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https://www.readbyqxmd.com/read/27916472/generation-of-neural-cells-using-ipscs-from-sleep-bruxism-patients-with-5-ht2a-polymorphism
#1
Yurie Hoashi, Satoshi Okamoto, Yuka Abe, Takashi Matsumoto, Junichi Tanaka, Yuya Yoshida, Kent Imaizumi, Kenji Mishima, Wado Akamatsu, Hideyuki Okano, Kazuyoshi Baba
PURPOSE: Sleep bruxism (SB) is classified as a sleep-related movement disorder characterized by grinding and clenching of the teeth during sleep, which is responsible for a variety of clinical problems such as abnormal tooth attrition and fracture of teeth or roots. Little is known about the etiology of SB. Our previous study identified a genomic association of the serotonin 2A receptor (5-HT2A) single nucleotide polymorphism (SNP), rs6313 C>T, with SB, where the C allele carrier is associated with a 4...
December 1, 2016: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/27914227/removal-of-supernumerary-teeth-utilizing-a-computer-aided-design-computer-aided-manufacturing-surgical-guide
#2
Chanwoo Jo, Doohwan Bae, Byungho Choi, Jihun Kim
Supernumerary teeth need to be removed because they can cause various complications. Caution is needed because their removal can cause damage to permanent teeth or tooth germs in the local vicinity. Surgical guides have recently been used in maxillofacial surgery. Because surgical guides are designed through preoperative analysis by computer-aided design software and fabricated using a 3-dimensional printer applying computer-aided manufacturing technology, they increase the accuracy and predictability of surgery...
November 12, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27895346/association-between-hypodontia-and-angles-malocclusion
#3
Batool Ali, Syed Sheeraz Hussain
This study was planned to determine the prevalence of hypodontia in permanent dentition and to test whether an association was present between hypodontia and Angle's malocclusion. The retrospective study was conducted at a tertiary care hospital, Karachi, and comprised record of all patients visiting the orthodontic clinics of the hospital from 2005 to 2015. Orthodontic records of 790(79%) subjects, including 189(23.9%) males and 601(76.1%) females, were reviewed. Their mean age was 17 ± 5.06 years. A tooth was considered missing if no evidence of tooth germ was observed on orthopantomograms and dental casts...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27859616/immunohistochemical-expression-of-podoplanin-d2-40-lymphangiogenesis-and-neoangiogenesis-in-tooth-germ-ameloblastomas-and-ameloblastic-carcinomas
#4
Celeste Sánchez-Romero, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Oslei Paes de Almeida
BACKGROUND: Ameloblastoma is a benign but locally aggressive odontogenic tumor, while ameloblastic carcinoma is its malignant counterpart. Angiogenesis and lymphangiogenesis in malignancies have been correlated with higher aggressiveness and poor prognosis, as well as greater expression of podoplanin by tumoral cells. METHODS: Immunohistochemical expression of podoplanin, CD34, and CD105 (endoglin) was evaluated in 53 ameloblastomas and three ameloblastic carcinomas; additionally, immunohistochemistry for podoplanin was also performed in 10 tooth germs...
November 10, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27835837/microrna-control-of-tooth-formation-and-eruption
#5
REVIEW
Ying Jin, Chenglin Wang, Si Cheng, Zhihe Zhao, Juan Li
Tooth development involves epithelium invagination, mesenchyme aggregation, and epithelium-mesenchyme communication. A sophisticated signaling pathway network regulates the differentiation and crosstalk of multiple cell types in tooth germs and coordinates the broad spectrum of complex processes. MicroRNAs (miRNAs), a class of small non-coding RNA species that have been relatively well studied over the last few years, are now proposed as important regulators of tooth developmental signaling pathways as they repress cellular protein levels to provide a posttranscriptional gene regulation...
