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https://www.readbyqxmd.com/read/29779059/youth-responses-to-school-shootings-a-review
#1
REVIEW
Áine Travers, Tracey McDonagh, Ask Elklit
PURPOSE OF REVIEW: This paper aims to synthesize research relating to youth responses to school shootings between 2014 and 2017. The main questions it addresses are how such events impact young people psychologically, and what risk or protective factors may contribute to different trajectories of recovery? RECENT FINDINGS: Recent research suggests that most young people exposed to school shootings demonstrate resilience, exhibiting no long-term dysfunction. However, a minority will experience severe and chronic symptoms...
May 19, 2018: Current Psychiatry Reports
https://www.readbyqxmd.com/read/29775484/pseudomonas-aeruginosa-type-iv-minor-pilins-and-pily1-regulate-virulence-by-modulating-fims-algr-activity
#2
Victoria A Marko, Sara L N Kilmury, Lesley T MacNeil, Lori L Burrows
Type IV pili are expressed by a wide range of prokaryotes, including the opportunistic pathogen Pseudomonas aeruginosa. These flexible fibres mediate twitching motility, biofilm maturation, surface adhesion, and virulence. The pilus is composed mainly of major pilin subunits while the low abundance minor pilins FimU-PilVWXE and the putative adhesin PilY1 prime pilus assembly and are proposed to form the pilus tip. The minor pilins and PilY1 are encoded in an operon that is positively regulated by the FimS-AlgR two-component system...
May 18, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29766499/optimal-timing-of-physician-visits-after-hospital-discharge-to-reduce-readmission
#3
Bruno D Riverin, Erin C Strumpf, Ashley I Naimi, Patricia Li
OBJECTIVE: To identify the optimal timing of in-person physician visit after hospital discharge to yield the largest reduction in readmission among elderly or chronically ill patients. DATA SOURCES/STUDY SETTING/EXTRACTION METHODS: We extracted insurance billing data on 620,656 admissions for any cause from 2002 to 2009 in Quebec, Canada. STUDY DESIGN: We used flexible survival models to estimate inverse probability weights for the precise timing (days) of in-person physician visit after discharge and weighted competing risk outcome models...
May 15, 2018: Health Services Research
https://www.readbyqxmd.com/read/29759012/using-the-replicating-effective-programs-framework-to-adapt-a-heart-health-intervention
#4
Jessica E Ramsay, Mary R Janevic, Cainnear K Hogan, Dominique L Edwards, Cathleen M Connell
Heart disease is the leading cause of death in the United States. African Americans and people of low socioeconomic status suffer disproportionately from heart disease-related morbidity and mortality. In Detroit, Michigan, a primarily African American and low-income urban area, heart disease mortality is at twice the national rate. Despite evidence for the effectiveness of self-management support interventions in reducing chronic disease burden for older adults, few are adapted for communities most in need...
May 1, 2018: Health Promotion Practice
https://www.readbyqxmd.com/read/29754331/cellular-stress-responses-to-chronic-heat-shock-and-shell-damage-in-temperate-mya-truncata
#5
Victoria A Sleight, Lloyd S Peck, Elisabeth A Dyrynda, Valerie J Smith, Melody S Clark
Acclimation, via phenotypic flexibility, is a potential means for a fast response to climate change. Understanding the molecular mechanisms underpinning phenotypic flexibility can provide a fine-scale cellular understanding of how organisms acclimate. In the last 30 years, Mya truncata populations around the UK have faced an average increase in sea surface temperature of 0.7 °C and further warming of between 1.5 and 4 °C, in all marine regions adjacent to the UK, is predicted by the end of the century...
