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https://www.readbyqxmd.com/read/29331870/postural-instability-differences-between-idiopathic-normal-pressure-hydrocephalus-and-parkinson-s-disease
#1
Yasutaka Nikaido, Toshihiro Akisue, Yoshinaga Kajimoto, Adam Tucker, Yuki Kawami, Hideyuki Urakami, Yuka Iwai, Hisatomo Sato, Tadayuki Nishiguchi, Tetsuya Hinoshita, Kenji Kuroda, Hiroshi Ohno, Ryuichi Saura
OBJECTIVES: We investigated the differences in postural control disability between idiopathic normal pressure hydrocephalus (iNPH) and Parkinson's disease (PD). PATIENTS AND METHODS: Twenty-seven iNPH patients, 20 PD patients, and 20 healthy controls (HCs) were examined using the Timed Up and Go test (TUG) and a force platform for recording the center of pressure (COP) trajectory during quiescent standing and voluntary multidirectional leaning (forward, backward, right, and left for 10 s each)...
January 10, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29329089/neural-circuit-dysfunction-in-mouse-models-of-neurodevelopmental-disorders
#2
REVIEW
Isabel Del Pino, Beatriz Rico, Oscar Marín
Neuropsychiatric disorders arise from the alteration of normal brain developmental trajectories disrupting the function of specific neuronal circuits. Recent advances in human genetics have greatly accelerated the identification of genes whose variation increases the susceptibility for neurodevelopmental disorders, most notably for autism spectrum disorder (ASD) and schizophrenia. In parallel, experimental studies in animal models-most typically in mice-are beginning to shed light on the role of these genes in the development and function of specific brain circuits...
January 9, 2018: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/29324574/sleep-problem-risk-for-adolescents-with-sickle-cell-disease-sociodemographic-physical-and-disease-related-correlates
#3
Cecelia R Valrie, Krystal L Trout, Kayzandra E Bond, Rebecca J Ladd, Nichelle L Huber, Kristen J Alston, Alicia M Sufrinko, Erik Everhart, Beng R Fuh
The aims of the current study were to investigate whether SCD incurs an additional risk for poor sleep over and above the influence of sociodemographic factors (ie, race and sex) during adolescence, and to explore the relationships between sociodemographic, physical (ie, age and pubertal status), and disease-related factors (ie, SCD genotype and hydroxyurea use) on sleep problem risk during adolescence. Black adolescents (age, 12 to 17 y) with SCD (n=53) were recruited from regional pediatric SCD clinics in the southeast and a sample of healthy black adolescents (n=160) were recruited from middle and high schools...
January 10, 2018: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29321226/the-association-of-neurologists-with-headache-health-care-utilization-and-costs
#4
Brian C Callaghan, James F Burke, Kevin A Kerber, Lesli E Skolarus, John P Ney, Brandon Magliocco, Gregory J Esper
OBJECTIVE: To determine the association of a neurologist visit with headache health care utilization and costs. METHODS: Utilizing a large privately insured health care claims database, we identified patients with an incident headache diagnosis (ICD-9 codes 339.xx, 784.0x, 306.81) with at least 5 years follow-up. Patients with a subsequent neurologist visit were matched to controls without a neurologist visit using propensity score matching, accounting for 54 potential confounders and regional variation in neurologist density...
January 10, 2018: Neurology
https://www.readbyqxmd.com/read/29320500/brain-structural-changes-in-cynomolgus-monkeys-administered-with-1-methyl-4-phenyl-1-2-3-6-tetrahydropyridine-a-longitudinal-voxel-based-morphometry-and-diffusion-tensor-imaging-study
#5
Hyeonseok S Jeong, Sang-Rae Lee, Jieun E Kim, In Kyoon Lyoo, Sujung Yoon, Eun Namgung, Kyu-Tae Chang, Bom Sahn Kim, Sejung Yang, Jooyeon J Im, Saerom Jeon, Ilhyang Kang, Jiyoung Ma, Yong-An Chung, Soo Mee Lim
In animal models of Parkinson's disease (PD), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is one of the most widely used agents that damages the nigrostriatal dopaminergic pathway. However, brain structural changes in response to MPTP remain unclear. This study aimed to investigate in vivo longitudinal changes in gray matter (GM) volume and white matter (WM) microstructure in primate models administered with MPTP. In six cynomolgus monkeys, high-resolution magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) scans were acquired 7 times over 32 weeks, and assessments of motor symptoms were conducted over 15 months, before and after the MPTP injection...
