keyword
https://read.qxmd.com/read/38424401/epidemiological-survey-on-post-mortem-coccidiosis-in-broiler-chicken-in-bejaia-province-northern-algeria
#21
JOURNAL ARTICLE
Amira Chahrazad Benabdelhak, Hanane Derbak, Hanane Titouah, Sofiane Aissanou, Nedjima Debbou-Iouknane, Abdelhanine Ayad
AIM: The epidemiological survey was carried out to determine the prevalence of eimeriosis in broiler chickens slaughtered depending the season, to determine the different Eimeria species causing the coccidiosis in poultry farms; and to assess the impact of Eimeria parasite on histomorphological structure and oxidative stress parameters of the intestine. MATERIALS AND METHODS: The study was conducted from December 2018 to December 2019 in the province of Bejaia, Algeria...
February 29, 2024: Acta Parasitologica
https://read.qxmd.com/read/38424375/gut-microbiota-dependent-phenylacetylglutamine-in-cardiovascular-disease-current-knowledge-and-new-insights
#22
REVIEW
Yaonan Song, Haoran Wei, Zhitong Zhou, Huiqing Wang, Weijian Hang, Junfang Wu, Dao Wen Wang
Phenylacetylglutamine (PAGln) is an amino acid derivate that comes from the amino acid phenylalanine. There are increasing studies showing that the level of PAGln is associated with the risk of different cardiovascular diseases. In this review, we discussed the metabolic pathway of PAGln production and the quantitative measurement methods of PAGln. We summarized the epidemiological evidence to show the role of PAGln in diagnostic and prognostic value in several cardiovascular diseases, such as heart failure, coronary heart disease/atherosclerosis, and cardiac arrhythmia...
March 1, 2024: Frontiers of Medicine
https://read.qxmd.com/read/38420854/chemical-and-cellular-formation-of-reactive-oxygen-species-from-secondary-organic-aerosols-in-epithelial-lining-fluid
#23
JOURNAL ARTICLE
M Shiraiwa, T Fang, J Wei, Psj Lakey, Bch Hwang, K C Edwards, S Kapur, Jem Mena, Y-K Huang, M A Digman, S A Weichenthal, S Nizkorodov, M T Kleinman
INTRODUCTION: Oxidative stress mediated by reactive oxygen species (ROS) is a key process for adverse aerosol health effects. Secondary organic aerosols (SOA) account for a major fraction of particulate matter with aerodynamic diameter ≤2.5 µm (PM2.5 ). PM2.5 inhalation and deposition into the respiratory tract causes the formation of ROS by chemical reactions and phagocytosis of macrophages in the epithelial lining fluid (ELF), but their relative contributions are not well quantified and their link to oxidative stress remains uncertain...
December 2023: Research Report (Res Rep Health Eff Inst)
https://read.qxmd.com/read/38420043/temperature-stability-of-urinary-f-2-isoprostane-and-8-hydroxy-2-deoxyguanosine
#24
JOURNAL ARTICLE
Katarzyna Kordas, Diala Ghazal, Elena I Queirolo, James R Olson, María Inés Beledo, Richard W Browne
BACKGROUND: Clinical and epidemiological studies employ long-term temperature storage but the effect of temperature on the stability of oxidative stress (OS) markers is unknown. We investigated the effects of storage at -20 °C and -80 °C over 4-9 months on F2 -isoprostanes (F2 -IsoP) and 8-hydroxy-2 ' -deoxyguanosine (8-OHdG) levels in urine of children, a population group among whom the measurement of these markers is still limited. METHODS: Paired spot urine samples from 87 children aged 8...
March 2024: Practical Laboratory Medicine
https://read.qxmd.com/read/38415695/a-comprehensive-review-of-the-intersection-between-asthma-and-depression
#25
REVIEW
Tahoora Abdul Nasir Surve, DhruviKumari D Sharma, Kiyan Ghani Khan, Neisha Ghanie, Riley Charanrak, Mouhammad Sharifa, Samreen Begum, Maria Jose Auz, Nozima Akbarova, Maneeth Mylavarapu
Objective To emphasize the necessity for increased research in this field, incorporating depression into the preventative, diagnostic, and therapeutic considerations for asthma. Additionally, we seek to highlight upcoming advancements that can be applied to simultaneously address these comorbidities, ultimately improving the overall well-being and quality of life for individuals coping with these conditions. Methods A rigorous search in PubMed using the MeSH terms "asthma" and "depression" was performed, and papers were screened by the authors in view of their eligibility to contribute to the study...
