Read by QxMD icon Read

Shelf operation

Carla Dessels, Marco Alessandrini, Michael Sean Pepper
Hematopoietic stem cell transplantation (HSCT) is common practice today for life threatening malignant and non-malignant diseases of the blood and immune systems. Umbilical cord blood (UCB) is rich in hematopoietic stem cells (HSCs) and is an attractive alternative to harvesting HSCs from bone marrow or when mobilized into peripheral blood. One of the most appealing attributes of UCB is that it can be banked for future use and hence provides an off-the-shelf solution for patients in urgent need of a transplantation...
May 18, 2018: Stem Cells Translational Medicine
Long Wang, Yong Liu, Zengshan Yin
To achieve launch-on-demand for Operationally Responsive Space (ORS) missions, in this article, an intra-satellite wireless network (ISWN) is presented. It provides a wireless and modularized scheme for intra-spacecraft sensing and data buses. By removing the wired data bus, the commercial off-the-shelf (COTS) based wireless modular architecture will reduce both the volume and weight of the satellite platform, thus achieving rapid design and cost savings in development and launching. Based on the on-orbit data demand analysis, a hybrid time division multiple access/carrier sense multiple access (TDMA/CSMA) protocol is proposed...
May 12, 2018: Sensors
Martin Wagner, Panos Skandamis, Franz Allerberger, Dagmar Schoder, Caroline Lassnig, Mathias Müller, Kathrin Rychli
A cluster of 34 human cases of listeriosis was traced to consumption of contaminated quargel cheese, a sour milk specialty sold in Austria, Germany and Czech Republic. Here, we try to assess how many portions were consumed by the Austrian population at a certain contamination level (CL). In total, 1623 cheese lots were produced during the outbreak period resulting in >3 million portions of cheese delivered to the market. From 650 sets of quality control data provided by the food business operator, we reconstructed the contamination scenario over time and identified 84 lots that were found to be positive...
April 20, 2018: International Journal of Food Microbiology
Tong Zhu, Ehab M Moussa, Madeleine Witting, Deliang Zhou, Kushal Sinha, Mario Hirth, Martin Gastens, Sherwin Shang, Nandkishor Nere, Shubha Chetan Somashekar, Alina Alexeenko, Feroz Jameel
Scale-up and technology transfer of lyophilization processes remains a challenge that requires thorough characterization of the laboratory and larger scale lyophilizers. In this study, computational fluid dynamics (CFD) was employed to develop computer-based models of both laboratory and manufacturing scale lyophilizers in order to understand the differences in equipment performance arising from distinct designs. CFD coupled with steady state heat and mass transfer modeling of the vial were then utilized to study and predict independent variables such as shelf temperature and chamber pressure, and response variables such as product resistance, product temperature and primary drying time for a given formulation...
May 4, 2018: European Journal of Pharmaceutics and Biopharmaceutics
Marina Dias-Neto, José Fernando Ramos, João Rocha Neves, Pedro Almeida, Augusto Rocha E Silva, José Fernando Teixeira
Introduction The rupture of thoracoabdominal aneurysms (rTAA) represents one of the major challenges to the vascular surgeon. Recent developments in the endovascular armamentarium and the high mortality from open surgery make endovascular treatment an attractive option. Devices to be used in an emergency environment should be "off-the-shelf" and include, among others, EVAR snorkel/chimney and branched endoprosthesis (T-branch, Cook®). METHODS: We describe the case of a 70-year-old patient who was admitted to the emergency room due continuous low back pain with 3 days of evolution...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
Xiaoli Liu, Gang Zhao, Zhongrong Chen, Fazil Panhwar, Xiaoming He
Stem cells microencapsulated in hydrogel as stem cell-hydrogel constructs have wide applications in the burgeoning cell-based medicine. Due to their short shelf life at ambient temperature, long-term storage or banking of the constructs is essential to their "off-the-shelf" ready availability needed for their widespread applications. As a high-efficiency, easy-to-operate, low-toxic and low-cost method for long-term storage of the constructs, low-cryoprotectant (CPA) vitrification has attracted tremendous attention recently...
April 24, 2018: ACS Applied Materials & Interfaces
Nam-Hoon Kim, Van Sy Pham, Jin Hwan Hwang, Nam Il Won, Ho Kyung Ha, Jungho Im, Youngsung Kim
When mixtures of aggregates and water dredged from the seabed are discharged at the surface into the adjacent water from a barge, coarse sediments sink immediately and fine sediments are suspended forming a plume. Recently, elongated plumes of fine sediment were observed by satellites near a dredging location on the continental shelf. Such plume streaks were longer in certain conditions with seasonality than expected or reported previously. Therefore, the present work studied the appearance of sediment plume with field measurements and numerical simulations and explains the seasonally varying restoring force and thicknesses of the surface mixed layer resulting from the vertical density distribution near the surface, along with mixing by hydrodynamic process...
