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Stratification epidemiology

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https://www.readbyqxmd.com/read/28931789/metabolic-syndrome-over-4-years-before-the-onset-of-cardiovascular-disease%C3%A3-nested-case-control-study
#1
Huanhuan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Akiko Nanri, Maki Konishi, Hiroko Okazaki, Keisuke Kuwahara, Ai Hori, Chihiro Nishiura, Ikuko Kashino, Teppei Imai, Akiko Nishihara, Shamima Akter, Toshiaki Miyamoto, Naoko Sasaki, Takayuki Ogasawara, Akihiko Uehara, Makoto Yamamoto, Taizo Murakami, Makiko Shimizu, Masafumi Eguchi, Takeshi Kochi, Satsue Nagahama, Kentaro Tomita, Isamu Kabe, Tetsuya Mizoue, Tomofumi Sone, Seitaro Dohi
BACKGROUND: We investigated the risk of cardiovascular disease (CVD) with duration of metabolic syndrome (MetS) for the past 4 years before the CVD event.Methods and Results:We performed a nested case-control study within the Japan Epidemiology Collaboration on Occupational Health Study. A total of 139 registered cases of CVD and 561 self-reported cases of CVD were identified and matched individually on age, sex, and worksite with 695 and 2,803 controls, respectively. MetS was defined by the Joint Interim Statement definition...
September 21, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28928865/refining-the-american-joint-committee-on-cancer-staging-scheme-for-resectable-pancreatic-ductal-adenocarcinoma-using-recursive-partitioning-analysis
#2
Yiquan Jiang, Yanhong Su, Yutong Chen, Zhiyong Li
Purpose: It remains unclear whether the recently proposed 8(th) edition of the American Joint Committee on Cancer (AJCC) staging scheme for pancreatic ductal adenocarcinoma (PDAC) outperforms the 7(th) edition. We assessed the prognostic performance of both these schemes and performed recursive partitioning analysis (RPA) to objectively regroup the 7(th) and 8(th) AJCC stages and derive a refined staging scheme. Methods: We examined 8542 patients with resectable PDAC from the 2004-2012 Surveillance, Epidemiology, and End Results database...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28928611/brugada-syndrome-in-children-stepping-into-unchartered-territory
#3
REVIEW
Shashank P Behere, Steven N Weindling
Brugada syndrome (BrS) is an autosomal dominant inherited channelopathy. It is associated with a typical pattern of ST-segment elevation in the precordial leads V1-V3 and potentially lethal ventricular arrhythmias in otherwise healthy patients. It is frequently seen in young Asian males, in whom it has previously been described as sudden unexplained nocturnal death syndrome. Although it typically presents in young adults, it is also known to present in children and infants, especially in the presence of fever...
September 2017: Annals of Pediatric Cardiology
https://www.readbyqxmd.com/read/28927948/survival-trends-in-patients-with-tracheal-carcinoma-from-1973-to-2011
#4
Surbhi Agrawal, Christopher Jackson, Karel-Bart Celie, Chetan Dodhia, Daphne Monie, Jose Monzon, Theodor Kaufman, Nicholas J Hellenthal
PURPOSE: The prognosis for primary tracheal cancer is dismal. We investigated whether there has been improvement in survival in tracheal cancer patients and how treatment modality affected overall and cancer-specific survival. MATERIALS AND METHODS: Using the Surveillance, Epidemiology, and End Results database, 1144 patients with tracheal cancer were identified between 1973 and 2011. Patients were stratified by age group, gender, race, tumor histology, and treatment modality...
August 26, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28918344/accesses-for-alcohol-intoxication-to-the-emergency-department-and-the-risk-of-re-hospitalization-an-observational-retrospective-study
#5
Maurizio Baldassarre, Fabio Caputo, Raimondo Maria Pavarin, Matteo Massimo Bossi, Maria Elena Bonavita, Paolo Caraceni, Alice Grignaschi, Mimosa Balloni, Mario Cavazza, Mauro Bernardi, Marco Domenicali
BACKGROUND: Alcohol use disorders (AUD) are a frequent cause of admission to emergency departments (EDs) for acute alcohol intoxication (AAI). Patients with AUD present a higher risk of readmission to EDs for AAI than the general population, however, the distinction between sporadic AAI and AAI in the context of AUD in the ED setting is difficult. AIMS: To analyze the epidemiological characteristics of patients admitted to EDs because of AAI and to identify factors associated with repeated admissions in order to develop a risk stratification system for patients with AUD based on objective data that can be easily applied in an ED setting...
