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hyperthermic intraperitoneal chemotherapy

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https://www.readbyqxmd.com/read/29019118/frailty-correlates-with-postoperative-mortality-and-major-morbidity-after-cytoreductive-surgery-with-hyperthermic-intraperitoneal-chemotherapy
#1
Ioannis T Konstantinidis, Konstantinos Chouliaras, Edward A Levine, Byrne Lee, Konstantinos I Votanopoulos
BACKGROUND: Frailty is increasingly being recognized as a powerful predictor of postoperative outcomes for cancer patients. This study examined the role of the modified frailty index (MFI) in predicting outcomes for patients undergoing cytoreduction (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: Data from National Surgical Quality Improvement Program (NSQIP) patients who underwent CRS/HIPEC between 2005 and 2014 were reviewed. The MFI, validated for use in NSQIP, was used to determine correlation between frailty and postoperative outcomes...
October 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29019106/antimicrobial-properties-of-perfusate-fluid-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-cs-hipec-with-mitomycin-c
#2
Krystle N Lange, Danielle McKay, Brian G Gentry, Jan Franko
BACKGROUND: Infectious postoperative complications often delay systemic chemotherapy after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CS-HIPEC). Because the authors have empirically observed fewer incisional infectious complications than expected after CS-HIPEC with mitomycin C (MMC), they investigated the antimicrobial properties of HIPEC perfusate fluid. METHODS: This study prospectively measured in vitro bacterial growth inhibition by HIPEC perfusate (n = 18)...
October 10, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29017824/early-postoperative-intraperitoneal-chemotherapy-is-associated-with-survival-benefit-for-appendiceal-adenocarcinoma-with-peritoneal-dissemination
#3
Yeqian Huang, Nayef A Alzahrani, Winston Liauw, Hussein Soudy, Abdulaziz M Alzahrani, David L Morris
INTRODUCTION: The combined approach of cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC) has achieved encouraging outcomes for patients with PMCA with peritoneal dissemination. However, there is little evidence for the use of EPIC in addition to HIPEC in this group of patients. PATIENTS AND METHODS: This was a retrospective study of prospectively collected data of consecutive patients with PMCA who underwent CRS and perioperative intraperitoneal chemotherapy by one surgical team at St George Hospital in Sydney, Australia between Jan 1996 and Aug 2016...
September 28, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28991079/peritoneal-involvement-is-more-common-than-nodal-involvement-in-patients-with-high-grade-appendix-tumors-who-are-undergoing-prophylactic-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#4
Akash Mehta, Rohin Mittal, Kandiah Chandrakumaran, Norman Carr, Sanjeev Dayal, Faheez Mohamed, Brendan Moran, Tom Cecil
BACKGROUND: Right hemicolectomy is routinely recommended in patients with histologic findings of high-grade appendix tumors after appendicectomy. Undetected peritoneal disease may be encountered at surgery. In high-grade appendix tumors with disease detected radiologically, complete cytoreduction may not be possible and outcomes poor. For these reasons, we adopted a policy of prophylactic cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. OBJECTIVE: The purpose of this study was to quantify the rates of peritoneal and nodal metastatic disease in patients with high-grade appendix tumors without obvious metastatic disease and to report the long-term outcomes of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in these patients...
November 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28986751/total-mesenteric-peritonectomy-for-peritoneal-metastases-with-video
#5
Jean-Baptiste Cazauran, Antoinette Lasseur, Arnaud Pasquer, Pascal Rousset, Jeremy Guedj, Guillaume Passot, Olivier Glehen
BACKGROUND: Complete cytoreductive surgery (CRS), combining organ resection and peritonectomy, is the only potentially curative treatment for patients with peritoneal metastases (PM).1 (,) 2 Diffuse mesenteric PM usually represents a contraindication for CRS.3 This report presents a standardized total mesenteric peritonectomy, which provides a therapeutic option of complete CRS for patients with diffuse mesenteric PM. PATIENT: A 73-year-old man had a diagnosis of PM caused by an urachal adenocarcinoma (signet cell type)...
October 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28982894/recurrence-and-survival-outcomes-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-small-bowel-adenocarcinoma
#6
Akshat Saxena, Sarah J Valle, Winston Liauw, David L Morris
BACKGROUND: Peritoneal dissemination of small bowel adenocarcinoma (SBA) is rare but is associated with a dismal prognosis. Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is a promising treatment option. We evaluated our experience of CRS-HIPEC for the treatment of SBA. PATIENTS AND METHODS: Sixteen consecutive patients underwent CRS-HIPEC for small bowel malignancy between 2003 and 2016. Clinopathological and treatment-related factors were obtained from a prospective database...
October 2017: Anticancer Research
https://www.readbyqxmd.com/read/28979717/stratification-of-outcomes-for-mucinous-appendiceal-adenocarcinoma-with-peritoneal-metastasis-by-histological-grade
#7
Travis Edward Grotz, Richard E Royal, Paul F Mansfield, Michael James Overman, Gary N Mann, Kristen Ashlee Robinson, Karen A Beaty, Safiea Rafeeq, Auerlio Matamoros, Michelle W Taggart, Keith Francis Fournier
AIM: To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma (MAA). METHODS: Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated...