2018: PloS One
https://www.readbyqxmd.com/read/29318343/short-term-progression-of-cardiometabolic-risk-factors-in-relation-to-age-at-type-2-diabetes-diagnosis-a-longitudinal-observational-study-of-100-606-individuals-from-the-swedish-national-diabetes-register
#6
Andri O Steinarsson, Araz Rawshani, Soffia Gudbjörnsdottir, Stefan Franzén, Ann-Marie Svensson, Naveed Sattar
AIMS/HYPOTHESIS: The reasons underlying a greater association of premature mortality with early-onset type 2 diabetes relative to late-onset disease are unclear. We evaluated the clinical characteristics at type 2 diabetes diagnosis and the broad trajectories in cardiometabolic risk factors over the initial years following diagnosis in relation to age at diagnosis. METHODS: Our cohort consisted of 100,606 individuals with newly diagnosed type 2 diabetes enrolled in the Swedish National Diabetes Register from 2002 to 2012...
January 9, 2018: Diabetologia
https://www.readbyqxmd.com/read/29313129/characteristics-and-care-pathways-of-advanced-cancer-patients-in-a-palliative-supportive-care-unit-and-an-oncological-ward
#7
Sebastiano Mercadante, Paolo Marchetti, Claudio Adile, Amanda Caruselli, Patrizia Ferrera, Andrea Costanzi, Alessandra Casuccio
BACKGROUND: A supportive palliative care unit (SPCU) may have a positive impact on patients' care. The aim of this study was to compare the pattern of patients admitted to a specialized SPCU and to a traditional oncologic ward (OW) in a consecutive sample of advanced cancer patients. METHODS: Data on patients demographics, reasons for and kind of admission, care-giver, anticancer treatments, being on/off treatment or uncertain, origin setting, who proposed hospital admission, the use of opioids, and hospitalization were gathered...
January 8, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29311096/early-detection-and-evolution-of-pre-leukemic-clones-in-therapy-related-myeloid-neoplasms-following-autologous-sct
#8
Gerbrig Berger, Leonie I Kroeze, Theresia N Koorenhof-Scheele, Aniek O de Graaf, Kenichi Yoshida, Hiroo Ueno, Yuichi Shiraishi, Satoru Miyano, Eva van den Berg, Hein Schepers, Bert A van der Reijden, Seishi Ogawa, Edo Vellenga, Joop H Jansen
Therapy-related myeloid neoplasms (tMNs) are severe adverse events that can occur following treatment with autologous hematopoietic stem cell transplantation (ASCT). This study aimed to investigate the development of tMN following ASCT at the molecular level by whole exome sequencing (WES) and targeted deep sequencing (TDS) in sequential (pre-) tMN samples. WES identified a significantly higher number of mutations in tMN as compared to de novo MDS (median 27 vs 12, p=0.001). The mutations found in tMN did not carry a clear ageing-signature, unlike the mutations found in de novo MDS, indicating a different mutational mechanism...
January 8, 2018: Blood
https://www.readbyqxmd.com/read/29310752/transition-to-adult-care-for-aboriginal-children-with-rheumatic-fever-a-review-informed-by-a-focussed-ethnography-in-northern-australia
#9
Alice G Mitchell, Suzanne Belton, Vanessa Johnston, Anna P Ralph
Aboriginal children in northern Australia have high rates of rheumatic fever and rheumatic heart disease, which are chronic conditions because of the need for long-term treatment and monitoring. This article critically reviews the literature on transition to adult care for children with chronic conditions and considers applicability to the care of these children. The review was merged with findings from a focussed ethnography conducted in four remote Aboriginal communities with young people who have these conditions...
