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OSA oxidative stress

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https://www.readbyqxmd.com/read/28065687/restless-legs-syndrome-and-cardiovascular-disease-a-research-roadmap
#1
REVIEW
Daniel J Gottlieb, Virend K Somers, Naresh M Punjabi, John W Winkelman
In this paper, we first critically appraise the epidemiologic literature examining the association of restless legs syndrome (RLS) with cardiovascular disease (CVD) and then consider whether lessons learned from the study of cardiovascular consequences of other sleep disorders might inform a research agenda to examine the potential mechanisms of cardiovascular morbidity of RLS. Cross-sectional and longitudinal studies are both mixed as to whether there is a meaningful association of RLS and CVD. On the other hand, numerous cross-sectional and longitudinal observational studies have shown a strong association of obstructive sleep apnea (OSA) with CVD risk...
October 27, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/28040290/obstructive-sleep-and-atrial-fibrillation-pathophysiological-mechanisms-and-therapeutic-implications
#2
REVIEW
Christos A Goudis, Dimitrios G Ketikoglou
Atrial fibrillation (AF) is the commonest arrhythmia in clinical practice and is associated with increased cardiovascular morbidity and mortality. Obstructive sleep apnea (OSA), a common breathing disorder, is an independent risk factor for AF. Several pathophysiological mechanisms, including apnea-induced hypoxia, intrathoracic pressure shifts, sympathovagal imbalance, atrial remodeling, oxidative stress, inflammation and neurohumoral activation have been implicated in the occurrence of AF in OSA patients...
December 22, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28000217/thiol-disulfide-homeostasis-as-a-novel-indicator-of-oxidative-stress-in-obstructive-sleep-apnea-patients
#3
Mehmet Emre Dinc, Cengiz Ozdemir, Nilhan Nurlu Ayan, Nazım Bozan, Seckin Ulusoy, Cemile Koca, Ozcan Erel
OBJECTIVES: The aim of the present study was to assess thiol/disulfide (SS) homeostasis as a novel indicator of oxidative stress in patients with obstructive sleep apnea (OSA) and to investigate the effect of continuous positive airway pressure (CPAP) therapy on oxidative parameters. STUDY DESIGN: Prospective clinical study. METHODS: A total of 104 subjects, 44 in an OSA group and 60 in two control groups (control simple snoring group, control OSA group) were included...
December 21, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27921430/-obstructive-sleep-apnoea-and-type-2-diabetes-mellitus
#4
Andrea Plíhalová, Kateřina Westlake, Jan Polák
Obstructive sleep apnoea syndrome (OSA) is a disease very frequently occurring in people with type 2 diabetes, that significantly increases cardiovascular morbidity and mortality. In a number of studies, OSA has been identified as an independent risk factor for the development of insulin resistance, glucose intolerance and type 2 diabetes mellitus. Disorders of glucose homeostasis in patients with OSA are probably mediated by chronic intermittent hypoxia and/or sleep fragmentation through activation of the sympathetic nervous system, the hypothalamic-pituitary-adrenal stress axis, pro-inflammatory paths or oxidative stress...
2016: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/27896929/impact-of-inflammation-and-oxidative-stress-on-carotid-intima-media-thickness-in-obstructive-sleep-apnea-patients-without-metabolic-syndrome
#5
Ya-Ting Chang, Hsin-Ching Lin, Wen-Neng Chang, Nai-Wen Tsai, Chih-Cheng Huang, Hung-Chen Wang, Chia-Te Kung, Yu-Jih Su, Wei-Che Lin, Ben-Chung Cheng, Chih-Min Su, Ting-Yao Chen, Yi-Fang Chiang, Cheng-Hsien Lu
Obstructive sleep apnea (OSA) increases the risk of cardiovascular diseases, and carotid intima-media thickness (IMT) is a good indicator of the severity of atherosclerotic disease. This study tested the hypothesis that inflammation and oxidative stress determined carotid IMT in patients with OSA. The carotid IMT, mean systolic and diastolic pressure (night and morning) were significantly higher and the level of thiols and high-density lipoprotein were significantly lower in our 121 OSA patients than in 27 controls (P < 0...
