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https://www.readbyqxmd.com/read/29334292/safety-and-effectiveness-of-fascial-therapy-in-adult-patients-with-hemophilic-arthropathy-a-pilot-study
#1
Elena Donoso-Úbeda, Javier Meroño-Gallut, José Antonio López-Pina, Rubén Cuesta-Barriuso
BACKGROUND: The primary clinical manifestations of hemophilia are muscle and joint bleeding. Recurrent bleeding leads to a degenerative process known as hemophilic arthropathy. Fascial therapy is one of the most used physiotherapy techniques today to improve joint dysfunctions and chronic pain. OBJECTIVE: To assess the safety and efficacy of fascial therapy treatment in patients with hemophilic arthropathy of ankle and knee. DESIGN: Non-randomized, controlled clinical trial...
January 15, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29333588/nitrogen-fixation-activity-and-the-abundance-and-taxonomy-of-nifh-genes-in-agricultural-pristine-and-urban-prairie-stream-sediments-chronically-exposed-to-different-levels-of-nitrogen-loading
#2
Ingrid R Caton, Todd M Caton, Mark A Schneegurt
Small streams exert great influences on the retention and attenuation of nitrogen (N) within stream networks. Human land use can lead to increased transport of dissolved inorganic N compounds and downstream eutrophication. Microbial activity in streams is important for maintaining an actively functioning N cycle. Chronically high N loading in streams affects the rates of the central processes of the N cycle by increasing rates of nitrification and denitrification, with biota exhibiting decreased efficiency of N use...
January 15, 2018: Archives of Microbiology
https://www.readbyqxmd.com/read/29325229/dual-drug-targeting-of-mutant-bcr-abl-induces-inactive-conformation-new-strategy-for-the-treatment-of-chronic-myeloid-leukemia-and-overcoming-monotherapy-resistance
#3
Ahmed A El Rashedy, Fisayo A Olotu, Mahmoud E S Soliman
Bcr-Abl is an oncogenic fusion protein which expression enhances tumorigenesis, and has been highly associated with chronic myeloid leukemia (CML). Acquired drug resistance in mutant Bcr-Abl has enhanced pathogenesis with the use of single therapy agents such as Nilotinib. Moreover, allosteric targeting has been identified to consequentially inhibit Bcr-Abl activity, which led to the recent development of ABL-001 (asciminib) that selectively binds the myristoyl pocket. Experimental studies have revealed that the combination of Nilotinib and ABL-001 induced a "bent" conformation in the C-terminal helix of Bcr-Abl; a benchmark of inhibition, thereby exhibiting a greater potency in the treatment of CML, surmounting the setbacks of drug resistance, disease regression and relapse...
January 11, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29323395/self-powered-implantable-electronic-skin-for-in-situ-analysis-of-urea-uric-acid-in-body-fluids-and-the-potential-applications-in-real-time-kidney-disease-diagnosis
#4
Wenyan Yang, Wuxiao Han, Huiling Gao, Linlin Zhang, Shuai Wang, Lili Xing, Yan Zhang, Xinyu Xue
As the concentration of different biomarkers in human body fluids are an important parameter of chronic disease, wearable biosensors for in situ analysis of body fluids with high sensitivity, real-time detection, flexibility and biocompatibility have significant potential therapeutic applications. In this paper, a flexible self-powered implantable electronic-skin (e-skin) for in situ body fluids analysis (urea/uric-acid) as a real-time kidney-disease diagnoser has been proposed based on the piezo-enzymatic-reaction coupling process of ZnO nanowire arrays...
January 11, 2018: Nanoscale
https://www.readbyqxmd.com/read/29320375/psychological-flexibility-mediates-the-effect-of-an-online-based-acceptance-and-commitment-therapy-for-chronic-pain-an-investigation-of-change-processes
#5
Jiaxi Lin, Laura-Isabelle Klatt, Lance M McCracken, Harald Baumeister
One way to improve treatment effects of chronic pain is to identify and improve control over mechanisms of therapeutic change. One treatment approach that includes a specific proposed mechanism is acceptance and commitment therapy (ACT) with its focus on increasing psychological flexibility (PF). The aim of the present study was to examine the role of PF as a mechanism of change in ACT. This is based on mediation analyses of data from a previously reported randomized controlled trial, evaluating the effectiveness of an ACT-based online intervention for chronic pain (ACTonPain)...