May 12, 2018: Cell Stress & Chaperones
https://www.readbyqxmd.com/read/29753941/an-integrated-computational-approach-of-molecular-dynamics-simulations-receptor-binding-studies-and-pharmacophore-mapping-analysis-in-search-of-potent-inhibitors-against-tuberculosis
#6
Shivangi Agarwal, Ekta Verma, Vivek Kumar, Namrita Lall, Samaresh Sau, Arun K Iyer, Sushil K Kashaw
Tuberculosis is an infectious chronic disease caused by obligate pathogen Mycobacterium tuberculosis that affects millions of people worldwide. Although many first and second line drugs are available for its treatment, but their irrational use has adversely lead to the emerging cases of multiple drug resistant and extensively drug-resistant tuberculosis. Therefore, there is an intense need to develop novel potent analogues for its treatment. This has prompted us to develop potent analogues against TB. The Mycobacterium tuberculosis genome provides us with number of validated targets to combat against TB...
May 3, 2018: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29743563/cell-therapy-trials-for-heart-regeneration-lessons-learned-and-future-directions
#7
REVIEW
Philippe Menasché
The effects of cell therapy on heart regeneration in patients with chronic cardiomyopathy have been assessed in several clinical trials. These trials can be categorized as those using noncardiac stem cells, including mesenchymal stem cells, and those using cardiac-committed cells, including KIT+ cardiac stem cells, cardiosphere-derived cells, and cardiovascular progenitor cells derived from embryonic stem cells. Although the safety of cell therapies has been consistently reported, their efficacy remains more elusive...
May 9, 2018: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29743496/complex-housing-causes-a-robust-increase-in-dendritic-complexity-and-spine-density-of-medial-prefrontal-cortical-neurons
#8
Archana Ashokan, Jamien Wee Han Lim, Nicholas Hang, Rupshi Mitra
Prelimbic cortex and infralimbic cortex, parts of the ventromedial prefrontal cortex, are critical brain regions for generating a flexible behavioral response to changing environmental contingencies. This includes the role of these brain structures in the extinction of learned fear, decision making and retrieval of remote memories. Dendritic structure of medial prefrontal cortex neurons retains significant structural plasticity in adulthood. This has been mainly demonstrated as dendritic atrophy and loss of dendritic spines due to chronic stress...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740308/cyclosporin-a-mediated-activation-of-endogenous-neural-precursor-cells-promotes-cognitive-recovery-in-a-mouse-model-of-stroke
#9
Labeeba Nusrat, Jessica M Livingston-Thomas, Vaakiny Raguthevan, Kelsey Adams, Ilan Vonderwalde, Dale Corbett, Cindi M Morshead
Cognitive dysfunction following stroke significantly impacts quality of life and functional independance; yet, despite the prevalence and negative impact of cognitive deficits, post-stroke interventions almost exclusively target motor impairments. As a result, current treatment options are limited in their ability to promote post-stroke cognitive recovery. Cyclosporin A (CsA) has been previously shown to improve post-stroke functional recovery of sensorimotor deficits. Interestingly, CsA is a commonly used immunosuppressant and also acts directly on endogenous neural precursor cells (NPCs) in the neurogenic regions of the brain (the periventricular region and the dentate gyrus)...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29739457/key-features-of-palliative-care-service-delivery-to-indigenous-peoples-in-australia-new-zealand-canada-and-the-united-states-a-comprehensive-review
#10
Shaouli Shahid, Emma V Taylor, Shelley Cheetham, John A Woods, Samar M Aoun, Sandra C Thompson
BACKGROUND: Indigenous peoples in developed countries have reduced life expectancies, particularly from chronic diseases. The lack of access to and take up of palliative care services of Indigenous peoples is an ongoing concern. OBJECTIVES: To examine and learn from published studies on provision of culturally safe palliative care service delivery to Indigenous people in Australia, New Zealand (NZ), Canada and the United States of America (USA); and to compare Indigenous peoples' preferences, needs, opportunities and barriers to palliative care...