November 28, 2016: Journal of Sleep Research
https://www.readbyqxmd.com/read/27876406/adenotonsillectomy-can-decrease-enuresis-and-sympathetic-nervous-activity-in-children-with-obstructive-sleep-apnea-syndrome
#6
Hao Ding, Mengmei Wang, Ke Hu, Jing Kang, Si Tang, Wen Lu, Lifang Xu
BACKGROUND: The nocturnal intermittent hypoxia caused by obstructive sleep apnea syndrome (OSAS) can provoke the sympathetic nervous activity (SNA). Salivary alpha-amylase (sAA) is a sensitive, non-invasive biomarker for reflecting the SNA, and a useful marker for pediatric OSAS subjects. Adenotonsillar hypertrophy (ATH) is the most commonly identified risk factor in OSAS childhood, therefore, several studies showed that the adenotonsillectomy (T&A) may alleviate nocturnal enuresis (NE) in children with OSAS...
November 9, 2016: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27864139/evening-and-morning-peroxiredoxin-2-redox-oligomeric-state-changes-in-obstructive-sleep-apnea-red-blood-cells-correlation-with-polysomnographic-and-metabolic-parameters
#7
Amélia Feliciano, Fátima Vaz, Vukosava M Torres, Cristina Valentim-Coelho, Rita Silva, Vesna Prosinecki, Bruno M Alexandre, Ana S Carvalho, Rune Matthiesen, Atul Malhotra, Paula Pinto, Cristina Bárbara, Deborah Penque
We have examined the effects of Obstructive Sleep Apnea (OSA) on red blood cell (RBC) proteome variation at evening/morning day time to uncover new insights into OSA-induced RBC dysfunction that may lead to OSA manifestations. Dysregulated proteins mainly fall in the group of catalytic enzymes, stress response and redox regulators such as peroxiredoxin 2 (PRDX2). Validation assays confirmed that at morning the monomeric/dimeric forms of PRDX2 were more overoxidized in OSA RBC compared to evening samples. Six month of positive airway pressure (PAP) treatment decreased this overoxidation and generated multimeric overoxidized forms associated with chaperone/transduction signaling activity of PRDX2...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27856716/relationship-between-obstructive-sleep-apnea-and-endogenous-carbon-monoxide
#8
Masanori Azuma, Kimihiko Murase, Ryo Tachikawa, Satoshi Hamada, Takeshi Matsumoto, Takuma Minami, Morito Inouchi, Kiminobu Tanizawa, Tomohiro Handa, Toru Oga, Michiaki Mishima, Kazuo Chin
: Endogenous carbon monoxide (CO) levels are recognized as a surrogate marker for activity of heme oxygenase-1, which is induced by various factors, including hypoxia and oxidative stress. Few reports have evaluated endogenous CO in patients with obstructive sleep apnea (OSA). Whether OSA more greatly affects exhaled or blood CO is not known. Sixty-nine patients with suspected OSA were prospectively included in this study. Exhaled and blood CO were evaluated at night and morning. Blood and exhaled CO levels were well correlated both at night and morning (r = 0...
January 1, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27843225/glaucoma-and-its-association-with-obstructive-sleep-apnea-a-narrative-review
#9
REVIEW
Aditya Chaitanya, Vijaya H Pai, Aswini Kumar Mohapatra, Ramesh S Ve
Obstructive sleep apnea (OSA) is one of the systemic risk factors for glaucoma which causes irreversible visual field (VF) damage. We reviewed the published data of all types of studies on the association between these two conditions and papers regarding functional and structural changes related to glaucomatous damage using Scopus, web of science, and PubMed databases. There is evidence that the prevalence of glaucoma is higher in OSA patients, which independent of intraocular pressure (IOP). Studies have reported thinning of retinal nerve fiber layer (RNFL), alteration of optic nerve head, choroidal and macular thickness, and reduced VF sensitivity in patients of OSA with no history glaucoma...
September 2016: Oman Journal of Ophthalmology
https://www.readbyqxmd.com/read/27800512/chronic-intermittent-hypoxia-and-obstructive-sleep-apnea-an-experimental-and-clinical-approach
#10
REVIEW
Emilia Sforza, Fréderic Roche
Obstructive sleep apnea (OSA) is a prevalent sleep disorder considered as an independent risk factor for cardiovascular consequences, such as systemic arterial hypertension, ischemic heart disease, cardiac arrhythmias, metabolic disorders, and cognitive dysfunction. The pathogenesis of OSA-related consequence is assumed to be chronic intermittent hypoxia (IH) inducing alterations at the molecular level, oxidative stress, persistent systemic inflammation, oxygen sensor activation, and increase of sympathetic activity...
