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https://www.readbyqxmd.com/read/28930103/seasonal-variability-precipitating-hand-transplant-rejection
#1
Rachel G Lopdrup, Marvee Turk, Thet Su Win, Francisco M Marty, David Molway, Stefan G Tullius, Bohdan Pomahac, Simon G Talbot
No abstract text is available yet for this article.
October 2017: Transplantation
https://www.readbyqxmd.com/read/28926626/do-privacy-and-security-regulations-need-a-status-update-perspectives-from-an-intergenerational-survey
#2
Stacey Pereira, Jill Oliver Robinson, Hayley A Peoples, Amanda M Gutierrez, Mary A Majumder, Amy L McGuire, Mark A Rothstein
BACKGROUND: The importance of health privacy protections in the era of the "Facebook Generation" has been called into question. The ease with which younger people share personal information about themselves has led to the assumption that they are less concerned than older generations about the privacy of their information, including health information. We explored whether survey respondents' views toward health privacy suggest that efforts to strengthen privacy protections as health information is moved online are unnecessary...
2017: PloS One
https://www.readbyqxmd.com/read/28926569/am-i-who-i-say-i-am-unobtrusive-self-representation-and-personality-recognition-on-facebook
#3
Margeret Hall, Simon Caton
Across social media platforms users (sub)consciously represent themselves in a way which is appropriate for their intended audience. This has unknown impacts on studies with unobtrusive designs based on digital (social) platforms, and studies of contemporary social phenomena in online settings. A lack of appropriate methods to identify, control for, and mitigate the effects of self-representation, the propensity to express socially responding characteristics or self-censorship in digital settings, hinders the ability of researchers to confidently interpret and generalize their findings...
2017: PloS One
https://www.readbyqxmd.com/read/28922236/efficacy-outcome-measures-for-pediatric-procedural-sedation-clinical-trials-an-acttion-systematic-review
#4
Mark R Williams, Michael Nayshtut, Amie Hoefnagel, Andrew McKeown, Douglas W Carlson, Joseph Cravero, Jenifer Lightdale, Keira P Mason, Stephen Wilson, Dennis C Turk, Robert H Dworkin, Denham S Ward
Objective evaluations comparing different techniques and approaches to pediatric procedural sedation studies have been limited by a lack of consistency among the outcome measures used in assessment. This study reviewed those existing measures, which have undergone psychometric analysis in a pediatric procedural sedation setting, to determine to what extent and in what circumstances their use is justified across the spectrum of procedures, age groups, and techniques. The results of our study suggest that a wide range of measures has been used to assess the efficacy and effectiveness of pediatric procedural sedation...
September 14, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28920115/gold-nanodome-sers-platform-for-label-free-detection-of-protease-activity
#5
Pieter C Wuytens, Hans Demol, Nina Turk, Kris Gevaert, Andre G Skirtach, Mohamed Lamkanfi, Roel Baets
Surface-enhanced Raman scattering provides a promising technology for sensitive and selective detection of protease activity by monitoring peptide cleavage. Not only are peptides and plasmonic hotspots similarly sized, Raman fingerprints also hold large potential for spectral multiplexing. Here, we use a gold-nanodome platform for real-time detection of trypsin activity on a CALNNYGGGGVRGNF substrate peptide. First, we investigate the spectral changes upon cleavage through the SERS signal of liquid-chromatography separated products...
September 18, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28919432/chronic-pain-and-telomere-length-in-community-dwelling-adults-findings-from-the-1999-2002-national-health-and-nutrition-examination-survey
#6
Alta M Steward, Julia D Morgan, Juan P Espinosa, Dennis C Turk, Kushang V Patel
Chronic pain is a common condition associated with psychological distress, functional impairments, and age-associated comorbidity. Preliminary studies, based on relatively small sample sizes, suggest that the combination of chronic pain and stress is associated with telomere shortening, a widely recognized marker of cellular aging. We sought to determine the cross-sectional association of chronic pain with telomere length in 7,816 community-dwelling adults ages 20 and older who participated in the 1999-2002 National Health and Nutrition Examination Survey...