January 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/27816431/-mandibular-ameloblastic-fibro-odontoma-in-3-year-old-patient
#6
G Royer, R Lan, J Garçonnet, F Cheynet
INTRODUCTION: The ameloblastic fibro-odontoma (FOA) is a rare benign tumor representing 1-3% of odontogenic tumors. The FOA affects young patients before the age of 20. Surgical treatment allows usually for recovery. Recurrence and malignant transformation are possible. OBSERVATION: A 3-year-old patient, with no medical and surgical history, was referred for a painless swelling of the right cheek progressing for several months. Radiographic examination showed a large mixed lesion...
December 2016: Revue de Stomatologie, de Chirurgie Maxillo-faciale et de Chirurgie Orale
https://www.readbyqxmd.com/read/27812891/hypodontia-of-all-primary-canines
#7
R P Anthonappa, N M King
BACKGROUND: Several hypotheses have been proposed to explain hypodontia of the various tooth types with evolutionary and anatomic models. Hypodontia of all primary canines in a healthy individual is exceptionally rare and has not been previously reported in the dental literature. CASE REPORT: This clinical report describes a 4-year-old southern Chinese female with the congenital absence of the primary canines in all quadrants. Furthermore, all of the permanent tooth germs excluding the third molars were evident on a panoramic radiograph and were developing consistent with the subject's chronological age...
November 3, 2016: European Archives of Paediatric Dentistry: Official Journal of the European Academy of Paediatric Dentistry
https://www.readbyqxmd.com/read/27767053/globoside-accelerates-the-differentiation-of-dental-epithelial-cells-into-ameloblasts
#8
Takashi Nakamura, Yuta Chiba, Masahiro Naruse, Kan Saito, Hidemitsu Harada, Satoshi Fukumoto
Tooth crown morphogenesis is tightly regulated by the proliferation and differentiation of dental epithelial cells. Globoside (Gb4), a globo-series glycosphingolipid, is highly expressed during embryogenesis as well as organogenesis, including tooth development. We previously reported that Gb4 is dominantly expressed in the neutral lipid fraction of dental epithelial cells. However, because its functional role in tooth development remains unknown, we investigated the involvement of Gb4 in dental epithelial cell differentiation...
October 21, 2016: International Journal of Oral Science
https://www.readbyqxmd.com/read/27715429/integration-of-tooth-morphogenesis-and-innervation-by-local-tissue-interactions-signaling-networks-and-semaphorin-3a
#9
Keijo Luukko, Päivi Kettunen
The tooth, like many other organs, develops from both epithelial and mesenchymal tissues, and has proven to be a valuable tool with which to investigate organ formation and peripheral innervation. Tooth formation is regulated by local epithelial-mesenchymal tissue interactions, and is closely integrated with stereotypic dental nerve navigation and patterning. Recent analyses of the function and regulation of semaphorin 3A (SEMA3A) have shed light on the regulatory mechanisms that coordinate organogenesis and innervation at the tissue and molecular levels...
August 9, 2016: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/27713059/bmp4-msx1-signaling-and-osr2-control-tooth-organogenesis-through-antagonistic-regulation-of-secreted-wnt-antagonists
#10
Shihai Jia, Hyuk-Jae Edward Kwon, Yu Lan, Jing Zhou, Han Liu, Rulang Jiang
Mutations in MSX1 cause craniofacial developmental defects, including tooth agenesis, in humans and mice. Previous studies suggest that Msx1 activates Bmp4 expression in the developing tooth mesenchyme to drive early tooth organogenesis. Whereas Msx1(-/-) mice exhibit developmental arrest of all tooth germs at the bud stage, mice with neural crest-specific inactivation of Bmp4 (Bmp4(ncko)(/ncko)), which lack Bmp4 expression in the developing tooth mesenchyme, showed developmental arrest of only mandibular molars...
December 1, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27672006/p75-neurotrophin-receptor-regulates-differential-mineralization-of-rat-ectomesenchymal-stem-cells
#11
Kun Yang, Yingying Wang, Yingxin Ju, Gang Li, Chang Liu, Junyu Liu, Qi Liu, Xiujie Wen, Lu Chuan Liu
OBJECTIVES: The aim of this study was to investigate whether p75NTR (p75 neurotrophin receptor) regulates differential mineralization capacity of rEMSCs (rat ectomesenchymal stem cells) and underlying mechanisms associated with Mage-D1 (melanoma-associated antigens-D1). MATERIALS AND METHODS: Immunohistochemical staining of p75NTR in developing tooth germs was performed on E12.5d (embryonic 12.5 days) and E19.5d (embryonic 19.5 days). E12.5d EMSCs and E19.5d EMSCs were isolated in the same pregnant Sprague-Dawley rats from embryonic maxillofacial processes and tooth germs...
