetylation activity...
November 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28951255/sub-therapeutic-doses-of-fluvastatin-and-valsartan-are-more-effective-than-therapeutic-doses-in-providing-beneficial-cardiovascular-pleiotropic-effects-in-rats-a-proof-of-concept-study
#12
Miodrag Janić, Mojca Lunder, Alenka France Štiglic, Aleš Jerin, Milan Skitek, Darko Černe, Janja Marc, Gorazd Drevenšek, Mišo Šabovič
BACKGROUND: Statins and sartans can, in therapeutic doses, induce pleiotropic cardiovascular effects. Similar has recently been shown also for sub-therapeutic doses. We thus explored and compared the cardiovascular pleiotropic efficacy of sub-therapeutic vs. therapeutic doses. METHODS: Wistar rats were randomly divided into 7 groups receiving fluvastatin, valsartan and their combination in sub-therapeutic and therapeutic doses, or saline. After 6weeks, the animals were euthanised, their hearts and thoracic aortas isolated, and blood samples taken...
September 23, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28933256/combined-effect-of-telmisartan-and-fluvastatin-on-arachidonic-acid-metabolism-in-human-liver-microsomes
#13
Yuka Kato, Yuji Mukai, Anders Rane, Nobuo Inotsume, Takaki Toda
Epoxyeicosatrienoic acids (EETs), metabolites of arachidonic acid (AA) via cytochrome P450s, have a protective effect on the cardiovascular system involving vasodilation. We have previously demonstrated that telmisartan (TEL) inhibits EETs production from AA in vitro. The objectives of the study were to examine the inhibitory effect of fluvastatin (FLU), an inhibitor of CYP2C9, and the combined effect of TEL and FLU on the production of EETs using human liver microsomes. The combined effect of TEL and FLU was evaluated using two methods, the fixed concentration method and the fixed ratio method...
September 21, 2017: Xenobiotica; the Fate of Foreign Compounds in Biological Systems
https://www.readbyqxmd.com/read/28919704/secondary-prevention-of-major-cerebrovascular-events-with-seven-different-statins-a-multi-treatment-meta-analysis
#14
Ping Zhong, Danhong Wu, Xiaofei Ye, Ying Wu, Tuming Li, Shuwen Tong, Xueyuan Liu
BACKGROUND: Statins have been recommended for the use in atherosclerotic cardiovascular diseases, but different statins have distinct pharmacological characteristics. This multi-treatment meta-analysis aimed to evaluate the efficacy of seven statins in the secondary prevention of major cerebrovascular events (CVEs). METHODS AND ANALYSES: The PubMed, Embase, Cochrane Database of Systematic Reviews and Cochrane Central Register of Controlled Trials were searched to identify studies published between January 1, 2011, and June 30, 2016...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28883515/factor-xa-mediates-calcium-flux-in-endothelial-cells-and-is-potentiated-by-igg-from-patients-with-lupus-and-or-antiphospholipid-syndrome
#15
Bahar Artim-Esen, Natalia Smoktunowicz, Thomas McDonnell, Vera M Ripoll, Charis Pericleous, Ian Mackie, Eifion Robinson, David Isenberg, Anisur Rahman, Yiannis Ioannou, Rachel C Chambers, Ian Giles
Factor (F) Xa reactive IgG isolated from patients with antiphospholipid syndrome (APS) display higher avidity binding to FXa with greater coagulant effects compared to systemic lupus erythematosus (SLE) non APS IgG. FXa signalling via activation of protease-activated receptors (PAR) leads to increased intracellular calcium (Ca(2+)). Therefore, we measured alterations in Ca(2+) levels in human umbilical vein endothelial cells (HUVEC) following FXa-mediated PAR activation and investigated whether FXa reactive IgG from patients with APS or SLE/APS- alter these responses...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28840831/fluvastatin-use-and-risk-of-acute-pancreatitis-a-population-based-case-control-study-in-taiwan
#16
Kuan-Fu Liao, Po-Tsung Huang, Ching-Chun Lin, Cheng-Li Lin, Shih-Wei Lai
OBJECTIVES: This study aimed to examine the association between fluvastatin use and acute pancreatitis in Taiwan. METHODS: Using the database from the Taiwan National Health Insurance (NHI) Program, we designed a case-control study which consisted of 3501 individuals aged 20-84 with new at-the-time diagnoses acute pancreatitis as the case group and 8373 randomly selected individuals without acute pancreatitis as the control group during the period of 1998-2011. Both groups were matched for sex, age, and index year of being diagnosed with acute pancreatitis...
