keyword
MENU ▼
Read by QxMD icon Read
search

Oxidative stress epidemiology

keyword
https://www.readbyqxmd.com/read/29770164/aquaporin-membrane-channels-in-oxidative-stress-cell-signaling-and-aging-recent-advances-and-research-trends
#1
REVIEW
Grazia Tamma, Giovanna Valenti, Elena Grossini, Sandra Donnini, Angela Marino, Raul A Marinelli, Giuseppe Calamita
Reactive oxygen species (ROS) are produced as a result of aerobic metabolism and as by-products through numerous physiological and biochemical processes. While ROS-dependent modifications are fundamental in transducing intracellular signals controlling pleiotropic functions, imbalanced ROS can cause oxidative damage, eventually leading to many chronic diseases. Moreover, increased ROS and reduced nitric oxide (NO) bioavailability are main key factors in dysfunctions underlying aging, frailty, hypertension, and atherosclerosis...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29758289/exposure-to-a-combination-of-formaldehyde-and-dinp-aggravated-asthma-like-pathology-through-oxidative-stress-and-nf-%C3%AE%C2%BAb-activation
#2
Jun Kang, Jiufei Duan, Jing Song, Chen Luo, Hong Liu, Baizhan Li, Xu Yang, Wei Yu, Mingqing Chen
Several epidemiological and experimental studies indicate a positive association between exposure to formaldehyde or phthalates and allergic asthma. However, nothing is yet known about the effects of exposure to formaldehyde and phthalates together, nor the role of each on allergic asthma. Here, we investigated the effects of a combined exposure to formaldehyde and diisononyl phthalate (DINP) on asthma-like pathology in mice, and determined the underlying mechanisms implicated in NF-κB and ROS. Mice were exposed to formaldehyde and/or DINP and sensitization with OVA...
May 11, 2018: Toxicology
https://www.readbyqxmd.com/read/29757566/-traffic-related-air-pollution-and-allergic-rhinitis
#3
REVIEW
Guo Liu, Shi Xi Liu
Exposure to traffic-related air pollutants(TRAP)has been implicated in airway allergic diseases.Recent findings include epidemiologic and mechanistic studies that shed new light on the impact of TRAP on allergic rhinitis(AR)and the biology underlying this impact.These studies have found that oxidative stress induced by TRAP could affect the axis of epithelial cell-dendritic cell-T cell towards a T-helper 2 immune response,which is the major mechanism between TRAP and AR.Further,epigenetics and microRNA might be involved in this process...
January 20, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29753823/analysis-of-differentially-changed-gene-expression-in-ea-hy926-human-endothelial-cell-after-exposure-of-fine-particulate-matter-on-the-basis-of-microarray-profile
#4
Yan Wang, Lilin Xiong, Tianshu Wu, Ting Zhang, Lu Kong, Yuying Xue, Meng Tang
Epidemiological studies have illustrated that PM2.5 is closely related to cardiovascular disease (CVD), but underlying toxicological mechanisms are not yet clear. The main purpose of this study is to disclose the potential biological mechanisms responsible for PM2.5-dependent adverse cardiovascular outcomes through the appliance of genome-wide transcription microarray. From results, compared with the control group, there are 97 genes significantly altered in 2.5 μg/cm2 PM2.5 treated group and 440 differentially expressed genes in 10 μg/cm2 group...
May 10, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29732485/role-of-melatonin-in-aluminum-related-neurodegenerative-disorders-a-review
#5
José L Esparza, Mercedes Gómez, José L Domingo
Aluminum (Al), a potentially neurotoxic element, provokes various adverse effects on human health such as dialysis dementia, osteomalacia, and microcytic anemia. It has been also associated with serious neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis, and Parkinsonism dementia of Guam. The "aluminum hypothesis" of AD assumes that the metal complexes can potentiate the rate of aggregation of amyloid-β (Aβ), enhancing the toxicity of this peptide, and being able of contributing to the pathogenesis of AD...
