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hypothyroidism associated bladder dysfunction

Sahzene Yavuz, Andrea B Apolo, Shivaani Kummar, Jaydira del Rivero, Ravi A Madan, Thomas Shawker, James Reynolds, Francesco S Celi
BACKGROUND: Thyroid dysfunction is a common adverse event associated with tyrosine kinase inhibitors (TKI), but its underlying pathophysiology is unclear. Cabozantinib is a novel TKI currently Food and Drug Administration approved for advanced medullary thyroid cancer and tested in clinical trials on solid tumors including prostate, liver, bladder, breast, and ovarian cancer. METHODS: We analyzed the thyroid function of patients enrolled in two phase 2 clinical trials using cabozantinib at the National Institutes of Health Clinical Center...
August 2014: Thyroid: Official Journal of the American Thyroid Association
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