keyword
MENU ▼
Read by QxMD icon Read
search

tooth germ

keyword
https://www.readbyqxmd.com/read/29148101/homeobox-protein-msx-1-inhibits-expression-of-bone-morphogenetic-protein-2-bone-morphogenetic-protein-4-and-lymphoid-enhancer-binding-factor-1-via-wnt-%C3%AE-catenin-signaling-to-prevent-differentiation-of-dental-mesenchymal-cells-during-the-late-bell-stage
#1
Xiao-Yu Feng, Xiao-Shan Wu, Jin-Song Wang, Chun-Mei Zhang, Song-Lin Wang
Homeobox protein MSX-1 (hereafter referred to as MSX-1) is essential for early tooth-germ development. Tooth-germ development is arrested at bud stage in Msx1 knockout mice, which prompted us to study the functions of MSX-1 beyond this stage. Here, we investigated the roles of MSX-1 during late bell stage. Mesenchymal cells of the mandibular first molar were isolated from mice at embryonic day (E)17.5 and cultured in vitro. We determined the expression levels of β-catenin, bone morphogenetic protein 2 (Bmp2), Bmp4, and lymphoid enhancer-binding factor 1 (Lef1) after knockdown or overexpression of Msx1...
November 17, 2017: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29129749/quantitative-proteomic-analysis-of-deciduous-molars-during-cap-to-bell-transition-in-miniature-pig
#2
Yang Li, Yiyi Gong, Xiaoshan Wu, Fu Wang, Yilin Xie, Zhao Zhu, Yingying Su, Jinsong Wang, Chunmei Zhang, Junqi He, Haiteng Deng, Songlin Wang
Taking advantage of genetic manipulation tools and accessibility, almost all molecular knowledge on vertebrate tooth development was obtained from rodent models that only have one dentition in their entire lives. Whether the tooth development in other vertebrates such as swine or human follows the same rules remains elusive. Rodent dentitions differ considerably from human dentitions, therefore limiting the application of knowledge from rodent tooth to human tooth. Signal-mediated communication between cells and complex gene and protein regulatory networks are key components of tooth development...
November 9, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/29090496/primordial-odontogenic-tumor-a-case-report-with-histopathological-analyses
#3
Toshinari Mikami, Yu Ohashi, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Naoki Fujiwara, Naoko Tsunoda, Hiroyuki Yamada, Yasunori Takeda
Primordial odontogenic tumor (POT) is a benign mixed epithelial and mesenchymal odontogenic tumor included into the current World Health Organization (WHO) classification of Head and Neck tumours in 2017. As far as the authors have confirmed, only eight cases of this tumor have been reported so far. This paper reports a case of POT that occurred in the right mandible of a 5-year-old patient. Panoramic radiograph showed a well-defined homogeneous radiolucency displacing the unerupted second deciduous molar to the deep part of the mandible...
November 1, 2017: Pathology International
https://www.readbyqxmd.com/read/29090126/multidisciplinary-management-of-a-fused-maxillary-central-incisor-moved-through-the-midpalatal-suture-a-case-report
#4
Hakan Bulut, Aylin Pasaoglu
Fusion of teeth is a developmental anomaly. It occurs at the stage of tooth formation, which determines the shape and size of the tooth crown, when one or more teeth fuse at the dentin level during the morphodifferentiation of the dental germs. Such teeth show macrodontia and may cause crowding, as well as esthetic and endodontic problems. In this article, we report a rare case of a maxillary central incisor fused to a supernumerary tooth showing labial and palatal talon cusps, which was orthodontically moved across the midpalatal suture...
November 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/29072251/conservative-surgical-treatment-of-the-jaw-cysts-in-children-case-study-of-five-patients
#5
G Gurler, S Yilmaz, C Delilbasi, E Dilaver, E Yuzbasioglu, A Patir-Munevveroglu
AIMS: Conservative treatment of jaw cysts establishes low surgical complication risk and protects vital anatomical structures such as inferior alveolar nerve, maxillary sinus and permanent tooth germs. Marsupialization and decompression have been widely used in children. The aim of this study was to evaluate the results of the conservative treatment of jaw cysts in five children. MATERIALS AND METHODS: This article presents case series of marsupialization in jaw cysts associated with impacted teeth in five children...
September 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/29034895/generation-of-induced-pluripotent-stem-cell-ipsc-line-from-charcot-marie-tooth-disease-patient-with-mpz-mutation-cmt1b
#6
Daryeon Son, Phil Jun Kang, Wonjin Yun, Seungkwon You
Charcot-Marie-Tooth disease (CMT1B) is an inherited neurological disorder caused by mutation of the myelin protein zero (MPZ) gene. We generated an induced pluripotent stem cell (iPSC) line from an 81-year-old patient with CMT1B by electroporating of lymphoblastoid cell lines with episomal plasmids encoding OCT4, SOX2, KLF4, L-MYC, LIN28, and p53-targeting shRNA. The established iPSCs expressed various pluripotency markers, demonstrated the potential to differentiate into cells of the three germ layers in vitro, had a normal karyotype and retained the MPZ mutation...
October 2017: Stem Cell Research
https://www.readbyqxmd.com/read/28955954/lgr4-is-required-for-sequential-molar-development
#7
Yukiko Yamakami, Koki Kohashi, Kazunori Oyama, Yasuaki Mohri, Shizu Hidema, Katsuhiko Nishimori
Tooth development requires proliferation, differentiation, and specific migration of dental epithelial cells, through well-organized signaling interactions with mesenchymal cells. Recently, it has been reported that leucine-rich repeat-containing G protein coupled receptor 4 (LGR4), the receptor of R-spondins, is expressed in many epithelial cells in various organs and tissues and is essential for organ development and stem cell maintenance. Here, we report that LGR4 contributes to the sequential development of molars in mice...
December 2016: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28942297/ameloblastoma-of-the-jaw-in-three-species-of-rodent-a-domestic-brown-rat-rattus-norvegicus-syrian-hamster-mesocricetus-auratus-and-amargosa-vole-microtus-californicus-scirpensis
#8
B Murphy, A Michel, E B LaDouceur, C Bell, M Lin, D M Imai
Ameloblastoma is a locally aggressive tumour derived from the odontogenic epithelium of the developing tooth germ. This uncommon odontogenic tumour is generally considered benign, but rarely, both distant metastasis and cytological atypia occur and this malignant version is referred to as malignant ameloblastic carcinoma. Here we document a spontaneous malignant ameloblastic carcinoma in a rat (Rattus norvegicus) with metastasis to the submandibular lymph node. We also describe ameloblastomas in two other muroid rodents, an Amaragosa vole (Microtus californicus scirpensis) and a Syrian hamster (Mesocricetus auratus)...
August 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28933666/regulation-of-proliferation-in-developing-human-tooth-germs-by-msx-homeodomain-proteins-and-cyclin-dependent-kinase-inhibitor-p19-ink4d
#9
Darko Kero, Katarina Vukojevic, Petra Stazic, Danijela Sundov, Snjezana Mardesic Brakus, Mirna Saraga-Babic
Before the secretion of hard dental tissues, tooth germs undergo several distinctive stages of development (dental lamina, bud, cap and bell). Every stage is characterized by specific proliferation patterns, which is regulated by various morphogens, growth factors and homeodomain proteins. The role of MSX homeodomain proteins in odontogenesis is rather complex. Expression domains of genes encoding for murine Msx1/2 during development are observed in tissues containing highly proliferative progenitor cells. Arrest of tooth development in Msx knockout mice can be attributed to impaired proliferation of progenitor cells...
October 2, 2017: Organogenesis
https://www.readbyqxmd.com/read/28928009/oropharyngeal-epignathus-with-partial-facial-duplication-report-of-a-rare-case
#10
M Herath, B S M S Siriwardena, R D Jayasinghe, D K Dias
Foetal oral teratoma or epignathus is a rare benign condition that originates in the oropharyngeal region. The term 'teratoma' refers to a mass composed of poorly organized tissues derived from each of the three germ layers. Epignathus may occur when one twin ceases development during gestation and becomes vestigial to the fully formed dominant twin. The reported incidence of epignathus is approximately 1:35,000 to 1:200,000 live births. A unique case of partial facial duplication with gross histological and radiological evidence of partial duplication of the facial elements and organs is presented herein...
