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https://www.readbyqxmd.com/read/29757470/sinus-augmentation-using-rhbmp-2-acs-in-a-mini-pig-model-influence-of-an-adjunctive-ceramic-bone-biomaterial
#1
Cristiano Susin, Jaebum Lee, Tiago Fiorini, Rubens Moreno de Freitas, Hsien-Chung Chiu, Hari S Prasad, Amanda N Buxton, Ulf Me Wikesjö
BACKGROUND: Recombinant human bone morphogenetic protein-2 in an absorbable collagen sponge carrier (rhBMP-2/ACS) has been shown to support significant bone formation when used to augment the maxillary sinus for implant dentistry. Nevertheless, bone biomaterials have been suggested to extend rhBMP-2/ACS with limited support of the merits of such approaches. OBJECTIVES: To evaluate local bone formation/dental implant osseointegration following implantation of rhBMP-2/ACS combined with a ceramic bone biomaterial using a mini-pig sinus augmentation model...
May 14, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29741710/response-to-short-term-cold-storage-for-eggs-of-agasicles-hygrophila-coleoptera-chrysomelidae-a-biological-control-agent-of-alligator-weed-alternanthera-philoxeroides-caryophyllales-amaranthaceae
#2
Yan-Hong Liu, Dong Jia, Xiao-Fang Yuan, Yuan-Xin Wang, Hsin Chi, Thomas James Ridsdill-Smith, Rui-Yan Ma
The alligator weed flea beetle, Agasicles hygrophila Selman & Vogt (Coleoptera: Chrysomelidae) has been used very successfully for the biological control of the widely-distributed invasive weed Alternanthera philoxeroides (Mart.) Griseb (Caryophyllales: Amaranthaceae). In order to extend the 'shelf life' of natural enemies released in biological control programs, cold storage has proven to be a valuable commercial procedure. To determine a suitable low temperature for storage of A. hygrophila, we conducted short-term cold storage treatments of eggs (4°C for 0...
May 8, 2018: Journal of Economic Entomology
https://www.readbyqxmd.com/read/29723490/controlled-release-of-gene-therapy-constructs-from-solid-scaffolds-for-therapeutic-applications-in-orthopedics
#3
Jagadeesh K Venkatesan, Céline Falentin-Daudré, Amélie Leroux, Véronique Migonney, Magali Cucchiarini
Injuries occurring in orthopedic tissues do not completely heal if left untreated due to their imperfect self abilities for spontaneous repair. As most of the current clinical treatments often fail to fully restore the damaged tissues, there is a critical need to develop potent alternatives to activate the processes of repair in sites of orthopedic lesions. In this regard, combining gene therapy approaches with tissue engineering procedures to generate therapeutic gene vector-guided delivery systems, especially those based on mechanically stable solid scaffolds, is an attractive strategy to provide off-the-shelf compounds for the convenient spatiotemporal expression of candidate agents in orthopedic tissue defects...
April 2018: Discovery Medicine
https://www.readbyqxmd.com/read/29706473/procedural-and-perioperative-results-in-patients-treated-with-fenestrated-endovascular-aneurysm-repair-planned-by-automated-software-in-a-physician-sponsored-investigational-device-exemption-trial-of-physician-modified-endografts
#4
Benjamin W Starnes, Billi Tatum, Niten Singh
OBJECTIVE: Fenestrated endovascular aneurysm repair (FEVAR) has been used successfully to treat patients with juxtarenal abdominal aortic aneurysms (JAAAs). Barriers to wide adoption of FEVAR include complexity in planning of fenestration locations on endografts. The purpose of this study was to validate the use of automated planning software to design fenestrated endografts and to treat patients with complex abdominal aortic aneurysms. METHODS: Patients with JAAA who were not candidates for open repair were enrolled into the automated planning arm of an ongoing investigational device exemption clinical trial and treated with FEVAR...
April 26, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29694937/migration-of-plasticizers-from-poly-vinyl-chloride-and-multilayer-infusion-bags-using-selective-extraction-and-gc-ms
#5
Zohra Haned, Saad Moulay, Silvia Lacorte
Flexible poly(vinyl chloride) (PVC) is widely used in the pharmaceutical industry for the manufacture of medical devices (tubes, probes, bags, primary packaging, etc.). The objective of the present study was to develop a procedure to evaluate the migration potential of nine plastic additives in aqueous infusion bags (NaCl 0.9% and glucose 5%): five phthalates, one adipate, two alkylphenols, and benzophenone. Two types of materials were analyzed: (i) new and outdated plasticized PVC (containing 40% of diethylhexyl phthalate DEHP); and (ii) tri-laminate polyethylene-polyamide-polypropylene, a multilayer material presumably exempt from DEHP...
April 12, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29688697/dual-suppression-effect-of-magnetic-induction-heating-and-microencapsulation-on-ice-crystallization-enables-low-cryoprotectant-vitrification-of-stem-cell-alginate-hydrogel-constructs
#6
Xiaoli Liu, Gang Zhao, Zhongrong Chen, Fazil Panhwar, Xiaoming He
Stem cells microencapsulated in hydrogel as stem cell-hydrogel constructs have wide applications in the burgeoning cell-based medicine. Due to their short shelf life at ambient temperature, long-term storage or banking of the constructs is essential to their "off-the-shelf" ready availability needed for their widespread applications. As a high-efficiency, easy-to-operate, low-toxic and low-cost method for long-term storage of the constructs, low-cryoprotectant (CPA) vitrification has attracted tremendous attention recently...
April 24, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29680298/experimental-evaluation-of-homemade-distal-stent-graft-fenestration-for-thoracic-endovascular-aortic-repair-of-type-a-dissection-by-a-transapical-approach
#7
Thomas Gandet, Anis Seghrouchni, Baris Ata Ozdemir, Guillaume Captier, Roland Demaria, Pierre Alric, Bernard Albat, Ludovic Canaud
OBJECTIVE: The use of off-the-shelf stent grafts for thoracic endovascular aortic repair of type A dissections is limited by variability in both the length of the ascending aorta and the location of the proximal intimal tear. This experimental study aimed to assess the feasibility of using a physician-modified thoracic aortic stent graft to treat acute type A dissection by a transapical cardiac approach. METHODS: The experiments were performed on six cadaveric human heart, ascending aorta, aortic arch, and descending aorta specimens...
April 18, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29673841/electrospun-silk-fibroin-fibers-for-storage-and-controlled-release-of-human-platelet-lysate
#8
Cataldo Pignatelli, Giovanni Perotto, Marta Nardini, Ranieri Cancedda, Maddalena Mastrogiacomo, Athanassia Athanassiou
Human platelet lysate (hPL) is a pool of growth factors and cytokines able to induce regeneration of different tissues. Despite its good potentiality as therapeutic tool for regenerative medicine applications, hPL has been only moderately exploited in this field. A more widespread adoption has been limited because of its rapid degradation at room temperature that decreases its functionality. Another limiting factor for its extensive use is the difficulty of handling the hPL gels. In this work, silk fibroin-based patches were developed to address several points: improving the handling of hPL, enabling their delivery in a controlled manner and facilitating their storage by creating a device ready to use with expanded shelf life...
April 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29669940/generation-and-testing-of-clinical-grade-exosomes-for-pancreatic-cancer
#9
Mayela Mendt, Sushrut Kamerkar, Hikaru Sugimoto, Kathleen M McAndrews, Chia-Chin Wu, Mihai Gagea, Sujuan Yang, Elena V Rodriges Blanko, Qian Peng, Xiaoyan Ma, Joseph R Marszalek, Anirban Maitra, Cassian Yee, Katayoun Rezvani, Elizabeth Shpall, Valerie S LeBleu, Raghu Kalluri
Exosomes are extracellular vesicles produced by all cells with a remarkable ability to efficiently transfer genetic material, including exogenously loaded siRNA, to cancer cells. Here, we report on a bioreactor-based, large-scale production of clinical-grade exosomes employing good manufacturing practice (GMP) standards. A standard operating procedure was established to generate engineered exosomes with the ability to target oncogenic Kras (iExosomes). The clinical-grade GMP iExosomes were tested in multiple in vitro and in vivo studies to confirm suppression of oncogenic Kras and an increase in the survival of several mouse models with pancreatic cancer...
April 19, 2018: JCI Insight
https://www.readbyqxmd.com/read/29666613/novel-biocontrol-methods-for-listeria-monocytogenes-biofilms-in-food-production-facilities
#10
REVIEW
Jessica A Gray, P Scott Chandry, Mandeep Kaur, Chawalit Kocharunchitt, John P Bowman, Edward M Fox
High mortality and hospitalization rates have seen Listeria monocytogenes as a foodborne pathogen of public health importance for many years and of particular concern for high-risk population groups. Food manufactures face an ongoing challenge in preventing the entry of L. monocytogenes into food production environments (FPEs) due to its ubiquitous nature. In addition to this, the capacity of L. monocytogenes strains to colonize FPEs can lead to repeated identification of L. monocytogenes in FPE surveillance...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29657467/painless-period-after-spitzy-shelf-operation-for-residual-hip-dysplasia-a-long-term-study-of-47-children-and-young-adults
#11
Anne Guro Vreim Holm, Olav Reikerås, Terje Terjesen
Objective: To study the effects of the Spitzy shelf operation on hip pain. Method: A modified Spitzy shelf procedure was performed in 60 hips with residual hip dysplasia. The mean age at surgery was 11.7 years (range 5.5-22.4 years). Results: Twenty-one hips had pain preoperatively. One year postoperatively 57 hips (95%) were painless. The mean postoperative painless period in patients with >10 years follow-up was 24.1 years (range 5...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29613819/information-pooling-bias-in-collaborative-security-incident-correlation-analysis
#12
Prashanth Rajivan, Nancy J Cooke
OBJECTIVE: Incident correlation is a vital step in the cybersecurity threat detection process. This article presents research on the effect of group-level information-pooling bias on collaborative incident correlation analysis in a synthetic task environment. BACKGROUND: Past research has shown that uneven information distribution biases people to share information that is known to most team members and prevents them from sharing any unique information available with them...
March 1, 2018: Human Factors
https://www.readbyqxmd.com/read/29605424/baseline-levels-of-environmental-genotoxicity-and-potential-confounding-factors-using-common-sole-solea-solea-as-sentinel-organism
#13
N Cuevas, I Zorita
Micronuclei (MN) and nuclear buds (NB) frequency was assessed monthly over a one-year period in erythrocytes of common soles (Solea solea) from the Basque continental shelf, a minor disturbed area, in order to determine baseline levels and potential biotic and abiotic confounding factors within biomonitoring purposes. Both genotoxic parameters presented seasonal variations, although only NB frequency was positively correlated with environmental variables (i.e. water temperature and salinity). On the contrary, MN and NB were not affected by age and gender...
March 21, 2018: Marine Environmental Research
https://www.readbyqxmd.com/read/29579908/quantitative-microbiological-risk-assessment-in-food-industry-theory-and-practical-application
#14
Jeanne-Marie Membré, Géraldine Boué
The objective of this article is to bring scientific background as well as practical hints and tips to guide risk assessors and modelers who want to develop a quantitative Microbiological Risk Assessment (MRA) in an industrial context. MRA aims at determining the public health risk associated with biological hazards in a food. Its implementation in industry enables to compare the efficiency of different risk reduction measures, and more precisely different operational settings, by predicting their effect on the final model output...
April 2018: Food Research International
https://www.readbyqxmd.com/read/29579899/use-of-fourier-transform-infrared-spectroscopy-for-monitoring-the-shelf-life-of-ham-slices-packed-with-probiotic-supplemented-edible-films-after-treatment-with-high-pressure-processing
#15
F Pavli, A A Argyri, G-J E Nychas, C Tassou, N Chorianopoulos
The aim of the present study was to investigate the potential use of Fourier transform infrared (FTIR) spectroscopy to quantify biochemical changes occurring in ham slices packed with probiotic supplemented edible films and treated with High Pressure Processing (HPP), in monitoring spoilage. Details regarding the data collection and experimental procedure were presented by Pavli et al. (2017). A series of Partial Least Squares (PLS) models were developed to correlate spectral data from FTIR analysis with ham spoilage during storage under vacuum at different temperatures (4, 8 and 12°C)...
April 2018: Food Research International
https://www.readbyqxmd.com/read/29552470/cartilage-repair-in-the-knee-using-umbilical-cord-wharton-s-jelly-derived-mesenchymal-stem-cells-embedded-onto-collagen-scaffolding-and-implanted-under-dry-arthroscopy
#16
Boguslaw Sadlik, Grzegorz Jaroslawski, Mariusz Puszkarz, Adrian Blasiak, Tomasz Oldak, Dominika Gladysz, Graeme P Whyte
Cell-based cartilage repair procedures are becoming more widely available and have shown promising potential to treat a wide range of cartilage lesion types and sizes, particularly in the knee joint. More recently, techniques have evolved from 2-step techniques that use autologous chondrocyte expansion to 1-step techniques that make use of mesenchymal stem cells (MSCs) embedded onto biocompatible scaffolding. Our 1-step technique has been further developed to provide cell-based cartilage repair using MSCs that have the potential to be used in an off-the-shelf manner, without the need for autologous tissue harvest...
January 2018: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29538720/a-note-on-g-estimation-of-causal-risk-ratios
#17
Oliver Dukes, Stijn Vansteelandt
G-estimation is a flexible, semiparametric approach for estimating exposure effects in epidemiologic studies. It has several underappreciated advantages over other propensity score-based methods popular in epidemiology, which we review in this article. However, it is rarely used in practice, due to a lack of off-the-shelf software. To rectify this, we show a simple trick for obtaining G-estimators of causal risk ratios using existing generalized estimating equations software. We extend the procedure to more complex settings with time-varying confounders...
May 1, 2018: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29522200/multistate-outbreak-of-salmonella-virchow-infections-linked-to-a-powdered-meal-replacement-product-united-states-2015-2016
#18
Kelly J Gambino-Shirley, Adiam Tesfai, Colin A Schwensohn, Cindy Burnett, Lori Smith, Jennifer M Wagner, Dana Eikmeier, Kirk Smith, Jolianne P Stone, Dawn Updike, Jonas Hines, Lauren N Shade, Beth Tolar, Tong-Jen Fu, Stelios Viazis, Sharon L Seelman, Kathryn Blackshear, Matthew E Wise, Karen P Neil
Background: Nontyphoidal Salmonella is the leading cause of bacterial gastroenteritis in the United States. Meal replacement products containing raw and 'superfood' ingredients have gained increasing popularity among consumers in recent years. In January 2016, we investigated a multistate outbreak of infections with a novel strain of Salmonella Virchow. Methods: Cases were defined using molecular subtyping procedures. Commonly reported exposures were compared with responses from healthy people interviewed in the 2006-2007 FoodNet Population Survey...
March 7, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29522024/evaluation-of-a-flow-cytometry-method-to-determine-size-and-real-refractive-index-distributions-in-natural-marine-particle-populations
#19
Jacopo Agagliate, Rüdiger Röttgers, Michael S Twardowski, David McKee
A flow cytometric (FC) method was developed to retrieve particle size distributions (PSDs) and real refractive index (nr ) information in natural waters. Geometry and signal response of the sensors within the flow cytometer (CytoSense, CytoBuoy b.v., Netherlands) were characterized to form a scattering inversion model based on Mie theory. The procedure produced a mesh of diameter and nr isolines where each particle is assigned the diameter and nr values of the closest node, producing PSDs and particle real refractive index distributions...
March 1, 2018: Applied Optics
https://www.readbyqxmd.com/read/29518068/update-dura-mater-graft-associated-creutzfeldt-jakob-disease-japan-1975-2017
#20
Ryusuke Ae, Tsuyoshi Hamaguchi, Yosikazu Nakamura, Masahito Yamada, Tadashi Tsukamoto, Hidehiro Mizusawa, Ermias D Belay, Lawrence B Schonberger
Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disorder that, according to the most well accepted hypothesis (1), is caused by replicating, transmissible, abnormal forms of a host-encoded prion protein (prions). Most CJD cases occur spontaneously (sporadic CJD) or are inherited (genetic CJD). Iatrogenic CJD can occur after exposure to prion-contaminated instruments or products in medical/surgical settings. Cadaveric dura mater graft-associated CJD (dCJD) accounts for a common form of iatrogenic CJD...
March 9, 2018: MMWR. Morbidity and Mortality Weekly Report
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