December 15, 2017: Pain
https://www.readbyqxmd.com/read/29311001/up-to-date-and-projected-estimates-of-survival-for-people-with-cystic-fibrosis-using-baseline-characteristics-a-longitudinal-study-using-uk-patient-registry-data
#6
Ruth H Keogh, Rhonda Szczesniak, David Taylor-Robinson, Diana Bilton
BACKGROUND: Cystic fibrosis (CF) is the most common inherited disease in Caucasians, affecting around 10,000 individuals in the UK today. Prognosis has improved considerably over recent decades with ongoing improvements in treatment and care. Providing up-to-date survival predictions is important for patients, clinicians and health services planning. METHODS: Flexible parametric survival modelling of UK CF Registry data from 2011 to 2015, capturing 602 deaths in 10,428 individuals...
January 5, 2018: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
https://www.readbyqxmd.com/read/29310746/nurse-practitioner-s-perceptions-of-the-impact-of-the-nurse-practitioner-led-clinic-model-on-the-quality-of-care-of-complex-patients
#7
Roberta Heale, Susan James, Elizabeth Wenghofer, Marie-Luce Garceau
Aim To evaluate the organizational processes that influence the quality of care for patients with multimorbidity at nurse practitioner-led clinics (NPLCs). BACKGROUND: People are living longer, most with one or more chronic diseases (mulitmorbidity) and primary healthcare for these patients has become increasingly complex. One response was the establishment of new models of primary healthcare. NPLCs are an example of a model developed in Ontario, Canada, which feature nurse practitioners as the primary care providers practicing within an interprofessional team...
January 9, 2018: Primary Health Care Research & Development
https://www.readbyqxmd.com/read/29301561/exploring-narratives-of-resilience-among-seven-males-living-with-spinal-cord-injury-a-qualitative-study
#8
Anne Geard, Marit Kirkevold, Marianne Løvstad, Anne-Kristine Schanke
BACKGROUND: It is a challenge for both individuals and families when an illness or traumatic injury results in a severe spinal cord injury. The on-going physical impairments experienced by persons with spinal cord injury play themselves out over time. Few qualitative studies have explored how health, resilience and wellbeing interplay across time among persons living with the consequences of severe physical injuries. Thus, the aim of this study was to obtain a deeper understanding of how individuals with spinal cord injury reflect upon the efforts, strategies and agency they perform to sustain long term resilience and wellbeing...
January 4, 2018: BMC Psychology
https://www.readbyqxmd.com/read/29289308/creasensor-simple-technology-for-creatinine-detection-in-plasma
#9
Francesco Dal Dosso, Deborah Decrop, Elena Pérez-Ruiz, Devin Daems, Hannah Agten, Osamah Al-Ghezi, Olivier Bollen, Jolien Breukers, Florian De Rop, Maria Katsafadou, Jens Lepoudre, Linye Lyu, Pieter Piron, Robbe Saesen, Shoera Sels, Rani Soenen, Ellen Staljanssens, Jehan Taraporewalla, Tadej Kokalj, Dragana Spasic, Jeroen Lammertyn
The lab-on-a-chip (LOC) field has witnessed an excess of new technology concepts, especially for the point-of-care (POC) applications. However, only few concepts reached the POC market often because of challenging integration with pumping and detection systems as well as with complex biological assays. Recently, a new technology termed SIMPLE was introduced as a promising POC platform due to its features of being self-powered, autonomous in liquid manipulations, cost-effective and amenable to mass production...
February 13, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29286468/analysis-of-immune-cells-in-single-sciatic-nerves-and-dorsal-root-ganglion-from-a-single-mouse-using-flow-cytometry
#10
Asa S Hidmark, Peter P Nawroth, Thomas Fleming
Nerve-resident immune cells in the peripheral nervous system (PNS) are essential to maintaining neuronal integrity in a healthy nerve. The immune cells of the PNS are affected by injury and disease, affecting the nerve function and the capacity for regeneration. Neuronal immune cells are commonly analyzed by immunofluorescence (IF). While IF is essential for determining the location of the immune cells in the nerve, IF is only semi-quantitative and the method is limited to the number of markers that can be analyzed simultaneously and the degree of surface expression...
