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Çağrı Damar, Ayşe Gül Alımlı, Betül Emine Derinkuyu, Kudret Ebru Özcan, Asburçe Olgaç, Ali Murat Koç
BACKGROUND: Absent ductus venosus (ADV) is a rare condition, but it should be known that this embryonic anomaly may be detected by fetal echocardiographic or newborn ultrasound examinations. CASE REPORT: We present a baby with an ADV and an accompanying alternative porto-caval shunt between the right portal vein and inferior vena cava detected on postnatal ultrasound examination. CONCLUSIONS: Variations in the fetal umbilical or porto-systemic circulations should be detected by fetal or newborn ultrasound examinations and kept in mind before common interventions such as UV catheterizations...
2017: Polish Journal of Radiology
Francisco R V Freita, Isis C DE Lucena, Damares R Alencar, Israel J M Santos, Allysson P Pinheiro
Occurrence of Dendrocephalus brasiliensis Pesta, 1921 (Crustacea, Anostraca) in the Caras river, southern Ceara, Brazil. The specimens were collected in March and April 2014. The new occurrence extends the distribution and update area of occupancy of the species, which is characterized by a specific habitat: temporary lakes.
April 2017: Anais da Academia Brasileira de Ciências
Çağrı Damar, Ayhan Yaman, Mehmet Ali İkidağ, Esra Pekpak, Asburçe Olgaç
No abstract text is available yet for this article.
June 14, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
Mark N Stein, Joseph R Bertino, Howard L Kaufman, Tina Mayer, Rebecca Moss, Ann Silk, Nancy Chan, Jyoti Malhotra, Lorna Rodriguez, Joseph Aisner, Robert D Aiken, Bruce G Haffty, Robert S DiPaola, Tracie Saunders, Andrew Zloza, Sherri Damare, Yasmeen Beckett, Bangning Yu, Saltanat Najmi, Christian Gabel, Siobhan Dickerson, Ling Zheng, Wafik S El-Deiry, Joshua E Allen, Martin Stogniew, Wolfgang Oster, Janice M Mehnert
Purpose: ONC201 is a small-molecule selective antagonist of the G protein-coupled receptor DRD2 that is the founding member of the imipridone class of compounds. A first-in-human phase I study of ONC201 was conducted to determine its recommended phase II dose (RP2D).Experimental Design: This open-label study treated 10 patients during dose escalation with histologically confirmed advanced solid tumors. Patients received ONC201 orally once every 3 weeks, defined as one cycle, at doses from 125 to 625 mg using an accelerated titration design...
March 22, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Ismail Serifoglu, İbrahim İlker Oz, Murat Damar, Mustafa Cagtay Buyukuysal, Alptekin Tosun, Özlem Tokgöz
BACKGROUND: Nasal septal deviation may affect nasal bone growth and facial morphology. Knowledge of nasal morphologic parameters may plays an important role in planning successful rhinoplasty and septoplasty operation. The aim of our study was to evaluate the relationship between the direction and degree of nasal septal deviation with nasal bone morphology, along with factors such as age and gender. METHODS: Maxillofacial computed tomography (CT) of 250 patients with nasal septal deviation was analyzed retrospectively in this study...
February 28, 2017: Head & Face Medicine
Ugur Damar, Roman Gersner, Joshua T Johnstone, Steven Schachter, Alexander Rotenberg
Alzheimer's disease (AD) is the most frequent cause of dementia. Besides cognitive deterioration, patients with AD are prone to seizures - more than 20% of patients diagnosed with AD experience at least one unprovoked seizure and up to 7% have recurrent seizures. Although available antiepileptic drugs (AEDs) may suppress seizures in patients with AD, they may also worsen cognitive dysfunction and increase the risk of falls. On the basis of preclinical studies, we hypothesize that Huperzine A (HupA), a safe and potent acetylcholinesterase (AChE) inhibitor with potentially disease-modifying qualities in AD, may have a realistic role as an anticonvulsant in AD...
February 2017: Medical Hypotheses
Damar Tri Anggoro, Mariliis Tark-Dame, Aimee Walmsley, Rurika Oka, Mara de Sain, Maike Stam
When generating transgenic plants, one of the objectives is to achieve stable expression of the transgene. Transgene silencing can be avoided by single copy integration of the transgene. Binary systems that predominantly result in single copy integrations, such as BIBAC vectors, are also single-copy in E. coli, the organism in which the T-DNA to be delivered to the plant is assembled. Although a low-copy number is important for stable maintenance of large DNA fragments in E. coli, it hampers cloning into the vector due to a low DNA yield...
December 26, 2016: Plasmid
Alexis M Wormington, Jason Coral, Matthew M Alloy, Carmen L Delmarè, Charles M Mansfield, Stephen J Klaine, Joseph H Bisesi, Aaron P Roberts
Nano-titanium dioxide (TiO2 ) is the most widely used form of nanoparticles in commercial industry and comes in 2 main configurations: rutile and anatase. Rutile TiO2 is used in ultraviolet (UV) screening applications, whereas anatase TiO2 crystals have a surface defect that makes them photoreactive. There are numerous reports in the literature of photo-induced toxicity to aquatic organisms following coexposure to anatase nano-TiO2 and UV. All natural freshwater contains varying amounts of natural organic matter (NOM), which can drive UV attenuation and quench reactive oxygen species (ROS) in aquatic ecosystems...