May 7, 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/29726912/relationship-of-the-oxidative-damage-biomarker-8-epi-prostaglandin-f2%C3%AE-to-risk-of-lung-cancer-development-in-the-shanghai-cohort-study
#6
Jian-Min Yuan, Steven G Carmella, Renwei Wang, Yu-Ting Tan, Jennifer Adams-Haduch, Yu-Tang Gao, Stephen S Hecht
It has been hypothesized that the pathogenesis of lung cancer induced by cigarette smoking involves oxidative damage by free radicals. Epidemiological data on biomarkers of oxidative damage and risk of lung cancer development are sparse. A nested case-control study of 610 lung cancer cases and 610 matched controls was conducted within a prospective cohort of 18,244 Chinese men in Shanghai, China. The concentrations of 8-epi-prostaglandin F2α (8-epiPGF2α), a biomarker of oxidative stress, were determined in baseline urine samples using a validated mass-spectrometry assay...
May 3, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29724134/cigarette-smoking-and-the-pathogenesis-of-systemic-lupus-erythematosus
#7
Cameron B Speyer, Karen H Costenbader
Systemic lupus erythematosus (SLE) is a multi-system inflammatory autoimmune disease of incompletely understood etiology. It is thought that environmental exposures "trigger" or accelerate the disease in genetically-predisposed individuals. Areas covered: Substantial epidemiological evidence exists to support the association between cigarette smoking and the risk of incident SLE. Recent evidence points to current smoking as the specific risk factor, with decreasing risk 5 years after smoking cessation, and the greatest risk for disease characterized by the presence of SLE- specific autoantibodies...
May 3, 2018: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/29720843/modulatory-effect-of-carotenoid-supplement-constituting-lutein-and-zeaxanthin-10-1-on-anti-oxidant-enzymes-and-macular-pigments-level-in-rats
#8
Jayashree Madhavan, Sundaram Chandrasekharan, M K Priya, Ashok Godavarthi
Background: Human eye is constantly exposed to different wavelengths and intensities of light. Oxidative stress results in distinct changes to retinal organs and tissues. Macular pigments (lutein and zeaxanthin), present in the central macular region, provide protection from photodamages by absorption of high energy blue light and also by virtue of their anti-oxidant activity. Ocular phototoxicity is thus prevented by our efficient anti-oxidant system, in both young and old. One of the best commercial sources of pure lutein and zeaxanthin is Marigold flowers...
April 2018: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29720230/urate-inhibits-microglia-activation-to-protect-neurons-in-an-lps-induced-model-of-parkinson-s-disease
#9
Li-Hui Bao, Ya-Nan Zhang, Jian-Nan Zhang, Li Gu, Hui-Min Yang, Yi-Ying Huang, Ning Xia, Hong Zhang
BACKGROUND: Multiple risk factors contribute to the progression of Parkinson's disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level and a lower risk of developing PD. However, the mechanistic basis for this association remains unclear. Urate protects dopaminergic neurons from cell death induced by oxidative stress. Here, we investigated a novel role of urate in microglia activation in a lipopolysaccharide (LPS)-induced PD model...
May 2, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29718795/dietary-flavanols-a-review-of-select-effects-on-vascular-function-blood-pressure-and-exercise-performance
#10
Yousef A Al-Dashti, Roberta R Holt, Charles L Stebbins, Carl L Keen, Robert M Hackman
An individual's diet affects numerous physiological functions and can play an important role in reducing the risk of cardiovascular disease. Epidemiological and clinical studies suggest that dietary flavanols can be an important modulator of vascular risk. Diets and plant extracts rich in flavanols have been reported to lower blood pressure, especially in prehypertensive and hypertensive individuals. Flavanols may act in part through signaling pathways that affect vascular function, nitric oxide availability, and the release of endothelial-derived relaxing and constricting factors...
May 2, 2018: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/29709849/sources-behaviour-and-environmental-and-human-health-risks-of-high-technology-rare-earth-elements-as-emerging-contaminants
#11
REVIEW
Willis Gwenzi, Lynda Mangori, Concilia Danha, Nhamo Chaukura, Nothando Dunjana, Edmond Sanganyado
Recent studies show that high-technology rare earth elements (REEs) of anthropogenic origin occur in the environment including in aquatic systems, suggesting REEs are contaminants of emerging concern. However, compared to organic contaminants, there is a lack of comprehensive reviews on the anthropogenic sources, environmental behaviour, and public and ecological health risks of REEs. The current review aims to: (1) identify anthropogenic sources, transfer mechanisms, and environmental behaviour of REEs; (2) highlight the human and ecological health risks of REEs and propose mitigation measures; and (3) identify knowledge gaps and future research directions...
