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https://www.readbyqxmd.com/read/27916652/exploring-pericyte-and-cardiac-stem-cell-secretome-unveils-new-tactics-for-drug-discovery
#1
REVIEW
Georgina M Ellison-Hughes, Paolo Madeddu
Ischaemic diseases remain a major cause of morbidity and mortality despite continuous advancements in medical and interventional treatments. Moreover, available drugs reduce symptoms associated with tissue ischaemia, without providing a definitive repair. Cardiovascular regenerative medicine is an expanding field of research that aims to improve the treatment of ischaemic disorders through restorative methods, such as gene therapy, stem cell therapy, and tissue engineering. Stem cell transplantation has salutary effects through direct and indirect actions, the latter being attributable to growth factors and cytokines released by stem cells and influencing the endogenous mechanisms of repair...
December 1, 2016: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/27914387/investigation-of-horizontal-refraction-on-florida-straits-continental-shelf-using-a-three-dimensional-gaussian-ray-bundling-model
#2
Sean M Reilly, Gopu R Potty, David Thibaudeau
Acoustic transmission loss measurements from the calibration operations (CALOPS) experiment for the Shallow Water Array Performance (SWAP) program included horizontally refracted returns that were as much as 30° away from the true bearing between source and receiver. In many cases, the in-shore refracted path was 20 dB stronger than the true bearing path. In this study CALOPS transmission loss measurements at 415 Hz are compared to predictions from a three-dimensional Gaussian ray bundling model. The geoacoustic model that provides good model-data comparison is consistent with the geologic and sediment core data collected at the location but differs slightly from the bottom model used at lower frequencies (206 and 52...
September 2016: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/27910363/a-small-long-life-acoustic-transmitter-for-studying-the-behavior-of-aquatic-animals
#3
J Lu, Z D Deng, H Li, M J Myjak, J J Martinez, J Xiao, R S Brown, S S Cartmell
Acoustic telemetry is an important tool for studying the behavior of aquatic animals and assessing the environmental impact of structures such as hydropower facilities. However, the physical size, signal intensity, and service life of off-the-shelf transmitters are presently insufficient for monitoring certain species. In this study, we developed a small, long-life acoustic transmitter with an approximate length of 24.2 mm, diameter of 5.0 mm, and dry weight of 0.72 g. The transmitter generates a coded acoustic signal at 416...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27907008/an-assemblable-multi-angle-fluorescence-and-ellipsometric-microscope
#4
Victoria Nguyen, John Rizzo, Babak Sanii
We introduce a multi-functional microscope for research laboratories that have significant cost and space limitations. The microscope pivots around the sample, operating in upright, inverted, side-on and oblique geometries. At these geometries it is able to perform bright-field, fluorescence and qualitative ellipsometric imaging. It is the first single instrument in the literature to be able to perform all of these functionalities. The system can be assembled by two undergraduate students from a provided manual in less than a day, from off-the-shelf and 3D printed components, which together cost approximately $16k at 2016 market prices...
2016: PloS One
https://www.readbyqxmd.com/read/27903485/endovascular-repair-of-thoraco-abdominal-aortic-aneurysm-in-high-surgical-risk-patients-fenestrated-and-branched-endografts
#5
E Gallitto, M Gargiulo, A Freyrie, C Bianchini Massoni, R Pini, C Mascoli, G L Faggioli, S Ancetti, A Stella
AIM: To report early and mid-term results of endovascular repair of thoraco-abdominal aneurysms (TAAA) by using of Cook-Zenith fenestrated/branched endografts (FB-EVAR) in high-surgical risk patients unfit for open repair (OR). METHODS: Between January 2012 and April 2015, all the patients with TAAA, considered at high-surgical risk for OR and treated by Cook-Zenith FB-EVAR, were prospectively enrolled. Patients were studied using a thoraco-abdominal computer tomography angiography (CTA) and dedicated software for advanced vessels analysis...
