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norepinephrine,hemorrhagic shock

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https://www.readbyqxmd.com/read/27742030/clonidine-reduces-norepinephrine-and-improves-bone-marrow-function-in-a-rodent-model-of-lung-contusion-hemorrhagic-shock-and-chronic-stress
#1
Ines G Alamo, Kolenkode B Kannan, Harry Ramos, Tyler J Loftus, Philip A Efron, Alicia M Mohr
BACKGROUND: Propranolol has been shown previously to restore bone marrow function and improve anemia after lung contusion/hemorrhagic shock. We hypothesized that daily clonidine administration would inhibit central sympathetic outflow and restore bone marrow function in our rodent model of lung contusion/hemorrhagic shock with chronic stress. METHODS: Male Sprague-Dawley rats underwent 6 days of restraint stress after lung contusion/hemorrhagic shock during which the animals received clonidine (75 μg/kg) after the restraint stress...
October 11, 2016: Surgery
https://www.readbyqxmd.com/read/27667276/-the-effect-and-factors-associated-with-outcome-of-extracorporeal-membrane-oxygenation-in-refractory-cardiogenic-shock-patients
#2
R Q Zhu, C Z Liu, J H Lu, Y P Su, S C Wen, G J Nie, Y Z Hu, L E Zuo
Objective: To observe the clinical efficacy and factors associated with outcome of extracorporeal membrane oxygenation (ECMO) in refractory cardiogenic shock patients. Methods: Patients with refractory cardiogenic shock received ECMO treatment in our hospital from May 2013 to November 2015 were retrospectively analyzed. The clinical status before ECMO support, ECMO timing, complications and outcome were observed and analyzed.The hemodynamic data and the amount of vasoactive drugs at 2 hours before ECMO support and at 2, 6, 24 and 48 hours after ECMO support were collected and compared...
September 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/26958793/the-role-of-the-sensor-kinase-qsec-an-adrenergic-receptor-of-escherichia-coli-in-bacterial-translocation-during-hemorrhagic-shock
#3
Jun Meng, Yun-Chao Huang, Jie Huang, Kun Yang
BACKGROUND: Hemorrhagic shock results in ileal mucosa damage and intestinal bacterial translocation. Additionally, during hemorrhagic shock, norepinephrine levels increase. Past research has shown that the QseC sensor kinase of Escherichia coli modulates the quorum-sensing response to epinephrine and norepinephrine. Therefore, the aim of our study was to examine whether the absence of the ability of E. coli to sense epinephrine/norepinephrine would attenuate the bacterial translocation to extraintestinal organs in a rat model of hemorrhagic shock...
June 2016: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/26717108/diversity-of-vascular-reactivity-and-the-treatment-response-in-diabetic-hypertensive-hyperlipidemic-and-healthy-rats-subjected-to-hemorrhagic-shock
#4
Yue Wu, Yu Zhu, Xiang-Yun Chen, Liang-Ming Liu, Tao Li
The current diagnosis and treatment guidelines for severe trauma and shock are all for healthy population. Few studies focused on the pathophysiological features and treatments in metabolic diseases after severe trauma and shock. Vascular reactivity is significantly decreased after severe trauma and shock. Improving the vascular reactivity with arginine vasopressin (AVP) and phorbol-12 myristate-13-acetate (PMA) is beneficial to trauma and shock. Whether the cardiovascular function and treatment responses have the own features in hypertensive, diabetic, and hyperlipidemic patients after traumatic hemorrhagic shock is not known...
February 2016: Shock
https://www.readbyqxmd.com/read/26687560/inhibition-of-complement-c3-might-rescue-vascular-hyporeactivity-in-a-conscious-hemorrhagic-shock-rat-model
#5
Ding Chen, Meng-Qi Song, Yan-Jun Liu, Yin-Kai Xue, Ping Cheng, Hai Zheng, Li-Bo Chen
BACKGROUND: Vascular hyporeactivity in severe hemorrhagic shock could induce refractory hypotension and is an important cause of death. The global acute inflammatory response induced in shock triggers the over-expression of reactive oxygen species, NO, ET1 and TNF-α, which play essential roles in the pathology of vascular hyporeactivity. This leads to a hypothesis that inhibition of the complement system, the mediator of the inflammatory cascade, might be a promising therapeutic exploration for vascular hyporeactivity...
