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https://www.readbyqxmd.com/read/29778935/different-levels-of-pro-and-anti-inflammatory-cytokines-in-patients-with-unipolar-and-bipolar-depression
#1
Ruizhi Mao, Chen Zhang, Jun Chen, Guoqing Zhao, Rubai Zhou, Fan Wang, Jingjing Xu, Tao Yang, Yousong Su, Jia Huang, Zhiguo Wu, Lan Cao, Yong Wang, Yingyan Hu, Chengmei Yuan, Zhenghui Yi, Wu Hong, Zuowei Wang, Daihui Peng, Yiru Fang
BACKGROUND: Immune system dysregulation is critical in the physiopathology of major depressive disorder (MDD) and bipolar disorder (BD). However, it is unclear whether both diseases present the same inflammatory patterns during depressive episodes. We explored the differences in pro- and anti-inflammatory cytokines between unipolar and bipolar depression (BDD) and the trajectory of these cytokines after acute-phase treatment. METHODS: Sixty-four MDD patients, 61 BDD patients, and 62 healthy controls (HCs) were enrolled...
April 25, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29769027/immune-monitoring-after-pediatric-liver-transplantation-the-prospective-chilsfree-cohort-study
#2
Imeke Goldschmidt, André Karch, Rafael Mikolajczyk, Frauke Mutschler, Norman Junge, Eva Doreen Pfister, Tamara Möhring, Lorenzo d'Antiga, Patrick McKiernan, Deirdre Kelly, Dominique Debray, Valérie McLin, Joanna Pawlowska, Loreto Hierro, Kerstin Daemen, Jana Keil, Christine Falk, Ulrich Baumann
BACKGROUND: Although trough levels of immunosuppressive drugs are largely used to monitor immunosuppressive therapy after solid organ transplantation, there is still no established tool that allows for a validated assessment of functional degree of immunosuppression or the identification of clinically relevant over- or under-immunosuppression, depending on graft homeostasis. Reliable non-invasive markers to predict biopsy proven acute rejection (BPAR) do not exist. Literature data suggest that longitudinal measurements of immune markers might be predictive of BPAR, but data in children are scarce...
May 16, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29768601/improving-patient-care-trajectories-an-innovative-quasi-experimental-research-method-for-health-services
#3
Eneida Rached Campos, Djalma de Carvalho Moreira-Filho, Marcos Tadeu Nolasco da Silva
Scores to predict treatment outcomes have earned a well-deserved place in healthcare practice. However, when used to help achieve excellence in the care of a given disease, scores should also take into account organizational and social aspects. This article aims to create scores to obtain key variables and its application in the management of care of a given disease. We present a method called Epidemiological Planning for Patient Care Trajectory (PELC) and its application in a research of HIV pediatric patients...
May 2018: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29768509/aging-related-trajectories-of-lung-function-in-the-general-population-the-doetinchem-cohort-study
#4
Sandra H van Oostrom, Peter M Engelfriet, W M Monique Verschuren, Maarten Schipper, Inge M Wouters, Marike Boezen, Henriëtte A Smit, Huib A M Kerstjens, H Susan J Picavet
The objective of this study was to explore trajectories of lung function decline with age in the general population, and to study the effect of sociodemographic and life style related risk factors, in particular smoking and BMI. For this purpose, we used data from the Doetinchem Cohort Study (DCS) of men and women, selected randomly from the general population and aged 20-59 years at inclusion in 1987-1991, and followed until the present. Participants in the DCS are assessed every five years. Spirometry has been performed as part of this assessment from 1994 onwards...
2018: PloS One
https://www.readbyqxmd.com/read/29767590/time-dependent-efficacy-of-longitudinal-biomarker-for-clinical-endpoint
#5
Ruwanthi Kolamunnage-Dona, Paula R Williamson
Joint modelling of longitudinal biomarker and event-time processes has gained its popularity in recent years as they yield more accurate and precise estimates. Considering this modelling framework, a new methodology for evaluating the time-dependent efficacy of a longitudinal biomarker for clinical endpoint is proposed in this article. In particular, the proposed model assesses how well longitudinally repeated measurements of a biomarker over various time periods (0,t) distinguish between individuals who developed the disease by time t and individuals who remain disease-free beyond time t...