December 6, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29283590/tutorial-the-practical-application-of-longitudinal-structural-equation-mediation-models-in-clinical-trials
#11
Kimberley A Goldsmith, David P MacKinnon, Trudie Chalder, Peter D White, Michael Sharpe, Andrew Pickles
The study of mediation of treatment effects, or how treatments work, is important to understanding and improving psychological and behavioral treatments, but applications often focus on mediators and outcomes measured at a single time point. Such cross-sectional analyses do not respect the implied temporal ordering that mediation suggests. Clinical trials of treatments often provide repeated measures of outcomes and, increasingly, of mediators as well. Repeated measurements allow the application of various types of longitudinal structural equation mediation models...
December 28, 2017: Psychological Methods
https://www.readbyqxmd.com/read/29259809/the-addition-of-a-tension-night-splint-to-a-structured-home-rehabilitation-programme-in-patients-with-chronic-plantar-fasciitis-does-not-lead-to-significant-additional-benefits-in-either-pain-function-or-flexibility-a-single-blinded-randomised-controlled-trial
#12
Patrick C Wheeler
Objective: To identify any improvements in pain or function in patients with chronic plantar fasciitis following the use of a tension night splint (TNS). Methods: Single-blinded randomised controlled trial, with participants split evenly between intervention group (TNS + home exercise programme/HEP) and control group (HEP only). Follow-up at 3 months, with interim data at 6 weeks. Results: 40 patients recruited. Mean age 52.1 years, 33% male, mean body mass index 30...
2017: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29258742/projections-of-health-indicators-for-chronic-disease-under-a-semi-markov-assumption
#13
REVIEW
Mathilde Wanneveich, Hélène Jacqmin-Gadda, Jean-François Dartigues, Pierre Joly
Chronic diseases are a growing public health problem due to the population aging. Their economic, social and demographic burden will worsen in years to come. Up to now, the method used to provide projections and assess the future disease burden makes a non-homogeneous Markov assumption in an illness-death model. Both age and calendar year have been taken into account in all parameter estimations, but the time spent with the disease was not considered. This work develops the method with a semi-Markov assumption to model mortality among the diseased and considering the time spent with the disease...
December 16, 2017: Theoretical Population Biology
https://www.readbyqxmd.com/read/29251778/advance-care-planning-acp-for-specialists-managing-cirrhosis-a-focus-on-patient-centered-care
#14
REVIEW
Amanda Brisebois, Kathleen P Ismond, Michelle Carbonneau, Puneeta Tandon
Advance care planning (ACP) and goals of care designation (GCD) are being integrated into modern health care. In cirrhosis, uptake and adoption of these practices have been limited with physicians citing many perceived barriers and limitations. Recognizing the many tangible benefits of ACP and GCD processes in patients with life-limiting chronic diseases, the onus is on health practitioners to initiate and direct these conversations with their patients and surrogates. Drawing upon the literature and our experiences in palliative care and cirrhosis, we provide an actionable framework that can be readily implemented into a busy clinic setting by a practitioner...
December 18, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29248158/the-role-of-left-insula-in-executive-set-switching-lesion-evidence-from-an-acute-stroke-cohort
#15
Andreja Varjačić, Dante Mantini, Jacob Levenstein, Elitsa D Slavkova, Nele Demeyere, Céline R Gillebert
Impairments in executive functions are common in stroke survivors, both in the acute and in the chronic phase. However, little is known about the underlying lesion neuroanatomy of these deficits. This study aimed to elucidate the pattern of brain damage underlying executive dysfunction in a large and acute stroke cohort. Executive set-switching deficits were evaluated by a shape-based analogue of the Trail Making Test (from the Oxford Cognitive Screen) in a consecutive sample of 144 stroke patients (age: 70 ± 15 years, examination: 5 ± 4 days post-stroke; brain imaging: 1...