May 8, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29736198/optimism-positive-and-negative-affect-and-goal-adjustment-strategies-their-relationship-to-activity-patterns-in-patients-with-chronic-musculoskeletal-pain
#11
Rosa Esteve, Alicia E López-Martínez, Madelon L Peters, Elena R Serrano-Ibáñez, Gema T Ruiz-Párraga, Carmen Ramírez-Maestre
Objective: Activity patterns are the product of pain and of the self-regulation of current goals in the context of pain. The aim of this study was to investigate the association between goal management strategies and activity patterns while taking into account the role of optimism/pessimism and positive/negative affect. Methods: Two hundred and thirty-seven patients with chronic musculoskeletal pain filled out questionnaires on optimism, positive and negative affect, pain intensity, and the activity patterns they employed in dealing with their pain...
2018: Pain Research & Management: the Journal of the Canadian Pain Society
https://www.readbyqxmd.com/read/29726743/opinion-paper-the-role-of-work-in-the-management-of-medically-unexplained-physical-symptoms
#12
Els Tobback, An Mariman, Lies Clauwaert, Lode Godderis, Stefan Heytens, Patrick Ruppol, Daniel Spooren, Rita Tytgat, Martine De Muynck, Dirk Vogelaers
OBJECTIVES: Patients with medically unexplained physical symptoms suffer from chronic fatigue and/or pain in combination with a variety of other symptoms. A flexible, biopsychosocial approach is needed for diagnostic screening and global management. It is crucial to involve the direct patient environment, including family, friends, colleagues as well as health providers, evaluation, and reintegration sector. The aim of this paper is to review the importance of work in the management of medically unexplained physical symptoms...
May 4, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29720873/the-impact-on-quality-of-life-of-dialysis-patients-with-renal-insufficiency
#13
Marta Dąbrowska-Bender, Grażyna Dykowska, Wioletta Żuk, Magdalena Milewska, Anna Staniszewska
Aim: The aim of the study was the subjective assessment of the quality of life (QoL) of 140 patients treated with dialysis (peritoneal dialysis and hemodialysis). Background: Chronic kidney disease and the methods of its treatment play an important part in shaping the QoL of patients receiving dialysis. As a result, kidney failure causes many limitations in patients' physical, mental, and social activities. Methods: The instrument to measure the QoL was the authors' own questionnaire made on the basis of Kidney Disease and Quality of Life Short Form version 1...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29706024/overexpression-of-cyb5r3-and-nqo1-two-nad-producing-enzymes-mimics-aspects-of-caloric-restriction
#14
Alberto Diaz-Ruiz, Michael Lanasa, Joseph Garcia, Hector Mora, Frances Fan, Alejandro Martin-Montalvo, Andrea Di Francesco, Miguel Calvo-Rubio, Andrea Salvador-Pascual, Miguel A Aon, Kenneth W Fishbein, Kevin J Pearson, Jose Manuel Villalba, Placido Navas, Michel Bernier, Rafael de Cabo
Calorie restriction (CR) is one of the most robust means to improve health and survival in model organisms. CR imposes a metabolic program that leads to increased stress resistance and delayed onset of chronic diseases, including cancer. In rodents, CR induces the upregulation of two NADH-dehydrogenases, namely NAD(P)H:quinone oxidoreductase 1 (Nqo1) and cytochrome b5 reductase 3 (Cyb5r3), which provide electrons for energy metabolism. It has been proposed that this upregulation may be responsible for some of the beneficial effects of CR, and defects in their activity are linked to aging and several age-associated diseases...
April 28, 2018: Aging Cell
https://www.readbyqxmd.com/read/29704880/feasibility-randomized-controlled-trial-of-online-acceptance-and-commitment-therapy-for-patients-with-complex-chronic-pain-in-the-united-kingdom
#15
Whitney Scott, Joseph Chilcot, Beth Guildford, Aisling Daly-Eichenhardt, Lance M McCracken
BACKGROUND: Acceptance and Commitment Therapy (ACT) has growing support for chronic pain. However, more accessible treatment delivery is needed. This study evaluated the feasibility of online ACT for patients with complex chronic pain in the United Kingdom to determine whether a larger trial is justified. METHODS: Participants with chronic pain and clinically-meaningful disability and distress were randomly assigned to ACT online plus specialty medical pain management, or specialty medical management alone...