September 1, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28895660/epidemiology-molecular-classification-and-who-grading-of-ependymoma
#6
Jens-Martin Hübner, Marcel Kool, Stefan M Pfister, Kristian W Pajtler
Ependymoma can arise throughout all compartments of the central nervous system with prevalence for intracranial and spinal location in children and adults, respectively. The current histopathology based WHO grading system distinguishes grade I, II 'classic', and III 'anaplastic' ependymoma. However, analysis of multiple cohorts of intracranial ependymoma demonstrate a wide variance in the utility of the grade II versus grade III distinction as a prognostic marker that may additionally be confounded by the anatomic compartment...
September 8, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28893833/anticoagulation-for-nonvalvular-atrial-fibrillation-influence-of-epidemiologic-trends-and-clinical-practice-patterns-on-risk-stratification-and-net-clinical-benefit
#7
Richard W Asinger, Gautam R Shroff, Mengistu A Simegn, Charles A Herzog
No abstract text is available yet for this article.
September 2017: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/28881475/the-cancer-of-the-bladder-risk-assessment-cobra-score-estimating-mortality-after-radical-cystectomy
#8
Christopher J Welty, Thomas H Sanford, Jonathan L Wright, Peter R Carroll, Matthew R Cooperberg, Maxwell V Meng, Sima P Porten
BACKGROUND: Risk stratification of patients with urothelial carcinoma of the bladder (UCB) after cystectomy has important clinical and research implications. The authors assessed the relative effect of tumor stage and lymph node status on cancer-specific survival (CSS) after cystectomy and developed a simplified risk-assessment tool. METHODS: In total, 14,828 patients who underwent cystectomy with lymph node dissection for UCB were identified from the Surveillance, Epidemiology, and End Results database (1988-2011)...
September 7, 2017: Cancer
https://www.readbyqxmd.com/read/28860731/egfrs-from-asian-modified-ckd-epi-and-chinese-modified-ckd-epi-equations-were-associated-better-with-hypertensive-target-organ-damage-in-the-community-dwelling-elderly-chinese-the-northern-shanghai-study
#9
Hongwei Ji, Han Zhang, Jing Xiong, Shikai Yu, Chen Chi, Bin Bai, Jue Li, Jacques Blacher, Yi Zhang, Yawei Xu
BACKGROUND: With increasing age, estimated glomerular filtration rate (eGFR) decline is a frequent manifestation and is strongly associated with other preclinical target organ damage (TOD). In literature, many equations exist in assessing patients' eGFR. However, these equations were mainly derived and validated in the population from Western countries, which equation should be used for risk stratification in the Chinese population remains unclear, as well as their comparison. Considering that TOD is a good marker for risk stratification in the elderly, in this analysis, we aimed to investigate whether the recent eGFR equations derived from Asian and Chinese are better associated with preclinical TOD than the other equations in elderly Chinese...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28856437/diagnosis-and-empirical-treatment-of-fever-of-unknown-origin-fuo-in-adult-neutropenic-patients-guidelines-of-the-infectious-diseases-working-party-agiho-of-the-german-society-of-hematology-and-medical-oncology-dgho
#10
REVIEW
W J Heinz, D Buchheidt, M Christopeit, M von Lilienfeld-Toal, O A Cornely, H Einsele, M Karthaus, H Link, R Mahlberg, S Neumann, H Ostermann, O Penack, M Ruhnke, M Sandherr, X Schiel, J J Vehreschild, F Weissinger, G Maschmeyer
Fever may be the only clinical symptom at the onset of infection in neutropenic cancer patients undergoing myelosuppressive chemotherapy. A prompt and evidence-based diagnostic and therapeutic approach is mandatory. A systematic search of current literature was conducted, including only full papers and excluding allogeneic hematopoietic stem cell transplant recipients. Recommendations for diagnosis and therapy were developed by an expert panel and approved after plenary discussion by the AGIHO. Randomized clinical trials were mainly available for therapeutic decisions, and new diagnostic procedures have been introduced into clinical practice in the past decade...