September 16, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28914240/comparison-of-candida-species-isolated-from-children-with-and-without-early-childhood-caries-a-descriptive-cross-sectional-study
#11
M S Beena, Faizal C Peedikayil, M B GufranAfmed, T P Chandru, K Soni, N Dhanesh
BACKGROUND: Early childhood caries (ECC) is characterized by the presence of one or more decayed, missing (due to caries), or filled teeth surfaces in any primary tooth, in a child below 6 years of age. Although ECC is primarily associated with high levels of maternal Streptococcus mutans, there has been an increased interest in finding the relationship between oral fungal flora and dental caries. OBJECTIVE: The aim of the study is to identify and characterize the Candida species and to compare the candidal isolates in children with ECC and without ECC...
October 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28892649/expression-of-phosphate-transporters-during-dental-mineralization
#12
L Merametdjian, S Beck-Cormier, N Bon, G Couasnay, S Sourice, J Guicheux, C Gaucher, L Beck
The importance of phosphate (Pi) as an essential component of hydroxyapatite crystals suggests a key role for membrane proteins controlling Pi uptake during mineralization in the tooth. To clarify the involvement of the currently known Pi transporters (Slc17a1, Slc34a1, Slc34a2, Slc34a3, Slc20a1, Slc20a2, and Xpr1) during tooth development and mineralization, we determined their spatiotemporal expression in murine tooth germs from embryonic day 14.5 to postnatal day 15 and in human dental samples from Nolla stages 6 to 9...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28880717/bivalent-histone-codes-on-wnt5a-during-odontogenic-differentiation
#13
Y Zhou, L Zheng, F Li, M Wan, Y Fan, X Zhou, W Du, C Pi, D Cui, B Zhang, J Sun, X Zhou
Lineage-committed differentiation is an essential biological program during odontogenesis, which is tightly regulated by lineage-specific genes. Some of these genes are modified by colocalization of H3K4me3 and H3K27me3 marks at promoter regions in progenitors. These modifications, named "bivalent domains," maintain genes in a poised state and then resolve for later activation or repression during differentiation. Wnt5a has been reported to promote odontogenic differentiation in dental mesenchyme. However, relatively little is known about the epigenetic modulations on Wnt5a activation during tooth development...
September 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28832934/relative-tooth-size-at-birth-in-primates-life-history-correlates
#14
Timothy D Smith, Magdalena N Muchlinski, Wade R Bucher, Christopher J Vinyard, Christopher J Bonar, Sian Evans, Lawrence E Williams, Valerie B DeLeon
OBJECTIVES: Dental eruption schedules have been closely linked to life history variables. Here we examine a sample of 50 perinatal primates (28 species) to determine whether life history traits correlate with relative tooth size at birth. MATERIALS AND METHODS: Newborn primates were studied using serial histological sectioning. Volumes of deciduous premolars (dp(2) -dp(4) ), replacement teeth (if any), and permanent molars (M(1-2/3) ) of the upper jaw were measured and residuals from cranial length were calculated with least squares regressions to obtain relative dental volumes (RDVs)...
November 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28782241/a-novel-mutation-of-adenomatous-polyposis-coli-apc-gene-results-in-the-formation-of-supernumerary-teeth
#15
Fang Yu, Wenping Cai, Beizhan Jiang, Laijun Xu, Shangfeng Liu, Shouliang Zhao
Supernumerary teeth are teeth that are present in addition to normal teeth. Although several hypotheses and some molecular signalling pathways explain the formation of supernumerary teeth, but their exact disease pathogenesis is unknown. To study the molecular mechanisms of supernumerary tooth-related syndrome (Gardner syndrome), a deeper understanding of the aetiology of supernumerary teeth and the associated syndrome is needed, with the goal of inhibiting disease inheritance via prenatal diagnosis. We recruited a Chinese family with Gardner syndrome...