February 28, 2024: Journal of Asthma
https://read.qxmd.com/read/38408934/composite-dietary-antioxidant-index-and-sleep-health-a-new-insight-from-cross-sectional-study
#26
JOURNAL ARTICLE
Bingquan Xiong, Jiaxin Wang, Rui He, Guangsu Qu
BACKGROUND: Low-quality sleep and obstructive sleep apnea (OSA) can result in series of chronic diseases. Healthy diet has been considered as an effective and simple strategy to optimize sleep quality. However, current evidence on the correlation of dietary composite antioxidant intake with sleep health remained obscure. AIM OF THE STUDY: To determine the relationship of composite dietary antioxidant index (CDAI) and sleep health. METHODS: Cross-sectional analyses were based on National Health and Nutrition Examination Survey (NHANES) 2005-2008...
February 26, 2024: BMC Public Health
https://read.qxmd.com/read/38408815/suspended-particulate-matter-promotes-epithelial-to-mesenchymal-transition-in-alveolar-epithelial-cells-via-tgf-%C3%AE-1-mediated-ros-il-8-smad3-axis
#27
JOURNAL ARTICLE
Shahrzad Molavinia, Dian Dayer, Mohammad Javad Khodayar, Gholamreza Goudarzi, Maryam Salehcheh
Epidemiological evidence presents that dust storms are related to respiratory diseases, such as pulmonary fibrosis (PF). However, the precise underlying mechanisms of SPM-elicited adverse effects still need to be investigated. Epithelial-mesenchymal transition (EMT) process is a characteristic of PF. We discussed whether suspended particulate matter (SPM) is involved in EMT induction via transforming growth factor-β1 (TGF-β1). In this study, a detailed elemental analysis (55 elements), particle size, and morphology were determined...
July 2024: Journal of Environmental Sciences (China)
https://read.qxmd.com/read/38396763/sars-cov-2-infection-alters-the-phenotype-and-gene-expression-of-adipocytes
#28
JOURNAL ARTICLE
Paola Quaranta, Gaia Scabia, Barbara Storti, Alessia Dattilo, Lara Quintino, Paola Perrera, Cristina Di Primio, Mario Costa, Mauro Pistello, Ranieri Bizzarri, Margherita Maffei
Epidemiological evidence emphasizes that excess fat mass is associated with an increased risk of severe COVID-19 disease. Nevertheless, the intricate interplay between SARS-CoV-2 and adipocytes remains poorly understood. It is crucial to decipher the progression of COVID-19 both in the acute phase and on long-term outcomes. In this study, an in vitro model using the human SGBS cell line (Simpson-Golabi-Behmel syndrome) was developed to investigate the infectivity of SARS-CoV-2 in adipocytes, and the effects of virus exposure on adipocyte function...
February 8, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38395115/peripartum-cardiomyopathy-unveiled-etiology-diagnosis-and-therapeutic-insights
#29
REVIEW
Ardea Safira, Angela Kimberly Tjahjadi, Galih Januar Adytia, Alief Waitupu, Henry Sutanto
Peripartum cardiomyopathy (PPCM) remains a significant challenge in maternal health, marked by its unpredictable onset and varied clinical outcomes. With rising incidence rates globally, understanding PPCM is vital for improving maternal care and prognosis. This review aims to consolidate current knowledge on PPCM, highlighting recent advancements in its diagnosis, management, and therapeutic approaches. This comprehensive review delves into the epidemiology of PPCM, underscoring its global impact and demographic variations...
February 21, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38392221/plastoquinone-derivative-skq1-improved-the-biliary-intraepithelial-neoplasia-during-liver-fluke-infection
#30
JOURNAL ARTICLE
Oxana Zaparina, Anna Kovner, Viktoria Petrova, Nataliya Kolosova, Viatcheslav Mordvinov, Maria Pakharukova
Carcinogenic food-borne liver fluke infections are a serious epidemiological threat worldwide. The major complications of Opisthorchis felineus infection are chronic inflammation and biliary intraepithelial neoplasia. Although evidence has accumulated that increased reactive oxygen species production is observed in liver fluke infection, a direct relationship between the oxidative stress and biliary intraepithelial neoplasia has not been shown. Quinones and SkQ1, a derivative of plastoquinone, have been demonstrated to be cytoprotective in numerous liver injuries due to their potent antioxidant properties...