September 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28978237/exploring-the-trend-in-referrals-for-consideration-of-crs-and-hipec-to-understand-the-attitudes-of-clinicians-in-the-development-of-a-national-cancer-centre-program-in-peritoneal-disease
#8
Weining Wang, Grace Hwei Ching Tan, Thakshayeni Skanthakumar, Claramae Shulyn Chia, Khee Chee Soo, Melissa Ching Ching Teo
INTRODUCTION: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) improve survival in selected patients with peritoneal metastases. However, only some patients who are potentially eligible for the procedure are considered and referred to the appropriate surgical department. By studying the trends of patients being considered for CRS and HIPEC in our center, we hope to better understand the demographics of our patient cohort and the attitudes of physicians involved towards CRS and HIPEC...
October 4, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28967566/multi-institutional-study-of-peritoneal-sarcomatosis-from-uterine-sarcoma-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#9
Armando Sardi, Arkadii Sipok, Dario Baratti, Marcello Deraco, Paul Sugarbaker, George Salti, Yutaka Yonemura, Paolo Sammartino, Olivier Glehen, Naoual Bakrin, Teresa P Díaz-Montes, Vadim Gushchin
OBJECTIVE: Uterine sarcoma (US) is a rare tumor representing 1% of female genital tract malignancies. Peritoneal sarcomatosis (PS) after US, diminishes median overall survival (OS) and progression-free survival (PFS) with cytoreductive surgery (CRS) alone, with or without systemic chemotherapy is <1 year and 6 months, respectively. A multi-institutional review of PS from US was conducted to evaluate CRS and hyperthermic intraperitoneal chemotherapy (HIPEC) and effects on survival outcomes...
September 7, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28940461/incidence-and-predictors-of-postoperative-delirium-after-cytoreduction-surgery-hyperthermic-intraperitoneal-chemotherapy
#10
Matthijs Plas, Patrick H J Hemmer, Lukas B Been, Robert J van Ginkel, Geertruida H de Bock, Barbara L van Leeuwen
BACKGROUND: Incidence of, and baseline characteristics associated with delirium in patients after cytoreduction surgery-hyperthermic intraperitoneal chemotherapy (CRS-HIPEC), were subject of investigation. METHODS: The study was conducted among a consecutive series of prospectively included patients who underwent CRS-HIPEC at the University Medical Center Groningen, Groningen, the Netherlands, between February 2006 and January 2015. A chart-based instrument for delirium during hospitalization was used to identify patients with symptoms of delirium who were not diagnosed by a psychiatrist during admission...
September 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28936563/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-colorectal-peritoneal-metastases-from-novelty-to-routine-in-selected-cases
#11
REVIEW
B J Moran
No abstract text is available yet for this article.
September 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28929277/fluorescence-guided-surgery-in-the-combined-treatment-of-peritoneal-carcinomatosis-from-colorectal-cancer-preliminary-results-and-considerations
#12
Eva Lieto, Annamaria Auricchio, Francesca Cardella, Andrea Mabilia, Nicoletta Basile, Paolo Castellano, Michele Orditura, Gennaro Galizia
BACKGROUND: Indocyanine green (ICG) is a near-infrared fluorescent contrast agent, which preferentially accumulates in cancer tissue. The aim of our study was to investigate the role of fluorescence imaging (FI) with ICG (ICG-FI) for detecting peritoneal carcinomatosis (PC) from colorectal cancer (CRC). METHODS: Four CRC patients with PC scheduled for cytoreductive surgery + hyperthermic intraperitoneal chemotherapy were enrolled in this prospective study. At a median time of 50 min after 0...
September 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28903452/cytoreductive-surgery-plus-hyperthermic-intraperitoneal-chemotherapy-improves-survival-for-peritoneal-carcinomatosis-from-colorectal-cancer-a-systematic-review-and-meta-analysis-of-current-evidence
#13
REVIEW
Chao-Qun Huang, Yao Min, Shu-Yi Wang, Xiao-Jun Yang, Yang Liu, Bin Xiong, Yutaka Yonemura, Yan Li
OBJECTIVES: The therapeutic efficacy of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) for patients with peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is still under debate. This meta-analysis and systematic review of published literature on this comprehensive strategy aims to evaluate its efficacy on CRC patients with PC. METHODS: A systemic review with meta-analysis of published literatures on treatment of CRS plus HIPEC for patients with PC from CRC was performed...
August 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28895112/external-validation-of-the-prognostic-nomogram-compass-for-patients-with-peritoneal-carcinomatosis-of-colorectal-cancer
#14
Karel Demey, Albert Wolthuis, Anthony de Buck van Overstraeten, Steffen Fieuws, Vincent Vandecaveye, Eric Van Cutsem, André D'Hoore
BACKGROUND: To optimize outcome, selection of patients for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) is critical. Recently, Simkens et al.7 evaluated the peritoneal surface disease severity score (PSDSS) and suggested a new prognostic nomogram, the colorectal peritoneal metastases prognostic surgical score (COMPASS) based on age, peritoneal carcinomatosis index score, locoregional lymph node status, and signet ring cell histology. This COMPASS nomogram had better discriminative ability according to the Harrell c-index than PSDSS (c = 0...
