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hyperthermic intraperitoneal chemotherapy

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https://www.readbyqxmd.com/read/29678273/preoperative-ct-based-predictive-factors-for-resectability-and-medium-term-overall-survival-in-patients-with-peritoneal-carcinomatosis-from-colorectal-cancer
#1
C Suzuki, H Wallgren, M Abraham-Nordling, G Palmer
AIM: To determine preoperative radiological findings that may correlate with resectability and medium-term overall survival (OS) in patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC). MATERIALS AND METHODS: The study included 81 consecutive patients with PC scheduled for cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). PCI scores from preoperative computed tomography (CT) were compared with Peritoneal Cancer Index (PCI) scores at laparotomy...
April 17, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29675023/increased-plasma-levels-of-danger-associated-molecular-patterns-are-associated-with-immune-suppression-and-postoperative-infections-in-patients-undergoing-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#2
Guus P Leijte, Hettie Custers, Jelle Gerretsen, Amon Heijne, Johannes Roth, Thomas Vogl, Gert J Scheffer, Peter Pickkers, Matthijs Kox
Introduction: Danger-associated molecular patterns (DAMPs) can elicit immune responses and may subsequently induce an immune-suppressed state. Previous work showed that increased plasma levels of DAMPs are associated with immune suppression and increased susceptibility toward infections in trauma patients. Like trauma, major surgical procedures, such as cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC), are also thought to cause profound DAMP release...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29671139/treatment-of-isolated-peritoneal-recurrences-in-patients-with-colorectal-peritoneal-metastases-previously-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#3
Wijntje J van Eden, Fortuné M K Elekonawo, Bas J Starremans, Niels F M Kok, André J A Bremers, Johannes H W de Wilt, Arend G J Aalbers
BACKGROUND: Colorectal peritoneal carcinomatosis (PC) is preferably treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Peritoneal recurrence of disease after treatment can occur without distant metastases, with a variety of treatment options. OBJECTIVE: This study aimed to evaluate the management of isolated peritoneal recurrence after primary CRS-HIPEC. METHODS: In two tertiary referral centers, all patients who underwent CRS-HIPEC for colorectal PC between 2004 and 2015 and who developed isolated peritoneal recurrences were retrospectively evaluated...
April 18, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29667123/peritoneal-carcinomatosis-arising-from-rectal-or-colonic-adenocarcinoma-treated-with-cytoreductive-surgery-crs-hyperthermic-intraperitoneal-chemotherapy-hipec-two-different-diseases
#4
M Tonello, G Ortega-Perez, O Alonso-Casado, P Torres-Mesa, G Guiñez, S Gonzalez-Moreno
PURPOSE: Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) has poor survival. Multi-modal treatment including systemic chemotherapy, cytoreductive surgery (CRS), and hyperthermic intraperitoneal chemotherapy (HIPEC) can be used in selected patients with curative intent. The majority published works consider PC of CRC origin as a homogenous disease. Aim of this study is to stress the different biological behaviors and survival of PC according to colonic or rectal origin. METHODS: Data of CRS and HIPEC procedures for PC of CRC origin performed at MD Anderson Cancer Center-Madrid (Spain) have been collected, dividing patients into two groups according to colonic or rectal PC...
April 17, 2018: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29650418/inflammatory-bowel-disease-drastically-affects-the-prognosis-of-patients-treated-for-peritoneal-metastases-with-combined-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-a-multicenter-study
#5
Nassim Hammoudi, Clarisse Eveno, Jérôme Lambert, Marianne Maillet, Olivier Glehen, Diane Goere, Nelson Lourenco, Matthieu Allez, Thomas Aparicio, Marc Pocard, Jean-Marc Gornet
BACKGROUND: Complete cytoreductive surgery (CCRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a validated treatment in selected patients with peritoneal metastases (PM) of intestinal origin. There is an increased risk of Colorectal Cancer (CRC) and Small Bowel Adenocarcinoma (SBA) in Inflammatory Bowel Disease (IBD). The feasibility and benefit of that surgical approach in IBD patients is unknown. METHODS: IBD patients with operated PM complicating CRC or SBA were extracted from a French national multicenter prospective database of patients who underwent surgery for PM in HIPEC expert centers from 1995 to 2016...
March 17, 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29643552/anaesthetic-management-and-perioperative-outcomes-of-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy-a-retrospective-analysis
#6
Kalpana P Balakrishnan, Sreedevi Survesan
Background and Aims: Cytoreductive surgery (CRS) combined with hyperthermic intraperitoneal chemotherapy (HIPEC) is becoming the standard treatment option for peritoneal carcinomatosis but is associated with high rates of morbidity and mortality. Our aim was to retrospectively analyse and evaluate intra-operative factors associated with morbidity and mortality of CRS and HIPEC. Methods: Intra-operative data were collected for cases done over 1 year (24 cases) and analysed for the primary outcome of post-operative ventilation >24 h, and secondary outcome of length of the Intensive Care Unit (ICU) stay >5 days...