September 27, 2016: Cell Proliferation
https://www.readbyqxmd.com/read/27665981/expression-of-wilms-tumor-1-wt1-in-ameloblastomas
#12
Ronell Bologna-Molina, Yasunori Takeda, Takahisa Kuga, Naoyuki Chosa, Masae Kitagawa, Takashi Takata, Akira Ishisaki, Toshinari Mikami
The Wilms' tumor 1 gene (WT1) was originally isolated and described as the gene responsible for Wilms' tumor. Although there is growing evidence linking the overexpression of WT1 to tumorigenesis, no reports on ameloblastoma are available at present. The aim of this study was to examine the expression of WT1 in various histological subtypes of ameloblastoma tissue specimens and in human ameloblastoma cell lines. Immunohistochemical analyses were performed on a total of 168 cases of ameloblastoma, one case of ameloblastic carcinoma, and five cases of tooth germs (control)...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/27662194/the-patterning-cascade-model-and-carabelli-s-trait-expression-in-metameres-of-the-mixed-human-dentition-exploring-a-morphogenetic-model
#13
Kathleen S Paul, Claudia M Astorino, Shara E Bailey
OBJECTIVES: The Patterning Cascade Model (PCM) provides an evolutionary developmental framework for exploring diversity in tooth crown form. According to the model, proximity of secondary enamel knots and tooth germ size track underlying developmental processes that dictate ultimate crown morphology (i.e., cusp number, accessory cusp presence/size). Previous research has shown the model to successfully predict variation in Carabelli's trait expression between antimeric and metameric pairs of human permanent molars...
September 23, 2016: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/27611193/one-odontogenic-cell-population-contributes-to-the-development-of-the-mouse-incisors-and-of-the-oral-vestibule
#14
Maria Hovorakova, Katerina Lochovska, Oldrich Zahradnicek, Kristina Domonkosova Tibenska, Michaela Dornhoferova, Lucie Horakova-Smrckova, Silvia Bodorikova
The area of the oral vestibule is often a place where pathologies appear (e.g., peripheral odontomas). The origin of these pathologies is not fully understood. In the present study, we traced a cell population expressing Sonic hedgehog (Shh) from the beginning of tooth development using Cre-LoxP system in the lower jaw of wild-type (WT) mice. We focused on Shh expression in the area of the early appearing rudimentary incisor germs located anteriorly to the prospective incisors. The localization of the labelled cells in the incisor germs and also in the inner epithelial layer of the vestibular anlage showed that the first very early developmental events in the lower incisor area are common to the vestibulum oris and the prospective incisor primordia in mice...
2016: PloS One
https://www.readbyqxmd.com/read/27602397/antimicrobial-activity-of-peganum-harmala-l-on-streptococcus-mutans-compared-to-0-2-chlorhexidine
#15
Mohammad Motamedifar, Hengameh Khosropanah, Shima Dabiri
STATEMENT OF THE PROBLEM: Dental caries is one the most prevalent diseases that affects humans throughout their lives. Streptococcus mutans (S. mutans) is recognized as the most important microorganism during tooth cariogenicity. Reducing this germ in oral cavity can reduce the rate of tooth decays in humans. PURPOSE: The present study compared the antimicrobial activity of ethanolic extract of Peganum harmala L. seeds and 0.2% chlorhexidine on S. mutans. MATERIALS AND METHOD: Agar diffusion technique and micro broth dilution method were employed to test the antimicrobial effects of these two agents on S...