June 2018: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/29765138/does-genomic-sequencing-early-in-the-diagnostic-trajectory-make-a-difference-a-follow-up-study-of-clinical-outcomes-and-cost-effectiveness
#6
Zornitza Stark, Deborah Schofield, Melissa Martyn, Luke Rynehart, Rupendra Shrestha, Khurshid Alam, Sebastian Lunke, Tiong Y Tan, Clara L Gaff, Susan M White
PURPOSE: To systematically investigate the longer-term clinical and health economic impacts of genomic sequencing for rare-disease diagnoses. METHODS: We collected information on continuing diagnostic investigation, changes in management, cascade testing, and parental reproductive outcomes in 80 infants who underwent singleton whole-exome sequencing (WES). RESULTS: The median duration of follow-up following result disclosure was 473 days. Changes in clinical management due to diagnostic WES results led to a cost saving of AU$1,578 per quality-adjusted life year gained, without increased hospital service use...
May 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29763671/searching-for-signals-of-recent-natural-selection-in-genes-of-the-innate-immune-response-ancient-dna-study
#7
Magda Lewandowska, Krystyna Jędrychowska-Dańska, Tomasz Płoszaj, Piotr Witas, Alicja Zamerska, Hanna Mańkowska-Pliszka, Henryk W Witas
The last decade has seen sharp progress in the field of human evolutionary genetics and a great amount of genetic evidence of natural selection has been provided so far. Since host-pathogen co-evolution is difficult to trace due to the polygenic nature of human susceptibility to microbial diseases, of particular interest is any signal of natural selection in response to the strong selective pressure exerted by pathogens. Analysis of ancient DNA allows for the direct insight into changes of a gene pool content over time and enables monitoring allele frequency fluctuations...
May 12, 2018: Infection, Genetics and Evolution
https://www.readbyqxmd.com/read/29762549/frameless-stereotaxis-for-subthalamic-nucleus-deep-brain-stimulation-an-innovative-method-for-the-direct-visualization-of-electrode-implantation-by-intraoperative-x-ray-control
#8
Paolo Mazzone, Alessandro Stefani, Fabio Viselli, Eugenio Scarnati
The recent introduction of frameless devices has enabled stereotactic neurosurgery to reach a level of accuracy that is comparable to traditional frame-based methodologies. Among frameless devices, the Nexframe appears to be very useful in implanting electrodes into the subthalamic nucleus or other structures for deep brain stimulation in Parkinson's disease. However, frameless devices, including the Nexframe, limit the possibility of intraoperative visual control of the placement of electrodes in the brain...
May 15, 2018: Brain Sciences
https://www.readbyqxmd.com/read/29761863/surgical-treatment-of-esophageal-cancer-in-the-era-of-multimodality-management
#9
REVIEW
Alicia S Borggreve, B Feike Kingma, Serg A Domrachev, Mikhail A Koshkin, Jelle P Ruurda, Richard van Hillegersberg, Flavio R Takeda, Lucas Goense
Over the last decades, the treatment of resectable esophageal cancer has evolved into a multidisciplinary process in which all players are essential for treatment to be successful. Medical oncologists and radiation oncologists have been increasingly involved since the implementation of neoadjuvant therapy, which has been shown to improve survival. Although esophagectomy is still considered the cornerstone of curative treatment for locally advanced esophageal cancer, it remains associated with considerable postoperative morbidity, despite promising results of minimally invasive techniques...