2016: Hypoxia
https://www.readbyqxmd.com/read/27790155/exercise-attenuates-intermittent-hypoxia-induced-cardiac-fibrosis-associated-with-sodium-hydrogen-exchanger-1-in-rats
#11
Tsung-I Chen, Wei-Chia Tu
Purpose: To investigate the role of sodium-hydrogen exchanger-1 (NHE-1) and exercise training on intermittent hypoxia-induced cardiac fibrosis in obstructive sleep apnea (OSA), using an animal model mimicking the intermittent hypoxia of OSA. Methods: Eight-week-old male Sprague-Dawley rats were randomly assigned to control (CON), intermittent hypoxia (IH), exercise (EXE), or IH combined with exercise (IHEXE) groups. These groups were randomly assigned to subgroups receiving either a vehicle or the NHE-1 inhibitor cariporide...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27774119/role-of-oxidative-stress-in-the-neurocognitive-dysfunction-of-obstructive-sleep-apnea-syndrome
#12
REVIEW
Li Zhou, Ping Chen, Yating Peng, Ruoyun Ouyang
Obstructive sleep apnea syndrome (OSAS) is characterized by chronic nocturnal intermittent hypoxia and sleep fragmentations. Neurocognitive dysfunction, a significant and extraordinary complication of OSAS, influences patients' career, family, and social life and reduces quality of life to some extent. Previous researches revealed that repetitive hypoxia and reoxygenation caused mitochondria and endoplasmic reticulum dysfunction, overactivated NADPH oxidase, xanthine oxidase, and uncoupling nitric oxide synthase, induced an imbalance between prooxidants and antioxidants, and then got rise to a series of oxidative stress (OS) responses, such as protein oxidation, lipid peroxidation, and DNA oxidation along with inflammatory reaction...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27699083/oxidative-stress-induced-telomere-length-shortening-of-circulating-leukocyte-in-patients-with-obstructive-sleep-apnea
#13
Kyung Soo Kim, Jin Wook Kwak, Su Jin Lim, Yong Kyun Park, Hoon Shik Yang, Hyun Jik Kim
The main mechanism of pathogenesis which causes systemic complications in obstructive sleep apnea (OSA) patients is believed to be intermittent hypoxia-induced intermediary effect and it depends on the burden of oxidative stress during sleep. We aimed to search the predictive markers which reflect the burden of systemic oxidative stress in patients with OSA and whether excessive telomere length shortening is a characteristic feature that can assess oxidative stress levels. We used quantitative PCR to measure telomere length using peripheral blood genomic DNA...
October 2016: Aging and Disease
https://www.readbyqxmd.com/read/27693594/osa-and-cardiac-arrhythmogenesis-mechanistic-insights
#14
REVIEW
Anna M May, David R Van Wagoner, Reena Mehra
A surge of data has reproducibly identified strong associations of OSA with cardiac arrhythmias. As an extension of epidemiologic and clinic-based findings, experimental investigations have made strides in advancing our understanding of the putative OSA and cardiac arrhythmogenesis mechanistic underpinnings. Although most studies have focused on the links between OSA and atrial fibrillation (AF), relationships with ventricular arrhythmias have also been characterized. Key findings implicate OSA-related autonomic nervous system fluctuations typified by enhanced parasympathetic activation during respiratory events and sympathetic surges subsequent to respiratory events, which contribute to augmented arrhythmic propensity...
January 2017: Chest
https://www.readbyqxmd.com/read/27619033/a-novel-method-for-evaluation-of-oxidative-stress-in-children-with-osa
#15
Fatih Gul, Togay Muderris, Gokhan Yalciner, Halil Ibrahim Mise, Yagmur Canan, Mehmet Ali Babademez, Ozcan Erel
OBJECTIVES: To evaluate the role of adenotonsillar hypertrophy and the outcomes of adenotonsillectomy (AT) on oxidative stress for obstructive sleep apnea (OSA) in children using a new method; thiol/disulfide homeostasis. METHODS: The study is consisted of 45 children with OSA and 38 healthy control subjects with similar age and sex. Children 3-12 years of age with OSA, defined as having an apnea/hypopnea index (AHI) of 5 or more in an overnight polysomnography, underwent adenotonsillectomy...
