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HPV vaccines and adverse effects

Vijay Shankar Balakrishnan
No abstract text is available yet for this article.
April 6, 2017: Lancet Oncology
Joseph Niyibizi, Nadège Zanré, Marie-Hélène Mayrand, Helen Trottier
BACKGROUND: Human papillomavirus (HPV) is the most prevalent genital infection, especially in young women of reproductive age. In vitro and animal model experiments provide compelling evidence of the harmful effect of HPV on pregnancy outcomes, but results from epidemiologic studies are inconclusive. We aim to determine the strength of the relationship between adverse pregnancy outcomes (APO) and HPV infection and assess its consistency across studies, by systematically reviewing the literature...
March 11, 2017: Systematic Reviews
Anna J Nichols, Amber Heyna Allen, Shahjahan Shareef, Evangelos V Badiavas, Robert S Kirsner, Tim Ioannides
Importance: Keratinocyte carcinomas (KCs), consisting of squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs), are the most common human malignant neoplasms. Several risk factors have been implicated in KC development. For some SCCs, particularly those in immunocompromised patients, human papillomavirus (HPV) may be an important factor. Objective: To determine whether quadrivalent HPV vaccination would affect the development of KCs in immunocompetent patients with a history of multiple KCs...
February 8, 2017: JAMA Dermatology
Rengaswamy Sankaranarayanan, Neerja Bhatla, Partha Basu
This review addresses the effectiveness and safety of human papillomavirus (HPV) vaccines, the current status of its introduction in the National Immunization Programmes (NIPs) and its relevance to India, which contributes a fifth of the global burden of cervical cancer. The vast literature on efficacy, acceptability and safety of HPV vaccination and its impact after population level introduction was reviewed and discussed. The efficacy of HPV vaccines in preventing high-grade precancerous lesions caused by vaccine-targeted HPV infections was 90 per cent or higher in HPV naοve women in randomized clinical trials...
August 2016: Indian Journal of Medical Research
Nobuyoshi Ozawa, Kiyoshi Ito, Toru Tase, Hirohito Metoki, Nobuo Yaegashi
Prevention of cervical cancer has been unsuccessful in Japan because of low rates of cancer screening and vaccination. The Vaccine Adverse Review Committee of the Japanese Government investigated 2,475 adverse events and reported 617 (6.9/100,000) severe cases and 176 (2.0/100,000) cases with chronic pain. The proactive recommendation for human papillomavirus (HPV) vaccination has been suspended since June 2013. In this study, we examined vaccination rate and incidence of abnormal cervical cytology in women aged 20 to 24 years attending cancer screening in Miyagi...
2016: Tohoku Journal of Experimental Medicine
Asami Yagi, Yutaka Ueda, Tomomi Egawa-Takata, Yusuke Tanaka, Akiko Morimoto, Yoshito Terai, Masahide Ohmichi, Tomoyuki Ichimura, Toshiyuki Sumi, Hiromi Murata, Hidetaka Okada, Hidekatsu Nakai, Masaki Mandai, Kiyoshi Yoshino, Tadashi Kimura, Junko Saito, Risa Kudoh, Masayuki Sekine, Takayuki Enomoto, Kei Hirai, Yorihiko Horikoshi, Tetsu Takagi, Kentaro Shimura
BACKGROUND: In Japan, new HPV immunizations have dropped dramatically after repeated adverse media reports and a June 2013 temporary suspension of the government's recommendation for the vaccine. The aim of the present study was to develop an efficient strategy to improve HPV immunization coverage across Japan. METHODS: We conducted an internet survey in Japan of mothers of 12-16 year-old girls who were unvaccinated as of May, 2015. The goal was to gather behavioral information from the mothers to develop a strategy for improving Japanese HPV immunization coverage...
2016: BMC Public Health
Cibelle Carneiro Farias, Dkaion Vilela Jesus, Hendel Santana Moraes, Ingrid Ferreira Buttenbender, Isabella Seixas Martins, Mayara Gabrielle Souto, Paulo Henrique Brasil Hass Gonçalves Filho, Randielly Mendonça Costa, Sarah de Oliveira Silva, Thais Suelen Israel Ferreira, Valéria Vieira da Silva Coutinho, Helvia Rochelle Tavora Minotto, Allex Jardim Fonseca
BACKGROUND: To evaluate the HPV vaccination coverage in Boa Vista, Roraima (Brazil) and to identify personal and socioeconomic factors related to non-compliance to HPV vaccination. METHODS: A school-based, cross-sectional study was conducted by distributing a self-administered questionnaire to the parents or guardians of pre-adolescent girls. The questionnaire addressed compliance to, knowledge about and perception of HPV and the HPV vaccine. Between July and November 2015, 13 private and public schools were visited based on a random cluster sampling method...