June 2017: Environmental Toxicology and Chemistry
Saptawati Bardosono, Damar Prasmusinto, Diah R Hadiati, Bangun T Purwaka, Clementine Morin, Rizki Pohan, Diana Sunardi, Dian N Chandra, Isabelle Guelinckx
During pregnancy and lactation, the adequate intake (AI) for total water intake is increased. This cross-sectional survey aimed to assess Total Fluid Intake (TFI; sum of drinking water and all other fluids) of 300 pregnant and 300 breastfeeding women in Indonesia. A seven-day fluid specific record was used to assess TFI. Mean TFI of pregnant and breastfeeding women were 2332 ± 746 mL/day and 2525 ± 843 mL/day, respectively. No significant difference in TFI between pregnancy trimesters was observed, while TFI of women breastfeeding for 12-24 months postpartum (2427 ± 955 mL/day) was lower than that of the two other groups (0-5 months: 2607 ± 754 mL/day; 6-11 months: 2538 ± 807 mL/day, respectively)...
November 22, 2016: Nutrients
Sigrid Heuer, Roberto Gaxiola, Rhiannon Schilling, Luis Herrera-Estrella, Damar López-Arredondo, Matthias Wissuwa, Emmanuel Delhaize, Hatem Rouached
Phosphorus (P) is one of the essential nutrients for plants, and is indispensable for plant growth and development. P deficiency severely limits crop yield, and regular fertilizer applications are required to obtain high yields and to prevent soil degradation. To access P from the soil, plants have evolved high- and low-affinity Pi transporters and the ability to induce root architectural changes to forage P. Also, adjustments of numerous cellular processes are triggered by the P starvation response, a tightly regulated process in plants...
June 2017: Plant Journal: for Cell and Molecular Biology
Sultan Şevik Eliçora, Duygu Erdem, Aykut Erdem Dinç, Murat Damar, Sultan Bişkin
To investigate the effects of surgery type [intact canal wall (ICW) or canal wall down (CWD) mastoidectomy] and different ossiculoplasty materials on hearing outcome in single-staged cholesteatoma surgery. A retrospective case-control study. A total of 116 cases (97 adults, 29 children) underwent surgery, including ossiculoplasty, between 2012 and 2015 for cholesteatoma. Patients who had undergone surgery for the first time, and whose grafts were successful, were included in the study. Patients with adhesive otitis media, unsuccessful grafts, revision and recurrent cases, radical mastoidectomy, and craniofacial anomalies were excluded...
February 2017: European Archives of Oto-rhino-laryngology
Olivia Sanyal, Varsha Laxman Shinde, Ram Murti Meena, Samir Damare, Belle Damodara Shenoy
Tarballs, the remnants of crude oil which change into semi-solid phase due to various weathering processes in the sea, are rich in hydrocarbons, including toxic and almost non-degradable hydrocarbons. Certain microorganisms such as fungi are known to utilize hydrocarbons present in tarballs as sole source of carbon for nutrition. Previous studies have reported 53 fungal taxa associated with tarballs. There is apparently no gene sequence-data available for the published taxa so as to verify the fungal identification using modern taxonomic tools...
December 15, 2016: Marine Pollution Bulletin
Nurullah Çelik, Peyami Cinaz, Aysun Bideci, Betül Derinkuyu, Hamdi Cihan Emeksiz, Esra Döğer, Çağrı Damar, Özge Yüce, Orhun Çamurdan
BACKGROUND: The aim of this study was to investigate the early signs of atherosclerosis and to evaluate serum endoglin and obestatin levels as predictors of subclinical atherosclerosis in obese children. METHODS: A total of 95 children (60 obese and 35 controls) aged 10-18 years were included in the study. Their endoglin and obestatin levels and biochemical parameters were measured. The carotid intima media thickness (cIMT) and brachial artery flow-mediated dilatation (FMD) responses were evaluated...
October 1, 2016: Journal of Pediatric Endocrinology & Metabolism: JPEM
Mustafa Zungur, Ilker Gul, Ahmet Tastan, Ertan Damar, Talat Tavli
BACKGROUND/AIMS: The Mehran risk score (MS) was adopted to predict the development of contrast-induced nephropathy (CIN) and includes clinical and procedural variables. In this study, we aimed to evaluate the value of MS in the prediction of CIN development after transcatheter aortic valve implantation (TAVI). METHODS: Ninety-three patients (47 females; mean age, 77.2 ± 7.6 years) who underwent aortic valve replacement with TAVI for severe aortic stenosis in our center between June 2013 and November 2014 were included in the study...
