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Stratification epidemiology

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https://www.readbyqxmd.com/read/29777564/the-importance-of-non-regional-lymph-nodes-in-assigning-risk-in-primary-metastatic-prostate-cancer
#1
Adnan Ali, Alexander Hoyle, Hitesh Mistry, Noel W Clarke
OBJECTIVE: To determine the prognostic relevance of non-regional lymph nodes (NRLN) metastases presenting synchronously with bone metastases in metastatic prostate cancer (mPCa) for guiding treatment decisions based on oligometastatic definitions. PATIENTS AND METHODS: Patients diagnosed with mPCa between 2004 and 2013 were identified from the surveillance, epidemiology and end-results (SEER) database and were grouped by metastatic sites into only NRLN, only bone, bone + NRLN and other sites ± bone/NRLN metastases...
May 19, 2018: BJU International
https://www.readbyqxmd.com/read/29768284/predictive-value-of-excision-repair-cross-complementing-group-2-gene-lys751gln-and-asp312asn-polymorphisms-in-melanoma-risk
#2
Xue Zhou, Yong Zeng, Huayong Jiang, Limei Xia, Chuan Liu
Epidemiological studies have assessed the association between excision repair cross-complementing group 2 (ERCC2) Lys751Gln and Asp312Asn polymorphisms and melanoma risk with conflicting results. Relevant articles were searched from PubMed, Embase, and Web of Science with a time limit of 3 September 2016. Pooled odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of the association. We performed this meta-analysis with 12 studies including 6157 cases and 8873 controls for Lys751Gln and nine studies including 5037 cases and 7542 controls for Asp312Asn polymorphism...
May 15, 2018: Melanoma Research
https://www.readbyqxmd.com/read/29762858/evaluation-of-cardiovascular-risk-profile-a-comparative-analysis-between-cuore-algorithm-and-the-framingham-risk-scores
#3
G La Torre, V Palmeri, L Pagano, G Nati, S Sernia, A Mannocci
OBJECTIVE: Coronary heart diseases (CHD) are the leading cause of premature death and loss of disability adjusted life years in Europe. In order to implement appropriate health interventions as preventive tools, it is necessary to understand the epidemiological stratification of cardiovascular risk and the specific situation of each individual reality. This study investigates the reliability of two algorithms used to assess cardiovascular risk: the Framingham algorithm and the CUORE algorithm...
April 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29760460/seasonal-blood-pressure-variation-implications-for-cardiovascular-risk-stratification
#4
REVIEW
Pietro Amedeo Modesti, Stefano Rapi, Angela Rogolino, Benedetta Tosi, Giorgio Galanti
Long-term blood pressure variations contribute to an increased risk of cardiovascular events during cold season, requiring personalized management of antihypertensive medications in a single patient, and can influence the results of clinical trials and epidemiological surveys in population studies. In addition to blood pressure values, which guide the stratification of cardiovascular risk, other cardiovascular risk factor levels also tend to be higher in the winter months and lower in the summer months. The resultant estimation of individual cardiovascular risk may thus vary depending on the season...
May 14, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29755774/racial-ethnic-disparities-in-gallbladder-cancer-receipt-of-treatments
#5
Veeravich Jaruvongvanich, Buravej Assavapongpaiboon, Linda Wong
Background: Gallbladder cancer is a rare malignancy, yet it has a dismal prognosis. Overall survival has improved in all races/ethnicities except Hispanics and blacks. Despite improvements in gallbladder cancer management, it is not clear whether racial/ethnic disparities in stage at diagnosis and treatments exist that could potentially be the source of survival disparities. The purpose of this study was to examine race/ethnicity-specific trends in the stage of disease and receipt of treatments among adult gallbladder cancer patients in the US...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29755764/tumor-location-impact-in-stage-ii-and-iii-colon-cancer-epidemiological-and-outcome-evaluation
#6
Nesrine Mejri, Manel Dridi, Houda El Benna, Soumaya Labidi, Nouha Daoud, Hamouda Boussen
Background: We aimed to describe clinico-pathological characteristics and differences between right-sided (RCC) and left-sided colon cancer (LCC) in Tunisian population. We also analyzed outcome to determine whether location is of prognostic significance. Methods: Clinico-pathological characteristics and Kaplan Meier survival were compared between two groups of LCC [150] and RCC [53] patients with stage II and III adenocarcinoma treated with curative intent between 2003-2014...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29745768/dissecting-the-heterogeneity-of-localized-prostate-cancer-risk-groups-through-integration-of-percent-of-positive-cores
#7
Omar Abdel-Rahman
AIM: To develop a modified risk stratification scheme for localized prostate cancer incorporating percent of positive cores (PPC). METHODS: Surveillance, Epidemiology and End Results database was accessed for eligible patients. Assessment of the prognostic value of PPC was conducted in a multivariate Cox regression model. A modified risk stratification scheme was proposed. RESULTS: In a multivariate model, higher PPC was associated with worse cancer-specific survival (p < 0...
