Shixun Han, Haonan Fan, Guoxuan Zhong, Lei Ni, Wenhao Shi, Yushan Fang, Chenliang Wang, Li Wang, Lang Song, Jianhui Zhao, Mei Tang, Bing Yang, Li Li, Xueli Bai, Qi Zhang, Tingbo Liang, Yanhui Xu, Xin-Hua Feng, Chen Ding, Dong Fang, Bin Zhao
BACKGROUND AND AIMS: Epigenetic reprogramming and escape from terminal differentiation are poorly understood enabling characteristics of liver cancer. Keratin 19 (KRT19), classically known to form the intermediate filament cytoskeleton, is a marker of stemness and worse prognosis in liver cancer. This study aimed to address the functional roles of KRT19 in liver tumorigenesis and to elucidate the underlying mechanisms. APPROACH AND RESULTS: Using multiplexed genome editing of hepatocytes in vivo, we demonstrated that KRT19 promoted liver tumorigenesis in mice...
April 1, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases