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Oxidative stress epidemiology

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https://www.readbyqxmd.com/read/28801790/cardiovascular-disease-the-nitric-oxide-pathway-and-risk-of-cognitive-impairment-and-dementia
#1
REVIEW
Blossom C M Stephan, Stephanie L Harrison, Hannah A D Keage, Abrar Babateen, Louise Robinson, Mario Siervo
PURPOSE OF REVIEW: In this review, we summarise the evidence on the association between cardiovascular disease (CVD) and cognitive impairment and explore the role of the nitric oxide (NO) pathway as a causal mechanism. RECENT FINDINGS: Evidence from epidemiological studies suggests that the presence of CVD and its risk factors in midlife is associated with an increased risk of later life cognitive impairment and dementia. It is unclear what is driving this association but risk may be conveyed via an increase in neurodegeneration (e...
August 11, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28795381/research-progress-on-prevention-and-treatment-of-glucolipid-metabolic-disease-with-integrated-traditional-chinese-and-western-medicine
#2
Jiao Guo
Hyperlipidemia, type 2 diabetes mellitus, nonalcoholic fatty liver and many other metabolic disorder are frequently co-existing in patients. In addition, these diseases are closely related in pathophysiological settings. However, increasing of the disease incidence, lacking of comprehensive prevention and control measurements against the key pathology point concomitant occurrence with the pattern of the single disease, single target therapy, that is leading therapeutic strategy for these metabolic disorders in the setting of Western medicine (WM)...
June 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28792056/anthocyanins-in-black-rice-soybean-and-purple-corn-increase-fecal-butyric-acid-and-prevent-liver-inflammation-in-high-fat-diet-induced-obese-mice
#3
Tao Wu, Xueqi Guo, Min Zhang, Lu Yang, Rui Liu, Jinjin Yin
Epidemiological evidence indicates that anthocyanin consumption reduces the incidence of chronic and degenerative diseases. Therefore, the present study aimed to determine whether black rice anthocyanin (BRA), black soybean anthocyanin (BSA), and purple corn anthocyanin (PCA) could mitigate oxidative stress and inflammation associated obesity in C57BL/6 mice fed with a high-fat diet. BRA, BSA, or PCA was administered at doses of 200 mg kg(-1) throughout the 12-week experiment and reduced the bodyweight by 9...
August 9, 2017: Food & Function
https://www.readbyqxmd.com/read/28790228/association-between-serum-uric-acid-and-non-alcoholic-fatty-liver-disease-a-meta-analysis
#4
Guntur Darmawan, Laniyati Hamijoyo, Irsan Hasan
BACKGROUND: non-alcoholic fatty liver disease (NAFLD) is known to be associated with some metabolic disorders. Recent studies suggested the role of uric acid in NAFLD through oxidative stress and inflammatory process. This study is aimed to evaluate the association between serum uric acid and NAFLD. METHODS: a systematic literature review was conducted using Pubmed and Cochrane library. The quality of all studies was assessed using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)...
April 2017: Acta Medica Indonesiana
https://www.readbyqxmd.com/read/28777965/metals-and-neurodegenerative-diseases-a-systematic-review
#5
REVIEW
Calogero Edoardo Cicero, Giovanni Mostile, Rosario Vasta, Venerando Rapisarda, Salvatore Santo Signorelli, Margherita Ferrante, Mario Zappia, Alessandra Nicoletti
Neurodegenerative processes encompass a large variety of diseases with different pathological patterns and clinical presentation such as Amyotrophic Lateral Sclerosis (ALS), Alzheimer Disease (AD) and Parkinson's disease (PD). Genetic mutations have a known causative role, but the majority of cases are likely to be probably caused by a complex gene-environment interaction. Exposure to metals has been hypothesized to increase oxidative stress in brain cells leading to cell death and neurodegeneration. Neurotoxicity of metals has been demonstrated by several in vitro and in vivo experimental studies and it is likely that each metal could be toxic through specific pathways...