May 2016: Microvascular Research
https://www.readbyqxmd.com/read/26588829/effects-of-hyperoxia-and-mild-therapeutic-hypothermia-during-resuscitation-from-porcine-hemorrhagic-shock
#6
Elisabeth Knöller, Tatjana Stenzel, Friederike Broeskamp, Rouven Hornung, Angelika Scheuerle, Oscar McCook, Ulrich Wachter, Josef A Vogt, José Matallo, Martin Wepler, Holger Gässler, Michael Gröger, Martin Matejovic, Enrico Calzia, Lorenz Lampl, Michael Georgieff, Peter Möller, Pierre Asfar, Peter Radermacher, Sebastian Hafner
OBJECTIVE: Hemorrhagic shock-induced tissue hypoxia induces hyperinflammation, ultimately causing multiple organ failure. Hyperoxia and hypothermia can attenuate tissue hypoxia due to increased oxygen supply and decreased demand, respectively. Therefore, we tested the hypothesis whether mild therapeutic hypothermia and hyperoxia would attenuate postshock hyperinflammation and thereby organ dysfunction. DESIGN: Prospective, controlled, randomized study. SETTING: University animal research laboratory...
May 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/26375076/hem-14-effects-of-hyperoxia-and-mild-therapeutic-hypothermia-during-resuscitation-from-porcine-hemorrhagic-shock
#7
S Hafner, M Wepler, J Matallo, M Gröger, H Gässler, E Calzia, L Lampl, M Georgieff, P Radermacher, O McCook
INTRODUCTION: Hemorrhagic shock-induced tissue hypoxia induces hyper-inflammation, ultimately causing multiple organ failure. Hyperoxia and hypothermia can attenuate tissue hypoxia due to increased O2 supply and decreased demand, respectively. Therefore, we tested the hypothesis whether mild therapeutic hypothermia and hyperoxia would attenuate post-shock hyper-inflammation and thereby organ dysfunction. METHODS: After four hours of hemorrhage (removal of 30% of the blood volume, subsequent titration of mean arterial pressure (MAP) at 35 mmHg), anesthetized and instrumented pigs were randomly assigned to "control" (standard resuscitation: re-transfusion of shed blood, fluid resuscitation, norepinephrine titrated to maintain MAP at pre-shock values, mechanical ventilation titrated to maintain arterial O2 saturation > 90%), "hyperoxia" (standard resuscitation, but inspired O2 fraction (FiO2) 1...
October 2015: Shock
https://www.readbyqxmd.com/read/26209056/value-and-determinants-of-the-mean-systemic-filling-pressure-in-critically-ill-patients
#8
Xavier Repessé, Cyril Charron, Julia Fink, Alain Beauchet, Florian Deleu, Michel Slama, Guillaume Belliard, Antoine Vieillard-Baron
Mean systemic filling pressure (Pmsf) is a major determinant of venous return. Its value is unknown in critically ill patients (ICU). Our objectives were to report Pmsf in critically ill patients and to look for its clinical determinants, if any. We performed a prospective study in 202 patients who died in the ICU with a central venous and/or arterial catheter. One minute after the heart stopped beating, intravascular pressures were recorded in the supine position after ventilator disconnection. Parameters at admission, during the ICU stay, and at the time of death were prospectively collected...
September 2015: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/26175134/transfused-older-stored-red-blood-cells-improve-the-clinical-course-and-outcome-in-a-canine-lethal-hemorrhage-and-reperfusion-model
#9
Steven B Solomon, Irene Cortés-Puch, Junfeng Sun, Kenneth E Remy, Dong Wang, Jing Feng, Sameena S Khan, Derek Sinchar, Daniel B Kim-Shapiro, Harvey G Klein, Charles Natanson
BACKGROUND: In canine models, transfused older stored red blood cells (RBCs) hemolyze in vivo resulting in significantly increased intravascular cell-free hemoglobin (CFH) and non-transferrin-bound iron (NTBI). During canine bacterial pneumonia with septic shock, but not in controls, older stored RBCs were associated with significantly increased lung injury and mortality. It is unknown if in shock without infection transfusion of older RBCs will result in similar adverse effects. STUDY DESIGN AND METHODS: Two-year-old purpose-bred beagles (n = 12) were transfused similar quantities of either older (42-day) or fresher (7-day) stored universal donor canine RBCs 2...
November 2015: Transfusion
https://www.readbyqxmd.com/read/26091320/chronic-restraint-stress-after-injury-and-shock-is-associated-with-persistent-anemia-despite-prolonged-elevation-in-erythropoietin-levels
#10
Letitia E Bible, Latha V Pasupuleti, Amy V Gore, Ziad C Sifri, Kolenkode B Kannan, Alicia M Mohr
BACKGROUND: Following severe traumatic injury, critically ill patients have a prolonged hypercatacholamine state that is associated with bone marrow (BM) dysfunction and persistent anemia. However, current animal models of injury and shock result in a transient anemia. Daily restraint stress (chronic stress [CS]) has been shown to increase catecholamines. We hypothesize that adding CS following injury or injury and shock in rats will prolong the hypercatecholaminemia and prolong the initial anemia, despite elevated erythropoietin (EPO) levels...