May 10, 2018: Future Oncology
https://www.readbyqxmd.com/read/29726959/melanocortin-4-receptor-pathway-dysfunction-in-obesity-patient-stratification-aimed-at-mc4r-agonist-treatment
#8
Kristin L Ayers, Benjamin S Glicksberg, Alastair S Garfield, Simonne Longerich, Joseph A White, Pengwei Yang, Lei Du, Thomas W Chittenden, Jeffery R Gulcher, Sophie Roy, Fred Fiedorek, Keith Gottesdiener, Sarah Cohen, Kari E North, Eric E Schadt, Shuyu D Li, Rong Chen, Lex H T Van der Ploeg
Context: The hypothalamic melanocortin 4 receptor (MC4R)-pathway serves a critical role in regulating bodyweight. Loss of function (LoF) mutations in the MC4R pathway including mutations in the POMC (1), PCSK1, LEPR (2) or the MC4R genes (3) have been shown to be causative of early-onset severe obesity. Methods: Through a comprehensive epidemiological analysis of known and predicted LoF variants in the POMC, PCSK1 and LEPR genes, we sought to estimate the number of US individuals with bi-allelic MC4R pathway LoF variants...
May 2, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29721333/diabetes-mellitus-and-bone-health-epidemiology-etiology-and-implications-for-fracture-risk-stratification
#9
Rodrigo J Valderrábano, Maria I Linares
Skeletal fractures can result when there are co-morbid conditions that negatively impact bone strength. Fractures represent an important source of morbidity and mortality, especially in older populations. Diabetes mellitus is a metabolic disorder that has reached worldwide epidemic proportions and is increasingly being recognized as a risk factor for fracture. Type 1 and Type 2 diabetes have different effects on bone mineral density but share common pathways, which lead to bone fragility. In this review, we discuss the available data on diabetes and fractures, bone density and the clinical implications for fracture risk stratification in current practice...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29715611/associations-between-short-term-exposure-to-ambient-sulfur-dioxide-and-increased-cause-specific-mortality-in-272-chinese-cities
#10
Lijun Wang, Cong Liu, Xia Meng, Yue Niu, Zhijing Lin, Yunning Liu, Jiangmei Liu, Jinlei Qi, Jinling You, Lap Ah Tse, Jianmin Chen, Maigeng Zhou, Renjie Chen, Peng Yin, Haidong Kan
BACKGROUND: Ambient sulfur dioxide (SO2 ) remains a major air pollutant in developing countries, but epidemiological evidence about its health effects was not abundant and inconsistent. OBJECTIVES: To evaluate the associations between short-term exposure to SO2 and cause-specific mortality in China. METHODS: We conducted a nationwide time-series analysis in 272 major Chinese cities (2013-2015). We used the over-dispersed generalized linear model together with the Bayesian hierarchical model to analyze the data...