April 2018: Marine Pollution Bulletin
Mayela Mendt, Sushrut Kamerkar, Hikaru Sugimoto, Kathleen M McAndrews, Chia-Chin Wu, Mihai Gagea, Sujuan Yang, Elena V Rodriges Blanko, Qian Peng, Xiaoyan Ma, Joseph R Marszalek, Anirban Maitra, Cassian Yee, Katayoun Rezvani, Elizabeth Shpall, Valerie S LeBleu, Raghu Kalluri
Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded siRNA, to cancer cells. Here, we report on a bioreactor-based, large-scale production of clinical-grade exosomes employing good manufacturing practice (GMP) standards. A standard operating procedure was established to generate engineered exosomes with the ability to target oncogenic Kras (iExosomes). The clinical-grade GMP iExosomes were tested in multiple in vitro and in vivo studies to confirm suppression of oncogenic Kras and an increase in the survival of several mouse models with pancreatic cancer...
April 19, 2018: JCI Insight
Abraham Gila, Mohamed Aymen Bejaoui, Gabriel Beltrán, María Paz Aguilera, Antonio Jiménez
BACKGROUND: Vertical centrifugation is the main method for virgin olive oil (VOO) clarification. However, in the last years, settling tanks are being used to clarify the oil from decanter. They can operate under static or dynamic conditions. In this work, we compared the vertical centrifugation and settling under dynamic conditions for VOO clarification and their effect on VOO characteristics. RESULTS: VOO quality parameters were not affected by the clarification systems studied...
April 16, 2018: Journal of the Science of Food and Agriculture
Anne Guro Vreim Holm, Olav Reikerås, Terje Terjesen
Objective: To study the effects of the Spitzy shelf operation on hip pain. Method: A modified Spitzy shelf procedure was performed in 60 hips with residual hip dysplasia. The mean age at surgery was 11.7 years (range 5.5-22.4 years). Results: Twenty-one hips had pain preoperatively. One year postoperatively 57 hips (95%) were painless. The mean postoperative painless period in patients with >10 years follow-up was 24.1 years (range 5...
March 2018: Journal of Orthopaedics
Dries Vandeweyer, Enya Wynants, Sam Crauwels, Christel Verreth, Nikolaas Viaene, Johan Claes, Bart Lievens, Leen Van Campenhout
In this study, the microbiota during industrial rearing, processing, and storage of the edible tropical house cricket, Gryllodes sigillatus , was investigated. To this end, samples were analyzed of the cricket feed, before feeding as well as taken from the cages, and the crickets during rearing, after harvest, and after processing into frozen, oven-dried, and smoked and subsequently oven-dried end products. Although the feed contained lower microbial numbers than the crickets, both were dominated by the same species-level operational taxonomic units as determined by Illumina Miseq sequencing...
April 6, 2018: Applied and Environmental Microbiology
Roberto A Mendoza-Gallegos, Amelia Rios, Jose Luis Garcia-Cordero
The polymerase chain reaction (PCR) is a sought-after nucleic acid amplification technique used in the detection of several diseases. However, one of the main limitations of this and other nucleic acid amplification assays is the complexity, size, maintenance, and cost of their operational instrumentation. This limits the use of PCR applications in settings that cannot afford the instruments-yet may have access to basic electrical, electronic, and optical components and the expertise to build them. To provide a more accessible platform, we developed a low-cost, palm-size and portable instrument to perform real-time PCR (qPCR)...
April 6, 2018: Analytical Chemistry
Stanislava Voběrková, Veronika Solčány, Martina Vršanská, Vojtěch Adam
Ligninolytic enzymes from white-rot fungi are widely used in biotechnological processes. However, the application of these enzymes as free enzymes is limited due to their instability and lack of reusability. Enzyme stabilization is therefore a major challenge in biocatalytic process research, and immobilization methods are desirable. Using cross-linked enzyme aggregates (CLEAs) such as magnetic CLEAs, porous-CLEAs and combi-CLEAs is a promising technique for overcoming these issues. Cross-linking methods can stabilize and immobilize enzymes by interconnecting enzyme molecules via multiple bonds using cross-linking agents such as glutaraldehyde...