August 30, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28844116/cardiometabolic-disorders-in-psoriatic-disease
#11
REVIEW
Curtis Sobchak, Lihi Eder
PURPOSE OF REVIEW: Patients with psoriasis and psoriatic arthritis, collectively termed psoriatic disease (PsD), are at an increased risk of developing cardiovascular diseases (CVD). The purpose if this manuscript is to review recent evidence about the epidemiology and underlying mechanisms of CVD in psoriatic patients and approaches to improve the management of these comorbidities. RECENT FINDINGS: Studies have shown that CVD risk is independent of traditional cardiovascular risk factors and is related to the systemic inflammatory nature of PsD...
August 26, 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28838409/epidemiology-natural-history-and-risk-stratification-of-crohn-s-disease
#12
REVIEW
Satimai Aniwan, Sang Hyoung Park, Edward V Loftus
Crohn's disease (CD) is a chronic condition that can result in significant morbidity and disability. By studying the association between demographics and initial clinical features and subsequent natural history, one may be able to stratify patients by their risks of clinical relapse, hospitalization, and surgery. Understanding the potential environmental risk factors and natural history of CD in a given patient guides the physician when counseling the patient and selecting a treatment strategy. In this review, updated data regarding the incidence and prevalence of CD, important environmental risk factors, natural history of the disease, and important prognostic factors are discussed...
September 2017: Gastroenterology Clinics of North America
https://www.readbyqxmd.com/read/28832659/racial-disparities-in-cancer-related-survival-in-patients-with-squamous-cell-carcinoma-of-the-esophagus-in-the-us-between-1973-and-2013
#13
Alice Kim, Peter Ashman, Melissa Ward-Peterson, Juan Manuel Lozano, Noël C Barengo
BACKGROUND: Esophageal cancer makes up approximately 1% of all diagnosed cancers in the US. There is a persistent disparity in incidence and cancer-related mortality rates among different races for esophageal squamous cell carcinoma (SCC). Most previous studies investigated racial disparities between black and white patients, occasionally examining disparities for Hispanic patients. Studies including Asians/Pacific Islanders (API) as a subgroup are rare. Our objective was to determine whether there is an association between race and cancer-related survival in patients with esophageal SCC...
2017: PloS One
https://www.readbyqxmd.com/read/28819775/sublobar-resection-versus-lobectomy-in-patients-aged-%C3%A2-35%C3%A2-years-with-stage-ia-non-small-cell-lung-cancer-a-seer-database-analysis
#14
Chang Gu, Rui Wang, Xufeng Pan, Qingyuan Huang, Yangyang Zhang, Jun Yang, Jianxin Shi
PURPOSE: Sublobar resection has been increasingly adopted in elderly patients with stage IA non-small cell lung cancer (NSCLC), but the equivalency of sublobar resection versus lobectomy among young patients with stage IA NSCLC is unknown. METHODS: Using the Surveillance, Epidemiology, and End Results (SEER) registry, we identified patients aged ≤35 years who were diagnosed between 2004 and 2013 with pathological stage IA NSCLC and treated with sublobar resection or lobectomy...
August 17, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28800668/-epidemiology-risk-factors-and-risk-stratification-of-venous-thromboembolism-in-pregnancy-and-the-puerperium
#15
Panagiotis Tsikouras, Georg-Friedrich von Tempelhoff, Werner Rath
Venous thromboembolism (VTE) remains a leading cause of direct maternal deaths in the developed countries. The incidence of VTE has increased significantly during the past two decades. The absolute risk of VTE is estimated 0.6-2.2 per 1000 deliveries. Compared with age-matched non-pregnant women, the daily risk of VTE is increased 7- to 10-fold for antepartum VTE, but it is 15- to 35-fold for postpartum VTE. The incidence of pulmonary embolism (PE) during the first 6 weeks postpartum is nearly 15-fold higher compared to the incidence in pregnancy, and remains significantly increased up to 12 weeks postpartum...