September 2017: BioMedicine
https://www.readbyqxmd.com/read/28782480/recent-progress-in-biological-activities-of-indole-and-indole-alkaloids
#17
O M Singh, Thokchom Prasanta Singh
The indole scaffold is a prominent and privileged structural motif found in numerous natural products and in a wide range of bioactive heterocycles. Starting from the simple structural framework of serotonin, the well known neurotransmitter to complex alkaloids which are used clinically as anticancer agent, mitomycin C, and the antihypertensive alkaloid reserpine, the indole moiety is considered as the active principle. Thus over the past decade, a large number of indole-containing compounds have revealed remarkable pharmacological activity and their utility as therapeutic agents have attracted considerable attention from chemists...
August 7, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/28744693/vegfa-involves-in-the-use-of-fluvastatin-and-zoledronate-against-breast-cancer
#18
Haihong Pu, Qingyuan Zhang, Chunbo Zhao, Lei Shi, Yan Wang, Jingxuan Wang, Minghui Zhang
Our study aimed to identify key genes involved in the use of fluvastatin and zoledronate against breast cancer, as well as to investigate the roles of vascular endothelial growth factor A (VEGFA) in the malignant behaviors of breast cancer cells. The expression data GSE33552 was downloaded from Gene Expression Omnibus database, including mocked-, fluvastatin- and zoledronate-treated MDA-MB-231 cells. Differentially expressed genes (DEGs) were identified in fluvastatin- and zoledronate-treated cells using limma package, respectively...
July 25, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28741244/efficacy-and-safety-of-alternate-day-versus-daily-dosing-of-statins-a-systematic-review-and-meta-analysis
#19
REVIEW
Kamal Awad, Dimitri P Mikhailidis, Peter P Toth, Steven R Jones, Patrick Moriarty, Gregory Y H Lip, Paul Muntner, Alberico L Catapano, Michael J Pencina, Robert S Rosenson, Jacek Rysz, Maciej Banach
PURPOSE: We conducted a meta-analysis of randomized controlled trials (RCTs) and quasi-RCTs to synthesize evidence about the efficacy and safety of alternate-day vs daily dosing of statins. METHODS: We searched selected databases through January 2, 2017 to identify relevant RCTs and quasi-RCTs. The primary outcome was change in low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglycerides (TG), while secondary outcomes included adverse events and adherence...
August 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28722780/add-on-effects-of-fluvastatin-in-simeprevir-pegylated-interferon-ribavirin-combination-therapy-for-patients-with-genotype-1-hepatitis-c-virus-infection-a-randomized-controlled-study
#20
Goki Suda, Jun Ito, Atsushi Nagasaka, Yoshiya Yamamoto, Ken Furuya, Munenori Okamoto, Katsumi Terashita, Tomoe Kobayashi, Izumi Tsunematsu, Junichi Yoshida, Takashi Meguro, Masatsugu Ohara, Naoki Kawagishi, Megumi Kimura, Machiko Umemura, Takaaki Izumi, Yoko Tsukuda, Masato Nakai, Takuya Sho, Mitsuteru Natsuizaka, Kenichi Morikawa, Koji Ogawa, Naoya Sakamoto
BACKGROUND: The Japan Society of Hepatology guidelines indicate that HCV protease inhibitor combination therapy with simeprevir (SMV), pegylated-interferon (Peg-IFN), and ribavirin (RBV) is a therapeutic option for patients who fail to respond to a direct direct-acting antiviral (DAA) containing regimen. However, treatment outcomes have room for improvement. Fluvastatin (FLV) add-on treatment in Peg-IFN and RBV combination therapy for hepatitis C-infected patients significantly improved the sustained virological response (SVR), but the add-on effect of FLV on SMV combination therapy is not well understood...
July 19, 2017: Hepatology Research: the Official Journal of the Japan Society of Hepatology
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