January 9, 2018: Australian Journal of Primary Health
https://www.readbyqxmd.com/read/29310523/docking-molecular-dynamics-binding-energy-mm-pbsa-studies-of-naphthofuran-derivatives-to-identify-potential-dual-inhibitors-against-bace-1-and-gsk-3%C3%AE
#10
Akhil Kumar, Gaurava Srivastava, Arvind S Negi, Ashok Sharma
BACE-1 and GSK-3β both are potential therapeutic drug targets for Alzheimer's disease. Recently, both these targets received attention for designing dual inhibitors. Till now only two scaffolds (triazinone and curcumin) derivatives have been reported as BACE-1 and GSK-3β dual inhibitors. In our previous work, we have reported first in class dual inhibitor for BACE-1 and GSK-3β. In this study we have explored other naphthofuran derivatives for their potential to inhibit BACE-1 and GSK-3β through docking, molecular dynamics, binding energy (MM-PBSA)...
January 8, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29306517/patterns-of-kidney-function-decline-in-autosomal-dominant-polycystic-kidney-disease-a-post-hoc-analysis-from-the-halt-pkd-trials
#11
Godela M Brosnahan, Kaleab Z Abebe, Charity G Moore, Frederic F Rahbari-Oskoui, Kyongtae T Bae, Jared J Grantham, Robert W Schrier, William E Braun, Arlene B Chapman, Michael F Flessner, Peter C Harris, Marie C Hogan, Ronald D Perrone, Dana C Miskulin, Theodore I Steinman, Vicente E Torres
BACKGROUND: Previous clinical studies of autosomal dominant polycystic kidney disease (ADPKD) reported that loss of kidney function usually follows a steep and relentless course. A detailed examination of individual patterns of decline in estimated glomerular filtration rate (eGFR) has not been performed. STUDY DESIGN: Longitudinal post hoc analysis of data collected during the Halt Progression of Polycystic Kidney Disease (HALT-PKD) trials. SETTING & PARTICIPANTS: 494 HALT-PKD Study A participants (younger; preserved eGFR) and 435 Study B participants (older; reduced eGFR) who had more than 3 years of follow-up and 7 or more eGFR assessments...
January 3, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/29306476/the-cha2ds2-vasc-score-strongly-correlates-with-glomerular-filtration-rate-and-predicts-renal-function-decline-over-time-in-elderly-patients-with-atrial-fibrillation-and-chronic-kidney-disease
#12
Jan Beyer-Westendorf, Reinhold Kreutz, Florian Posch, Cihan Ay
BACKGROUND: The decline of renal function affects stroke risk in patients with atrial fibrillation (AF). Here, we aim to study the predictive value of the CHA2DS2-VASc score, a stroke-risk stratification model in AF, for renal function and renal decline in patients with AF and chronic kidney disease (CKD). METHODS: Two electronic health record cohorts with AF and CKD stage III/IV were evaluated (Cohort #1 (IMS-DA, Germany): 18,539 patients with 125,149 estimated glomerular filtration rate (eGFR) measurements; Cohort #2 (IMS-THIN, United Kingdom): 18,240 patients with 133,676 eGFR measurements)...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29302593/anticipating-the-role-of-the-intensive-care-unit-in-healthcare-and-life-trajectories
#13
REVIEW
Grégoire Moutel
Many people think that the intensive care unit is reserved for patients with extreme and life-threatening disease, and as such, it remains hypothetical in the collective conscience, and not something that can be predicted or anticipated. Yet, intensive care can be required in a number of situations, and raises many questions depending on whether the illness is chronic, or of sudden onset. It is essential, in this context, to ask whether, and how potential patients are informed, and prepared for the eventuality of intensive care unit (ICU) care...
December 2017: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29302051/genetic-mapping-of-molar-size-relations-identifies-inhibitory-locus-for-third-molars-in-mice
#14
Nicolas Navarro, A Murat Maga
Molar size in Mammals shows considerable disparity and exhibits variation similar to that predicted by the Inhibitory Cascade model. The importance of such developmental systems in favoring evolutionary trajectories is also underlined by the fact that this model can predict macroevolutionary patterns. Using backcross mice, we mapped QTL for molar sizes controlling for their sequential development. Genetic controls for upper and lower molars appear somewhat similar, and regions containing genes implied in dental defects drive this variation...
January 5, 2018: Heredity
https://www.readbyqxmd.com/read/29298716/persistently-high-psychological-well-being-predicts-better-hdl-cholesterol-and-triglyceride-levels-findings-from-the-midlife-in-the-u-s-midus-longitudinal-study
#15
Barry T Radler, Attilio Rigotti, Carol D Ryff
BACKGROUND: Psychological correlates of blood lipid levels have been previously evaluated mostly in cross sectional studies. However, prospectively measured psychological factors might also predict favorable blood lipid profiles, thereby indicating a healthy mind/body interplay that is associated with less disease, better health and longer lives. METHODS: This paper examined whether longitudinal profiles of psychological well-being over 9-10 years are predictors of blood lipid profiles...