November 26, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27889203/changes-in-renal-anatomy-after-fenestrated-endovascular-aneurysm-repair
#6
B Maurel, Y Lounes, M Amako, D Fabre, A Hertault, J Sobocinski, R Spear, R Azzaoui, T M Mastracci, S Haulon
OBJECTIVE: To assess short- and long-term movement of renal arteries after fenestrated endovascular aortic repair (FEVAR). METHODS: Consecutive patients who underwent FEVAR at one institution with a custom-made device designed with fenestrations for the superior mesenteric (SMA) and renal arteries, a millimetric computed tomography angiography (CTA), and a minimum of 2 years' follow-up were included. Angulation between renal artery trunk and aorta, clock position of the origin of the renal arteries, distance between renal arteries and SMA, and target vessel occlusion were retrospectively collected and compared between the pre-operative, post-operative (<6 months), and last (>12 months) CTA...
November 24, 2016: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/27887822/decline-of-trace-metal-pollution-in-the-bottom-sediments-of-the-barcelona-city-continental-shelf-nw-mediterranean
#7
Albert Palanques, Laura Lopez, Jorge Guillén, Pere Puig, Pere Masqué
The evolution of trace metal pollution on the Barcelona city continental shelf during the last few decades was studied by analyzing the historical records of trace metals in sediment cores and surface sediment samples taken at the same locations in 1987 and in 2008. Polluted surface samples taken in 1987 reached enrichment factors of up to 490 for Hg, about 40 for Pb and Cd, and about 17 for Zn, Cr and Cu. The data show a decline of up to one order of magnitude in the trace metal content of surface sediments during the last few decades, with maximum enrichment factors of between 20 and 30 for Hg and Cd and between 5 and 12 for Zn, Cr, Pb and Cu...
November 22, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27872015/self-hardening-and-thermoresponsive-alpha-tricalcium-phosphate-pluronic-pastes
#8
Yassine Maazouz, Edgar B Montufar, Julien Malbert, Montserrat Espanol, Maria-Pau Ginebra
: Although calcium phosphate cements (CPCs) are used for bone regeneration in a wide range of clinical applications, various physicochemical phenomena are known to hinder their potential use in minimally invasive surgery or in highly vascularized surgical sites, mainly because of their lack of injectability or their low washout resistance. The present work shows that the combination of CPCs with an inverse-thermoresponsive hydrogel is a good strategy for finely tuning the cohesive and rheological properties of CPCs to achieve clinical acceptable injectability to prevent phase separation during implantation and cohesion to avoid washout of the paste...
November 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27862606/abiotic-proxies-for-predictive-mapping-of-near-shore-benthic-assemblages-implications-for-marine-spatial-planning
#9
Jennifer McHenry, Robert S Steneck, Damian C Brady
Marine spatial planning (MSP) should assist managers in guiding human activities towards sustainable practices and in minimizing user-conflicts in our oceans. A necessary first step is to quantify spatial patterns of marine assemblages in order to understand the ecosystem's structure, function, and services. However, the large spatial scale, high economic value, and density of human activities in near-shore habitats often makes quantifying this component of marine ecosystems especially daunting. To address this challenge, we developed an assessment method that employs abiotic proxies to rapidly characterize marine assemblages in near-shore benthic environments with relatively high resolution...
November 16, 2016: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/27828125/easy-to-operate-calibration-method-for-structured-light-systems
#10
Rui Chen, Jing Xu, Zhiling Ye, Jiadi Li, Yong Guan, Ken Chen
Traditional calibration methods of structured light measurement systems are expensive and difficult to operate. In this paper, an accurate, low-cost, and easy-to-operate calibration method is proposed, where each projector pixel is considered as a line-of-sight in space, and an off-the-shelf LCD monitor is used to display the calibration pattern. Experimental results verify the accuracy and validity of the proposed method.