April 28, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29696732/seshat-a-web-service-for-accurate-annotation-validation-and-analysis-of-tp53-variants-generated-by-conventional-and-next-generation-sequencing
#16
Tuomas Tikkanen, Bernard Leroy, Jean Louis Fournier, Rosa Ana Risques, Jitka Malcikova, Thierry Soussi
Accurate annotation of genomic variants in human diseases is essential to allow personalized medicine. Assessment of somatic and germline TP53 alterations has now reached the clinic and is required in several circumstances such as the identification of the most effective cancer therapy for patients with chronic lymphocytic leukemia (CLL). Here we present Seshat, a web service for annotating TP53 information derived from sequencing data. A flexible framework allows the use of standard file formats such as Mutation Annotation Format (MAF) or Variant Call Format (VCF), as well as common TXT files...
April 25, 2018: Human Mutation
https://www.readbyqxmd.com/read/29692860/the-long-term-outcome-of-patients-with-heroin-use-disorder-dual-disorder-chronic-psychosis-after-admission-to-enhanced-methadone-maintenance
#17
Angelo G I Maremmani, Alessandro Pallucchini, Luca Rovai, Silvia Bacciardi, Vincenza Spera, Marco Maiello, Giulio Perugi, Icro Maremmani
Background: Over-standard methadone doses are generally needed in the treatment of heroin use disorder (HUD) patients that display concomitant high-severity psychopathological symptomatology. A flexible dosing regimen may lead to higher retention rates in dual disorder (DD), as we demonstrated in bipolar 1 HUD patients, leading to outcomes that are as satisfactory as those of HUD patients without high-severity psychopathological symptomatology. Objective: This study aimed to compare the long-term outcomes of treatment-resistant chronic psychosis HUD patients (PSY-HUD) with those of peers without dual disorder (HUD)...
2018: Annals of General Psychiatry
https://www.readbyqxmd.com/read/29690870/palliative-care-for-homeless-people-a-systematic-review-of-the-concerns-care-needs-and-preferences-and-the-barriers-and-facilitators-for-providing-palliative-care
#18
Hanna T Klop, Anke J E de Veer, Sophie I van Dongen, Anneke L Francke, Judith A C Rietjens, Bregje D Onwuteaka-Philipsen
BACKGROUND: Homeless people often suffer from complex and chronic comorbidities, have high rates of morbidity and die at much younger ages than the general population. Due to a complex combination of physical, psychosocial and addiction problems at the end of life, they often have limited access to palliative care. Both the homeless and healthcare providers experience a lot of barriers. Therefore, providing palliative care that fits the needs and concerns of the homeless is a challenge to healthcare providers...
April 24, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29688639/-children-with-attention-deficit-hyperactivity-disorder-adhd-clinical-activity-in-israel
#19
Yuval Bloch
This editorial relates to the study published in the current issue on how our current knowledge is practiced in screening, diagnosing and treating children suffering from ADHD in Israel. It seems that there is an awareness of the disorder by parents and teachers, thus there is no need for community screening. The roles of the different medical professions: pediatricians (after receiving training on ADHD), child neurologists and child psychiatrists are not clear enough and thus services are not utilized properly...
April 2018: Harefuah
https://www.readbyqxmd.com/read/29685875/identifying-subgroups-of-patients-with-chronic-nonspecific-low-back-pain-based-on-a-multifactorial-approach-protocol-for-a-prospective-study
#20
Kevin Rose-Dulcina, Nicolas Vuillerme, Anne Tabard-Fougère, Romain Dayer, Dennis E Dominguez, Stephane Armand, Stéphane Genevay
BACKGROUND: Low back pain, especially nonspecific chronic low back pain (LBP), the leading cause of disability worldwide, represents both social and economic problems. Different therapeutic management techniques can be used, but their effects vary. Clinicians and researchers attribute the variation in the efficacy of therapeutic and management techniques to the heterogeneity of the nonspecific chronic low back pain population, and they agree that nonspecific chronic LBP must be subgrouped...
April 23, 2018: JMIR Research Protocols
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