February 17, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38382009/association-of-pm-2-5-exposure-and-alzheimer-disease-pathology-in-brain-bank-donors-effect-modification-by-apoe-genotype
#31
JOURNAL ARTICLE
Grace M Christensen, Zhenjiang Li, Donghai Liang, Stefanie Ebelt, Marla Gearing, Allan I Levey, James J Lah, Aliza Wingo, Thomas Wingo, Anke Hüls
BACKGROUND AND OBJECTIVES: Fine particulate matter (PM2.5 ) exposure has been found to be associated with Alzheimer disease (AD) and is hypothesized to cause inflammation and oxidative stress in the brain, contributing to neuropathology. The APOE gene, a major genetic risk factor of AD, has been hypothesized to modify the association between PM2.5 and AD. However, little prior research exists to support these hypotheses. This study investigates the association between traffic-related PM2...
March 12, 2024: Neurology
https://read.qxmd.com/read/38380104/phenotypic-and-transcriptional-characterization-of-f-tularensis-lvs-during-transition-into-a-viable-but-non-culturable-state
#32
JOURNAL ARTICLE
Stuart Cantlay, Nicole L Garrison, Rachelle Patterson, Kassey Wagner, Zoei Kirk, Jun Fan, Donald A Primerano, Mara L G Sullivan, Jonathan M Franks, Donna B Stolz, Joseph Horzempa
Francisella tularensis is a gram-negative, intracellular pathogen which can cause serious, potentially fatal, illness in humans. Species of F. tularensis are found across the Northern Hemisphere and can infect a broad range of host species, including humans. Factors affecting the persistence of F. tularensis in the environment and its epidemiology are not well understood, however, the ability of F. tularensis to enter a viable but non-culturable state (VBNC) may be important. A broad range of bacteria, including many pathogens, have been observed to enter the VBNC state in response to stressful environmental conditions, such as nutrient limitation, osmotic or oxidative stress or low temperature...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38376568/electronic-cigarettes-and-cardiovascular-disease-epidemiological-and-biological-links
#33
REVIEW
Huiqi Zong, Zhekai Hu, Weina Li, Mina Wang, Qi Zhou, Xiang Li, Hongxu Liu
Electronic cigarettes (e-cigarettes), as alternative nicotine delivery methods, has rapidly increased among youth and adults in recent years. However, cardiovascular safety is an important consideration regarding e-cigarettes usage. e-cigarette emissions, including nicotine, propylene glycol, flavorings, nitrosamine, and metals, might have adverse effects on cardiovascular health. A large body of epidemiological evidence has indicated that e-cigarettes are considered an independent risk factor for increased rates of cardiovascular disease occurrence and death...
February 20, 2024: Pflügers Archiv: European Journal of Physiology
https://read.qxmd.com/read/38373549/reproductive-toxicity-of-pfoa-pfos-and-their-substitutes-a-review-based-on-epidemiological-and-toxicological-evidence
#34
REVIEW
Wenshan Shi, Zengli Zhang, Mei Li, Huiyu Dong, Jiafu Li
Per- and polyfluoroalkyl substances (PFAS) have already drawn a lot of attention for their accumulation and reproductive toxicity in organisms. Perfluorooctanoic acid (PFOA) and perfluorooctanoic sulfonate (PFOS), two representative PFAS, are toxic to humans and animals. Due to their widespread use in environmental media with multiple toxicities, PFOA and PFOS have been banned in numerous countries, and many substitutes have been produced to meet market requirements. Unfortunately, most alternatives to PFOA and PFOS have proven to be cumulative and highly toxic...
February 17, 2024: Environmental Research
https://read.qxmd.com/read/38360668/particulate-matter-from-car-exhaust-alters-function-of-human-ipsc-derived-microglia
#35
JOURNAL ARTICLE
Henna Jäntti, Steffi Jonk, Mireia Gómez Budia, Sohvi Ohtonen, Ilkka Fagerlund, Mohammad Feroze Fazaludeen, Päivi Aakko-Saksa, Alice Pebay, Šárka Lehtonen, Jari Koistinaho, Katja M Kanninen, Pasi I Jalava, Tarja Malm, Paula Korhonen
BACKGROUND: Air pollution is recognized as an emerging environmental risk factor for neurological diseases. Large-scale epidemiological studies associate traffic-related particulate matter (PM) with impaired cognitive functions and increased incidence of neurodegenerative diseases such as Alzheimer's disease. Inhaled components of PM may directly invade the brain via the olfactory route, or act through peripheral system responses resulting in inflammation and oxidative stress in the brain...
