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https://www.readbyqxmd.com/read/27920470/nonalcoholic-fatty-liver-disease-a-multisystem-disease
#1
REVIEW
Ivana Mikolasevic, Sandra Milic, Tamara Turk Wensveen, Ivana Grgic, Ivan Jakopcic, Davor Stimac, Felix Wensveen, Lidija Orlic
Non-alcoholic fatty liver disease (NAFLD) is one of the most common comorbidities associated with overweight and metabolic syndrome (MetS). Importantly, NAFLD is one of its most dangerous complications because it can lead to severe liver pathologies, including fibrosis, cirrhosis and hepatic cellular carcinoma. Given the increasing worldwide prevalence of obesity, NAFLD has become the most common cause of chronic liver disease and therefore is a major global health problem. Currently, NAFLD is predominantly regarded as a hepatic manifestation of MetS...
November 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27919075/land-use-intensification-causes-multitrophic-homogenization-of-grassland-communities
#2
Martin M Gossner, Thomas M Lewinsohn, Tiemo Kahl, Fabrice Grassein, Steffen Boch, Daniel Prati, Klaus Birkhofer, Swen C Renner, Johannes Sikorski, Tesfaye Wubet, Hartmut Arndt, Vanessa Baumgartner, Stefan Blaser, Nico Blüthgen, Carmen Börschig, Francois Buscot, Tim Diekötter, Leonardo Ré Jorge, Kirsten Jung, Alexander C Keyel, Alexandra-Maria Klein, Sandra Klemmer, Jochen Krauss, Markus Lange, Jörg Müller, Jörg Overmann, Esther Pašalić, Caterina Penone, David J Perović, Oliver Purschke, Peter Schall, Stephanie A Socher, Ilja Sonnemann, Marco Tschapka, Teja Tscharntke, Manfred Türke, Paul Christiaan Venter, Christiane N Weiner, Michael Werner, Volkmar Wolters, Susanne Wurst, Catrin Westphal, Markus Fischer, Wolfgang W Weisser, Eric Allan
Land-use intensification is a major driver of biodiversity loss. Alongside reductions in local species diversity, biotic homogenization at larger spatial scales is of great concern for conservation. Biotic homogenization means a decrease in β-diversity (the compositional dissimilarity between sites). Most studies have investigated losses in local (α)-diversity and neglected biodiversity loss at larger spatial scales. Studies addressing β-diversity have focused on single or a few organism groups (for example, ref...
November 30, 2016: Nature
https://www.readbyqxmd.com/read/27914523/the-art-of-manuscript-review-and-manuscript-development
#3
EDITORIAL
Suzanne McDermott, Margaret A Turk
No abstract text is available yet for this article.
January 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/27914129/polymorphisms-of-promoter-region-of-tnf-%C3%AE-gene-in-iranian-azeri-turkish-patients-with-beh%C3%A3-et-s-disease
#4
Reza Abdolmohammadi, Mortaza Bonyadi
Behçet's disease (BD) is a complex chronic relapsing inflammatory disorder of unknown etiology. Alterations of the tumor necrosis factor (TNF) expression related to the polymorphic alleles of TNF gene may implicate a pathogenetic role in increased activity of this cytokine in BD. A current study aimed at investigating the possible association between BD and its clinical features in Iranian Azeri Turks with two functional TNF-α gene polymorphisms (at the positions of -238 and -857). A total number of 166 Iranian subjects were enrolled into two different groups; patients with BD (n = 64), and ethnically matched healthy controls (n = 101)...
January 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/27913263/experience-with-adapt-for-thrombectomy-in-distal-cerebral-artery-occlusions-causing-acute-ischemic-stroke
#5
Jan Vargas, Alex M Spiotta, Kyle Fargen, Raymond D Turner, Imran Chaudry, Aquilla Turk
BACKGROUND: Thromboembolic occlusion of distal branches in anterior and posterior circulation may produce severe clinical deficits. The ADAPT technique is a simple, fast method for achieving good angiographic and clinical outcomes using large bore catheters in large vessel occlusions. OBJECTIVE: We present our results using the ADAPT technique with distal cerebral artery occlusions. METHODS: Thirty-five patients with acute ischemic stroke with thrombus in the distal MCA, ACA, or PCA were treated with the ADAPT technique...
November 29, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27909054/identification-of-a-substrate-selective-exosite-within-the-metalloproteinase-anthrax-lethal-factor
#6
Allison B Goldberg, Eunice Cho, Chad J Miller, Hua Jane Lou, Benjamin E Turk
The metalloproteinase anthrax lethal factor (LF) is secreted by Bacillus anthracis to promote disease virulence through disruption of host signaling pathways. LF is a highly specific protease, exclusively cleaving mitogen-activated protein kinase kinases (MKKs) and rodent NACHT leucine-rich repeat and pyrin domain containing protein 1B (NLRP1B). How LF achieves such restricted substrate specificity is not understood. Previous studies have suggested the existence of an exosite interaction between LF and MKKs that promotes cleavage efficiency and specificity...
December 1, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27908759/cathepsin-nanofiber-substrates-as-potential-agent-for-targeted-drug-delivery
#7
Yael Ben-Nun, Galit Fichman, Lihi Adler-Abramovich, Boris Turk, Ehud Gazit, Galia Blum
The development of reactive drug carriers that could actively respond to biological signals is a challenging task. Different peptides can self-assemble into biocompatible nanostructures of various functionalities, including drugs carriers. Minimal building blocks, such as diphenylalanine, readily form ordered nanostructures. Here we present development of self-assembled tetra-peptides that include the diphenylalanine motif, serving as substrates of the cathepsin proteases. This is of great clinical importance as cathepsins, whose activity and expression are highly elevated in cancer and other pathologies, have been shown to serve as efficient enzymes for therapeutic release...
November 28, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27905287/hemophagocytic-syndrome-due-to-leishmania-infection-diagnosed-with-immunofluorescence-antibody-test
#8
Hakan Sarbay, Yasemin Işık Balcı, Selin Güler, Meral Türk, Mehmet Akın, Aziz Polat
Leishmaniasis is a reticuloendothelial system disease that mostly observed before the age of 5. Visceral infection causes long-standing fever, weight loss, weakness, pancytopenia, and hepatosplenomegaly. Leishmania infantum is responsible for visceral leishmaniasis (VL) in Turkey. We present a case of hemophagocytic syndrome due to Leishmania infection diagnosed with an immunofluorescence antibody test (IFAT). Leishmania amastigotes were not observed on bone marrow aspiration. We consider that IFAT is very important for parasite detection in the diagnosis of VL in children, particularly when amastigotes are not obtained on bone marrow aspiration...
September 2016: Türkiye Parazitolojii Dergisi
https://www.readbyqxmd.com/read/27898428/beneficial-effects-of-a-dietary-weight-loss-intervention-on-human-gut-microbiome-diversity-and-metabolism-are-not-sustained-during-weight-maintenance
#9
Femke-Anouska Heinsen, Daniela Fangmann, Nike Müller, Dominik M Schulte, Malte C Rühlemann, Kathrin Türk, Ute Settgast, Wolfgang Lieb, John F Baines, Stefan Schreiber, Andre Franke, Matthias Laudes
OBJECTIVE: In the present study, we examined the effect of a very low-calorie diet(VLCD)-based obesity program on human gut microbiome diversity and metabolism during weight loss and weight maintenance. METHODS: Obese subjects underwent 3 months of VLCD followed by 3 months of weight maintenance. A lean and an obese control group were included. The microbiome was characterized by performing high-throughput dual-indexed 16S rDNA amplicon sequencing. RESULTS: At baseline, a significant difference in the Firmicutes/Bacteroidetes ratio between the lean and obese individuals was observed (p = 0...