October 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27617449/vascular-endothelial-dysfunction-caused-by-oxidative-stress-is-a-predictor-factor-for-complications-of-obstructive-sleep-apnea-syndrome
#16
K Kilic, B Aktan, M Sedat-Sakat, A Kızıltunç, O Yoruk
Objective: Obstructive sleep apnea syndrome (OSAS) is characterized by repetitive episodes of upper airway obstruction that occur during sleep which leads to cardiovascular, neurovascular and metabolic diseases. The mechanisms of complications in these patients are unclear. In this report, we aimed to determine the cause of oxidative imbalance in patients with OSAS and to evaluate the vascular endothelial dysfunction as a suspect for complications of the disease. Materials and Methods: Fifty patients diagnosed as moderate or severe OSAS (AHI > 15) by polysomnography and 50 healthy volunteers are included in the study...
February 15, 2016: West Indian Medical Journal
https://www.readbyqxmd.com/read/27600660/serum-levels-of-magnesium-and-their-relationship-with-crp-in-patients-with-osa
#17
H Karamanli, D Kizilirmak, R Akgedik, M Bilgi
BACKGROUND: Low levels of magnesium (Mg) are associated with chronic inflammatory stress. Some animal studies have reported that a moderate deficiency of Mg, similar to that which occurs in humans, may increase inflammatory or oxidative stress stimulated by other factors, such as disrupted sleep or sleep deficiency. PURPOSE: This cross-sectional study evaluated the relationship between serum levels of Mg and the inflammatory response in patients with a new diagnosis of obstructive sleep apnea (OSA)...
September 6, 2016: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/27542875/impact-of-obstructive-sleep-apnea-on-neurocognitive-function-and-impact-of-continuous-positive-air-pressure
#18
REVIEW
Charles R Davies, John J Harrington
There is evidence that obstructive sleep apnea (OSA) can negatively impact attention, memory, learning, executive function, and overall intellectual function in adults and children. Imaging techniques, including MRI, MR diffusion tensor imaging, MR spectroscopy, and fMRI, have provided additional insight into the anatomic and functional underpinnings of OSA-related cognitive impairment. Both animal and human studies have looked to elucidate the separate effects of oxygen desaturation and sleep fragmentation on independent aspects of cognition...
September 2016: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/27542874/consequences-of-obstructive-sleep-apnea-cardiovascular-risk-of-obstructive-sleep-apnea-and-whether-continuous-positive-airway-pressure-reduces-that-risk
#19
REVIEW
Rami Khayat, Adam Pleister
Obstructive sleep apnea (OSA) is present in up to 25% of otherwise healthy individuals. OSA is associated with intermittent hypoxia, oxidative stress, sympathetic activation, and an inflammatory response. These perturbations mediate the role of OSA as an independent and modifiable risk factor for cardiovascular disease (CVD). OSA can induce CVD or accelerate the progression of CVD into an end-stage disorder, including heart failure and stroke. Current clinical recommendations are based on existing clinical trial data and the clinical experience of our program; current and future clinical trials will help to optimize management of OSA in the setting of CVD...
September 2016: Sleep Medicine Clinics
https://www.readbyqxmd.com/read/27524971/a-novel-chip-for-cyclic-stretch-and-intermittent-hypoxia-cell-exposures-mimicking-obstructive-sleep-apnea
#20
Noelia Campillo, Ignasi Jorba, Laura Schaedel, Blai Casals, David Gozal, Ramon Farré, Isaac Almendros, Daniel Navajas
Intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), plays a critical role in the pathogenesis of OSA-associated morbidities, especially in the cardiovascular and respiratory systems. Oxidative stress and inflammation induced by IH are suggested as main contributors of end-organ dysfunction in OSA patients and animal models. Since the molecular mechanisms underlying these in vivo pathological responses remain poorly understood, implementation of experimental in vitro cell-based systems capable of inducing high-frequency IH would be highly desirable...
2016: Frontiers in Physiology
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