August 7, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28776953/establishment-of-oral-bacterial-communities-in-germ-free-mice-and-the-influence-of-recipient-age
#16
Yingying Wu, Caroline Westwater, E Xiao, Jôice Dias Corrêa, Wenmei Xiao, Dana T Graves
The acquisition of the oral microbiome is a complex process. We examined how the timing of microbial exposure alters bacterial colonization of the tooth surface. Germ-free mice were conventionalized by exposure to specific pathogen free (SPF) mice to acquire a commensal microbiome over three distinct four week periods, 0-4 weeks of age (Conv0-4w), 4-8 weeks (Conv4-8w), or 8-12 weeks (Conv8-12w). Bacterial DNA was extracted from the tooth surface and analyzed by 16S rDNA sequencing. Total bacteria and inflammatory cytokine expression in gingiva were determined by quantitative real-time PCR...
August 4, 2017: Molecular Oral Microbiology
https://www.readbyqxmd.com/read/28762352/a-comparative-study-to-associate-the-presence-of-neonatal-line-in-deciduous-teeth-of-infants-with-the-occurrence-of-live-birth
#17
Shruti Srinivasan, Prashanth Sadashiva Murthy, Seema Deshmukh, N M Shamsundar
CONTEXT: The prominent striae of retzius corresponding to the occurrence of live birth is known as the neonatal line (NNL). The very presence of this line indicates the exposure of the infant to the stressful event of birth. AIMS: The study was aimed at locating the NNL in the developing primary teeth of the neonate and associating the presence of NNL to the occurrence of live birth. MATERIALS AND METHODS: The donated bodies of the neonates were taken, and a surgical incision was made along the crest of the alveolar ridge in the maxillary anterior region, enabling the careful removal of the tooth germs from within the jaw segment...
July 2017: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/28756608/inhibition-of-chondroitin-sulfate-glycosaminoglycans-incorporation-affected-odontoblast-differentiation-in-cultured-embryonic-mouse-molars
#18
Lipei Liu, Weiting Chen, Lefeng Li, Fangfang Xu, Beizhan Jiang
Chondroitin sulfate proteoglycan (CSPG) is an important component of extracellular matrix (ECM), it is composed of a core protein and one or more chondroitin sulfate glycosaminoglycan side chains (CS-GAGs). To investigate the roles of its CS-GAGs in dentinogenesis, the mouse mandibular first molar tooth germs at early bell stage were cultivated with or without β-xyloside. As expected, the CS-GAGs were inhibited on their incorporation to CSPGs by β-xyloside, accompanied by the change of morphology of the cultured tooth germs...
December 2017: Journal of Molecular Histology
https://www.readbyqxmd.com/read/28734144/expression-of-planar-cell-polarity-genes-during-mouse-tooth-development
#19
Nobuko Obara, Yuko Suzuki, Kazuharu Irie, Shunichi Shibata
OBJECTIVE: Planar cell polarity (PCP) refers to the cell polarity across the tissue plane and controls various cell behaviors and structures. Although the expression of several PCP signaling components has been detected in tooth germs, knowledge of the gene expression patterns of these PCP components during tooth development remains incomplete. The aim of this study is to characterize the temporal and spatial changes in PCP gene expression during tooth development. DESIGN: Expression of Celsr1 and 2, Fzd3 and 6, Vangl1 and 2, and Dvl1-3 genes was analyzed in mouse molar germs from the bud to the bell stage using in situ hybridization...
July 14, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28733464/lineage-tracing-of-epithelial-cells-in-developing-teeth-reveals-two-strategies-for-building-signaling-centers
#20
Wei Du, Jimmy Kuang-Hsien Hu, Wen Du, Ophir D Klein
An important event in organogenesis is the formation of signaling centers, which are clusters of growth factor-secreting cells. In the case of tooth development, sequentially formed signaling centers known as the initiation knot (IK) and the enamel knot (EK) regulate morphogenesis. However, despite the importance of signaling centers, their origin, as well as the fate of the cells composing them, remain open questions. Here, using lineage tracing of distinct epithelial populations, we found that the EK of the mouse incisor is derived de novo from a group of SRY-box 2 (Sox2)-expressing cells in the posterior half of the tooth germ...
September 8, 2017: Journal of Biological Chemistry
keyword
keyword
83976
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"