November 30, 2016: Obesity Facts
https://www.readbyqxmd.com/read/27893213/reliability-and-validity-of-data-obtained-from-alcohol-cannabis-and-gambling-populations-on-amazon-s-mechanical-turk
#10
Hyoun S Kim, David C Hodgins
Researchers recently have begun using Mechanical Turk (MTurk), an online crowdsourcing platform, to recruit addiction populations. However, whether the data obtained from substance users and gamblers on MTurk are reliable and valid is unknown. Herein, we assessed the internal and retest reliability of and concurrent and convergent validity of data obtained from addiction populations on MTurk. Current drinkers (N = 208), cannabis users (N = 200), and gamblers (N = 200) residing in the United States completed measures of alcohol, cannabis, and gambling severity, psychological constructs (e...
November 28, 2016: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/27872368/complementary-learning-systems-within-the-hippocampus-a-neural-network-modelling-approach-to-reconciling-episodic-memory-with-statistical-learning
#11
Anna C Schapiro, Nicholas B Turk-Browne, Matthew M Botvinick, Kenneth A Norman
A growing literature suggests that the hippocampus is critical for the rapid extraction of regularities from the environment. Although this fits with the known role of the hippocampus in rapid learning, it seems at odds with the idea that the hippocampus specializes in memorizing individual episodes. In particular, the Complementary Learning Systems theory argues that there is a computational trade-off between learning the specifics of individual experiences and regularities that hold across those experiences...
January 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27871583/sugammadex-given-for-rocuronium-induced-neuromuscular-blockade-in-infants-a-retrospect%C3%A4-ve-study
#12
Ozlem Ozmete, Cagla Bali, Oya Yalcin Cok, Hatice Evren Eker Turk, Nesrın Bozdogan Ozyilkan, Soner Civi, Anıs Aribogan
STUDY OBJECTIVE: To evaluate the efficacy and safety of sugammadex in reversing profound neuromuscular block induced by rocuronium in infant patients. DESIGN: Retrospective observational study. SETTING: University teaching hospital. PATIENTS: Twenty-six infants (2-12 months of age; 3-11 kg) with an American Society of Anesthesiologists classification I, II, or III who were scheduled to undergo neurosurgical procedures were included in the study...
December 2016: Journal of Clinical Anesthesia
https://www.readbyqxmd.com/read/27856826/the-influence-of-varying-cost-formats-on-preferences
#13
Charles Changchuan Jiang, Liana Fraenkel
BACKGROUND: Numerous studies have found that cost strongly influences patients' decision making. The objective of this study was to explore the impact of varying cost formats on patients' preferences. METHODS: Mechanical Turk workers completed a choice-based conjoint (CBC) survey. The CBC survey was designed to examine stated preferences for the use of second-line agents to treat diabetes across 5 attributes: route of administration, efficacy, risk of low blood sugar, frequency of checking blood sugar levels, and cost...
January 2017: Medical Decision Making: An International Journal of the Society for Medical Decision Making
https://www.readbyqxmd.com/read/27853533/no-evidence-that-a-range-of-artificial-monitoring-cues-influence-online-donations-to-charity-in-an-mturk-sample
#14
Timothy J Saunders, Alex H Taylor, Quentin D Atkinson
Monitoring cues, such as an image of a face or pair of eyes, have been found to increase prosocial behaviour in several studies. However, other studies have found little or no support for this effect. Here, we examined whether monitoring cues affect online donations to charity while manipulating the emotion displayed, the number of watchers and the cue type. We also include as statistical controls a range of likely covariates of prosocial behaviour. Using the crowdsourcing Internet marketplace, Amazon Mechanical Turk (MTurk), 1535 participants completed our survey and were given the opportunity to donate to charity while being shown an image prime...
October 2016: Royal Society Open Science
https://www.readbyqxmd.com/read/27842837/synthesis-characterization-and-modification-of-gum-arabic-microgels-for-hemocompatibility-and-antimicrobial-studies
#15
Muhammad Farooq, Selin Sagbas, Mehtap Sahiner, Mohammad Siddiq, Mustafa Turk, Nahit Aktas, Nurettin Sahiner
Gum Arabic (GA) microgels were successfully prepared via reverse micellization method with high yield (78.5±5.0%) in 5-100μm size range using divinyl sulfone (DVS) as a crosslinker. The GA microgels were degraded hydrolytically 22.8±3.5% at pH 1 in 20days, whereas no degradation was observed at pH 7.4 and pH 9 at 37°C. By using diethylenetriamine (DETA), and taurine (TA) as chemical modifying agents, GA microgels were chemically modified as GA-DETA and GA-TA, and the zeta potential values of 5.2±4.1 and -24...