2016: BMC Health Services Research
Severin Kabakama, Katherine E Gallagher, Natasha Howard, Sandra Mounier-Jack, Helen E D Burchett, Ulla K Griffiths, Marta Feletto, D Scott LaMontagne, Deborah Watson-Jones
BACKGROUND: Social mobilisation during new vaccine introductions encourages acceptance, uptake and adherence to multi-dose schedules. Effective communication is considered especially important for human papillomavirus (HPV) vaccine, which targets girls of an often-novel age group. This study synthesised experiences and lessons learnt around social mobilisation, consent, and acceptability during 55 HPV vaccine demonstration projects and 8 national programmes in 37 low and middle-income countries (LMICs) between January 2007 and January 2015...
2016: BMC Public Health
Takahiro Ushida, Masahiko Shibata, Masaki Kitahara, Shoji Yabuki, Masahiko Sumitani, Takanori Murakami, Masako Iseki, Masako Hosoi, Hiroaki Shiokawa, Tomoko Tetsunaga, Hiroyuki Nishie, Sei Fukui, Motohiro Kawasaki, Sinsuke Inoue, Makoto Nishihara, Shuichi Aono, Tatunori Ikemoto, Takashi Kawai, Young-Chang Arai
Background. Two prophylactic papillomavirus (HPV) vaccines have been available for primary prevention of cervical cancer. Although serious adverse effects (AE) were rare, more than 230 women have been suffering from severe AEs such as persistent pain and headache in Japan. Our research group started to treat adolescent females suffering from the AEs. Objective. To survey the characteristics of and the effects of cognitive behavioral therapy on adolescent female suffering from the AEs in Japanese multidisciplinary pain centers...
2016: Pain Research & Management: the Journal of the Canadian Pain Society
A F Nicol, C V Andrade, F B Russomano, L L S Rodrigues, N S Oliveira, D W Provance
Controversy still exists over whether the benefits of the available HPV vaccines outweigh the risks and this has suppressed uptake of the HPV vaccines in comparison to other vaccines. Concerns about HPV vaccine safety have led some physicians, healthcare officials and parents to withhold the recommended vaccination from the target population. The most common reason for not administering the prophylactic HPV vaccines are concerns over adverse effects. The aim of this review is the assessment of peer-reviewed scientific data related to measurable outcomes from the use of HPV vaccines throughout the world with focused attention on the potential adverse effects...
2016: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
R L Cameron, S Ahmed, K G J Pollock
BACKGROUND: Human papillomavirus (HPV) vaccines are currently utilised globally in national immunisation programmes. While evidence from clinical trials and epidemiological studies suggest that the HPV vaccines are both effective and safe, concerns about the safety of the vaccine and scientifically unproven associations with severe adverse events following immunisation have led to dramatic decreases in vaccine uptake in Japan and acceptance issues in other countries. AIM: In Scotland, we utilised hospital admissions data to assess the impact of the HPV immunisation programme on the incidence of 60 diagnoses between 2004 and 2014 in both girls and boys; with boys acting as a comparator group...
April 2016: Internal Medicine Journal
Holly B Fontenot, Vanessa Domush, Gregory D Zimet
PURPOSE: The purpose of the study was to explore parents' attitudes and beliefs about the nine-valent human papillomavirus vaccine (HPV9). METHODS: Online focus groups were conducted in January, 2015. The U.S. national sample of parents was recruited to four groups: (1) two groups of parents of HPV unvaccinated daughters aged 9-12 years and (2) two groups of parents of vaccinated daughters aged 11-17 years. RESULTS: Participants were 43 parents of vaccinated daughters and 38 parents of unvaccinated daughters...
December 2015: Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine
William W Greenfield, Shawna L Stratton, Rebecca S Myrick, Rita Vaughn, Lisa M Donnalley, Hannah N Coleman, Maria Mercado, Andrea M Moerman-Herzog, Horace J Spencer, Nancy R Andrews-Collins, Wilbur C Hitt, Gordon M Low, Nirvana A Manning, Samantha S McKelvey, Dora Smith, Michael V Smith, Amy M Phillips, C Matthew Quick, Susanne K Jeffus, Laura F Hutchins, Mayumi Nakagawa
PURPOSE: Non-surgical treatments for cervical intraepithelial neoplasia 2/3 (CIN2/3) are needed as surgical treatments have been shown to double preterm delivery rate. The goal of this study was to demonstrate safety of a human papillomavirus (HPV) therapeutic vaccine called PepCan, which consists of four current good-manufacturing production-grade peptides covering the HPV type 16 E6 protein and Candida skin test reagent as a novel adjuvant. PATIENTS AND METHODS: The study was a single-arm, single-institution, dose-escalation phase I clinical trial, and the patients (n = 24) were women with biopsy-proven CIN2/3...