September 12, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28914373/the-therapeutic-effect-of-probiotics-on-rheumatoid-arthritis-a-systematic-review-and-meta-analysis-of-randomized-control-trials
#7
Abdelrahman Tarek Mohammed, Mohammed Khattab, Ali Mahmoud Ahmed, Tarek Turk, Nora Sakr, Adham M Khalil, Mohamed Abdelhalim, Bisher Sawaf, Kenji Hirayama, Nguyen Tien Huy
Rheumatoid arthritis is an autoimmune disease in which probiotics appears to have an immune modulating action along with decreased inflammatory process. Therefore, we aim to investigate the efficacy of probiotics as an adjuvant therapy for rheumatoid arthritis. A comprehensive literature search was performed using nine databases including PubMed and Web of Science. Interesting data was extracted and meta-analyzed. We assessed the risk of bias using Cochrane Collaboration's tool. The protocol was registered in PROSPERO (CRD 42016036769)...
September 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28904613/a-recursive-microfluidic-platform-to-explore-the-emergence-of-chemical-evolution
#8
David Doran, Marc Rodriguez-Garcia, Rebecca Turk-MacLeod, Geoffrey J T Cooper, Leroy Cronin
We propose that a chemically agnostic approach to explore the origin of life, using an automated recursive platform based on droplet microfluidics, could be used to induce artificial chemical evolution by iterations of growth, speciation, selection, and propagation. To explore this, we set about designing an open source prototype of a fully automated evolution machine, comprising seven modules. These modules are a droplet generator, droplet transfer, passive and active size sorting, splitter, incubation chamber, reservoir, and injectors, all run together via a LabVIEW(TM) program integration system...
2017: Beilstein Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28902644/serum-oxidized-low-density-lipoprotein-level-as-a-marker-of-oxidative-stress-in-patients-undergoing-hyperbaric-oxygen-therapy
#9
Kudret Keskin, Hakan Kilci, Gökhan Aksan, Gökhan Çetinkal, Süleyman Sezai Yıldız, Füsun Kocaman Türk, Gülsüm Bingöl
OBJECTIVE: Oxidative stress (OS) is involved in the pathogenesis of atherosclerosis. Hyperbaric oxygen therapy (HBOT), in which 100% oxygen is inhaled under hyperbaric pressure, may create OS. Therefore, the aim of this research was to measure the serum oxidized low-density lipoprotein (oxLDL) level in patients undergoing HBOT. METHODS: Twenty-nine patients who underwent HBOT to treat various diseases were enrolled in this study. The serum oxLDL level was measured at the beginning of the first and after the 10th therapy session...
September 2017: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://www.readbyqxmd.com/read/28901837/minimal-requirements-for-reverse-polymerization-and-trna-repair-by-trna-his-guanylyltransferase
#10
Riddhi Desai, Kunmo Kim, Hanna C Buechsenschuetz Allan W Chen, Yumin Bi, Mitchell R Mann, Matthew A Turk, Christina Z Chung, Ilka U Heinemann
tRNA(His) guanylyltransferase (Thg1) has unique reverse (3'-5') polymerase activity occurring in all three domains of life. Most eukaryotic Thg1 homologs are essential genes involved in tRNA(His) maturation. These enzymes normally catalyze a single 5' guanylation of tRNA(His) lacking the essential G(-1) identity element required for aminoacylation. Recent studies suggest that archaeal type Thg1, which includes most archaeal and bacterial Thg1 enzymes is phylogenetically distant from eukaryotic Thg1. Thg1 is evolutionarily related to canonical 5'-3' forward polymerases but catalyzes reverse 3'-5'polymerization...