August 1, 2017: Environmental Research
https://www.readbyqxmd.com/read/28777356/health-effects-of-carotenoids-during-pregnancy-and-lactation
#6
REVIEW
Monika A Zielińska, Aleksandra Wesołowska, Beata Pawlus, Jadwiga Hamułka
Adequate nutrition is particularly important during pregnancy since it is needed not only for maintaining the health of the mother, but also determines the course of pregnancy and its outcome, fetus development as well as the child's health after birth and during the later period of life. Data coming from epidemiological and interventions studies support the observation that carotenoids intake provide positive health effects in adults and the elderly population. These health effects are the result of their antioxidant and anti-inflammatory properties...
August 4, 2017: Nutrients
https://www.readbyqxmd.com/read/28774687/the-environment-and-male-reproduction-the-effect-of-cadmium-exposure-on-reproductive-system-and-semen-quality-and-its-implication-in-fertility
#7
REVIEW
Cristina de Angelis, Mariano Galdiero, Claudia Pivonello, Ciro Salzano, Daniele Gianfrilli, Prisco Piscitelli, Andrea Lenzi, Annamaria Colao, Rosario Pivonello
Cadmium is an environmental pollutant known as endocrine disruptor. Testis is particularly susceptible to cadmium, and testis injury occurs at high but even low levels of exposure. Cadmium reproductive toxicity is mediated by multiple mechanisms, including structural damage to testis vasculature and blood-testis barrier, inflammation, cytotoxicity on Sertoli and Leydig cells, oxidative stress, apoptosis, epigenetic actions, and disturbance of the hypothalamus-pituitary-gonadal axis. The current review outlines epidemiological observational findings from environmental and occupational exposure in humans, and reports experimental studies in humans and animals...
July 31, 2017: Reproductive Toxicology
https://www.readbyqxmd.com/read/28770024/metformin-and-its-sulfenamide-prodrugs-inhibit-human-cholinesterase-activity
#8
Magdalena Markowicz-Piasecka, Joanna Sikora, Łukasz Mateusiak, Elżbieta Mikiciuk-Olasik, Kristiina M Huttunen
The results of epidemiological and pathophysiological studies suggest that type 2 diabetes mellitus (T2DM) may predispose to Alzheimer's disease (AD). The two conditions present similar glucose levels, insulin resistance, and biochemical etiologies such as inflammation and oxidative stress. The diabetic state also contributes to increased acetylcholinesterase (AChE) activity, which is one of the factors leading to neurodegeneration in AD. The aim of this study was to assess in vitro the effects of metformin, phenformin, and metformin sulfenamide prodrugs on the activity of human AChE and butyrylcholinesterase (BuChE) and establish the type of inhibition...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28754950/development-of-hydroxybenzoic-based-platforms-as-a-solution-to-deliver-dietary-antioxidants-to-mitochondria
#9
José Teixeira, Catarina Oliveira, Ricardo Amorim, Fernando Cagide, Jorge Garrido, José A Ribeiro, Carlos M Pereira, António F Silva, Paula B Andrade, Paulo J Oliveira, Fernanda Borges
Oxidative stress and mitochondrial dysfunction have been associated with metabolic and age-related diseases. Thus, the prevention of mitochondrial oxidative damage is nowadays a recognized pharmacological strategy to delay disease progression. Epidemiological studies suggested an association between the consumption of polyphenol-rich diet and the prevention of different pathologies, including diseases with a mitochondrial etiology. The development of mitochondrial-targeted antioxidants based on dietary antioxidants may decrease mitochondrial oxidative damage...
July 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28738351/major-depression-as-a-neuroprogressive-prelude-to-dementia-what-is-the-evidence
#10
Brian E Leonard
Epidemiological studies implicate chronic depression as a predisposing factor for dementia in later life. However, the link is incompletely understood and controversial. The aim of this review is to consider some of the biological factors that contribute to neuroprogressive brain dysfunction in late life as a consequence of prolonged, low-grade inflammation in the course of depressive episodes. As chronic inflammation is known to precipitate increased apoptosis of neurons and astrocytes, this could be a contributing factor to brain dysfunction...