October 2015: Oncoimmunology
Alcina F Nicol, Cecilia V de Andrade, Fabio B Russomano, Luana S L Rodrigues, Nathalia S Oliveira, David William Provance, Gerard J Nuovo
The discovery of the human papillomavirus (HPV) vaccine illustrates the power of in situ-based pathologic analysis in better understanding and curing diseases. The 2 available HPV vaccines have markedly reduced the incidence of cervical intraepithelial neoplasias, genital warts, and cervical cancer throughout the world. Concerns about HPV vaccine safety have led some physicians, health care officials, and parents to refuse providing the recommended vaccination to the target population. The aims of the study were to discuss the discovery of HPV vaccine and review scientific data related to measurable outcomes from the use of HPV vaccines...
December 2015: Annals of Diagnostic Pathology
Katlyn Scott, Mary Lou Batty
The human papillomavirus (HPV) infects approximately 550,000 Canadians annually. Cancers of the cervix, mouth, anus, throat and neck are caused by various strains of the virus. The virus also causes genital warts. The disease and economic burden of HPV is high. Primary prevention through vaccine administration prior to onset of sexual activity is evidenced as best practice. Two vaccines are available, Gardasil and Cervarix. Consistent with global practices in developed countries, these vaccines are currently publicly funded for females and provided in school-based clinics in all provinces and territories in Canada...
February 2016: Journal of Community Health
Britain Baker, Luísa Eça Guimarães, Lucija Tomljenovic, Nancy Agmon-Levin, Yehuda Shoenfeld
INTRODUCTION: With the safety of human papilloma virus vaccine (HPVv) being questioned, this article aims to assess the risks and benefits of the commercially available HPVv. Within the last decade, two vaccines (Gardasil and Cervarix) have been put on the market to prevent infection with the most oncogenic HPV subtypes. Both vaccines contain aluminum adjuvants that are meant to cause a hyper stimulated immune response to prevent HPV infection. AREAS COVERED: The purpose of this paper is to consider the safety of these two vaccines based on the data from the U...
2015: Expert Opinion on Drug Safety
Tomomi Egawa-Takata, Yutaka Ueda, Akiko Morimoto, Yusuke Tanaka, Shinya Matsuzaki, Eiji Kobayashi, Kiyoshi Yoshino, Masayuki Sekine, Takayuki Enomoto, Tadashi Kimura
BACKGROUND: Most adolescents in Japan have recently been refraining from receiving the human papillomavirus (HPV) vaccine, following media reports of adverse medical events surrounding the vaccination and suspension of the Japanese governmental recommendation. We have previously reported that HPV vaccination of young girls is heavily influenced by guidance from their physicians concerning the vaccine and by the knowledge and attitude of the girls' mothers towards cervical cancer. However, it has been unclear as to how the obstetricians and gynecologists were themselves affected by the negative media reports...
February 2016: International Journal of Clinical Oncology
Miriam Nakalembe, Florence M Mirembe, Cecily Banura
Currently, there is limited data on the immunogenicity and efficacy of human papillomavirus vaccines in Low and Middle income countries (LMIC). The review aims to summarize the current status from published HPV vaccine safety, immunogenicity and efficacy studies in low and middle income countries (LMIC). Electronic databases (PubMed/MEDLINE and HINARI) were searched for peer reviewed English language articles on HPV vaccination in LMIC that have so far been published from 1st January 2006 up to 30th January 2015...
2015: Infectious Agents and Cancer
(no author information available yet)
The efficacy of HPV vaccines has still not been adequately determined as of late 2014, apart from a preventive effect on precancerous cervical lesions in the years following vaccination.This makes it all the more important to thoroughly assess the adverse effects of HPV vaccination.
May 2015: Prescrire International
Manuel Martínez-Lavín
Vaccination has been one of the most effective public health measures in the history of medicine. However, seemingly inexplicit adverse reactions have been described after the injection of the newer vaccines vs. human papillomavirus (HPV). The symptoms more often reported are chronic pain with paresthesias, headaches, fatigue, and orthostatic intolerance. Adverse reactions appear to be more frequent after HPV vaccination when compared to other type of immunizations. Different isolated cases and small series have described the development of complex regional pain syndrome (CRPS), postural orthostatic tachycardia syndrome (POTS), and fibromyalgia after HPV vaccination...
July 2015: Clinical Rheumatology
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