March 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29643548/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-fluid-and-temperature-remain-the-culprit
#7
EDITORIAL
Rakesh Garg
No abstract text is available yet for this article.
March 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29630093/comment-about-the-hyperthermic-intraoperative-intraperitoneal-chemotherapy-in-the-treatment-of-advanced-abdominopelvic-cancer-personal-experience-on-103-procedures-during-a-seventeen-year-period-in-a-single-italian-center
#8
R Fisichella, A Cappellani, S Berretta
No abstract text is available yet for this article.
March 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29626594/population-pharmacokinetics-of-oxaliplatin-after-intraperitoneal-administration-with-hyperthermia-in-wistar-rats
#9
M I Mas-Fuster, A Ramon-Lopez, F J Lacueva, A Arroyo, P Más-Serrano, R Nalda-Molina
BACKGROUND: The evaluation of the efficacy and toxicity of hyperthermic intraoperative peritoneal chemotherapy presents some difficulties, due in part to the lack of information about the pharmacokinetic behavior of the drugs administered in this procedure. The aim of this study was to characterize the population pharmacokinetics of hyperthermic intraoperative peritoneal oxaliplatin in Wistar rats and to evaluate the effect of treatment-related covariates dose, instillation time and temperature on the pharmacokinetic parameters...
April 4, 2018: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29624505/impact-of-concomitant-urologic-intervention-on-clinical-outcomes-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#10
Akshat Saxena, Winston Liauw, Sohaib A Virk, David L Morris
INTRODUCTION: The impact of concomitant urologic procedures (UPs) on perioperative and long-term outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is uncertain. METHODS: In total, 935 consecutive CRS/HIPEC procedures were performed between 1996 and 2016 in Sydney, Australia. Among these, 73 (7.8%) involved concomitant UP. The association of concomitant UP with 21 perioperative outcomes and overall survival was assessed using univariate and multivariate analyses...
April 5, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29616280/-surgical-treatment-of-peritoneal-metastases-of-gastric-cancer
#11
REVIEW
A Brandl, E Pachmayr, S Gül-Klein, M Alberto, P Thuss-Patience, B Rau
BACKGROUND: Up to 17% of all patients with gastric cancer are diagnosed with the presence of peritoneal metastases, which is associated with a poor prognosis. The most promising results were shown with multimodal treatment regimens including systemic chemotherapy and cytoreductive surgery (CRS). A subsequent hyperthermic intraperitoneal chemotherapy (HIPEC).possibly has a positive effect and is currently being tested. OBJECTIVES: This manuscript highlights the key role of CRS and HIPEC in patients with peritoneal metastases of gastric cancer and illustrates which patients benefit from this intensive therapy...
April 3, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29599360/transient-exocrine-pancreatic-insufficiency-first-report-of-an-unrecognized-complication-of-cytoreductive-surgery-and-hipec
#12
Samer A Naffouje, George I Salti
BACKGROUND: As cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are being increasingly adopted as the standard treatment for peritoneal surface malignancies, familiarity with this procedure's adverse events is also growing. Herein, we describe an unreported adverse event of exocrine pancreatic insufficiency (EPI) following CRS and HIPEC. PATIENTS AND METHODS: Patients who underwent CRS and HIPEC between 9/2016 and 9/2017 were prospectively recruited...
April 2018: Anticancer Research
https://www.readbyqxmd.com/read/29596098/a-dedicated-acute-pain-service-is-associated-with-reduced-postoperative-opioid-requirements-in-patients-undergoing-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy
#13
Engy T Said, Jacklynn F Sztain, Wendy B Abramson, Minhthy N Meineke, Timothy J Furnish, Ulrich H Schmidt, Gerard R Manecke, Rodney A Gabriel
BACKGROUND: The Acute Pain Service (APS) was initially introduced to optimize multimodal postoperative pain control. The aim of this study was to evaluate the association between the implementation of an APS and postoperative pain management and outcomes for patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS-HIPEC). METHODS: In this propensity-matched retrospective cohort study, we performed a before-after study without a concurrent control group...
March 27, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29589675/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-risk-factors-for-morbidity-and-postoperative-outcome
#14
Manuela Robella, Marco Vaira, Armando Cinquegrana, Alice Borsano, Michele DE Simone
BACKGROUND: Cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) represents a treatment option for peritoneal surface malignancies. Even if it has been reported that this new approach improved survival of selected patients, it's still associated with high morbidity and mortality rates. METHODS: From October 1995 to December 2017, over 450 patients patients affected by peritoneal carcinomatosis (PC) underwent in our Institute to CRS associated with HIPEC...