April 26, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29702491/acute-kidney-injury-to-chronic-kidney-disease-transition-insufficient-cellular-stress-response
#12
Sarah A Strausser, Daisuke Nakano, Tomokazu Souma
PURPOSE OF REVIEW: Recent epidemiological and preclinical mechanistic studies provide strong evidence that acute kidney injury (AKI) and chronic kidney disease (CKD) form an interconnected syndrome. Injured kidneys undergo a coordinated reparative process with an engagement of multiple cell types after injury; however, maladaptation to the injury subjects kidneys to a vicious cycle of fibrogenesis and nephron loss. In this review, we will outline and discuss the pathogenesis of AKI-to-CKD transition with an emphasis on dysregulated 'cellular stress adaptation' as a potential therapeutic target...
April 26, 2018: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/29698898/carbon-nanotube-and-nanofiber-exposure-and-sputum-and-blood-biomarkers-of-early-effect-among-u-s-workers
#13
John D Beard, Aaron Erdely, Matthew M Dahm, Marie A de Perio, M Eileen Birch, Douglas E Evans, Joseph E Fernback, Tracy Eye, Vamsi Kodali, Robert R Mercer, Stephen J Bertke, Mary K Schubauer-Berigan
BACKGROUND: Carbon nanotubes and nanofibers (CNT/F) are increasingly used for diverse applications. Although animal studies suggest CNT/F exposure may cause deleterious health effects, human epidemiological studies have typically been small, confined to single workplaces, and limited in exposure assessment. OBJECTIVES: We conducted an industrywide cross-sectional epidemiological study of 108 workers from 12 U.S. sites to evaluate associations between occupational CNT/F exposure and sputum and blood biomarkers of early effect...
April 23, 2018: Environment International
https://www.readbyqxmd.com/read/29684876/investigating-the-association-between-urinary-levels-of-acrylonitrile-metabolite-n-acetyl-s-2-cyanoethyl-l-cysteine-and-the-oxidative-stress-product-8-hydroxydeoxyguanosine-in-adolescents-and-young-adults
#14
Chien-Yu Lin, Hui-Ling Lee, Fung-Chang Sung, Ta-Chen Su
Acrylonitrile is a colorless volatile liquid mostly present in tobacco smoke. Acrylonitrile exposure has shown to increase oxidative stress in animal studies; however, there was no previous research in human epidemiology. In this study, 853 subjects were recruited from a cohort of Taiwanese adolescents and young adults to investigate the association between urinary concentrations of the acrylonitrile metabolite N-acetyl-S-(2-cyanoethyl)-L-cysteine (CEMA), the oxidative stress product 8-hydroxydeoxyguanosine (8-OHdG) and cardiovascular disease (CVD) risk factors...
April 20, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29680174/human-serum-albumin-in-cardiovascular-diseases
#15
REVIEW
Stephane Arques
Cardiovascular diseases are the leading cause of death worldwide. Endothelial dysfunction, inflammation and oxidative stress are at the forefront in the onset and development of atherosclerosis and many cardiovascular diseases. Epidemiological evidence is that low serum albumin levels are linked to incident ischemic heart disease, heart failure, atrial fibrillation, stroke and venous thromboembolism, independent of risk factors, body mass index and inflammation. Hypoalbuminemia has also emerged as an independent prognosticator in many cardiovascular diseases, such as coronary artery disease, heart failure, congenital heart disease, infective endocarditis and stroke, even after adjusting for usual causal factors and prognostic markers...
April 18, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29679627/diabetes-and-cancer-pathophysiological-fundamentals-of-a-dangerous-affair
#16
REVIEW
Angelo Cignarelli, Valentina Annamaria Genchi, Irene Caruso, Annalisa Natalicchio, Sebastio Perrini, Luigi Laviola, Francesco Giorgino
Diabetes and cancer are worldwide chronic diseases with a major impact on the quality and expectancy of life. Metabolic abnormalities observed during the onset and progression of diabetes may have a critical role on the initiation and progression of carcinogenesis. To date, there are no conclusive data on the mechanisms underlying the relationship between diabetes and any type of human cancer. However, recent evidence suggests that both hyperglycemia and hyperinsulinemia in diabetes could elicit cell damage responses, such as glucotoxicity, lipotoxicity and oxidative stress, which participate in the cell transformation process raising the risk of cancer development...