August 2017: Zeitschrift Für Geburtshilfe und Neonatologie
https://www.readbyqxmd.com/read/28794391/labor-factor-barriers-to-seeking-medical-services-among-metropolitan-workers-a-cross-sectional-analysis-by-sex-using-the-j-shine-study
#16
Liying Pei, Satoshi Toyokawa, Yasuki Kobayashi
OBJECTIVES: There is limited evidence on the relationship between labor factors and the decision to refrain from seeking medical services. This study aimed to examine how labor factors are related to medical service access among male and female workers in Tokyo and surrounding areas. METHODS: We used data from 4,385 respondents to the survey in the Japanese Study on Stratification, Health, Income, and Neighborhood (J-SHINE), an ongoing epidemiologic household panel study...
August 8, 2017: Journal of Occupational Health
https://www.readbyqxmd.com/read/28776604/the-role-of-diet-physical-activity-body-fatness-and-breastfeeding-in-breast-cancer-in-young-women-epidemiological-evidence
#17
I Isabelle Romieu, A Amadou, V Chajes
The incidence of breast cancer (BC) is rising worldwide, with an increase in aggressive neoplasias in young women. Traditionally, BC in young women has been thought to be etiologically driven, primarily by genetic/hereditary factors. However, these factors explain only a small proportion of BCs, pointing to a role of the environment. Suspected factors responsible for this increase include lifestyle changes, notably alcohol consumption, diet with high intake of refined carbohydrates and saturated fat and low intake of polyunsaturated fatty acids (PUFA), fiber and vitamins (such as folate, vitamin D, and carotenoids), low physical activity, and body fatness, all of which may act from childhood and adolescent years through adulthood...
July 2017: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
https://www.readbyqxmd.com/read/28776115/social-justice-epidemiology-and-health-inequalities
#18
Michael Marmot
A lifetime spent studying how social determinants of health lead to health inequalities has clarified many issues. First is that social stratification is an appropriate topic of study for epidemiologists. To ignore it would be to ignore a major source of variation in health in society. Not only is the social gradient in health appropriate to study but we have made progress both in understanding its causes and what can be done to address them. Post-modern 'critical theory' raises questions about the social construction of science...
August 3, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28774406/natural-history-of-acute-and-chronic-hepatitis-b-the-role-of-hbv-genotypes-and-mutants
#19
REVIEW
Chih-Lin Lin, Jia-Horng Kao
Molecular epidemiologic studies reveal remarkable differences in the geographical distribution of hepatitis B virus (HBV) genotypes. The frequency of mutants among HBV genotypes also varies. The role of HBV genotypes/mutants in the pathogenesis of HBV infection and natural history of HBV infection has been extensively investigated. The distribution of HBV genotypes in acute hepatitis B patients reflects the predominant genotypes in a given geographic area. In chronic hepatitis B patients, genotype C and D have a higher frequency of basal core promoter A1762T/G1764A mutations than genotype A and B...
June 2017: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/28759460/management-of-benign-ovarian-lesions-in-girls-a-trend-toward-fewer-oophorectomies
#20
Dani O Gonzalez, Peter C Minneci, Katherine J Deans
PURPOSE OF REVIEW: The management of benign ovarian lesions in girls is currently a controversial topic in the pediatric surgical literature. The purpose of this review is to highlight the epidemiology of benign ovarian masses, outline preoperative risk stratification strategies, review the indications and importance of ovary-sparing surgery (OSS), and discuss the impact of management algorithms. RECENT FINDINGS: Efforts across the United States and Canada to promote OSS have improved awareness about the role and safety of OSS for the management of benign ovarian masses in pediatric and adolescent girls...
October 2017: Current Opinion in Obstetrics & Gynecology
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