February 15, 2024: Particle and Fibre Toxicology
https://read.qxmd.com/read/38351350/association-between-lead-and-circulating-markers-of-inflammation-among-traffic-enforcers-in-metro-manila-philippines-the-mmda-traffic-enforcer-s-health-study
#36
JOURNAL ARTICLE
Zypher Jude G Regencia, Wenyuan Zhao, Carolina Torres-Roja, Byron C Jones, Emmanuel S Baja
PURPOSE: Several epidemiological studies have linked lead (Pb) exposure to induced oxidative stress and the promotion of inflammatory response. We performed a within-subjects study (repeated measures study) to evaluate the relationship between the concentration of blood lead (B-Pb) and toenail lead (T-Pb) and circulating markers of inflammation. METHODS: We evaluated the associations between B-Pb concentrations and T-Pb concentrations and circulating markers of inflammation, soluble intracellular adhesion molecule-1 (s-ICAM-1), soluble vascular adhesion molecule-1 (s-VCAM-1), and high-sensitivity C-reactive protein (hs-CRP) on 158 traffic enforcers from the Metropolitan Manila Development Authority (MMDA) traffic enforcer's health study...
February 13, 2024: International Archives of Occupational and Environmental Health
https://read.qxmd.com/read/38350531/quantitative-modeling-of-in-vitro-data-using-an-adverse-outcome-pathway-for-the-risk-assessment-of-decreased-lung-function-in-humans
#37
JOURNAL ARTICLE
Alain Sewer, Marja Talikka, Florian Calvino-Martin, Karsta Luettich, Anita Iskandar
In the absence of epidemiological data, there is a need to develop computational models that convert in vitro findings to human disease risk predictions following toxicant exposure. In such efforts, in vitro data can be evaluated in the context of adverse outcome pathways (AOPs) that organize mechanistic knowledge based on empirical evidence into a sequence of molecular-, cellular-, tissue-, and organ-level key events that precede an adverse outcome (AO). Here we combined data from advanced in vitro organotypic airway models exposed to combustible cigarette (CC) smoke or Tobacco Heating System (THS) aerosol with an AOP for increased oxidative stress leads to decreased lung function...
February 11, 2024: Toxicology Letters
https://read.qxmd.com/read/38349491/cadmium-as-a-male-reproductive-toxicant-and-natural-and-non-natural-ways-to-tackle-it-a-review
#38
REVIEW
Uddesh Ramesh Wanjari, Abilash Valsala Gopalakrishnan
Cadmium (Cd) is a naturally occurring environmental pollutant, a toxic substance that causes oxidative stress. According to epidemiological studies, the data suggested that environmental and occupational Cd exposure may be related to several diseases and severe testicular damage. However, studies are going on to explore the mechanism of Cd-induced male reproductive toxicity and its treatment strategies. Currently, researchers are focusing on naturally occurring bioactive compounds, plant extracts, and biochemical, which have better efficacy, less toxicity, and high bioavailability...
February 13, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38349408/zbtb16-increases-susceptibility-of-atrial-fibrillation-in-type-2-diabetic-mice-via-txnip-trx2-signaling
#39
JOURNAL ARTICLE
Zhi-Xing Wei, Xing-Xing Cai, Yu-Dong Fei, Qian Wang, Xiao-Liang Hu, Cheng Li, Jian-Wen Hou, Yu-Li Yang, Tai-Zhong Chen, Xiao-Lei Xu, Yue-Peng Wang, Yi-Gang Li
Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia, and recent epidemiological studies suggested type 2 diabetes mellitus (T2DM) is an independent risk factor for the development of AF. Zinc finger and BTB (broad-complex, tram-track and bric-a-brac) domain containing 16 (Zbtb16) serve as transcriptional factors to regulate many biological processes. However, the potential effects of Zbtb16 in AF under T2DM condition remain unclear. Here, we reported that db/db mice displayed higher AF vulnerability and Zbtb16 was identified as the most significantly enriched gene by RNA sequencing (RNA-seq) analysis in atrium...
February 13, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38348714/quantitative-proteomics-study-of-carnosine-effect-in-an-animal-model-of-western-diet-induced-nonalcoholic-fatty-liver-disease
#40
JOURNAL ARTICLE
Fernando Moreto, Jéssica Leite Garcia, Ana Lúcia Dos Anjos Ferreira, Silvia Radrezza, Mariane Róvero Costa, Guilherme Ribeiro Romualdo, Nubia Alves Grandini, Giancarlo Aldini, Camila Renata Correa, Alfonsina D'Amato
The nonalcoholic fatty liver disease (NAFLD), which is closely related to westernized dietary (WD) patterns, displays a rising epidemiological and economic burden. Since there is no pharmacological therapy approved for this disease, mechanistic studies are warranted. In this work, we investigated the action of carnosine (CAR), a natural dipeptide with several protection roles against oxidative stress in the liver of NAFLD rats. NAFLD was induced by WD-rich sugars and fat, verifying the histological evidence of steatosis...
February 2024: Journal of Biochemical and Molecular Toxicology
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