September 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27600358/the-differentiation-potential-of-gingival-mesenchymal-stem-cells-induced-by-apical-tooth-germ-cell%C3%A2-conditioned-medium
#16
Yan Chen, Hongwei Liu
Gingival-derived mesenchymal stem cells (GMSCs) have recently been harvested; however, the use of GMSCs in periodontal tissue engineering requires further study. The present study established an indirect co‑culture system between rat apical tooth germ‑conditioned medium (APTG‑CM) and GMSCs, in order to determine the effects on periodontal tissue differentiation in vitro and in vivo. Using the limiting dilution technique, single‑colony derived human GMSCs and periodontal ligament stem cells (PDLSCs) were isolated and expanded to obtain homogeneous populations...
October 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27590885/altered-tooth-morphogenesis-after-silencing-the-planar-cell-polarity-core-component-vangl2
#17
Zhaoming Wu, Don Jeevanie Epasinghe, Jinquan He, Liwen Li, David W Green, Min-Jung Lee, Han-Sung Jung
Vangl2, one of the core components of the planar cell polarity (PCP) pathway, has an important role in the regulation of morphogenesis in several tissues. Although the expression of Vangl2 has been detected in the developing tooth, its role in tooth morphogenesis is not known. In this study, we show that Vangl2 is expressed in the inner dental epithelium (IDE) and in the secondary enamel knots (SEKs) of bell stage tooth germs. Inhibition of Vangl2 expression by siRNA treatment in in vitro-cultured tooth germs resulted in retarded tooth germ growth with deregulated cell proliferation and apoptosis...
September 3, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27588418/coordination-of-cellular-dynamics-contributes-to-tooth-epithelium-deformations
#18
Ritsuko Morita, Miho Kihira, Yousuke Nakatsu, Yohei Nomoto, Miho Ogawa, Kazumasa Ohashi, Kensaku Mizuno, Tetsuhiko Tachikawa, Yukitaka Ishimoto, Yoshihiro Morishita, Takashi Tsuji
The morphologies of ectodermal organs are shaped by appropriate combinations of several deformation modes, such as invagination and anisotropic tissue elongation. However, how multicellular dynamics are coordinated during deformation processes remains to be elucidated. Here, we developed a four-dimensional (4D) analysis system for tracking cell movement and division at a single-cell resolution in developing tooth epithelium. The expression patterns of a Fucci probe clarified the region- and stage-specific cell cycle patterns within the tooth germ, which were in good agreement with the pattern of the volume growth rate estimated from tissue-level deformation analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27536251/expression-of-nerve-growth-factor-ngf-trka-and-p75-ntr-in-developing-human-fetal-teeth
#19
Thimios A Mitsiadis, Pierfrancesco Pagella
Nerve growth factor (NGF) is important for the development and the differentiation of neuronal and non-neuronal cells. NGF binds to specific low- and high-affinity cell surface receptors, respectively, p75(NTR) and TrkA. In the present study, we examined by immunohistochemistry the expression patterns of the NGF, p75(NTR), and TrkA proteins during human fetal tooth development, in order to better understand the mode of NGF signaling action in dental tissues. The results obtained show that these molecules are expressed in a wide range of dental cells of both epithelial and mesenchymal origin during early stages of odontogenesis, as well as in nerve fibers that surround the developing tooth germs...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27518316/antagonistic-functions-of-usag-1-and-runx2-during-tooth-development
#20
Yumiko Togo, Katsu Takahashi, Kazuyuki Saito, Honoka Kiso, Hiroko Tsukamoto, Boyen Huang, Motoko Yanagita, Manabu Sugai, Hidemitsu Harada, Toshihisa Komori, Akira Shimizu, Mary MacDougall, Kazuhisa Bessho
Supernumerary teeth and tooth agenesis are common morphological anomalies in humans. We previously obtained evidence that supernumerary maxillary incisors form as a result of the successive development of the rudimentary maxillary incisor tooth germ in Usag-1 null mice. The development of tooth germs is arrested in Runx2 null mice, and such mice also exhibit lingual epithelial buds associated with the upper molars and incisors. The aim of this study is to investigate the potential crosstalk between Usag-1 and Runx2 during tooth development...
2016: PloS One
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