April 28, 2018: Environment International
https://www.readbyqxmd.com/read/29707318/the-comparison-of-predictive-factors-regarding-prognoses-and-invasion-of-thymic-neuroendocrine-tumors-preoperatively-and-postoperatively
#11
Dongliang Bian, Mengfan Qi, Junjie Hu, Ye Ning, Feng Zhou, Ke Fei, Peng Zhang
Background: Thymic neuroendocrine tumors (TNT), in the anterior mediastinum, are extremely rare diseases which have significantly poor prognoses. Studies have rarely provided conclusive evidence of the prognostic factors of TNT. Standard therapies have been controversial. Methods: TNT patients (n=173) were enrolled from Surveillance, Epidemiology and End Results database (SEER). Univariate and multivariate analyses were utilized to evaluate predictive factors of prognoses...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29705685/translational-genomics-in-pancreatic-ductal-adenocarcinoma-a-review-with-re-analysis-of-tcga-dataset
#12
REVIEW
Jeffery Ho, Xianchun Li, Lin Zhang, Yonghao Liang, Wei Hu, Johnny C W Yau, Hung Chan, Tony Gin, Matthew T V Chan, Gary Tse, William K K Wu
Malignancy of the pancreas is a leading cause of cancer-related mortality, with the highest case-fatality of all cancers. Nevertheless, the lack of sensitive biomarkers and presence of biological heterogeneity precludes its early detection and effective treatment. The recent introduction of next-generation sequencing allows characterization of multiple driver mutations at genome- and exome-wide levels. Sequencing of DNA and RNA from circulating tumour cells has also opened an exciting era of non-invasive procedures for tumour detection and prognostication...
April 25, 2018: Seminars in Cancer Biology
https://www.readbyqxmd.com/read/29697304/deep-learning-in-pharmacogenomics-from-gene-regulation-to-patient-stratification
#13
Alexandr A Kalinin, Gerald A Higgins, Narathip Reamaroon, Sayedmohammadreza Soroushmehr, Ari Allyn-Feuer, Ivo D Dinov, Kayvan Najarian, Brian D Athey
This Perspective provides examples of current and future applications of deep learning in pharmacogenomics, including: identification of novel regulatory variants located in noncoding domains of the genome and their function as applied to pharmacoepigenomics; patient stratification from medical records; and the mechanistic prediction of drug response, targets and their interactions. Deep learning encapsulates a family of machine learning algorithms that has transformed many important subfields of artificial intelligence over the last decade, and has demonstrated breakthrough performance improvements on a wide range of tasks in biomedicine...
May 2018: Pharmacogenomics
https://www.readbyqxmd.com/read/29695379/common-mitochondrial-haplogroups-and-cutaneous-squamous-cell-carcinoma-risk
#14
Eric Jorgenson, Helene Choquet, Jie Yin, Maryam Asgari
BACKGROUND: Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer in America, and its incidence is substantially higher in men than women, but the reasons for the difference are unknown. We explored whether common mitochondrial DNA (mtDNA) haplogroups, which have been associated with cancer risk, and in particular squamous cell carcinoma risk arising in other organs, could explain this biological sex difference in cSCC susceptibility. METHODS: We performed a retrospective cohort study using data from the Genetic Epidemiology Research in Adult Health and Aging cohort comprised of 67,868 non-Hispanic white subjects (7,701 cSCC cases and 60,167 controls)...
April 25, 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29694999/novel-approaches-to-the-study-of-neonatal-infections
#15
Alessandro Borghesi, Mauro Stronati, Riccardo Castagnoli, Irene Ioimo, Cristian Achille, Paolo Manzoni, Chryssoula Tzialla
The pathogenesis of neonatal infection is incompletely understood. Neonatal immune immaturity and the microbial factors of virulence only partially explain the interindividual differences in the protective responses to the most common neonatal pathogens. Stratification of infants into high- and low-risk groups through epidemiological studies has been invaluable in designing preventive strategies and reducing the burden of neonatal infection. The discovery of the role of maternal antibodies (Abs) as, for instance, anti-capsular polysaccharide group B streptococcal (GBS) Abs, in protecting newborn infants against neonatal GBS sepsis, has been a milestone in the unraveling of the molecular underpinnings of susceptibility to infection in the neonatal age...