September 13, 2017: RNA Biology
https://www.readbyqxmd.com/read/28895527/assessing-the-danger-of-self-sustained-hiv-epidemics-in-heterosexuals-by-population-based-phylogenetic-cluster-analysis
#11
Teja Turk, Nadine Bachmann, Claus Kadelka, Jürg Böni, Sabine Yerly, Vincent Aubert, Thomas Klimkait, Manuel Battegay, Enos Bernasconi, Alexandra Calmy, Matthias Cavassini, Hansjakob Furrer, Matthias Hoffmann, Huldrych F Günthard, Roger D Kouyos
Assessing the danger of transition of HIV transmission from a concentrated to a generalized epidemic is of major importance for public health. In this study, we develop a phylogeny-based statistical approach to address this question. As a case study, we use this to investigate the trends and determinants of HIV transmission among Swiss heterosexuals. We extract the corresponding transmission clusters from a phylogenetic tree. To capture the incomplete sampling, the delayed introduction of imported infections to Switzerland, and potential factors associated with basic reproductive number R0, we extend the branching process model to infer transmission parameters...
September 12, 2017: ELife
https://www.readbyqxmd.com/read/28892001/synthesis-and-immunological-evaluation-of-virus-like-particle-milbemycin-a%C3%A2-a%C3%A2-conjugates
#12
Andris Zeltins, Māris Turks, Dace Skrastina, Jevgeņija Lugiņina, Ieva Kalnciema, Ina Balke, Ērika Bizdēna, Vitalijs Skrivelis
Milbemycins are macrolide antibiotics with a broad spectrum of nematocidal, insecticidal, and acaricidal activity. To obtain milbemycin A₃/A₄ derivatives suitable for chemical conjugation to protein carriers (milbemycin haptens), succinate linker and a novel 17-atom-long linker containing a terminal carboxylic acid group were attached to the milbemycin core in a protecting group-free synthesis. The obtained milbemycin A₃/A₄ derivatives were coupled to Potato virus Y-like nanoparticles by the activated ester method...
September 11, 2017: Antibiotics
https://www.readbyqxmd.com/read/28890740/public-attitudes-towards-moral-enhancement-evidence-that-means-matter-morally
#13
Jona Specker, Maartje H N Schermer, Peter B Reiner
To gain insight into the reasons that the public may have for endorsing or eschewing pharmacological moral enhancement for themselves or for others, we used empirical tools to explore public attitudes towards these issues. Participants (N = 293) from the United States were recruited via Amazon's Mechanical Turk and were randomly assigned to read one of several contrastive vignettes in which a 13-year-old child is described as bullying another student in school and then is offered an empathy-enhancing program...
2017: Neuroethics
https://www.readbyqxmd.com/read/28890192/workplace-availability-risk-group-and-perceived-barriers-predictive-of-2016-17-influenza-vaccine-uptake-in-the-united-states-a-cross-sectional-study
#14
Paula M Luz, Riley E Johnson, Heidi E Brown
BACKGROUND: Seasonal influenza, though mostly self-limited in the healthy adult, may lead to severe disease and/or complications in subpopulations. Annual influenza vaccination is available in many countries with coverage goals rarely being met. We conducted a cross-sectional study of influenza vaccine uptake and explored socio-demographic, economic, and psychological factors that explained vaccine uptake. METHODS: The survey was administered via Amazon Mechanical Turk (MTurk) to United States residents in January 2017, using the Qualtrics platform...
September 7, 2017: Vaccine
https://www.readbyqxmd.com/read/28887803/psychosis-in-spinocerebellar-ataxias-a-case-series-and-study-of-tyrosine-hydroxylase-in-substantia-nigra
#15
Katherine W Turk, Margaret E Flanagan, Samuel Josephson, C Dirk Keene, Suman Jayadev, Thomas D Bird
Spinocerebellar ataxias are a genetically heterogeneous group of degenerative diseases typically characterized by progressive ataxia and to various degrees, neuropathy, amyotrophy, and ocular abnormalities. There is increasing evidence for non-motor manifestations associated with cerebellar syndromes including cognitive and psychiatric features. We studied a retrospective clinical case series of eight subjects with spinocerebellar ataxias (SCAs) 2, 3, 7, and 17, all displaying features of psychosis, and also measured tyrosine hydroxylase (TH) staining of the substantia nigra (SN) at autopsy, among four of the subjects...