March 14, 2018: Chemosphere
Hidetatsu Tanaka, Daisuke Chiba, Yu Mori, Yoshiyuki Kuwahara, Kazuyoshi Baba, Norikazu Yamada, Genji Fujii, Eiji Itoi
The purpose of the current study was to retrospectively evaluate the long-term outcome of our shelf operation for acetabular dysplasia in adults and adolescents. We evaluated the outcome of shelf operation performed in 35 hips of 32 patients with acetabular dysplasia between 1978 and 1996. The mean age at the time of surgery was 30.6 years, and the mean follow-up period was 25.9 years. The pre-operative stage of osteoarthritis was Tönnis grade 0 in 12 hips and grade 1 in 23 hips. Clinical evaluation using the JOA hip score showed more than 85 of 100 points over 25 years...
March 29, 2018: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
Jeanne-Marie Membré, Géraldine Boué
The objective of this article is to bring scientific background as well as practical hints and tips to guide risk assessors and modelers who want to develop a quantitative Microbiological Risk Assessment (MRA) in an industrial context. MRA aims at determining the public health risk associated with biological hazards in a food. Its implementation in industry enables to compare the efficiency of different risk reduction measures, and more precisely different operational settings, by predicting their effect on the final model output...
April 2018: Food Research International
Qiang Lu, Guanghui Liu, Chuanli Xiao, Chuanzhen Hu, Shiwu Zhang, Ronald X Xu, Kaiqin Chu, Qianming Xu, Zachary J Smith
In this paper we report the development of a cost-effective, modular, open source, and fully automated slide-scanning microscope, composed entirely of easily available off-the-shelf parts, and capable of bright field and fluorescence modes. The automated X-Y stage is composed of two low-cost micrometer stages coupled to stepper motors operated in open-loop mode. The microscope is composed of a low-cost CMOS sensor and low-cost board lenses placed in a 4f configuration. The system has approximately 1 micron resolution, limited by the f/# of available board lenses...
2018: PloS One
Fred Sigernes, Mikko Syrjäsuo, Rune Storvold, João Fortuna, Mariusz Eivind Grøtte, Tor Arne Johansen
This study describes rapid prototype construction of small and lightweight push broom Hyper Spectral Imagers (HSI). The dispersive element housings are printed by a thermoplastic 3D printer combined with S-mount optical components and commercial off-the-shelf camera heads. Four models with a mass less than 200 g are presented with a spectral range in the visible to the near-infrared part of the electromagnetic spectrum. The bandpass is in the range from 1.4 - 5 nm. Three test experiments with motorized gimbals to stabilize attitude show that the instruments are capable of push broom spectral imaging from various platforms, including airborne drone to handheld operations...
March 5, 2018: Optics Express
Takuma Oide, Toru Abe, Takuo Suganuma
As smartphones and other small portable devices become more sophisticated and popular, opportunities for communication and information sharing among such device users have increased. In particular, since it is known that infrastructure-less device-to-device (D2D) communication platforms consisting only of such devices are excellent in terms of, for example, bandwidth efficiency, efforts are being made to merge their information sharing capabilities with conventional infrastructure. However, efficient multi-hop communication is difficult with the D2D communication protocol, and many conventional D2D communication platforms require modifications of the protocol and terminal operating systems (OSs)...
March 4, 2018: Sensors
Z Leguay, E Figueiredo, L Evrillus, V Jacques-Terracol, M Le Verger
INTRODUCTION: The choice of packaging is crucial for the sterility of a reusable medical device. The use-by dates for sterile barrier systems (SBSs) are currently determined solely on the basis of an empirical rating scale developed in 1985. The objective of our work is to validate in a scientific way this deadline for the use of SBS for heat-sealable sleeves and bags, with protective packaging. MATERIALS AND METHODS: Thirty SBSs were tested after different storage periods ; six, nine and twelve months...
February 22, 2018: Annales Pharmaceutiques Françaises
Alejandro Gallego, Rory O'Hara Murray, Barbara Berx, William R Turrell, C J Beegle-Krause, Mark Inall, Toby Sherwin, John Siddorn, Sarah Wakelin, Vasyl Vlasenko, Lars R Hole, Knut Frode Dagestad, John Rees, Lucy Short, Petter Rønningen, Charlotte E Main, Sebastien Legrand, Tony Gutierrez, Ursula Witte, Nicole Mulanaphy
As oil reserves in established basins become depleted, exploration and production moves towards relatively unexploited areas, such as deep waters off the continental shelf. The Faroe-Shetland Channel (FSC, NE Atlantic) and adjacent areas have been subject to increased focus by the oil industry. In addition to extreme depths, metocean conditions in this region characterise an environment with high waves and strong winds, strong currents, complex circulation patterns, sharp density gradients, and large small- and mesoscale variability...
February 2018: Marine Pollution Bulletin
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"