August 2016: Cardiorenal Medicine
Murat Damar, Aykut Erdem Dinç, Duygu Erdem, Utku Aydil, Yusuf Kizil, Fakih Cihat Eravcı, Sultan Bişkin, Sultan Şevik Eliçora, Hüseyin Işik
OBJECTIVE: To assess pretreatment levels in the counts and percentages of leukocytes and the neutrophil-lymphocyte ratio (NLR) in benign and malignant salivary gland tumors (SGTs) while investigating whether NLR is an inflammatory marker for distinguishing low- from high-grade parotid gland tumors. STUDY DESIGN: Case series with chart review. SETTING: Tertiary referral center. SUBJECTS AND METHODS: This study was performed on 182 patients with SGTs (age range: 16-87 years; 93 male and 89 female) who were treated between January 2010 and May 2015...
December 2016: Otolaryngology—Head and Neck Surgery
Baris Kaya, Zeki Damarer, Korkut Daglar, Orhan Unal, Amr Soliman, Onur Guralp
PURPOSE: To evaluate the success rates and subsequent fertility outcomes of internal iliac artery ligation (IIAL) in uterine atony (primary ligated and secondary added to other uterus sparing techniques), retroperitoneal hematoma, and placenta adherent abnormalities. MATERIAL AND METHODS: Fifty two women who underwent IIAL for different causes of postpartum hemorrhage were retrospectively evaluated. RESULTS: Among 26 women with intractable uterine atony, 12 had primary, and 14 secondary IIAL, due to ongoing bleeding following the B-Lynch suture or the Bakri balloon tamponade...
June 2017: Journal of Maternal-fetal & Neonatal Medicine
Faik Kose, Zafer Turkyilmaz, Kaan Sonmez, Ramazan Karabulut, Aylar Poyraz, Ozlem Gulbahar, Arzu Aral, Cagri Damar, Cem Kaya, Abdullah Can Basaklar
BACKGROUND: In this study, it was aimed to determine the effects of alfuzosin on experimentally generated unilateral partial ureteropelvic junction obstruction (UPO) in rats. MATERIALS AND METHODS: Thirty Long-Evans rats were randomly allocated into five groups. In control group (C), nothing was performed; in group Sham (S) only laparotomy was done; in Alfuzosin group (A) only alfuzosin was administered for two weeks (10 mg/kg/day p.o.) without any surgery; in UPO group, unilateral UP junction obstruction was produced; and in the Group UPT (ureteropelvic obstruction + treatment), alfuzosin was administered for two weeks (10 mg/kg/day p...
September 2016: Renal Failure
David W Greenfield, Susan L Jewett
Two new species of dwarfgobies are described, Eviota asymbasia from the Sulu Sea, Philippine Islands, south to Java and west to Damar, and E. bipunctata occurring from the Indian Ocean eastward into the western Pacific Ocean. Eviota asymbasia lacks the IT pore of the cephalic sensory-pore system and usually also the POP, has a dorsal/anal-fin formula of 8/8, has some pectoral-fin rays branched and usually 15 rays, two spots on the pectoral-fin base, no dark spot over the preural centrum, first dorsal fin may be filamentous, six ventral postanal spots, and the male genital papilla is not fimbriate...
June 13, 2016: Zootaxa
Serdar Baygeldi, Oktay Karakose, Kazım Caglar Özcelik, Hüseyin Pülat, Sedat Damar, Hüseyin Eken, İsmail Zihni, Alpaslan Fedai Çalta, Bilsel Baç
Background and Aim. The aim of this study was to investigate the effects of demographic characteristics, biochemical parameters, amount of blood transfusion, and trauma scores on morbidity in patients with solid organ injury following trauma. Material and Method. One hundred nine patients with solid organ injury due to abdominal trauma during January 2005 and October 2015 were examined retrospectively in the General Surgery Department of Dicle University Medical Faculty. Patients' age, gender, trauma interval time, vital status (heart rate, arterial tension, and respiratory rate), hematocrit (HCT) value, serum area aminotransferase (ALT) and aspartate aminotransferase (AST) values, presence of free abdominal fluid in USG, trauma mechanism, extra-abdominal system injuries, injured solid organs and their number, degree of injury in abdominal CT, number of blood transfusions, duration of hospital stay, time of operation (for those undergoing operation), trauma scores (ISS, RTS, Glasgow coma scale, and TRISS), and causes of morbidity and mortality were examined...
2016: Disease Markers
Simon A van der Wulp, Ario Damar, Norbert Ladwig, Karl-J Hesse
The present application of numerical modelling techniques provides an overview of river discharges, nutrient flux and nutrient dispersal in Jakarta Bay. A hydrological model simulated river discharges with a total of 90 to 377m(3)s(-1) entering Jakarta Bay. Daily total nitrogen and total phosphorus loads ranged from 40 to 174tons and 14 to 60tons, respectively. Flow model results indicate that nutrient gradients are subject to turbulent mixing by tides and advective transport through circulation driven by wind, barotropic and baroclinic pressure gradients...
September 30, 2016: Marine Pollution Bulletin
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