April 19, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29678824/metabolic-karma-the-atherogenic-legacy-of-diabetes-the-2017-edwin-bierman-award-lecture
#17
Mark Emmanuel Cooper, Assam El-Osta, Terri Jean Allen, Anna Margareta Dorothea Watson, Merlin Christopher Thomas, Karin Agnes Maria Jandeleit-Dahm
Cardiovascular disease, despite all the recent advances in treatment of the various risk factors, remains the major cause of mortality in both type 1 and type 2 diabetes. Experimental models of diabetes-associated atherosclerosis, despite their limitations in recapitulating the human context, have assisted in the elucidation of molecular and cellular pathways implicated in the development and progression of macrovascular injury in diabetes. Our own studies have emphasized the role of oxidative stress and advanced glycation and identified potential targets for vasoprotective therapies in the setting of diabetes...
May 2018: Diabetes
https://www.readbyqxmd.com/read/29673971/changes-in-trophoblasts-gene-expression-in-response-to-perchlorate-exposition
#18
De la Peña Sol, Santiago-Roque Isela, Olivo-Vidal Zendy, Navarro-Meza Mónica, Xochihua-Rosas Irene, Arroyo-Helguera Omar
Contaminated water with chlorates is a public health problem associated with iodine deficiency. Epidemiological evidence shows that iodine deficiency is a risk factor for preeclampsia (PE). In this study we use human BeWo trophoblast cells exposed to perchlorate (KClO4 ) and changes in gene expression were analyzed by microarrays, quantitative RT-PCR (qRT-PCR) and immunoblot. The microarray analysis identified 48 transcripts up-regulated and 112 down-regulated in comparison with non-exposed trophoblast. The qRT-PCR analysis confirmed changes in GAS7, PKP2, Emilin, Dynatic 3, protocadherins 11, 15, gamma A12, EGFR, SAFB1, ACE2, ANXA2, Apoliprotein E, SREBF1, and C/EBP-β...
April 16, 2018: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/29618600/outdoor-air-pollution-exhaled-8-isoprostane-and-current-asthma-in-adults-the-egea-study
#19
Anaïs Havet, Farid Zerimech, Margaux Sanchez, Valérie Siroux, Nicole Le Moual, Bert Brunekreef, Morgane Stempfelet, Nino Künzli, Bénédicte Jacquemin, Régis Matran, Rachel Nadif
Associations between outdoor air pollution and asthma in adults are still scarce, and the underlying biological mechanisms are poorly understood. Our aim was to study the associations between 1) long-term exposure to outdoor air pollution and current asthma, 2) exhaled 8-isoprostane (8-iso; a biomarker related to oxidative stress) and current asthma, and 3) outdoor air pollution and exhaled 8-iso.Cross-sectional analyses were conducted in 608 adults (39% with current asthma) from the first follow-up of the French case-control and family study on asthma (EGEA; the Epidemiological study of the Genetic and Environmental factors of Asthma)...
April 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29616443/changes-in-the-serum-urate-level-can-predict-the-development-of-parkinsonism-in-the-6-hydroxydopamine-animal-model
#20
Mohammad Reza Sarukhani, Hashem Haghdoost-Yazdi, Gilda Khandan-Chelarci
Epidemiological studies indicate that a higher plasma level of uric acid (UA) associates with the reduced risk of Parkinson's disease (PD). To confirm the role of UA as a biomarker for PD, we evaluated changes in the serum UA level in the 6-hydroxydopamine (6-OHDA)-induced hemiparkinsonism in rat. For this purpose, 6-OHDA was administered in the medial forebrain bundle by stereotaxic surgery. According to the apomorphine-induced rotational test, the increased intensity of behavioral symptoms as a function of time was associated with the further reduction of UA level...
April 3, 2018: Neurochemical Research
keyword
keyword
84015
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"