March 28, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29589077/-surgical-treatment-of-peritoneal-metastases-of-colorectal-cancer
#15
REVIEW
S Schüle, H Mothes, U Settmacher, J Zanow
Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) may significantly improve overall survival in selected patients with peritoneal metastases of colorectal cancer. For good oncological results complete macroscopic cytoreduction is crucial; furthermore, a linear correlation between peritoneal tumor load, as determined by the peritoneal cancer index (PCI) and overall survival has been demonstrated; therefore, surgical treatment should be initiated as early as possible. Synchronous resection of up to three liver metastases may be performed safely and with good results and no influence on the morbidity...
March 27, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29587771/treatment-of-intraoperatively-detected-peritoneal-carcinomatosis-of-colorectal-origin-with-cytoreductive-surgery-and-intraperitoneal-chemotherapy
#16
Aras Emre Canda, Cigdem Arslan, Cem Terzi, Selman Sokmen, Tugba Yavuzsen, Sevda Ozkardesler, Mehtat Unlu, Funda Obuz, Mehmet Fuzun
BACKGROUND: Diagnosis of peritoneal carcinomatosis (PC) may be missed by preoperative imaging. We are presenting our experience with incidentally detected PC of colorectal origin treated with cytoreductive surgery (CRS) and intraperitoneal chemotherapy (IPC) at the same operation. METHODS: Between January 2010 and September 2016, 19 patients underwent CRS and IPC due to incidentally detected PC of colorectal origin. Data were analyzed from a prospectively collected database...
March 27, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29573786/what-the-radiologist-should-know-about-postoperative-mdct-evaluation-of-a-patient-treated-with-cytoreductive-surgery-with-or-without-hyperthermic-intraperitoneal-chemotherapy
#17
REVIEW
C Durot, P Rousset, A Thivolet, G Passot, S Deguelte, A Dohan, O Glehen, C Hoeffel
Cytoreductive surgery (CRS), often associated with hyperthermic intraperitoneal chemotherapy (HIPEC), is now a well-recognised treatment for most peritoneal malignancies in selected patients. As imaging is frequently performed postoperatively, radiologists are increasingly confronted with postoperative multidetector-row computed tomography (MDCT) examinations in these cases. In this article, after briefly describing the procedures that are currently being performed for the treatment of peritoneal metastases, the normal postoperative MDCT changes that may be encountered after these procedures are described...
March 21, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29568842/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-gastrointestinal-cancers-fad-or-standard-of-care
#18
Melissa Ching Ching Teo, Grace Hwei Ching Tan
Peritoneal metastases (PM) are the common endpoint for patients with advanced gastrointestinal cancers. PM from these cancers are often managed in a similar fashion to other sites of systemic metastases, but the following must be taken into consideration. (a) PM do not respond to systemic chemotherapy in the same fashion as liver and lung metastases. (b) PM cause local problems, resulting in disruption of chemotherapy. (c) Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) actually work for PM...
March 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29565228/impact-of-tigecycline-versus-imipenem-cilastatin-on-fibrinogen-levels-following-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec-a-randomized-controlled-study
#19
Hakeam A Hakeam, Zainab Al Duhailib, Nawal Salahuddin, Tarek Amin
The aim of this prospective, randomized study was to compare the effects of tigecycline and imipenem-cilastatin on fibrinogen levels in patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). Patients were empirically randomized to receive tigecycline or imipenem-cilastatin. Fibrinogen levels were measured in both patient groups on days 1, 3, 5 and 8 of antibiotic therapy and 3 days after antibiotic therapy completion. Twenty patients received tigecycline and 22 patients received imipenem-cilastatin ...
March 22, 2018: Journal of Chemotherapy
https://www.readbyqxmd.com/read/29533028/effect-of-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-on-relapse-pattern-in-primary-epithelial-ovarian-cancer-a-propensity-score-based-case-control-study
#20
Marco Ceresoli, Apollonia Verrengia, Giulia Montori, Luisa Busci, Federico Coccolini, Luca Ansaloni, Luigi Frigerio
OBJECTIVE: Hyperthermic intraperitoneal chemotherapy (HIPEC) has been proposed as a treatment in ovarian cancer. A recently published RCT demonstrated that HIPEC prolongs disease-free survival (DFS) and overall survival (OS) in ovarian cancer. The aim of the study was to investigate oncologic results of cytoreductive surgery+HIPEC compared with cytoreductive surgery alone in advanced primary ovarian cancer with a particular attention to the pattern of recurrence. METHODS: This is a retrospective case control study with a propensity score (PS) matching of the patients...
March 12, 2018: Journal of Gynecologic Oncology
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