Guan-Min Ho, Jasmin Rast, Li-Chun Hsieh, Arne Böttcher, Stefan Meng, Lukas F Reissig, Chieh-Han Tzou, Markus Maria Hess, Berit Schneider-Stickler, Jack Jiang, Yin-Ta Lai, Sheng-Po Yuan, Ying-Piao Wang, Stefan H Geyer, Wolfgang J Weninger
OBJECTIVE: To evaluate the concept and efficacy of an adjustable implant (Prototype SH30: porcine implant and APrevent® VOIS: human concept) for treatment of unilateral vocal fold paralysis (UVFP) via in vivo mini-pig studies, human computed tomographic (CT) and magnetic resonance (MR) image analysis, ex-vivo aerodynamic and acoustic analysis. METHODS: Feasibility testing and prototype implantation were performed using in-vivo UVFP porcine model ( n = 8), followed by a dimensional finding study using CT and MR scans of larynges ( n = 75) for modification of the implant prototypes...
June 2023: Laryngoscope Investigative Otolaryngology