November 22, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29247044/stochasticity-enables-bcr-independent-germinal-center-initiation-and-antibody-affinity-maturation
#16
Jared Silver, Teng Zuo, Neha Chaudhary, Rupa Kumari, Pei Tong, Sophie Giguere, Alessandra Granato, Rakesh Donthula, Colby Devereaux, Duane R Wesemann
Two immunoglobulin (Ig) diversification mechanisms collaborate to provide protective humoral immunity. Combinatorial assembly of IgH and IgL V region exons from gene segments generates preimmune Ig repertoires, expressed as B cell receptors (BCRs). Secondary diversification occurs when Ig V regions undergo somatic hypermutation (SHM) and affinity-based selection toward antigen in activated germinal center (GC) B cells. Secondary diversification is thought to only ripen the antigen-binding affinity of Igs that already exist (i...
December 15, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/29241653/synaptic-adaptations-to-chronic-ethanol-intake-in-male-rhesus-monkey-dorsal-striatum-depend-on-age-of-drinking-onset
#17
Verginia C Cuzon Carlson, Kathleen A Grant, David M Lovinger
One in 12 adults suffer with alcohol use disorder (AUD). Studies suggest the younger the age in which alcohol consumption begins the higher the probability of being diagnosed with AUD. Binge/excessive alcohol drinking involves a transition from flexible to inflexible behavior likely involving the dorsal striatum (caudate and putamen nuclei). A major focus of this study was to examine the effect of age of drinking onset on subsequent chronic, voluntary ethanol intake and dorsal striatal circuitry. Data from rhesus monkeys (n = 45) that started drinking as adolescents, young adults or mature adults confirms an age-related risk for heavy drinking...
December 12, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/29241444/willingness-to-pay-for-flexible-working-conditions-of-people-with-type-2-diabetes-discrete-choice-experiments
#18
M A Nexo, B Cleal, Lise Hagelund, I Willaing, K Olesen
BACKGROUND: The increasing number of people with chronic diseases challenges workforce capacity. Type 2 diabetes (T2D) can have work-related consequences, such as early retirement. Laws of most high-income countries require workplaces to provide accommodations to enable people with chronic disabilities to manage their condition at work. A barrier to successful implementation of such accommodations can be lack of co-workers' willingness to support people with T2D. This study aimed to examine the willingness to pay (WTP) of people with and without T2D for five workplace initiatives that help individuals with type 2 diabetes manage their diabetes at work...
December 15, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29238574/role-of-guaifenesin-in-the-management-of-chronic-bronchitis-and-upper-respiratory-tract-infections
#19
REVIEW
Helmut H Albrecht, Peter V Dicpinigaitis, Eric P Guenin
Guaifenesin, a mucoactive drug, acts by loosening mucus in the airways and making coughs more productive. It is used for relief of wet cough and chest congestion due to the common cold, and remains the only legally marketed expectorant in the US (per OTC Monograph). An ingredient in numerous over-the-counter (OTC) cough/cold medications, guaifenesin has a secondary indication for use in stable chronic bronchitis (professional indication). Clinical pharmacology and patient studies support the clinical utility of guaifenesin in respiratory conditions where mucus hypersecretion is prevalent: acute upper respiratory tract infections (URTIs), stable chronic bronchitis, and possibly rhinosinusitis...
2017: Multidisciplinary Respiratory Medicine
https://www.readbyqxmd.com/read/29238497/the-role-of-anxiety-and-depression-on-acceptance-and-action-considering-emotional-schemas-in-diabetics-of-birjand-iran
#20
Elham Imani, Fatemeh Shahabizadeh, Alireza Mahmoodirad
Background: Diabetes is one of the most common noncommunicable diseases around the world that accompanies assorted psychiatric disorders including anxiety and depression due to being chronic. Objective: The aim of this study was to evaluate the effect of anxiety and depression on acceptance and action, considering emotional schemas of diabetics referring to diabetes clinics of health centers in Birjand, Iran. Methods: This study was conducted in 2016 and was a correlational study with a structural equation modeling approach...
October 2017: Electronic Physician
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