September 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28893108/comparative-efficacy-evaluation-of-catheter-intraperitoneal-chemotherapy-normothermic-and-hyperthermic-chemoperfusion-in-a-rat-model-of-ascitic-ovarian-cancer
#15
V G Bespalov, I K Alvovsky, G V Tochilnikov, A N Stukov, E A Vyshinskaya, A L Semenov, I N Vasilyeva, O A Belyaeva, G S Kireeva, K Y Senchik, J D Von, L A Krasilnikova, V A Alexandrov, N N Khromov-Borisov, D A Baranenko, A M Belyaev
OBJECTIVES: The choice of an optimal administration route for intraperitoneal (IP) chemotherapy and a suitable chemotherapeutic regime in the treatment of ovarian cancer remains a controversy. We investigated survival outcomes according to catheter intraperitoneal chemotherapy (CIPC), normothermic and hyperthermic chemoperfusion (NIPEC and HIPEC) with cytostatic drugs dioxadet and cisplatin in rats with transplantable ascitic ovarian cancer. METHODS: Ascitic liquid containing 1·10(7) tumor cells was inoculated to female Wistar rats and 48 hours after rats received dioxadet and cisplatin at the maximum tolerated doses...
September 11, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28890830/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-combined-with-two-stage-hepatectomy-for-multiple-and-bilobar-desmoplastic-small-round-cell-tumor-liver-metastases
#16
Alejandro Cracco, Mayank Roy, Conrad H Simpfendorfer
Desmoplastic small round cell tumor (DSRCT) is a rare mesenchymal tumor usually affecting young patients. Local dissemination is common, and liver is the most common site for extraperitoneal metastases. Multimodal management has been shown to be the most effective treatment. Some authors consider liver metastases especially bi-lobar disease as a contraindication for surgical resection. We present a case of a DSRCT with bi-lobar metastases in an adult patient who underwent multi-modal management along with hepatectomy...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890825/splenectomy-is-an-independent-risk-factor-for-poorer-perioperative-outcomes-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-an-analysis-of-936-procedures
#17
Akshat Saxena, Winston Liauw, David L Morris
BACKGROUND: There is a paucity of data on the impact of splenectomy on peri-operative outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). We report the largest series to date which addresses this topic. METHODS: Nine hundred and thirty six consecutive patients underwent CRS/HIPEC from 1996 to 2016 at a high-volume institution in Sydney, Australia. Of these, 418 (45%) underwent splenectomy. Peri-operative complications were graded according to the Clavien-Dindo Classification...
August 2017: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28890671/current-management-of-peritoneal-carcinomatosis-from-colorectal-cancer-the-role-of-cytoreductive-surgery-and-hyperthermic-peritoneal-chemoperfusion
#18
Ibrahim Nassour, Patricio M Polanco
Peritoneal carcinomatosis (PC) from colorectal cancer (CRC) is a disease with a poor prognosis, often thought to be a terminal illness with no hope except for palliative treatment. New therapeutic modalities combining cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have shown favorable outcomes and may provide a significant survival benefit in a selected group of patients. The main rational for CRS is to remove all visible tumor burden to allow for the chemotherapeutic agent (HIPEC) to eradicate any microscopic residual disease...
April 2017: Current Colorectal Cancer Reports
https://www.readbyqxmd.com/read/28881641/colorectal-cancer-at-high-risk-of-peritoneal-metastases-long-term-outcomes-of-a-pilot-study-on-adjuvant-laparoscopic-hipec-and-future-perspectives
#19
Charlotte E L Klaver, Roos Stam, Didi A M Sloothaak, Johannes Crezee, Willem A Bemelman, Cornelis J A Punt, Pieter J Tanis
OBJECTIVE: Early detection of peritoneal metastases (PM) of colorectal cancer (CRC) is difficult and treatment options at a clinically overt stage are limited. Potentially, adjuvant laparoscopic hyperthermic intraperitoneal chemotherapy (HIPEC) is of value. The aim of this study was to present long term oncological outcomes of a pilot study on adjuvant HIPEC to reduce development of PMCRC, with systematic review of literature. METHODS: Long term oncological outcomes of ten patients who underwent laparoscopic HIPEC within eight weeks after resection of primary CRC in the pilot study were retrospectively collected...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28877609/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-the-treatment-of-advanced-epithelial-and-recurrent-ovarian-carcinoma-a-single-center-experience
#20
Maja J Pavlov, Miljan S Ceranic, Stojan M Latincic, Predrag V Sabljak, Dragutin M Kecmanovic, Paul H Sugarbaker
BACKGROUND: With standard treatment of epithelial ovarian cancer (EOC), prognosis is very poor. The aim of this study is to show early and late results in patients who underwent cytoreductive surgery and intraperitoneal chemotherapy. PATIENTS AND METHODS: This was a retrospective single centre study. All patients with advanced and recurrent ovarian cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) or modified early postoperative intraperitoneal chemotherapy (EPIC) were included in the study...
September 7, 2017: International Journal of Hyperthermia
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