September 8, 2017: Cerebellum
https://www.readbyqxmd.com/read/28886270/airway-epithelial-barrier-dysfunction-in-the-pathogenesis-and-prognosis-of-respiratory-tract-diseases-in-childhood-and-adulthood
#16
Hasan Yuksel, Ahmet Turkeli
The lungs are in direct contact with the environment through the tubular structure that constitutes the airway. Starting from the nasal orifice, the airway is exposed to foreign particles including infectious agents, allergens, and other substances that can damage the airways. Therefore, the airway must have a functional epithelial barrier both in the upper and lower airways to protect against these threats. As with the skin, it is likely that the pathogenesis of respiratory diseases is a consequence of epithelial barrier defects in these airways...
August 16, 2017: Tissue Barriers
https://www.readbyqxmd.com/read/28882810/study-of-methods-for-assessing-research-topic-elicitation-and-prioritization-smarter-study-protocol-to-compare-qualitative-research-methods-and-advance-patient-engagement-in-research
#17
Danielle C Lavallee, Bryan Comstock, Mary R Scott, Andrew L Avins, David R Nerenz, Todd C Edwards, Donald L Patrick, Sarah O Lawrence, Zoya Bauer, Anjali R Truitt, Jeffrey G Jarvik
BACKGROUND: Involving patients as partners in research is a defining characteristic of patient-centered outcomes research (PCOR). While patients' experiential knowledge of a health condition or treatment may yield research priorities not reflected by researchers and policy makers, the methods for identifying and effectively collaborating with patients are still evolving. Patient registries and crowdsourcing may offer ease of access and convenience to both researchers and patients. Surveys and focus groups, including online modalities, have been described for prioritizing research topics...
September 7, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28881145/secondhand-tobacco-smoke-and-severity-in-wheezing-children-nasal-oxidant-stress-and-inflammation
#18
Ozge Yilmaz, Ahmet Turkeli, Ece Onur, Sema Bilge, Hasan Yuksel
OBJECTIVES: Prenatal and postnatal smoke exposures are associated with many lung diseases in children due to impaired lung function, increased inflammation, and oxidative stress. We aimed to determine the influence of secondhand tobacco smoke exposure on the levels of nasal glutathione, IL-8, IL-17, MMP-9, and TIMP-1, as well as serum surfactant protein-D (SP-D) in wheezy children. METHODS: We enrolled 150 children with recurrent wheezing and recorded wheezing characteristics at enrollment...
September 7, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28878005/citrate-anticoagulant-improves-the-sensitivity-of-borreliella-borrelia-burgdorferi-plasma-culture
#19
Adriana R Marques, Xiuli Yang, Alexis A Smith, Xuran Zhuang, Siu-Ping Turk, Carla D Williams, Melissa A Law, Alan G Barbour, Utpal Pal
The ability of cultivating Borreliella (Borrelia) burgdorferi is a cornerstone of Lyme disease research.….
September 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28872495/dislocated-dental-prothesis-sitting-at-the-larynx-in-an-aphasic-patient-potentially-fatal-situation
#20
Bilge Türk, Özlem Ünsal, Kerem Sami Kaya, Berna Uslu Coşkun
INTRODUCTION: Foreign body in respiration tract is a life-threatening emergency and requires urgent treatment. The diagnosis and treatment requires awareness and suspicion of signs and symptoms of foreign body aspiration. CASE: A unique case of total dental prothesis aspiration of a 44-year-old aphasic patient is presented. The prothesis is completely removed from the larynx. DISCUSSION: Foreign-body aspiration is frequently suspected in children, it is rarely thought about in adults with subacute or chronic respiratory symptoms unless an evident history of an aspiration event is obtained...
September 1, 2017: Journal of Craniofacial Surgery
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