May 15, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29761569/cognitive-and-functional-progression-in-alzheimer-disease-a-prediction-model-of-latent-classes
#10
Miriam L Haaksma, Amaia Calderón-Larrañaga, Marcel G M Olde Rikkert, René J F Melis, Jeannie-Marie S Leoutsakos
OBJECTIVE: We sought to replicate a previously published prediction model for progression, developed in the Cache County Dementia Progression Study, using a clinical cohort from the National Alzheimer's Coordinating Center. METHODS: We included 1120 incident Alzheimer disease (AD) cases with at least one assessment after diagnosis, originating from 31 AD centres from the United States. Trajectories of the Mini-Mental State Examination (MMSE) and Clinical Dementia Rating sum of boxes (CDR-sb) were modelled jointly over time using parallel-process growth mixture models in order to identify latent classes of trajectories...
May 15, 2018: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/29760482/glycemic-impact-of-non-nutritive-sweeteners-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
Alexander D Nichol, Maxwell J Holle, Ruopeng An
BACKGROUND/OBJECTIVES: Nonnutritive sweeteners (NNSs) are zero- or low-calorie alternatives to nutritive sweeteners, such as table sugars. A systematic review and meta-analysis of randomized controlled trials was conducted to quantitatively synthesize existing scientific evidence on the glycemic impact of NNSs. SUBJECTS/METHODS: PubMed and Web of Science databases were searched. Two authors screened the titles and abstracts of candidate publications. The third author was consulted to resolve discrepancies...
May 15, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29757832/advance-care-planning-and-anticipatory-decision-making-in-patients-with-alzheimer-disease
#12
Jason T Slyer, Ella Archibald, Fernea Moyo, Marie Truglio-Londrigan
Early advance care planning and anticipatory decision making in the Alzheimer disease (AD) trajectory is a strategy NPs can incorporate to improve managing uncertainty around common decisions. This article explores decisions patients and caregivers face along the AD trajectory and provides resources for patients, caregivers, and NPs.
June 11, 2018: Nurse Practitioner
https://www.readbyqxmd.com/read/29750815/abnormal-gait-pattern-emerges-during-curved-trajectories-in-high-functioning-parkinsonian-patients-walking-in-line-at-normal-speed
#13
Anna Maria Turcato, Marco Godi, Marica Giardini, Ilaria Arcolin, Antonio Nardone, Andrea Giordano, Marco Schieppati
BACKGROUND: Several patients with Parkinson´s disease (PD) can walk normally along straight trajectories, and impairment in their stride length and cadence may not be easily discernible. Do obvious abnormalities occur in these high-functioning patients when more challenging trajectories are travelled, such as circular paths, which normally implicate a graded modulation in the duration of the interlimb gait cycle phases? METHODS: We compared a cohort of well-treated mildly to moderately affected PD patients to a group of age-matched healthy subjects (HS), by deliberately including HS spontaneously walking at the same speed of the patients with PD...
2018: PloS One
https://www.readbyqxmd.com/read/29750375/the-ontario-birth-study-a-prospective-pregnancy-cohort-study-integrating-perinatal-research-into-clinical-care
#14
Laura N Anderson, Julia A Knight, Rayjean J Hung, Sheryl L Hewko, Ryan A Seeto, Mary-Jean Martin, Alison Fleming, Jonathon L Maguire, Stephen G Matthews, Kellie E Murphy, Nan Okun, Jennifer M Jenkins, Stephen J Lye, Alan Bocking
BACKGROUND: Pregnancy and early childhood represent critical periods that impact health throughout the life-course. The Ontario Birth Study (OBS) is a pregnancy cohort study designed as a platform for research on pregnancy complications, maternal and infant health, and the developmental origins of health and disease. METHODS: Pregnant women <17 weeks gestational age were recruited between 2013 and 2015 from antenatal clinics at Mount Sinai Hospital, Toronto, Canada...
May 11, 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29750339/pre-and-postsurgical-cognitive-trajectories-and-quantitative-mri-changes-in-rasmussen-syndrome
#15
Sarah R Rudebeck, Sara Shavel-Jessop, Sophia Varadkar, Tamsin Owen, J Helen Cross, Faraneh Vargha-Khadem, Torsten Baldeweg
OBJECTIVE: To quantify the longitudinal cognitive trajectory, before and after surgery, of Rasmussen syndrome (RS), a rare disease characterized by focal epilepsy and progressive atrophy of one cerebral hemisphere. METHOD: Thirty-two patients (mean age = 6.7 years; 17 male, 16 left hemispheres affected) were identified from hospital records. The changes in intelligence scores during 2 important phases in the patients' journey to treatment were investigated: (1) during the preoperative period (n = 28, mean follow-up 3...
May 11, 2018: Epilepsia
https://www.readbyqxmd.com/read/29749317/exploring-the-associations-between-spiritual-well-being-burden-and-quality-of-life-in-family-caregivers-of-cancer-patients
#16
Roberta Spatuzzi, Maria Velia Giulietti, Marcello Ricciuti, Fabiana Merico, Paolo Fabbietti, Letizia Raucci, Domenico Bilancia, Claudia Cormio, Anna Vespa
OBJECTIVE: The spiritual dimension is important in the process of coping with stress and may be of special relevance for those caring for cancer patients in the various phases of caregivership, although current attention is most prevalent at the end of life. This study explores the associations among spiritual well-being (SWB), caregiver burden, and quality of life (QoL) in family caregivers of patients with cancer during the course of the disease. METHOD: This is a cross-sectional study...
May 11, 2018: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29747342/-the-analysis-of-the-trend-of-mortality-rate-of-falls-in-china-from-1990-to-2015
#17
P P Ye, Y L Er, Y Jin, L L Duan
Objective: To understand the status and trend of the mortality rate of falls in different gender, age groups and provinces in China from 1990 to 2015, to explore the number of subgroups of different trends in all provinces, and to determine the different trajectory of subgroups. Methods: Using the mortality rate of falls in China from 1990 to 2015 from the Global Disease Burden 2015 (data covers 31 provinces, autonomous regions, municipalities, as well as Hong Kong and Macau Special Administrative Regions, excluding Taiwan Province) to describe the status of the mortality rate of falls in different gender, age group and provinces in China 2015 and to calculate the corresponding relative change...
May 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29746917/long-term-trajectories-of-mild-asthma-in-adulthood-and-risk-factors-of-progression
#18
Wenjia Chen, J Mark FitzGerald, Larry D Lynd, Don D Sin, Mohsen Sadatsafavi
BACKGROUND: The majority of asthma patients have mild disease. However, the clinical course of mild asthma and risk factors for progression are not well studied. OBJECTIVE: To examine the long-term trajectories of mild asthma and the effects of early-stage risk factors on the subsequent disease course. METHODS: From the administrative health data of British Columbia, Canada, we identified patients 14 to 45 years of age with newly diagnosed mild asthma between January 1997 and December 2012...
May 7, 2018: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/29745361/a-window-beneath-the-skin-how-computed-tomography-assessment-of-body-composition-can-assist-in-the-identification-of-hidden-wasting-conditions-in-oncology-that-profoundly-impact-outcomes
#19
L E Daly, C M Prado, A M Ryan
Advancements in image-based technologies and body composition research over the past decade has led to increased understanding of the importance of muscle abnormalities, such as low muscle mass (sarcopenia), and more recently low muscle attenuation (MA), as important prognostic indicators of unfavourable outcomes in patients with cancer. Muscle abnormalities can be highly prevalent in patients with cancer (ranging between 10 and 90 %), depending on the cohort under investigation and diagnostic criteria used...
May 2018: Proceedings of the Nutrition Society
https://www.readbyqxmd.com/read/29744956/imaging-resilience-and-recovery-in-alcohol-dependence
#20
REVIEW
Katrin Charlet, Annika Rosenthal, Falk W Lohoff, Andreas Heinz, Anne Beck
BACKGROUND AND AIMS: Resilience and recovery are of increasing importance in the field of alcohol dependence (AD). This paper describes how imaging studies in man can be used to assess the neurobiological correlates of resilience and, if longitudinal, of disease trajectories, progression rates and markers for recovery to inform treatment and prevention options. METHODS: Original articles on recovery and resilience in alcohol addiction and its neurobiological correlates were identified from 'PubMed' and have been analyzed and condensed within a systematic literature review...
May 9, 2018: Addiction
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