January 3, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29298214/heart-rate-variability-and-its-relation-to-chronic-kidney-disease-results-from-the-prevend-study
#16
Christian H L Thio, Arie M van Roon, Joop D Lefrandt, Ron T Gansevoort, Harold Snieder
OBJECTIVE: In the general population, reduced heart rate variability (HRV) has been associated with cardiovascular disease. However, its relation to chronic kidney disease (CKD) is debated. We therefore investigated the relation between low HRV and renal outcomes. METHODS: In the population-based PREVEND Study, renal outcomes (CKD, eGFR, urinary albumin) were measured at baseline and three consecutive examinations. HRV measures (among which SDNN, standard deviation of normal-to-normal RR-intervals) were calculated from time-series of beat-to-beat pulse-wave recordings at baseline...
January 2, 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29295810/physical-activity-assessment-using-an-activity-tracker-in-patients-with-rheumatoid-arthritis-and-axial-spondyloarthritis-prospective-observational-study
#17
Charlotte Jacquemin, Hervé Servy, Anna Molto, Jérémie Sellam, Violaine Foltz, Frédérique Gandjbakhch, Christophe Hudry, Stéphane Mitrovic, Bruno Fautrel, Laure Gossec
BACKGROUND: Physical activity can be tracked using mobile devices and is recommended in rheumatoid arthritis (RA) and axial spondyloarthritis (axSpA) management. The World Health Organization (WHO) recommends at least 150 min per week of moderate to vigorous physical activity (MVPA). OBJECTIVE: The objectives of this study were to assess and compare physical activity and its patterns in patients with RA and axSpA using an activity tracker and to assess the feasibility of mobile devices in this population...
January 2, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29290274/predictors-of-psychological-distress-trajectories-in-the-first-year-after-a-breast-cancer-diagnosis
#18
Jin-Hee Park, Mison Chun, Yong-Sik Jung, Sun Hyoung Bae
PURPOSE: Psychological distress is a significant and ongoing problem for breast cancer. These mental health problems are often neglected as they are not always properly understood. This study was performed to explore the trajectory of psychological distress over 1 year since breast cancer surgery and to identify the associated factors for the trajectory. METHODS: One hundred seventeen women who underwent surgery for breast cancer completed the psychological distress thermometer and problem lists from after surgery to 12 months after surgery...
December 2017: Asian Nursing Research
https://www.readbyqxmd.com/read/29289656/accurate-prognostic-awareness-facilitates-whereas-better-quality-of-life-and-more-anxiety-symptoms-hinder-end-of-life-care-discussions-a-longitudinal-survey-study-in-terminally-ill-cancer-patients-last-six-months-of-life
#19
Siew Tzuh Tang, Chen Hsiu Chen, Fur-Hsing Wen, Jen-Shi Chen, Wen-Cheng Chang, Chia-Hsun Hsieh, Wen-Chi Chou, Ming-Mo Hou
BACKGROUND: Terminally ill cancer patients do not engage in end-of-life (EOL)-care discussions or do so only when death is imminent, despite guidelines for EOL-care discussions early in their disease trajectory. Most studies on patient-reported EOL-care discussions are cross-sectional without exploring the evolution of EOL-care discussions as death approaches. Cross-sectional studies cannot determine the direction of association between EOL-care discussions and patients' prognostic awareness, psychological well-being, and quality of life (QOL)...
December 28, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29288562/interactions-between-host-sex-and-age-of-exposure-modify-the-virulence-transmission-trade-off
#20
Stephen A Y Gipson, Matthew D Hall
The patterns of immunity conferred by host sex or age represent two sources of host heterogeneity that can potentially shape the evolutionary trajectory of disease. With each host sex or age encountered, a pathogen's optimal exploitative strategy may change, leading to considerable variation in expression of pathogen transmission and virulence. To date, these host characteristics have been studied in the context of host fitness alone, overlooking the effects of host sex and age on the fundamental virulence-transmission trade-off faced by pathogens...
December 29, 2017: Journal of Evolutionary Biology
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