2017: Modern Trends in Pharmacopsychiatry
https://www.readbyqxmd.com/read/28735838/cardiovascular-effects-of-air-pollution
#11
REVIEW
Thomas Bourdrel, Marie-Abèle Bind, Yannick Béjot, Olivier Morel, Jean-François Argacha
Air pollution is composed of particulate matter (PM) and gaseous pollutants, such as nitrogen dioxide and ozone. PM is classified according to size into coarse particles (PM10), fine particles (PM2.5) and ultrafine particles. We aim to provide an original review of the scientific evidence from epidemiological and experimental studies examining the cardiovascular effects of outdoor air pollution. Pooled epidemiological studies reported that a 10μg/m(3) increase in long-term exposure to PM2.5 was associated with an 11% increase in cardiovascular mortality...
July 20, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28733900/the-putative-role-of-environmental-mercury-in-the-pathogenesis-and-pathophysiology-of-autism-spectrum-disorders-and-subtypes
#12
REVIEW
G Morris, B K Puri, R E Frye, M Maes
Exposure to organic forms of mercury has the theoretical capacity to generate a range of immune abnormalities coupled with chronic nitro-oxidative stress seen in children with autism spectrum disorder (ASD). The paper discusses possible mechanisms explaining the neurotoxic effects of mercury and possible associations between mercury exposure and ASD subtypes. Environmental mercury is neurotoxic at doses well below the current reference levels considered to be safe, with evidence of neurotoxicity in children exposed to environmental sources including fish consumption and ethylmercury-containing vaccines...
July 22, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28731859/air-pollution-and-parkinson-s-disease-evidence-and-future-directions
#13
REVIEW
Natalia Palacios
Parkinson's disease (PD) is a neurodegenerative disease of unknown etiology that is thought to be caused by a complex combination of environmental and/or genetic factors. Air pollution exposure is linked to numerous adverse effects on human health, including brain inflammation and oxidative stress, processes that are believed to contribute to the development and progression of PD. This review provides an overview of recent advances in the epidemiology of air pollution and PD, including evidence of the effects of various pollutants (ozone, PM10, PM2...
July 21, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28715389/extraction-and-purification-of-polyphenols-from-freeze-dried-berry-powder-for-the-treatment-of-vascular-smooth-muscle-cells-in-vitro
#14
Rafaela G Feresin, Shirin Pourafshar, Jingwen Huang, Yitong Zhao, Bahram H Arjmandi, Gloria Salazar
Epidemiological studies indicate that increased flavonoid intake correlates with decreased mortality due to cardiovascular diseases (CVD) in the United States (US) and Europe. Berries are widely consumed in the US and have a high polyphenolic content. Polyphenols have been shown to interact with many molecular targets and to exert numerous positive biological functions, including antioxidant, anti-inflammatory, and cardioprotective effects. Polyphenols isolated from blackberry (BL), raspberry (RB), and black raspberry (BRB) reduce oxidative stress and cellular senescence in response to angiotensin II (Ang II)...
July 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28709031/bisphenol-a-induces-cox-2-through-the-mitogen-activated-protein-kinase-pathway-and-is-associated-with-levels-of-inflammation-related-markers-in-elderly-populations
#15
Heewon Song, Joonwoo Park, Phuong T C Bui, KeunOh Choi, Myung Chan Gye, Yun-Chul Hong, Jin Hee Kim, Young Joo Lee
Bisphenol A (BPA) is a well-known endocrine-disrupting chemical, and it is one of the highest volume chemicals produced worldwide. Even though several in vivo and in vitro studies showed positive associations of BPA exposure with pro-inflammatory cytokines such as tumor necrosis factor-α and interleukin (IL)-6, the mechanism by which BPA induces inflammation is unclear. We investigated the mechanism by which BPA induces inflammation (expression of inflammation-related genes, changes in oxidative stress, and cell proliferation and migration) and evaluated the effect of BPA exposure on inflammation-related markers in epidemiologic studies using repeat urine and serum samples from elderly subjects...