October 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27801968/estuary-ocean-connectivity-fast-physics-slow-biology
#11
Mélanie Raimonet, James E Cloern
Estuaries are connected to both land and ocean so their physical, chemical and biological dynamics are influenced by climate patterns over watersheds and ocean basins. We explored climate-driven oceanic variability as a source of estuarine variability by comparing monthly time series of temperature and chlorophyll-a inside San Francisco Bay with those in adjacent shelf waters of the California Current System (CCS) that are strongly responsive to wind-driven upwelling. Monthly temperature fluctuations inside and outside the Bay were synchronous, but their correlations weakened with distance from the ocean...
November 1, 2016: Global Change Biology
https://www.readbyqxmd.com/read/27796832/developing-monitoring-plans-to-detect-spills-related-to-natural-gas-production
#12
Aubrey E Harris, Leslie Hopkinson, Daniel J Soeder
Surface water is at risk from Marcellus Shale operations because of chemical storage on drill pads during hydraulic fracturing operations, and the return of water high in total dissolved solids (up to 345 g/L) from shale gas production. This research evaluated how two commercial, off-the-shelf water quality sensors responded to simulated surface water pollution events associated with Marcellus Shale development. First, peak concentrations of contaminants from typical spill events in monitored watersheds were estimated using regression techniques...
December 0: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27792474/comparison-of-coarse-coal-dust-sampling-techniques-in-a-laboratory-simulated-longwall-section
#13
Justin R Patts, Teresa L Barone
Airborne coal dust generated during mining can deposit and accumulate on mine surfaces, presenting a dust explosion hazard. When assessing dust hazard mitigation strategies for airborne dust reduction, sampling is done in high-velocity ventilation air, which is used to purge the mining face and gallery tunnel. In this environment, the sampler inlet velocity should be matched to the air stream velocity (isokinetic sampling) to prevent oversampling of coarse dust at low sampler-to-air velocity ratios. Low velocity ratios are often encountered when using low flow rate, personal sampling pumps approved for use in underground mines...
October 28, 2016: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/27774614/blood-component-transfusion-and-wastage-rates-in-the-setting-of-massive-transfusion-in-three-regional-trauma-centers
#14
Nancy M Dunbar, Nicholas J Olson, Zbigniew M Szczepiorkowski, Eric D Martin, Ryan M Tysarcyk, Darrell J Triulzi, Louis H Alarcon, Mark H Yazer
BACKGROUND: The purpose of massive transfusion protocols (MTPs) is to provide large quantities of blood products rapidly to exsanguinating patients. The expected rates of blood product transfusion and wastage in this setting have not been defined. This study was undertaken to assess the transfusion and wastage rates for bleeding patients requiring emergency issue of blood components at three American Level I trauma centers. STUDY DESIGN AND METHODS: Three hospitals participated, all of which are Level I trauma centers that have MTPs in place where uncrossmatched red blood cells (RBCs) can be ordered with or without platelets (PLTs), plasma, and cryoprecipitate...
October 23, 2016: Transfusion
https://www.readbyqxmd.com/read/27770988/dolphins-in-a-scaled-down-mediterranean-the-gulf-of-corinth-s-odontocetes
#15
G Bearzi, S Bonizzoni, N L Santostasi, N B Furey, L Eddy, V D Valavanis, O Gimenez
The Gulf of Corinth is a 2400-km(2) semi-enclosed inland system (a mediterraneus) in central Greece. Its continental shelf areas, steep bottom relief, and waters up to 500-900m deep offer suitable habitat to neritic and pelagic species. We used photographic capture-recapture, distribution modelling, and direct observations to investigate the abundance, status, habitat preferences, movements, and group size of four odontocete species regularly observed in the Gulf, based on five years (2011-2015) of survey effort from small boats...
2016: Advances in Marine Biology
https://www.readbyqxmd.com/read/27768661/direct-site-endovascular-repair-dser-a-novel-approach-to-vascular-trauma
#16
Anders J Davidson, Lucas P Neff, Joseph J DuBose, James B Sampson, Christopher M Abbot, Timothy K Williams
Peripheral vascular injuries carry significant risk for permanent functional impairment, limb loss, and death. Definitive correction of these injuries requires significant operative time and has traditionally been resource and skill set intensive. In the initial surgical treatment of the physiologically depleted trauma patient, faster techniques may prove more appropriate. Damage control techniques, including vascular shunting, rapidly restore distal flow but require additional vascular intervention and risk shunt thrombosis with prolonged use...