July 2015: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/25782753/norepinephrine-decreases-fluid-requirements-and-blood-loss-while-preserving-intestinal-villi-microcirculation-during-fluid-resuscitation-of-uncontrolled-hemorrhagic-shock-in-mice
#11
Anatole Harrois, Nathalie Baudry, Olivier Huet, Hiromi Kato, Laurent Dupic, Manuel Lohez, Marianne Ziol, Eric Vicaut, Jacques Duranteau
BACKGROUND: Norepinephrine administration is controversial during hemorrhagic shock resuscitation to stabilize mean arterial pressure (MAP) level because it could have deleterious effects on local circulations. The authors investigated the effect of norepinephrine on intestinal microcirculation during fluid resuscitation in uncontrolled hemorrhagic shock. METHODS: Mice (n = 6 per group) submitted to an uncontrolled hemorrhagic shock by tail section were randomly assigned to a resuscitation with fluid but without norepinephrine to target a MAP level of 50 mmHg (FR50) or 60 mmHg (FR60) or a resuscitation with fluid and norepinephrine to target a MAP level of 50 mmHg (FRNE50) or 60 mmHg (FRNE60)...
May 2015: Anesthesiology
https://www.readbyqxmd.com/read/25752214/beneficial-effect-of-cyclosporine-a-on-traumatic-hemorrhagic-shock
#12
Yan Lei, Xiaoyong Peng, Liangming Liu, Zhaojun Dong, Tao Li
BACKGROUND: Vascular hyporeactivity plays an important role in severe trauma and shock. We investigated the beneficial effect of cyclosporine A (CsA) on traumatic shock and its relationship to vascular reactivity improvement and mitochondrial permeability transition pore (MPTP). MATERIALS AND METHODS: Sodium pentobarbital-anesthetized rats were used to induce traumatic hemorrhagic shock by left femur fracture and hemorrhage, the beneficial effects of CsA (1, 5, and 10 mg/kg, intravenously) on animal survival, cardiovascular function, tissue blood perfusion, and mitochondrial function of vital organs were observed...
May 15, 2015: Journal of Surgical Research
https://www.readbyqxmd.com/read/25565637/vasopressin-decreases-pulmonary-to-systemic-vascular-resistance-ratio-in-a-porcine-model-of-severe-hemorrhagic-shock
#13
Joy Sarkar, Patrick J Golden, Lauren N Kajiura, Lee-Ann M Murata, Catherine F T Uyehara
Vasopressors are gaining renewed interest as treatment adjuncts in hemorrhagic shock. The ideal vasoconstrictor will increase systemic blood pressure without increasing pulmonary vascular resistance (PVR), which hinders pulmonary perfusion and exacerbates hypoxemia. However, the selectivity of pressors for pulmonary versus systemic vasoconstriction during hemorrhage has not been characterized. The purpose of this study was to test the hypothesis that vasopressin (VP) has distinct effects on pulmonary versus systemic hemodynamics, unlike the catecholamine vasopressors norepinephrine (NE) and phenylephrine (PE)...
May 2015: Shock
https://www.readbyqxmd.com/read/25549679/-risk-factors-and-prognosis-of-hypotension-in-postoperative-sedation-patients
#14
Bo Tang, Xiaoting Wang, Dawei Liu, Hongmin Zhang, Huaiwu He
OBJECTIVE: To explore the risk factors and prognosis of hypotension in postoperative sedation patients. METHODS: A total of 175 patients with postoperative sedation at our department from May 2013 to March 2014 were retrospectively reviewed. Patients with age <18 years, cardiac surgery, pheochromocytoma surgery, hemorrhagic shock, septic shock or cardiogenic shock were excluded. APACHE II, dosage and duration of sedative drug, mean arterial pressure at baseline and after sedation, central venous pressure, fluid balance, dosage and duration of norepinephrine, endotracheal intubation time and length of intensive care unit (ICU) stay were recorded...
October 28, 2014: Zhonghua Yi Xue za Zhi
https://www.readbyqxmd.com/read/25390510/acute-macular-neuroretinopathy-an-atypical-case
#15
Maziar Lalezary, Scott D Schoenberger, Edward Cherney, Anita Agarwal
PURPOSE: The purpose of this report is to describe extensive acute macular neuroretinopathy lesions with atypical features. METHODS: Retrospective case report. RESULTS: A patient developed acute macular neuroretinopathy in the setting of multiple previously described associations including a flu-like illness, sympathomimetic exposure, overdose of norepinephrine reuptake inhibitors, anemia, thrombocytopenia, and hypotensive shock. The fundus lesions superficially resembled retinal hemorrhages in color and fluorescein angiography pattern...
2013: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/25263335/ryanodine-receptor-2-contributes-to-hemorrhagic-shock-induced-bi-phasic-vascular-reactivity-in-rats
#16
Rong Zhou, Xiao-li Ding, Liang-ming Liu
AIM: Ryanodine receptor 2 (RyR2) is a critical component of intracellular Ca(2+) signaling in vascular smooth muscle cells (VSMCs). The aim of this study was to investigate the role of RyR2 in abnormal vascular reactivity after hemorrhagic shock in rats. METHODS: SD rats were hemorrhaged and maintained mean arterial pressure (MAP) at 40 mmHg for 30 min or 2 h, and then superior mesenteric arteries (SMA) rings were prepared to measure the vascular reactivity. In other experiments, SMA rings of normal rats and rat VSMCs were exposed to a hypoxic medium for 10 min or 3 h...
November 2014: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/25254206/vasopressin-in-hemorrhagic-shock-a-systematic-review-and-meta-analysis-of-randomized-animal-trials
#17
REVIEW
Andrea Pasquale Cossu, Paolo Mura, Lorenzo Matteo De Giudici, Daniela Puddu, Laura Pasin, Maurizio Evangelista, Theodoros Xanthos, Mario Musu, Gabriele Finco
OBJECTIVE: The latest European guidelines for the management of hemorrhagic shock suggest the use of vasopressors (norepinephrine) in order to restore an adequate mean arterial pressure when fluid resuscitation therapy fails to restore blood pressure. The administration of arginine vasopressin (AVP), or its analogue terlipressin, has been proposed as an alternative treatment in the early stages of hypovolemic shock. DESIGN: A meta-analysis of randomized controlled animal trials...
2014: BioMed Research International
https://www.readbyqxmd.com/read/25250595/impact-of-epinephrine-and-norepinephrine-on-two-dynamic-indices-in-a-porcine-hemorrhagic-shock-model
#18
Raphaël Giraud, Nils Siegenthaler, Diego Arroyo, Karim Bendjelid
BACKGROUND: Pulse pressure variations (PPVs) and stroke volume variations (SVVs) are dynamic indices for predicting fluid responsiveness in intensive care unit patients. These hemodynamic markers underscore Frank-Starling law by which volume expansion increases cardiac output (CO). The aim of the present study was to evaluate the impact of the administration of catecholamines on PPV, SVV, and inferior vena cava flow (IVCF). METHODS: In this prospective, physiologic, animal study, hemodynamic parameters were measured in deeply sedated and mechanically ventilated pigs...
October 2014: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/24887726/vasopressor-use-during-emergency-trauma-surgery
#19
Robert M Van Haren, Chad M Thorson, Evan J Valle, Gerardo A Guarch, Jassin M Jouria, Alexander M Busko, Nicholas Namias, Alan S Livingstone, Kenneth G Proctor
Most evidence suggests early vasopressor use is associated with death after trauma, but no previous study has focused on patients requiring emergency operative intervention (OR). We test the hypothesis that vasopressors are harmful in this population. Records from 746 patients requiring OR from July 2009 to March 2013 were retrospectively reviewed and stratified based on vasopressor use (epinephrine [EPI], phenylephrine, ephedrine, norepinephrine, dobutamine, vasopressin) or no vasopressor use. Vasopressors were administered to 225 patients (30%) during OR; 59 patients (8%) received multiple vasopressors...
May 2014: American Surgeon
https://www.readbyqxmd.com/read/24855850/thai-shock-survey-2013-survey-of-shock-management-in-thailand
#20
Kaweesak Chittawatanarat, Boonsong Patjanasoontorn, Suthat Rungruanghiranya
OBJECTIVE: Pragmatic surveys for shock management by Thai physicians are unavailable. The objective of this study is to identify the shock management patterns on both; the incidence of septic shock and hemorrhagic shock here in Thailand. MATERIAL AND METHOD: Two thousand questionnaires were sent to physicians who are called on to care for patients in shock across Thailand. The questionnaire is composed of 58 items regarding all aspects of the management of septic and hemorrhagic shock...
January 2014: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
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