July 11, 2017: Environmental Research
https://www.readbyqxmd.com/read/28697312/proteome-analysis-of-irradiated-endothelial-cells-reveals-persistent-alteration-in-protein-degradation-and-the-rhogdi-and-no-signalling-pathways
#16
Omid Azimzadeh, Vikram Subramanian, Susanne Ständer, Juliane Merl-Pham, Donna Lowe, Zarko Barjaktarovic, Simone Moertl, Ken Raj, Michael J Atkinson, Soile Tapio
PURPOSE: Epidemiological studies indicate that radiation doses as low as 0.5 Gy increase the risk of cardiovascular disease decades after the exposure. The aim of the present study was to investigate whether this radiation dose causes late molecular alterations in endothelial cells that could support the population-based data. MATERIALS AND METHODS: Human coronary artery endothelial cells were irradiated at 0.5 Gy (X-ray) and radiation-induced changes in the proteome were investigated after different time intervals (1, 7 and 14 d) using ICPL technology...
July 11, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/28678931/vascular-aging-and-arterial-stiffness
#17
Luana de Rezende Mikael, Anelise Machado Gomes de Paiva, Marco Mota Gomes, Ana Luiza Lima Sousa, Paulo César Brandão Veiga Jardim, Priscila Valverde de Oliveira Vitorino, Maicon Borges Euzébio, Wátila de Moura Sousa, Weimar Kunz Sebba Barroso
Cardiovascular diseases (CVD) account annually for almost one third of all deaths worldwide. Among the CVD, systemic arterial hypertension (SAH) is related to more than half of those outcomes. Type 2 diabetes mellitus is an independent risk factor for SAH because it causes functional and structural damage to the arterial wall, leading to stiffness. Several studies have related oxidative stress, production of free radicals, and neuroendocrine and genetic changes to the physiopathogenesis of vascular aging. Indirect ways to analyze that aging process have been widely studied, pulse wave velocity (PWV) being considered gold standard to assess arterial stiffness, because there is large epidemiological evidence of its predictive value for cardiovascular events, and it requires little technical knowledge to be performed...
June 29, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28676088/parasitological-and-biochemical-studies-on-cutaneous-leishmaniasis-in-shara-b-district-taiz-yemen
#18
Qhtan Asmaa, Salwa Al-Shamerii, Mohammed Al-Tag, Adam Al-Shamerii, Yiping Li, Bashir H Osman
BACKGROUND: The leishmaniasis is a group of diseases caused by intracellular haemoflagellate protozoan parasites of the genus Leishmania. Leishmaniasis has diverse clinical manifestations; cutaneous leishmaniasis (CL) is the most common form of leishmaniasis which is responsible for 60% of disability-adjusted life years. CL is endemic in Yemen. In Shara'b there is no reference study available to identify the prevalence of endemic diseases and no investigation has been conducted for diagnosing the diseases...
July 4, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28669628/role-of-oxidative-stress-in-cardiovascular-disease-outcomes-following-exposure-to-ambient-air-pollution
#19
REVIEW
Frank J Kelly, Julia C Fussell
Exposure to ambient air pollution is associated with adverse cardiovascular outcomes. These are manifested through several, likely overlapping, pathways including at the functional level, endothelial dysfunction, atherosclerosis, pro-coagulation and alterations in autonomic nervous system balance and blood pressure. At numerous points within each of these pathways, there is potential for cellular oxidative imbalances to occur. The current review examines epidemiological, occupational and controlled exposure studies and research employing healthy and diseased animal models, isolated organs and cell cultures in assessing the importance of the pro-oxidant potential of air pollution in the development of cardiovascular disease outcomes...
June 29, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28664509/hypertension-induced-synapse-loss-and-impairment-in-synaptic-plasticity-in-the-mouse-hippocampus-mimics-the-aging-phenotype-implications-for-the-pathogenesis-of-vascular-cognitive-impairment
#20
Zsuzsanna Tucsek, M Noa Valcarcel-Ares, Stefano Tarantini, Andriy Yabluchanskiy, Gábor Fülöp, Tripti Gautam, Albert Orock, Anna Csiszar, Ferenc Deak, Zoltan Ungvari
Strong epidemiological and experimental evidence indicates that hypertension has detrimental effects on the cerebral microcirculation and thereby promotes accelerated brain aging. Hypertension is an independent risk factor for both vascular cognitive impairment (VCI) and Alzheimer's disease (AD). However, the pathophysiological link between hypertension-induced cerebromicrovascular injury (e.g., blood-brain barrier disruption, increased microvascular oxidative stress, and inflammation) and cognitive decline remains elusive...
June 29, 2017: GeroScience
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