November 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/27718105/bruises-in-beef-cattle-at-slaughter-in-mexico-implications-on-quality-safety-and-shelf-life-of-the-meat
#17
Rosy G Cruz-Monterrosa, Verónica Reséndiz-Cruz, Armando A Rayas-Amor, Marcos López, Genaro C Miranda-de la Lama
In emergent economies and developing countries of Africa, Asia and Latin America, the major cause for carcass rejection from the international market is bruising; nevertheless, many of these carcases are destined to local markets and meat processing industries for human consumption. Therefore, the aim of the present study was to assess the effect of bruised meat on pH, microbiologic count and biogenic amine (BA) profiles along 21 days of ageing (sampling 1st, 7th, 14th and 21st day) with two packaging method (plastic bag vs vacuum) at 4 °C...
October 7, 2016: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/27711542/bottom-up-excited-state-dynamics-of-two-cinnamate-based-sunscreen-filter-molecules
#18
Yoann Peperstraete, Michael Staniforth, Lewis A Baker, Natércia D N Rodrigues, Neil C Cole-Filipiak, Wen-Dong Quan, Vasilios G Stavros
Methyl-E-4-methoxycinnamate (E-MMC) is a model chromophore of the commonly used commercial sunscreen agent, 2-ethylhexyl-E-4-methoxycinnamate (E-EHMC). In an effort to garner a molecular-level understanding of the photoprotection mechanisms in operation with E-EHMC, we have used time-resolved pump-probe spectroscopy to explore E-MMC's and E-EHMC's excited state dynamics upon UV-B photoexcitation to the S1 (1(1)ππ*) state in both the gas- and solution-phase. In the gas-phase, our studies suggest that the excited state dynamics are driven by non-radiative decay from the 1(1)ππ* to the S3 (1(1)nπ*) state, followed by de-excitation from the 1(1)nπ* to the ground electronic state (S0)...
October 12, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27706813/optimization-of-vacuum-impregnation-with-calcium-lactate-of-minimally-processed-melon-and-shelf-life-study-in-real-storage-conditions
#19
Silvia Tappi, Urszula Tylewicz, Santina Romani, Lorenzo Siroli, Francesca Patrignani, Marco Dalla Rosa, Pietro Rocculi
Vacuum impregnation (VI) is a processing operation that permits the impregnation of fruit and vegetable porous tissues with a fast and more homogeneous penetration of active compounds compared to the classical diffusion processes. The objective of this research was to investigate the impact on VI treatment with the addition of calcium lactate on qualitative parameters of minimally processed melon during storage. For this aim, this work was divided in 2 parts. Initially, the optimization of process parameters was carried out in order to choose the optimal VI conditions for improving texture characteristics of minimally processed melon that were then used to impregnate melons for a shelf-life study in real storage conditions...
October 5, 2016: Journal of Food Science
https://www.readbyqxmd.com/read/27687323/midterm-results-from-a-physician-sponsored-investigational-device-exemption-clinical-trial-evaluating-physician-modified-endovascular-grafts-for-the-treatment-of-juxtarenal-aortic-aneurysms
#20
Benjamin W Starnes, Rachel E Heneghan, Billi Tatum
OBJECTIVE: The objective of this study was to report midterm results of an ongoing physician-sponsored investigational device exemption pivotal clinical trial using physician-modified endovascular grafts (PMEGs) for treatment of patients with juxtarenal aortic aneurysms who are deemed unfit for open repair. METHODS: Data from a nonrandomized, prospective, consecutively enrolling investigational device exemption clinical trial were used. Data collection began on April 1, 2011, and data lock occurred on May 31, 2015, with outcomes analysis through December 31, 2015...
September 26, 2016: Journal of Vascular Surgery
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