January 20, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27825308/seroprevalence-of-hepatitis-e-virus-differs-in-dutch-and-first-generation-migrant-populations-in-amsterdam-the-netherlands-a-cross-sectional-study
#16
S Sadik, G G C van Rijckevorsel, M S van Rooijen, G J B Sonder, S M Bruisten
BACKGROUND: In the last decade hepatitis E virus (HEV) is increasingly recognized as a cause of acute viral hepatitis in developed countries. HEV is transmitted via the fecal-oral route. In countries like the Netherlands, HEV infection is suspected to be a zoonosis but HEV may also be introduced by migrants. We studied the seroprevalence of HEV among different migrants, mainly Moroccans and Turks, and compared this to that of the native Dutch population in Amsterdam, the Netherlands. METHODS: Data were obtained from a cross-sectional survey of the adult Amsterdam population performed in 2004; the Amsterdam Health Monitor...
November 8, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27824324/no-adverse-effects-after-radioiodine-treatment-at-3-weeks-of-pregnancy
#17
Matea Radacic-Aumiler, Iva Kraljickovic, Viktorija Edeljic-Turk, Ksenija Makar-Ausperger, Robert Likic, Iveta Simic
Radioactive iodine is used for the treatment of hyperthyroidism. Because it accumulates in the fetal thyroid, its administration during pregnancy may cause severe and potentially irreversible hypothyroidism in neonates, with consequent mental retardation, and it is contraindicated during the whole pregnancy. We present a case of a pregnant woman inadvertently treated with 1 mCi (37 MBq) of I in the earliest period of pregnancy and subsequently gave birth to a male infant without signs or symptoms of hypothyroidism or any other damage...
December 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27821118/the-intensive-care-lifeboat-a-survey-of-lay-attitudes-to-rationing-dilemmas-in-neonatal-intensive-care
#18
C Arora, J Savulescu, H Maslen, M Selgelid, D Wilkinson
BACKGROUND: Resuscitation and treatment of critically ill newborn infants is associated with relatively high mortality, morbidity and cost. Guidelines relating to resuscitation have traditionally focused on the best interests of infants. There are, however, limited resources available in the neonatal intensive care unit (NICU), meaning that difficult decisions sometimes need to be made. This study explores the intuitions of lay people (non-health professionals) regarding resource allocation decisions in the NICU...
November 8, 2016: BMC Medical Ethics
https://www.readbyqxmd.com/read/27816711/an-examination-of-the-role-of-intolerance-of-distress-and-uncertainty-in-hoarding-symptoms
#19
Brittany M Mathes, Mary E Oglesby, Nicole A Short, Amberly K Portero, Amanda M Raines, Norman B Schmidt
BACKGROUND: Hoarding disorder (HD) is a common and debilitating disorder characterized by an accumulation of and failure to discard one's possessions. The identification and examination of underlying factors that may contribute to hoarding symptoms are needed to elucidate the nature of the disorder and refine existing treatments. Two transdiagnostic vulnerability factors that have been associated with hoarding symptoms are distress intolerance (DI) and intolerance of uncertainty (IU)...
January 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27811475/participation-in-genetic-research-amazon-s-mechanical-turk-workforce-in-the-united-states-and-india
#20
Susan W Groth, Ann Dozier, Margaret Demment, Dongmei Li, I Diana Fernandez, Jack Chang, Timothy Dye
BACKGROUND: Genomic research has innumerable benefits. However, if people are unwilling to participate in genomic research, application of knowledge will be limited. This study examined the likelihood of respondents from a high- and a low- to middle-income country to participate in genetic research. METHODS: Cross-sectional data were collected using Amazon's Mechanical Turk workforce to ascertain attitudes toward participation in genetic research. Registered country of residence was either the US (n = 505) or India (n = 505)...
November 4, 2016: Public Health Genomics
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