May 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29678941/autoantibodies-and-scleroderma-phenotype-define-subgroups-at-high-risk-and-low-risk-for-cancer
#16
Takeru Igusa, Laura K Hummers, Kala Visvanathan, Carrie Richardson, Fredrick M Wigley, Livia Casciola-Rosen, Antony Rosen, Ami A Shah
OBJECTIVES: Recent studies demonstrate autoantibodies are powerful tools to interrogate molecular events linking cancer and the development of autoimmunity in scleroderma. Investigating cancer risk in these biologically relevant subsets may provide an opportunity to develop personalised cancer screening guidelines. In this study, we examined cancer risk in distinct serologic and phenotypic scleroderma subsets and compared estimates with the general population. METHODS: Patients in the Johns Hopkins Scleroderma Center observational cohort were studied...
April 20, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29673392/geographical-information-system-gis-modeling-territory-receptivity-to-strengthen-entomological-surveillance-anopheles-nyssorhynchus-case-study-in-rio-de-janeiro-state-brazil
#17
Hermano Gomes Albuquerque, Paulo Cesar Peiter, Luciano M Toledo, Jeronimo A F Alencar, Paulo C Sabroza, Cristina G Dias, Jefferson P C Santos, Martha C Suárez-Mutis
BACKGROUND: Extra-Amazonian malaria mortality is 60 times higher than the Amazon malaria mortality. Imported cases correspond to approximately 90% of extra-Amazonian cases. Imported malaria could be a major problem if it occurs in areas with receptivity, because it can favor the occurrence of outbreaks or reintroductions of malaria in those areas. This study aimed to model territorial receptivity for malaria to serve as an entomological surveillance tool in the State of Rio de Janeiro, Brazil...
April 19, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29670401/the-impact-of-the-lymph-node-density-on-overall-survival-in-patients-with-wilms-tumor-a-seer-analysis
#18
Haisheng You, Jin Yang, Qingqing Liu, Lina Tang, Qingting Bu, Zhenyu Pan, Jun Lyu
Objective: The objective of this study was to determine the impact of the lymph node density (LND) on overall survival of patients with Wilms' tumor (WT) using the Surveillance, Epidemiology, and End Results (SEER) database. Methods: Data from the SEER database were extracted from patients with WT in whom the LND could be obtained. Patients were divided into a low LND group and high LND group. Survival curves based on the LND stratification were plotted using the Kaplan-Meier method and compared with the log-rank test...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29666958/ictal-interictal-continuum-patterns
#19
REVIEW
Gamaleldin M Osman, Davi F Araújo, Carolina B Maciel
PURPOSE OF REVIEW: To present data available on the epidemiology and significance of rhythmic and periodic patterns that lie on the ictal interictal continuum and propose an algorithm for the clinical approach to patients exhibiting these patterns. RECENT FINDINGS: There is accumulating evidence on the prognostic implications of various rhythmic and periodic patterns in the critically ill population. These patterns are not only associated with increased seizure risk but have also been associated with worse outcome and increased long-term risk of epilepsy in recent studies...
April 18, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29666118/a-simplified-scoring-system-in-de-novo-follicular-lymphoma-treated-initially-with-immunochemotherapy
#20
Emmanuel Bachy, Matthew J Maurer, Thomas M Habermann, Bénédicte Gelas-Dore, Delphine Maucort-Boulch, Jane A Estell, Eric Van den Neste, Réda Bouabdallah, Emmanuel Gyan, Andrew L Feldman, Joan Bargay, Alain Delmer, Susan L Slager, Maria Gomes da Silva, Olivier Fitoussi, David Belada, Hervé Maisonneuve, Tanin Intragumtornchai, Stephen M Ansell, Thierry Lamy, Peggy Dartigues, Brian K Link, John F Seymour, James R Cerhan, Gilles Salles
In follicular lymphoma (FL), no prognostic index has been built based solely on a cohort of patients treated with initial immunochemotherapy. There is currently a need to define parsimonious clinical models for trial stratification and to add on biomolecular factors. Here, we confirmed the validity of both the FLIPI and the FLIPI2 in the large prospective PRIMA trial cohort of 1,135 patients treated with initial R-chemotherapy +/- R maintenance. Furthermore, we developed a new prognostic tool comprising only 2 simple parameters (bone marrow involvement and β2-microglobulin (β2m)) to predict progression-free survival (PFS)...
April 17, 2018: Blood
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